Bidirectional deep brain stimulation (DBS) platforms have enabled a surge in hours of recordings in naturalistic environments, allowing further insight into neurological and psychiatric disease states. However, high amplitude, high frequency stimulation generates artifacts that contaminate neural signals and hinder our ability to interpret the data. This is especially true in psychiatric disorders, for which high amplitude stimulation is commonly applied to deep brain structures where the native neural activity is miniscule in comparison. Here, we characterized artifact sources in recordings (...) from a bidirectional DBS platform, the Medtronic Summit RC + S, with the goal of optimizing recording configurations to improve signal to noise ratio (SNR). Data were collected from three subjects in a clinical trial of DBS for obsessive-compulsive disorder. Stimulation was provided bilaterally to the ventral capsule/ventral striatum (VC/VS) using two independent implantable neurostimulators. We first manipulated DBS amplitude within safe limits (2–5.3 mA) to characterize the impact of stimulation artifacts on neural recordings. We found that high amplitude stimulation produces slew overflow, defined as exceeding the rate of change that the analog to digital converter can accurately measure. Overflow led to expanded spectral distortion of the stimulation artifact, with a six fold increase in the bandwidth of the 150.6 Hz stimulation artifact from 147–153 to 140–180 Hz. By increasing sense blank values during high amplitude stimulation, we reduced overflow by as much as 30% and improved artifact distortion, reducing the bandwidth from 140–180 Hz artifact to 147–153 Hz. We also identified artifacts that shifted in frequency through modulation of telemetry parameters. We found that telemetry ratio changes led to predictable shifts in the center-frequencies of the associated artifacts, allowing us to proactively shift the artifacts outside of our frequency range of interest. Overall, the artifact characterization methods and results described here enable increased data interpretability and unconstrained biomarker exploration using data collected from bidirectional DBS devices. (shrink)

Plural predication is a pervasive part of ordinary language. We can say that some people are fifty in number, are surrounding a building, come from many countries, and are classmates. These predicates can be true of some people without being true of any one of them; they are non-distributive predications. However, the apparatus of modern logic does not allow a place for them. Thomas McKay here explores the enrichment of logic with non-distributive plural predication and quantification. His book will (...) be of great interest to philosophers of language, linguists, metaphysicians, and logicians. (shrink)

Does the formation of delusions involve abnormal reasoning? According to the prominent ‘two-factor’ theory of delusions (e.g. Coltheart, 2007), the answer is yes. The second factor in this theory is supposed to affect a deluded individual's ability to evaluate candidates for belief. However, most published accounts of the two-factor theory have not said much about the nature of this second factor. In an effort to remedy this shortcoming, Coltheart, Menzies and Sutton (2010) recently put forward a Bayesian account of inference (...) in delusions. I outline some criticisms of this important account, and sketch an alternative account of delusional inference that, I argue, avoids these criticisms. Specifically, I argue that the second factor in delusion formation involves a systematic deviation from Bayesian updating, a deviation that may be characterized as a bias towards ‘explanatory adequacy’. I present a numerical model of this idea and show that my alternative account is broadly consistent with prominent prediction error models of delusion formation (e.g. Corlett, Murray et al., 2007). (shrink)

I argue that, all else being equal, theism is more probable than naturalism on the assumption that human beings are able to arrive at a body of moral knowledge that is largely accurate and complete. I put forth this thesis on grounds that, if naturalism is true, the explanation of the content of our moral intuitions terminates either in biological-evolutionary processes or in social conventions adopted for pragmatic reasons; that, if this is so, our moral intuitions were selected for their (...) utility, not their truth; and that, if our moral intuitions were so selected, they are probably false. I defend the argument against three objections: first, that the argument amounts to a generic skeptical challenge; second, that ethical naturalism explains how our moral intuitions could have been selected for their truth; and third, that there is a pre-established harmony between the utility of moral beliefs and their truth-values. (shrink)

Young and colleagues . Betwixt life and death: case studies of the Cotard delusion. In P. W. Halligan & J. C. Marshall , Method in madness: Case studies in cognitive neuropsychiatry. Mahway, NJ: Lawrence Erlbaum Associates.) have suggested that cases of the Cotard delusion result when a particular perceptual anomaly occurs in the context of an internalising attributional style. This hypothesis has not previously been tested directly. We report here an investigation of attributional style in a 24-year-old woman with Cotard (...) delusion . LU’s attributional style was assessed using the Internal, Personal and Situational Attributions Questionnaire . A new measure of causal locus: the internal, personal and situational attributions questionnaire. Personality and Individual Differences, 20, 261–264.). LU showed a significantly greater proportion of internalising attributions than the control group, both overall and for negative events specifically. The results obtained thus support an association of Cotard delusion with an internalising attributional style, and are therefore consistent with the account of Young and colleagues. The potential brain basis of Cotard delusion is discussed. (shrink)

We review scholarship that examines relationships - and distinctions - between religion and delusion. We begin by outlining and endorsing the position that both involve belief. Next, we present the prevailing psychiatric view that religious beliefs are not delusional if they are culturally accepted. While this cultural exemption has controversial implications, we argue it is clinically valuable and consistent with a growing awareness of the social - as opposed to purely epistemic - function of belief formation. Finally, we review research (...) on continuities between religious and delusional cognition, which reveals that religious content is quite common in delusions and which provides tentative evidence for a positive relationship between religious belief and delusion-like belief in the general population. (shrink)

Anyone who admits the existence of composite objects allows a certain kind of coincidence, coincidence of a thing with its parts. I argue here that a similar sort of coincidence, coincidence of a thing with the stuff that constitutes it, should be equally acceptable. Acknowledgement of this is enough to solve the traditional problem of the coincidence of a statue and the clay or bronze it is made of. In support of this, I offer some principles for the persistence of (...) stuff that are general, not relying on the particular features of a kind of stuff in the way that principles for the persistence for a thing would. This provides a non-arbitrary grounding for stuff that is independent of the conditions on the nature and persistence of things the stuff composes. The principles also provide a general basis for responding to other questions about coincident stuff. (shrink)

The impact of our desires and preferences upon our ordinary, everyday beliefs is well-documented [Gilovich, T. . How we know what isn’t so: The fallibility of human reason in everyday life. New York: The Free Press.]. The influence of such motivational factors on delusions, which are instances of pathological misbelief, has tended however to be neglected by certain prevailing models of delusion formation and maintenance. This paper explores a distinction between two general classes of theoretical explanation for delusions; the motivational (...) and the deficit. Motivational approaches view delusions as extreme instances of self-deception; as defensive attempts to relieve pain and distress. Deficit approaches, in contrast, view delusions as the consequence of defects in the normal functioning of belief mechanisms, underpinned by neuroanatomical or neurophysiological abnormalities. It is argued that although there are good reasons to be sceptical of motivational theories , recent experiments confirm that motives are important causal forces where delusions are concerned. It is therefore concluded that the most comprehensive account of delusions will involve a theoretical unification of both motivational and deficit approaches. (shrink)

I address an objection to inference to the best explanation due to Bas C. van Fraassen, according to which explanatory virtues cannot confirm a theory, since they make the theory more informative and thus less likely to be true given the probability axioms. I try to show that van Fraassen’s argument, once made precise, is deductively invalid, and that even an ampliative version of the argument (i) implies, absurdly, that no theory is confirmed by its fit with empirical data; (ii) (...) fails to account for confirmatory closure under deduction; and (iii) falsely presupposes that a theory and its sub-theories can be competing explanations. (shrink)

From an evolutionary standpoint, a default presumption is that true beliefs are adaptive and misbeliefs maladaptive. But if humans are biologically engineered to appraise the world accurately and to form true beliefs, how are we to explain the routine exceptions to this rule? How can we account for mistaken beliefs, bizarre delusions, and instances of self-deception? We explore this question in some detail. We begin by articulating a distinction between two general types of misbelief: those resulting from a breakdown in (...) the normal functioning of the belief formation system (e.g., delusions) and those arising in the normal course of that system's operations (e.g., beliefs based on incomplete or inaccurate information). The former are instances of biological dysfunction or pathology, reflecting “culpable” limitations of evolutionary design. Although the latter category includes undesirable (but tolerable) by-products of “forgivably” limited design, our quarry is a contentious subclass of this category: misbeliefs best conceived as design features. Such misbeliefs, unlike occasional lucky falsehoods, would have been systematically adaptive in the evolutionary past. Such misbeliefs, furthermore, would not be reducible to judicious – but doxastically1noncommittal – action policies. Finally, such misbeliefs would have been adaptive in themselves, constituting more than mere by-products of adaptively biased misbelief-producing systems. We explore a range of potential candidates for evolved misbelief, and conclude that, of those surveyed, onlypositive illusionsmeet our criteria. (shrink)

Satisficing consequentialism is often used as a way of solving the demandingness objection, but many forms of satisficing consequentialism fail to do so. Further, those that do are vulnerable to the objections Ben Bradley outlined in Against Satisficing Consequentialism. In this paper, I present a new type of satisficing consequentialism which resolves the demandingness objection, is in-line with common intuitions about moral responsibility, and avoids Bradley's criticisms.

In the light of increasing public mistrust, there is an urgent need to clarify the moral status of the medical profession and of the relationship of the clinician to his/her patients. In addressing this question, I first establish the coherence, within moral philosophy generally, of the concept of supererogation . I adopt the notion of an act of “unqualified” supererogation as one that is non-derivatively good, praiseworthy, and freely undertaken for others' benefit at the risk of some cost to the (...) agent. I then argue that committing oneself to the profession of clinical medicine is an act of this kind. This is the case, not because the aim of medicine is to help patients, but because of the open ended commitment of time and the vulnerability to the consequences of failure that the clinician must accept. (shrink)

Cochlear implants electrically stimulate surviving auditory neurons in the cochlea to provide severely or profoundly deaf people with access to hearing. Signal processing strategies derive frequency-specific information from the acoustic signal and code amplitude changes in frequency bands onto amplitude changes of current pulses emitted by the tonotopically arranged intracochlear electrodes. This article first describes how parameters of the electrical stimulation influence the loudness evoked and then summarizes two different phenomenological models developed by McKay and colleagues that have been (...) used to explain psychophysical effects of stimulus parameters on loudness, detection, and modulation detection. The Temporal Model is applied to single-electrode stimuli and integrates cochlear neural excitation using a central temporal integration window analogous to that used in models of normal hearing. Perceptual decisions are made using decision criteria applied to the output of the integrator. By fitting the model parameters to a variety of psychophysical data, inferences can be made about how electrical stimulus parameters influence neural excitation in the cochlea. The Detailed Model is applied to multi-electrode stimuli, and includes effects of electrode interaction at a cochlear level and a transform between integrated excitation and specific loudness. The Practical Method of loudness estimation is a simplification of the Detailed Model and can be used to estimate the relative loudness of any multi-electrode pulsatile stimuli without the need to model excitation at the cochlear level. Clinical applications of these models to novel sound processing strategies are described. (shrink)

Reflecting on a moment when a vegan meal was presented to him as “lesbian food,” McKay’s essay critiques the concept of “species,” drawing on Judith Butler’s deconstruction of the sex/gender opposition. Social life, he argues, is shaped by “compulsory humanity,” a disposition in which species functions as a regulatory ideal rather than a biological essence. McKay works this critical stance into a positive description of being vegan by turning to Wittgenstein’s concept of the “form of life,” and the (...) way his thought has been developed in relation to animal ethics. McKay’s claim is that thinking of veganism as a form of life allows for making sense of the profound form of identification with others that it expresses, evading and challenging the very notion of being human. (shrink)

Nos societes ont evolue au cours du XXe siecle selon un mode de developpement qui n'est tout simplement pas viable a long terme et qui provoquera de graves crises environnementales. Nous faisons presentement face au defi crucial de la survie de l'humanite, nous en sommes de plus en plus conscients. Aussi, mon propos ne consistera pas a enumerer toutes les catastrophes ecologiques qui nous menacent si nous persistons dans la voie du developpement non durable. Je veux plutot soulever une serie (...) de reflexions et suggerer quelques principes qui peuvent guider nos efforts pour amorcer les necessaires changements. J'expose donc dans cet ouvrage les elements de politique que j'estime souhaitables et realisables pour prendre le virage vers ce que j'appelle le Quebec vert et bleu. Scott McKay. (shrink)

To meet the luck objection to incompatibilism, philosophers such as Timothy O’Connor, Randolph Clark, and William Rowe resurrected the Reidian notion of agent causation, which implies the “Substance-Causal Thesis” (SCT): some causes are fundamentally substances, not events. I examine an objection to SCT by C. D. Broad, developed by Carl Ginet, that substances cannot cause events because substances cannot explain why events happen when they do. The objection fails as it rests on a demand for contrastive explanations of free actions. (...) However, I show that a slightly different objection succeeds in showing SCT false. (shrink)

Von Hippel & Trivers (VH&T) propose that self-deception has evolved to facilitate the deception of others. However, they ignore the subjective moral costs of deception and the crucial issue of credibility in self-deceptive speech. A self-signaling interpretation can account for the ritualistic quality of some self-deceptive affirmations and for the often-noted gap between what self-deceivers say and what they truly believe.

I outline and defend a version of the aesthetic argument for the existence of God, according to which theism explains our capacity for subjective aesthetic experience better than its major competitor, naturalism. I argue that naturalism fails to adequately explain the nature and range of our aesthetic experiences, since these are amenable neither to standard Darwinian explanation nor to explanation in terms of more complex sociobiological mechanisms such as sexual selection or between-group selection. I concede that aesthetic experience may be (...) an evolutionary spandrel but argue that the conjunction of this thesis with naturalism is highly improbable given the prevalence of beauty in the natural world. Theism, on the other hand, furnishes a robust personal explanation of aesthetic experience, since on theism God has both good reasons to bring such experiences about and the power to do so. I address an objection to the theistic explanation from broadly negative aesthetic experiences, arguing that God plausibly has many reasons to allow these. I contend that this formulation of the argument is superior to other extant versions, since it does not depend on controversial probability judgments, dubious analogies between natural phenomena and human artefacts, or objectivism about aesthetic values. (shrink)

In this essay, I defend a mind-body dualism, according to which human minds are immaterial substances that exercise non-redundant causal powers over bodies, against the notorious problem of psychophysical causation. I explicate and reply to three formulations of the problem: (i) the claim that, on dualism, psychophysical causation is inconsistent with physical causal closure, (ii) the claim that psychophysical causation on the dualist view is intolerably mysterious, and (iii) Jaegwon Kim’s claim that dualism fails to account for causal pairings. Ultimately, (...) I conclude that these objections fail and that dualist interactionism is no more problematic or mysterious than physical causation. (shrink)

After a decade of intense debate about mechanisms, there is still no consensus characterization. In this paper we argue for a characterization that applies widely to mechanisms across the sciences. We examine and defend our disagreements with the major current contenders for characterizations of mechanisms. Ultimately, we indicate that the major contenders can all sign up to our characterization.

I reply to an influential objection to evolutionary debunking arguments against moral realism. According to this objection, our capacity for autonomous rational reflection allows us to grasp moral truths independently of distorting evolutionary influences, so those influences do not prevent us from having moral knowledge. I argue that rational moral reflection is not, in fact, autonomous from evolutionary influences, since it depends on our evolved, pre-reflective grasp of moral properties. I then consider and reject the suggestion that realists can supply (...) an autonomous foundation for rational moral reflection or do without any such foundation. Next, I address the allegation that my arguments have skeptical implications for rational reflection in non-moral domains. Finally, I conclude with a gesture toward a more promising route for realists who oppose debunking arguments. (shrink)

This paper critiques the standard presentation of arguments from analogy in logic textbooks and offers an alternative way of understanding them which renders them both more plausible and more easily evaluated for their strength. The typical presentation presents analogies as inductive arguments in which a set of properties, known to be shared by two logical domains, supports an inference about a further property, known to belong to one domain and inferred to belong to the target domain. But framed in these (...) terms, the strength of the argument depends entirely on the relevance of the known shared properties to the inferred shared property, meaning the argument rests on an unstated assumption. Against this view, the author maintains that arguments from analogy are figurative ways of addressing properties of the target logical domain. By comparing or contrasting two logical domains, analogies articulate a general principle which illustrates something difficult to imagine or to describe literally about the target domain. Analogies can be reformulated and evaluated as deductive arguments on this view, with their chief logical import being the inquiry they incite in students as to whether the general principle is true and sufficiently general to apply to the target domain. (shrink)

I want to present some evidence that facts about de re attitudes or causal facts are important in the explanation of actions. In particular, I will argue that an attempt by Ernest Sosa and Mark Pastin [4] to give a scheme for explaining intentional actions fails. By adding either de re or causal locutions we can devise a more adequate schema for explaining action, but their analysis had been designed to eliminate de re locutions from explanations of intentional action. Showing (...) the failure of their analysis does not, of course, show that de re or causal elements are required in these explanations, since it does not rule out the possibility of alternative explanatory schemes. But the centrality of de re or causal elements is supported by the inadequacy of their attempts to dispense with them. (shrink)

This paper mentions several different sorts of "essentialism," and examines various senses in which quantified modal logic is "committed to" the most troublesome kind of essentialism. It is argued that essentialism is neither provable, Nor entailed by any contingently true non-Modal sentence. But quantified modal logic is committed to the meaningfulness of essentialism. This sort of commitment may be made innocuous by requiring that essentialism simply be made logically false; some of the consequences of taking this line are explored.

In studying logic, one learns how to establish that a conclusion follows from a set of premises. Those arguments that exhibit one of the valid forms of the deductive system under study are valid. There may be questions about what forms are exhibited by various arguments - Is this English conditional really truth-functional? Is this disjunction really inclusive? Are the English predicates used with uniform meaning? - but none of these problems undermine the claim that if an argument exhibits a (...) valid form of a system for deductive logic, then that argument is valid.When we move on to study invalidity, however, we find that the situation is not parallel. Every argument is an instance of some invalid argument forms, and we cannot say that every instance of every invalid form is invalid. (shrink)