Name der Zeitschrift: Kant-Studien Jahrgang: 109 Heft: 1 Seiten: 147-169.

Obesity and type 2 diabetes arise from a set of complex gene–environment interactions. Explanations for the heritability of these syndromes and the environmental contribution to disease susceptibility are addressed by the “thrifty genotype” and the “thrifty phenotype” hypotheses. Here, the merits of both models are discussed and elements of them are used to synthesize a “thrifty epigenotype” hypothesis. I propose that: (1) metabolic thrift, the capacity for efficient acquisition, storage and use of energy, is an ancient, complex trait, (2) the (...) environmentally responsive gene network encoding this trait is subject to genetic canalization and thereby has become robust against mutational perturbations, (3) DNA sequence polymorphisms play a minor role in the aetiology of obesity and type 2 diabetes—instead, disease susceptibility is predominantly determined by epigenetic variations, (4) corresponding epigenotypes have the potential to be inherited across generations, and (5) Leptin is a candidate gene for the acquisition of a thrifty epigenotype. BioEssays 30:156–166, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

In Hobbes' Theorie des Leviathan sind weder der Naturzustand noch der staatliche Zustand und das Strafrecht widersprüchlich. Der radikale Subjektivismus ist der archimedische Punkt, von dem aus sich die scheinbaren Widersprüche auflösen lassen. Locke kehrt zu einem Rechtsobjektivismus zurück, hat aber kein Prinzip der Begrenzung von Strafen.

Crusius est consideré comme l'un des plus importants critiques des théories philosophiques de Leibniz et de Wolff. Dans ce contexte, outre la critique de l'interprétation du principe de la raison telle que l'ont soutenue Leibniz et Wolff, il faut surtout citer le refus de l'utilisation de la méthode mathématique dans la philosophie. Le développement de la théorie des substances simples conçue par Crusius servira d'exemple pour démontrer le refus de cette méthode dans la métaphysique. La définition de la substance simple, (...) à laquelle Crusius parvient en ce fondant sur la distinction entre raison d'être et raison de connaître, s'offre à la pensée de Leibniz comme à la pensée de Wolff. Cependant, quand Crusius rejette l'interprétation de la substance simple comme point mathématique, il attaque surtout Leibniz. Ainsi la théorie de Crusius des substances simples doit être avant tout considéré comme une critique de la monadologie leibnizienne. (shrink)

One of the two oldest manuscripts of Greek canon law, the Codex Patmiacus 172, sheds new light on the history of the Council in Trullo . Whereas from the other 45 extant manuscripts only 220 episcopal signatures to this Council have been known so far, the Patmiacus has preserved 6 additional signatures and thus raises the number of the hitherto known clerical participants to 226, representing a total of 227 bishoprics. Since these subscriptions are preceded by the signature of the (...) Emperor, the Patmiacus is the sole extant manuscript that bears in fact a total of 227 signatures, the number of participants assigned to this Council in the later canonistic tradition. Besides, this manuscript offers a great number of additions and corrections to the other 220 signatures. Due to the discovery of the six new episcopal signatures, however, the question of authenticity of the six position markers found in some manuscripts to indicate the place for the signatures of six episcopal sees which were present at the Sixth Ecumenical Council in 681/82 but apparently absent in 691/92 must be reconsidered. Whereas so far these markers have been considered original because it was only by their connumerating that the number of 227 could be achieved, this argument has become obsolete by the subscription list of the Patmiacus. Furthermore, the missing of the first three markers in the oldest extant manuscripts as well as their odd positions makes it very likely that they are not original but were interpolated at the times of the Seventh Ecumenical Council in order to assimilate the beginning of the subscription list of the Council of 691/92 to the one of 681/82 and thus substantiating Tarasios' claim that the Council in Trullo was a continuation of the Sixth Ecumenical Council. Whether the West and the metropolitan sees present in 681/82 - Rome, Thessaloniki, Sardinia, Ravenna and Corinth - were in fact invited as well to the Council in 691/92 is once again an open question and cannot be answered by reference to the manuscript tradition. Finally, the reasons for the western opposition to this Council are not so much to be sought in the form of the subscription list but more in the content of the canons and the Logos Prosphonetikos. (shrink)

Honeybees display a fascinating social behavior. The structural basis for this behavior, which made the bee a model organism for the study of communication, learning and memory formation, is the tiny insect brain. Neurons of the brain communicate via messenger molecules. Among these molecules, neuropeptides represent the structurally most‐diverse group and occupy a high hierarchic position in the modulation of behavior. A recent analysis of the honeybee genome revealed a considerable number of predicted (200) and confirmed (100) neuropeptides in this (...) insect.1 Is this quantity merely the result of advanced mass spectrometric techniques and bioinformatic tools or does it reflect the expression of more of these important messenger molecules, more than known from other insects studied so far? Our analysis of the data suggests that the social behavior is by no means correlated with a specific increase in the number of neuropeptides. Indeed, the honeybee genome is likely to contain fewer neuropeptide genes, neuropeptide paralogues and neuropeptide receptor genes than the solitary fruitfly Drosophila. BioEssays 29:416–421, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Uniformities describing the distinguishability of states and of observables are discussed in the context of general statistical theories and are shown to be related to distinguished subspaces of continuous observables and states, respectively. The usual formalism of quantum mechanics contains no such physical uniformity for states. Using recently developed tools of quantum harmonic analysis, a natural one-to-one correspondence between continuous subspaces of nonrelativistic quantum and classical mechanics is established, thus exhibiting a close interrelation between physical uniformities for quantum states and (...) compactifications of phase space. General properties of the completions of the quantum state space with respect to these uniformities are discussed. (shrink)

This is a concise guide to the educational philosophy of Rudolf Steiner. He pioneered a comprehensive, co-educational form of holistic education for children from kindergarten to the end of high school.