The pituitary hormone prolactin (PRL) is best known for its role in the regulation of lactation. Recent evidence furthermore indicates PRL is required for normal reproduction in rodents. Here, we report on the insertion of two transposon-like DNA sequences in the human prolactin gene, which together function as an alternative promoter directing extrapituitary PRL expression. Indeed, the transposable elements contain transcription factor binding sites that have been shown to mediate PRL transcription in human uterine decidualised endometrial cells and lymphocytes. We (...) hypothesize that the transposon insertion event has resulted in divergent (pituitary versus extrapituitary) expression of prolactin in primates, and in differential actions of pituitary versus extrapituitary prolactin in lactation versus pregnancy respectively. Importantly, the TE insertion might provide a context for some of the conflicting results obtained in studies of PRL function in mice and man. (shrink)

A Question of Voice: Philosophy and the Search for Legitimacy offers an explicit and comprehensive consideration of voice as a complex of rethinking aspects of the history of philosophy through issues of power, as well as contemporary issues that include and involve the desire for and the dynamics of legitimacy, for individuals and communities. By identifying voice as a significant theme and means by which and through which we might better engage some important philosophical questions, Ron Scapp hopes to expand (...) traditional philosophical discussion and discourse regarding questions about validity, legitimacy, empathy, and solidarity. He offers an innovative perspective that is informed and guided by multiculturalism, ethnic studies, queer studies, feminism, and thinkers and critics such as bell hooks, Barbara Christian, Angela Davis, Jacques Derrida, Michel Foucault, among others. A Question of Voice is an American investigation, but also suggests questions that emanate from contemporary continental thought as well as issues that arise from transnational perspectives-an approach that is motived by doing philosophy in an age of multiculturalism. (shrink)

Researches over many years have examined whether levonorgestrel emergency contraception has a postfertilization effect. In a recent article in the Catholic Health Association’s journal Health Progress, Sandra Reznik, MD, asserts that “levonorgestrel acts to prevent pregnancy before, and only before, fertilization occurs.” A companion article by Ron Hamel, PhD, argues for the moral certainty that Plan B is not an abortifacient. Reznik fails to address the principal model supporting a potential postfertil­ization mechanism of action, specifically, that preovulatory administration of levonorgestrel (...) disrupts the delicate ratio of estrogen and progesterone essential to healthy endometrial development and induces the equivalent of luteal phase insufficiency, thereby jeopardizing implantation. Hamel’s argument for moral certitude is similarly inadequate. This article critically reviews both articles and the sources on which they rely. National Catholic Bioethics Quarterly 10.4 : 741–772. (shrink)

A good deal of moral criticism employed in everyday life associates, in a variety of ways and in varying degrees of complexity, selfish behaviour and attitudes with a deficiency in what Dr Leavis calls ‘ethical sensibility’. A primitive ethical sensibility is a species of ignorance; it is to be unperceptive, muddled, superficial, undiscriminating and slipshod in one's understanding and appreciation of the nature and quality of one's own and other people's experience. It might involve, for example, being afflicted with sentimentalism; (...) perceiving people through a distorting medium of stereotypes or impressionistically; being dominated by wishful thinking in the Freudian sense; holding beliefs on the basis of hearsay, authority, or because it suits one to hold them; being immersed in situations and relationships whose continued existence requires self-deception; having the sense of one's own worth be wholly dependent upon the opinions of others. A developed ethical sensibility, on the other hand, includes what Professor Peters and others believe to be among the defining characteristics of rationality—impartiality; a caring for clarity, evidence, relevance, consistency and sincerity; a willingness to question authorities, tradition and one's own motives; refusing to be tempted by the cosiness of easy certainties and the stock response. The content of such a sensibility will, of course, depend upon the context in which reason is employed, and attempts to describe the content must take the form of a detailed discussion of particular cases. (shrink)

This is not a random collection of essays, but a book on a single theme. Written by separate hands, mainly by literary critics at Cambridge, it was planned as a whole and executed with a common purpose: to produce the first literary study of the English moralists of the seventeenth century to the beginning of the twentieth. The authors share two convictions: they believe that the study of literature demands an understanding of whatever moral philosophy is embodied in it; and (...) they believe that philosophical writings are capable of being tested by the techniques of literary criticism. In this book, such works as Bacon's Advancement of Learning, Hobbes's Leviathan, and Hume's Enquiries are viewed as whole works, not as repositories of philosophical propositions, nor as episodes in the history of English thought. (shrink)

A deep and precise introduction to the philosophy of religion that is also remarkably clear and insightful. The author has a conversation with the student and uses concrete examples to explain often abstract concepts and issues.

ABSTRACT It has become standard to conceive of metalinguistic disagreement as motivated by a form of negotiation, aimed at reaching consensus because of the practical consequences of using a word with one content rather than another. This paper presents an alternative motive for expressing and pursuing metalinguistic disagreement. In using words with given criteria, we betray our location amongst social categories or groups. Because of this, metalinguistic disagreement can be used as a stage upon which to perform a social identity. (...) The ways in which metalinguistic disagreements motivated in this way diverge in character from metalinguistic negotiations are described, as are several consequences of the existence of metalinguistic disagreements motivated in this way. (shrink)

Many assume that theories of distributive justice must obviously take people’s lifetimes, and only their lifetimes, as the relevant period across which we distribute. Although the question of the temporal subject has risen in prominence, it is still relatively underdeveloped, particularly in the sphere of health and healthcare. This paper defends a particular view, “momentary sufficientarianism,” as being an important element of healthcare justice. At the heart of the argument is a commitment to pluralism about justice, where theorizing about just (...) principles demands paying attention to the role particular goods play in our lives. This means that different approaches to the temporal subject—as well as other relevant issues—may be appropriate for different goods, including different goods within healthcare. In particular, the paper discusses two central goods targeted by healthcare: life-saving and pain relief. The view is offered as complementary to, rather than competitive with, lifetime approaches. As such, the paper finishes by considering how a pluralist approach, which engages both with people’s lives as a whole and with their states at particular moments, can reconcile the potentially competing claims in healthcare that emerge from these two perspectives. (shrink)

Stephen Davies presents a fascinating exploration of the idea that art, and our aesthetic sensibilities more generally, should be understood as an element in human evolution. He asks: Do animals have aesthetics? Do our aesthetic preferences have prehistoric roots? Is art universal? What is the biological role of aesthetic and artistic behaviour?

I review and reconsider some of the themes of ‘Two notions of necessity’ (Davies and Humberstone, 1980) and attempt to reach a deeper understanding and appreciation of Gareth Evans’s reflections (in ‘Reference and contingency’, 1979) on both modality and reference. My aim is to plot the relationships between the notions of necessity that Humberstone and I characterised in terms of operators in two-dimensional modal logic, the notions of superficial and deep necessity that Evans himself described, and the epistemic notion (...) of a priority. (shrink)

When A utters a declarative sentence in a context to B, typically A can mean a proposition by the sentence, the sentence in context literally expresses a proposition, there are propositions A and B can agree the sentence literally expressed, and B can acquire knowledge from this testimonial exchange. In recent work on linguistic communication, each of these four platitudes has been challenged, and on the same basis: viz. on the ground that exactly which proposition the sentence expressed in context (...) is not discernible given the information provided by the context. I argue that, even if this is true, there will be propositional parts of the proposition expressed by the sentence in context which can be identified and that, consequently, the partial understanding afforded by the existence of such identifiable parts undermines the soundness of the arguments against the platitudes. (shrink)

This editorial critically engages with the understanding of openness by attending to how notions of presence and absence come bundled together as part of efforts to make open. This is particularly evident in contemporary discourse around data production, dissemination, and use. We highlight how the preoccupations with making data present can be usefully analyzed and understood by tracing the related concerns around what is missing, unavailable, or invisible, which unvaryingly but often implicitly accompany debates about data and openness.

Psychiatry uncomfortably spans biological and psychosocial perspectives on mental illness, an idea central to Engel's biopsychosocial paradigm. This paradigm was extremely ambitious, proposing new foundations for clinical practice as well as a non-reductive metaphysics for mental illness. Perhaps given this scope, the approach has failed to engender a clearly identifiable research programme. And yet the view remains influential. We reassess the relevance of the biopsychosocial paradigm for psychiatry, distinguishing a number of ways in which it could be (re)conceived.

The Genre Legong is a secular (balih-balihan) Balinese dance genre (Anon. 1971).[1] Though originally associated with the palace,[2] legong has long been performed in villages, especially at temple ceremonies, as well as at Balinese festivals of the arts. Since the 1920s, abridged versions of legong dances have featured in concerts organized for tourists and in overseas tours by Balinese orchestras. Indeed, the dance has become culturally emblematic, and its image is used to advertise Bali to the world. Traditionally, the dancers (...) are three young girls; the servant (condong), who dances a prelude, and two legong. All wear elaborate costumes of gilded cloth with ornate accessories and frangipani-crowned headdresses.[3] The core repertoire consists of about fifteen dances (some of which are now lost), ranging in their longest versions from thirty to sixty minutes. Some of these are narrative, while others are abstract or general representations of nature, birds, insects, or plants. Those that involve narratives are, nevertheless, highly stylized, and the presentation of the drama is always secondary to the beauty of the dance. The genre is regarded as a treasury of the movements for Balinese women’s dance, and no dancer’s training is complete if she lacks a solid grounding in legong. The dance is accompanied by a gamelan of twenty-five or more players.[4] Though the legong dance remains popular in areas of traditional strength, and despite efforts to revive it, it is generally in decline (Davies 2006). (shrink)

Thinking is special. There is nothing quite like it. Thinking.

This paper resolves a paradox concerning colour constancy. On the one hand, our intuitive, pre-theoretical concept holds that colour constancy involves invariance in the perceived colours of surfaces under changes in illumination. On the other, there is a robust scientific consensus that colour constancy can persist in cerebral achromatopsia, a profound impairment in the ability to perceive colours. The first stage of the solution advocates pluralism about our colour constancy capacities. The second details the close relationship between colour constancy and (...) contrast. The third argues that achromatopsics retain a basic type of colour constancy associated with invariants in contrast processing. The fourth suggests that one person-level, conscious upshot of such processing is the visual awareness of chromatic contrasts ‘at’ the edges of surfaces, implicating the ‘colour for form’ perceptual function. This primitive type of constancy sheds new light on our most basic perceptual capacities, which mark the lower borders of representational mind. (shrink)

There is an ongoing increase in the use of mobile health technologies that patients can use to monitor health-related outcomes and behaviours. While the dominant narrative around mHealth focuses on patient empowerment, there is potential for mHealth to fit into a growing push for patients to take personal responsibility for their health. I call the first of these uses ‘medical monitoring’, and the second ‘personal health surveillance’. After outlining two problems which the use of mHealth might seem to enable us (...) to overcome—fairness of burdens and reliance on self-reporting—I note that these problems would only really be solved by unacceptably comprehensive forms of personal health surveillance which applies to all of us at all times. A more plausible model is to use personal health surveillance as a last resort for patients who would otherwise independently qualify for responsibility-based penalties. However, I note that there are still a number of ethical and practical problems that such a policy would need to overcome. The prospects of mHealth enabling a fair, genuinely cost-saving policy of patient responsibility are slim. (shrink)

post hos elefantorum fulgentium formidandam speciem et truculentos hiatus uix mentes pauidae perferebant; ad quorum stridorem odoremque et insuetum aspectum magis equi terrebantur. COKNELISSEN, Mnemosyne, xiv , 280, comments: ‘Non intellego fulgentium. Minime audiendus est Wagnerus, qui fulgentes elephantes dictos esse contendit ob cutem glabram. Corrigendum puto ingentium. Porro non satis intellego quomodo hiatus elefantorum militibus pauorem incutere potuerit. Wagnerus, qui omnia con-coquere solet, interpretatur proboscidas. Nescio an scripserit A. barritus.’.

The honour of being the first to teach philosophy in Australia belongs to the Congregationalist minister Barzillai Quaife (1798–1873), in the 1850s, but teaching philosophy did not formally begin until the 1880s, with the establishment of universities (Grave 1984). -/- Two approaches have dominated Western philosophy in Australia: Idealism and materialism. Idealism was prevalent between the 1880s and the 1930s, but dissipated thereafter. It was particularly associated with the work of the first professional philosophers in Australia, such as Henry Laurie (...) (1837–1922), Francis Anderson (1858–1941), William Mitchell (1861–1962) (who rejected the label) and a second generation including W. R. Boyce Gibson (1869–1935). Idealism in Australia often reflected Kantian themes, together with the British, particularly Scottish, revival of interest in Hegel through the work of the ‘Absolute Idealists’ T. H. Green (1836–1882), F. H. Bradley (1846–1924) and Henry Jones (1852–1922), the latter of whom conducted a popular lecture tour of Australia (Boucher 1990). -/- A number of the early New Zealand philosophers, including Duncan MacGregor (1843–1906), William Salmond (1835–1917), and Francis W. Dunlop (1874–1932) were educated in the Idealist tradition and were influential in their communities, but produced relatively little. William Anderson (1889–1955), at Auckland, brother of John at Sydney, was the only New Zealand philosopher that seemed to retain Idealist views. -/- In Australia, materialism gained prominence through the work of John Anderson, who arrived in Australia in 1927, and continues to be influential. John Anderson had been a student of Henry Jones, who can be said to have influenced both strands of Australian philosophical thought. (shrink)

Kant distinguishes between ‘active’ and ‘passive’ citizens and holds that only the former are civilly self-sufficient and possess rights of political participation. Such rights are important, since for Kant state institutions are a necessary condition for individual freedom. Thus, only active citizens are entitled to contribute to a necessary condition for the freedom of each. I argue that Kant attributes civil self-sufficiency to those who are not under the authority of any private individual for their survival. This reading is more (...) textually grounded than the dominant reading, which understands civil self-sufficiency in terms of economic relations alone. I further argue that Kant was interested in relations of authority because he was concerned to eliminate certain forms of corruption. This indicates that Kant’s contested distinction between active and passive citizens was a response to a key problem of any account of public lawgiving. (shrink)

Training for members of research ethics committees varies from state to state in Europe. To follow this up, the European Forum for Good Clinical Practice organised a workshop in March 2007 to explore these issues and look for solutions. This article summarises the discussion, providing ways forward to develop REC training.

In this paper I suggest that music and dance of an artful kind could pre-date the emergence of our species by several hundred thousand years. Our progenitor, H. heidelbergensis, had the necessary physiological resources and social capacities. And she inherited older modes of moving and vocalizing that could have laid the foundations for dance and music. Admittedly, for her, these artistic activities would have been more about sharing and expressing emotions than about symbolizing abstract ideas or conveying complex thoughts. But (...) that is something for which song and dance are ideally suited. Accordingly, the common assumption made by many paleoarchaeologists in discussions of the origins of art and of psychological modernity — that art is a distinctively sapiens attribute presupposing the kind of complex mentality that may be unique to our species — is mistaken. As well, there are some philosophical morals about the nature of art to be teased from the facts of its ancient origin. (shrink)

Priorities in Medical Research was published in 1988 by a select committee of the House of Lords. The report ushered in an era of NHS research and development that lasted from 2001 to 2006. The inquiry's origins lay in concerns about academic medicine in the United Kingdom, yet PMR gave relatively little attention to this subject. Instead the report focused critically on the disconnect between the Department of Health and the NHS in R & D. This, the committee argued, had (...) led to the neglect of research into health services and public health. To sidestep the report's unwelcome proposal for a National Health Research Agency, the department eventually grafted R & D management onto structures created as part of wider NHS reforms. The Medical Research Council successfully pursued a strategy of keeping the committee's attention away from sensitive aspects of its own programme. The final focus of PMR was shaped by an alignment between committee members with an industrial view of research and champions of health services research. The actions of the various actors involved are interpreted using elite models of the state, and the applicability of these models is critically examined. (shrink)

Being human while trying to scientifically study human nature confronts us with our most vexing problem. Efforts to explicate the human mind are thwarted by our cultural biases and entrenched infirmities; our first-person experiences as practical agents convince us that we have capacities beyond the reach of scientific explanation. What we need to move forward in our understanding of human agency, Paul Sheldon Davies argues, is a reform in the way we study ourselves and a long overdue break with (...) traditional humanist thinking. Davies locates a model for change in the rhetorical strategies employed by Charles Darwin in _On the Origin of Species_. Darwin worked hard to anticipate and diminish the anxieties and biases that his radically historical view of life was bound to provoke. Likewise, Davies draws from the history of science and contemporary psychology and neuroscience to build a framework for the study of human agency that identifies and diminishes outdated and limiting biases. The result is a heady, philosophically wide-ranging argument in favor of recognizing that humans are, like everything else, subjects of the natural world—an acknowledgement that may free us to see the world the way it actually is. (shrink)

The Journal of Aesthetics and Art Criticism, Volume 78, Issue 1, Page 75-79, Winter 2020.

Legal pluralism refers to the idea that in any one geographical space defined by the conventional boundaries of a nation state, there is more than one law or legal system. This article examines several aspects of legal pluralism focusing on the relationship between the empirical facts of pluralism and its conceptual foundations. Variety of factors produce the perception of legal pluralism, which is reflected in intensified interest in the concept in contemporary scholarship. Legal philosophy and sociological approaches to law often (...) still occupy quite separate scholarly terrains. Legal pluralism has been identified as a fruitful area for constructive engagement between legal philosophy and the sociology of law. This article emphasizes the fact that with the decline of nation states as the locus of political and legal power, it seems inevitable that traditional state-centered legal philosophy must give way to a different paradigm, which recognizes the plurality of law. (shrink)