Previous research on emotion-induced blindness (EIB) argues emotional distractors capture attention in a bottom-up manner due to their physical and emotional salience. However, recent research has shown it is controversial whether EIB will be modulated by top-down factors. The present study further investigated whether the magnitude of EIB would be modulated by top-down factors, specifically the emotional relevance between tasks and distractors. Participants were divided into two groups having the same targets except for different task instructions. The orientation judgment group (...) was asked to judge the orientation of the target (an emotionally irrelevant task), and the emotion judgment group was required to judge the emotional valence of the target (an emotionally relevant task). It was found the emotional relevance between tasks and distractors has no modulation on the magnitudes of EIB in two groups when targets and distractors are from different categories (Experiment 1), but a modulation when they are from the same category (Experiment 2). Consequently, we contend top-down task relevance modulates the EIB effect and distractors’ priority is regulated by the emotional relevance between tasks and distractors. The current study holds attentional capture by stimulus-driven is unconditional in EIB, while attentional capture by goal-driven requires certain conditions. (shrink)

Fodor claims that cognitive modules can be thought of as constituting a psychological natural kind in virtue of their possession of most or all of nine specified properties. The challenge to this considered here comes from synaesthesia. Synaesthesia is a type of cross-modal association: input to one sensory modality reliably generates an additional sensory output that is usually generated by the input to a distinct sensory modality. The most common form of synaesthesia manifests Fodor's nine specified properties of modularity, and (...) hence, according to Segal (1997), it should be understood as involving an extra module. Many psychologists believe that synaesthesia involves a breakdown in modularity. After outlining how both theories can explain the manifestation of the nine alleged properties of modularity in synaesthesia, I discuss the two concepts of function which initially motivate the respective theories. I argue that only a teleological concept of function is properly able to adjudicate between the two theories. The upshot is a further application of so-called externalist considerations to mental phenomena. (shrink)

We investigate the processes underlying the feeling of control over one’s actions . Sense of agency may depend on internal motoric signals, and general inferences about external events. We used priming to modulate the sense of agency for voluntary and involuntary movements, by modifying the content of conscious thought prior to moving. Trials began with the presentation of one of two supraliminal primes, which corresponded to the effect of a voluntary action participants subsequently made. The perceived interval between movement and (...) effect was used as an implicit measure of sense of agency. Primes modulated perceived intervals for both voluntary and involuntary movements, but the modulation was greatest for involuntary movements. A second experiment showed that this modulation depended on prime–movement contiguity. We propose that sense of agency is based on a combination of internal motoric signals and external sensory evidence about the source of actions and effects. (shrink)

Liquid‐liquid phase separation (LLPS) has recently emerged as a possible mechanism that enables ubiquitin‐binding shuttle proteins to facilitate the degradation of ubiquitinated substrates via distinct protein quality control (PQC) pathways. Shuttle protein LLPS is modulated by multivalent interactions among their various domains as well as heterotypic interactions with polyubiquitin chains. Here, the properties of three different shuttle proteins (hHR23B, p62, and UBQLN2) are closely examined, unifying principles for the molecular determinants of their LLPS are identified, and how LLPS is connected (...) to their functions is discussed. Evidence supporting LLPS of other shuttle proteins is also found. In this review, it is proposed that shuttle protein LLPS leads to spatiotemporal regulation of PQC activities by mediating the recruitment of PQC machinery (including proteasomes or autophagic components) to biomolecular condensates, assembly/disassembly of condensates, selective enrichment of client proteins, and extraction of ubiquitinated proteins from condensates in cells. (shrink)

In this paper, by considering the notions of effect algebra and product effect algebra, we define the concept of effect module. Then we investigate some properties of effect modules, and we present some examples on them. Finally, we introduce some topologies on effect modules.

A theoretical divide exists on the study of the adapted psychological mechanisms underlying human culture. It has been said for instance that we evolved a brain for all seasons and that this is opposed to the framework of the modularity of mind. We approach the nature of these explanatory differences based on what we judge to be a misunderstanding with respect to the evolution of domain-specific modules. We underline the fact that the input-domain of a module and its ecological function (...) should not be conflated. We propose a more generous way of considering how evolutionary functions in mental architecture account for the possibility of general adaptations for cultural cognition. We show that modularity happens to be a good tool to research and decompose mechanisms with plastic functions such as in some forms of social learning. The idea of "modules for all seasons" is so vindicated. Existe una divisoria teórica en el estudio de los mecanismos psicológicos biológicamente adaptados que subyacen a la cultura humana. Se ha dicho, por un lado, que hemos evolucionado un cerebro para todas las estaciones, lo que se opone, por el otro, al marco de la modularidad de la mente. Consideramos la naturaleza de estas diferencias explicativas sobre la base de lo que nos parece un error de comprensión acerca de la evolución de módulos específicos de dominio. Subrayamos el hecho de que el dominio de entrada de un módulo y su función ecológica no deben ser confundidos. Proponemos una manera más generosa de considerar cómo las funciones evolutivas de la arquitectura mental pueden dar cuenta de la posibilidad de adaptaciones generales a la cognición cultural. Mostramos que la modularidad resulta ser un buen instrumento para investigar y descomponer mecanismos con funciones plásticas, como las que encontramos en algunas formas de aprendizaje social. De este modo, se defiende la idea de "módulos para todas las estaciones". (shrink)

The meaning that expressions take on particular occasions often depends on the context in ways which seem to transcend its direct effect on context-sensitive parameters. ‘Truth-conditional pragmatics’ is the project of trying to model such semantic flexibility within a compositional truth-conditional framework. Most proposals proceed by radically ‘freeing up’ the compositional operations of language. I argue, however, that the resulting theories are too unconstrained, and predict flexibility in cases where it is not observed. These accounts fall into this position because (...) they rarely, if ever, take advantage of the rich information made available by lexical items. I hold, instead, that lexical items encode both extension and non-extension determining information. Under certain conditions, the non-extension determining information of an expression e can enter into the compositional processes that determine the meaning of more complex expressions which contain e. This paper presents and motivates a set of type-driven compositional operations that can access non-extension determining information and introduce bits of it into the meaning of complex expressions. The resulting multidimensional semantics has the tools to deal with key cases of semantic flexibility in appropriately constrained ways, making it a promising framework to pursue the project of truth-conditional pragmatics. (shrink)

Journal of Mathematical Logic, Ahead of Print. We study classes of modules closed under direct sums, [math]-submodules and [math]-epimorphic images where [math] is either the class of embeddings, RD-embeddings or pure embeddings. We show that the [math]-injective modules of theses classes satisfy a Baer-like criterion. In particular, injective modules, RD-injective modules, pure injective modules, flat cotorsion modules and [math]-torsion pure injective modules satisfy this criterion. The argument presented is a model theoretic one. We use in an essential way stable independence (...) relations which generalize Shelah’s non-forking to abstract elementary classes. We show that the classical model theoretic notion of superstability is equivalent to the algebraic notion of a noetherian category for these classes. We use this equivalence to characterize noetherian rings, pure semisimple rings, perfect rings and finite products of finite rings and artinian valuation rings via superstability. (shrink)

Public “upstream engagement” and other approaches to the social control of technology are currently receiving international attention in policy discourses around emerging technologies such as nanotechnology. To the extent that such approaches hold implications for research and development (R&D) activities, the distinct participation of scientists and engineers is required. The capacity of technoscientists to broaden the influences on R&D activities, however, implies that they conduct R&D differently. This article discusses the possibility for more reflexive participation by scientists and engineers in (...) the internal governance of technology development. It reviews various historical attempts to govern technoscience and introduces the concept of midstream modulation, through which scientists and engineers, ideally in concert with others, bring societal considerations to bear on their work. (shrink)

(2013). Evolutionary modules and Bayesian facilitation: The role of general cognitive resources. Thinking & Reasoning: Vol. 19, No. 1, pp. 27-53. doi: 10.1080/13546783.2012.713177.

The adaptation-by-binding account and the arousal-biased competition model suggest that emotional arousal increases binding effects for transient links between stimuli and responses. Two highly-powered, pre-registered experiments tested whether transient stimulus-response bindings are stronger for high versus low arousing stimuli. Emotional words were presented in a sequential prime-probe design in which stimulus relation, response relation, and stimulus arousal were orthogonally manipulated. In Experiment 1 (N = 101), words with high and low arousal levels were presented individually in prime and probe displays. (...) In Experiment 2 (N = 170), a high arousing affective word was presented simultaneously with a neutral word during the prime display; in the subsequent probe display, either the arousing or the neutral word repeated or a different high versus low arousal word was shown. Data from both experiments did not demonstrate a modulation of SRBR effects by stimulus arousal and SRBR effects were of equal magnitude for word stimuli of high and low arousal levels. These null results are not in line with binding accounts that hypothesise a modulatory influence of emotional arousal on perception-action binding. (shrink)

Fibring is recognized as one of the main mechanisms in combining logics, with great signicance in the theory and applications of mathematical logic. However, an open challenge to bring is posed by the collapsing problem: even when no symbols are shared, certain combinations of logics simply collapse to one of them, indicating that bring imposes unwanted interconnections between the given logics. Modulated bring allows a ner control of the combination, solving the collapsing problem both at the semantic and deductive levels. (...) Main properties like soundness and completeness are shown to be preserved, comparison with bring is discussed, and some important classes of examples are analyzed with respect to the collapsing problem. (shrink)

Hypnosis is considered a unique tool capable of modulating cognitive processes. The extent to which hypnotic suggestions intervenes is still under debate. This study was designed to provide a new insight into this issue, by focusing on an unintentional emotional process: attentional bias. In Experiment 1, highly suggestible participants performed three sessions of an emotional Stroop task where hypnotic suggestions aiming to increase and decrease emotional reactivity towards emotional stimuli were administered within an intra-individual design. Compared to a baseline condition (...) (without hypnotic suggestion), a significant increase in attentional bias was found when a hypnotic suggestion to increase emotional reactivity was administered. In contrast, the bias was eliminated when a suggestion to decrease emotional reactivity was administered. Experiment 2 investigated the effect of session repetition on attentional bias across three successive experimental sessions without hypnosis, and showed that the emotional Stroop effect did not vary across sessions. Hence, session repetition could not account for part of the modulation of attentional bias in Experiment 1. Taken together, the results suggest that specific hypnotic suggestions can influence elicitation of unintentional emotional processing. The implications are discussed regarding the locus of intervention of hypnotic suggestion in cognitive and emotional processes. (shrink)

How does the brain generate our experience of being in control over our actions and their effects? Here, we argue that the perception of events as self-caused emerges from a comparison between anticipated and actual action-effects: if the representation of an event that follows an action is activated before the action, the event is experienced as caused by one’s own action, whereas in the case of a mismatch it will be attributed to an external cause rather than to the self. (...) In a subliminal priming paradigm we show that participants overestimated how much control they had over objectively uncontrollable stimuli, which appeared after free- or forced-choice actions, when a masked prime activated a representation of the stimuli immediately before each action. This prime-induced control-illusion was independent from whether primes were consciously perceived. Results indicate that the conscious experience of control is modulated by unconscious anticipations of action-effects. (shrink)

Fictional characters present a problem for semantic theorists. One approach to this problem has been to maintain realism regarding fictional characters, that is to claim that fictional characters exist. In this way names originating from fiction have designata. On this approach the problem of negative existentials is more pressing than it might otherwise be since an explanation must be given as to why we judge them true when the names occurring within them designate existing objects. So, realists must explain the (...) intuitive truth of such statements. Some realists have appealed to pragmatics to explain this, but have not developed these positions fully. What follows is an original account of negative existentials based on the pragmatic process of modulation. Modulation affects the meaning of ‘exists’ such that its extension is merely those things that exist physically. It is then argued that the modulation approach provides a more natural account of the intuitive truth of negative existentials involving fictional characters than an account based on conversational implicatures. Finally, the modulation account is defended against objections presented against similar accounts. (shrink)

Moderate physiological or emotional arousal induced after learning modulates memory consolidation, helping to distinguish important memories from trivial ones. Yet, the contribution of subjective awareness or interpretation of arousal to this effect is uncertain. Alexithymia, which is an inability to describe or identify one’s emotional and arousal states even though physiological responses to arousal are intact, provides a tool to evaluate the role of arousal interpretation. Participants scoring high and low on alexithymia learned a list of 30 words, followed by (...) immediate recall. Participants then saw either an arousing or neutral video . Memory was tested 24-h later. Physiological response to arousal was comparable between groups, but subjective response to arousal was impaired in high alexithymia. Yet, delayed word recognition was enhanced by arousal regardless of alexithymia status. Thus, subjective response to arousal, i.e., cognitive appraisal, was not necessary for memory modulation to occur. (shrink)

In response to an increasing amount of policy papers stressing the need for integrating social and ethical aspects in Research and Development (R&D) practices, science studies scholars have conducted integrative research and experiments with science and innovation actors. One widely employed integration method is Midstream Modulation (MM), in which an ‘embedded humanist’ interacts in regular meetings with researchers to engage them with the social and ethical aspects of their work. While the possibility of using MM to enhance critical reflection (...) has been demonstrated in academic settings, few attempts have been made to examine its appropriateness in industry. This paper describes the outcomes of a case study aiming to find out firstly whether MM can effectively be deployed to encourage and facilitate researchers to actively include social and ethical aspects in their daily R&D practice, and secondly to what extent the integration activities could form an integral part of the engaged industrial researchers’ professional activities. Our data show that after MM, researchers display increased reflexive awareness on the social and ethical aspects of their work and acknowledge the relevance and utility of such aspects on their daily practice. Also, all participants considered actively reflecting on social and ethical aspects to be part of their work. Future research on the role of MM in industrial settings could focus on how to embed social and ethical integration as a regular part of innovation practice. We suggest that one possibility would be through aligning social and ethical aspects with innovation Key Performance Indicators. (shrink)

In response to an increasing amount of policy papers stressing the need for integrating social and ethical aspects in Research and Development (R&D) practices, science studies scholars have conducted integrative research and experiments with science and innovation actors. One widely employed integration method is Midstream Modulation (MM), in which an ‘embedded humanist’ interacts in regular meetings with researchers to engage them with the social and ethical aspects of their work. While the possibility of using MM to enhance critical reflection (...) has been demonstrated in academic settings, few attempts have been made to examine its appropriateness in industry. This paper describes the outcomes of a case study aiming to find out firstly whether MM can effectively be deployed to encourage and facilitate researchers to actively include social and ethical aspects in their daily R&D practice, and secondly to what extent the integration activities could form an integral part of the engaged industrial researchers’ professional activities. Our data show that after MM, researchers display increased reflexive awareness on the social and ethical aspects of their work and acknowledge the relevance and utility of such aspects on their daily practice. Also, all participants considered actively reflecting on social and ethical aspects to be part of their work. Future research on the role of MM in industrial settings could focus on how to embed social and ethical integration as a regular part of innovation practice. We suggest that one possibility would be through aligning social and ethical aspects with innovation Key Performance Indicators. (shrink)

This paper studies a family of monotonic extensions of first-order logic which we call modulated logics, constructed by extending classical logic through generalized quantifiers called modulated quantifiers. This approach offers a new regard to what we call flexible reasoning. A uniform treatment of modulated logics is given here, obtaining some general results in model theory. Besides reviewing the “Logic of Ultrafilters”, which formalizes inductive assertions of the kind “almost all”, two new monotonic logical systems are proposed here, the “Logic of (...) Many” and the “Logic of Plausibility”, that characterize assertions of the kind “many”, and “for a good number of”. Although the notion of simple majority (“more than half”) can be captured by means of a modulated quantifier semantically interpreted by cardinal measure on evidence sets, it is proven that this system, although sound, cannot be complete if checked against the intended model. This justifies the interest on a purely qualitative approach to this kind of quantification, what is guaranteed by interpreting the modulated quantifiers as notions of families of principal filters and reduced topologies, respectively. We prove that both systems are conservative extensions of classical logic that preserve important properties, such as soundness and completeness. Some additional perspectives connecting our approach to flexible reasoning through modulated logics to epistemology and social choice theory are also discussed. (shrink)

In Brasil, a real mixing of populations is prevented by the proclamation of a « grey People », artificially invented and imposed by force in order to stabilize the Nation-State. Black and indigenous movements today have to reclaim « race » in their struggle for real equality, in order to impose policies of affirmative action, in the university as well as elsewhere.

ABSTRACTThe objective of this module is to inform you on issues of concern for Research Ethics Committee members and investigators during the review process. The many guidelines on research ethics, including those from the South African Department of Health and the World Health Organisation, will be referred to extensively to educate you on the requirements of Research Ethics Committees. The evolution of the review process in South Africa will be detailed.

In this paper, considering $L$-algebras, which include a significant number of other algebraic structures, we present a definition of modules on $L$-algebras ($L$-modules). Then we provide some examples and obtain some results on $L$-modules. Also, we present definitions of prime ideals of $L$-algebras and $L$-submodules (prime $L$-submodules) of $L$-modules, and investigate the relationship between them. Finally, by proving a number of theorems, we provide some conditions for having prime $L$-submodules.

ABSTRACT This module is designed to sensitise you to the special needs of participants who belong to populations that are more vulner.

While research to improve memory or counter decay caused by neurodegenerative diseases has a fairly long history, scientific attempts to erase memories are very recent. The use of non-invasive brain stimulation for memory modulation represents a new and promising application for the treatment of certain disorders [such as Post-Traumatic Stress Disorder ]. However, numerous ethical issues are related to memory intervention. In particular, the possibility of using forms of non-invasive brain stimulation requires to distinguish treatment interventions from the enhancement (...) of the healthy. Furthermore, a range of important societal and legal concerns arise when manipulating memories. In this short contribution, we address some of the most significant ethical, social, and legal implications surrounding the application of memory-modulation techniques and offer a series of reflections and considerations, which we hope can be of use to guide -and perhaps regulate- their potential, future implementation in society. (shrink)

This article began as a review of a conference, organized by Gerhard Schlosser, entitled “Modularity in Development and Evolution.” The conference was held at, and sponsored by, the Hanse Wissenschaftskolleg in Delmenhorst, Germany in May, 2000. The article subsequently metamorphosed into a literature and concept review as well as an analysis of the differences in current perspectives on modularity. Consequently, I refer to general aspects of the conference but do not review particular presentations. I divide modules into three kinds: structural, (...) developmental, and physiological. Every module fulfills none, one, or multiple functional roles. Two further orthogonal distinctions are important in this context: module-kinds versus module-variants-of-a-kind and reproducer versus nonreproducer modules. I review criteria for individuation of modules and mechanisms for the phylogenetic origin of modularity. I discuss conceptual and methodological differences between developmental and evolutionary biologists, in particular the difference between integration and competition perspectives on individualization and modular behavior. The variety in views regarding modularity presents challenges that require resolution in order to attain a comprehensive, rather than a piecemeal and fragmentary, evolutionary developmental biology. (shrink)

Midstream modulation is a form of public engagement with science which benefits from strategic application of science and technology studies (STS) insights accumulated over nearly 20 years. These have been developed from STS researchers’ involvement in practical engagement processes and research with scientists, science funders, policy and other public stakeholders. The strategic aim of this specific method, to develop what is termed second-order reflexivity amongst scientist-technologists, builds upon and advances earlier more general STS work. However this method is focused (...) and structured so as to help generate such reflexivity—over the ‘upstream’ questions which have been identified in other STS research as important public issues for scientific research, development and innovation—amongst practising scientists-technologists in their specialist contexts (public or private, in principle). This is a different focus from virtually all such previous work, and offers novel opportunities for those key broader issues to be opened up. The further development of these promising results depends on some important conditions such as identifying and engaging research funders and other stakeholders like affected publics in similar exercises. Implementing these conditions could connect the productive impacts of midstream modulation with wider public engagement work, including with ‘uninvited’ public engagement with science. It would also generate broader institutional and political changes in the larger networks of institutional actors which constitute contemporary technoscientific innovation and governance processes. All of these various broader dimensions, far beyond the laboratory alone, need to be appropriately open, committed to democratic needs, and reflexive, for the aims of midstream modulation to be achieved, whilst allowing specialists to work as specialists. (shrink)

ABSTRACTThis module examines ethical debates about the level of care that should be provided to human research participants. Particular attention is placed on the question of what should be considered an ethically acceptable control arm. You will also learn what relevant international and domestic regulatory documents say about standards of care.

ABSTRACTThe objective of this module is to familiarise you with the concept of informed consent, its ethical basis, its elements, and typical problems that are encountered even by the most well intentioned researchers when trying to achieve genuine informed consent.

The objective of this module is to cover ground that was not covered in-depth in any of the other modules, including: scientific misc.

We argue that the pivotal role assigned by Northoff to the principle of top-down modulation in catatonia might successfully be applied to other symptoms of schizophrenia, for example, hallucinations. Second, we propose that Northoff's account would benefit from a more comprehensive analysis of the cognitive level of explanation. Finally, contrary to Northoff, we hypothesize that “top-down modulation” might play as important a role as “horizontal modulation” in affective-behavioral alterations.

Visual modules can be viewed as expressions of a marked analytic attitude in the study of vision. In vision psychology, this attitude is accompanied by hypotheses that characterize how visual modules are thought to operate in perceptual processes. Our thesis here is that there are what we call “intrinsic reasons” for the presence of such hypotheses in a vision theory, that is, reasons of a deductive kind, which are imposed by the partiality of the basic terms in the definition of (...) a module, and by peculiar characteristics of those terms. Specifically, we discuss three hypotheses of functional attributes: successive stages in the action of modules, residual indeterminacy of their effects, and the role of prior constraints. For each of the three, we indicate its occurrence in perceptual psychology, explain corresponding intrinsic reasons, and illustrate such reasons with examples. (shrink)

We argue against the dominant view in the literature that concepts are modulated in lexical modulation. We also argue against the alternative view that ‘grab bags’ of information that don’t determine extensions are the starting point for lexical modulation. In response to the problems with these views we outline a new model for lexical modulation that dispenses with the assumption that there is a standing meaning of a general term that is modified in the cases under consideration. (...) In applying general terms we intend to conform with our linguistic ancestors and in doing so we take facts about the referents of these terms for granted. In cases of lexical modulation we become aware of facts we took for granted and we need to change the facts we take for granted in order to see ourselves as continuing in a practice. These changes result in utterances of the general term referring to different properties. In general, concepts are neither the starting point for lexical modulation nor the standing meanings of words. (shrink)

Acceptable analyticities, i.e. contradictions or tautologies, constitute problematic evidence for the idea that language includes a deductive system. In recent discussion, two accounts have been presented in the literature to explain the available evidence. According to one of the accounts, grammatical analyticities are accessible to the system but a pragmatic strengthening repair mechanism can apply and prevent the structures from being actually interpreted as contradictions or tautologies. The proposed data, however, leaves it open whether other versions of the meaning (...) class='Hi'>modulation operation are required. Novel evidence we present argues that a loosening version of the repair mechanism must be available. Our observation concerns acceptable lexical contradictions that cannot be rescued if only a strengthening version of the pragmatic strategy is available. (shrink)

Electric-mechanical equipment manufacturing industries focus on the implementation of intelligent manufacturing systems in order to enhance customer services for highly customized machines with high-profit margins such as electric power transformers. Intelligent manufacturing consists in using supply chain data that are integrated for smart decision making during the production life cycle. This research, in cooperation with a large electric power transformer manufacturer, provides an overview of critical intelligent manufacturing technologies. An ontology schema forms the terminology relationships needed to build two intelligent (...) supply chain management modules for the IM system demonstration. The two core modules proposed in this research are the intelligent supplier selection and component ordering module and the product quality prediction module. The intelligent supplier selection and component ordering module dispatches orders that match the best options of suppliers based on combined analytic hierarchy process analysis and multiobjective integer optimization. In the case study, the intelligent supplier selection and component ordering module demonstrates several acceptable Pareto solutions based on strict constraints, which is a very challenging task for decision makers without assistance. The second module is the product quality prediction module which uses multivariate regression and ARIMA to predict the quality of the finished products. Results show that the R square values are very close to 1. The module shortens the time for the company to accurately judge whether the two semifinished iron cores for the product meet the quality requirements. The component supplier selection module and the finished product quality prediction module developed in this research can be extended to other IM systems for general high-end equipment manufacturers using mass customization. (shrink)

Proponents of the dominant paradigm in evolutionary psychology argue that a viable evolutionary cognitive psychology requires that specific cognitive capacities be heritable and “quasi-independent” from other heritable traits, and that these requirements are best satisfied by innate cognitive modules. We argue here that neither of these are required in order to describe and explain how evolution shaped the mind.

Autism spectrum disorders (ASD) are thought to result in part from altered cortical excitatory-inhibitory balance; this pathophysiology may impact the generation of oscillations on EEG. We investigated premotor-parietal cortical physiology associated with praxis, which has strong theoretical and empirical associations with ASD symptomatology. 25 children with high-functioning ASD (HFA) and 33 controls performed a praxis task involving the pantomiming of tool use, while EEG was recorded. We assessed task-related modulation of signal power in alpha and beta frequency bands. Compared (...) with controls, subjects with HFA showed 27% less left central (motor/premotor) beta (18-22 Hz) event-related desynchronization (ERD) (p = 0.030), as well as 24% less left parietal alpha (7-13 Hz) ERD (p = 0.046). Within the HFA group, blunting of central ERD attenuation was associated with impairments in clinical measures of praxis imitation (r = -0.4; p = 0.04) and increased autism severity (r = 0.48; p = 0.016). The modulation of central beta activity is associated, among other things, with motor imagery, which may be necessary for imitation. Impaired imitation has been associated with core features of ASD. Altered modulation of oscillatory activity may be mechanistically involved in those aspects of motor network function that relate to the core symptoms of ASD. (shrink)