Extrapolation from a well-understood base population to a less-understood target population can fail if the base and target populations are not sufficiently similar. Differences between laboratory mice and humans, for example, can hinder extrapolation in medical research. Mice that carry a partial or complete human physiological system, known as humanized mice, are supposed to make extrapolation more reliable by simulating a variety of human diseases. But what justifies our belief that these mice are similar enough to their human counterparts to (...) simulate human disease? I argue that, unless three requirements are met in the process of humanizing mice, very little does. My requirements are not meant to provide necessary and sufficient conditions that guarantee a particular outcome. Instead, they serve as a heuristic for guiding scientific judgments involving extrapolation. In developing each requirement, I engage with philosophical issues concerning the nature of model-based science and the mechanistic approach (and its limits) to making generalizations in the life sciences. (shrink)

Human–nonhuman chimeras have been the focus of ethical controversies for more than a decade, yet some related issues remain unaddressed. For example, little has been said about the relationship between the origin of transferred cells and the morally relevant capacities to which they may give rise. Consider, for example, a developing mouse fetus that receives a brain stem cell transplant from a human and another that receives a brain stem cell transplant from a dolphin. If both chimeras acquire morally relevant (...) capacities as a result of transplantation, and if those capacities are indistinguishable, should the difference in cell origin matter to how we classify these creatures? I argue that if morally relevant capacities are easy to detect, cell origin is irrelevant to how the chimera ought to be treated. However, if such capacities are hard to detect, cell origin should play a role in considerations about how to treat the chimera. (shrink)

Comparative genomicists seem to be convinced that the unit of measurement employed in their studies is a gene that drives the function of cells and ultimately organisms. As a result, they have come to some substantive conclusions about how similar humans are to other organisms based on the percentage of genetic makeup they share. I argue that the actual unit of measurement employed in the studies corresponds to a structural rather than a functional gene concept, thus rendering many of the (...) implications drawn from comparative genomic studies largely unwarranted, if not completely mistaken. †To contact the author, please write to: Department of Philosophy, University of Utah, 215 South Central Campus Drive, Carolyn Tanner Irish Humanities Building, 4th Floor, Salt Lake City, UT 84112; e‐mail: monika.piotrowska@utah.edu. (shrink)

According to Haber and Benham (2012), a sufficient condition for full moral consideration is that a creature bears a genealogical relation to the Homo sapiens lineage. Since part-humans do not bear such a relation, they are not due full moral consideration on that basis. Given this argument, my aim in this commentary is twofold. First, I want to challenge its soundness by showing that it is possible for part-humans to bear a genealogical relation to the H. sapiens lineage. Second, I (...) want to argue that Haber and Benham's attempt at avoiding moral confusion by reframing ethical concerns about part-humans doesn’t work. (shrink)

Although neurological disease and mental illness can cause terrible human suffering, strategies for researching their causes and cures are not obvious. Invasive brain research on actual human being...

Human embryo models formed from stem cells—known as embryoids—allow scientists to study the elusive first stages of human development without having to experiment on actual human embryos. But clear ethical guidelines for research involving embryoids are still lacking. Previously, a handful of researchers put forward new recommendations for embryoids, which they hope will be included in the next set of International Society for Stem Cell Research guidelines. Although these recommendations are an improvement over the default approach, they are nonetheless unworkable, (...) because they rely on a poorly conceived notion of an embryoid’s ‘potential’ to trigger stringent research regulations. (shrink)

Research ethics committees must sometimes deliberate about objects that do not fit nicely into any existing category. This is currently the case with the “gastruloid,” which is a self-assembling blob of cells that resembles a human embryo. The resemblance makes it tempting to group it with other members of that kind, and thus to ask whether gastruloids really are embryos. But fitting an ambiguous object into an existing category with well-worn pathways in research ethics, like the embryo, is only a (...) temporary fix. The bigger problem is that we no longer know what an embryo is. We haven’t had a non-absurd definition of ‘embryo’ for several decades and without a well-defined comparison class, asking whether gastruloids belong to the morally relevant class of things we call embryos is to ask a question without an answer. What’s the alternative? A better approach needs to avoid what I’ll refer to as “the potentiality trap” and, instead, rely on the emergence of morally salient facts about gastruloids and other synthetic embryos. (shrink)

What’s the basis for considering an egg donor a genetic parent but not a mitochondrial donor? I will argue that a closer look at the biological facts will not give us an answer to this question because the process by which one becomes a genetic parent, i.e., the process of reproduction, is not a concept that can be settled by looking. It is, rather, a concept in need of philosophical attention. The details of my argument will rest on recent developments (...) in biological technology, but the persuasiveness of my argument will turn on the history of another biological concept, death. Given some important similarities between the two concepts, the way in which ‘death’ evolved in the recent past can provide guidance on how we should think about ‘reproduction.’. (shrink)

Media reporters often announce that we are on the verge of bringing back the woolly mammoth, even while there is growing consensus among scientists that resurrecting the mammoth is unlikely. In fact, current “de-extinction” efforts are not designed to bring back a mammoth, but rather adaptations of the mammoth using close relatives. For example, Harvard scientists are working on creating an Asian elephant with the thick coat of a mammoth by merging mammoth and elephant DNA. But how should such creatures (...) be classified? Are they elephants, mammoths, or both? Answering these questions requires getting clear about the concept of reproduction. What I hope to show is that with an appropriate notion of reproduction—one for which I will argue—resurrecting a member of Mammuthus primigenius is a genuine possibility. (shrink)

I begin with a description of the benefits and limits of DNA barcoding as presented by its advocates not its critics. Next, I argue that due to the mutually dependent relationship between defining and delimiting species, all systems of classification are grounded in theory, even if only implicitly. I then proceed to evaluate DNA barcoding in that context. In particular, I focus on the barcoders’ use of a sharp boundary by which to delimit species, arguing that this boundary brings along (...) additional theoretical commitments inconsistent with the way taxonomists conceive of species, viz., as entities that have vague boundaries and that cannot be defined by any single attribute other than ancestry. Given these inconsistencies, I conclude that even if groupings based on DNA barcodes match those of an existing taxonomy, the two systems of classification are not necessarily tracking the same entities, i.e., species. (shrink)

With an increasing number of ways to ‘assist’ reproduction, some bioethicists have started to wonder what it takes to become a genetic parent. It is widely agreed that sharing genes is not enough to substantiate the parent–offspring relation, but what is? Without a better understanding of the concept of reproduction, our thinking about parent–offspring relations and the ethical issues surrounding them risk being unprincipled. Here, I address that problem by offering a principled account of reproduction—the Overlap, Development and Persistence account—which (...) I believe best captures the meaning of ‘genetic parenthood’. (shrink)

Depression is a widespread and debilitating disorder, but developing effective treatments has proven challenging. Despite success in animal models, many treatments fail in human trials. While various factors contribute to this translational failure, standardization practices in animal research are often overlooked. This paper argues that certain standardization choices in behavioral neuroscience research on depression can limit the generalizability of results from rodents to humans. This raises ethical and scientific concerns, including animal waste and a lack of progress in treating human (...) patients. To address these issues, animal ethics committees can establish reasonable expectations for preclinical research and highlight the impact of standardization on generalizability. Such efforts can help improve translation from animal models to human patients and ultimately benefit those suffering from depression. (shrink)

I am grateful to the authors who commented on my article (Piotrowska 2014) for their careful examination of my argument. They have presented a variety of stimulating ideas and suggestions, with which I largely agree and which I would like to discuss further, but in the interest of brevity, I shall try to concentrate only on points of contention.

New discoveries are improving the odds of human cells surviving in host animals, prompting regulatory and funding agencies to issue calls for additional layers of ethical oversight for certain types of human–animal chimeras. Of interest are research proposals involving chimeric animals with humanized brains. But what is motivating the demand for additional oversight? I locate two, not obviously compatible, motivations, each of which provides the justificatory basis for paying special attention to different sets of human–animal chimeras. Surprisingly, the sets of (...) animals that actually get flagged for special scrutiny by research and funding guidelines do not correlate with either of the sets of animals that arise when we think about what is motivating additional oversight. What this shows is that existing research policies and funding guidelines are disconnected from their motivation: the rationale for flagging certain types of human–animal chimeras as requiring special oversight is ignored in execution. (shrink)

The book is divided into four sections, and contains two central arguments. The goal of the first argument is to show that generally accepted concepts in moral theory have an irreducibly second-personal character and that it is impossible to fully understand many central moral ideas without it. Here, by evaluating a broad range of literature in moral theory and articulating the second-personal aspect of each, Darwall elaborates on the interpersonal nature of moral obligation. The detailed discussion presents some well-known moral (...) theories, and while emphasizing the Deontological perspective, highlights the second-personal character of all moral theories; a perspective that has, in the past, gone unnoticed. However, as Darwall himself acknowledges, the first argument cannot vindicate the very ideas it analyzes. He thus dedicates the second part of the book to a reverse-strategy: instead of arguing for the existence of a second-person foundation in moral theory, Darwall sets out to show that the presuppositions of the second-person standpoint include the moral law in them. In this second argument, Darwall explains that the second-personal standing can only be justified within a circle of four interrelated ideas (claim, accountability, second-personal reason, and second-personal authority), and that this circle necessarily excludes instances of coercion. (shrink)

Much of the book is aimed at persuading the reader that genes are not ‘the prime movers in all biological processes’ and that ‘postgenomic genes’ are better understood in a functional sense, as ‘things an organism can do with its genome.' With the main argument in place, the authors examine its impact on a number of philosophical debates. I will discuss three of them: causation, information, and reduction.

This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...) interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human‐nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics’ previous focus on human‐centered questions about the ethics of “humanization” and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less‐siloed governance and oversight and more‐comprehensive public communication. (shrink)

Unfounded—conspiracy and health—beliefs about COVID-19 have accompanied the pandemic worldwide. Here, we examined cross-nationally the structure and correlates of these beliefs with an 8-item scale, using a multigroup confirmatory factor analysis. We obtained a two-factor model of unfounded (conspiracy and health) beliefs with good internal structure (average CFI = 0.98, RMSEA = 0.05, SRMR = 0.04), but a high correlation between the two factors (average latent factor correlation = 0.57). This model was replicable across 50 countries (total N = 13,579), (...) as evidenced by metric invariance between countries (CFI = 0.96, RMSEA = 0.06, SRMS = 0.07) as well as scalar invariance across genders (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03) and educational levels (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03). Also, lower levels of education, more fear of COVID-19, and more cynicism were weakly associated with stronger conspiracy and health beliefs. The study contributes to knowledge about the structure of unfounded beliefs, and reveals the potential relevance of affective (i.e., fear of COVID-19) and cognitive (i.e., cynicism) factors along with demographics, in endorsing such beliefs. In summary, we obtained cross-cultural evidence for the distinctiveness of unfounded conspiracy and health beliefs about COVID-19 in terms of their structure and correlates. (shrink)

Monika Piotrowska has defended a new account of reproduction. Her account seems able to answer the question of whether reproduction takes place, and who reproduces, when we employ biotechnologies that bear little to no resemblance to naturally occurring human sexual reproduction. Piotrowska's account also seems to increase our understanding of biological individuality and seems to be compatible with the theory of evolution via natural selection. In this paper, I do two things. First, I show that Piotrowska's (...) account is found wanting, because it is extensionally inadequate. Second, I show that her criticism of James Grisemer's account of reproduction is mistaken. (shrink)

I respond to Monika Piotrowska's argument against anthropocentric theories of moral status that they yield disparate moral verdicts about parallel cases of embryonic stem cell transplantation. I argue that anthropocentric theories of moral status may not fall prey to this problem because embryonic stem cell transplantation may constitute creation rather than mere enhancement.

Previous research examining the relationship between religion and attitudes about death have yielded mixed results due to over-simplified conceptualizations of constructs, lack of theory, and an over-reliance on Western samples. To overcome these issues, the present study examined the relationship between three types of religious orientation and two types of death attitudes among a sample of 532 college students in Poland. The results demonstrated unique relations between religion and death attitudes, as well emphasized the importance of considering religious engagement as (...) a moderating variable. Although the results were generally consistent with Terror Management Theory, other theoretical perspectives were considered as well. (shrink)

This distinctively interdisciplinary approach to the subject encompasses filmmaking, psychoanalysis, philosophy and popular culture and offers a unique insight into documentary film practice from a psychoanalytic perspective. At the heart of the enquiry is belief that ‘transference-love’ is present in the documentary encounter. With a focus on testimony-driven film and a foreword by Michael Renov, who calls this book 'a radical and compelling account', _Psychoanalysis and Ethics in Documentary Film _covers a range of topics including: Four fundamental concepts of psychoanalysis (...) and documentary film A review of documentary film practice A personal account of the author’s relationship with a subject of her own work A thorough interrogation of the ethics of documentary Ideal for film studies scholars, psychoanalysts, psychotherapists and psychotherapeutically engaged professionals, as well as filmmakers, culture studies students and anyone interested in the process of documentary-making and contemporary culture, this work offers a unique approach. (shrink)

This article focuses stakeholder theory on that critical juncture where stakeholder relationships and corporate policy decisions converge. A case study methodology is described that permits detailed analyses of multiple stakeholders’ objectives; it is suitable for studies of major corporate strategic decisions that are complex, controversial, involve multiple stakeholders, and require strategic trade-offs. The methodology is applied here to the dramatic decision by a Pacific Northwest forest company to phase out traditional clear-cut harvesting methods of old-growth forests. The study’s findings point (...) to new research questions and have theoretical implications for a finer grained conceptualization of stakeholder groups, stakeholder objectives, and stakeholder issues. (shrink)

The current study investigated age differences in the use of attentional deployment, positive reappraisal and suppression while regulating responses to sadness-eliciting content. We also tested to what extent these emotion regulation strategies were useful for each age group in managing response to age-relevant sad information. Forty-two young participants (Mage = 18.5, SE =.15) and 48 older participants (Mage = 71.42, SE = 1.15) watched four sadness-eliciting videos (about death/illness, four to five minutes long) under four conditions—no-regulation (no regulation instructions), attentional (...) deployment (divert attention away), positive reappraisal (focus on positive outcomes) and suppression (conceal emotional expressions). We assessed negative emotional experience, expression, skin conductance level (SCL) and visual fixation duration while participants watched the emotional clips and followed the instructions for each condition. Results suggest that older adults were more successful than younger adults at implementing both attentional deployment and positive reappraisal. Ability to suppress emotions appears to remain stable with age. Within age-group comparisons suggested that for the older adults, positive reappraisal was a more useful emotion regulation strategy than the others, while the pattern among younger adults was less conclusive. Age-relevant differences in motivation and successful emotion regulatory efforts based on theoretical and empirical literatures are discussed. (shrink)

The article focuses on Enoch Powell’s “Rivers of Blood” speech and its recontextualisation 50 years later in view of the rising anti-immigration sentiment and Brexit campaign. Having discussed the dynamics of the threat construction process and its role in shaping public attitudes to migration and policies related to it across time and space, we proceed to analyse Powell’s speech in terms of lexical, grammatical, and discursive fear-inciting devices and strategies. While doing so we draw on the insights from neuroscientific research (...) on the role of lexis in fear stimulation and functional-cognitive models of grammatical structure. The second part of our analysis is meant to demonstrate how the semiotic potential of cyberspace and social media, along with multimodal integration of various forms, intertextuality, and interdiscursivity they enable, endow fear-inciting discourse with new spatiotemporal and affective qualities. To this end we examine one of the most popular YouTube videos making “Rivers of Blood” speech part of its anti-immigration stance. (shrink)

The development of the modern democratic society depends upon the successful integration of main democratic values in all its spheres, including education. Schools are faced with these challenges as well. The main role in the process of school change is given to the school principal, who is the leader of every innovation in school. One out of many types of school leadership is called democratic school leadership. One of the goals of such leadership is the development of school culture that (...) is based on democratic values and practices. Further on, the development of democratic school leadership opens an opportunity for students and teachers to gain knowledge an develop skills needed for them to become active citizens in their communities. The main purpose of this paper is to analyze the existing literature in the field of democratic school leadership. Special focus is on the theoretical and practical operationalization of the democratic school leadership as it is presented the literature. Further, we shall analyze the possible answers to the questions of why and how to develop the democratic school leadership, and what is its role in the development of the democratic school community. (shrink)

Building on the cultural transfer theory of Michel Espagne and Michael Werner, the paper examines the history of Marian Zdziechowski’s interactions with Leo Tolstoy. Its starting point is their correspondence of the 1890s, and the endpoint – Zdziechowski’s magnum opus Pessimism, Romanticism and the Bases of Christianity (1915). The main emphasis lies on two microhistories of cultural transfer with opposing vectors, represented in the relations between these two figures. The first, revolving around the publication of Zdziechowski’s essay Religious and Political (...) Ideals of Polish Society, is dedicated to the attempts of Zdziechowski, a young Polish intellectual, to secure a place in the field of Russian intellectual culture with the help of Tolstoy, one of its leading figures. The second concentrates on Tolstoy’s letter to Zdziechowski, which the latter used as a preface to a separate publication of his essay. Aiming to communicate the idea that Tolstoy was no enemy for the Poles to the Polish audience, Zdziechowski thus responded to the critical reaction to Tolstoy in the Polish press of the Austro-Hungarian Empire. In the end, the figure of Zdziechowski as a mediator between cultural fields proves to be of high value for further studies of processes and mechanisms of cultural transfer. (shrink)

This book is the first presentation in Polish scientific literature of the views and concepts of social constructivists on the complex and varied problems of the philosophy of science with particular consideration of mathematics. It is based on numerous publications and comments of the founders and supporters of social constructivism.

In 1905 was publshed a biographical nowel written by Adolf Nowaczyński entitled Portrait of Mikołaj Rej from Nagłowice. While the novel was being written, there were not enough comprehensive and reliable materials about Rej’s life. The purpose of this work is to show pieces of work which were used by Nowaczyński in his novel. Only thanks to searching analysis of those hypothetical available materials the author could manage to establish sources of the hero’s creation. We are sure to say that (...) while writing a novel about Rej, Nowaczyński took some pieces information from Andrzej Trzecieski’s biograhy from the XVI century and Zbigniew n‘aziohtcki’s biography from the XIX century. We can suppose that the author of the Crcation knew the results of Beicikowski’s research. (shrink)

Our daily lives unfold continuously, yet our memories are organised into distinct events, situated in a specific context of space and time, and chunked when this context changes (at event boundaries). Previous research showed that this process, termed event segmentation, enhances object-context binding but impairs temporal order memory. Physiologically, peaks in pupil dilation index event segmentation, similar to emotion-induced bursts of autonomic arousal. Emotional arousal also modulates object-context binding and temporal order memory. Yet, these two critical factors have not been (...) systematically studied together. To address this gap, we ran a behavioural experiment using a paradigm validated to study event segmentation and extended it with emotion manipulation. During encoding, we sequentially presented greyscale objects embedded in coloured frames (colour changes defining events), with a neutral or aversive sound. During retrieval, we tested participants’ memory of temporal order memory and object-colour binding. We found opposite effects of emotion and event segmentation on episodic memory. While event segmentation enhanced object-context binding, emotion impaired it. On the contrary, event segmentation impaired temporal order memory, but emotion enhanced it. These findings increase our understanding of episodic memory organisation in laboratory settings, and potentially in real life with perceptual changes and emotion fluctuations constantly interacting. (shrink)

This article generalises the refined A-translation method for extracting programs from classical proofs [U. Berger,W. Buchholz, H. Schwichtenberg, Refined program extraction from classical proofs, Annals of Pure and Applied Logic 114 3–25] to the scenario where additional assumptions such as choice principles are involved. In the case of choice principles, this is done by adding computational content to the ‘translated’ assumptions, an idea which goes back to [S. Berardi, M. Bezem, T. Coquand, On the computational content of the axiom of (...) choice, JSL 63 600–622] and has been further elaborated in [U. Berger, P. Oliva, Modified bar recursion and classical dependent choice, in: M. Baaz, S.D. Friedman, J. Kraijcek , Logic Colloquium ’01, in: Lecture Notes in Logic, vol. 20, Springer, Berlin, 2005, pp. 89–107]. We further investigate the applicability of this extension by means of a small but non-trivial example, and discuss the formalisation as well as some optimisations necessary in order to extract terminating programs. Both formalisation and term extraction have been implemented in the interactive proof assistant Minlog. (shrink)

What is the nature and what is the role of trust between teacher and student in academic education at school? Providing a philosophically informed answer to these questions is the aim of this paper. In its first part, I present a relationship account of trust based on two fundamental assumptions: first, trust between teacher and student is essentially about them being in a trust relationship, and second, the reasons for trust are relationship dependent. The second part explores the role of (...) trust by looking at two aspects of academic education at school: the student's acquisition of knowledge from the teacher's testimony and the student's development of epistemic confidence, the latter being a key constituent of competent epistemic agency. Drawing on findings from developmental psychology, I explain how trust is involved in successful academic education at school. My aim is to provide a detailed conception of trust in the teacher–student relationship, as well as a conclusive argument for the importance and the value of trust in academic education at school. (shrink)