Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Many scholars and activists seek to eliminate “race”—the word and the concept—from our vocabulary. Their claim is clear: because science has shown that racial essentialism is false and because the idea of race has proved virulent, we should do away with the concept entirely. Michael O. Hardimon criticizes this line of thinking, arguing that we must recognize the real ways in which race exists in order to revise our understanding of its significance. Rethinking Race provides a novel answer to (...) the question “What is race?” Pernicious, traditional racialism maintains that people can be judged and ranked according to innate racial features. Hardimon points out that those who would eliminate race make the mistake of associating the word only with this view. He agrees that this concept should be jettisoned, but draws a distinction with three alternative ideas: first, a stripped-down version of the ordinary concept of race that recognizes minimal physical differences between races but does not consider them significant; second, a scientific understanding of populations with shared lines of descent; and third, an acknowledgment of “socialrace” as a separate construction. Hardimon provides a language for understanding the ways in which races do and do not exist. His account is realistic in recognizing the physical features of races, as well as the existence of races in our social world. But it is deflationary in rejecting the concept of hierarchical or defining racial characteristics. Ultimately, Rethinking Race offers a philosophical basis for repudiating racism without blinding ourselves to reality. (shrink)

What we might usefully call “playing full-stop” and playing games plausibly figure in a well-lived life. Yet there are reasons to worry that the two not only do not naturally go hand in hand, but are in fact deeply opposed. In this essay I investigate the apparent tension between playing full-stop and playing competitive games. I argue that the nature of this tension is easily exaggerated. While there is a psychological tension between simultaneously engaging in earnest competitive game play and (...) playing fullstop, there is no logical contradiction between the two. Somewhat surprisingly, seeing how this tension is best understood teaches us something about the nature of willing an end and the “guise of the good.” With a resolution of the apparent tension between playing full-stop and playing competitive games, I turn to the practical worry that playing competitive games is destructive precisely for the very reasons it is opposed to playing full-stop. Here I develop a positive proposal to mitigate the tension between playing full-stop and playing competitive games. This proposal draws on the idea of “striving play” as recently developed by Thi Nguyen and some ideas from classical Stoicism. (shrink)

This book addresses such key ethical issues as euthanasia, the environment, biotechnology, abortion, the family, sexual ethics, and the distribution of health care resources. Michael Banner argues that the task of Christian ethics is to understand the world and humankind in the light of the credal affirmations of the Christian faith, and to explicate this understanding in its significance for human action through a critical engagement with the concerns, claims and problems of other ethics. He illustrates both the distinctiveness (...) of Christian convictions in relation to the above issues and also the critical dialogue with practices based on other convictions which this sense of distinctiveness motivates but does not prevent. The book's importance lies in its attempt to show the crucial difference which Christian belief makes to an understanding of these issues, whilst at the same time demonstrating some of the weaknesses and confusions of certain popular approaches to them. (shrink)

To most people it seems obvious that there are major mental differences between ourselves and other species, but there is considerable debate over exactly how special our minds are, in what respects, and which were the critical evolutionary events that have shaped us. Some researchers claimlanguage as a solely human, even defining, attribute, while others claim that only humans are truly conscious. These questions have been explored mainly by archaeologists and anthropologists until recently, but this volume aims to show what (...) psychologists have to say on the evolution of mind. The book begins with a thorough overview of what is known of the non-primate mind and its evolution. Following this, an international range of experts discuss in temporal sequence the human mind at various stages of evolution, beginning with the pre-hominids of 20 million years ago and ending withcontemporary human behaviour. Accessible to students and researchers alike in psychology, anthropology, evolution, archaeology, and ethology, The Descent of Mind provides a range of provocative answers to the timeless question of what it means to be human. (shrink)

Michael A. PetersBeijing Normal UniversityThe ancient concept of ‘self-cultivation’ with its roots in Confucianism and Hellenistic philosophy can also be utilised as tool for understanding the prac...

This article makes a contribution to interface criticism through the notion of chrono-design: the deliberate shaping of experiences of temporality and time through contemporary software techniques and digital technologies. This notion is articulated through discussions of network optimisation, user experience design, behavioural tracking, Hansen’s work on 21st-century media and Hayles’ framework of cognitive assemblages. In particular, the argument considers how contemporary user interfaces complicate conventional notions of the rational, self-reflexive subject by operating beyond consciousness at vast environmental dimensions and accelerated (...) micro-temporal speeds. These conditions, we argue, provide opportunities for new forms of behavioural suspense and captivation best exemplified through the figure of the trap. The politics and aesthetics of captivation, accordingly, should be considered as central to any expanded ecology of cognition. The article then concludes with a short demonstration of experimental uses of chrono-design methods applied critically to political economies of user tracking and data capture as a prompt for further interdisciplinary applied research in this domain. (shrink)

This study uses evidence from the press and from the parliamentary record to examine the extent to which, and the ways in which, people involved in the public debate over laboratory experiments on human embryos in Britain during the 1980s drew on images from science fiction. It is shown that negative images from science fiction were used in the debate, but that these images could be transformed into resources for defending, as well as attacking, this form of scientific endeavor. It (...) is also shown that other fictional structures were present in the debate and that both sides relied heavily on fictional components to justify their competing appraisals of embryo research. (shrink)

In his engaging essay, “Deconstructing the Mind” (1996: 3-90), Stephen Stich raises some very good questions and gives some pretty good answers. My aim in this paper is to give some answers of my own, drawing on earlier work, and to compare these answers with Stich’s.

In contexts of exposure to atypical stress or adversity, individual and collective resilience refers to the process of sustaining wellbeing by leveraging biological, psychological, social and environmental protective and promotive factors and processes. This multisystemic understanding of resilience is generating significant interest but has been difficult to operationalize in psychological research where studies tend to address only one or two systems at a time, often with a primary focus on individual coping strategies. We show how multiple systems implicated in human (...) resilience can be researched in the same study using a longitudinal, six-phase transformative sequential mixed methods study of 14- to 24-year-olds and their elders in two communities dependent on oil and gas industries. Data collection occurred over a 5-year period, and included: community engagement and the identification of youth health and well-being priorities; participatory youth-centric qualitative research using one-on-one semi-structured interviews and arts-based methods; survey of 500 youth at three time points to assess psychosocial health indicators and outcomes; collection of hair samples to assess stress biomarkers over time; youth-led ecological data collection and assessment of historical socio-economic development data; and community resource mapping with community elders. Analyzing data from these multiple systems will allow us to understand the interrelationship and impact of PPFPs within and across systems. To date, we have undertaken thematic and narrative qualitative analyses, and descriptive analyses of the preliminary ecological and survey data. As we proceed, we will combine these and grounded theory approaches with innovative techniques such as latent transition analysis and network analysis, as well as modeling of economic conditions and spatial analysis of human geographies to understand patterns of PPFPs and their inter-relationships. By analyzing the complexity of data collected across systems we are demonstrating the possibility of conducting multisystemic resilience research which expands the way psychological research accounts for positive development under stress in different contexts. This comprehensive examination of resilience may offer an example of how the study of resilience can inform socially and contextually relevant interventions and policies. (shrink)

Although America’s founders may have been inspired by the political thought of ancient Greece and Rome, the United States is more often characterized by its devotion to the pursuit of commerce. Some have even said that a modern commercial republic such as the United States unavoidably lowers its moral horizon to little more than a concern with securing peace and prosperity so that commerce can flourish. Michael Chan reconsiders this view of America through close readings of Aristotle and Alexander (...) Hamilton, showing that America at its founding was neither as modern nor as low as we have been led to believe. He challenges the virtue/commerce divide that dominates modern thought by demonstrating that the prevailing views of Aristotle and Hamilton on commerce reflect misleading half-truths. Chan first examines Aristotle’s views of economics as presented in the _Politics_, arguing that Aristotle was not as hostile to commerce as is commonly believed. He points out the philosopher’s belief in the value of commercial acquisition in the interest of supplying citizens with the “equipment of virtue,” citing Aristotle’s praise of commercial Carthage over agrarian but much-esteemed Sparta. Chan then turns to a detailed account of the political economy of Hamilton, a proponent of an advanced industrial republic modeled on Great Britain. While many take Hamilton’s advocacy of public credit, a national bank, and manufacturing as evidence of his rejection of classical republican thought in favor of modernity, Chan contends that Hamilton embraced a classically inspired economic statesmanship that transcended a concern with merely securing peace and prosperity. Leading the reader through the complexities of Hamilton’s thought, Chan shows that he intended commerce to pursue the wider classical goals of forming the character of citizens, establishing harmony and justice, and pursuing national greatness. Rather than attempting to brand Hamilton an Aristotelian, Chan seeks to incorporate into the study of Hamilton’s political economy what Aristotle himself regarded as the statesman’s characteristic virtue, prudence. By reflecting on Hamilton in the context of Aristotle’s own reflections on commerce, Chan casts him in a new light that cuts across the ongoing debate about liberal versus classical republican elements of the American founding. His cogent analysis also raises important questions regarding the American system as it is being challenged by conflicting worldviews. _Aristotle and Hamilton on Commerce and Statesmanship _makes a significant contribution to our understanding of both Hamiltonian thought and the moral worthiness of democratic capitalism. (shrink)

This paper discusses two possible difficulties with Catherine Lu’s powerful analysis of the moral response to our shared history of colonial evil; both of thesedifficulties stem from the rightful place of shame in that moral response. The first difficulty focuses on efficacy: existing states may be better motivated by shame atthe past than by a shared duty to bring about a just future. The second focuses on equity: it is, at the very least, possible that shame over past misdeeds ought (...) to bebrought into the conversation about present duties, in a manner more robust than Lu’s analysis allows. (shrink)

Written by well-known professor and author Michael Boylan, Morality and Global Justice is an accessible examination of the moral and normative underpinnings of ...

This book brings together researchers with cognitive-scientific and literary backgrounds to present innovative research in all three variations on the possible interactions between literary studies and cognitive science. The tripartite structure of the volume reflects a more ambitious conception of what cognitive approaches to literature are and could be than is usually encountered, and thus aims both to map out and to advance the field. The first section corresponds to what most people think of as "cognitive poetics" or "cognitive literary (...) studies": the study of literature by literary scholars drawing on cognitive-scientific methods, findings, and/or debates to yield insights into literature. The second section demonstrates that literary scholars needn't only make use of cognitive science to study literature, but can also, in a reciprocally interdisciplinary manner, use a cognitively informed perspective on literature to offer benefits back to the cognitive sciences. Finally, the third section, "literature in cognitive science", showcases some of the ways in which literature can be a stimulating object of study and a fertile testing ground for theories and models, not only to literary scholars but also to cognitive scientists, who here engage with some key questions in cognitive literary studies with the benefit of their in-depth scientific knowledge and training. (shrink)

In this work, Michael Steinmann provides a systematic reconstruction of Heidegger's thoughts on language, based on his early works on logic, on 'Being and Time' and 'On the Way to Language.

In this article the following criticisms of the essentialist conception of general term rigidity presented in the previous papers are considered and responded: the identity of designation conception of rigidity can provide us with a better alternative account for general term rigidity, and the essentialist conception fails to meet the condition of extensional adequacy, both because it over -and undergeneralizes. Against, it is claimed that the proposed definition of general term rigidity cannot feature in lost rigidity arguments against description theories (...) because it is circular, and then fails to do the primary work that rigidity is supposed to do, namely, distinguishing terms that are covered by a description theory from those that are not. As regards, after insisting that the essentialist view need not be commited to the condition of extensional adequacy, both charges of over- and undergeneralization are addressed: while the argumentation aimed at showing that some examples are cases of overgeneralization is rejected, the cases of undergeneralization are admitted to be still in need of a better explanation than the one given in Devitt. En este artículo se analizan y responden las siguientes objeciones a la concepción esencialista de la rigidez para términos generales contenidas en los artículos precedentes: la concepción de la rigidez como identidad de designación puede proporcionarnos una definición más adecuada del carácter rígido de los términos generales, y la concepción esencialista no puede cumplir con la condición de adecuación extensional, tanto debido a que sobregeneraliza como a que subgeneraliza. Contra, se sostiene que la definición alternativa propuesta no puede ser utilizada en argumentos basados en la pérdida de rigidez contra las teorías descriptivistas porque es circular; por consiguiente, fracasa en alcanzar el objetivo principal que se adscribe a la noción de rigidez, a saber, distinguir las expresiones que pueden ser explicadas en términos descriptivos de aquéllas para las cuales ello no es posible. En lo que concierne a, tras insistir en que la concepción esencialista no tiene por qué comprometerse con el requisito de adecuación extensional, se consideran las dos acusaciones mencionadas: mientras que se rechaza la argumentación tendiente a mostrar que ciertos ejemplos son casos de sobregeneralización, se acepta que algunos casos de subgeneralización requerirían de una explicación más adecuada que la presentada en Devitt. (shrink)

One afternoon in 1939, G. E. Moore held up his hands. He proceeded to make a certain gesture, first with his right hand and next with his left, while uttering the words, “Here is one hand and here is another.” Moore famously claimed to have thereby proved the existence of external things.

This paper is a response to John Schellenberg’s paper, “Skeptical Theism and Skeptical Atheism,” in which he raises objections to theistic belief that are supposed to cause special trouble for skeptical theists. In section I, I provide some clarificatory comments concerning skeptical theism. In section II, I evaluate an atheistic argument that Schellenberg finds particularly impressive. In section III, I examine the view Schellenberg calls ‘total evidence skepticism’ and consider its bearing on theistic belief. In the final section I consider (...) whether Schellenberg is right in thinking that skeptical theism commits one to total evidence skepticism and to some of the other skeptical theses he proposes. (shrink)

I’m not sure one even needs to think a state of affairs is true for us to take attitudinal pleasure in it. We surely take pleasure in imagining states of affairs. In such a case, we are well aware that the state of affairs that is the object of our enjoyment does not obtain. What is the proper account of the pleasure we take from imagining? I am fairly sure this is not a type of sensory pleasure. Would it make (...) sense to say that what S is attitudinally pleased by is the state of affairs consisting of S’s imagining p rather than p? I don’t think this will do. It seems possible for S to take pleasure in the imagined state of affairs, p, but not in the state of affairs of S’s imagining p. Consider the case of Chastity, who has had a puritanical upbringing. One day Chastity imagines a torrid romantic encounter with one of her co-workers. Quite in spite of herself, Chastity is pleased by the state of affairs which she merely imagines. But her upbringing has left its mark on her, so she feels very guilty about allowing her thoughts to run in such an unwholesome direction. Chastity is pained by the state of affairs consisting in her imagining the encounter. (shrink)

This paper looks at the prehistory of the foreclosure crisis in Cleveland, Ohio, in order to understand the effectiveness of civil society organizations in mitigating its impact on the city’s neighborhoods. Social theorists and movement activists have often postulated civil society as an authentic and voluntaristic realm in which we constitute and act on shared values. The voluntary nature of civil society organizations also, it is argued, make them more responsive, adaptable, and effective in meeting the needs of the communities (...) they operate in. The question is whether or not this has held true in the contemporary crisis. I find that in the 1970s, Cleveland’s community-based organizations were instrumental in securing resources from government and private philanthropies to deal with the urban crisis. The unintended result of this success was a general rationalization of Cleveland’s civil society around narrow practices and market-based conceptions of value. In the process, civil society was transformed into a political technology that solved various dilemmas of rule, but at the same time it was transformed into a civic monoculture that made the city especially vulnerable to foreclosure. A key implication of this analysis is that civil society has been transformed into an object and stake of urban politics and, as a result, it should not be expected to protect society against neoliberal institutional transformations. (shrink)

Philosophy for AS is an accessible textbook for the new 2014 AQA Advanced Subsidiary Philosophy syllabus. Structured closely around the AQA specification this textbook covers the two units, Epistemology and Philosophy of Religion, in an engaging and student-friendly way. With chapters on 'How to do philosophy', exam preparation providing students with the philosophical skills they need to succeed, and an extensive glossary to support understanding, this book is ideal for students studying philosophy. Each chapter includes: explanation and commentary of the (...) AQA anthology texts comprehension questions to test understanding discussion questions to generate evaluative argument 'going further' sections for advanced study cross-references to help students make connections bullet-point summaries of each topic. The companion website hosts a wealth of further resources, including PowerPoint slides, flashcards, further reading, weblinks and handouts, all structured to accompany the textbook. It can be found at www.routledge.com/cw/alevelphilosophy. (shrink)

Conversation analysis (CA) of children-adult—interaction in various contexts has become an established field of research. However,child therapyhas received limited attention in CA. In child therapy, the general psychotherapeutic practice of achieving empathy faces particular challenges. In relation to this, our contribution sets out three issues for investigation and analysis: the first one is that practices of achieving empathy must be preceded by efforts aiming to establish which kind of individualized conversation works with this child (Midgley,2006). Psychotherapy process researchers in adult (...) therapy (Stiles et al.,2015) have found that therapists “invent” a new therapy for each patient (Norcross and Wampold,2018). The second issue is that it can be difficult for adults to understand the ways in which children express their conflicts and issues. In particular, play activities in therapy, e.g., with dolls, can open up additional scenarios of interaction. The play scenario can be used to disclose unformulated problems masked in everyday and family interactions. The third issue is how to respect the child's higher degree of vulnerability, compared with adult patients. How is it communicated and dealt with in therapy? We present an interaction analysis of a single case study of the first 20 min of a child therapy session with an adopted girl aged 4 years brought to treatment because of “unexplainable rage.” The session was videotaped; parents granted permission. We analyze this session using an applied version of CA. In our analysis, we describe “doing contrariness,” as a conversational practice producing epistemic and affiliative disruptions, while “avoiding doing contrariness” and “remedying contrariness” are strategies for preserving or restoring the affiliative dimension of a relationship (in child therapy). We show how these practices operate in various modes and how they are used by both parties in our case study to variously aid and impedethe achievement of empathy and understanding. (shrink)

Since the beginning of UN peace operations, there has been discussion as to exactly how they should be carried out. Thus far, a just theory of UN peacekeeping operations has not yet been formed, in the way a Theory of Just War for waging war or a theory of police ethics for law enforcement in a peace context had been formed. The article discusses what a justified risk distribution between UN peacekeepers and local civilians should be. One of the points (...) of criticism of UN peacekeeping missions is the lack of protection of the local population in the course of an escalating situation. Familiar examples are the traumas of Rwanda (1994) and Srebrenica (1995). Discussing differences between UN peacekeeping missions, warfare, and law enforcement, it appears that peacekeepers have more in common with law enforcers than with combatants during wartime. Through the method of analogy and by applying some typically military ethics principles, the moral status of the UN peacekeepers is analyzed. Finally, a risk distribution analysis between UN peacekeepers and the local population is carried out, by offering a concise overview by philosophers of arguments for and against taking fewer risks by peacekeepers. The analysis reveals important deontological and consequentialist arguments. Taking also into consideration that transferring more risk to the peacekeeping troops alone does not mandatory lead to less exposure to risk of the vulnerable and innocent local civilians, it can be concluded that a more practical, virtuous, responsible risk calculation will be necessary at that point to find the best risk distribution. (shrink)

This essay identifies and explores an underappreciated win-win policy option that has the potential to address both the needs of refugees for resettlement and the labor demand of destination countries. Building upon provisions of the Model International Mobility Convention—a model convention endorsed by dozens of leading migration and refugee experts—and a program pioneered by Talent Beyond Boundaries, we explore how to scale up valuable measures for identifying job opportunities that can resettle refugees from asylum countries to destination countries. The latter (...) can benefit from the labor of refugees and thereby offer long-term refuge for populations in desperate need of resettlement. (shrink)

-/- Following the Mental Capacity Act (MCA) becoming law in 2005, and prior to its coming into force in 2007, there was a sustained effort to train support staff in the many social care settings where this new law was applicable. This training drive was necessary because, prior to the MCA, mental capacity law had evolved in the courts through consideration of a small number of cases that concerned serious medical treatments. These included the withdrawal of artificial nutrition and hydration (...) (Airedale NHS Trust v. Bland [1993]), blood transfusion (Re T [1993]), tissue donation (Re Y [1997]) and the provision of experimental medication for terminal illness (Simms v. Simms and another (2003)). In line with the Law Commission’s recommendations, the MCA extended the application of the law to ‘all acts in connection with care or treatment’ (MCA, Section 5), meaning that, overnight, social care settings and informal family care environments immediately fell within the scope of the legislation. (shrink)

According to Lee and Schwarz, the sensorimotor experience of cleansing involves separating one physical entity from another and grounds mental separation of one psychological entity from another. We propose that cleansing effects may result from symbolic cognition. Instead of viewing abstract meanings as emerging from concrete physical acts of cleansing, this physical act may be appended with pre-existing, symbolic meaning.