Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Claire Katz & Lara Trout, Emmanuel Levinas. Critical Assessments of Leading Philosophers ; Thomas Bedorf, Andreas Cremonini, Verfehlte Begegnung. Levinas und Sartre als philosophische Zeitgenossen ; Samuel Moyn, Origins of the Other: Emmanuel Levinas between Revelation and Ethics ; Pascal Delhom & Alfred Hirsch, Im Angesicht der Anderen. Levinas’ Philosophie des Politischen ; Sharon Todd, Learning from the other: Levinas, psychoanalysis and ethical possibilities in education ; Michel Henry, Le bonheur de Spinoza, suivi de: Etude sur le spinozisme de Michel (...) Henry, par Jean-Michel Longneaux ; Jean-François Lavigne, Husserl et la naissance de la phénoménologie. Des Recherches logiques aux Ideen: la genèse de l’idéalisme transcendantal phénoménologique ; Denis Seron, Objet et signification ; Dan Zahavi, Sara Heinämaa and Hans Ruin, Metaphysics, Facticity, Interpretation. Phenomenology in The Nordic Countries ; Dimitri Ginev, Entre anthropologie et herméneutique ; Magdalena Mărculescu-Cojocea, Critica metafizicii la Kant şi Heidegger. Problema subiectivităţii: raţiunea între autonomie şi deconstrucţie. (shrink)

In this contribution the author tries to show the relation between Lévinas and Husserl regarding the question of language and tongue. He begins by explaining what is the conception of language in the Logical Investigations and of tongue in Ideas II. The former allows Husserl to develop a univocal language, whereas the second reinscribes the tongue in the body with his intersubjective dimension. Husserl will have an influence on Lévinas, but the latter will reject his conception of language, for being (...) too formal, and hold Husserl’s concept of the tongue to be a presupposition. Thus, the tongue becomes the way the alterity of the other expresses itself, the way a meaning appears independently from the subject. (shrink)

The essential companion to Stieg Larsson's bestselling trilogyand director David Fincher's 2011 film adaptation Stieg Larsson's bestselling Millennium Trilogy—The Girlwith the Dragon Tattoo, The Girl Who Played with Fire, andThe Girl Who Kicked the Hornet's Nest—is aninternational phenomenon. These books express Larsson's lifelongwar against injustice, his ethical beliefs, and his deep concernfor women's rights. The Girl with the Dragon Tattoo andPhilosophy probes the compelling philosophical issues behindthe entire trilogy. What philosophies do Lisbeth Salander and Kanthave in common? (...) To catch a criminal, can Lisbeth and Mikael becriminals themselves? Can revenge be ethical? Drawing on some ofhistory's greatest philosophical minds, this book gives freshinsights into Larsson's ingeniously plotted tale of crime andcorruption. Looks at compelling philosophical issues such as a feministreading of Lisbeth Salander, Aristotelian arguments for why we loverevenge, how Kant can explain why so many women sleep with MikaelBlomkvist, and many more Includes a chapter from a colleague of Larsson's—whoworked with him in anti-Nazi activities—that exploresLarsson's philosophical views on skepticism and quotes fromnever-before-seen correspondence with Larsson Offers new insights into the novels' key characters, includingLisbeth Salander and Mikael Blomkvist, and investigates the author,Stieg Larsson As engrossing as the quest to free Lisbeth Salander from herpast, The Girl with the Dragon Tattoo and Philosophy isideal reading for anyone interested in unraveling the subtext andexploring the greater issues at work in the story. (shrink)

Im Zentrum der Untersuchung steht die Philosophie des modernen japanischen Philosophen Kitar??o?? Nishida (1870-1945) und ihr Bezug zur Frage nach der Interkulturalität. Nishidas Philosophie ist einerseits _interkulturell orientierte Philosophie_ - entstanden aus der interkulturellen Begegnung zwischen westlicher und japanischer Kultur im Rahmen des modernen Japans - und andererseits bietet sie einen Ansatz zu einer _Philosophie der Interkulturalität_. Der Ansatz gibt einen neuen Blick auf die globalen geschichtlichen Vorgänge frei - gesehen durch die Augen eines außereuropäischen Denkers. Mit Nishidas Philosophie und (...) ihrer geschichtlichen Stellung wird somit die Frage nach der Moderne im interkulturellen Kontext auf neue Weise virulent, so daß sich neue Fragehorizonte für das Denken der Gegenwart ergeben. (shrink)

This Element is a study of how the power of imagination is, according to Kant, supposed to contribute to cognition. It is meant to be an immanent and a reconstructive endeavor, relying solely on Kant's own resources when he tries to determine what material, faculties, and operations are necessary for cognition of objects. The main discourse is divided into two sections. The first deals with Kant's views concerning the power of imagination as outlined in the A- and B- edition of (...) the Critique of Pure Reason. The second focuses on the power of imagination in the first part of the Critique of Judgment. (shrink)

Uncertainty and affect are fundamental and interrelated aspects of the human condition. Uncertainty is often associated with negative affect, but in some circumstances it is associated with positive affect. In this paper, we review different explanations for the varying relationship between uncertainty and affect. We identify “mental simulation” as a key process that links uncertainty to affective states. We suggest that people have a propensity to simulate negative outcomes, which results in a propensity towards negative affective responses to uncertainty. We (...) also propose the existence of several important moderators of this process, including context and individual differences such as uncertainty tolerance, as well as emotion regulation strategies. Finally, we highlight important knowledge gaps and promising areas for future research, both empirical and conceptual, to further elucidate the relationship between uncertainty and affect. (shrink)

In 2015, a flourish of “alarums and excursions” by the scientific community propelled CRISPR/Cas9 and other new gene-editing techniques into public attention. At issue were two kinds of potential gene-editing experiments in humans: those making inheritable germ-line modifications and those designed to enhance human traits beyond what is necessary for health and healing. The scientific consensus seemed to be that while research to develop safe and effective human gene editing should continue, society's moral uncertainties about these two kinds of experiments (...) needed to be better resolved before clinical trials of either type should be attempted. In the United States, the National Academies of Science, Engineering and Medicine convened the Committee on Human Gene Editing: Scientific, Medical and Ethical Considerations to pursue that resolution. The committee's 2017 consensus report has been widely interpreted as “opening the door” to inheritable human genetic modification and holding a line against enhancement interventions. But on a close reading it does neither. There are two reasons for this eccentric conclusion, both of which depend upon the strength of the committee's commitment to engaging diverse public voices in the gene-editing policy-making process. (shrink)

This essay examines the claim “path dependence entails irreversibility” from the point of view of evolutionary biology. I argue that evolutionary irreversibility possesses many faces, sometimes conflicting with path dependence. I propose an account of path dependence that does not rely on irreversibility and explains why it more naturally coexists with the notion of (contingent) irreversibility developed by the Belgian paleontologist Louis Dollo. However, I argue that we should not conceive of this relationship as necessary.

In Jeremy Waldron’s book, The Harm in Hate Speech, it is not always clear whether he argues that hate speech causes harm or whether it constitutes harm. This article considers this uncertainty, concluding that the best understanding of Waldron’s argument is that hate speech tends to cause harm - a weak form of the consequentialist case for its proscription. His argument is not advanced by his apparent reliance on speech-act theory.

This paper begins by observing a tension in the Zhuangzi (or Chuang Tzu). On the one hand, Zhuangzi often advocates radical skepticism and relativism. On the other hand, he often makes a variety of factual claims and endorses and condemns various ways of living, in apparent disregard of any skeptical or relativist considerations. I resolve this tension by suggesting that Zhuangzi does not mean what he says when he advocates skepticism and relativism - that he aims in the apparently skeptical (...) and relativist passages not to convince anyone of the truth of these positions, but rather simply to have a certain sort of anti-dogmatic, therapeutic effect. I support this position with a variety of arguments centered around the idea that Zhuangzi does not feel the need to take seriously that which can be put into words. (shrink)

In this article, the author explores some possible applications of Wittgenstein’s humanistic psychology, epistemology and philosophy of culture for the philosophy of technology, and more particularly, for the question of valuing a possible future technocracy over contemporary democratic systems. Major aspects of the article involve a discussion of some of Wittgenstein’s key views on certainty, cultural relativism, the problem of other minds, and gradual socio-cultural change. In order to examine these problems, the author draws from both a wide range of (...) Wittgenstein’s works, as well as secondary sources in Wittgenstein studies. An analogy is made between socio-cultural change over time and gradual visual loss. The author has incorporated important elements of Wittgenstein’s biography, both as a philosopher and as an engineer and architect, underlining the profound link between his life and thought. (shrink)

What is group well-being? There is, as of yet, shockingly little philosophical literature explicitly aiming to answer this question. This essay sketches some of the logical space of possible answers, and nudges us to seriously consider certain overlooked options. There are several importantly different ways the well-being of a collective or a group could be related to the well-being of the individuals who constitute it: 1) eliminativism, 2) functionalism, 3) partialism, or 4) the independent view. If the relation between individual (...) and collective well-being is either functional or partial, then we face a further question: What is the direction of constitutive dependence? Does the well-being of a group depend upon the well-being of the well-being of the individuals who compose it, or does the well-being of an individual depend upon the well-being of the groups to which they belong? Or both? These questions raise some puzzles that I begin to resolve. I conclude that there might be a wide variety of ways the well-being of a collective obtains, only some of which are related to the well-being of the individuals who are its members. In the end, I hope to vindicate the thought that an injury to one is an injury to all. (shrink)

ABSTRACT This essay calls attention to two blind spots in Power Without Knowledge. First, the book has little to say about the role that political institutions can play in promoting effective democratic governance. Drawing on the “mixed government” tradition, I argue that properly designed institutions can correct for the epistemic deficits that Friedman describes by creating what I call the “pressure to conflict.” Second and more importantly, the book has nothing to say about the role of responsible leadership in a (...) democratic technocracy. Drawing on Max Weber’s analysis of the ethics of responsibility and the ethics of conviction, I argue that responsible leadership can promote judicious technocracy in a dynamic that I call the “spiral of responsibility.” The responsible leader recognizes that to recuse oneself from the exercise of technocratic power is to empower the unscrupulous and irresponsible. According to Weber, any theory of politics that fails to embrace the ethics of responsibility will therefore occupy an uneasy middle ground between quietism and enthusiasm. This, I fear, is where Power Without Knowledge may leave us. (shrink)

In 1989, Susan Wolf convincingly warned of a troublesome consequence that should discourage any movement in American society towards physician-assisted death—a legal backlash against the gains made for limiting life-sustaining treatment. The authors demonstrate that this dire consequence did not come to pass. As physician-assisted suicide gains a foothold in USA and elsewhere, many other slippery slope arguments are being put forward. Although many of these speculations should be taken seriously, they do not justify halting the new practice. Instead, our (...) courts, regulatory agencies, journalists, professional organisations and researchers should carefully monitor and study it as it unfolds, allowing continuous improvement just as our society has done in implementing the practice of limiting life-sustaining treatment. (shrink)

Some worry that offering too much money to participate in medical research can seduce people into participating against their better judgment. These overly attractive offers that impair judgment are often referred to as ‘undue inducements’. The current approach to prevent undue inducement is to limit the size of such offers. The hope is that smaller offers will not be attractive enough to impair judgment. Even if this is true, I argue that we should reject this solution. In Section 1, I (...) go over the problem of undue inducement, and our current approach to preventing it, in more detail. In Section 2, I argue that, like money, therapeutic benefits of medical research may also unduly induce. In Section 3, I argue that the current approach to preventing undue inducement is absurd in the case of therapeutic inducements. In Section 4, I argue that our current approach is analogously problematic in the case of monetary inducements. (shrink)

Thought: A Journal of Philosophy, EarlyView.

I argue that there are some causal relata for which it is indeterminate whether one caused the other. Positing indeterminacy in causation helps us defend contested principles in the logic of causation and makes possible new ways of thinking about the theoretical impact of symmetric causal overdetermination. I close by discussing amendments of current theories of causation that would help explain causal indeterminacy.

Totalitarianism Totalitarianism is best understood as any system of political ideas that is both thoroughly dictatorial and utopian. It is an ideal type of governing notion, and as such, it cannot be realised perfectly. Faced with the brutal reality of paradigmatic cases like Stalin’s USSR and Nazi Germany, philosophers, political theorists and social scientists have … Continue reading Totalitarianism →.

Braitenberg et al.'s view that the cerebellum contributes to multijoint sequences of movement is too narrow to account adequately for results from new anatomical, neurobehavioral, and neuroimaging studies. A broader view is that the cerebellum modulates attention, sensory, motor, and other neural systems in order to accomplish its prime function, which is to learn to predict and prepare for imminent information acquisition, analysis, or action.