This article is focused on the audience and the transcripts of Friedrich Schleiermacher’s theological and philosophical lectures at the universities of Halle and Berlin between 1804/05 and 1834. It gives a summary and a characterization of the attached list, which contains in alphabetical order the known audience members and their transcripts of Schleiermacher’s lectures. The aim of this article is to advance the theological and philosophical research into the history of ideas in the early nineteenth century, esp. of Schleiermacher’s academic (...) work, with respect to his lecture style, the (academic) biography of his audience, the relation between the spoken (lecture) and the written word (transcript), as well as the relationship of the students amongst themselves. (shrink)

Thomas Holden presents a fascinating study of theories of matter in the seventeenth and eighteenth centuries. These theories were plagued by a complex of interrelated problems concerning matter's divisibility, composition, and internal architecture. Is any material body infinitely divisible? Must we posit atoms or elemental minima from which bodies are ultimately composed? Are the parts of material bodies themselves material concreta? Or are they merely potentialities or possible existents? Questions such as these -- and the press of subtler questions (...) hidden in their amibiguities -- deeply unsettled philosophers of the early modern period. They seemed to expose serious paradoxes in the new world view pioneered by Galileo, Descartes, and Newton. The new science's account of a fundamentally geometrical Creation, mathematicizable and intelligible to the human inquirer, seemed to be under threat. This was a great scandal, and the philosophers of the period accordingly made various attempts to disarm the paradoxes. All the great figures address the issue: most famously Leibniz and Kant, but also Galileo, Hobbes, Newton, Hume, and Reid, in addition to a crowd of lesser figures. Thomas Holden offers a brilliant synthesis of these discussions and presents his own overarching interpretation of the controversy, locating the underlying problem in the tension between the early moderns' account of material parts on the one hand and the program of the geometrization of nature on the other. (shrink)

The rise and persistence of a commercial model of healthcare and the potential shift towards the commodification of dental services, provided to consumers, should provoke thought about the nature and purpose of dentistry and whether this paradigm is cause for concern. Within this article, whether dentistry is a commodity and the legitimacy of dentistry as a business is explored and assessed. Dentistry is perceived to be a commodity, dependent upon the context of how services are to be provided and the (...) interpretation of the patient–professional relationship. Commercially-focused practices threaten the fiduciary nature of the interaction between consumer and provider. The solution to managing commercial elements within dentistry is not through rejection of the new paradigm of the consumer of dental services, but in the rejection of competitive practices, coercive advertising and the erosion of professional values and duty. Consumerism may bring empowerment to those accessing dental services. However, if the patient–practitioner relationship is reduced to a mere transaction in the name of enhanced consumer participation, this empowerment is but a myth. (shrink)

The growth of esports as a recognized, organized, competitive activity in North America and Europe has evolved steadily from one of the most prominent sport industries in several Asian countries. Esports, which is still pursuing a widely accepted governance structure, has struggled to control the factors that typically act as a breeding ground for sport corruption. Within the esports industry, there is alleged widespread use of both prescription and off-label use of stimulants, such as modafinil, methylphenidate, and dextroamphetamine. Anti-doping policy (...) implementation in this environment may result in either the abuse of the Therapeutic Use Exemptions system or excluding too many competitors who have a legitimate need for these medications. In this paper, we contextualize esports and substance use within this emerging industry. Subsequently, we outline the specific challenges faced by esports organizations in crafting policies to address PEDs—one of the industry’s most pressing issues. Furt... (shrink)

I explore some of the challenges involved in establishing the intersubjective dynamic as the foundation for a normatively charged philosophy of history. I seek in addition to highlight the value of Levinas’ work for the field of recognition studies. Levinas in effect offers a transitional model of recognition between Kojeve and Honneth, and as such his work harbors the potential for addressing some of the difficulties which beset the work of both when it comes to formulating an understanding of recognition (...) which is capable of explaining historical transformation and of serving as a standard for the critique of historical practices. (shrink)

Transcendent Individual is an anthropological account of individual creativity and its conscious engagement in society. Drawing widely on ethnographic and theoretic material, and bringing into debate a range of voices--Nietzsche, Wilde and Forster, Bateson and Gerald Edelman, George Steiner, Richard Rorty and John Berger, Edmund Leach and Anthony Cohen--the book approaches individuality in terms of a range of issues: biological integrity, consciousness, agency, democracy, discourse, knowledge, consumerism, globalism and play.

Hume regards the ‘absolute’ necessity attending demonstrable truths as simply an expression of our imaginative blocks, and thereby avoids any commitment to a mind-independent and extra-empirical domain of absolute modal properties and facts. I develop this expressivist interpretation of Hume’s metaphysics of absolute modality, situate it against a wider understanding of Hume’s philosophy of language, and defend it against some recent objections.

Nach dem Erscheinen der beiden Vorlesungsbände zur Psychologie (KGA II/13) und zur Ästhetik (KGA II/14) im Rahmen der Kritischen Gesamtausgabe der Werke Friedrich Daniel Ernst Schleiermachers liegen verbindliche und vollständige Textgrundlagen vor, die dazu einladen, sich den anthropologischen und ästhetischen Themen Schleiermachers neu zuzuwenden. Von DER Anthropologie Schleiermachers kann nicht gesprochen werden. Er selbst hat eine solche Disziplin nur randständig und wenig konturiert beschrieben. Gleichwohl durchziehen Menschenbildannahmen sein philosophisches und theologisches Werk. Entsprechend breit fächern sich die Beiträge auf und beleuchten (...) anthropologische Fragen aus pädagogischer, theologischer oder psychologischer Sicht und bauen Brücken zu zeitgenössischen (etwa Friedrich Heinrich Jacobi) oder späteren (Ernst Cassirer) Entwürfen. Ästhetik ist die letzte philosophische Disziplin, die Schleiermacher in den Zyklus seiner philosophischen Vorlesungen aufnahm, wobei er über ihre ethische Fundierung bereits in seinen ersten Hallenser Vorlesungen reflektierte. Die Beiträge zur Ästhetik schlagen einen Bogen von der Urbildtheorie, der Praktischen Theologie und der Musikrezeption Schleiermachers bis hin zur Kunsttheorie von Aby Warburg. (shrink)

THE ARTICLE CONSIDERS HOW THE CONCEPTION OF PSYCHOSOMATIC DISORDER FITS INTO THE DUALISTIC AND MONISTIC VIEWS OF DOCTORS ON THE MIND-BODY RELATIONSHIP, AND POINTS OUT HOW THE DIFFICULTY OF FITTING IT INTO THE CURRENT KIND OF MONISM WOULD BE LESSENED IF PSYCHOSOMATIC DISORDERS WERE DEFINED AS SOMATIC SYMPTOMS WHICH CAN BE SUCCESSFULLY TREATED BY METHODS USED TO TREAT PSYCHIC SYMPTOMS.

A well-worn French proverb pronounces ‘tout comprendre c’est tout pardonner’ (‘to understand all is to forgive all’). Is forgiveness the inevitable consequence of social scientific understanding of the actions and lives of perpetrators of serious wrongdoing? Do social scientific explanations provide excuses or justifications for the perpetrators of the actions that the explanations purport to explain? In this essay, I seek clarification of these intertwined explanatory and moral questions.

Nigel Blake; Church Schools, Religious Education and the Multi-ethnic Community: a reply to David Aspin, Journal of Philosophy of Education, Volume 17, Issue 2.

There is no greater testament to Emmanuel Levinas' reputation as an enigmatic thinker than in his meditations on eschatology and its relevance for contemporary thought. Levinas has come to be seen as a principal representative in Continental philosophy - alongside the likes of Heidegger, Benjamin, Adorno and Zizek - of a certain philosophical messianism, differing from its religious counterpart in being formulated apparently without appeal to any dogmatic content. To date, however, Levinas' messianism has not received the same detailed attention (...) as other aspects of his wide ranging ethical vision. Terence Holden attempts to redress this imbalance, tracing the evolution of the messianic idea across Levinas' career, emphasising the transformations or indeed displacements which this idea undergoes in taking on philosophical intelligibility. He suggests that, in order to crack the enigma which this idea represents, we must consider not only the Jewish tradition from which Levinas draws inspiration, but also Nietzsche, who ostensibly would represent the greatest rival to the messianic idea in the history of philosophy, with his notion of the ‘parody' of messianism. >. (shrink)

Modern western political thought revolves around globality, focusing on the partitioning and the connecting up of the earth’s surface. But climate change and the Anthropocene thesis raise pressing questions about human interchange with the geological and temporal depths of the earth. Drawing on contemporary earth science and the geophilosophy of Deleuze and Guattari, this article explores how geological strata are emerging as provocations for political issue formation. The first section reviews the emergence – and eventual turn away from – concern (...) with ‘revolutions of the earth’ during the 18th- and 19th-century discovery of ‘geohistory’. The second section looks at the subterranean world both as an object of ‘downward’ looking territorial imperatives and as the ultimate power source of all socio-political life. The third section weighs up the prospects of ‘earth system governance’. The paper concludes with some general thoughts about the possibilities of ‘negotiating strata’ in more generative and judicious ways. (shrink)

John Dewey stated that ‘[h]owever far apart philosophy and educational theory may later have become, in their beginnings they were strictly identical.' Dewey's ‘progressivism' in Democracy and Education rests on this communion. A self-reflective philosophical education by the community, about the community, for the community, would create the conditions for the advance of social justice. But new progressive ideas championing redistributive justice might appear to be in worryingly short supply. That is one reason, among many, why Philip Kitcher’s The Main (...) Enterprise of the World is to be welcomed. His rethinking about education amounts to a radical re-education of our thinking about social justice, seeking redistribution of wealth, reduction of privilege, and a redefinition of what is valuable for people and planet in regard to production, distribution, and consumption. I will summarize his book and offer critical thoughts on it relating to three themes: the relation of his proposed Deweyan Society to some current and powerful criticisms of Western rationality; his proposals for classrooms; and the extent to which its own pragmatic philosophical justifications are open to deeper philosophical and educational significance. (shrink)

Nigel Blake; Intellectual Freedom and the Universities: a reply to Anthony O'Hear, Journal of Philosophy of Education, Volume 22, Issue 2, 30 May 2006, Pages 25.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Materialism from Hobbes to Locke by Stewart DuncanThomas HoldenStewart Duncan. Materialism from Hobbes to Locke. Oxford: Oxford University Press, 2022. Pp. 248. Hardback, $80.00.Stewart Duncan’s Materialism from Hobbes to Locke presents a tightly focused study of the seventeenth-century English debate over materialism in the philosophy of mind, from Hobbes’s uncompromising rejection of incorporeal substance as a contradiction in terms through to Locke’s cautious calibrations around the metaphysics of (...) mind and body. Along the way, Duncan considers Hobbes’s exchange with Descartes and examines the contributions of a handful of mid- and late seventeenth-century figures, including those of the Cambridge Platonists Henry More and Ralph Cudworth writing in scandalized reaction to Hobbes, and that of the more bohemian figure Margaret Cavendish, with her own panpsychist variation of materialism. An epilogue considers some of Locke’s more radical self-described followers in the early eighteenth century, with their own iteration of materialist-inclined pseudo-Lockean speculations.Duncan’s book will take its place as an essential study of the debate over materialism and the metaphysics of mind in early modern England. It is particularly illuminating when examining the ways in which Locke’s own treatment of materialism is shaped both positively and negatively by the intervening responses to Hobbes. Locke himself is not always terribly scrupulous about registering his own influences, and—at least when read from our distance—can seem to present his monumental Essay Concerning Human Understanding more as an achievement of epic psychological introspection and experimental self-examination than a series of moves in a complex dialogue with other contemporary figures. Duncan brings significant parts of that subtextual dialogue back into view, shedding light on Locke’s cautious agnosticism about materialism through plausible treatment of his likeliest sources. In attending closely to Locke’s own influences, Materialism from Hobbes to Locke makes a substantial contribution to the project of naturalizing Locke that one also sees advanced in recent scholarship by Hannah Dawson, Nicholas Jolley, and Antonia LoLordo. And Duncan’s approach yields striking results, as when he intervenes compellingly in the well-known debate between Jonathan Bennett and Michael Ayers over whether Locke’s theory of substance commits him to a pure propertyless substratum or merely a material microstructure that is responsible for the empirically observable properties of objects. Ayers had rejected the pure substratum view as absurd and unthinkable for Locke. But Duncan shows that More had explicitly endorsed just such a theory and was very plausibly one of Locke’s sources. The hypothesis of a pure propertyless substratum was then at least a thinkable option for Locke, and it is arguable that his own view of substance was in part inspired by More.Throughout the book, Duncan’s spotlight is on the question of the metaphysical basis of the human mind, consciousness, and thought, together with the analogous question for other minds, whether animal, angelic, or divine. Most of the time, this focus on the metaphysics of mind tracks well with the leading concerns and arguments of the figures under discussion, and it helps give Duncan’s history an engaging narrative course. But it is arguable that for Hobbes, at least, materialism was as much a research program and methodological manifesto for what we would now call the natural sciences as it was an answer to a question about the nature of the conscious mind. Questions about the explanatory reach of materialism in natural philosophy—including questions about the nature of space and time, cohesion, elasticity, the existence of a vacuum, and the nature of active forces and materially penetrable fields—arise here only obliquely, if at all, as and when they inform the central question of mind.Duncan’s discussion is circumscribed in one other way as well. The “from Hobbes to Locke” of his title should not be taken as simply declaring the book’s chronological framework—as specifying the time period to be examined, bookended by each of these important figures. It should also be read causally, developmentally, genealogically: from Hobbes to Locke. Duncan’s book “is about the reactions to Hobbes’s materialism” (5, emphasis added), particularly the reactions in England (and... (shrink)

Modernity has imposed on many of us, and perhaps especially on academics, a habit of silence with regard to what John Rawls called deeply held ‘comprehensive’ moral beliefs. According to Rawls and his many disciples, the survival of liberalism depends upon the bracketing of comprehensive beliefs whenever we step into the public sphere. And in the field of higher education, that would have to include the classroom, the lab, the library carrel, the hotel conference suites where we confer and exchange (...) ideas, as well as the vast academic publishing apparatus. I would like to call attention to the way that the supposed requirement of the Rawlsian silence is being challenged, not just by conservative critics but even by such a staunch defender of conventional liberalism as Jürgen Habermas. Second, if Habermas and the other critics are right, then a fortiori, the public university—perhaps the most representative and exemplary of all the institutions of civil society—ought to welcome the infusion of relevant but closely held beliefs, including religious ones, in carrying out its research and teaching responsibilities. (shrink)

Alice Crary claims that “the standard view of the bearing of Wittgenstein's philosophy on ethics” is dominated by “inviolability interpretations”, which often underlie conservative readings of Wittgenstein. Crary says that such interpretations are “especially marked in connection with On Certainty”, where Wittgenstein is represented as holding that “our linguistic practices are immune to rational criticism, or inviolable”. Crary's own conception of the bearing of Wittgenstein's philosophy on ethics, which I call the “intrinsically-ethical reading”, derives from the influential New Wittgenstein school (...) of exegesis, and is also espoused by James Edwards, Cora Diamond, and Stephen Mulhall. To my eyes, intrinsically-ethical readings present a peculiar picture of ethics, which I endeavour to expose in Part I of the paper. In Part II I present a reading of On Certainty that Crary would call an “inviolability interpretation”, defend it against New Wittgensteinian critiques, and show that this kind of reading has nothing to do with ethical or political conservatism. I go on to show how Wittgenstein's observations on the manner in which we can neither question nor affirm certain states of affairs that are fundamental to our epistemic practices can be fruitfully extended to ethics. Doing so sheds light on the phenomenon that I call “basic moral certainty”, which constitutes the foundation of our ethical practices, and the scaffolding or framework of moral perception, inquiry, and judgement. The nature and significance of basic moral certainty will be illustrated through consideration of the strangeness of philosophers' attempts at explaining the wrongness of killing. (shrink)

This article examines four related aspects of Hegel's approach to the teaching of philosophy and to the philosophy of the teacher. Specifically, it highlights some of the views Hegel expressed on education in general whilst Rector of the Nuremberg gymnasium; describes his opinions on the place of philosophy within the school curriculum and the structure of the philosophy course which he designed for his pupils; examines the pedagogy which he employed in teaching his system of philosophy; and offers preliminary comments (...) on his insights into the contradictions which resist the abstract identity of the teacher. (shrink)

Spectres of False Divinity presents a historical and critical interpretation of Hume's rejection of the existence of a deity with moral attributes. In Hume's view, no first cause or designer responsible for the ordered universe could possibly have moral attributes; nor could the existence of such a being have any real implications for human practice or conduct. Hume's case for this 'moral atheism' is a central plank of both his naturalistic agenda in metaphysics and his secularizing program in moral theory. (...) It complements his wider critique of traditional theism, and threatens to rule out any religion that would make claims on moral practice. Thomas Holden situates Hume's commitment to moral atheism in its historical and philosophical context, offers a systematic interpretation of his case for divine amorality, and shows how Hume can endorse moral atheism while maintaining his skeptical attitude toward traditional forms of cosmological and theological speculation. (shrink)

This chapter contains sections titled: I II III.

Dating back to the very beginning of our knowledge of the events that constituted the Holocaust, some historians, social scientists, philosophers, theologians and public intellectuals argue that it was a unique historical, or even trans-historical, event. The aim of this article is to clarify what the uniqueness question should be about and to ascertain whether there are good reasons for judging that the Holocaust is unique. It examines the core meanings of ‘unique’ that feature in the literature and identifies which (...) of these is most apt for considering the possible uniqueness of the Holocaust. It then works out what it would take for the Holocaust to be unique in the appropriately rigorous sense, which is facilitated by inquiring into the nature of genocide. The key question turns on the relation of the Holocaust to genocide: was the Holocaust more than, or different from, genocide? (shrink)

To understand Hobbes’s handling of Christian scripture in Part 3 of Leviathan we need to see it in the light of his own radical account of the norms controlling public religious speech and practice as set out in Part 2 and in other works such as De Cive and De Corpore. As these texts make clear, Hobbes holds that we ought rationally to venerate the first cause of all, and that the proper way to venerate this awesome and incomprehensible being (...) is to publicly adopt the local culture’s religious practices, however arbitrary or conventional those practices might be. For the seventeenth-century English subject, the Anglo-Protestant scriptural religion provides the appropriate vehicle to express this rationally mandated religious piety, and thus provides a form of devotion that Hobbes embraces in a spirit of genuine religious reverence. At the same time, he also regards this religion, like all scriptural religions, as a conventional human artifact that, given the ear of the sovereign, he might hope to shape in favor of Hobbesian ideals such as civil obedience, the separation of philosophy from religion, and the extirpation of belief in an immaterial spirit-world. The proposed interpretation dissolves systematic problems facing irreligious readings on the one hand, and more straightforwardly Christian readings on the other. (shrink)

: Pierre Bayle is the most forthright and systematic early modern proponent of the actual parts doctrine, the period's counterpart to the 'doctrine of arbitrary undetached parts' familiar from current analytic mereology and metaphysics. In this paper I introduce both the actual parts account of the internal structure of matter and the rival system of potential parts. I then identify Bayle as the leading advocate of the actual parts doctrine and examine his arguments for this account.

Hume contrasts two different ways in which we might speak about the attributes of the first cause of all: first, in an attempt to describe the actual nature of this ultimate being or principle; or second, in ascribing attributes to it as so many honorifics, with no intention to describe but merely to express our own reverence. I survey Hume’s skeptical critique of the former, descriptive kind of talk, and also examine his purposes in considering and, through his character Philo, (...) apparently valorizing the latter, reverence-expressing kind of religious speech. (shrink)

Roger Gottlieb's Morality and the Environmental Crisis is a philosophical overview of the choices that will shape our grandchildren's lives, as dramatized in his speculative sketch of two very different futures at the end of this book. Gottlieb more than once notes that he is in his seventh decade of life, appropriately designating this work as that of an elder passing on the knowledge derived from his long career as a scholar, teacher, activist linking environmentalist with spiritual communities, and the (...) father of a daughter with special needs. First on his list of potential actions for addressing the environmental crisis is writing a book such as this to encourage readers to share his conviction of the need for... (shrink)

In this paper, I challenge the work of David Abram, who makes a case for phenomenology as the only philosophical tradition amenable to restoring balanced human-nature relationships. While phenomenology provides a useful conceptual framework for understanding the environmental ethics of oral cultures, this paper considers the tradition of American pragmatism to be more applicable to theenvironmental task at hand: devising an environmental ethic of reform for modern, capitalist, Western culture. The application of phenomenology and pragmatism to environmental ethics is compared (...) according to four main philosophical questions: the essential uncertainty of life, the existence of a human/nature divide, the necessary conditions for claiming truth, and the relative role of metaphysics or imagination and that of science in relating to the world. (shrink)

This dissertation is a historical and critical study of a controversy that raged among all the great figures of Enlightenment natural philosophy. The issue at stake is the structure or internal architecture of matter. One the one hand, an array of a priori arguments seems to show that matter must be fundamentally discrete in its fine structure: it must resolve to metaphysical atoms or monads. On the other hand, an opposing battery of a priori arguments seems to show that it (...) must be fundamentally continuous and altogether without simple first elements. ;The conflict between these rival sets of arguments deeply unsettled natural philosophers of the Enlightenment. Since both incompatible sets of arguments seemed compelling, the clash between them appeared to expose a paradox or antinomy in the new world view pioneered by Galileo and Newton. The new science's account of a fundamentally geometrical Creation, mathematicizable and intelligible to the human inquirer, seemed to be under threat. ;In this dissertation I present a rational reconstruction of the Enlightenment debate that challenges the standard interpretation in the secondary literature. Contra that standard interpretation, I argue that the debate turns crucially on substantive metaphysical theses about the 'filling' or 'stuffing' of matter, not just on theses about its mathematically tractable form or structure. The early moderns were committed to a particular metaphysical doctrine concerning the stuffing of matter and it is this doctrine that lies behind the paradoxes of material composition. Having set out this new metaphysical reading of the Enlightenment debate, I then mobilize it in order to reassess the various early modern responses to the paradoxes of material structure. (shrink)

For every Christian, The Comprehensive Guide to Apologetics delivers well-reasoned answers to complex theological issues, preparing believers to testify for their faith with confidence, intention, and Christlike wisdom.

Hegel und Foucault, in der Forschung meist als Antipoden dargestellt, stellen beide die Frage nach der Geschichtlichkeit des Wissens. Die Studie erarbeitet diese These anhand eines Vergleichs der Phänomenologie des Geistes mit der Archäologie des Wissens. Es wird dargelegt, inwiefern beide Konzeptionen kritisch auf Kants Vernunftkritik bezogen sind und in welchen Hinsichten sich ihre Theorien der Wissensentwicklung annähern.

This essay argues that Antony and Cleopatra’s pitting of Egypt against Rome is a cipher of aesthetic resistance to modern rationality. The coordinates are Adornian. Antony’s and Cleopatra’s complex identities elude the disenchanting, nominalist machinery in which diffuse indeterminacy necessitates conceptual imposition. Here, the individuals are essentially dramatized: sensate, embodied selves composed and expressed in relations of passionate recognition. The lovers’ deaths, and especially Cleopatra’s self-conscious theatre, rewrite the ascetic, dominative, and pseudo-theatrical rationality of Octavian Rome. The protest, the passion (...) and singularity, lives mainly through its expressive emphases – such as hyperbole – and the re-functioning of the very dominative roles and norms being opposed. This reflects the restricted but critical – aesthetic – status of early modern drama, and specifies its opposition to the deepening attack on sensate knowing in its world. (shrink)

One of the most significant philosophical voices of the twentieth century - the philosopher of 'the Other' - Emmanuel Levinas' work offers a challenge to the discipline of anthropology that claims knowledge of the human. Levinasian philosophy considers subjectivity and identity as 'secret'. For him an attempt to document humanity should then be placed in an ethics of ignorance and 'not-knowing' so that 'otherness' can be inspired. Anthropology thus reaches the Levinasian challenge of defining itself as a humanistic science as (...) well as a humanistic documentation of social life. This book endeavours to take Levinasian and anthropological precepts equally seriously and offers tentative conclusions. (shrink)

As the 20th century began, few effective therapies existed. This soon changed with major therapeutic discoveries turning the century into what has been called the golden age of therapeutics.1 The emphasis of most of these developments was on medicines for common disorders as they presented the greatest need. However, it also allowed pharmaceutical manufacturers to produce blockbuster drugs that provided a large return on investment. Rare disorders were overlooked because most are genetic in origin and scientific knowledge was lacking, making (...) it difficult to find treatments. The first genetic disorder with a therapy was phenylketonuria. The biochemist who proposed the first successful treatment in the 1950s was actively discouraged as phenylketonuria was genetic and ‘incurable’.2 Another reason was an absence of incentives to invest in developing medicines for which the return was limited, given the small numbers of potential patients. This changed from 1983 as several countries began introducing orphan drug policies, with Canada being a notable exception. As the millennium changed, some drugs for rare disorders were available, but the sequencing of the human genome in the early 2000s provided scientific knowledge to develop many more. The new therapies are often costly because they require millions, even billions, of dollars and years to develop, test and satisfy regulatory standards. …. (shrink)