The plurality and complexity of modern science and technology require the research institutions in universities, government and even the private sector to engage in a plurality of activities, from basic to applied science, from graduate education to extension work and teacher-training. They should also be stimulated to diversify their sources of funds, from government to private companies, non-profit foundations and paying clients and students. Specialisation will take place, is necessary, and should grow through a combination of external incentives and internal (...) drive. Scientific research and development, to remain alive, should take place in a highly internationalised and competitive environment for resources, prestige and recognition. And the leading scientists should be also entrepreneurs of this enterprise for the promotion of the growth of knowledge. (shrink)