BackgroundBreast cancer patients are at elevated risk of depression during treatment, thus provoking the chance of poor clinical outcomes. This retrospective cohort study aimed to investigate whether integrating Chinese herbal medicines citation into conventional cancer therapy could decrease the risk of depression in the long-term breast cancer survivors.MethodsA cohort of patients aged 20–70 years and with newly diagnosed breast cancer during 2000–2008 was identified from a nationwide claims database. In this study, we focused solely on survivors of breast cancer at (...) least1 year after diagnosis. After one-to-one matching for age, sex, and baseline comorbidities, breast cancer patients who received and did not receive CHM treatment were enrolled. The incidence rate and hazard ratio citation for depression between the two groups was estimated at the end of 2012. A Cox proportional hazard model was constructed to examine the impact of the CHM use on the risk of depression.ResultsDuring the study period, the incidence rate of depression was significantly lower in the treated cohort than in the untreated cohort [8.57 compared with 11.01 per 1,000 person-years citation], and the adjusted HR remained significant at 0.74 in a Cox proportional hazards regression model. The corresponding risk further decreasing to 43% among those using CHM for more than 1 year.ConclusionFinding from this investigation indicated that the lower risk of depression observed in breast cancer patients treated with CHM, suggesting that CHM treatment should be considered for disease management toward breast cancer. Yet, the optimal administered dose should be determined in further clinical trials. (shrink)

ObjectivePrevious studies have demonstrated altered brain activity in strabismic amblyopia. In this study, low-frequency repetitive transcranial magnetic stimulation was applied in children with strabismic amblyopia after they had undergone strabismus surgery. The effect of rTMS was investigated by measuring the changes of brain features using the amplitude of low-frequency fluctuation.Materials and MethodsIn this study, 21 SA patients were recruited based on their age, weight, and sex. They all had SA in their left eyes and they received rTMS treatment one month (...) after strabismus surgery. Their vision before and after surgery were categorized as pre-rTMS and post-rTMS. All participants received rTMS treatment, underwent magnetic resonance imaging, and their data were analyzed using the repeated measures t-test. The team used correlation analysis to explore the relationship between logMAR visual acuity and ALFF.ResultsPre- versus post-rTMS values of ALFF were significantly different within individuals. In the POT group, ALFF values were significantly decreased in the Angular_R, Parietal_Inf_L, and Cingulum_Mid_R while ALFF values were significantly increased in the Fusiform_R and Frontal_Inf_Orb_L compared to the PRT stage.ConclusionOur data showed that ALFF recorded from some brain regions was changed significantly after rTMS in strabismic amblyopes. The results may infer the pathological basis of SA and demonstrate that visual function may be improved using rTMS in strabismic amblyopic patients. (shrink)

This paper discusses the philosophy of Zhu Xi, "a sub-Shu" concept, and that "a sub-Shu," Zhu Xi's philosophy in the concept of moral ethics, metaphysics, cosmology and so many different face. By "a sub-Shu," Zhu Xi's view, ethics has its objective basis for its endless from the Heaven. And this seems to be constructed for the contemporary world, to provide some contribution to the work ethic.

More and more studies showed that strabismus is not simply an ocular disease, but a neuro-ophthalmology disease. To analyze potential changes in brain activity and their relationship to behavioral performance in comitant strabismus patients and healthy controls. Our study recruited 28 patients with comitant strabismus and 28 people with matched weight, age range, and sex ratio as healthy controls. Using resting-state functional magnetic resonance imaging, we evaluated fALFF to compare spontaneous brain activity between comitant strabismus and healthy controls. We did (...) hospital anxiety and depression scale questionnaires for these patients. We found significantly lower fALFF value in comitant strabismus patients compared with controls in the left frontal superior medial gyrus and the right middle cingulum. In the latter region, fALFF was significantly negatively correlated with the hospital anxiety and depression scale, as well as the duration of disease. Receiver operating characteristic curve analysis indicated that the fALFF method has clear potential for the diagnosis of comitant strabismus patients. These results revealed abnormal spontaneous activity in two brain regions of comitant strabismus patients, which may indicate underlying pathologic mechanisms and may help to advance clinical treatment. (shrink)

本书从唐朝一桩谋杀案讲起,通过大量生动的历史案例,运用翔实考据和缜密逻辑,揭示了上溯至春秋时代的中国经典文化,包括春秋"一经三传",论语老子等,是如何在皇权政治下被扭曲成了权力的工具的.

PurposeTo investigate spontaneous brain activity in patients with dry eye and healthy control using the fractional amplitude of low frequency fluctuation technique with the aim of elucidating the relationship between the clinical symptoms of DE and changes in brain function.Material and MethodsA total of 28 patients with DE and 28 matched healthy volunteers were enrolled. Resting-state functional magnetic resonance imaging scans were performed in both groups. Then all subjects were required to complete a comprehensive Hospital Anxiety and Depression Scale. Receiver (...) operating characteristic curve analysis was used to evaluate the differences in fALFF values between the two groups and their diagnostic value. Linear correlations between HADS and fALFF values in different brain regions of DE patients were analyzed using the Pearson correlation coefficient.ResultsPatients with DE had significantly higher fALFF values in the left calcarine sulcus than the HC group, while fALFF values in the bilateral middle frontal gyrus and right MFG/right inferior frontal gyrus were significantly lower in DE patients than in HC group. fALFF values had a high diagnostic value for differentiating patients with DE from the HC group. Right MFG and right MFG/IFG were significantly correlated with HADS values.ConclusionOur study found that DE mainly involved functional disorders in the brain areas of the left CS, bilateral MFG and right MFG/right IFG, which helped us to find possible clinical features of DE disease and reflected the potential pathological mechanism of DE. (shrink)

ḥeleḳ 1. Kolel azharot ṿe-liḳuṭe dinim neḥutsim mi-Shu. ʻa. ṿe-aḥaronim ... -- ḥeleḳ 2. Ka-n.l. be-hosafat harbeh segulot le-yirʼat Shamayim ule-farnasah ... .

본고에서는 漢代의 세계관에서 經學과 讖緯의 관계를 어떻게 접근할 것인가 하는 문제의식에서 출발한다. 참위의 사상은 黃老學과 天人感應說의 기조 속에서 음양오행의 원리를 활용하여 儒家의 경전을 해석한 특수한 형태의 經學에 속한다. 그 대표적인 책이 『역위』이다. 『역위』에서는 『주역』의 象數易學的 특징인 取象運數의 방식을 활용하여 宇宙의 도식을 그려내었다. 우주는 元氣의 원천으로부터 氣化의 작용으로 흘러가는 세계의 실재를 시공간성으로 표현한 것이다. 우주의 도식은 元氣의 본원과 太易의 범주에 입각하여 세계의 태동과 삼라만상이 생성하는 일련의 과정을 표상한 것이다. 이러한 과정은 太易, 太初, 太始, 太素의 四太說로 설명된다. 이 일련의 과정은 取象의 방식에 (...) 따라 運數의 원리를 활용하여 천지의 개벽과 그 현상을 상징한다. 천지의 틀은 우주의 일부분으로서 시간의 제한성과 공간의 한계성을 지닌 세상의 경계이다. 천지의 개벽은 시간의 연속성에 따라 공간의 통일성을 이루고 공간의 통일성 속에서 시간의 연속성이 진행되는 과정이다. 우주의 본원으로부터 만물이 생성되는 일련의 과정에서 수1의 형식은 분화의 방식으로 작동한다. 이 과정은 1의 數가 발용의 기점이 된다. 1의 수는 실체가 존재하는 상태나 형식을 가리킨다. 1과 2는 서로 대립하는 과정에서 3의 조화로 통일된다. 3의 조화란 3 전체에서 1이 본체가 되고 1의 본체에 2의 기능이 포함되어있다. 그러므로 천지의 시공간적 개벽에는 삶의 旅程에서 앞서 존재하는 경험적 축적을 통해 형성된 인간의식이 담겨있다. 이는 象과 數의 매체를 통해 세계에 대한 앞선 공통적 경험을 나타내는 先驗主義的 성격을 지닌다. 따라서 『역위』의 太易元氣觀에는 유한의 세계에서 무한의 우주를 직관적으로 체험하는 삶의 命運이 투영되어 있다. 여기에는 생명력이 작동하는 방식에 따라 우주 전체의 시공간적 과정 속에서 공동체의 가치화와 가치의 공동체화가 통합되는 인간의식의 차원이 자리잡고 있다. (shrink)

本书收集了一些与“科学”有关的论文、评论和书评。包括《论第二种科学》、《科学与知性》、《反科学与伪科学》等54篇文章。.