The nuclear pore complex (NPC) is emerging as a center for recruitment of a class of “difficult to repair” lesions such as double‐strand breaks without a repair template and eroded telomeres in telomerase‐deficient cells. In addition to such pathological situations, a recent study by Su and colleagues shows that also physiological threats to genome integrity such as DNA secondary structure‐forming triplet repeat sequences relocalize to the NPC during DNA replication. Mutants that fail to reposition the triplet repeat locus to the (...) NPC cause repeat instability. Here, we review the types of DNA lesions that relocalize to the NPC, the putative mechanisms of relocalization, and the types of recombinational repair that are stimulated by the NPC, and present a model for NPC‐facilitated repair. (shrink)

The aim of this paper is to offer a Henrian interpretation of the debate between Sartre and Merleau-Ponty concerning the place of the imaginary in the perceptive life. The hypothesis is that in Sartre, Merleau-Ponty and Henry, the role of the imaginary in the original affective experience which the perceptive life has of its own intrinsic vulnerability can be investigated on three levels: the articulation between the absolute dimension and the egological dimension of consciousness in Sartre, the genesis of perception (...) in the body in Merleau-Ponty, and the immanent adherence of the perceptive act to the radical suffering of its own force in Henry. From each of these three levels, the paper shows that without an imaginary in charge of bringing it back constantly to the experience of its own original vulnerability, the perceptive life is bound to lose the aff ective density of its relation to the perceived, and therefore is bound to become disincarnate. (shrink)

L?objectif de cet article est de montrer à partir d?une libre reprise de certaines thèses développées par le second Merleau-Ponty qu?un certain usage de la perception est susceptible d?accroître l?épreuve que le sujet fait d?être profondément requis par le sens d?une situation qu?il est en train de vivre. Notre hypothèse est qu?il est nécessaire pour ce faire que l?acte perceptif s?éprouve intrinsèquement mis en jeu par la situation à laquelle il se rapporte, mis en jeu dans l?épreuve affective qu?il fait (...) de sa possibilité originaire. Ce n?est donc pas seulement ce qui est perçu qui est susceptible de faire événement dans la vie du sujet, mais la façon dont l?acte perceptif est amené à se déployer et à éprouver sa propre possibilité au contact du perçu. Il importe en ce sens de faire une distinction entre les propriétés affectives conférées intentionnellement au perçu et l?épreuve affective que l?acte per­ceptif fait de lui-même en se rapportant à celui-ci. Nous allons ainsi défendre l?idée selon laquelle l?acte perceptif ne peut participer en profondeur à l?épreuve d?une situation qui fait événement dans la vie du sujet que s?il se laisse être profondément mis en jeu par cette situation. Au départ de cette réflexion, il importe ainsi de reconnaître que le sujet peut être ébranlé par le contenu de telle ou telle situation sans que son acte perceptif se laisse pour autant mettre. (shrink)

L’objectif de cet article est de montrer que la phénoménologie de Michel Henry offre des ressources importantes pour interroger le rôle de la vie sociale et du langage dans l’épreuve que les individus font tout autant de la puissance que de la vulnérabilité intrinsèque de leur désir d’éprouver la vie.

Table des matières 1. Émotion et situation 2. La performativité de l?émotion 3. Émotion et action 4. L?imaginaire et la facticité du réel 5. La théâtralité originaire de l?agir 6. Jeu et incarnation 7. Croyance, sens, imaginaire 8. La performativité de l?image 9. Le corps de l?image, l?image du corps 10. L?imaginaire et l?épaisseur de la vie 11. La théâtralisation de l?émotion 12. Émotion et influence sociale 13. Conclusion.

L’objectif de cette contribution est de montrer de quelle façon la phénoménologie de Renaud Barbaras permet de faire droit à ce que l’on peut définir comme la finitude radicale de la manifestation. Si, chez Barbaras, la finitude constitutive de toute manifestation est radicale, c’est dans la mesure où elle est elle-même finie, c’est-à-dire habitée par une indétermination originaire. L’inachèvement constitutif de toute manifestation est lui-même inachevé. Il y a un polymorphisme de la finitude...

L’objectif de cet article est de construire à partir d’une reprise de certaines thèses de Michel Henry les premiers jalons d’une phénoménologie radicale du soin. Sur base d’une interrogation sur le rapport entre le souffrir originaire de la vie et son mouvement immanent d’ipséisation, l’auteur montre qu’en refusant toute forme de naturalisation du consentement du pâtir de la vie à lui-même, la phénoménologie radicale de Michel Henry permet de développer une nouvelle approche du soin, notamment du point de vue de (...) son rapport à la dimension originairement intersubjective du désir de s’éprouver de la vie. L’article se termine par une réflexion sur la dimension potentialisante d’un certain usage des rôles dans le rapport de l’acte médical à la singularité radicale de l’individu souffrant. Dans la perspective d’une phénoménologie radicale de la vie, l’acte médical ne peut pas être seulement décrit comme reposant sur l’adhésion des individus à la vie. Il est plus profondément encore amené à accroître par sa façon même de s’effectuer l’adhésion intérieure des individus au pâtir radical de leur vie. (shrink)

Diyanet İşleri Başkanlığı 2013-2014 eğitim yılıyla birlikte kendine yeni bir hizmet alanı açmış ve Cumhuriyet tarihinde ilk olarak resmi okul öncesi din eğitimini 4-6 yaş Kur’an Kursları ile başlatmıştır. Bu alanda her geçen yıl tecrübe kazanılmış olsa da çeşitli noktalarda bazı sorunların devam ettiği görülmektedir. Araştırmanın konusu 4-6 yaş Kur’an Kursları etkinlik kitaplarında yer alan hikâyelerin içerik ve resimlendirme bakımından okul öncesi çağındaki çocuklar için uygunluğunun incelenmesidir. Araştırmamızın amacı, okul öncesi dönemde okuma yazma bilmeyen çocuklar için hikâyelerin ve özellikle de (...) hikâyelerde yer alan resimlerin ve görsellerin öğrenmede çok önemli bir paya sahip olduğunun altını çizerek etkinlik ve ders kitaplarının düzenlenmesine ve zenginleştirilmesine katkı sağlamaktır. Nitel bir araştırma olan çalışmada mevcut etkinlik kitapları incelenmiştir. Araştırma, var olan durumu, var olduğu şekilde betimlemeyi amaçlayan tarama modelidir ve etkinlik kitaplarındaki hikâyeler ve resimler betimsel analiz yoluyla incelenmiştir. Ulaşılan sonuçlara göre; 4-6 yaş Kur’an Kurslarındaki etkinlik kitaplarındaki hikâyelerin içeriklerinin okul öncesi çocukların seviyesine göre, bilgilendirme işlevini gören ancak etkileme ve çocukta merak uyandırma noktasında yetersiz olduğu, resimlerinin ise bazı hikâyelerde metne uygun olmadığı ve çocuğun hayal dünyasına hitap etmediği tespit edilmiştir. Bu konuda daha hareketli ve renkli resimlerle hazırlanmış ders ve etkinlik kitaplarının gerekliliği ortaya konmuş ve önerilerde bulunulmuştur. The Presidency of Religious Affairs initiated a new service area in the 2013-2014 Academic Year. The Presidency, which previously provided educational activities for young and middle-aged groups and primary school children during summer courses, started official preschool religious education for the 4-6 year-old age group in Quran Courses for the first time in 2013-2014. Although the experience has been acquired in this field with each passing year, some problems are still noticeable at various points. The present study examines the contents and aesthetic aspects of the stories included in Quran Courses activity books for 4-6 year-old children. The purpose of the study is to underline that stories and especially the illustrations and visuals in stories, have very important roles in learning for children who are illiterate in the preschool period, and the study aims to contribute to the organization and enrichment of the activities and textbooks by drawing attention to this field. In this study, which has a qualitative design, the existing activity books are examined. The study also has a screening model, which aims to explain the present situation in the way it is. The stories and illustrations in the activity books were examined in this study via descriptive analysis based on the criteria that should exist in children’s literature books. In this respect, we tried to summarize and interpret the data obtained in the study according to the pre-determined criteria. This study, which draws attention to the importance of books with illustrations, which have an important function in the development of preschool children, and their effects on children, examined the contents of the stories and the pictures used in the narration of the stories in the activity books used in the Qur'an Courses for 4-6 year-old children. Before making an assessment on the subject, the author tried to find an answer to the question of what stories and pictures mean for preschool children and what is the function and importance of pictures and stories in their education. According to the criteria, the author examined and evaluated nine stories in the activity books prepared for the Qur'an Courses for the ages of 4-6, in which especially pictures are used in the narration. (shrink)

El artículo argumenta que los niños y niñas tienen la palabra porque así lo demuestra el proceso de socialización primaria “saludable” y, por otra parte, porqué existen Declaraciones y Cartas de Derechos que lo avalan. No obstante, el artículo concluye que para que la palabra entre en la escuela es necesario cambiar su “arquitectura”, cultura y gramáticas escolares.

L’objectif de cet article est de montrer que le concept de barbarie tel que Henry en fait usage dans sa phénoménologie radicale renvoie en dernière instance à un mouvement de naturalisation de l’adhésion des individus au pâtir de leur vie, cette naturalisation du désir de s’éprouver des individus allant de pair avec un déni de sa dimension radicalement intersubjective. En ce sens, notre hypothèse est que certaines des thèses de La barbarie ne peuvent être véritablement comprises qu’à partir d...

Últimamente, y en especial a partir del enfoque de capacidades y funcionamientos de Amartya Sen, se han cuestionado las mediciones de pobreza donde se tiene en cuenta sólo una dimensión del bienestar, como es el ingreso, y se ha dado creciente importancia a la medición de la pobreza desde una perspectiva multidimensional. La propuesta de medida de pobreza de tiempo e ingreso LIMTIP toma el trabajo no remunerado invisibilizado como punto de partida para establecer un umbral de requerimientos de tiempo. (...) Si el ingreso del hogar alcanza para compensar el valor de estos déficits de tiempo, entonces serán pobres de tiempo pero no de ingreso ajustado. Si el ingreso no alcanza para comprar sustitutos de este déficit de tiempo, entonces las personas y los hogares en que habitan serán pobres de tiempo e ingresos. La medida de pobreza de ingreso y tiempo LIMTIP corrige medidas de pobreza absoluta a las que estamos acostumbrados para hacerlas más fieles a sus supuestos. Este trabajo incorpora la dimensión temporal a la medición de pobreza utilizando la metodología LIMTIP sobre datos de la Encuesta de Uso de Tiempo y Voluntariado realizada en la ciudad de Rosario en 2010. (shrink)

This article presents, first, the theoretical framework about democratic schools based on a three-year research project “Demoskole: Democracy, Participation and Inclusive education in schools” funded by Spanish Government. Secondly, it analyses some democratic educational practices and, finally, it communicates some implications of what is supposed to improve the democratic quality of schools increasing the participation of pupils.

Bu araştırma, dijital bağımlılık kavramını ve dijital çağın zararlı etkileri karşısında çocuk, dijital medya ve ebeveyn ilişkisinin sınırlarını tartışmaktadır. Araştırmada 4-6 yaş aralığındaki çocukları günde üç saat ve üzeri dijital medya kullanıcısı olan ebeveynlerin Erken Çocuklukta Dijital Bağımlılıkla Mücadele Seminerlerine katıldıktan sonra çocuklarının dijital medya kullanımına karşı nasıl bir tutum değişikliği göstereceklerine, ebeveyn arabuluculuğu stratejilerinde değişiklik olup olmayacağına cevap aranmaktır. Çalışmada nitel araştırma yöntemi kullanılmıştır. Çocukların günlük yaşantılarında dijital medya araçlarını kullanım durumlarının, sürelerinin, sebeplerinin, çocuk ve ebeveyn açısından yaşanan sorunların (...) tespit edilmesi amacıyla 8 ebeveyn ile yarı yapılandırılmış görüşme yapılmıştır. Elde edilen veriler değerlendirilerek seminer programına son hali verilmiştir. 93 ebeveynin katıldığı 5 hafta süren 10 seminer sonrası seminerlerin tamamına katılan 15 ebeveyn ile odak grup görüşmesi yapılmıştır. Araştırmada dijital okuryazarlık ve dijital ebeveynlik merkezli seminerlerin dijital bağımlılıklarla mücadelede önemli bir basamak olduğu sonucuna varılmıştır. Ebeveynlerin tutum ve davranışları ile çocukların uzun süreli dijital medya kullanımı arasında ilişki olduğu görülmüştür. Ebeveynlerin çocuklarının dijital medya kullanımını denetlemeye başladığı aktif arabuluculuk ve sınırlayıcı arabuluculuk stratejilerini benimsedikleri, teknik arabuluculuk stratejisinin azaldığı, izleme stratejisinden de tamamen vazgeçildiği tespit edilmiştir. (shrink)

A number of two-systems accounts have been proposed to explain the apparent discrepancy between infants’ early success in nonverbal mindreading tasks, on the one hand, and the failures of children younger than four to pass verbally-mediated false-belief tasks, on the other. Many of these accounts have not been empirically fruitful. This paper focuses, in contrast, on the two-systems proposal put forward by Ian Apperly and colleagues. This has issued in a number of new findings. The present paper shows that the (...) theoretical arguments offered in support of Apperly’s account are nevertheless unconvincing, and that the data can be explained in other terms. A better view is that there is just a single mindreading system that exists throughout, but which undergoes gradual conceptual enrichment through infancy and childhood. This system can be used in ways that do, or do not, draw on executive resources and/or working memory. (shrink)

Epistemological contextualism ‐ the claim that the truth‐value of knowledge‐attributions can vary with the context of the attributor ‐ has recently faced a whole series of objections. The most serious one, however, has not been discussed much so far: the factivity objection. In this paper, I explain what the objection is and present three different versions of the objection. I then show that there is a good way out for the contextualist. However, in order to solve the problem the contextualist (...) has to accept a relationalist version of contextualism. (shrink)

There are many things that could be wrong with foundationalism. For example, some have claimed that a so‐called basic belief cannot be both 1) a reason for non‐basic beliefs and 2) such that it cannot be provided with at least prima facie justification.1 If something is a reason, they say, then that something has to be a proposition (or sufficiently proposition‐like) and if it is a proposition (or sufficiently proposition‐like), then it is the kind of thing that requires a reason (...) in order to be even prima facie justified.2 Another reason that some give for rejecting normative foundationalism is that it leads directly to skepticism.3 There is no way, they claim, to move from so‐called basic propositions (typically given as first person introspective reports) to “external world” propositions by employing normatively acceptable principles of reasoning.4 Still others have thought that the invention of a nonrea‐soned reason was as ad hoc as the invention of an unmoved mover.5. (shrink)

This article examines the forces that have made federal scientific publication an essentially private enterprise. Particular attention is paid to the rise of the scientific community in the American political system. The period under review begins roughly with 1941 and American involvement in World War II, which coincides with the establishment of the Office of Scientific Research and Development (ORSD). The article examines OSRD's method of conducting federal scientific research, its contractual system, and the new publishing paradigm that it engendered. (...) The article concludes in the 1960s with congressional efforts to revise provisions in Title 17, the. (shrink)

Progress Unchained reinterprets the history of the idea of progress using parallels between evolutionary biology and changing views of human history. Early concepts of progress in both areas saw it as the ascent of a linear scale of development toward a final goal. The 'chain of being' defined a hierarchy of living things with humans at the head, while social thinkers interpreted history as a development toward a final paradise or utopia. Darwinism reconfigured biological progress as a 'tree of life' (...) with multiple lines of advance not necessarily leading to humans, each driven by the rare innovations that generate entirely new functions. Popular writers such as H. G. Wells used a similar model to depict human progress, with competing technological innovations producing ever-more rapid changes in society. Bowler shows that as the idea of progress has become open-ended and unpredictable, a variety of alternative futures have been imagined. (shrink)

Protochemistry. The Program of a Methodical Foundation of Chemistry. "Protochemistry" - in analogy to protophysics - is sketched as the program of a methodical foundation of chemistry. "Foundation" means to reconstruct the methods (both linguistic and poietic) which lead from the prescientific every-day-practice of mastering properties of substances to scientific theories of modern chemistry. Four types of chemical terms are distinguished, depending on different methods of definition and different areas of reference. Consequences of the program if realized are pointed out.

images. But clearly, it only begs the deeper questions.

This book offers a discussion of practical as well as theoretical autonomy.

Gilbert Ryle wrote that "Meaning-theory expanded just when and just in so far as it was released from that 'Fido'-Fido box, the lid of which was never even lifted by Meinong". This paper sets out to relieve Ryle's oversimplification about Meinong and the role of meaning theory in his thought. One step away from canine simplicity about meaning is the recognition of a distinction between sense and reference, such as we find in Frege, Husserl, and the early Russell. In Über (...) Möglichkeit und Wahrscheinlichkeit (1915) Meinong seems to corroborate Ryle when he writes, "Word-meanings are objects", but immediately after this, he qualifies it: "Word-meanings are very often auxiliary objects". The distinction between auxiliary and target objects in Meinong's later work allows us to attribute to him a theory of sense and reference which shows him to have indeed lifted the box-lid. (shrink)

Agricultural Enlightenment explores the economic underpinnings of the Enlightenment to argue the case that the expansion of the so-called knowledge economy in the second half of the eighteenth century powerfully influenced governments and all those who worked in agriculture, or who sought to derive profit from the productive use of the land.

A democratic ethics of biological technology must engage the public. This is not easy to do in a way that satisfies the demands of democratic ethics, or meets the pace of rapidly changing, complex technology. This paper describes a solution proposed by the University of British Columbia’s Norms Evolving in Response to Dilemmas interdisciplinary research group. The solution, the NERD web survey, has three distinct advantages over other methods: it is Deep—the survey provides deep data, particularly when compared to alternatives (...) such as polls and focus groups; Cheap—our survey is cost effective, which is important for a truly democratic tool; and Improvable—the NERD survey is a work in progress, improvable by design. (shrink)

The early modern distinction between primary and secondary qualities continues to have a significant impact on the debate about the nature of color. An aspect of this distinction that is still influential is the idea that the mind-independence of color requires that it is a primary quality. Thus, using shape as a paradigm example of a primary quality, a longstanding strategy for determining whether color is mind-independent is to consider whether it is sufficiently similar to shape to be a primary (...) quality. However, I’ll argue that the idea that the mind-independence of color requires that it is a primary quality is mistaken, and that, to the contrary, while color is not a primary quality, it is mind-independent. I’ll propose an alternative understanding of what the mind-independence of color requires. This alternative models color perception on an information filter. According to this model, mental qualities that I’ll call media qualities are involved in color perception. The involvement of mental qualities suggests mind-independence. However, I’ll argue, their involvement is modeled after the qualities of a kind of filter that provides access to, but does not constitute, filtered qualities. (shrink)

This book brings together the study of two great disciplines of the Islamic world: law and philosophy. In both sunni and shiite Islam, it became the norm for scholars to acquire a high level of expertise in the legal tradition. Thus some of the greatest names in the history of Aristotelianism were trained jurists, like Averroes, or commented on the status and nature of law, like al-Fārābī. While such authors sought to put law in its place relative to the philosophical (...) disciplines, others criticized philosophy from a legal viewpoint, like al-Ghazālī and Ibn Taymiyya. But this collection of papers does not only explore the relative standing of law and philosophy. It also looks at how philosophers, theologians, and jurists answered philosophical questions that arise from jurisprudence itself. What is the logical structure of a well-formed legal argument? What standard of certainty needs to be attained in passing down judgments, and how is that standard reached? What are the sources of valid legal judgment and what makes these sources authoritative? May a believer be excused on grounds of ignorance? Together the contributions provide an unprecedented demonstration of the close connections between philosophy and law in Islamic society, while also highlighting the philosophical interest of texts normally studied only by legal historians. (shrink)

This is a critique of Nietzsche's theory of culture that proposes an alternative paradigm allowing a defense of the humanities against such Nietzschians as Leo Strauss and Derrida.

This piece offers an edition, translation, and analysis of a newly discovered text by Yaḥyā Ibn ʿAdī, a leading Aristotelian of the Baghdad school in the tenth century. It briefly discusses what Aristotle meant, at the end of the Physics, by saying that the Prime Mover is “in” the outermost heaven. Ibn ʿAdī argues, in part through an exhaustive discussion of the senses of the word “in,” that God is in the sphere only in the sense that an object of (...) intellection is in an intellect. This solution is discussed against the background of ancient commentaries on the same passage. (shrink)

Immunofluorescent labelling demonstrates that human metaphase chromosomes contain hyperacetylated histone H4. With the exception of the inactive X chromosome in female cells, where the bulk of histone H4 is under‐acetylated, H4 hyperacetylation is non‐uniformly distributed along the chromosomes and clustered in cytologically resolvable chromatin domains that correspond, in general, with the R‐bands of conventional staining. The strongest immunolabelling is often found in T‐bands, the subset of intense R‐bands having the highest GC content. The majority of mapped genes also occurs in (...) R‐band regions, with the highest gene density in T‐bands. These observations are consistent with a model in which hyperacetylation of histone H4 marks the position of potentially active gene sequences on metaphase chromosomes. Since acetylation is maintained during mitosis, progeny cells receive an imprint of the histone H4 acetylation pattern that was present on the parental chromosomes before cell division. Histone acetylation could provide a mechanism for propagating cell memory, defined as the maintenance of committed states of gene expression through cell lineages. (shrink)

Fundamental differences between current and past knowledge in the field of biotechnology mean that we now have at our disposal the means to irreversibly change what is meant by ‘human nature’. This paper explores some of the ethical issues that accompany the attempt to increase scientific control over the human genetic code in what amounts to a diminishing of difference and the reduction of human life to scientific explanations at the expense of spiritual, cultural and communal considerations. Within such a (...) limited view, the critical role of education is reduced in favour of promoting psychological efficiency, with the possibility of accelerating learning and increasing intellectual capacity through genetic manipulation. A major concern expressed in the paper is the fine line between corrective therapy and psychological enhancement: Who should be defining the normal range of human difference? And what degree of caution should be required in redesigning future generations? The unknown dangers inherent in the application of genetic technology to human life suggests that current precautions may not go far enough in recognising that education is a contestable field. (shrink)

Comprised of classic and newly-commissioned papers from leading theorists, this volume provides a wide-ranging critical introduction to the thought of Jürgen Habermas. Some contributions explore the relation between Habermas's philosophy and the thought of major predecessors, including Kant, Hegel, Marx and Heidegger. Others elucidate the political context of Habermas's thinking, while a final section presents the responses of leading German contemporaries to his work. The result is a more rounded picture of Habermas's oeuvre and achievement than has previously been available. (...) Habermas emerges as a thinker whose outstanding powers of renewal and innovation are inseparable from his engagement with the major traditions of European thought, and his own intellectual and political context. (shrink)