Child maltreatment not only leads to epigenetic changes, but also increases the risk of related behavioral deficits and mental disorders. These issues presumably are most closely associated with epigenetic changes in the brain, but epigenetic changes in peripheral tissues like blood are often examined instead, due to their accessibility. As such, the reliability of using the peripheral epigenome as a proxy for that of the brain is imperative. Previously, our lab has found aberrant methylation at the Brain-derived neurotrophic factor gene (...) in the prefrontal cortex of rats following aversive caregiving. The current study examined whether aversive caregiving alters Bdnf DNA methylation in the blood compared to the prefrontal cortex. It was revealed that DNA methylation associated with adversity increased in both tissues, but this methylation was not correlated between tissues. These findings indicate that group trends in Bdnf methylation between blood and the brain are comparable, but variation exists among individual subjects. (shrink)

To date, little is known about when and to what degree science students begin to participate in authentic scientific graphing practices. This article presents the results of a series of studies on the production, transformation, and interpretation of graphical representation from Grade 8 to professional scientific practice both in formal testing situations and in the course of field/laboratory work. The results of these studies can be grouped into two major areas. First, there is a discontinuity in the graph-related practices that (...) marks a boundary between people who engage in work that requires them to transform data into graphical representations and people who do not have such experiences. Second, the didactic practices of high school textbooks and university lectures exhibit a marked discontinuity relative to graphing practices in scientific journals. Graphs used in didactic circumstances may be associated with students’ difficulties in interpreting “real data.” It appears that school teachers and university professors do little to put their students on trajectories of increasing participation in authentic scientific graphing practices. (shrink)

This handbook of Anabaptism and Spiritualism provides an informative survey of recent scholarship on the Radical Reformation, from the 1520s to the end of the eighteenth century. Each chapter offers a narrative summary that engages current research and suggests directions for future study.

In this study, we take up L. S. Vygotsky’s challenge to study learning and development in terms of categories, irreducible units that preserve the characteristics of the whole. One such category is experiencing [pereživanie], a process that integrates over the relation of person and environment. Using a case study from Iceland, we theorize the process of “becoming as a teacher-in-a-village school” in terms of experiencing [pereživanie]. The case describes a stage of development in the life of a person who becomes (...) a teacher and then experiences a developmental trajectory very different from his previous life as a fisherman. This is an aspect of teacher education that is hardly described in the teacher education literature which tend to be concerned with events after a person has entered a professional program or after a person has begun teaching. We discuss the implications of taking experiencing [pereživanie] as the developmental unit for theory and the practice of teacher education and development. (shrink)

This essay aims to describe and analyse the important contributions of the Chinese philosopher and diplomat P.C. Chang concerning the 1948 Universal Declaration of Human Rights (the UDHR). After a brief biographical sketch, Chang’s main contributions will be presented and discussed. A study of Chang’s contributions in this context may also highlight the ethical potential of the UDHR and its great relevance to global ethics and world politics today.