Transposable elements (TEs) are mobile genomic elements constituting a big fraction of eukaryotic genomes. They ignite an evolutionary arms race with host genomes, which in turn evolve strategies to restrict their activity. Despite being tightly repressed, TEs display precisely regulated expression patterns during specific stages of mammalian development, suggesting potential benefits for the host. Among TEs, the long interspersed nuclear element (LINE‐1 or L1) has been found to be active in neurons. This activity prompted extensive research into its possible role (...) in cognition. So far, no specific cause‐effect relationship between L1 retrotransposition and brain functions has been conclusively identified. Nevertheless, accumulating evidence suggests that interactions between L1 RNAs and RNA/DNA binding proteins encode specific messages that cells utilize to activate or repress entire transcriptional programs. We summarize recent findings highlighting the activity of L1 RNAs at the non‐coding level during early embryonic and brain development. We propose a hypothesis suggesting a mutualistic relationship between L1 mRNAs and the host cell. In this scenario, cells tolerate a certain rate of retrotransposition to leverage the regulatory effects of L1s as non‐coding RNAs on potentiating their mitotic potential. In turn, L1s benefit from the cell's proliferative state to increase their chance to mobilize. (shrink)

En este artículo se pretenden reconstruir las premisas fundamentales del pensamiento político de Dante, que plantea una nueva concepción de la relación entre Iglesia e Imperio. En particular, se señalan tres ideas fundamentales: la ciencia como perfección última del alma humana; la operación propia del género humano en la actuación de toda la potencia del intelecto posible; y, por último, la cuestión del fin natural y sobrenatural del hombre. A continuación, se analiza la presencia de la interpretación del aristotelismo de (...) la Facultad de Artes de la Universidad de París y del averroísmo presente en el planteamiento dantesco, en particular haciendo referencia a las diferentes interpretaciones de Gilson y Nardi. Finalmente, se proponen como clave de interpretación global del pensamiento político dantesco la cuestión del traspaso de las llaves de Jesús a Pedro y la relación entre naturaleza y gracia en disonancia con la interpretación de Tomás de Aquino. (shrink)

Kant repeatedly stresses that moral philosophy shall find completion in the shape of a system. The present chapter focuses on three main aspects that characterise his view of the need of a system of ethics, suggesting that Kant's view should be construed in contrast with the current assumptions on the role of a system in moral philosophy. First, I argue that, in Kant’s view, the system of ethics does not pursue the coherentist project of systematising moral beliefs. Systematicity in ethics (...) is, for him, about unfolding the obligations that are justified by the fundamental principle, according to a Pufendorfian paradigm widespread in the eighteenth century. Second, I show that, in contrast not only to current assumptions, but also to the Pufendorfian paradigm, Kant’s systematic treatment of ethics is neither a logically consistent arrangement of demands, nor a complete collection of ethical duties, but a system of ends that yields an open-ended system of duty types. Third, I suggest that in Kant’s view a systematic treatment of ethics is supposed to provide orientation to moral thinking through a broader perspective from which perplexing cases should be considered by emphasizing the holistic character of ethical demands and clarifying their connections. (shrink)

Gödel algebras form the locally finite variety of Heyting algebras satisfying the prelinearity axiom =. In 1969, Horn proved that a Heyting algebra is a Gödel algebra if and only if its set of prime filters partially ordered by reverse inclusion–i.e. its prime spectrum–is a forest. Our main result characterizes Gödel algebras that are free over some finite distributive lattice by an intrisic property of their spectral forest.

La importancia de la aportación de Agustín de Hipona acerca del estudio del fin de la historia y de la escatología es indiscutible. En este artículo se pretende reconstruir la evolución del pensamiento agustiniano desde una posición favorable a una plenitud intrahistórica de carácter eclesial —contenida particularmente en los «Sermones»— y el desarrollo de la «Ciudad de Dios» así como las razones de dicha evolución. El cambio de esta perspectiva se produce a través de una nueva exegesis del cap. XX (...) del Apocalipsis donde Agustín parece negar dicha posibilidad. (shrink)

Both in historical debates and in recent discussions, the Guise of the Good Thesis represents a genuine dogma of rationalism in moral philosophy. Many influential commentators have maintained that Kant belongs in that camp, even that he “explicitly endorses” the Thesis. Attributing the Thesis to Kant, however, faces scarce textual support and amounts to a dubious understanding of the relationship of Kant’s moral philosophy to previous rationalist views. I suggest that, in Kant’s view, the Thesis only applies to the determination (...) of the will through the moral law. The principle that prior rationalists regarded as descriptive acquires in Kant’s terms a normative status. (shrink)

In this paper, I address the question of how emotional qualities can be attributed to musical timbre, an acoustic feature that has proven challenging to explain using traditional accounts of musical emotions. I begin presenting the notion of musical expressiveness, as it has been conceived by cognitivists to account for the emotional quality of various musical elements like melody and rhythm. However, I also point out some limitations in these accounts, which hinder their ability to fully elucidate the emotional expressiveness (...) of timbre, especially when considering it as a result of non-cognitively mediated processes. Consequently, I explore the link between timbre and atmosphere by reviewing anecdotal sources that have characterized timbre in terms of atmosphere. The goal here is to determine if these characterizations should be seen as merely allusive and metaphoric expressions or if they genuinely reveal essential properties of timbre. To achieve this goal, I delve deeper into the notion of atmosphere, and I show that it shares several key traits with the notion of musical emotions as conceived in the cognitivist’s account. Both musical emotions and atmospheres are affectively charged externalities that are apprehended by the subject without cognitive mediation. Drawing from this insight, I conclude that the notion of atmosphere can serve as a valuable tool in explaining the emotional expressivity of timbre without invoking the resemblance-based mechanisms often found in cognitive accounts of expressiveness. (shrink)

This paper aims to show the significance of respect in revealing the normative structure of Kant’s ethics to the agent as a finite rational being. I argue that understanding the moral law as a fact of reason is insufficient for fully recognizing its absolute value and the normative consequences it entails. Indeed, the finiteness of the human agent requires the experience of the feeling of respect, which not only has a motivational role but also an epistemic one. I thus start (...) by clarifying the nature of feeling for Kant in a way that highlights its complex structure. Then, I show how respect – as a particular kind of feeling – gives the agent a deeper understanding of her relationship with the moral law, thereby allowing the unveiling of Kant’s normative theory. (shrink)

Schnieder (2020) argues, against Orilia (2009) and Koslicki (2013), that claims of existential grounding of the form “the fact that x exists is grounded in the fact that y is F” cannot be grounded in claims of existential dependence of the form “x existentially depends on y” and defends the view that the latter claims are grounded, via a definition of existential dependence, in the former. I will firstly argue that Schnieder’s main point against the claim that existential grounding is (...) grounded in existential dependence is not conclusive; I will then put forward a proposal concerning how claims of existential grounding can be grounded in claims of existential dependence. The proposal is a third way between those of Schnieder and Orilia/Koslicki which, although accepting the former’s definition of existential dependence in terms of grounding, makes room for the latter’s idea that existential dependence does the real job in structuring reality. (shrink)

In several places of his work, Kant distinguishes between two senses of self-consciousness: a pure one and an empirical one. The aim of this work is to analyze these two senses of consciousness and show that, for Kant, self-consciousness does not occur unrestrictedly: a relation with something other than consciousness is needed for it to become conscious of itself. I carry out these objectives throughout six sections. In the first one I lay out the Kantian principle of pure apperception. In (...) the second one, I present the limits of pure apperception through Kant’s critique of rational psychology. Then, in the third section, I set the basis to understand the relationship that Kant establishes between the I think and the I exist. In the fourth one I show that pure apperception, despite being pure, is not possible without the opportunity of perception. Next, in the fifth one, I introduce the notion of empirical apperception, establish its relationship with pure apperception, and elucidate its meaning. Finally, in the last section, I explain the way in which empirical self-consciousness is determined, in relation to the knowledge of objects of the external sense. (shrink)

Bochvar algebras consist of the quasivariety $\mathsf {BCA}$ playing the role of equivalent algebraic semantics for Bochvar (external) logic, a logical formalism introduced by Bochvar [4] in the realm of (weak) Kleene logics. In this paper, we provide an algebraic investigation of the structure of Bochvar algebras. In particular, we prove a representation theorem based on Płonka sums and investigate the lattice of subquasivarieties, showing that Bochvar (external) logic has only one proper extension (apart from classical logic), algebraized by the (...) subquasivariety $\mathsf {NBCA}$ of $\mathsf {BCA}$. Furthermore, we address the problem of (passive) structural completeness ((P)SC) for each of them, showing that $\mathsf {NBCA}$ is SC, while $\mathsf {BCA}$ is not even PSC. Finally, we prove that both $\mathsf {BCA}$ and $\mathsf {NBCA}$ enjoy the amalgamation property (AP). (shrink)

The purpose of this paper is to explore the epistemological tensions embedded within big data and data-driven technologies to advance a socio-political reconsideration of the public dimension in the assessment of their implementation.,This paper builds upon (and revisits) the European Union’s (EU) normative understanding of artificial intelligence (AI) and data-driven technologies, blending reflections rooted in philosophy of technology with issues of democratic participation in tech-related matters.,This paper proposes the conceptual design of sectorial and/or local-level e-participation platforms to ignite an ongoing (...) discussion – involving experts, private actors, as well as cognizant citizens – over the implementation of data-driven technologies, to avoid siloed, tech-solutionist decisions.,This paper inscribes the EU’s normative approach to AI and data-driven technologies, as well as critical work on the governance of these technologies, into a broader political dimension, suggesting a way to democratically and epistocratically opening up the decisional processes over the development and implementation of these technologies and turn such processes into a systemic civic involvement. (shrink)

English summary: How Niccolo Machiavelli is to be understood is still passionately argued today. The many facets of his political thought correspond to the diversity of perspectives among his interpreters. The authors of this interdisciplinary volume analyze Machiavelli's works in connection with transformations of thought on policy, rule and morality from the beginning of the early modern period through to the present. In addition to the interpretation of Machiavelli through the lens of his time, effects of his writings and thought (...) in contemporary discourse are focused upon. Topics not only include Machiavelli's relationship to the modern concept of the state and his experimental morality, but also his demonological style of reading and his presence amongst contemporary republicans and liberals, amongst thinkers such as Max Horkheimer and Michel Foucault, as well as in the empire debate. Additionally, the volume takes into account thus far little-explored aspects, such as Machiavelli's thinking style and methodology, as well as the literary-rhetorical dimension of his writings. German text. German description: Bis heute wird leidenschaftlich darueber gestritten, wie Niccolo Machiavelli verstanden werden muss. Dem Facettenreichtum seines politischen Denkens entspricht die Vielfalt der Perspektiven und Urteile seiner Interpreten. Die Autoren des interdisziplinar angelegten Bandes analysieren Machiavellis Werke im Zusammenhang mit den spiegelbildlichen Wandlungen des Denkens ueber Ordnung, Herrschaft und Moral zu Beginn der Neuzeit und in der Gegenwart. Ausser der Interpretation Machiavellis aus dem Horizont seiner Zeit stehen auch seine Wirkungen in zeitgenossischen Diskursen im Mittelpunkt. Themen sind nicht bloss Machiavellis Verhaltnis zum modernen Staatsbegriff und seine experimentelle Moral, sondern auch seine damonologische Leseweise und seine Prasenz bei zeitgenossischen Republikanern und Liberalisten, bei Denkern wie Max Horkheimer und Michel Foucault sowie in der Empire-Debatte. Zudem beruecksichtigt der Band bislang wenig erforschte Aspekte wie Machiavellis Denkstil und Methode sowie die literarisch-rhetorische Dimension seiner Schriften. (shrink)

We show that logic has more to offer to ontologists than standard first order and modal operators. We first describe some operators of linear logic which we believe are particularly suitable for ontological modeling, and suggest how to interpret them within an ontological framework. After showing how they can coexist with those of classical logic, we analyze three notions of artifact from the literature to conclude that these linear operators allow for reducing the ontological commitment needed for their formalization, and (...) even simplify their logical formulation. (shrink)

ABSTRACTThis introduction outlines the rationale of the symposium 'Vocabularies of Hope in Place of Vocabularies of Critique: Can Rorty Help Us to Redescribe Education?'. In particular, it argues that, despite some early statements of Richard Rorty, he may turn out to be a particularly timely thinker in reference to debates occurring in the field of educational theory and philosophy, especially by suggesting an engagement with the latter through vocabularies of hope. Moreover, after highlighting that a valuable dialogue may be established (...) between Rorty's stance and post-critical pedagogy, the introduction describes in broad strokes along which lines this conversation will unfold in the three papers and one response composing the symposium. (shrink)

The present work is a contribution towards understanding the cultural environment in which the concept of man and nature were conceived in India. The book has the virtue of presenting the Hindu philosophical systems in a style that is intelligible for even neophytes.

In the introductory essay, the editors will provide an overview of the debates on legal obligation the contributions of this volume directly engage with.

The increasing body of knowledge in fields like animal ethology, biology, and technology has not necessarily led to the improvement of animal welfare. On the contrary, it has enabled humans to exploit animals more functionally and on increasing scales of magnitude. Building on approaches that stem from posthumanism and critical animal studies, we argue that instead of aiming for more general production of scientific knowledge, what is needed to counter exploitation and oppression is an increased sensitivity towards animals that arises (...) from local, partial, and ‘situated knowledges’. In the first part of this paper we articulate an argument that proposes how such knowledges can arise from the practice of game design as a form of ‘doing multispecies philosophy’. The second part of this work expands this notion with an understanding of design as a practice of configuring and prefiguring situations in which we can enter in a relationship of response and attention with other ‘selves’, in other words, with entities that are alive. To explore the practical consequences of this framework, in the third part of this paper we discuss a game design project that involves some unexpected designerly negotiations with a colony of black ants. We conclude that our wider perspective concerning notions of knowledge, design, and selves could elicit changes in our empathy towards other beings and help us develop new ideas and knowledges that favour less anthropocentric futures. (shrink)

This article aims to approach the COVID-19 health crisis through the category of precarity in two senses. On the one hand, in the face of power, a state of exception has been configured as the new form of political handling of the new normality. On the other hand, the loss of public space has meant that community ties have been broken, fostering greater atomisation and loneliness. Both processes were already present in modernity and post-modernity and foster an increasing uprooting of (...) the individual through the loss of the symbolic axes of socialisation, as well as more intense social control. In short, the defining characteristic of the pandemic is the precarity of life. (shrink)

One way to conceptualize human life is to describe it as a process through which the biological body is progressively transformed into a psychological one through its mentalization and symbolization. This process occurs through the relational field, which begins with caregiver-infant proto-conversations and develops through adolescence into the ongoing complex interpersonal relational network we call society and culture. The essence and the problems of adolescents are intricately tied to the social and cultural contexts in which they experience life. Therefore, adolescence (...) cannot be understood if all the levels that it expresses are not taken into consideration. We identify three psycho-historical phases through which adolescence has changed in the past century: Oedipal; Narcissistic; and Post-narcissistic. In this last phase due to the psychological and historical failure of the narcissistic ideals, the ideal is mingling with the real in a wholly new way. This process has overturned Erikson's paradigm: identity, opposed and defined by a dichotomic otherness, must be transformed into a fluid integration of similarities and differences negotiated and developed through empirical interpersonal intersubjective experiences. This, in our perspective, is a possible key to understand the rapid change in the nature of consciousness, selfhood, and gendering in today's western world, together with some important psychopathological disorders which describe the new creative challenges of today's adolescents. (shrink)

When the first Conte government began converting the Five Star Movement and Lega’s manifestos into expenditure items for the 2019 budget law, it quickly became obvious that Italy’s macroeconomic po...

While 'space' and 'place' appear as key concepts in the study of culture, their complexity and mutability require ever-new frameworks when approaching them critically. Including chapters by authors from different fields, career stages, and geopolitical backgrounds, the contributors in this edited collection scrutinize the changing dynamics of space and place in relation to current political, social, and environmental urgencies across the globe. With chapters investigating both real and imaginary spaces and places, the diversified discussions included in this collection provide a (...) cohesive study for disclosing latent understandings of multiple phenomena characterizing the world in which we live. From the protests in Egyptian and Turkish squares, to the power-related narratives embedded in institutional buildings, from the development of the commercial arena in Victorian and Edwardian London, to the effects of current environmental concerns on the evaluation of urban and rural locations, the volume ultimately serves as a progressive connection of fields, minds, and outlooks through an innovative, pluralistic vision. This interdisciplinary focus not only emphasizes the centrality of spaces and places when disentangling the complexities comprising our past and present, but also suggests a more pluralistic approach for exploring fundamental concepts in future spaces and places studies. (shrink)

Die Epitome physica des Nikephoros Blemmydes (1197 – nach 1269) gilt als eines der meistverbreiteten Lehrbücher aristotelischer Naturphilosophie in der byzantinischen und nachbyzantinischen Welt. Dennoch blieb die handschriftliche Überlieferung bisher gänzlich unerforscht und der Text wurde nie in Form einer kritischen Edition zugänglich gemacht. Die Epitome physica stellt das zweite Buch der Εἰσαγωγικὴ ἐπιτομή (Einführendes Kompendium) dar, deren erstes Buch der Logik gewidmet ist. Als Grundlage dienten Blemmydes im Wesentlichen Aristoteles und seine Kommentatoren (sowie für den astronomischen Teil den Stoiker (...) Kleomedes), wobei er versuchte, eine Synthese der antiken Naturphilosophie mit der christlichen Weltanschauung zu erreichen. Von den über 120 erhaltenen Manuskripten der Epitome, die vom 13. bis ins 19 Jh. datieren, werden im vorliegenden Buch die Handschriften aus der Palaiologenzeit sowie die Mehrheit derjenigen aus der Renaissance manuskriptologisch und philologisch untersucht sowie ihre textgeschichtlichen Beziehungen rekonstruiert. Daneben kommen auch die Verbreitung und der kulturelle Stellenwert der Epitome physica in der byzantinischen Welt und in der europäischen Renaissance zur Darstellung. (shrink)

When does more data help and when does it not in the sciences? In the past decade, this question has become central because of the phenomenon of Big Data. While these discussions started as a result of somewhat naive ideas that have been closely analyzed and mostly rejected in the philosophy of data, the question about the epistemic difference that more or less data makes still matters, especially in light of the impressive performance of data science and machine learning tools, (...) which seem to improve their outcomes when they are trained on large volumes of data. In several areas of the sciences, having more data is also connected to methodological and epistemic benefits and more generally something that research should strive toward. More data is often equated to better science: this elicits crucial questions about the epistemic value of the quantity of data. In this chapter, we discuss this problem in light of current discussions in the life and health sciences and the philosophy of data. (shrink)