Hypocretin regulates brain reward function and cocaine consumption in rats. The hypocretinergic (Hcrt) system is implicated in energy homeostasis, feeding and sleep regulation. Hypocretinergic cell bodies are located in the lateral hypothalamus (LH) and project throughout the brain. The aim of the present studies was to investigate the role of the Hcrt system in regulating brain reward function and the reinforcing properties of cocaine in rats. Intracranial self-stimulation (ICSS) thresholds provide an accurate measure of brain reward function in rats. Here (...) we show that a single injection of Hcrt-1 (5 µg icv) induced persistent, long-lasting elevations in ICSS thresholds in drug-naïve rats. Indeed, Hrct-1 elevated ICSS thresholds for 36 h, with peak elevations between 6 and 12 hours after injection. Hrct-1-induced threshold elevations were attenuated by an antibody known to neutralize the binding of hcrt-1 to its receptors. Taken together, these observations suggest that Hrct-1 negatively regulates brain reward function in rats. Because Hrct-1 negatively regulates brain reward function, we hypothesized that it may attenuate the increased brain reward function usually observed after cocaine consumption, and thereby alter cocaine self-administration behavior. A daily injection of Hrct-1 (1 µg icv), for 4 consecutive days, slightly increased cocaine self-administration (0.25 mg/infusion) in rats. Overall, these data demonstrate that Hrct-1 negatively regulates brain reward function, and as such may indirectly alter cocaine self-administration. Given the well-established role of hypocretin neurons in regulating feeding behavior and sleep, we hypothesize that hypocretinergic regulation of brain reward function may provide a mechanism by which appropriate and competing behaviors (e.g. sleep or feeding) may be engaged to maintain energy homeostasis. (shrink)

This essay offers a critique of the culture of specio-vocationalism in American higher education by first drawing on Edmund Husserl’s conception of “world” and connecting this notion to education conceived as a “world-disclosing” activity. The essay will then give an account of how the trends of vocationalization and specialization manifest themselves in contemporary university culture, and how they work together to “de-world” the lives of our students and deprive them of possibilities that are part of what it means to (...) be human. After showing how this impoverishment undermines the world-disclosing function of higher education, the essay will then suggest one way to counter this “de-worlding of world”: the teaching of the situated finitude of the human condition by reminding our students that our knowledge or sense of the world is always only partial. It is this realization that has the potential of placing our students once again before the vastness of the world in wonder and curiosity. In this realization they will gain a better sense of the world as a distant horizon still to be explored in all of its inexhaustible complexity and meaning. At the same time, coming to grips with their own ignorance will imbue them with an intellectual humility that will shield them not only from their own finitude, but the finitude of others as well. (shrink)

This chapter contains section titled: Introductory Remarks The Cartesian Background Impressions and Ideas Passions as Reflective Impressions Direct and Indirect Passions Association and the Individuation of Passions Perception and Perceiving Passions and Moral Sentiments Notes References Further reading.

This paper provides a materialist approach to defining gender identity.

This article considers whether there is a specific demand for migrant domestic workers in the UK, or for workers with particular characteristics that in theory could be met by citizens. It discusses how immigration status can make it easier not only to recruit domestic workers, but also to retain them. `Foreignness' may also make the management of the employment relation easier with employers anxious to discover a coincidence of interest with the worker. Employers are not only looking for generic `foreignness' (...) however, but typically also seek particular nationalities or ethnicities of worker, which can raise difficulties for agencies who are not allowed to discriminate on the basis of `race'. (shrink)

Recent works have invited us to look into how modes of secularism influence the shape of ‘modern’ religion. This literature has remained quite state-centred, paying less attention to how concepts of secularism migrate from one national context to another. This article seeks to investigate these transnational dynamics. More specifically, it aims to explore this process of travelling through the contemporary writings of the Quebec-based essayist Djemila Benhabib. The article approaches her writings as ‘travelogues’: a genre which acts as an invitation (...) to focus on the ‘travelling’ dimension and politics of location of her accounts. A special emphasis is put on analysing how her writings are vehicles for the travel of gendered visions of secularism from France to Quebec. Ultimately, the article argues that taking these processes of transnational migrations into consideration is necessary to better locate and understand the politics of national debates. (shrink)