Three apparently unrelated developmental processes – mammalian myogenesis, the choice of neural fate and sex determination in Drosophila – are controlled by a common mechanism. Most of the genes governing these processes encode transcriptional factors that contain the helix‐loop‐helix (HLH) motif. This domain mediates the formation of homo‐ or heterodimers that specifically bind to DNA through a conserved basic region adjacent to the HLH motif. Dimers differ in their affinity for DNA and in their ability to activate transcription from HLH (...) binding‐site containing promoters. In addition, the activity of HLH proteins is inhibited by dimerization with another class of HLH proteins that lack a basic domain entirely or have an altered one. These structural properties provide a molecular mechanism to explain the synergistic and antagonistic functional relations among the HLH encoding genes that control several developmental pathways. (shrink)

El presente trabajo pretende mostrar la convergencia y continuidad, tanto de temática como de sentido, de dos obras centrales de María Zambrano publicadas en el año 1939 desde el análisis de dos categorías, realismo y racionalismo, con las que se identifica a España y el resto de Europa respectivamente. Así mismo, se busca poner de manifiesto que si bien para la pensadora el racionalismo desemboca en la angustia del sujeto moderno y contemporáneo por llevar asociada la forma del sistema, encontrará (...) en el realismo y estoicismo, más característicos de la tradición hispana, la posible salida a esta angustia en la que se halla Europa a la altura de 1939. (shrink)

En las coordenadas de la globalización, la crisis del Estado provoca un debilitamiento progresivo de la ciudadanía y de la democracia. La globalización encuentra un sólido aliado en la dispersión institucional propiciada por el modelo del Estado-nación. Por eso, la supervivencia del constitucionalismo en cuanto compromiso axiológico sustantivo desemboca hoy más que nunca en el ideal cosmopolita. Pero el cosmopolitismo constitucional no puede cifrarse en la reducción de la pluralidad a una homogeneidad artificial y forzada. Frente a la vieja y (...) ya caduca imagen de la constitución como cúspide de un ordenamiento jurídico autárquico y autosuficiente, reivindicamos una constitución como momento articulador de complejas redes de normas interdependientes, capaz de evitar que las exigencias fácticas dé los cambiantes flujos normativos transnacionales vulneren las exigencias normativas de los valores constitucionales. (shrink)

This article argues that New Granadian and Co-lombian leaders examined models of material and intellectual progress in the United States and in their neighboring countries within the hemisphere. For many Spanish-Americans, the material progress already achieved by the United States and the North Atlantic overall was an idealized end, and they looked at some U.S. institutions as potential templates. As for the means to meet such an idealized end, influential people in New Granada and Colombia found among their neighboring countries (...) a more pragmatic set of experiences that would help them foster progress in their own right. Over the second half of the nineteenth century, and more acti-vely when turning into the twentieth, some Colombian leaders sought to follow the example of countries such as Argentina, one of the front-runners of Latin American contemporary progress. (shrink)

En nuestros días las teorías cosmopolitas han experimentado una revitalización significativa al albur de la intensificación de las relaciones humanas que ha propiciado el fenómeno de la globalización. En las últimas décadas, particularmente desde la caída del Muro de Berlín, se ha registrado un florecimiento de las tesis cosmopolitas que aspiran a ofrecer un modelo teórico desde el que comprender y transformar la realidad en esta era de apertura y de creciente interdependencia que inaugura la globalización. En este trabajo realizamos (...) una aproximación histórica y conceptual al cosmopolitismo, abundando en las causas de su actual auge y, tras analizar los elementos que conforman el fenómeno de la globalización, que determina un tránsito desde la primera a la segunda modernidad, se formula una propuesta humanista e ilustrada de un _cosmopolitismo gradual_, una concepción realista cosmopolita que permita trascender la estatalidad mediante la implementación de formas de gobernanza multinivel. (shrink)

This article analyses the evolutionist discourses on the senses that emerged in the late 19th century, when theories on the evolution of species were in full sway. Drawing on newspapers, essays and medical literature, this article aims to set face to face the two currents of thought that I have identified regarding sensory evolution: the one that stressed the value of the progressive specialisation of the senses as evidence for human evolution mainly supported by Max Nordau, and the one which (...) regarded the sensory regrouping, exemplified by the phenomenon of synaesthesia, as the true symptom of evolution, strongly supported by Victor Segalen. A close examination of their arguments will provide clues concerning their relative position vis-à-vis the theory that stressed the exceptional nature of humankind among all living beings. Based on newspapers, essays and medical literature, this paper, which straddles several fields (history of science, philosophy, cultural history and aesthetics) aims to set both positions face to face, examining their arguments in detail and establishing their genealogies. This will lead to a better understanding of the scope and range of evolutionist discourses in the fin de siècle culture and on their impact upon artistic practices. (shrink)

RESUMEN: Esta era de la globalización es, como Beck ha apuntado, la era del riesgo global, que se caracteriza por el creciente nivel de riesgo en el manejo de los medios técnicos que amenaza la preservación del planeta y la supervivencia de la especie. En ese contexto, resulta cada vez más notoria la insuficiencia de un modelo de comprensión de los derechos humanos vinculado a la primera modernidad, que concibió los derechos ligados al marco espacial del Estado-nación y a una (...) concepción de la temporalidad como tiempo presente. Frente a ello, reivindicamos un nuevo paradigma de los derechos humanos que, a partir de la dimensión global de los problemas y de una concepción intergeneracional de la justicia, trascienda los límites territoriales del Estado e incorpore la dimensión del futuro en la protección de los bienes jurídicos. ABSTRACT: The globalisation era is, as Beck has pointed out, the age of global risk, characterized by the increasing level of risk in the management of technical means. In this context, the insufficiency of a model of understanding human rights linked to the first modernity becomes increasingly evident. Against this, we demand a new paradigm of human rights that, from the global dimension of problems and from an intergenerational conception of justice, transcend the territorial limits of the State and incorporate the dimension of future in the protection of legal assets. (shrink)

Dating manuscripts is a difficult task – particularly when these are not expressly datemarked, but even when they are. Factors such as the existence of successive copies that continue and repeat established models and production methods make dating a challenging task. The present work forms part of a much broader, comprehensive, investigation on the material composition of dated and bound manuscripts from the School of arabic Studies– CSIC of Granada. By means of a study protocol, errors in the dating of (...) manuscripts ms6, ms10, ms26 and ms29 are successfully detected and corrected, and alternative dating proposed. (shrink)

A finales del siglo XIX, la economía capitalista y las nuevas formas de consumo que trae implícitas tratando de seducir al individuo urbano con multitud de estímulos suponen un cambio en el modo en que este experimenta la ciudad. Esto conlleva la aparición de nuevas patologías, como la neurastenia, producto de un supuesto exceso de demanda del cerebro. Estos efectos fueron abordados en la época por Georg Simmel, quien se interesó por la reacción que sobre el individuo produce la urbe (...) capitalista ligada a la “intensificación de la vida nerviosa”. En el presente artículo se indaga en la lectura que Simmel plantea de los efectos que la ciudad moderna ejerce en el ciudadano. Me centro particularmente en la cuestión de la saturación de estímulos para tratar de entender no solo cómo creía que la ciudad afectaba al ciudadano en la época sino también el novedoso papel que otorga a la sensibilidad como intermediaria del vínculo entre individuo y ciudad. (shrink)

Os visigodos, que professavam o arianismodesde antes de seu estabelecimento na PenínsulaIbérica, converteram-se ao Catolicismo deNicéia em fins do século VI, por ocasião do mConcilio de Toledo, realizado em 589. Os vinculesentre a Igreja e o Estado, a partir deste momento,tomaram-se estreitos.A teoria política que sustentou ideologicamente oReino Visigodo, deste momento até a chegadados muçulmanos, encontra-se, fundamentalmente,nas obras de Isidoro de Sevilha e nas Atas dosConcílios de Toledo. Tais documentos serão objetode nosso estudo, que visa a reconstrução daslinhas mestras desta (...) teoria política. (shrink)

Previous evidence has shown that excessive valuing happiness may relate to lower psychological wellbeing across cultures. Considering the lack of data with Spanish population, we examined the relation between tightly holding happiness emotion goals and subjective wellbeing in a sample of Spanish women, and explored the mediation role exerted by psychological inflexibility components in the relation between valuing happiness and subjective wellbeing. A female adult sample filled out measures of excessive valuing happiness, psychological inflexibility, positive affect, negative affect, and life (...) satisfaction. Valuing happiness only showed positive total effects on negative affect and strong direct effects on both cognitive fusion and experiential avoidance. Analyses revealed the mediating roles exerted by psychological inflexibility components, with experiential avoidance leading to lower pleasure; and cognitive fusion leading to greater displeasure and lower life satisfaction. Psychological inflexibility components explained between 40 and 80% of the total effect of valuing happiness on our outcome variables. Our findings highlight the need for further research on the benefits of hedonic vs. values-based approaches to happiness. (shrink)

Recensión de N. Belloso Martín, El control democrático del poder judicial en España, Universidad de Burgos/ Moinho do Verbo, Curitiba, 1999.

Empathy is an emotional response that may facilitate prosocial behavior and inhibit aggression by increasing empathic concern for others. But the vicarious experience of other’s feelings may also turn into personal distress when the person has poor regulation skills and holds stigmatizing beliefs. In thinking about the processes that may trigger the experience of personal distress or empathic concern, research on the influence of psychological flexibility and inflexibility on stigma is showing promising results. Both processes are assessed with the Acceptance (...) and Action Questionnaire–Stigma. The current study sought to carry out a validity study of a Spanish version of the AAQ-S with a sample of adolescents aged 11–17 years. The study included an expanded test of its predictive validity with measures at three times to evaluate the role of psychological flexibility and inflexibility as risk or protective variables for the development of personal distress and/or empathic concern in the stigmatizer. Statistical analyses confirmed a two-correlated-factor solution, the adequate reliability of both factors, and their construct and predictive validity in the expected direction. The stigmatizer’s inflexible reaction to their stigmatizing thoughts predicted the occurrence of personal distress, whereas the stigmatizer’s flexible reaction to their stigmatizing thoughts predicted the occurrence of empathic concern for others. These findings confirm the importance of considering the role of regulatory skills in the experience of empathic concern or personal distress in the presence of stigmatizing thoughts, with possible implications for the promotion of prosocial behavior and the reduction of aggressive behavior among adolescents. (shrink)

Objective: Illness perceptions are important predictors of emotional and behavioral responses in many diseases. The current study aims to investigate the COVID-19-related IP throughout Europe. The specific goals are to understand the temporal development, identify predictors and examine the impacts of IP on perceived stress and preventive behaviors.Methods: This was a time-series-cross-section study of 7,032 participants from 16 European countries using multilevel modeling from April to June 2020. IP were measured with the Brief Illness Perception Questionnaire. Temporal patterns were observed (...) considering the date of participation and the date recoded to account the epidemiological evolution of each country. The outcomes considered were perceived stress and COVID-19 preventive behaviors.Results: There were significant trends, over time, for several IP, suggesting a small decrease in negativity in the perception of COVID-19 in the community. Age, gender, and education level related to some, but not all, IP. Considering the self-regulation model, perceptions consistently predicted general stress and were less consistently related to preventive behaviors. Country showed no effect in the predictive model, suggesting that national differences may have little relevance for IP, in this context.Conclusion: The present study provides a comprehensive picture of COVID-19 IP in Europe in an early stage of the pandemic. The results shed light on the process of IP formation with implications for health-related outcomes and their evolution. (shrink)

The coronavirus disease pandemic fundamentally disrupted humans’ social life and behavior. Public health measures may have inadvertently impacted how people care for each other. This study investigated prosocial behavior, its association well-being, and predictors of prosocial behavior during the first COVID-19 pandemic lockdown and sought to understand whether region-specific differences exist. Participants from eight regions clustering multiple countries around the world responded to a cross-sectional online-survey investigating the psychological consequences of the first upsurge of lockdowns in spring 2020. Prosocial behavior (...) was reported to occur frequently. Multiple regression analyses showed that prosocial behavior was associated with better well-being consistently across regions. With regard to predictors of prosocial behavior, high levels of perceived social support were most strongly associated with prosocial behavior, followed by high levels of perceived stress, positive affect and psychological flexibility. Sociodemographic and psychosocial predictors of prosocial behavior were similar across regions. (shrink)

En la historia intelectual de América Latina existe una laguna respecto a la producción de las mujeres en el género de ensayo. Son los ensayos de identidad criolla, de hechura masculina, los que construyen el canon respecto a las temáticas y a las maneras de ser abordado. Los ensayos de género que las escritoras han realizado se articulan como respuesta a esta visión dominante de los procesos sociales, políticos y culturales de los países latinoamericanos. Revelan un fuerte descontento con la (...) construcción de la identidad femenina, una preocupación por la construcción de una ciudadanía plena y representan una respuesta a las demandas sociales políticas y culturales de las mujeres y otros grupos marginales. Las intelectuales debatieron, discutieron y polemizaron con las propuestas que al respecto portaban los discursos dominantes y el ensayo de género se vuelve el “arma de combate”. Lo que aquí se presenta, tiene como objetivo la recuperación de este corpus de conocimiento en la historia literaria de Cuba, Puerto Rico y República Dominicana. Una labor de arqueología literaria de temas, obras y autoras a partir del siglo XX. Se brinda, a partir del libro Mujeres ensayistas del Caribe Hispano: Hilvanando el silencio (2007) deAnna Freire Ashbaugh, Lourdes Rojas y Raquel Romeu, una visión panorámica del conjunto de ensayistas de cada país. Otras investigadoras como Catharina Vallejo, Ivette Sóñora, Carmen Dolores Hernández y Consuelo Meza Márquez ampliaran ese corpus y señalan algunos rasgos temáticos de la obra ensayística de autoras como Luisa Campuzano, Mirta Yáñez, Nara Araujo, Marta Núñez Sarmiento y Zaida Capote Cruz de Cuba; Concha Meléndez, Rosario Ferré, Norma Valle Ferrer, Nara Negrón Marreño y Silvia Álvarez Curbelo de Puerto Rico; y, de República Dominicana, Camila Henríquez Ureña, Carmita Landestoy, Carmen Durán y Rosa Inés Curiel Pichardo. (shrink)