In this chapter we offer a critical analysis of organizational models about the process of origins of life and, thereby, a reflection about life itself (understood in a general, minimal sense). We begin by demarcating the idea of organization as an explanatory construct, linking it to the complex relationships and transformations that the material parts of (proto-)biological systems establish to maintain themselves under non-equilibrium dynamic conditions. The diverse ways in which this basic idea has been applied within the prebiotic (...) field are then reviewed in relative detail. We distinguish between “network” and “protocell” approaches, discussing their specific implications and explaining the greater relevance of the latter in the current state of affairs. Despite the key role that such organizational approaches play (and should keep playing) to advance on the problem of primordial biogenesis, the second half of our contribution is devoted to argue that they must be combined with other explanatory accounts, which go beyond the physiology of any single (proto-)organism. With that aim, we underline the fundamental differences between the autonomous, metabolic dynamics that individual (proto-)cells perform and the evolutionary and ecological dynamics that take place in a collective and trans-generational dimension. Apart from obvious gaps in the characteristic temporal and spatial scales involved, the corresponding causal and interactive regimes also reveal themselves as neatly distinct, what is reflected in the unpaired functional integration and the agent behavior displayed by biological individuals. Nevertheless, any living organism (and life in a wider, general sense) derives from the deep interweaving of those two phenomenological domains: namely, the “individual-metabolic” and the “collective-evolutionary” domains. At the end of the chapter, we propose the principle of dynamical decoupling as the core idea to develop a more comprehensive theoretical framework to understand how this intricate, causally asymmetric connection must be articulated during the actual process of biogenesis (as it happened here on Earth or anywhere else in the universe), so that life’s minimal complexity threshold is reached. (shrink)

The term biology is of Greek origin meaning the study of life. On the other hand, chemistry is the science of matter, which deals with matter and its properties, structure, composition, behavior, reactions, interactions and the changes it undergoes. The theory of abiogenesis maintains that chemistry made a transition to biology in a primordial soup. To keep the naturalistic ‘inanimate molecules to human life’ evolution ideology intact, scientists must assemble billions of links to bridge the gap between the (...) inanimate chemicals that existed in the primordial soup and anatomically modern humans. Even though the proponents of a natural origin of life expressed much optimism for providing their theories, presently there is a detailed compilation of information seriously questioning this doctrine. This reductionistic ideology has always failed to answer two simple questions: (1) What is the minimum number of parts that are essential for a living organism to survive? (2) By what mechanism do these parts get assembled together? Evolutionists say a series of prebiotic processes and developments guide networks of dynamically linked small molecules and amphiphiles to form biological macromolecules, membraneous compartments, and finally primitive cells. However, none of these proposed pathways to life appears to be credible. The continuous advancement in various fields of science are not only providing major challenges to reductionistic ideology but are supplying increasing evidence for a systemic concept of life as an organic whole. Several leading researchers in the field of ‘origin of life’ are continually concluding that there are major scientific problems attached with all existing naturalistic ‘origin of life’ hypothesis. Only by taking into account all biological activities collectively as a system can a satisfactory elucidation of the living state be realized. In this present paper an attempt has been made to present a few significant challenges to the theory of abiogenesis based on the peer reviewed scientific literature. Subsequently, a non-reductionistic concept of life as a system is proposed as an alternative for resolving some of the problems inherent in origin of life research. (shrink)

The Oparin hypothesis from 1936 was a milestone in the origin of life research, making a model that was at least in part empirically testable, and changing the course of life studies from a long tradition of metaphysics to a scientific domain of investigation. His hypothesis is based on the idea of the prebiotic synthesis of macromolecules as a fundamental step on the road to first life. Although the Oparin hypothesis brought fresh ideas and concepts, in its description of (...) the steps in the hypothesized transition from the inorganic to the organic world in detail, today some premises are considered unconfirmed, uncertain, or even rejected. With high respect to its metatheoretical reach and scientific impact on prebiotic chemistry, pushing the origin of first life research into an empirical context, from a contemporary viewpoint, its contribution is highly limited in the area of history of science and history of philosophy (of science). Keywords: biology, history of science, Oparin, origin of life, philosophy of science. (shrink)

Emmanuel Davoust, an internationally known specialist on galaxies, explores such major themes and topics of debate as prebiotic chemistry and paleovisits, in this lucid investigation of the continuing search for extraterrestrial life.

Philosophers of science have variously tried to characterize how-possibly explanations (HPEs) and distinguish them from how-actually explanations (HAEs). I argue that existing contributions to this debate have failed to pay attention to the different, but complementary, functions possibilities play in scientific explanations. To bring these functions to the fore, I introduce a distinction between what I call elucidating and embedding HPEs. While elucidating HPEs specify and demonstrate possible processes for a given research target, embedding HPEs demonstrate how the research target (...) fits into a space of suitably constrained possibilities. I specify both functions of HPE with reference to two case studies from origins-of-life research. I contrast my distinction with an alternative proposal by Wirling and Grüne-Yanoff (2024) to highlight that focusing on the functions, rather than types, of possibilities in explanation is better suited to account for key scientific practices. (shrink)

The systems view on life and its emergence from complex chemistry has remarkably increased the scientific attention on metabolism in the last two decades. However, during this time there has not been much theoretical discussion on what constitutes a metabolism and what role it actually played in biogenesis. A critical and updated review on the topic is here offered, including some references to classical models from last century, but focusing more on current and future research. Metabolism is considered as (...) intrinsically related to the living but not necessarily equivalent to it. More precisely, the idea of “minimal metabolism”, in contrast to previous, top‐down conceptions, is formulated as a heuristic construct, halfway between chemistry and biology. Thus, rather than providing a complete or final characterization of metabolism, our aim is to encourage further investigations on it, particularly in the context of life's origin, for which some concrete methodological suggestions are provided. Also see the video abstract here:https://youtu.be/DP7VMKk2qpA. (shrink)

A simple molecular system is described consisting of the reciprocal linkage between an autocatalytic cycle and a self-assembling encapsulation process where the molecular constituents for the capsule are products of the autocatalysis. In a molecular environment sufficiently rich in the substrates, capsule growth will also occur with high predictability. Growth to closure will be most probable in the vicinity of the most prolific autocatalysis and will thus tend to spontaneously enclose supportive catalysts within the capsule interior. If subsequently disrupted in (...) the presence of new substrates, the released components will initiate production of additional catalytic and capsule components that will spontaneously re-assemble into one or more autocell replicas, thereby reconstituting and sometimes reproducing the original. In a diverse molecular environment, cycles of disruption and enclosure will cause auto-cells to incidentally encapsulate other molecules as well as reactive substrates. To the extent that any captured molecule can be incorporated into the autocatalytic process by virtue of structural degeneracy of the catalytic binding sites, the altered autocell will incorporate the new type of component into subsequent replications. Such altered autocells will be progenitors of “lineages” with variant characteristics that will differentially propagate with respect to the availability of commonly required substrates. Autocells are susceptible to a limited form of evolution, capable of leading to more efficient, more environmentally fitted, and more complex forms. This provides a simple demonstration of the plausibility of open-ended reproduction and evolvability without self-replicating template molecules or maintenance of persistent nonequilibrium chemistry. This model identifies an intermediate domain between prebiotic and biotic systems and bridges the gap from nonequilibrium thermodynamics to life. (shrink)

One of the most influential physics books of the twentieth century was actually about biology. In a series of lectures, Erwin Schrödinger described how he believed that quantum mechanics, or some variant of it, would soon solve the riddle of life. These lectures were published in 1944 under the title What is life? and are credited by some as ushering in the age of molecular biology. In the nineteenth century, many scientists thought they knew the answer to Schrödinger’s rhetorical question. (...) Life, they maintained, was some sort of magic matter. The continued use of the term ‘organic chemistry’ is a hangover from that era. The belief that there is a chemical recipe for life led to the hope that, if only we knew what it was, we could mix up the right stuff in a test tube and make life in the lab. Most research on biogenesis has followed that tradition, by assuming that chemistry was a bridge — and a long one at that — linking matter with life. Elucidating this chemical pathway has been a tantalizing goal, spurred on by the famous Miller–Urey experiment of 1952, in which amino acids were made by sparking electricity through a mixture of water and common gases. But the concept has turned out to be something of a blind alley, and further progress with prebiotic chemical synthesis has been frustratingly slow. The origin of life remains one of the great outstanding mysteries of science. To take up Schrödinger’s suggestion, a radical solution to the problem, ‘What is life?’ could be that quantum mechanics enabled life to emerge directly from the atomic world, without the need for complex intermediate chemistry. Life must have a chemical basis: organic molecules provide the hardware for biology. But what about the software? When Schrödinger asked, ‘What is life?’ he could already glimpse the central significance of the cell’s information storage and replication processes, even though the role of DNA and the genetic code was yet to be discovered.. (shrink)

This paper calls attention to a philosophical presupposition, coined here the continuity thesis which underlies and unites the different, often conflicting, hypotheses in the origin of life field. This presupposition, a necessary condition for any scientific investigation of the origin of life problem, has two components. First, it contends that there is no unbridgeable gap between inorganic matter and life. Second, it regards the emergence of life as a highly probable process. Examining several current origin-of-life theories. I indicate the implicit (...) or explicit role played by the continuity thesis in each of them. In addition, I identify the rivals of the thesis within the scientific community — the almost miracle camp. Though adopting the anti-vitalistic aspect of the continuity thesis, this camp regards the emergence of life as involving highly improbable events. Since it seems that the chemistry of the prebiotic stages and of molecular self-organization processes rules out the possibility that life is the result of a happy accident, I claim that the almost miracle view implies in fact, a creationist position. (shrink)

The central dogma of molecular biology dictates that, with only a few exceptions, information proceeds from DNA to protein through an RNA intermediate. Examining the enigmatic steps from prebiotic to biological chemistry, we take another road suggesting that primordial peptides acted as template for the self-assembly of the first nucleic acids polymers. Arguing in favour of a sort of archaic “reverse translation” from proteins to RNA, our basic premise is a Hadean Earth where key biomolecules such as amino (...) acids, polypeptides, purines, pyrimidines, nucleosides and nucleotides were available under different prebiotically plausible conditions, including meteorites delivery, shallow ponds and hydrothermal vents scenarios. Supporting a protein-first scenario alternative to the RNA world hypothesis, we propose the primeval occurrence of short two-dimensional peptides termed “selective amino acid- and nucleotide-matching oligopeptides” (henceforward SANMAOs) that noncovalently bind at the same time the polymerized amino acids and the single nucleotides dispersed in the prebiotic milieu. In this theoretical paper, we describe the chemical features of this hypothetical oligopeptide, its biological plausibility and its virtues from an evolutionary perspective. We provide a theoretical example of SANMAO’s selective pairing between amino acids and nucleosides, simulating a poly-Glycine peptide that acts as a template to build a purinic chain corresponding to the glycine’s extant triplet codon GGG. Further, we discuss how SANMAO might have endorsed the formation of low-fidelity RNA’s polymerized strains, well before the appearance of the accurate genetic material’s transmission ensured by the current translation apparatus. (shrink)

Darwin’s main contribution to modern biology was to make clear that all history of life on earth is dominated by a simple principle, which is usually summarised as 'descent with modification'. However, interpretations about how this modification is produced have been controversial. In light of the data provided by recent studies on molecular biology, developmental biology, genomics, and other biological disciplines we discuss, in this paper, how Darwin's theory may apply to two main 'types' of evolution: that occurring in the (...) prebiotic world and that regarding the acquisition of major key-innovations differentiating higher-taxa, which makes up part of the so-called macroevolution. We argue that these studies show that evolution is a fascinating, complex and multifaceted process, with different mechanisms drivin it on different occasions and in different places. (shrink)

This book reflects on the significant and highly original scientific contributions of Hans Primas. A professor of chemistry at ETH Zurich from 1962 to 1995, Primas continued his research activities until his death in 2014. Over these 50 years and more, he worked on the foundations of nuclear magnetic resonance spectroscopy, contributed to a number of significant issues in theoretical chemistry, helped to clarify central topics in quantum theory and the philosophy of physics, suggested innovative ways of addressing (...) interlevel relations in the philosophy of science, and introduced cutting-edge approaches in the flourishing young field of scientific studies of consciousness. His work in these areas of research and its continuing impact is described by noted experts, colleagues, and collaborators of Primas. All authors contextualize their contributions to facilitate the mutual dialog between these fields. (shrink)

Chemistry and physics are two sciences that are hard to connect. Yet there is significant overlap in their aims, methods, and theoretical approaches. In this book, the reduction of chemistry to physics is defended from the viewpoint of a naturalised Nagelian reduction, which is based on a close reading of Nagel's original text. This naturalised notion of reduction is capable of characterising the inter-theory relationships between theories of chemistry and theories of physics. The reconsideration of reduction also (...) leads to a new characterisation of chemical theories. This book is primarily aimed at philosophers of chemistry and chemists with an interest in philosophy, but is also of interest to the general philosopher of science. (shrink)

We hypothesize that life began not with the first self‐reproducing molecule or metabolic network, but as a prebiotic ecology of co‐evolving populations of macromolecular aggregates (composomes). Each composome species had a particular molecular composition resulting from molecular complementarity among environmentally available prebiotic compounds. Natural selection acted on composomal species that varied in properties and functions such as stability, catalysis, fission, fusion and selective accumulation of molecules from solution. Fission permitted molecular replication based on composition rather than linear structure, (...) while fusion created composomal variability. Catalytic functions provided additional chemical novelty resulting eventually in autocatalytic and mutually catalytic networks within composomal species. Composomal autocatalysis and interdependence allowed the Darwinian co‐evolution of content and control (metabolism). The existence of chemical interfaces within complex composomes created linear templates upon which self‐reproducing molecules (such as RNA) could be synthesized, permitting the evolution of informational replication by molecular templating. Mathematical and experimental tests are proposed. BioEssays 28: 399–412, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Crossing the boundaries - between nature and artifact and between inanimate and living matter - is a major feature of the convergence between nanotechnology and biotechnology. This paper points to two symmetric ways of crossing the boundaries: chemists mimicking nature's structures and processes, and synthetic biologists mimicking synthetic chemists with biological materials. However to what extent are they symmetrical and do they converge toward a common view of life and machines? The question is addressed in a historical perspective. Both biomimetic (...) chemistry and synthetic biology can be described as descendants of an ambitious program developed by Stéphane Leduc who coined the phrase 'synthetic biology' in the early twentieth century. The main intention of this genealogy is to emphasize that although making life in a test tube is a recurrent project there are subtle nuances in the underlying metaphysical assumptions. This comparison is meant to contribute to a better understanding of the cultural issues at stake in the convergence between nano and biotechnologies. It suggests that the demarcation line between life and inanimate matter remains a hot issue, and that all traffics across the borders do not proceed from the same metaphysical assumptions. (shrink)

Using the Public Value Mapping framework, I address the values successes and failures of chemistry as compared to the emerging field of green chemistry, in which the promoters attempt to incorporate new and expanded values, such as health, safety, and environmental sustainability, to the processes of prioritizing and conducting chemistry research. I document how such values are becoming increasingly public. Moreover, analysis of the relations among the multiple values associated with green chemistry displays a greater internal (...) coherence and logic than for conventional chemistry. Although traditional chemistry research has successfully contributed to both economic and values gains, there have been public values failures due to imperfect values articulations, failure to take a longer-term view, and inertia within a system that places too much emphasis on science values. Green chemistry, if implemented effectively, has potential to remedy these failures. (shrink)

Chemistry laboratories, as buildings, have been surprisingly little studied by historians of science; interest has been focused on them more as sites of specific scientific activity, with particular emphasis on the personalities who worked within them. This has overshadowed aspects of laboratories such as their specification, design, construction, fitting-out, adaptation, replacement, status as civic and academic structures, and so on. Systematic study of them would be aided by an agreed taxonomy of laboratory types, according to their purpose, and a (...) scheme is proposed here. Practically no pre-1800 chemical laboratories survive, and there are very few dating from earlier than 1900, at least in their original state. Encouragingly, there have been several recent archaeological excavations which have turned up interesting evidence of early examples from various cultures. Little interest has been shown in the preservation of laboratories as significant architectural or historical structures, certainly when compared with other building types. The paper closes by considering those English laboratories which enjoy some level of legal protection but questioning the criteria adopted in deciding the programme of preservation. (shrink)

Chemistry and dynamics are closely related in G.W. Leibniz's thinking, from the corpuscularism of his youth to the theory of conspiracy movements that he proposes in his later years. Despite the importance of chemistry and chemical thought in Leibniz's philosophy, interpreters have not paid enough attention to this subject, especially in the recent decades. This work aims to contribute to filling this gap in Leibnizian studies. In this first part of the work I will expose the theory of (...) matter that the young Leibniz conceives under the influence of chemical corpuscularism. Leibniz uses R. Boyle's interpretation of the Aristotelian idea of form in order to give an explanation of the unity and cohesion of bodies. As opposed to the Cartesians, Leibniz puts forth the idea of a dependence between the variables of extension, movement and figure, without losing analytical clarity and with the aim of extending the explanatory power of physics to natural phenomena difficult to approach by Cartesian mechanics. (shrink)

In this paper we wish to raise the following question: which conceptual obstacles need to be overcome to arrive at a scientific and theoretical understanding of the mind? In the course of this examination, we shall encounter methodological and explanatory challenges and discuss them from the point of view of the philosophy of chemistry and quantum mechanics. This will eventually lead us to a discussion of emergence and metaphysics, thereby focusing on the status of objects. The question remains whether (...) this could be interpreted in terms of a re-description or dissolution of seemingly troubling problems in the philosophy of mind, or whether it further emphasizes the problematic: the ubiquitous and irreducible role of mind and consciousness in scientific activities. (shrink)

This article examines how chemists contributed to the technological reorganization in France at the end of the eighteenth century and the beginning of the nineteenth century, how they justified using potentially harmful or polluting processes by stating that this would contribute to national prosperity, and how the idea of improvement helped to legally and rhetorically build a production regime that disqualified traditional precautionary attitudes to certain artisanal and industrial processes. This resulted in the establishment of a new environmental governance regime (...) devoted to the advancement of chemistry and of industrial production. While this shift was clearly perceptible from the 1770s with the first regulatory exceptions for strategic products, the 1810 decree, which was imagined, designed, and implemented by chemists, perpetuated chemistry’s role as an environmental regulator. (shrink)

Even the simplest cell exhibits a high degree of functional differentiation (FD) realized through several mechanisms and devices contributing differently to its maintenance. Searching for the origin of FD, we briefly argue that the emergence of the respective organizational complexity cannot be the result of either natural selection (NS) or solely of the dynamics of simple self-maintaining (SM) systems. Accordingly, a highly gradual and cumulative process should have been necessary for the transition from either simple self-assembled or self-maintaining systems of (...) functionless structural components to systems with FD. We follow results of recent in vitro experiments with respect to competition among protocells, where a primitive type of selection begins to operate among them accompanied by a parallel evolution of their functional domain. We argue that minimal forms of FD should be established within the evolution of SM processes in protocells as they undergo a simpler selection process for stability and persistence in a prebiotic environment. We then suggest the concept of closure of constraints (CoC) as a way to identify and describe minimal FD in a far-from-equilibrium SM organization. We show in detail how the concept of CoC together with the conditions for its fulfillment can be applied in the case of a simple protocellular system that begins to couple internal chemical reactions with the formation of its membrane components. Finally, we discuss how such SM systems can evolve towards significantly higher levels of FD, suggesting this is mainly the result of functional recombination (formation of mechanisms) in the context of a modular SM organization. (shrink)

In 1931 eminent chemist Fritz Paneth maintained that the modern notion of “element” is closely related to (and as “metaphysical” as) the concept of element used by the ancients (e.g., Aristotle). On that basis, the element chlorine (properly so-called) is not the elementary substance dichlorine, but rather chlorine as it is in carbon tetrachloride. The fact that pure chemicals are called “substances” in English (and closely related words are so used in other European languages) derives from philosophical compromises made by (...) grammarians in the late Roman Empire (particularly Priscian [fl. ~520 CE]). When the main features of the constitution of isotopes became clear in the first half of the twentieth century, the formal (IUPAC) definition of a “chemical element” was changed. The features that are “essential” to being an element had previously been “transcendental” (“beyond the sphere of consciousness”) but, by the mid-twentieth century the defining characteristics of elements, as such, had come to be understood in detail. This amounts to a shift in a “horizon of invisibility” brought about by progress in chemistry and related sciences. Similarly, chemical insight is relevant to currently-open philosophical problems, such as the status of “the bundle theory” of the coherence of properties in concrete individuals. (shrink)

It is often assumed that chemistry was a typical positivistic science as long as chemists used atomic and molecular models as mere fictions and denied any concern with their real existence. Even when they use notions such as molecular orbitals chemists do not reify them and often claim that they are mere models or instrumental artefacts. However a glimpse on the history of chemistry in the longue durée suggests that such denials of the ontological status of chemical entities (...) do not testify for any specific allegiance of chemists to positivism. Rather it suggests that the dilemma positivism vs realism is inappropriate for characterizing the ontology of chemistry. This alternative shaped at the turn of the twentieth century in the context of controversies about atomic physics does not take into account the major concern of chemists, i.e. making up things. Only by considering what matters for chemists, their matters of concern rather than their matter theories, can we expect to get an insight on their ontological assumptions. The argumentation based on historical data is twofold. It is wellknown that generating new substances out of initial ingredients which is the raison d'être of chemistry raised a vexing puzzle which has been alternatively solved with the Aristotelian notion of mixt and the Lavoisieran notion of compound. I argue that an essential tension remains intrinsic in chemistry between the two conceptual frameworks. The second section tries to make sense of the long tradition in chemistry of ontological noncommitment. I argue that what is usually considered as a denial of the existence of the basic units of matter would be better characterized as a focus on more important actors on the chemical stage. (shrink)

This paper examines the efforts of two young Russian chemists during the late 1850s and early 1860s to establish a professional chemistry journal and a public laboratory for chemistry research in Russia. These two, N. N. Sokolov and A. N. Engel' gardt, were important participants in the early efforts to institutionalize and professionalize chemistry in Russia. However, both the chemistry laboratory and the chemistry journal ended after only a few years. The chemistry journal was (...) curtailed not because of Government interference, as is sometimes asserted, but because of a conflict over editorial policy and independence. The chemistry laboratory was closed and the equipment donated to St Petersburg University when Sokolov was appointed to the position of adjunct there. (shrink)

Differing views on reduction are briefly reviewed and a suggestion is made for a working definition of 'approximate reduction'. Ab initio studies in quantum chemistry are then considered, including the issues of convergence and error bounds. This includes an examination of the classic studies on CH2 and the recent work on the Si2C molecule. I conclude that chemistry has not even been approximately reduced.

Kant’s treatment of organic phenomena in the third _Critique_ is relatively well-known. Less known is that Schelling offered an original answer to the same problems in his early writings on the philosophy of nature. Even less known is the significance of his rethinking of the role of chemistry in his approach to organic phenomena. In this article, after outlining the problem of organic phenomena at the end of the eighteenth century, I reconstruct Schelling’s account of chemistry against the (...) background of Kant’s theory of matter. I show that, while Schelling endorses Kant’s verdict that chemistry is not a proper science, he nevertheless assigns to it a far greater scope and explanatory power than Kant does. After that, I briefly sketch Schelling’s solution to the problem of organic phenomena while stressing the significance of his thinking about chemistry for this solution. (shrink)

Along with exploring some of the necessary conditions for the chemistry of our world given what we know about quantum mechanics, I will also discuss a different reductionist challenge than is usually considered in debates on the relationship of chemistry to physics. Contrary to popular belief, classical physics does not have a reductive relationship to quantum mechanics and some of the reasons why reduction fails between classical and quantum physics are the same as for why reduction fails between (...) chemistry and quantum physics. However, a neoreductionist can accept that classical physics has some amount of autonomy from quantum mechanics, but still try to maintain that classical+quantum physics taken as a whole reduces chemistry to physics. I will explore some of the obstacles lying in the neoreductionist’s path with respect to quantum chemistry and thereby hope to shed more light on the conditions necessary for the chemistry of our world. (shrink)

This chapter contains sections titled: Introduction What is Chemistry about? Is Chemistry Reducible to Physics? Are There Fundamental Limits to Chemical Knowledge? Is Chemical Research Ethically Neutral? Conclusion References.

The birth of a new discipline, called 'physical chemistry', is sometimes related to the names OSTWALD, ARRHENIUS and VAN'T HOFF and dated back to the year 1887, when OSTWALD founded the Zeitschrift für physikalische Chemie.[1] But as many historians have pointed out, the phrase 'physical chemistry' was widely used before that and the topics under investigation partially go back to Robert BOYLE's attempts to connect chemistry with concepts of mechanical philosophy.[2] The idea of a sudden birth of (...) physical chemistry in 1887 seems to be a founder myth.[3] But there is no doubt that in the late nineteenth-century there was a rapid growth of research in fields now understood as physical chemistry: chemical thermodynamics, electrochemistry, photochemistry, spectroscopy, chemical kinetics etc. (shrink)

This is an attempt to take a look at chemistry from the point of view of practical realism. Besides its social–historical and normative aspects, the latter involves a direct reference to experimental research. According to Edward Caldin chemistry depends on our being able to isolate pure substances with reproducible properties. Thus, the very basis of chemistry is practical. Even the laws of chemistry are not stable but are subject to correction. At the same time, these statements (...) do not necessarily make Edward Caldin a predecessor of practical realism. The latter has other predecessors, like Rom Harré’s policy realism or Sami Pihlström’s pragmatic realism. Chemistry is an experimental science. The experiment is a purposeful and critically theory-guided constructive, manipulative, material interference with nature according to Rein Vihalemm, the founder of practical realism. Chemistry is physics-like science but just partly so. This is an important point in the context of the current paper. (shrink)

By a close examination of changes in analytical chemistry between the years 1920 and 1950, I document the case that natural science has undergone and continues to undergo a major revolution. The central feature of this transformation is the rise in importance of scientific instrumentation. Prior to 1920, analytical chemists determined the chemical constitution of some unknown by treating it with a series of known compounds and observing the kind of reactions it underwent. After 1950, analytical chemists determined the (...) chemical constitution of an unknown by using a variety of instruments which allow one to discriminate chemicals in terms of their physical properties. This transformation involved changes in the practice of analytical chemistry. It involved the development of a new family of scientific instrument-making companies, and a new level of capital expenditure necessary to do analytical chemistry. It involved the development of new means to disseminate information about scientific instruments. While I do not document the broader case, these changes have been widespread throughout the natural sciences. It is the rise in the importance of instrumentation which is the key conceptual change in what has been identified as the fourth big scientific revolution. (shrink)

Summary Opinion is divided as to whether chemistry is reducible to physics. The problem can be given a satisfactory solution provided three conditions are met: that a science not be identified with its theories; that several notions of theory dependence be distinguished; and that quantum chemistry, rather than classical chemistry, be compared with physics. This paper proposes to perform all three tasks. It does so by analyzing the methodological concepts concerned as well as by examining the way (...) a chemical rate constant is derivable with the help of the quantum atomic theory. The conclusion is that chemistry, and in particular quantum chemistry, is not a part of physics although it is certainly based on the latter. (shrink)

During the second half of the twentieth century, the domain of geochemistry has greatly expanded and the field is today often seen as a branch of an extended chemistry of the Earth, called cosmochemistry. This paper is a historical introduction to cosmochemistry in which the wider cosmic aspects are surveyed up to about 1915, when nuclear physics changed the scene. These wider aspects or themes include, firstly, the attempts to determine the relative abundances of the elements, secondly, the extension (...) of geochemistry to include physical geochemistry, thirdly, the study of meteorites and, fourthly, the spectroscopic study of the stars within the astrochemical tradition. Because of the lack of reliable data, a great deal of the protocosmochemistry described in the present paper was speculative. Nonetheless, by 1915 the contours of the cosmochemistry of the future were just visible and the developments here singled out can thus be seen as belonging to the prehistory of modern cosmochemistry. (shrink)

This article focuses on the history of the customs laboratories in the United States between the 1870s and the 1930s, focusing especially on the decades up to World War I. It pays attention to the various dimensions of these laboratories, in particular the context of their creation. The first customs laboratory was established in New York in 1878, and over the subsequent years, similar laboratories were set up across the country. The evolution of this network was influenced by factors such (...) as the increasing specialization of these spaces, their geographic distribution, and changes in their organization and scope. The article also explores the types of imported merchandise analyzed in these labs; the roles of their staff, especially customs chemists, both within and outside these laboratories; their impact on the circulation of goods and in generating revenue from taxation; and the main challenges faced by customs chemists in adapting and standardizing their work. After discussing the necessity of customs laboratories in the United States, the article examines their progressive specialization, with a detailed study of the customs laboratory in New York. This laboratory was the largest and most significant due to its location and longevity. Finally, the paper considers the relationship between customs labs and the law, and how these spaces adapted to new challenges during the first third of the twentieth century. (shrink)

The focus of this contribution lies on eighteenth-century chemistry up to Lavoisier’s anti-phlogistic chemical system. Some main features of chemistry in this period will be examined by discussing classificatory practices and the understanding of the substances these practices imply. In particular, the question will be discussed of whether these practices can be regarded as natural historical practices and, hence, whether chemistry itself was a special natural history (part I). Furthermore, discussion of the famous Methode de nomenclature chimique (...) (1787) raises the question of what modes of classification tell us about chemists’ understanding of the substances they deal with (part II). Finally, in investigating what taxonomic orders reveal about deep structures of chemists’ understanding of the world of substances, the contribution will examine the question of whether Lavoisier’s anti-phlogistic chemical system was a revolution on the level of a deep structure or a revision within the untouched frame of such a structure (part III). (shrink)

In his Metaphysische Anfangsgründe der Naturwissenschaft (MAN), Kant claims that chemistry is an improper, though rational science. The chemistry to which Kant confers this status is the phlogistic chemistry of, for instance, Georg Stahl. In his Opus Postumum (OP), however, Kant espouses a broadly Lavoiserian conception of chemistry. In particular, Kant endorses Antoine Lavoisier's elements, oxygen theory of combustion, and role for the caloric. As Lavoisier's lasting contribution to chemistry, according to some histories of the (...) science, was his emphasis on quantitative methods, Kant's assimilation of the chemical revolution raises the question: did Kant continue to think of chemistry as an improper, though rational, science in OP? In this paper, I answer this question affirmatively. I explain that a proper science requires a priori laws for the mathematical construction of its objects: the mere use of quantitative measurements is insufficient for the satisfaction this requirement. Further, I argue, contra Burkhard Tuschling, that in OP Kant retains a central role for mathematical construction in the foundations of proper natural science. Finally, I contend that the prominent a priori components of chemistry discussed in OP—the aether and the enumeration of the elements—do not make chemistry into a proper science. (shrink)

Are there circumstances under which scientists and engineers doing their ordinary jobs can be thought of as participants in a social movement? The technoscientists analyzed in this article are at the forefront of a new way of doing chemistry; they are attempting to redesign chemical products and synthesis pathways to significantly reduce health effects and environmental damage from industrial chemicals. Green chemistry practitioners and entrepreneurs now constitute a small minority of chemists and chemical engineers in the university, government, (...) and corporate sectors, but the innovators gradually are institutionalizing their efforts and winning converts. Drawing on concepts from social movement theory, the authors argue that examining green chemistry as a social movement sheds light on the intentional social organization of emerging scientific and engineering disciplines, advances thinking about the role of expertise in social change, and uncovers a possible pathway toward reconstructing chemical technologies on a more environmentally sustainable basis. The article closes with questions about potential coalitions among green chemists and engineers, regulators, and activist sectors of civil society. (shrink)

Plato's geometrical theory of what we now call chemistry, set out in the Timaeus, uses triangles, his stoicheia, as the fundamental units with which he constructs his four elements. A paper claiming that these triangles can be divided indefinitely is criticized; the claim of an error here in the commentary by F.M. Cornford is unfounded. Plato's constructions of the elements are analyzed using simple point group theory. His procedure generates fully symmetric polyhedra, but Cornford's 'simpler' alternatives generate polyhedra with (...) low symmetries and multiple isomeric forms. However, Cornford's principle of constructing larger triangles by assembling smaller ones is still valid. (shrink)

Lately there has been a growing interest in evolutionary studies concerning how the regularities and patterns found in the living cell could have emerged spontaneously by way of self-assembly and self-organization. It is reasonable to postulate that the chemical compounds found in the primitive Earth would have mostly been very simple in nature, and would have been immersed in the natural dynamics of the physical world, some of which would have involved self-organization. It seems likely that some molecular processes self-organized (...) spontaneously into a hierarchy of complex behaviours. Our conceptual search herein reaches back to the time when prebiotic phenomena began to take shape. This was before the origin of life, so in this paper we hope to shed new light on some of the theoretical issues that surround the ways in which cellular organization might have evolved without the aid of replicated information. (shrink)

During the second half of the nineteenth century, electronegativity has been one of the most relevant chemical concepts to explain the relationships between chemical substances and their possible reactions. Specifically, EN is a property of the substances that allows them to attract external electrons in bonding situations. The problem arises because EN cannot be measured directly. Indeed, the only way to measure it is through different properties that do can be directly measured, for instance enthalpy, ionization energies or electron affinities. (...) What is particularly troubling about this case in quantum chemistry is that the different models used to describe and quantify EN are incompatible but, in a certain sense, equivalent because the same EN scale results in all of them. By analyzing Linus Pauling’s and Robert Mulliken’s models of EN, it will be argued that, if we remain cling to a traditional representative conception of models, we cannot understand the meaning of the information provided by those models. Indeed, if we do not want to adopt an instrumentalist point of view concerning chemical knowledge, we should reconsider by virtue of what a model represents the system, or, in other words, which the factors that determine the representative power of a model are. I will propose a new perspective that incorporates the role of experimental techniques in the very notion of representation; this perspective allows us to understand how supposedly incompatible models of the same target system can be both simultaneously representative. (shrink)

Chemistry, especially its historical practice, has in the philosophy of science in recent decades attracted more and more attention, influencing the turn from the vision of science as a timeless logic-centred system of statements towards the history- and practice-centred approach. The problem of pluralism in science has become a popular topic in that context. Hasok Chang’s “active normative epistemic pluralism” manifested in his book Is water H2O? Evidence, realism and pluralism, pursuing an integrated study of history and philosophy of (...) science, has provoked quite a widespread debate. It provides a good opportunity to discuss the topical philosophical issue of the nature of disagreements. The differences among disagreements in different domains have been pointed out in the disagreement literature. It has been noticed that in mathematics and science consensus is established more clearly than in philosophy where it remains largely unachievable. However, this conclusion is derived in the context of traditional logic-centred view of science. The aim of this paper is to consider the different nature of disagreements in science and in philosophy in the context of the history- and practice-centred approach. The analysis is focused on the critique of the received view of the Chemical Revolution which played quite a central role in Chang’s becoming a pluralist about science. Unlike Chang, however, a modified Kuhnian paradigm-conception of science and scientific revolutions is defended. (shrink)

The philosophical analysis of chemistry has advanced at such a pace during the last dozen years that the existence of philosophy of chemistry as an autonomous discipline cannot be doubted any more. The present paper will attempt to analyse the experience of philosophy of chemistry at the, so to say, meta-level. Philosophers of chemistry have especially stressed that all sciences need not be similar to physics. They have tried to argue for chemistry as its own (...) type of science and for a pluralistic understanding of science in general. However, when stressing the specific character of chemistry, philosophers do not always analyse the question ‘What is science?’ theoretically. It is obvious that a ‘monistic’ understanding of science should not be based simply on physics as the epitome of science, regarding it as a historical accident that physics has obtained this status. The author’s point is that the philosophical and methodological image of science should not be chosen arbitrarily; instead, it should be theoretically elaborated as an idealization (theoretical model) substantiated on the historical practice of science. It is argued that although physics has, in a sense, justifiably obtained the status of a paradigm of science, chemistry, which is not simply a physical science, but a discipline with a dual character, is also relevant for elaborating a theoretical model of science. The theoretical model of science is a good tool for examining various issues in philosophy of chemistry as well as in philosophy of science or science studies generally. (shrink)

Sanfte Chemie was a concept formulated in the 1980s in Germany by a group of environmentally conscious scholars. It emerged within a unique environment, marked by its radical critique of dominant forms of rationality, and against the rich background of German philosophical technocritical traditions. Its purpose was to profoundly reshape the practice of chemistry and the organization of the chemical industry along the lines of sustainability. In contrast to later concepts like green or sustainable chemistry, Sanfte Chemie went (...) beyond setting new research directions; it critically reevaluated the entire epistemological foundation upon which the science of chemistry was built. Under the auspices of the German Green Party, the concept flourished in the 1980s before falling out of grace in the following decade. While largely deemed overly radical in its time and then subsequently forgotten, Sanfte Chemie not only anticipated some of the most promising trends in sustainability science today but also offered unique insights that may shed new light on the challenges of the ongoing environmental crisis. (shrink)

The general knowledge and understanding that every teacher of religion and science should have relative to chemistry can be found in the answers to three major questions. In my own response to the first question, How did chemistry emerge as a discipline? I trace the origins, establishment, and subsequent historical significance of cosmology. I contend that chemistry is “the obvious, oldest science” and, as such, has played a key role among the sciences in agelong human efforts to (...) understand reality. In my response to the second question, How do chemists currently view (cosmic) reality? I outline three prominent examples in support of my contention that chemistry, despite being “the obvious, oldest science,” is seen by some as playing only a tacit role in current efforts to (re)integrate religion and science. In my response to the third question, How do chemists currently view ultimate reality and meaning? I argue that “unifiers” in chemistry can also now play a key role in a reality revolution that is pointing humankind not only toward a possible historical (re) integration of religion and science but also toward a return to cosmology. (shrink)

In 1931 eminent chemist Fritz Paneth maintained that the modern notion of “element” is closely related to (and as “metaphysical” as) the concept of element used by the ancients (e.g., Aristotle). On that basis, the element chlorine (properly so-called) is not the elementary substance dichlorine, but rather chlorine as it is in carbon tetrachloride. The fact that pure chemicals are called “substances” in English (and closely related words are so used in other European languages) derives from philosophical compromises made by (...) grammarians in the late Roman Empire (particularly Priscian [fl. ~520 CE]). When the main features of the constitution of isotopes became clear in the first half of the twentieth century, the formal (IUPAC) definition of a “chemical element” was changed. The features that are “essential” to being an element had previously been “transcendental” (“beyond the sphere of consciousness”) but, by the mid-twentieth century the defining characteristics of elements, as such, had come to be understood in detail. This amounts to a shift in a “horizon of invisibility” brought about by progress in chemistry and related sciences. Similarly, chemical insight is relevant to currently-open philosophical problems, such as the status of “the bundle theory” of the coherence of properties in concrete individuals. (shrink)

At first glance twentieth-century philosophy of science seems virtually to ignore chemistry. However this paper argues that a focus on chemistry helped shape the French philosophical reflections about the aims and foundations of scientific methods. Despite patent philosophical disagreements between Duhem, Meyerson, Metzger and Bachelard it is possible to identify the continuity of a tradition that is rooted in their common interest for chemistry. Two distinctive features of the French tradition originated in the attention to what was (...) going on in chemistry.French philosophers of science, in stark contrast with analytic philosophers, considered history of science as the necessary basis for understanding how the human intellect or the scientific spirit tries to grasp the world. This constant reference to historical data was prompted by a fierce controversy about the chemical revolution, which brought the issue of the nature of scientific changes centre stage.A second striking—albeit largely unnoticed—feature of the French tradition is that matter theories are a favourite subject with which to characterize the ways of science. Duhem, Meyerson, Metzger and Bachelard developed most of their views about the methods and aims of science through a discussion of matter theories. Just as the concern with history was prompted by a controversy between chemists, the focus on matter was triggered by a scientific controversy about atomism in the late nineteenth-century.Keywords: France; Epistemology; Chemistry; Revolution; Atomism; Realism. (shrink)

This is an attempt to take a look at chemistry from the point of view of practical realism. Besides its social–historical and normative aspects, the latter involves a direct reference to experimental research. According to Edward Caldin chemistry depends on our being able to isolate pure substances with reproducible properties. Thus, the very basis of chemistry is practical. Even the laws of chemistry are not stable but are subject to correction. At the same time, these statements (...) do not necessarily make Edward Caldin a predecessor of practical realism. The latter has other predecessors, like Rom Harré’s policy realism or Sami Pihlström’s pragmatic realism. Chemistry is an experimental science. The experiment is a purposeful and critically theory-guided constructive, manipulative, material interference with nature according to Rein Vihalemm, the founder of practical realism. Chemistry is physics-like science but just partly so. This is an important point in the context of the current paper. (shrink)

We analyze the connections of Lavoisier system of nomenclature with Leibniz’s philosophy, pointing out to the resemblance between what we call Leibnizian and Lavoisian programs. We argue that Lavoisier’s contribution to chemistry is something more subtle, in so doing we show that the system of nomenclature leads to an algebraic system of chemical sets. We show how Döbereiner and Mendeleev were able to develop this algebraic system and to find new interesting properties for it. We pointed out the resemblances (...) between Leibniz program and Lavoisier legacy, particularly regarding the lingua philosophica for understanding and thinking Nature, in this particular case, chemistry. In the second part we discuss, from the linguistic viewpoint, how Lavoisian algebraic system may be taken further to build a language. We study the constituents of such a chemical language. Finally, we formalize some of the ideas here presented by using elements of network theory and discrete mathematics. (shrink)

In his Metaphysische Anfangsgründe der Naturwissenschaft, Kant claims that chemistry is a science, but not a proper science (like physics), because it does not adequately allow for the application of mathematics to its objects. This paper argues that the application of mathematics to a proper science is best thought of as depending upon a coordination between mathematically constructible concepts and those of the science. In physics, the proper science that exhausts the a priori knowledge of objects of the outer (...) sense, only motions and concepts reducible to motions can be legitimately coordinated with mathematical constructions. Since chemistry can neither achieve its own a priori principles of coordination nor be reduced to the coordinated doctrine of motion, it is a merely improper science. (shrink)