Melatonin, the chief hormone of the pineal gland, is produced and secreted into the blood in a circadian manner with maximal production always occurring during the dark phase of the light dark cycle. Whereas the 24h rhythm of melatonin production is very robust in young animals including humans, the cycle deteriorates during ageing. The rhythm of melatonin can be substantially preserved during ageing by restricting the food intake of experimental animals; this same treatment increases the life span of the (...) animals. The exogenous administration of melatonin to non‐food restricted animals also reportedly increases their survival. Moreover, melatonin has been shown to have immunoenhancing effects and oncostatic properties. The implication of these studies is that melatonin may have both direct and indirect beneficial effects in delaying ageing processes or it may retard the development of processes (e.g., immunodeficiency and tumor growth) which contribute to a reduced life span. (shrink)

In "Connect: how to find clarity and expand your consciousness with pineal gland meditation", Lee shows how to connect to your authentic self through the pineal gland in your brain. Activate your pineal gland through the meditations rooted in an ancient Korean tradition that Iichi Lee describes in this book. You'll experience clarity instead of emotion, compassion rather than judgment, and wholeness in place of separation. This book will help you find the solutions you seek by opening (...) the inner eye that leads to greater clarity regarding the health of your body, the dreams of your soul, and the wisdom of your spirit. (shrink)

The mammalian pineal gland contains two types of N‐acetyltransferases which act on aromatic amines. One type preferentially acetylates arylamines such as phenetidine and aniline, whereas the other preferentially acetylates arylalkylamines such as tryptamine and phenylethylamine. The two enzymes can be distinguished by (1) molecular size, (2) regulation, and (3) inactivation characteristics. Arylalkylamine N‐acetyltransferase is involved in the regulation of melatonin synthesis in the pineal gland. A specific function of pineal arylamine N‐acetyltransferase has not been established; it may (...) function as a nonspecific detoxification mechanism. (shrink)

Berkeley is best known for his immaterialism and the texts that extol it—the Principles of Human Knowledge and Three Dialogues Between Hylas and Philonous. He made his case by treatise, then by dialogue, and this tendency towards stylistic experimentation did not end there; this paper explores an early speculative fiction project that pursued his theological and philosophical agendas. Berkeley used satire to challenge his “freethinking” philosophical opponents in “The Pineal Gland” story published in The Guardian in 1713. Echoing the (...) grand tours Berkeley undertook in subsequent years, Part 1 offers a “gland tour” of some literary motivations, influences and legacies of these essays. Berkeley pursues heroic themes from Homer and Alexander Pope, while lampooning the philosophies of both Descartes and the freethinkers. Armed with the device of a magic snuff that transports him to the pineal glands of his adversaries, Berkeley's protagonist uses it “to distinguish the real from the professed sentiments of all persons of eminence in court, city, town, and country”. (Guardian, p. 187) Part 1 examines ‘The Pineal Gland’ in the context of Berkeley's broader philosophical legacy and the text's significant engagement with the literature of Homer and Pope, concluding that “The Pineal Gland” is an important but overlooked source in the history of early speculative fiction. Part 2 continues this analysis by exploring Berkeley's relationship with an expansive London literary circle, interrogating a line of influence beginning with the writing of Margaret Cavendish. In doing so, Part 2 also examines Berkeley's complex attitudes towards women. (shrink)

Behind the third ventricle of the human brain a miniscule pedunculate bud, close to the optic thalamus, that is, to the two beds of optic nerves, a gland soft in substance yet containing gritty particles. Function: unknown. Because of its pine-cone shape it is called the conarium or pineal body, even though the recent photographs of it by Nilsson and Lindberg show it to be morphologically reminiscent of nothing so much as the plucked tail of a gamebird, which Simon (...) Dedalus refers to as ‘the pope's nose’. Today it is presumed to be an endocrine gland of some sort, even though there is no doubt that morphogenetically in all vertebrates it is a vestigial unpaired eye. As fossil evidence indicates—and we still find it almost fully developed in some extant amphibians—ancestral vertebrates possessed in addition to the paired bilateral eyes a solitary dorsal eye opening at the top of the skull to the sky. This singular evagination of the brain—something betwixt a visual organ and a gland—seems to hold a special fascination for philosophers. Here we shall consider two of them: René Descartes (1596–1650), the father, as we say, of modern philosophy; and Georges Bataille (1897–1962), the father, as many say, of post-modern philosophy. Three hundred years separate them. Devotion to the pineal body conjoins them. (shrink)

This chapter discusses Descartes thoughts on the seat of the soul or that part of the body which the soul is directly and intimately united. Descartes explains the simplicity principle: If the soul is simple, or indivisible, it can interact directly with only one object at once, thus indivisible. For example, if an animal's heart is taken and cut into pieces, the soul's indivisibility means that the soul cannot act directly upon the dissected parts of the heart. Descartes also consistently (...) identified the pineal gland as the seat of the soul— partly because it was mobile, durable, protected from outside influence, and accessible to the nerves. It also explains that the mind is not affected by all parts of the body, but only the brain and one small part of the brain only where a certain part of the brain is affected while other parts are doing other things. This chapter finally reveals that the simplicity principle of Descartes will have strong difficulties in the final analysis in relation to the truth of God. (shrink)

A ghost is a supernatural being that is typically described as capable of appearing to, speaking to, and even doing harm to a person. But it is also described as a being that you cannot touch or affect in the usual ways. Lots of things seem weird at first, but humans don't think of them as supernatural. It's easy to see how material things interact with each other. After all, they are, by their very essence as things filling space, things (...) that cannot merge into each other. Descartes' view is not just a philosophical speculation; it is also a scientific hypothesis. Although Descartes' reasons for dualism are based primarily in deep philosophical meditation, his reason for identifying the pineal gland as the seat of the soul is based in his investigation of the human brain where Descartes finds an anatomical explanation for some obvious facts about human perception. (shrink)

The aim of this text is to investigate if it is possible to attribute to Plato a dualistic conception of human nature, that is, whether the philosopher can be inscribed in the line of thinkers who establish the so-called “Mind-Body Problem”. In various passages of Platonic Dialogues we can see that the body and the soul constitute two different and quite incompatible natures. On the other hand, the relationship between body and soul is constitutive of human being and is unquestionable (...) in the act of perception. Our study develops in three moments. At a first time we explain the reasons why it is justified to claim that there is in Plato’s Dialogues a difference between soul and body; afterwards, we analyze the relationship between soul and body just as an essential attribute of human nature; we bring about the investigation with the analysis of the “Plato’s pineal gland”, specifically, the element that allow us to consider the liaison between soul and body as a “dual relationship”, that is, not as an undifferentiated unit, nor as a juxtaposition of elements unrelated to each other. Our proposal consists in showing that the mathematical structure, proportional, harmonic and musical crosses all reality: the cosmic body and soul, as well as the human body and soul. (shrink)

I contend that Descartes’s view of mind-body union is not a Platonic view in which the soul uses the body as its vehicle, but hylomorphic in that mind and body form a single unit. I argue that Descartes’s view is most like Ockham’s, and therefore Descartes is entitled to maintain a hylomorphic theory to the same extent that Ockham is. I argue further that the soul is the substantial form of human being, and that mind and body are incomplete substances (...) that are substantially united to form the human substance. Finally, I address Descartes’s claim that the whole soul has its principle seat in the pineal gland, and conclude that this does not imply a Platonic view as one might suspect. This hylomorphic interpretation avoids the problem of mind-body interaction, which might be seen as preventing the possibility of the soul’s immortality, because an explanation of the behavior of one entity is required instead of an explanation of the interaction between two, apparently incompatible, entities. (shrink)

Descartes, the textbooks say, divided human beings, or at least their minds, from the natural world. This is not just the consequence of metaphysical dualism, but of the concomitant indirect ‘ideas’ theory of perception. On the standard view, the soul must dimly infer the nature of the external world from the meagre, fragmentary, and often misleading input which is causally transmitted from objects through the nervous system to the brain and, ultimately, to the pineal gland. The metaphysical solipsism of (...) the cogito, on this picture, has its psychophysiological counterpart in the way Descartes sets all goings-on in nature at such a distance from the knowing subject who is temporarily and imperfectly united with a physical body. We cannot be sure, after all, that there are human beings rather than mere automata under the hats and cloaks we see from our window. (shrink)

An exploration of our fall from the pinnacle of human evolution 200,000 years ago and how we can begin our return. Explores recent neurological and psychological research on the brain and the role of plant biochemistry in human brain expansion. Explains how humanity's prehistoric diet change led to a neurodegenerative condition characterized by aggression and a fearful perception of the world. Outlines a strategy of raw foods, tantric sexuality, shamanic practices, and entheogens to reverse our mental degeneration and restore our (...) advanced abilities. Over a period of a million years the human brain expanded at an increasingly rapid rate, and then, 200,000 years ago, the expansion abruptly stopped. Modern science has overlooked this in order to maintain that we are at the pinnacle of our evolution. However, the halt in brain expansion explains not only recently uncovered anomalies within the human brain but also the global traditions of an earthly paradise lost and of humanity's degeneration from our original state of perpetual wonder and joy. Drawing on more than 20 years of research, authors Tony Wright and Graham Gynn explore how our modern brains are performing far below their potential and how we can unlock our higher abilities and return to the euphoria of Eden. They explain how for millions of years early forest-dwelling humans were primarily consuming the hormone-rich sex organs of plants--fruit--each containing a highly complex biochemical cocktail evolved to influence DNA transcription, rapid brain development, and elevated neural and pineal gland activity. Citing recent neurological and psychological studies, the authors explain how the loss of our symbiotic fruit-based diet led to a progressive neurodegenerative condition characterized by aggressive behaviors, a fearful perception of the world, and the suppression of higher artistic, mathematical, and spiritual abilities. The authors show how many shamanic and spiritual traditions were developed to counteract our decline. They outline a strategy of raw foods, tantric sexuality, shamanic practices, and entheogen use to reverse our degeneration, restore our connection with the plant world, and regain the bliss and peace of the brain of Eden"--Provided by publisher. (shrink)

There is unquestionably a plethora of details and mysteries regarding the mind and the body. However, with the advent of psychopharmacology (the study of how psychedelics inform or alter brain states) there are more issues at hand. Do psychedelics allow us to access deeper areas of our consciousness? Are we having a spiritual experience under the influence of psychedelics? Dr. Rick Strassman does not want to continue asking these rather conspiratorial-like questions. Instead, Dr. Strassman believes that there is one special, (...) endogenous psychedelic, synthesized within the human physiological framework: N, N-Dymthethyltryptamine. Dr. Strassman concludes that this chemical is produced within and around the pineal gland, and is often the catalyst for spiritual and religious experiences. I will explore this topic further under the framework of discovering whether a naturalistic type explanation of spiritual experiences accounts for all types of spiritual experiences and whether one may be rational or justified in believing in God if a naturalist could explain spiritual experiences. (shrink)

As is well known, Descartes’ doctrine on the relations of mind and body involves at least the following two theses: the real distinction of mind and body is compatible with their substantial union; and the siting of the mind at the tip of the pineal gland is compatible with its presence throughout the body. Th is essay seeks to perform three main tasks. One is to suggest that, so far as Descartes is concerned, the doctrine that arises out of (...) the combination of and blocks off the problems that are alleged to arise for mind-body interaction. A second is to illustrate how, in a certain vision of Descartes’ thought, and are more closely connected to each other than is generally explicitly recognised. And a third is to illustrate how one grade of mixture of stuff-types that the ancient Stoics envisaged both provides a model for answering Descartes’ demands and has a reputable pedigree within the tradition to which he was heir. (shrink)

This volume presents new research on Cartesian psychophysiology that combines historical and textual analysis with a consideration of recent advances in contemporary neuroscience research. It seeks to explain why the theory of the Cartesian brain and its communication with the mind still offers a remarkable model for cognitive studies. New research in the philosophy of mind and cognitive science has reignited interest in the role and the structure of the "Cartesian brain" among scholars of Descartes. This volume rethinks Cartesian psychology (...) from the perspective of physiology, with the aim of redetermining the contributions of the brain and central nervous system to mental phenomena. The first part of the volume concerns the details of Descartes's own physiological account of the brain. The discussion covers his treatment not only of the anatomy of the brain, but also of the mode of interaction between mind and body, in which the pineal gland plays a central role, and of the relation between the brain and the rest of the body. The second part considers the reception and legacy of the Cartesian brain. The focus here is on understanding how Cartesian psychophysiology was received by Descartes's early modern contemporaries and immediate successors, as well as on the relevance of the Cartesian brain for contemporary neurophysiology and cognitive science. The Cartesian Brain is an essential resource for scholars and advanced students interested in Descartes, history of philosophy, history of science, philosophy of mind, and cognitive science. (shrink)

Where is the self located in the brain? This is a question that has intrigued philosophers and scientists for quite some time. Four centuries ago, the French philosopher René Descartes thought that the self resided in the pineal gland, a small structure centrally positioned in the lower brain.

Most philosophers have regarded humans as a psychosomatic reality, considering the individual human being as a unity composed of two distinct dimensions: immaterial and material, which are interrelated. However, the manner in which these two distinct substances relate to each other has leaded humanity to numerous challenges. Hence, Descartes and Mulla Sadra, have attempted to elucidate the relationship between the mind and body. Therefore, comparing thoughts of Mulla Sadra and Descartes regarding the issue of the mind and body, along with (...) the proposed solutions by these two philosophers, can address numerous human inquiries regarding the dual constituents forming the reality of human existence. This article, using a descriptive-analytical method, comes to conclusion that Descartes considered the pineal gland as the primary agent of the interaction between the mind and body, whereas Mulla Sadra, based on the theory of material creation and substantial motion of the mind, deemed the interaction between the mind and body feasible. (shrink)

June 2022 A Revolutionary New Metaphysics, Based on Consciousness, and a Call to All Philosophers We are in a unique moment of our history unlike any previous moment ever. Virtually all human economies are based on the destruction of the Earth, and we are now at a place in our history where we can foresee if we continue on as we are, our own extinction. As I write, the planet is in deep trouble, heat, fires, great storms, and record flooding, (...) weather patterns drastic everywhere. Capitalism has been so successful in supplying us with an endless array of consumer items, that we have never noticed there is a cost. But there is a cost, the cost is the very life of the Earth herself, and now the day of reckoning is here. Days of reckoning are most often days of rath. But I am hoping that this is a day of major Awakening over the entire planet. We have caused a crisis so great for the Earth we can hardly get our minds around it. But I am proposing that deeply embedded in the crisis are ideas, about who and what the Earth is, Ourselves, and what we are here for. I am proposing that this is a call to all philosophy and philosophers to rethink ourselves from the ground up. The human race has never gotten the Earth right and now we must, for the Earth is the true foundation for civilization. We are in deep trouble with the Earth, and it owes to the fact that the great male thinkers never got the Earth right, they could never make the connection between the life of mind and the life of the Earth. I am proposing that deeply embedded in the crisis we are in are ideas. And that in fact the planet is in the grip of a false metaphysics, and scientific image of nature that really comes most recently from Descartes. His conviction that matter, and with it the Earth, are simply the weighable, the measurable the extended in space and time, utterly devoid of any inner life of mind thoughts or Consciousness. This view of matter and the Earth goes back to the very dawn of thought, Descartes is just its most recent and comprehensive version of things. This view of matter is really a false metaphysics that dominates most of the modern world and underpins the whole scientific image of nature itself. I am proposing this is a false metaphysics and offering a new version of things based on Consciousness. If there is a single idea fueling and driving the destruction of the planet, it is the conviction that the Earth is something without Consciousness. When you intend to ravage and savage the planet, turn it into consumer items to be converted into money in the bank, first pretend that all of the bright beings in the natural world are devoid of Consciousness, just “things” you do not have to have any conscious about destroying them. I am proposing that this term Consciousness, that has appeared as term and a problem for modern science, is the key to getting ourselves right with the Earth. I propose this new theory for science will ramify into every other disciplines as well, and the ways we think just about everything. This old paradigm based on a false theory of matter, has run its course, it has brought us to the brink of our own extinction. We need new ideas, and we need them now. You will find my recent work in the Scientific God Journal under the title: Consciousness as the Organizing Principle, and a very complete version of my arguments for this term Consciousness, along with radical reinterpretation of modern science itself, on the Galileo Commission site. It is a radical moment for all of the thinkers among us, take this as my small contribution to rethinking ourselves in new terms, based on my understanding that the true basis for the whole of Being, the Universe, the Cosmos, and with them Ourselves, is this term Consciousness. And unpack it. And I predict that with this term Consciousness every intractable human problem in both science and the modern world will go down like a line of dominos before it. And so, here are a few new ideas I would offer you. These are the times of the Reappearance of the Feminine, a great Awakening as of Springtime after a long dark and lonely Winter. We are leaving behind us an old civilization based on male dominance, fear lies and control, now in decay, disease, and death disintegrating all around us. We are moving into a whole new civilization based on Love and Truth. A new civilization requires new basic terms values and first principles. And so, I return to Descartes. 1. Just over 300 years ago a young man travelling with the army found himself stranded in a foreign town in a bare room lit by a candle with nothing to do but think. And in a couple of nights Descartes laid the entire thought foundations for modern science and most of the modern world. It isn’t clear that modern philosophers with their funding sources of grants, their graduate students, their reputation and all the perks and privileges of academia can do any better. Descartes claimed there are just two principles in the Universe, Matter and Mind. God was pure mind; human beings were mind and matter. And we are the only ones on the planet with mind. Everything else all of the bright array of beings who share the planet with us are simply matter. And matter? The weighable the measurable the extended in space and time utterly devoid of any inner life of thoughts, feelings, or Consciousness This classification was a boon for developing science. Scientists did not have to worry about any inner life in nature, ideas or Consciousness, they could just set about weighing and measuring, as they have until the present day. But it was a disaster for the Earth. Earth was once worshiped as a Goddess. With Descartes she became almost overnight “things.” Simply commodities and resources, an endless of supply of consumer items, to be turned into money in the bank. And now Descartes concept of matter is up for us. If there is a single idea that is enabling and driving the destruction of the Earth, it is the conviction that Earth is something without Consciousness. This whole scientific image of nature as something devoid of Consciousness is driving the destruction of the Earth, and driving us all insane, and it needs to change. Ever since Descartes formulated Dualism, scientists and philosophers have been trying to get rid of it. They have done this by attempting to make matter the fundamental term of reality, and to explain mind or Consciousness in terms of matter. And now, Consciousness has emerged as term and a problem for modern science. 2. The prevailing Universe picture has been mainly based on the belief that Consciousness appears only at the end of evolution in ourselves and some of the higher animals when matter attains “a certain state of complexity” and it is produced by neurons in the brain. But Consciousness is nothing real in itself, the neurons are doing the work, Consciousness is simply a byproduct of neural activity. As William James summed up this position, not his: Consciousness is to the brain as a shadow to the runner, it runs beside him but never influences his stride. And so, the great problem of neuroscience: How do neurons produce Consciousness? So far, no one has been able to say how. All we have is parallelism. Two processes are running in parallel a train of neural events and a train of Consciousness events. And so, which one is primary? The face of neuroscience and much of the modern world is that the neural events are what is really real, Consciousness is secondary. The conviction that Consciousness is something produced by neurons is so deeply held and has been so for so long, that it seems like an obvious fact. It is in fact an assumption and a theory, and it could all well be the other way around. The scientific image of nature as something devoid of Consciousness is now up for us. It has enabled the destruction of the Earth, and we are now at a unique place in our own evolution where we can foresee if we continue on as we are, our own extinction. And so, there are the best reasons for rethinking Descartes concepts of matter. Scientists and philosophers have been trying to escape dualism by making matter the fundamental term. And now, this has not worked. In a nutshell: The mind body problem, the “hard problem of Consciousness” ---how do neurons in the brain, atoms and molecules give rise to ideas thoughts and feelings and who what and where is the “I” who sees them? And then, the near-death experience. I remind you of the truth of the near-death experience. The body in the bed is brain dead eeg flat, but the patient, pure Consciousness is hovering at the ceiling watching the doctors work over the body below, able to read dials he could not have seen from the bed, sometimes able to events in the corridor beyond the room, all subsequently confirmed by the doctors. Evidence as good as it gets that the patient really was out of his body. And so, the patient is able to see without eyes, hear without ears and to think and remember without a brain. There is not a single scientific principle that can account for this. And I am proposing that the near-death experience is a threshold and a key for a much deeper understanding of the Universe. These three problems are so hard they cannot be solved by present scientific principles and therefore call all present principles and ways of thought into question. When your axioms cannot account for the data, it is time to drop them and find better fundamental terms. We have not been able to solve the problems of Consciousness with the assumption that matter is the most basic and fundamental term. And so, if Cartesian dualism is to be overcome at all, we need to try it the other way around. 3. We are in the position of Copernicus. Remember Copernicus? He was making his calculations on the assumption that the Earth was the center of the Universe until they became so unwieldy that he decided to try it all the other way around. To make the sun the center, the Earth revolving around it. And lo, all of his data fell neatly into place. I am proposing a whole new Universe picture. Evolution makes us continuous with every other being, Consciousness would not be in us if it were not in them also, and then, in the atoms and molecules and cells that make up living beings. I propose to make Consciousness the most basic term and see what follows. I am in fact, proposing a new Copernican Revolution, that Consciousness is the true basis for the Universe and the right fundamental term, for science itself all other disciplines as well, and the whole of the modern world. And I predict that every intractable problem in science or the modern world, will go down like a line of dominos before it. In a nutshell: Consciousness and not matter is “first and fundamental” in the Universe, it is there from the very “Beginning” everything has it and all of the true causalities, the explanatory principles belong to it. Not to matter. What then is matter? All matter is an Appearance of something much more real, Consciousness. All matter is an expression of Consciousness, even the least little bit of matter contains Consciousness, and is an expression of Consciousness. And so, we revise the scientific image of nature. Science at present is two termed, matter/energy. It needs to become three termed: Matter/energy/Consciousness, with the recognition that all of the basic principles, the true causalities of events, and of the Universe belong to Consciousness. And now physics. To accommodate this new Universe picture physics needs to alter just one term, energy. All energy contains Consciousness, that idea alone will change our world forever. The animals the trees the plants are just as conscious as we are, as is the Earth herself, a continuum of many forms of Consciousness of which our own is one. The Earth consists of interacting and intersecting forms of Consciousness, Consciousness within Consciousness within Consciousness within Consciousness. A remarkable work has just appeared entitled “Beyond Words What Animals Feel and Think.” Describing in detail how like ourselves all of the animals are. And the more we can see how like us everything else really is, the harder it will be for us to do them all in, in the interest of turning them into consumer items. And so, here is a new principle of understanding, that entails completely new forms of explanation, and a whole new Universe picture to be spelled out in terms of Consciousness and its various properties. This is a Universe that is aware awake and Enspirited throughout. And so, there is only one principle, not two. And so, how does Consciousness work? There is “no mind/body problem.” My Consciousness is aligning the Consciousness of neurons in the brain, that aligns the Consciousness of all other cells in the body, that aligns the Consciousness of molecules and atoms themselves. Mainly from the top down, but also interactive, and not reduction to the purely physical forces. 4. And so, here is a radical new Universe picture, and with it a new way to think about the Universe itself, the Earth, Ourselves, and Spirit. It requires a complete revision of both of the terms of modern science itself. The problem of the modern world owes in deep measure to Descartes concept of matter as something devoid of interior life. But he is only the most powerful and simple expression of a whole tradition of thought that predates him, that goes back to the very dawn of thought itself. It owes to the conviction of both Plato and Aristotle that the Earth was something devoid of reason, or mind, and therefore something to be held in complete contempt. We are emerging from a civilization based on contempt for the Earth, and down the road, it will become contempt for the body, sex, women, the Native people, and people of color everywhere. And so, this entire tradition is now up for us, it has brought us to the brink of our own extinction, and we need to get beyond it. I am proposing that this term Consciousness is the way out. The missing piece of the puzzle and the idea whose time has come. And it will enable us to move into a completely new civilization based on respect for the Earth, women, sex, people of color, that honors everyone and has a place for all. Revolutions in science occur when new data show up that cannot be accounted for by existing paradigms (Thomas Kuhns: The Structure of Scientific Revolutions). Consciousness, and all the properties and problems of Consciousness are just such data, and they compel a new scientific revolution. But we are a scientific age. A new Copernican revolution in science is such as revolution everywhere. And Consciousness is the key to getting every other reality at all levels and depths right as well. It will enable us finally to get the Earth right, get ourselves right with the Earth, and with one another. Archimedes: Give me a place to stand, and I will move the world. I am proposing a new synthesis among our fundamental terms in which this term Consciousness is the new lynchpin. And so, I return once more to Descartes. Descartes in the Mediations was a dualist, they were two realities interacting in the pineal gland mind and body. But Descartes age was high on “Cartesianisms,” on Descartes concept of matter. Animals were simply cleverly wired machines (Hobbes called them automata). Rumor had it that Descartes followers went about kicking dogs reasoning that their howls were not due to any feelings of pain, but simply the wiring of the machine. We have been doing this to the Earth ever since, and now the Earth is not going to stand for it any longer. It is time we all woke up. There is no matter in Descartes sense of it, or in Plato and Aristotle’s sense of it. This old concept of matter is embedded in all of the crisis and catastrophes---fires, drought, pandemics, over population, the disintegrating economies, our ways of life, capitalism and consumerism themselves. All matter is Enspirited, contains Consciousness, and is an expression of Consciousness. Now I tell you something about Descartes you may not know. In the Mediations was a dualist, there are minds and bodies. But by the end of his life, he knew the truth. Descartes guided his whole life by these vivid dreams, and toward the end of his life he had this dream: He saw the Universe as a giant machine and in the heart of the machine propelling the whole, was Consciousness. And so, out of the shades and shadows and into the light of day. Here is a renewed and a new science, a new cosmology. And with it, a revolutionary new metaphysics. The whole of the modern world is in the grip of a false metaphysics, based on Descartes theory of matter. Here is a new, and finally true metaphysics based on the single term, Consciousness. 5. And in all my works, I spell out this new metaphysics based on Consciousness, and what it means for how we think about virtually everything: The Universe, the Earth, Ourselves, and Spirit. Of who, what and where Spirit is, that we may connect with Spirit everywhere. There is only one term for the Universe, and not two, this single term Consciousness, that manifests itself in two modes: Consciousness in Form, Consciousness Formless. And so, here is a sketch of what this new term Consciousness really means. For four great aspects of the real, four new cornerstones for a whole new civilization on Earth, based on Love and Truth. A. For the Universe: New causalities, all matter is an expression of Consciousness, awake and aware, Enspirited throughout, which has a place for the causalities of love ideas intent plan and purpose, what Aristotle called final causality, that for the sake of which. And it has a place for subjectivity, the greatest mystery in the whole of the Universe, knowable only in ourselves, but there in everything else as well, bedrock in the chain of causalities. The buck stops here. Here are two very different Universe pictures. The Cartesian Universe consists of things, pushed, and pulled around by the physical forces that function blind. The true Universe consists of selves and not things. Selves at least in ourselves, are organized and focused about an I, an I am, or a sense of self in everything, ever other being dear to itself. Just one aspect of subjectivity. And so, it is Consciousness all the way down, and subjectivity all the way down. Science proceeds on the basis of the negligible of what it can leave out as unimportant. Subjectivity is the ultimate animating principle of the Universe. What Descartes really did was to strip from nature what is most essential about it, its animating principle Consciousness. And so, we come out of a long history of “clunk.” The great male thinkers have killed creation. First in concepts and now in the lived life. And so, after centuries of fruitless search, not all of it in vain, finally, and just in time the true basic principle for the Universe has shown up in virtually all disciplines, this term Consciousness. B. And so, the Earth: What does this term Consciousness really mean for the Earth? It means that all of the bright array of beings around us have Consciousness. And the more we can realize how like us they are, the harder it will be to do them all in. Is this what it really means to be “made in the image of Spirit?” To destroy ever other living being? The god of Genesis is a creator god who has created billions and billions of living forms. Man, taking himself to be made in the image of Spirit has destroyed virtually all of it. The Earth is not things, not commodities and resources, not an endless array of consumer goods. The Earth consists of conscious living spiritual beings like ourselves, who need to be honored and respected, nurtured and cared for, to be Loved. And if the human race can finally pull it off and bring Love here and start helping the Earth rather than destroying her, even our vast numbers now at 8 billion, may not matter. Deeply embedded in the modern world is a false cosmology based on the hitherto useful but ultimately false metaphysics of Descartes. In particular it owes to Descartes concepts of matter, and of the Earth, as something devoid of Consciousness. And now this concept is up for us. If there is a single idea enabling and driving the destruction of the planet, it is the conviction that the Earth is something devoid of Consciousness. And we all have a vested interest in keeping this false concept in place. When you intend to ravage and savage the Earth, to turn it into consumer items, and money in the bank, first pretend she has no Consciousness that way we need not have any conscious about it. We are in deep trouble with the planet. Virtually all human economies are based on the destruction of the Earth, and we are now at a place in our history where we can foresee if we continue on as we are, our own extinction. And so, here are a few new guiding principles for the planet, based on Consciousness. Consciousness has field properties. The Earth is Consciousness throughout, connected and interconnected throughout, intersecting and interacting fields of Consciousness of which our own is one. To harm one is to harm all. Only this understanding of the Earth can set our destructive technologies, and capitalism, their goals, and their limits. The real problem with capitalism, and with civilization itself is it has no true understanding of the Earth, all the exquisite networks and webworks that connect all beings with one another. Nor it is about to admit that the Earth is our “life support system,” reason gone insane in the modern world. We are destroying our life support system, capitalism is the full expression of the human death wish in the modern world, and it needs to change. And now, let the barriers between ourselves and all other beings go down. C. And so, Ourselves. This new Universe picture based on Consciousness opens into and has a place for new concepts of human identity. In particular, it has a place for reincarnation, a process whereby one Consciousness dons’ bodies again and again and lays them down. This is a process wholly impossible on materialistic theories. This new view of things puts a higher perspective on Freudian determinism, which is a partial knowing in a greater account. We are something more than the victims of genes drives and childhood. We are immortally eternal evolving spiritual beings who take on a cycle of earthly lives in order to achieve certain goals and abilities, and then, our earthly cycle complete, we depart the Earth plane for other areas of the Universe physical or purely spiritual, to continue our evolution elsewhere. The scientific evidence for reincarnation is increasing on all sides, see for example the work of Michael Newton, a mainstream scientist forced to confront the fact of reincarnation. A completely new reincarnational picture is now emerging everywhere. We choose our parents for abilities we could acquire through them. We all come here with reasons for being here, and we all have free will, an original property of Consciousness, and we work out our issues accordingly. We all come here with the same reason for being here. It is to experience the Earth plane and human society at all levels and depths, in every social role, every climate, both sexes male and female and in all races. We are all here to acquire a deep understanding of the Earth plane with all its challenges and all of its present problems. We are not here to devour and consume the Earth, but to honor her for the learning experience she makes available for us. And so, reincarnation is the great equalizer, the fundamental basis for any bill of rights. Many of the problems of the modern world owe to the fact that reincarnation has not been taught in the West. Reincarnation was the center piece of Jesus teachings. It was banned by a fourth century council that decided the populous could best be controlled through fear. They edited all mention of reincarnation from the scriptures, and inserted fear terms instead, a judgmental god, and so on. If reincarnation had been taught, there would have been no suppression of women, but the gift of both sexes would have been honored and developed. And there would have been no reason for contempt for people of color because who they are, we have been or will be. There is no reason to look down on anyone when we know that our own identity includes membership in theirs. The truth of reincarnation needs to be the foundation for getting ourselves right with the Earth, and with one another. D. And so, Spirit. This new Universe picture, based on Consciousness, has a place for Spirit as simply Infinite Consciousness. All universes all worlds are formed out of this Consciousness, divine and sacred throughout. And Spirit is everywhere in the Earth and can be connected everywhere. And the Native North American people had things right. Everything has its own Spirit, and without contradiction is also an expression of Spirit. And what I am really doing in terms of concepts of modern science is presenting the Native North American version of the Real. And this new Universe picture has a place for the essential insight of all religions almost smothered by church tradition: Love. Not an emotion but a great Oneness, that can be found everywhere, even in a busy city street. But especially in the Earth, that is levels and depths of Oneness everywhere. And so, for the first time in their long and bitter antagonistic history, science and religion now share a common base with this term Spirit, the lynchpin in a new conceptual framework. And I offer an interpretation of where we are in our history, this present moment of historical grace, and these tumultuous times in which we live, the return of the Goddess and the Divine Feminine, the Reappearance of the Feminine in history, the Advent of Women, this great Awakening, as of Springtime after a long dark Winter, the Awakening, the Second Coming. And so, stay tuned! (shrink)

The Cartesian explanation of sensation includes a speculative account of how external and internal phenomena transmit information to the brain by triggering flows of animal spirits from the pineal gland. The distinctive patterns in the flow of spirits are called ‘ideas’. There is no reason to think that ideas resemble the realities that cause them. All animals have sensations in this sense, and exhibit corresponding behaviour.

One of the most certain truths in the world is Descartes' "I think, therefore I am". Descartes was so certain of the existence of some kind of essential _self_ that others have coined the term "Cartesian theater" to describe the sense that we all have of being the audience enjoying the rich play of our experiences. We tend to believe in an enduring self, independent of our individual percepts. Sometimes this virtual "self" in our mind, sitting in the audience of (...) the Cartesian theater who watches our thoughts is referred to as a homunculus. This is not necessarily to imply that most of us believe that the self or homunculus is an identifiable region of the brain like the pineal gland, just that at some level of organization, we assume that there is a self that is separate from the stuff that self experiences, remembers, thinks about, etc. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 34.4 (2001) 308-321 [Access article in PDF] Early Modern Emotion and the Economy of Scarcity 1 - [PDF] Daniel M. Gross Where do we get the idea that emotion is kind of excess, something housed in our nature aching for expression? In part, I argue, from The Passions of the Soul (1649), wherein Descartes proposed the reductive psychophysiology of emotion that informs both romantic expressivism and (...) latter-day psychology. Indeed, one goal of this article is simply to recall that we do not just naturally express emotions generated in our amygdala or wherever, but rather that we are first constituted as expressive agents by what the philosophers of the Scottish Enlightenment called "social passions." Contrary, however, to these largely optimistic philosophers, such as Hutcheson and Smith, who anchored social passions in a moral sense equally shared by all, I argue that the constitutive power of emotion derives from their unequal distribution. In what follows I work primarily with Aristotle's Rhetoric and Thomas Hobbes to outline a "political economy" wherein passions are (1) constituted as differences in power and (2) conditioned not by their excess but by their scarcity. Though we may reject the political conclusions reached by Aristotle and Hobbes, their analysis of emotion allows us to address important political questions neutralized in the Cartesian paradigm. 1. Descartes If you are tickled to learn that Aztec culture located passions in the liver, here is something at least as quaint from Descartes: "The ultimate and most proximate cause of the passions of the soul is none other than the agitation with which the spirits move the little gland which is in the middle of the [End Page 308] brain," that is, the pineal gland. Or so Descartes proposes in his 1649 treatise on the passions composed for Princess Elizabeth of Bohemia. Now compare this to Aristotle's Rhetoric, where for instance anger is defined as "desire, accompanied by distress, for conspicuous retaliation because of a conspicuous slight that was directed, without justification, against oneself or those near to one" (1378a 31-33). For Aristotle anger may indeed be accompanied by physical distress, as in the boiling of blood expressed in crimson cheeks, but its proximate cause is anything but that little gland in the middle of the head. Anger is a deeply social passion provoked by perceived slightsunjustified, and it presupposes a public stage where social status is always subject to performative infelicities.Indeed, we can learn a good deal about the rhetoric of human nature in early-modern Europe simply by asking what passions were. When we do, we find not only that their descriptions disagree, but also that the things described as passions seem incommensurable. Are passions tangible "things" residing in the soul, or are they dispositions of the heart or beliefs of the mind? Is passion a matter of personal expression, or is it something essentially social that a person performs? Do they come from our interior, or from the things we perceive? Can they be measured and manipulated--their causes controlled--or do passions elude control by their very nature? Are they divine, diabolical, or human, and can we distinguish them according to the status of their origin? Are they the enabling condition of virtue or its enemy? Are they necessary or disposable? What is their number and what do they do? Exasperated by endless wrangling over such questions, Descartes complains: There is nothing in which the defective nature of the sciences which we have received from the ancients appears more clearly than in what they have written on the passions; for although this is a matter which has at all times been the object of much investigation, and though it would not appear to be one of the most difficult, inasmuch as since everyone has experience of the passions within himself, there is no necessity to borrow one's observations from elsewhere in order to discover their nature. (331) 2With this preliminary remark Descartes renders human nature in its quintessential modern form: it is something housed in a body subject to the self-evidence... (shrink)

For thousands of years voyagers of inner space - spiritual seekers, shamans and mystics - have returned from their inner travels reporting another level of reality that is more real than the one we inhabit in 'waking life'. Others have claimed that under the influence of mysterious substances, known as entheogens, the everyday human mind can be given glimpses of this multidimensional realm of existence that is usually hidden from us by our five basic senses. Using information from the leading (...) edges of modern science, this book presents a startling new hypothesis that these 'inner worlds' are as real, or possibly even more real, than the 'reality' we experience in waking life. The Infinite Mindfield uses as its starting point the widespread historical belief that the pineal gland - the 'third eye' - is a profoundly important organ. It links this to the various myths, originating in ancient Sumer, that 'dragons' or 'serpents' have guided humanity and presents evidence that these beings are symbolic of DNA. It is now known that DNA gives off a form of light known as bioluminescence. This information-rich 'inner light' needs an organ of sight to process it - that organ is the pineal gland. It is through this small organ that we "perceive" the inner worlds of lucid dreaming, out-of-body experiences, hypnagogic imagery, near-death experiences, astral travel and the kundalini experience. The book ends with the mind-blowing proposition that all living beings are one unitary consciousness experiencing itself subjectively. This book is genuinely revolutionary and will cause both interest and controversy in equal measure. Its science is watertight as is its logic. Be ready to be stunned - you will never have read anything like this before. (shrink)

This paper attempts to explore the idea of mind on the basis of René Descartes and Gilbert Ryle’s vision. Descartes, a 17thcentury philosopher, developed a dualistic theory that posits the mind and body as distinct entities. According to him, the mind is an immaterial, non- extended entity with consciousness and rational thought, while the body is a material substance subject to physical laws. In contrast, 20th-century philosopher Ryle rejected the idea of a separate mental realm and argued for the unity (...) of mind and body. He criticized Cartesian dualism, proposing that mental states and mental processes are not separate from bodily behavior but are intricately intertwined with it. This comparative analysis delves into Descartes’s arguments for dualism, including the interaction between mind and body through the pineal gland and his ideas on the mind’s independence from the body. On the other hand, Ryle’s critique of dualism is examined, with a focus on his concept of “category mistake” and his advocacy for behaviorism, which prioritizes observable behavior over unobservable mental states. By exploring these two contrasting perspectives, this paper aims to comprehensively understand the historical development and implications of the notion of mind. It highlights the influence of Descartes’s dualistic framework on philosophical discourse and Ryle’s efforts to challenge it, emphasizing the importance of considering the relationship between mind, body, and behavior in understanding human cognition and experience. (shrink)

Treatment of diseases of the brain by drugs or surgery necessitates an understanding of its structure and functions. The philosophical neurosurgeon soon encounters difficulties when localising the abstract concepts of mind and soul within the tangible 1300-gram organ containing 100 billion neurones. Hippocrates had focused attention on the brain as the seat of the mind. The tabula rasa postulated by Aristotle cannot be localised to a particular part of the brain with the confidence that we can localise spoken speech to (...) Broca's area or the movement of limbs to the contralateral motor cortex. Galen's localisation of imagination, reasoning, judgement and memory in the cerebral ventricles collapsed once it was evident that the functional units-neurones-lay in the parenchyma of the brain. Experiences gained from accidental injuries (Phineas Gage) or temporal lobe resection (William Beecher Scoville); studies on how we see and hear and more recent data from functional magnetic resonance studies have made us aware of the extensive network of neurones in the cerebral hemispheres that subserve the functions of the mind. The soul or atman, credited with the ability to enliven the body, was located by ancient anatomists and philosophers in the lungs or heart, in the pineal gland (Descartes), and generally in the brain. When the deeper parts of the brain came within the reach of neurosurgeons, the brainstem proved exceptionally delicate and vulnerable. The concept of brain death after irreversible damage to it has made all of us aware of 'the cocktail of brain soup and spark' in the brainstem so necessary for life. If there be a soul in each of us, surely, it is enshrined here. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:More About Hume's Debt to Spinoza Wim Klever In a recent contribution to the question of Hume's relationship to SpinozaIadvocatedamoreorlessSpinozisticinterpretationofthefirst bookofA Treatise ofHumanNature.1 Ofthe Understanding, sowasmy claim, is not only very close to De natura et origine mentis (Ethica, second part) as far as its main affirmations are concerned; the convergence ofexternal and internal evidence makes it also probable that there is a remarkable influence from the one's work (...) on the other and, accordingly, that Hume's defamation of Spinoza's system might well have been disingenuous. This last point was previously also suggested by Richard Popkin in an article in which he compared Hume's philosophy ofreligion with Spinoza's.2 What motivated me to continue my research in this field? To say itinone word: the unintendeddiscoveryofmanystrikingresemblances betweenHume's secondbook, OfthePassions,andSpinoza'sthirdpart, De origine et natura affectuum. I happened to become a member of a group ofinterested people who concentrate on reading Hume, and, on the other hand, I had acquired some expertise as a Spinoza scholar for quite a number of years, so that I could not avoid seeing the commonaUties between the two philosophers. It seems to be fully impossible to explain the resemblances—which I, ofcourse, will show below—by referring to the Spinoza-article in Bayle's Dictionaire historique et critique (a source once mentioned by Hume in a letter to a London friend), since Bayle does not spend a word to the human passions. It is further a hard fact that there do not exist other written sourcesfrom which Humemighthave drawnhisSpinozisticinspiration in his French period apart from the Ethics; all available literature of the time turned around the questions theism versus atheism and free will versus determinism, without entering into the details ofhuman emotions.3 Only one conclusion was possible for me: Hume musthave been familiar with Spinoza's own text. Either the Chevaher Ramsay, whose intimate he was for some time,4 or anotherintermediaryfigure5 must have raised his interest. The best entrance into the material is constituted by Hume's closing remark in his A Dissertation on the Passions (1757), in which he elucidates what he in fact has been doing in hie analysis of the passions: Volume XDI Number 1 55 WIM KLEVER I pretend not to have here exhausted this subject. It is sufficient formy purpose, ifI have made it appear, that, in the production and conduct of the passions, there is a certain regular mechanism, which is susceptible of as accurate a disquisition, as the laws ofmotion, optics, hydrostatics, or any part ofnatural philosophy.6 In spite ofthe words "a certain," this fragment maynot be interpreted as a metaphorical assessment. The origin and the processes ofhuman passions are purely mechanical. If this is not what Hume intends to declare, he never could have added the phrase that passions are susceptible of exactly the same kind of accurate descriptions as other natural phenomena. This theory of the mechanism of the passions is certainly not Cartesian. Although Descartes, as a physical scientist, was a great promoter of the explanation of things by means of mechanical causality, he in fact did not extend this method to the life ofthe passions. In his dualistic philosophy he ascribes to the human mind (with its free will) the capability to interfere with the passions and even to dominate them.7 In this field it is Spinoza who paves the way for Hume by sharply criticizing Descartes' non-mechanistic explanation ofthe passions. His far-fetched solution ofthe mind-body interactivity by means of the pineal gland and the animal spirits pushing against it, is called "a hypothesis more occult than any occult quality." 8 Spinoza acknowledged that Descartes had good intentions in trying to explain the human affections by their direct causes, but he was inconsistent insofar as he at the same time attempted to demonstrate man's absolute dominion over them. He, Spinoza, on the contrary, "will consider human actions and appetites just as ifit were a question ofUnes, planes and bodies." 9 The analysis of passions is a piece of natural science comparable with geometry, optics10 and hydrostatics, to mention some other fields of Spinoza's research. Hume's statement... (shrink)

Descartes argued that the passions of the soul were immediately felt in the body, as the animal spirits, affected by the movement of the pineal gland, spread through the body. In Leibniz the effect of emotions in the body is a different question as he did not allow the direct interaction between the mind and the body, although maintaining a psychophysical parallelism between them. -/- In general, he avoids discussing emotions in bodily terms, saying that general inclinations, passions, pleasures (...) and pains belong only to the mind or to the soul (NE II, xxi, §72). He is also keen to point out that our passions derive mostly from our bodies. However, like Spinoza (Ethics III, prop. XI, Scholium) he thought that some emotions such as joy can produce pleasures which can be described also in bodily terms. For example, in a short memoir Felicity he says that music can be a pleasure for the ears and symmetry can be a pleasure for the eyes. These more intellectual emotions are actions in the sense that they represent perfection emanating from their source, the absolutely perfect being, that is, God. The feeling of perfection may produce a state of well-being which concerns both the soul and the body. -/- In my paper I will trace instances of Leibniz’s remarks on how these kind of emotions affect the body. I will also discuss the different ways the body gives rise to passions in the soul. My primary source is Nouveaux essais, book II, chapter xx and xxi, but I will also discuss various other writings by Leibniz. (shrink)

Vertebrates respond to light with more than just their eyes. In this article, we speculate on the intriguing possibility that a link remains between non‐visual opsins and neurohormonal systems that control neuronal circuit formation and activity in mammals. Historically, the retina and pineal gland were considered the only significant light‐sensing tissues in vertebrates. However over the last century, evidence has accumulated arguing that extra‐ocular tissues in vertebrates influence behavior through non‐image‐forming photoreception. One such class of extra‐ocular light detectors are (...) the long mysterious deep brain photoreceptors. Here, we review recent findings on the cellular identity and the function of deep brain photoreceptors controlling behavior and physiology in zebrafish, and discuss their implications. (shrink)

Commenting on the passage in Revelation which says that the people would have the Father's name written on their foreheads, Chapman writes, "The pineal gland, situated about the middle of the head is the 'spiritual gland,' the gland which connects the focalization of the outer, human consciousness with Father-Consciousness."--R. F. T.

Descartes developed an elaborate theory of animal physiology that he used to explain functionally organized, situationally adapted behavior in both human and nonhuman animals. Although he restricted true mentality to the human soul, I argue that he developed a purely mechanistic (or material) ‘psychology’ of sensory, motor, and low-level cognitive functions. In effect, he sought to mechanize the offices of the Aristotelian sensitive soul. He described the basic mechanisms in the Treatise on man, which he summarized in the Discourse. However, (...) the Passions of the soul contains his most ambitious claims for purely material brain processes. These claims arise in abstract discussions of the functions of the passions and in illustrations of those functions. Accordingly, after providing an intellectual context for Descartes’s theory of the passions, especially by comparison with that of Tho- mas Aquinas, I examine its ‘machine psychology’, including the role of habituation and association. I contend that Descartes put forth what may reasonably be called a ‘psychology’ of the unensouled animal body and, correspondingly, of the human body when the soul does not intervene. He thus conceptually distinguished a mechanistically explicable sensory and motor psychology, common to nonhuman and human animals, from true mentality involving higher cognition and volition and requiring (in his view) an immaterial mind. (shrink)

Anton Wilhelm Amo (c. 1700 – c. 1750) – born in West Africa, enslaved, and then gifted to the Duke of Braunschweig-Wolfenbüttel – became the first African to earn a Ph.D. in philosophy at a European university. He went on to teach philosophy at the Universities of Halle and Jena. On the 16th of April, 1734, at the University of Wittenberg, he defended his dissertation, De Humanae Mentis Apatheia (On the Impassivity of the Human Mind), in which Amo investigates the (...) logical inconsistencies in René Descartes’ (1596 – 1650) res cogitans (mind) and res extensa (body) distinction and interaction by maintaining that (1) the mind does not sense material things nor does it (2) contain the faculty of sensing. (shrink)

A translation by Thomas Steele Hall, an historian of physiology, of the 1664 edition of Descartes' L'Homme (ed. Claude Clerselier). Includes an introduction, review of Descartes' physiology, a synopsis of the first French edition, bibliographical materials (editions and sources of L'Homme), and extensive interpretive notes. Also incorporates the French text of 1664 of L'Homme. Forward by I. B. Cohen.

Rene Descartes and William James had "body first" theories of the passions or emotions, according to which sensory stimulation causes a bodily response that then causes an emotion. Both held that this bodily response also causes an initial behavioral response (such as flight from a bear) without any cognitive intervention such as an "appraisal" of the object or situation. From here they differ. Descartes proposed that the initial processes that produce fear and running are entirely mechanical. Even human beings initially (...) run from the bear as a result of physiological processes alone, without mental contribution. These physiological processes also cause a mental passion, which is a cognitive representation of the situation (as regards novelty, benefit, or harm), and which motivates the will to continue the behavior already in progress. According to James, emotions are caused by instinctive bodily responses that are triggered by noncognitive but nonetheless conscious perceptual states. Emotions are bare feelings of internal physiological stirrings that accompany an instinctual response that has evolved through Darwinian natural selection. Jamesian emotions initially have no motivational or cognitive content, which they subsequently acquire through learning. The methodological legitimacy of comparing these positions across the centuries is defended, and the two theories are compared to recent theories. (shrink)

According to Kepler and Descartes, the geometry of the triangle formed by the two eyes when focused on a single point affords perception of the distance to that point. Kepler characterized the processes involved as associative learning. Descartes described the processes as a “ natural geometry.” Many interpreters have Descartes holding that perceivers calculate the distance to the focal point using angle-side-angle, calculations that are reduced to unnoticed mental habits in adult vision. This article offers a purely psychophysiological interpretation of (...) Descartes’s natural geometry. In his account of perceived limb position from the Treatise on Man, he envisioned a central brain state that controls ocular convergence and thereby co-varies with the distance from observer to object. A psychophysiological law relates the visual perception of distance to this brain state. Descartes also invokes more traditional theories of distance and size perception based on unnoticed judgments, yielding a hybrid account. (shrink)

Descartes understood the subject matter of physics (or natural philosophy) to encompass the whole of nature, including living things. It therefore comprised not only nonvital phenomena, including those we would now denominate as physical, chemical, minerological, magnetic, and atmospheric; it also extended to the world of plants and animals, including the human animal (with the exception of those aspects of the human mind that Descartes assigned to solely to thinking substance: pure intellect and will). Descartes wrote extensively on physiology and (...) on the physiology and psychology of the senses. This chapter examines the notions of *physiology* and *psychology* in medical and natural philosophical works of Descartes' day; follows his efforts to bring physiology into his mechanistic idiom; considers the relation between physiology of the animal machine and psychological functions that yield functionally appropriate behavior; goes into his physiology and psychology of vision; and elaborates the tension in Descartes' works between his metaphysically supported micro-corpuscularism and his discussion of the animal machine as an organic unity comprising various functionally and teleologically characterized systems. The chapter draws on Descartes' works in both metaphysics and natural philosophy, including his Treatise on Man (originally published as L'Homme, 1664). (shrink)

La notion de lieu occupe dans le système cartésien une place stratégique : elle en manifeste la singularité tant dans le domaine de la physique que dans celui de la métaphysique. En physique, les difficultés sont nombreuses : comment Descartes parvient-il à édifier une philosophie naturelle qui produit, notamment, les lois du choc et celle de la chute des graves, dans un cadre conceptuel qui nie l'existence du vide ainsi que celle de lieux différents? Jusqu'à quel point peut-on parler d'une (...) mathématisation du réel pour un corps de doctrine aussi peu algébrique que possible? Le spectre du roman cartésien doit être chassé afin de saisir la science cartésienne dans sa nouveauté radicale. Mais dès lors que l'on s'interroge sur les motifs conceptuels qui empêchent Descartes d'élaborer une mathématisation du réel, dont la Géométrie semble lui donner les moyens et les Regulae la méthode, on est conduit à préciser la nature des procédures résolutoires de la pensée, leur portée et leurs limites et, ainsi, à entrer de plain-pied dans le champ de la mathématique, tout d'abord, puis dans celui de la métaphysique. Dire ce qu'est et ce que peut un corps s'énonce à partir du savoir de ce qu'est et de ce que peut l'esprit. En effet, Descartes attribue à l'esprit la force et la puissance, non seulement d'inventer et de produire du nouveau, mais également celle, très concrète, d'imprimer une nouvelle détermination aux mouvements des esprits animaux. On peut considérer que la force chez Descartes est indexée au spirituel plutôt qu'au corporel et qu'en dehors de la question singulière de l'Eucharistie, elle n'est efficace qu'à la condition de ne pas être localisée stricto sensu en termes de lieu : Dieu agit dans le monde pour autant qu'il n'en fait pas partie et la glande pinéale est le siège principal de l'âme, sedes et non pas locus. Cette lecture de l'œuvre cartésienne trouve ainsi dans la notion de lieu un thème d'étude particulièrement fécond, dans la mesure où elle est mobilisée à la fois dans la physique et les mathématiques cartésiennes, mais également dans la question de la localisation de Dieu dans le monde, dans celle du Christ sous les espèces consacrées, et dans celle de l'âme dans le corps. Ainsi d'un lieu à un autre, nous sommes conduits au cœur du système cartésien, par un mouvement d'approfondissement réciproque des perspectives. (shrink)

Current theories of breast cancer progression have been greatly influenced by the development and refinement of mouse transgenic and gene targeting technologies. Early transgenic mouse models confirmed the involvement of oncogenes, previously implicated in human breast cancer, by establishing a causal relationship between overexpression or activation of these genes and mammary tumorigenesis. More recently, the importance of genes located at sites of loss of heterozygosity in human breast cancer have been examined in mice by their targeted disruption via homologous recombination. (...) The union of these two approaches allows the generation of complex animal models that more accurately reflect the multistep nature of human breast cancer. This review will examine how the study of transgenic mice has increased our understanding of the molecular events responsible for oncogenic transformation of the mammary gland. BioEssays 22:554–563, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

A large number of previous reports described an effect of the pituitary hormone prolactin (PRL) on steroid hormone production by the adrenal cortex. However, those studies remained anecdotal and were never converted into a conceptual and mechanistic framework, let alone being translated into clinical care. In the light of our recently published landmark study where we described PRL signalling as a pivotal regulator of the sexually dimorphic adrenal phenotype in mouse and of adrenal androgen production in humans, we present here (...) the overarching hypothesis that PRL signalling increases the activity of Steroidogenic Factor‐1 (SF‐1/NR5A1), a transcription factor that has an essential role in adrenal gland development and function, to regulate adrenal cortex growth and hormonal production in physiological and pathological conditions. PRL can then be considered as a bona fide adrenocorticotropic hormone synergizing with ACTH in the endocrine control of adrenal cortex function. (shrink)

Os dois ensaios aqui traduzidos: “Uma visita a uma glândula pineal”, publicado originalmente em 21 de abril de 1713 no número 35 do Guardian e a “A glândula pineal (continuação)”, publicado no dia 25 de abril, no número 39, formam uma unidade não apenas pela referência a ideia de glândula pineal concebida por Descartes como ponto de interação entre a alma e o corpo, mas também pela forma literária e pelo pseudônimo comum. Eles fazem parte de um (...) conjunto de quatorze ensaios atribuídos a George Berkeley, reunidos e publicados pela primeira vez apenas em 1871, no volume III da edição organizada por A. C. Fraser. Os ensaios publicados no Guardian foram escritos durante a permanência de Berkeley em Londres em 1713, quando Jonathan Swift (1667-1745) e Richard Steele (1672-1729), seus conterrâneos, contribuiriam para lhe abrir caminho no ambiente literário inglês. O principal objetivo de Berkeley ao publicar os ensaios foi o de defender o teísmo cristão contra os “livre-pensadores” da época, assumidos como materialistas e ateus. A tradução aqui apresentada foi realizada com base na edição organizada por Luce e Jessop. The Works of George Berkeley Bishop of Cloyne. Luce, A. A. and Jessop, T. E. London and Edimburgh: Nelson, 1948, v. 7, 185-192. (shrink)

The mammary gland is a skin gland unique to the class Mammalia. Despite a growing molecular and histological understanding of the development and physiology of the mammary gland, its functional and morphological origins have remained speculative. Numerous theories on the origin of the mammary gland and lactation exist. The purpose of the mammary gland is to provide the newborn with copious amounts of milk, a unique body fluid that has a dual role of nutrition and immunological protection. Interestingly, antimicrobial enzymes, (...) such as xanthine oxidoreductase or lysozyme, are directly involved in the evolution of the nutritional aspect of milk. We outline that xanthine oxidoreductase evolved a dual role in the mammary gland and hence provide new evidence supporting the hypothesis that the nutritional function of the milk evolved subsequent to its protective function. Therefore, we postulate that the mammary gland evolved from the innate immune system. In addition, we suggest that lactation partly evolved as an inflammatory response to tissue damage and infection, and discuss the observation that the two signaling pathways, NF‐kB and Jak/Stat, play central roles in inflammation as well as in lactation. BioEssays 28: 606–616, 2006. © 2006 Wiley Periodicals, Inc. (shrink)