In this paper we contrast the simple role of FOXO in the seemingly non‐aging Hydra with its more diversified function in multicellular eukaryotes that manifest aging and limited life spans. From this comparison we develop the concept that, whilst once devoted to life‐prolonging cell‐renewal (in Hydra), evolutionary accumulation of coupled functionality in FOXO has since ‘distracted’ it from this role. Seen in this light, aging may not be the direct cost of competing functions, such as reproduction or growth, but the (...) result of a shift in emphasis in a protein, which is accompanied by advantages such as greater organismal complexity and adaptability, but also disadvantages such as reduced regeneration capacity. Studying the role of FOXO in non‐aging organisms might, therefore, illuminate the path to extend life span in aging organisms.Editor's suggested further reading in BioEssays Stem cells and aging from a quasi‐immortal point of view Abstract. (shrink)

Ever since Plato’s famous attack on artists and poets in Book 10 of The Republic, lovers of literature have felt pressed to defend poetry, and indeed from ancient times down to the present, literature and art have had to fight various battles against philosophy, religion, and science. After providing a brief overview of this conflict and then arguing that between poetry and science there are some noteworthy similarities---that is, that some of the basic mental structures with which the scientist studies (...) the “text‘ of nature (facts, laws, theories) find their counterparts in ways an informed reader studies the poetic text, I develop what I see as the most important differences between poetry, on the one hand, and science, philosophy, and theology, on the other. These differences lie chiefly in two areas: (1) in the stance that each takes toward language itself and (2) in the stance each takes toward that ancient polarity between the one and the many. The aim of my argument is neither to privilege poetry over the other modes of knowing the world nor to grant, particularly to science in its reductive “objectivity,‘ a higher epistemological status than that accorded to poetry and the arts. Instead, I wish to argue that science, by pushing the boundaries of knowledge about the material world, shows the poet, as well as the theologian, some of the more important work to be done and that poetry, with its emphasis on the particular over the abstract and on the ambiguities and paradoxes of language as inherently metaphorical, serves science and religion by providing a caution against the naive acceptance of language as literal and the consequent enthrallment to the power of absolutes and totalizing abstractions. (shrink)

By tracing the trajectory of his own personal and professional life, the author provides a perspective on how intellectual and religious or spiritual growth, while often seemingly at odds with each other, can nonetheless advance in a mutually enhancing manner. The historical conflict between literature and science is briefly outlined as a parallel to that between religion and science, and the importance of metaphor as a common element in all three fields is explored. Emphasis is placed on metaphor as a (...) means of challenging absolutism, encouraging humility, and promoting a sense of wonder about the universe. (shrink)

Most recent writing linking science and literature has concerned itself with challenges to the epistemological status of scientific knowledge in an attempt to demonstrate its contingency, arguing in the more radical efforts that the structures of science are no more than useful fictions. This essay also includes an epistemological comparison between science and literature, but instead of making grand or meta–statements about the nature of knowing generally in the two fields, mine is a much narrower aim. My exploration entails two (...) tasks. First, I provide a close–up look at a particular type of experiment, called the delayed–choice experiment, which clearly reveals the strangeness of the quantum world. In connection with this experiment, I discuss wave functions—mathematical expressions used by physicists to describe quantum behavior and predict the outcome of experiments involving quanta. Second, I look at Walt Whitman's “Song of Myself” focusing on the meaning of the “self” in the poem. My aim is to treat the object of study in each field as a “text” and to assert and demonstrate a parallel in the strategies of thought and response between physicists (“readers”) pondering the meaning and status of a wave function and poem readers pondering the meaning and status of the poem's self. In Whitman's “Song” we find an attempt to understand complex aspects of human experience that are said to transcend ordinary reality, an effort for which I believe there are parallels in the attempts of modern physicists to understand complex, nonintuitive aspects of the subatomic world. While not making the kind of broad claims eschewed above, I do suggest that this focused study has interesting implications since both the wave function and the poem's self force their respective sets of “readers” to confront questions of ultimacy—to consider, that is, epistemological and ontological issues of more than passing interest to students of science as well as those of metaphysics and theology. (shrink)

This paper distinguishes bruteness from fundamentality by developing a theory of stochastic grounding that makes room for non-fundamental bruteness. Stochastic grounding relations, which only underwrite incomplete explanations, arise when the fundamental level underdetermines derivative levels. The framework is applied to fission cases, showing how one can break symmetries and mitigate bruteness whilst avoiding arbitrariness and hypersensitivity.

First published in 1992. Routledge is an imprint of Taylor & Francis, an informa company.

ABSTRACTThis paper addresses the problem of opaque sweetening and argues that one should use stochastic dominance in comparing lotteries even when dealing with incomplete orderings that allow for non-comparable outcomes.

This paper assesses the role of the Refutation of Idealism within the Critique of Pure Reason, as well as its relation to the treatment of idealism in the First Edition and to transcendental idealism more generally. It is argued that the Refutation is consistent with the Fourth Paralogism and that it can be considered as an extension of the Transcendental Deduction. While the Deduction, considered on its own, constitutes a 'regressive argument', the Refutation allows us to turn the Transcendental Analytic (...) into a 'progressive argument' that proceeds by the synthetic method. (shrink)

Currently, two frameworks of causal reasoning compete: Whereas dependency theories focus on dependencies between causes and effects, dispositional theories model causation as an interaction between agents and patients endowed with intrinsic dispositions. One important finding providing a bridge between these two frameworks is that failures of causes to generate their effects tend to be differentially attributed to agents and patients regardless of their location on either the cause or the effect side. To model different types of error attribution, we augmented (...) a causal Bayes net model with separate error sources for causes and effects. In several experiments, we tested this new model using the size of Markov violations as the empirical indicator of differential assumptions about the sources of error. As predicted by the model, the size of Markov violations was influenced by the location of the agents and was moderated by the causal structure and the type of causal variables. (shrink)

In this paper, the results of an empirical analysis of a set of 416 descriptive case studies published by corporate members of the UN Global Compact are presented. Although these cases cannot be viewed as representative of the Compact itself or of corporate social responsibility (CSR) and development in general, they can illustrate which kinds of projects are deemed appropriate as best practice examples among Compact members, and therefore indicate the direction, in which predominantly voluntary and business‐led CSR might at (...) best be evolving. To help contextualize the analysis, the paper starts with a brief overview of recent academic work on the strengths and limitations of CSR in the light of international development, followed by the empirical analysis of Compact case studies. The results raise doubts regarding the general suitability of contemporary CSR initiatives to tackle some of the most pressing developmental challenges. Instead, only certain topics are commonly addressed, while a number of issues such as anti‐corruption measures or labour rights are underrepresented in the case study sample. Regarding the target regions of the best practice examples, the majority is reported on activities based in OECD countries and a small number of emerging markets such as South Africa, India or China, while neglecting other regions such as sub‐Saharan Africa (excluding South Africa). From a European Union policy perspective, these results indicate that there is a role to play for the state in order to create a better fit between CSR agendas and the actual developmental needs in the South. (shrink)

This chapter provides an account of the Kantian theory of value, showing how a plurality of incommensurable values, namely the fundamentally heterogeneous values of morality and prudence, can be integrated into a complete ordering by appealing to the conditionality of the value of happiness, which allows us to explain how the claims of prudence can be silenced by the claims of morality, thereby solving the Sidgwickian problem of the dualism of practical reason. Moreover, it establishes that the Kantian understanding of (...) silencing is the only way of rendering dualism coherent, given that the question as to what one ought to do, considering all the normative demands to which one is subject, requires either that these demands be commensurable, which presupposes monism, or that these demands never conflict, which can only be ensured in principle by means of conditional value structures. (shrink)

This paper establishes that the occasional identity relation and the contingent identity relation are both non-transitive and as such are not properly classified as identity relations. This is achieved by appealing to cases where multiple fissions and fusions occur simultaneously. These cases show that the contingent and occasional identity relations do not even satisfy the time-indexed and world-indexed versions of the transitivity requirement and hence are non-transitive relations.

In der 1970 gegründeten Reihe erscheinen Arbeiten, die philosophiehistorische Studien mit einem systematischen Ansatz oder systematische Studien mit philosophiehistorischen Rekonstruktionen verbinden. Neben deutschsprachigen werden auch englischsprachige Monographien veröffentlicht. Gründungsherausgeber sind: Erhard Scheibe (Herausgeber bis 1991), Günther Patzig (bis 1999) und Wolfgang Wieland (bis 2003). Von 1990 bis 2007 wurde die Reihe von Jürgen Mittelstraß mitherausgegeben.

ABSTRACTOne prestudy based on a corpus analysis and four experiments in which participants had to invent novel names for persons or objects investigated how the valence of a face or an object affects the phonological characteristics of the respective novel name. Based on the articulatory feedback hypothesis, we predicted that /i:/ is included more frequently in fictional names for faces or objects with a positive valence than for those with a negative valence. For /o:/, the pattern should reverse. An analysis (...) of the Berlin Affective Word List – Reloaded yielded a higher number of occurrences of /o:/ in German words with negative valence than in words with positive valence; with /i:/ the situation is less clear. In Experiments 1 and 2, participants named persons showing a positive or a negative facial expression. Names for smiling persons included more /i:/s and fewer /o:/s than names for persons with a negative facial expression. In Experiments 3 and 4, participant... (shrink)

Objectives Medical futility at the end of life is a growing challenge to medicine. The goals of the authors were to elucidate how clinicians define futility, when they perceive life-sustaining treatment (LST) to be futile, how they communicate this situation and why LST is sometimes continued despite being recognised as futile. Methods The authors reviewed ethics case consultation protocols and conducted semi-structured interviews with 18 physicians and 11 nurses from adult intensive and palliative care units at a tertiary hospital in (...) Germany. The transcripts were subjected to qualitative content analysis. Results Futility was identified in the majority of case consultations. Interviewees associated futility with the failure to achieve goals of care that offer a benefit to the patient's quality of life and are proportionate to the risks, harms and costs. Prototypic examples mentioned are situations of irreversible dependence on LST, advanced metastatic malignancies and extensive brain injury. Participants agreed that futility should be assessed by physicians after consultation with the care team. Intensivists favoured an indirect and stepwise disclosure of the prognosis. Palliative care clinicians focused on a candid and empathetic information strategy. The reasons for continuing futile LST are primarily emotional, such as guilt, grief, fear of legal consequences and concerns about the family's reaction. Other obstacles are organisational routines, insufficient legal and palliative knowledge and treatment requests by patients or families. Conclusion Managing futility could be improved by communication training, knowledge transfer, organisational improvements and emotional and ethical support systems. The authors propose an algorithm for end-of-life decision making focusing on goals of treatment. (shrink)

This book collects twelve original articles, arranged in three sections, plus an introduction.

The present paper investigates the power of proper forcings to change the shape of the universe, in a certain well-defined respect. It turns out that the ranking among large cardinals can be used as a measure for that power. However, in order to establish the final result I had to isolate a new large cardinal concept, which I dubbed “remarkability.” Let us approach the exact formulation of the problem—and of its solution—at a slow pace.Breathtaking developments in the mid 1980s found (...) one of its culminations in the theorem, due to Martin, Steel, and Woodin, that the existence of infinitely many Woodin cardinals with a measurable cardinal above them all implies that AD, the axiom of determinacy, holds in the least inner model containing all the reals, L. One of the nice things about AD is that the theory ZF + AD + V = L appears as a choiceless “completion” of ZF in that any interesting question seems to find an at least attractive answer in that theory. Beyond that, AD is very canonical as may be illustrated as follows.Let us say that L is absolute for set-sized forcings if for all posets P ∈ V, for all formulae ϕ, and for all ∈ ℝ do we have thatwhere is a name for the set of reals in the extension. (shrink)

This paper develops co-ordinated multiple-domain supervenience relations to model determination and dependence relations between complex entities and their constituents by appealing to R-related pairs and by making use of associated isomorphisms. Supervenience relations are devised for order-sensitive and repetition-sensitive mereologies, for mereological systems that make room for many-many composition relations, as well as for hierarchical mereologies that incorporate compositional and hylomorphic structure. Finally, mappings are provided for theories that consider wholes to be prior to their parts.

Let L[E] be an iterable tame extender model. We analyze to which extent L[E] knows fragments of its own iteration strategy. Specifically, we prove that inside L[E], for every cardinal K which is not a limit of Woodin cardinals there is some cutpoint t K > a>ω1 are cardinals, then ◊$_{K.\lambda }^* $ holds true, and if in addition λ is regular, then ◊$_{K.\lambda }^* $ holds true.

Inductive Metaphysics combines an anti-aprioristic emphasis on an empirical and scientific basis for metaphysics with an insistence on a specifically philosophical abductive theory-building. Since the latter specifically philosophical work is not empirical itself, it may in a liberal sense be called apriori. This paper highlights this apriori dimension within IM by a case study on Structuralism, the view that fundamental reality consists of a network of relations, which a number of philosophers consider to be suggested by modern physics. Focussing on (...) Dasgupta’s algebraic Generalism, the author argues that Structuralism suffers from a severe entailment problem, because the relations-spanning apparatus must stand for metaphysically fundamental forms. Schaffer’s contention that there are no entailment problems is rejected. Advocates of IM are well advised to take seriously their own insistence on metaphysical abduction and not to one-sidedly emphasise the empirical input: the elaboration of exact metaphysical theories and the apriori evaluation of their inherent tenability is a constituent of IM no less important than the consideration of scientific input. More traditional ways of metaphysical reasoning inevitably survive as an essential dimension within IM. (shrink)

Let N be a transitive model of ZFC such that ωN ⊂ N and P(R) ⊂ N. Assume that both V and N satisfy "the core model K exists." Then KN is an iterate of K. i.e., there exists an iteration tree J on K such that J has successor length and $\mathit{M}_{\infty}^{\mathit{J}}=K^{N}$. Moreover, if there exists an elementary embedding π: V → N then the iteration map associated to the main branch of J equals π ↾ K. (This answers (...) a question of W. H. Woodin, M. Gitik, and others.) The hypothesis that P(R) ⊂ N is not needed if there does not exist a transitive model of ZFC with infinitely many Woodin cardinals. (shrink)

Der vorliegende Beitrag soll das Verständnis von Freuds Traumtheorie erleichtern. Die vorgestellte neue Perspektive basiert auf dem fünften Kapitel von Freuds »Abriß der Psychoanalyse« (1940a). Dieses Kapitel enthält eine kompakte Zusammenfassung von Freuds Traumtheorie unter Anwendung des strukturellen Gesichtspunktes. Die Autoren schlagen vor, dieses Kapitel als eine Art Lesehilfe für die Lektüre der »Traumdeutung« zu verwenden, was durch einige Absätze aus deren siebtem Kapitel illustriert wird. Auf diese Weise soll deutlich gemacht werden, dass »Die Traumdeutung« nicht umgeschrieben werden muss, um (...) den strukturellen Gesichtspunkt zu integrieren. Vielmehr können der topographische und der strukturelle Gesichtspunkt elegant zusammengeführt werden. Anschließend wird die überdachte Lesart mit einigen früheren Publikationen aus der psychoanalytischen Literatur verglichen, und es werden Implikationen für die klinische Anwendung der Traumtheorie diskutiert. Abschließend wird die neue Lesart von Freuds Traumtheorie in zehn Punkten zusammengefasst. (shrink)

We introduce 0• as a sharp for an inner model with a proper class of strong cardinals. We prove the existence of the core model K in the theory “ does not exist”. Combined with work of Woodin, Steel, and earlier work of the author, this provides the last step for determining the exact consistency strength of the assumption in the statement of the 12th Delfino problem pp. 221–224)).

Strong dispositional monism, the position that all fundamental physical properties consist in dispositional relations to other properties, is naturally construed as property structuralism. J. Lowe’s circularity/regress objection constitutes a serious challenge to SDM that questions the possibility of a purely relational determination of all property essences. The supervenience thesis of A. Bird’s graph-theoretic asymmetry reply to CRO can be rigorously proved. Yet the reply fails metaphysically, because it reveals neither a metaphysical determination of identities on a purely relational basis nor (...) a determination specifically of identities in the sense of essences. Asymmetry is thus not by itself sufficient for a solution to CRO. But it cannot even help to answer CRO when a model for the determination of essences is taken as a basis. Nor is asymmetry necessary for a reply, as property structures may well be symmetric. A metaphysics of dispositional properties as grounded in a purely relational structure faces serious obstacles, and the properties would not be fundamental. Since essence and grounding are notions of metaphysical priority, there can be no essentially dispositional metaphysically fundamental properties, and the prospects of a “coherentist” metaphysics of basic properties are dim. A modal retreat that refrains from a post-modal conception of essence and simply claims that fundamental properties play dispositional roles by metaphysical necessity is unsatisfactory. (shrink)

This paper provides an account of Kant's categories of freedom, explaining how they fit together and what role they are supposed to play. My interpretation places particular emphasis on the structural features that the table of the categories of freedom shares with the table of judgements and the table of categories laid out by Kant in the Critique of Pure Reason. In this way we can identify two interpretative constraints, namely (i) that the categories falling under each heading must form (...) a synthetic unity whereby the third one derives from the combination of the other two. and (ii) that the first two categories falling under each heading must be morally undetermined and sensibly conditioned, while the third category is sensibly unconditioned and determined only by the moral law. (shrink)

We show that L absoluteness for semi-proper forcings is equiconsistent with the existence of a remarkable cardinal, and hence by [6] with L absoluteness for proper forcings. By [7], L absoluteness for stationary set preserving forcings gives an inner model with a strong cardinal. By [3], the Bounded Semi-Proper Forcing Axiom is equiconsistent with the Bounded Proper Forcing Axiom , which in turn is equiconsistent with a reflecting cardinal. We show that Bounded Martin's Maximum is much stronger than BSPFA in (...) that if BMM holds, then for every X ∈ V , X# exists. (shrink)