A longstanding philosophical premise perceives simplicity as a desirable attribute of scientific theories. One of several raised justifications for this notion is that simple theories are more likely to indicate the true makeup of natural systems. Qualitatively parsimonious hypotheses and theories keep to a minimum the number of different postulated entities within a system. Formulation of such ontologically simple working hypotheses proved to be useful in the experimental probing of narrowly defined bio systems. It is less certain, however, whether qualitatively (...) parsimonious theories are effective indicators of the true nature of complex biological systems. This paper assesses the success of ontologically simple theories in envisaging the makeup of three complex systems in bacteriology, immunology, and molecular biology. Evidence shows that parsimonious theories completely misconstrued the actual ontologically complex constitutions of the three examined systems. Since evolution and selective pressures typically produce ontologically intricate rather than simple bio systems, qualitatively parsimonious theories are mostly inapt indicators of the true nature of complex biological systems. (shrink)

Ontology, since Aristotle, has been conceived as a sort of highly general physics, a science of the types of entities in reality, of the objects, properties, categories and relations which make up the world. At the same time ontology has been for some two thousand years a speculative enterprise. It has rested methodologically on introspection and on the construction and analysis of elaborate world-models and of abstract formal-ontological theories. In the work of Quine and others this ontological theorizing (...) in abstract fashion about the world was supplemented by the study, based on the use of logical methods, of the ontological commitments or presuppositions embodied in scientific theories. In recent years both types of ontological study have found application in the world of information systems, for example in the construction of frameworks for knowledge representation and in database design and translation. As ontology is in this way drawn closer to the domain of real-world applications, the question arises as to whether it is possible to use empirical methods in studying ontological theories. More specifically: can we use empirical methods to test the ontological theories embodied in human cognition? We set forth the outlines of a framework for the formulation and testing of such theories as they relate to the specific domain of geographic objects and categories. (shrink)

This article explores the role of sustainable living experiments as devices of public engagement. It engages with object-centred perspectives in the sociology of science and technology, which have characterized public experiments as sites for the domestication of technology, and as effective instruments of public involvement, because, in part, of the seductive force of their use of empirical forms of display. Green living experiments, which are conducted in the intimate setting of the home and reported on blogs, complicate this understanding, insofar (...) as they seek to format socio-material practices as sites of involvement. This has implications for how we conceive of the relations between public involvement and everyday material practices. While the latter are often located outside the public sphere, green living experiments extend the publicity genre of `being intimate in public' to things. It also follows that green living experiments do not so much solve but rather articulate problems of public involvement. (shrink)

Software testing is a complex and critical process for achieving product quality. Its importance has been increasing and well recognized, and there is a growing concern in improving the accomplishm...

The aim of this paper is to stress some ontological and methodological issues for Agent-Based Model (ABM) building, exploration, and evaluation in the Social and Human Sciences. Two particular domain of interest are to compare ABM and simulations (Model To Model) within a given academic field or across different disciplines and to use ontology for to discuss about the epistemic and methodological consequences of modeling choices. The paper starts with some definitions of ontology in philosophy and computer sciences. The (...) implicit and different ontology which underlies the approach of a same object of interest are discussed in the case of spatial economists and geographers. Finally, using the case of Shelling’s model, we discuss the concept of “ontological test,” and raise the question of the ontological compatibility between the “model world” and the “real world.”. (shrink)

The main interpretative claims in the chapter on Kant’s critique of the ontological argument in Ian Proops’s The Fiery Test of Critique are critically discussed.

Ontology cannot be left to the natural sciences, if only because it deals also with hypothetical and fictional objects. It pivots about proto-categorical issues relating to the features of objects of any and all kinds. This brings into its range issues that test the limits of knowledge by asking questions that are inherently unanswerable (for example: “What is an instance of an occurrence that no one ever mentions?”). And it raises issues of norms and values that science (in its (...) usual configuration) does not address. (shrink)

Agent-Based Models are useful to describe and understand social, economic and spatial systems' dynamics. But, beside the facilities which this methodology offers, evaluation and comparison of simulation models are sometimes problematic. A rigorous conceptual frame needs to be developed. This is in order to ensure the coherence in the chain linking at the one extreme the scientist's hypotheses about the modeled phenomenon and at the other the structure of rules in the computer program. This also systematizes the model design from (...) the thematician conceptual framework as well. The aim is to reflect upon the role that a well defined ontology, based on the crossing of the philosophical and the computer science insights, can play to solve such questions and help the model building. We analyze different conceptions of ontology, introduce the 'ontological test' and show its usefulness to compare models. Then we focus on the model building and show the place of a systematic ABM ontology. The latter process is situated within a larger framework called the 'knowledge framework' in which not only the ontologies but also the notions of theory, model and empirical data take place. At last the relation between emergence and ontology is discussed. (shrink)

For decades, physicians, philosophers, theologians, lawyers, and the public considered brain death a settled issue. However, a series of recent cases in which individuals were declared brain dead yet physiologically maintained for prolonged periods of time has challenged the status quo. This signals a need for deeper reflection and reexamination of the underlying philosophical, scientific, and clinical issues at stake in defining death. In this paper, I consider four levels of philosophical inquiry regarding death: the ontological basis, actual states (...) of affairs, epistemological standards, and clinical criteria for brain death. I outline several candidates for the states of affairs that may constitute death, arguing that we should strive for a single, unified ontological definition of death as a loss of integrated functioning as a unified organism, while acknowledging that two states of affairs may satisfy this concept. I argue that the clinical criteria for determining whole-brain death should be bolstered to meet the epistemic demand of sufficient certainty in defining death by adding indicators of cerebro-somatic dis-integration to the traditional triad of loss of consciousness, loss of brainstem function, and absence of confounding explanations. (shrink)

My article, “Whole-brain death and integration: Realigning the ontological concept with clinical diagnostic tests”.

The Protein Ontology provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation of experimentally known forms and annotations thereof is expected to expose discrepancies, differences, and gaps in our knowledge. We have annotated the early events of innate immune signaling mediated by Toll-Like Receptor 3 and 4 complexes in human, mouse, and chicken. The resulting ontology and annotation data set has (...) allowed us to identify species-specific gaps in experimental data and possible functional differences between species, and to employ inferred structural and functional relationships to suggest plausible resolutions of these discrepancies and gaps. (shrink)

The essay addresses the debates about the ontology of norms considering the case of accounting for customary norms. It undertakes and defends a stance in favor of a semantic ontology by developing a framework for the explanation of norms as abstract objects and their linking with social facts to be identified in categories like “customary”, “enacted”, “legal”, “grammatical”, and so on. Furthermore, the work addresses the rival conceptions (pragmatic and eclectic) by showing the specific impossibility that these face for giving (...) a satisfactory account on customary norms. The inquiry concludes by exploring some possible insights from the philosophy of mind to explain the conceptual nature of norms as mental representations. (shrink)

The objective of this research programme is to contribute to the establishment of the emerging science of Formal Ontology in Information Systems via a collaborative project involving researchers from a range of disciplines including philosophy, logic, computer science, linguistics, and the medical sciences. The re­searchers will work together on the construction of a unified formal ontology, which means: a general framework for the construction of ontological theories in specific domains. The framework will be constructed using the axiomatic-deductive method of (...) modern formal ontology. It will be tested via a series of applications relating to on-going work in Leipzig on medical taxonomies and data dictionaries in the context of clinical trials. This will lead to the production of a domain-specific ontology which is designed to serve as a basis for applications in the medical field. (shrink)

Philosophers of music often appeal to intuition to defend ontological theories of musical works. This practice is worrisome as it is rather unclear just how widely shared are the intuitions that philosophers appeal to. In this paper, I will first offer a brief overview of the debate over the ontology of musical works. I will argue that this debate is driven by a conflict between two seemingly plausible intuitions—the repeatability intuition and the creatability intuition—both of which may be defended (...) on the grounds that they are reflective of our actual musical practices. The problem facing philosophers within this debate is that there is no clear way to determine which of the two conflicting intuitions is more reflective of our musical practices. Finally, I offer discussion of an experimental study that was designed to test participants' intuitions regarding the repeatability of musical works. The evidence presented there suggests that the participants broadly accept the repeatability of musical works, but in a much narrower way than philosophers would likely accept. (shrink)

We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of neurological diseases and their associated signs and symptoms, assessments, diagnoses, and interventions that are encountered in the course of clinical practice. ND is built as an extension of the Ontology for General Medical Sciences — a high-level candidate OBO Foundry ontology that (...) provides a set of general classes that can be used to describe general aspects of medical science. ND is being built with classes utilizing both textual and axiomatized definitions that describe and formalize the relations between instances of other classes within the ontology itself as well as to external ontologies such as the Gene Ontology, Cell Ontology, Protein Ontology, and Chemical Entities of Biological Interest. In addition, references to similar or associated terms in external ontologies, vocabularies and terminologies are included when possible. Initial work on ND is focused on the areas of Alzheimer’s and other diseases associated with dementia, multiple sclerosis, and stroke and cerebrovascular disease. Extensions to additional groups of neurological diseases are planned. The second ontology, the Neuro-Psychological Testing Ontology (NPT), is intended to provide a set of classes for the annotation of neuropsychological testing data. The intention of this ontology is to allow for the integration of results from a variety of neuropsychological tests that assay similar measures of cognitive functioning. Neuro-psychological testing is an important component in developing the clinical picture used in the diagnosis of patients with a range of neurological diseases, such as Alzheimer’s disease and multiple sclerosis, and following stroke or traumatic brain injury. NPT is being developed as an extension to the Ontology for Biomedical Investigations. (shrink)

Primitive ontology is a program which seeks to make explicit the ontological commitments of physical theories in terms of a distribution of matter in ordinary space-time. This program targets wave-function realism, which interprets the high-dimensional configuration space on which wave-functions are defined as our fundamental physical space. Wave-function realism allegedly fails to account for a correspondence between the ontology it postulates and the ‘manifest image’ of the world in which experimental tests of the theory are performed, and therefore the (...) wave-function must be completed with an additional structure which describes what fundamentally exists in ordinary space-time: the ‘primitive ontology’. However primitive ontologies face some difficulties, in particular concerning the ontological status of the wave-function. In this paper, I defend a realist interpretation of the wave-function as describing objects in ordinary space-time, which does not require supplementing the theory with additional structure. The main difference between this proposal and other primitive ontology proposals is that the fundamental constituents of reality are not conceived of as localised objects, but as primitive relations. This interpretation purports to share the advantages of both wave-function realism and primitive ontologies without facing the same difficulties. I argue that the need for an additional structure stems from a commitment to the locality of the fundamental constituents of reality, and that such commitment is unnecessary for recovering the manifest image of the world. (shrink)

Contrary to Sankey’s central assumption, incommensurability does not imply incomparability of content, nor threaten scientific realism by challenging the rationality of theory comparison. Moreover, Sankey equivocates between reference to specific entities by statements used to test theories and reference to kinds by theories themselves. This distinction helps identify and characterize the genuine threat that incommensurability poses to realism, which is ontological discontinuity as evidenced in the historical record: Successive theories reclassify objects into mutually exclusive sets of kinds to (...) which they refer. That is why claiming that scientific progress is an increasingly better approximation to truth is difficult to justify. Similarly, Sankey’s attack on neo-Kantian antirealist positions is based on his misunderstanding of some of the central terms of those positions, making most of his attack on them ineffectual, including his diagnosis of their incoherence. We conclude by reiterating our conviction that in this debate meta-incommensurability plays an important role.Keywords: Scientific realism; Incommensurability; Meta-incommensurability; Thomas Kuhn; Paul Feyerabend; Howard Sankey. (shrink)

A pure significance test would check the agreement of a statistical model with the observed data even when no alternative model was available. The paper proposes the use of a modified p -value to make such a test. The model will be rejected if something surprising is observed. It is shown that the relation between this measure of surprise and the surprise indices of Weaver and Good is similar to the relationship between a p -value, a corresponding odds-ratio, (...) and a logit or log-odds statistic. The s -value is always larger than the corresponding p -value, and is not uniformly distributed. Difficulties with the whole approach are discussed. (shrink)

In recent times, informed consent has been adopted worldwide as a cornerstone to ensure autonomy during HIV testing. However, there are still ongoing debates on whether the edifice on which informed consent requirements are grounded, that is, personal autonomy, is philosophically, morally, and practically sound, especially in countries where HIV is an epidemic and/or may have a different ontological perspective or lived reality. This study explores the views of participants from Zambia. In-depth and focus group discussions were conducted at (...) various locations in Lusaka and Chongwe, Zambia. Participants came from various demographics, including people living with HIV, healthcare professionals and workers, policymakers, pregnant women, churchgoers, teachers, rural-based persons, and police officers. Data were manually analysed by conducting inductive and deductive thematic analyses. Results show that participants were not in favour of HIV policies that promote personal autonomy at the expense of pursuit of the common good. Participants viewed interdependence, not autonomy, as an essential characteristic of being human. The participants’ views have a realistic potential to provide a contextual and appropriate ethical, respectful, and realistic foundation for HIV testing policies. (shrink)

Following the growing economic relevance of mobile health (mHealth) and the increasing global prevalence of dementia, self-testing apps for dementia and mild neurocognitive disorder (MCD) have been developed and advertised. The apps’ promise of a quick and easy tool has been criticized in the literature from a variety of angles, but as we argue in this article, the celebratory characterization of self-testing also stands in disbalance to the various kinds of fears that may be connected to taking the test. (...) By drawing on Sara Ahmed’s phenomenological theory on emotions and by referring to illustrative experiences from two users with a particular dementia self-testing app, we explore four dimensions of fear derived from phenomenology: performative, ontological, embodied, and temporal dimensions. We argue that fear (1) motivates one to take the self-test and to try to take control over one’s health; (2) is shaped by and shapes the ways in which we make sense of ourselves and others as cognitively deficient; (3) constructs and is constructed by our differently embodied presence in the world; and that (4) testing makes a fearful future self as cognitively deficient more tangible. In outlining these different dimensions of fear, this article expands the understanding of the meaning of experiencing self-testing in comparison to the mostly quantitative literature on this topic. (shrink)

The Salivaomics Knowledge Base (SKB) is designed to serve as a computational infrastructure that can permit global exploration and utilization of data and information relevant to salivaomics. SKB is created by aligning (1) the saliva biomarker discovery and validation resources at UCLA with (2) the ontology resources developed by the OBO (Open Biomedical Ontologies) Foundry, including a new Saliva Ontology (SALO). We define the Saliva Ontology (SALO; http://www.skb.ucla.edu/SALO/) as a consensus-based controlled vocabulary of terms and relations dedicated to the salivaomics (...) domain and to saliva-related diagnostics following the principles of the OBO (Open Biomedical Ontologies) Foundry. The Saliva Ontology is an ongoing exploratory initiative. The ontology will be used to facilitate salivaomics data retrieval and integration across multiple fields of research together with data analysis and data mining. The ontology will be tested through its ability to serve the annotation ('tagging') of a representative corpus of salivaomics research literature that is to be incorporated into the SKB. Background Saliva (oral fluid) is an emerging biofluid for non-invasive diagnostics used in the detection of human diseases. The need to advance saliva research is strongly emphasized by the National Institute of Dental and Craniofacial Research (NIDCR), and is included in the NIDCR's 2004- 2009 expert panel long-term research agenda [1]. The ability to monitor health status, disease onset, progression, recurrence and treatment outcome through noninvasive means is highly important to advancing health care management. Saliva is a perfect medium to be explored for personalized individual medicine including diagnostics, offering a non-invasive, easy to obtain means for detecting and monitoring diseases. Saliva testing potentially allows the patient to collect their own saliva samples at home, yielding convenience for the patient and savings in health costs, and facilitating multiple sampling. Specimen collection is less objectionable to patients and easier in children and elderly individuals. Due to these advantages. (shrink)

This article examines how problems of validity in empirical social research differ from those in natural science. Specifically, we focus on how some ontological peculiarities of the object of study in social science bear on validity requirements. We consider these issues in experimental validity as well as in test validity because, while both fields hold large intellectual traditions, research tests or questionnaires are less closely connected to natural science methodology than experiments.

In The Practice of Political Theory, Clayton Chin puts Richard Rorty’s pragmatism in dialogue with a range of contemporary political theorists, particularly focusing on how his notion of cultural politics can speak to the ontological turn in political theory. This article focuses on Chin’s claim that Rorty’s cultural politics provides an ethos of inclusive and tolerant political engagement. After exploring the basis for Chin’s interpretation, it identifies three tensions in this ethos, in relation to character of its demandingness, the (...) fissure between ethnocentric and egalitarian engagement, and the relationship of this ethos to the virtues and procedures of democratic citizenship. (shrink)

The purpose of my study is to reconstruct the historical development of Kant's pre- critical approach to mechanical explanation and cosmology. I shall focus on three main works: the 1755 Theorie des Himmels, the 1763 Beweisgrund and the 1766 Träume. I shall challenge some interpretations of the relation between mechanism and finalism, looking for the emergence of a principle of demarcation separating both ontologically and epistemologically organics from inorganics products. I shall try to show why Kant came to be dissatisfied (...) with his early systematic account of the formation and arrangement of the heavenly bodies on purely mechanical principles. Finally I shall argue that the pre-critical period ends, paving the way to a revision of cosmology in the light of an appreciation of the role of chemical affinity for the construction of the world-edifice. (shrink)

This study investigates the ontological status of some physical and cosmological theories that are not based on empirical observation and probably cannot be tested empirically. It is suggested that these theories exist only in our consciousness and are no more than Kantian ideas. Indeed, these theories imply paradoxes as was predicted by Kant regarding ideas of pure reason.

We describe a prototype ontology-driven information system (ODIS) that exploits what we call Portion of Reality (POR) representations. The system takes both sensor data and natural language text as inputs and composes on this basis logically structured POR assertions. The goal of our prototype is to represent both natural language and sensor data within a single framework that is able to support both axiomatic reasoning and computation. In addition, the framework should be capable of discovering and representing new kinds of (...) situations and thematic roles, (e.g., roles such as agent, patient and instrument), based on new compositions of existing representations. We applied our prototype in an intelligence analysis use case to test the hypothesis that a framework of this sort can produce usefully structured information from combined natural language and sensor data inputs. We further tested our hypothesis by adding an enhanced US Air Force ontology framework to our ODIS in order to (1) process a collection of sensor data, intel reports, and mission plans; (2) build composite POR representations from these data; and (3) machine analyze the fused results to infer mission threats. (shrink)

In recent years, many philosophers have argued that it is inherently illiberal to make citizenship for migrants conditional on a test. On these arguments, liberalism itself demands either that no test be administered, or that the test be so easy as to serve merely a symbolic function. In this paper, I make two claims in response to these ideas. The first is that a citizenship test - even a difficult one - is not inherently illiberal, when (...) what is tested for reflects the actual backdrop of knowledge and history required for responsible participation in political discourse. The second is that we have reason to be suspicious of any existing citizenship test, but for reasons of prudence, rather than liberal principle. Existing political elites can be relied upon to make citizenship tests reflect not what is actually required for political agency, but what those elites would like to see reinforced and rein scribed as part of the national identity. Thus, we are right to be wary of citizenship tests - not because liberalism condemns them, but because of predictable moral failures on the part of those charged with writing such tests. (shrink)

Cognitive categories in the geographic realm appear to manifest certain special features as contrasted with categories for objects at surveyable scales. We have argued that these features reflect specific ontological characteristics of geographic objects. This paper presents hypotheses as to the nature of the features mentioned, reviews previous empirical work on geographic categories, and presents the results of pilot experiments that used English-speaking subjects to test our hypotheses. Our experiments show geographic categories to be similar to their non-geographic (...) counterparts in the ways in which they generate instances of different relative frequencies at different levels. Other tests, however, provide preliminary evidence for the existence of important differences in subjects’ categorizations of geographic and non-geographic objects, and suggest further experimental work especially with regard to the role in cognitive categorization of different types of object-boundaries at different scales. (shrink)

Moral and social philosophers often assume that humans beings are and ought to be autonomous. This tradition of individualism, or atomism, underlies many of our assumptions about ethics and law; it provides a legitimating framework for liberal democracy and free market capitalism. In this powerful book, David Weissman argues against atomistic ontologies, affirming instead that all of reality is social. Every particular is a system created by the reciprocal causal relations of its parts, he explains. Weissman formulates an original metaphysics (...) of nature that remains true to what is known through the empirical sciences, and he applies his hypothesis to a range of topics in psychology, morals, sociology, and politics. The author contends that systems are sometimes mutually independent, but many systems-human ones especially-are joined in higher order systems, such as families, friendships, businesses, and states, that are overlapping or nested. Weissman tests this schematic claim with empirical examples in chapters on persons, sociality, and value. He also considers how the scheme applies to particular issues related to deliberation, free speech, conflict, and ecology. (shrink)

Cognitive categories in the geographic realm appear to manifest certain special features as contrasted with categories for objects at surveyable scales. We have argued that these features reflect specific ontological characteristics of geographic objects. This paper presents hypotheses as to the nature of the features mentioned, reviews previous empirical work on geographic categories, and presents the results of pilot experiments that used English-speaking subjects to test our hypotheses. Our experiments show geographic categories to be similar to their non-geographic (...) counterparts in the ways in which they generate instances of different relative frequencies at different levels. Other tests, however, provide preliminary evidence for the existence of important differences in subjects’ categorizations of geographic and non-geographic objects, and suggest further experimental work especially with regard to the role in cognitive categorization of different types of object-boundaries at different scales. (shrink)

Since 2002 we have been testing and refining a methodology for ontology development that is now being used by multiple groups of researchers in different life science domains. Gary Merrill, in a recent paper in this journal, describes some of the reasons why this methodology has been found attractive by researchers in the biological and biomedical sciences. At the same time he assails the methodology on philosophical grounds, focusing specifically on our recommendation that ontologies developed for scientific purposes should be (...) constructed in such a way that their terms are seen as referring to what we call universals or types in reality. As we show, Merrill’s critique is of little relevance to the success of our realist project, since it not only reveals no actual errors in our work but also criticizes views on universals that we do not in fact hold. However, it nonetheless provides us with a valuable opportunity to clarify the realist methodology, and to show how some of its principles are being applied, especially within the framework of the OBO (Open Biomedical Ontologies) Foundry initiative. (shrink)

Sustainability in systems refers to applying sustainable principles and practices to create more resilient, efficient, and equitable systems that promote the well-being of people and the planet. Sustainability is an essential topic in contemporary software engineering, and its relationship with the characteristics and properties of a system or product called quality attributes is still an open question since each researcher has established their definition of sustainability in software. This has created diverse terms and concepts for distinct application environments and scopes, (...) creating ambiguity and misconceptions. This work defines a domain ontology of Sustainability in Software named SinSO to address these issues. SinSO was implemented in OWL, using competency-based questions to validate. The findings show that this proposal satisfies several quality and content requirements. Also, using Protégé and the Hermit reasoner, we verified that SinSO is consistent since the ontology statements are coherent and do not lead to conflicting or contradictory conclusions. In addition, competency questions allowed us to demonstrate that SinSO does fulfill its purpose. FOCA methodology allowed us to evaluate SinSO quality. Also, SinSO was used in two case studies, one about software for senior-citizen smart-home, and the other, a simulator to develop and test smart-city applications, achieving positive outcomes. To verify its accuracy, completeness, and maintainability, further evaluations of SinSO are needed in real case studies. We conclude that SinSO can significantly contribute to reducing ambiguity and enhancing comprehension in this area. Furthermore, SinSO can be an effective tool for engineers to recognize the concepts and relationships in the sustainable domain to consider in the systems development life cycle to build sustainable systems. (shrink)

In order for theology to have a cognitive dimension, it is necessary to have procedures for testing and critically evaluating theological models. We make use of certain features of scientific models to show how science has been able to move beyond the poles of foundationalism, represented by logical positivism, and antifoundationalism or relativism, represented by the sociologists of knowledge. These ideas are generalized to show that constructing and testing theological models similarly offers a means by which theology can move beyond (...) confessionalism and postmodernism. Our starting point is Paul Tillich's concept of God as the ground of being and the different levels of consciousness and thinking that accompany his understanding of theology. The ontological argument of Anselm is shown to play a key role, not as a proof for the existence of God but as a means for testing theological models. An example of a theological model, drawn from the domain of philosophy of science, is presented to show how theological models are constructed and tested. (shrink)

The central premise of this book is that biblical Hebrew narrative, in terms of its structure, tends to operate under similar mechanical constraints to those of a stage-play; wherein space is central, characters are fluid, and objects within the narrative tend to take on a deep internal significance. The smaller episodic narrative units within the Hebrew aesthetic tend to grant primacy to space, both ideologically and at the mechanical level of the text itself. However space, as a determinate structural category, (...) has been all but overlooked in the field of biblical studies to date; reflecting perhaps our own inability, as modern readers, to see beyond the dominant cinematic aesthetic of our times. The book is divided into two major sections, each beginning with a more theoretical approach to the function of narrative space, and ending with a practical application of the previous discussion; using Genesis 28:10-22 (the Bethel narrative) and the book of Ruth respectively, as test cases.Where does the notion of free will come from? How and when did it develop, and what did that development involve? In Michael Frede's radically new account of the history of this idea, the notion of a free will emerged from powerful assumptions about the relation between divine providence, correctness of individual choice, and self-enslavement due to incorrect choice. Anchoring his discussion in Stoicism, Frede begins with Aristotle--who, he argues, had no notion of a free will--and ends with Augustine. Frede shows that Augustine, far from originating the idea (as is often claimed), derived most of his thinking about it from the Stoicism developed by Epictetus. (shrink)

In this paper I address three problems posed by modern medical technology regarding comatose dying patients. The first is that physicians sometimes hide behind the tests for whole-brain death rather than make the necessary human decision. The second is that the tests themselves betray a metaphysical judgment about death that may be ontologically faulty. The third is that discretion used by physicians and patients and/or family in deciding to cease treatment when the whole-brain death criteria may not be met are (...) sometimes open to challenge. In each of these problems I find that the operative concept of death relates to life itself. This point is expanded by examining the uses of the word death in our language and culture. From these I formulate an initial ontology of death. In it, death is described through a relationship with life, rather than as an absence of life, of consciousness, awareness, or sensation. This ontology then leads to a proposal for an ethics of discretion about the discontinuation of treatment for comatose patients. (shrink)

Statistics play a critical role in biological and clinical research. However, most reports of scientific results in the published literature make it difficult for the reader to reproduce the statistical analyses performed in achieving those results because they provide inadequate documentation of the statistical tests and algorithms applied. The Ontology of Biological and Clinical Statistics (OBCS) is put forward here as a step towards solving this problem. Terms in OBCS, including ‘data collection’, ‘data transformation in statistics’, ‘data visualization’, ‘statistical data (...) analysis’, and ‘drawing a conclusion based on data’, cover the major types of statistical processes used in basic biological research and clinical outcome studies. OBCS is aligned with the Basic Formal Ontology (BFO) and extends the Ontology of Biomedical Investigations (OBI), an OBO (Open Biological and Biomedical Ontologies) Foundry ontology supported by over 20 research communities. We discuss two examples illustrating how the ontology is being applied. In the first (biological) use case, we describe how OBCS was applied to represent the high throughput microarray data analysis of immunological transcriptional profiles in human subjects vaccinated with an influenza vaccine. In the second (clinical outcomes) use case, we applied OBCS to represent the processing of electronic health care data to determine the associations between hospital staffing levels and patient mortality. Our case studies were designed to show how OBCS can be used for the consistent representation of statistical analysis pipelines under two different research paradigms. By representing statistics-related terms and their relations in a rigorous fashion, OBCS facilitates standard data analysis and integration, and supports reproducible biological and clinical research. (shrink)

We performed a qualitative analysis of the Thesaurus in order to assess its conformity with principles of good practice in terminology and ontology design. We used both the on-line browsable version of the Thesaurus and its OWL-representation (version 04.08b, released on August 2, 2004), measuring each in light of the requirements put forward in relevant ISO terminology standards and in light of ontological principles advanced in the recent literature. Version 04.08b of the NCI Thesaurus suffers from the same broad (...) range of problems that have been observed in other biomedical terminologies. For its further development, we recommend the use of a more principled approach that allows the Thesaurus to be tested not just for internal consistency but also for its degree of correspondence to that part of reality which it is designed to represent. (shrink)

According to recent suggestions within the global pragmatism discussion, metaethical debate must be fundamentally re-framed. Instead of carving out metaethical differences in representational terms, it has been argued that metaethics should be given an inferentialist footing. In this paper, I put inferentialist metaethics to the test by subjecting it to the following two criteria for success: Inferentialist metaethicists must be able to save the metaethical differences between moral realism and expressivism, and do so in a way that employs understandings (...) of these metaethical accounts which would be acceptable to moral realists or expressivists who endorse an inferentialist theory of meaning. Two results follow from my discussion. The first concerns inferentialist metaethics more narrowly, casting doubts on inferentialists’ ability to fulfil the two criteria for success by showing that proposed metaethical demarcation attempts either meet the first criterion but violate the second, or pass the second criterion but fail the first. The second upshot pertains to the global pragmatism debate more widely, pressing the point that inferentialists have not as yet provided a convincing account of ontological commitment. (shrink)

Could a person ever transcend what it is like to be in the world as a human being? Could we ever know what it is like to be other creatures? Questions about the overcoming of a human perspective are not uncommon in the history of philosophy. In the last century, those very interrogatives were notably raised by American philosopher Thomas Nagel in the context of philosophy of mind. In his 1974 essay What is it Like to Be a Bat?, Nagel (...) offered reflections on human subjectivity and its constraints. Nagel’s insights were elaborated before the social diffusion of computers and could not anticipate the cultural impact of technological artefacts capable of materializing interactive simulated worlds as well as disclosing virtual alternatives to the “self.” In this sense, this article proposes an understanding of computers as epistemological and ontological instruments. The embracing of a phenomenological standpoint entails that philosophical issues are engaged and understood from a fundamentally practical perspective. In terms of philosophical praxis, or “applied philosophy,” I explored the relationship between human phenomenologies and digital mediation through the design and the development of experimental video games. For instance, I have conceptualized the first-person action-adventure video game Haerfest (Technically Finished 2009) as a digital re-formulation of the questions posed in Nagel’s famous essay. Experiencing a bat’s perceptual equipment in Haerfest practically corroborates Nagel’s conclusions: there is no way for humans to map, reproduce, or even experience the consciousness of an actual bat. Although unverifiable in its correspondence to that of bats, Haerfest still grants access to experiences and perceptions that, albeit still inescapably within the boundaries of human kinds of phenomenologies, were inaccessible to humans prior to the advent of computers. Phenomenological alterations and virtual experiences disclosed by interactive digital media cannot take place without a shift in human kinds of ontologies, a shift which this study recognizes as the fundamental ground for the development of a new humanism (I deem it necessary to specify that I am not utilizing the term “humanism” in its common connotation, that is to say the one that emerged from the encounter between the Roman civilization and the late Hellenistic culture. According to this conventional acceptation, humanism indicates the realization of the human essence through “scholarship and training in good conduct” (Heidegger 1998, p. 244). However, Heidegger observed that this understanding of humanism does not truly cater to the original essence of human beings, but rather “is determined with regard to an already established interpretation of nature, history, world, and […] beings as a whole.” (Heidegger 1998, p. 245) The German thinker found this way of embracing humanism reductive: a by-product of Western metaphysics. As Heidegger himself specified in his 1949 essay Letter on Humanism, his opposition to the traditional acceptation of the term humanism does not advocate for the “inhuman” or a return to the “barbaric” but stems instead from the belief that the humanism can only be properly understood and restored in culture as more original way of meditating and caring for humanity and understanding its relationship with Being.). Additionally, this study explicitly proposes and exemplifies the use of interactive digital technology as a medium for testing, developing and disseminating philosophical notions, problems and hypotheses in ways which are alternative to the traditional textual one. Presented as virtual experiences, philosophical concepts can be accessed without the filter of subjective imagination. In a persistent, interactive, simulated environment, I claim that the crafting and the mediation of thought takes a novel, projective (In Martin Heidegger’s 1927 Being and Time, the term “projectivity” indicates the way a Being opens to the world in terms of its possibilities of being (Heidegger 1962, pp. 184–185, BT 145). Inspired by Heidegger’s and Vilem Flusser’s work in the field of philosophy of technology as well as Helmuth Plessner’s anthropological position presented in his 1928 book Die Stufen des Organischen und der Mensch. Einleitung in die philosophische Anthropologie, this study understands the concept of projectivity as the innate openness of human beings to construct themselves and their world by means of technical artefacts. In this sense, this study proposes a fundamental understanding of technology as the materialization of mankind’s tendency to overcome its physical, perceptual and communicative limitations.) dimension which I propose to call “augmented ontology.”. (shrink)

The call to re-envision theoretical psychology comes after more than a half century of theorists’ efforts to re-envision psychological science. Especially prominent is persistent critique of mainstream psychology’s deployment of the ontological and epistemic templates of the natural sciences, in theorists’ multifaceted mission to replace that metatheoretical grounding with one deemed properly suited to a thoroughgoing psychological science of lived experience. Despite anticipated objection, I call for consideration of boundary-pushing trends and challenges in the natural sciences, especially in theory (...) and philosophy of physics, with an eye toward inspiring theoretical psychologists and mainstream psychologists anew. I also draw attention to the use of relevant findings of mainstream psychological scientists by philosophers of psychology who ask traditional philosophical questions nonetheless. This use mirrors the use of relevant findings of biological scientists by philosophers of biology within the burgeoning field of biophilosophy, in which I find an apt analogue to what I herein call “psycphilosophy.” By adopting a more mutual, relational attitude toward disciplines that have heretofore been dismissed, theoretical psychologists may attain a better position from which to make more constructive and productive contact with mainstream psychological scientists—contact that may facilitate the impact on the mainstream that has to date eluded theorists. (shrink)

This paper aims to show that dominant conceptions of intelligence used in artificial intelligence (AI) are biased by normative assumptions that originate from the Global North, making it questionable if AI can be uncritically applied elsewhere without risking serious harm to vulnerable people. After the introduction in Sect. 1 we shortly present the history of IQ testing in Sect. 2, focusing on its multiple discriminatory biases. To determine how these biases came into existence, we define intelligence ontologically and underline its (...) constructed and culturally variable character. Turning to AI, specifically the Turing Test (TT), in Sect. 3, we critically examine its underlying intelligence conceptions. The test has been of central influence in AI research and remains an important point of orientation. We argue that both the test itself and how it is used in practice risk promoting a limited conception of intelligence which solely originated in the Global North. Hence, this conception should be critically assessed in relation to the different global contexts in which AI technologies are and will be used. In Sect. 4, we highlight how unequal power relations in AI research are a real threat, rather than just philosophical sophistry while considering the history of IQ testing and the TT’s practical biases. In the last section, we examine the limits of our account and identify fields for further investigation. Tracing colonial continuities in AI intelligence research, this paper points to a more diverse and historically aware approach to the design, development, and use of AI. (shrink)

Two opposing uses of the term ‘Scientific Ontology’ reflect attitudes towards the relation between science and philosophical ontology. On the one side we can try to understand the broader picture by looking at the empirical details. On the other side we can try to find overarching principles that explain our observations. I am deeply aware of the history of this subject but—as we all know—history repeats itself. Perhaps it is time now for, actually, deduction to take more place in science. (...) Perhaps—which of course is my own belief—we have reached the end of the road of so much depending on empirical observations. The natural sciences have reached beyond what is possible to empirically detect. My own research is an attempt to redefine our ontological starting point and to really test if the world only is physical. In this Reply I put Tambassi’s reply in the explicit context of my definition of scientific ontology. The outcome is that scientific ontology cannot settle the debate in the geographical sciences as to whether the geographical world is mind-dependent or not, but that the geographical universe, in that case, as a universe, belongs to the domain of scientific ontology. (shrink)

The ontology of Ortega y Gasset crystallized slowly between the years of 1934 and 1945. These were years of exile, years of war and financial insecurity that forced him to move from country to country. His health too was sorely tested on various occasions during this period. Remoteness from intellectual resources, familiar libraries, co-laborers, were doubtlessly disturbing obstacles to his progress. Ortega was fifty in 1933; yet for all these hindrances the next decade of his life was his most ambitiously (...) productive. (shrink)

We discuss recent progress in the development of cognitive ontologies and summarize three challenges in the coordinated development and application of these resources. Challenge 1 is to adopt a standardized definition for cognitive processes. We describe three possibilities and recommend one that is consistent with the standard view in cognitive and biomedical sciences. Challenge 2 is harmonization. Gaps and conflicts in representation must be resolved so that these resources can be combined for mark-up and interpretation of multi-modal data. Finally, Challenge (...) 3 is to test the utility of these resources for large-scale annotation of data, search and query, and knowledge discovery and integration. As term definitions are tested and revised, harmonization should enable coordinated updates across ontologies. However, the true test of these definitions will be in their community-wide adoption which will test whether they support valid inferences about psychological and neuroscientific data. (shrink)

Many Global North contexts are experiencing conflict in feminist discourses between supporters of trans and gender diverse self-identification and self-proclaimed ‘gender critical’ feminists who consider this to undermine feminist goals. We argue that the channelling of contemporary feminist discourse into defensive and oppositional channels has foreclosed the space for more nuanced and future-oriented, utopian thought around freedom from sex/gender, limiting the prospect of developing a coalition of actors focused not on difference, but rather on commonality. Putting classic feminist works by (...) Simone de Beauvoir, Shulamith Firestone and Luce Irigaray into dialogue, we consider an alternative approach to freedom premised on an ontology of potentiality combined with acceptance of the materiality of the binary gender hierarchy, that nonetheless remains utopian and open-ended, demonstrating the capacity to transcend these impasses and potentially overcome these divides. (shrink)

We provide a methodology for the creation of ontological partitions in biomedicine and we test the methodology via an application to the phenomenon of blood pressure. An ontology of blood pressure must do justice to the complex networks of intersecting pathways in the organism by which blood pressure is regulated. To this end it must deal not only with the anatomical structures and physiological processes involved in such regulation but also with the relations between these at different levels (...) of granularity. For this purpose our ontology offers a variety of distinct partitions � of substances, processes and functions � and integrates these together within a single framework via transitive networks of part-whole and dependence relations among the entities in each of these categories. The paper concludes with a comparison of this methodology with the approaches of GOTM, KEGG, DIP and BIND and provides an outline of how the methodology is currently being applied in the field of biomedical database integration. (shrink)

The inherent normativity of HTA can be conceptualized as a result of normative commitments, a concept that we further specify to encompass moral, epistemological and ontological commitments at play in the practice of HTA. Based on examples from literature, and an analysis of the example of assessing Non-Invasive Prenatal Testing (NIPT), we will show that inevitable normative decisions in conducting an assessment commits the HTA practitioner to moral (regarding what makes a health technology desirable), ontological (regarding which effects (...) of health technology are conceivable), and epistemological (regarding how to obtain reliable information about health technology) norms. This highlights and supports the need for integrating normative analysis and stakeholder participation, providing guidance to HTA practitioners when making normative choices. This will foster a shared understanding between those who conduct, use, or are impacted by assessments regarding what are conceivable and desirable outcomes of using health technology, and how to collect reliable information to assess whether these outcomes are (going to be) realized. It also provides more insight into the implications of different normative choices. (shrink)