Ludwik Fleck is widely recognized as a precursor of Science and Technology Studies, but his case study on the development of the Wassermann reaction as a test for detecting syphilis has never been subjected to detailed empirical scrutiny. The fact that Fleck?s monograph is based on a limited set of documentary sources makes his work vulnerable to uncharitable critics. The problematic relation between thought collective and individual scientists in Fleck?s theoretical approach is another reason for a systematic re-examination (...) of his case study, using materials on the early period in the history of the Wassermann reaction (1906?1912). My re-examination highlights several problems in Fleck?s account: a misinterpretation of the switch from antigen detection to antibody detection; a neglect of the ?clinical connection?; an overemphasis on the importance of collective experience leading to implausible views on gross retrospective distortions supposedly inflicted by this experience upon the memories of individual participants; and, finally, a misjudgement of the significance of the acrimonious dispute over the intellectual ownership of the Wassermann reaction. What remains unscathed is Fleck?s picture of a zig-zag course of development from false initial assumptions via detours and cul-de-sacs to a clinically usable test in the end. (shrink)

This paper focuses on the role of regulation in the shaping new scientific facts. Fleck chose to study the origins of a diagnostic test for a disease seen as a major public health problem, that is, a ‘scientific fact’ that had a direct and immediate influence outside the closed universe of fundamental scientific research. In 1935, when Fleck wrote his book, Genesis and development of a scientific fact, he believed that the tumultuous early history of the Wassermann reaction had (...) come to an end, and that this reaction was successfully stabilized through the standardization of laboratory practices and thanks to the rise of a specific professional segment—the serologists. He could not have predicted that in the 15 years that followed the publication of his book, regulatory measures—barely metioned in his historical narrative—would play a key role in the destabilization of the original meaning of this reaction. The introduction of mass screening for syphilis—mainly via legislation that introduced obligatory premarital tests and promoted the testing of pregnant women—weakened in fine the link between Wassermann serology and infection by the etiological agent of syphilis, the bacterium Treponema pallidum. Fleck elected to study the Wassermann reaction because of its novelty, its complexity, and because it became the focus of a controversy regarding its origins. However, the Wassermann reaction was also one the first examples of a medical technology regulated by the state and incorporated into legal dispositions. It may therefore be seen as an exemplary case of the close intertwining of scientific investigations, their practical applications and regulatory practices. (shrink)

The sociological dimension of science is studied using the discovery of the Wasserman reaction and its accidental application as a test for syphilis as a basis, ...

Au cours des années 1910 et 1920, les effets conjugués des idées savantes sur la spécificité des anticorps, de la croyance profane à l’existence d’un sang syphilitique et de l’importance attribuée à la détection de la syphilis par les autorités sanitaires ont permis de transformer un test diagnostique peu efficace, la réaction de Wassermann, en «fait scientifique» incontestable. Ce fait scientifique établit l’équivalence« individu Wassermann positif= personne infectée par l’agent étiologique de la syphilis, la bactérie Treponema (...) pallidum ». Il a ainsi modifié les contours de l’entité nosologique «syphilis», les pratiques professionnelles, les représentations profanes de la syphilis et les politiques de santé. Tenu pour solide pendant une trentaine d’années, ce «fait scientifique» fut toutefois déstabilisé dans les années 1950 en raison du hiatus croissant entre les résultats accumulés grâce à la diffusion massive du test de Wassermann et les données épidémiologiques sur la prévalence de la syphilis, et de la comparaison entre les résultats de la réaction de Wassermann et ceux des nouveaux tests diagnostiques spécifiques du tréponème. Un pourcentage élevé de personnes «Wassermann positives» fut alors redéfini comme des « faux positifs biologiques », soit des individus souffrant de pathologies autres que la syphilis, mais cependant capables d’induire une réaction Wassermann positive. L’équivalence « personne Wassermann positive = individu infecté par Treponema pallidum » fut remplacée par l’équation« personne Wassermann positive = individu infecté par le tréponème ou faux positif biologique ». La nouvelle vision de la réaction de Wassermann modifia à son tour les pratiques des professionnels et les représentations que le grand public se fait de la maladie. L’histoire de la détection de la syphilis illustre les interactions complexes entre « faits scientifiques » et « faits sociaux» et l’interdépendance de leur évolution. (shrink)

Ludwik Fleck’s Genesis and Development of a Scientific Fact is an extended argument for the inclusion of social factors in the history and philosophy of science. Fleck uses the history of syphilis as his case study, which falls into two parts. In the first two chapters of his book, Fleck presents a history of the change of the concept of syphilis as a “carnal scourge with strong moralistic connotations” in the middle ages to the modern concept of (...) class='Hi'>syphilis as an infectious disease (1979, 77). In the second part of the book, he presents a detailed account of the development of a serum test for syphilis, the Wasserman reaction. Fleck also argues that perception is theory-laden, for example, in his comparative study of anatomical drawings, and for the importance of social pressures on the development of science, for example, in his discussion of the rivalry between nations to first develop a cure for syphilis, as demanded by politicians (1979, 133 ff. and 68). (shrink)

The rediscovery in the mid-1970s of Ludwik Fleck's initially neglected monograph, Entstehung und Entwicklung einer Wissenschaftlichen Tatsache, published in 1935 and translated in 1979 as Genesis and Development of a Scientific Fact, has resulted in extensive, still ongoing, secondary writings, mainly within the humanities. Fleck has been interpreted as furthering a relativistic conception of science. Nowadays, he is often viewed as an important contributor to contemporary sociology of science and a forerunner to Thomas Kuhn. Fleck's account of the Wassermann (...) reaction, which forms the basis of his epistemology, has been praised as developed by a scientist well acquainted with the field in question. Because of the scarcity of available material on Fleck, however, the question of his sources has remained an unsolved issue. In the present article, an alternative reading is suggested. By focusing on the scientific content of the monograph, mainly neglected in the modern interpretations of Fleck, and on the so far overlooked sources of his writings traced back to their German origin, a better understanding of Fleck's account of the Wassermann reaction can be given. The consequences of this alternative reading for the conception of Fleck's monograph and for the impetus of his mission are discussed. (shrink)

Although it is commonly said that the notions of sensitivity and specificity were first defined by Jacob Yerushalmy in 1947, the sensitivity and specificity of diagnostic tests have been assessed as far back as the early 1900s. These notions share a common origin with the development of serology. They were originally immunologic concepts, closely associated with the development of complement fixation reactions for syphilis. Here, the authors trace how immunologic sensitivity and specificity were transformed into diagnostic sensitivity and specificity. (...) By relocating the origins of these concepts to the early 20th century, they highlight how these origins were bound to then-commonplace assumptions about specific infectious disease entities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 10.2 (2005) 75-99 [Access article in PDF] Gynocentric Eco-Logics Trish Glazebrook All of our teachings come from things in nature, they come from the growing cycle, and everything is tied to the earth.1Ludwig Fleck describes in his Genesis and Development of a Scientific Fact how the concept of syphilis is "a result of the development and confluence of several lines of collective thought" (Fleck (...) 1979, 23). Diagnosis and treatment of the disease required that its symptomatology undergo transformation from "an undifferentiated and confused mass of information about chronic diseases characterized by skin symptoms" (1979, 1) into the concept of a single disease. Identifying the Spirochaeta pallida bacterium and diagnosing syphilis by means of the Wasserman reaction was only possible when an unclearly related collection of symptoms could be experienced as belonging together in a unified phenomenology.Likewise, I wish to provide a diagnosis and etiology, and suggest a curative possibility for a disease of modernity I will call phallic logic. Symptomatic of this sickness are wide-spread social alienation, global domination and oppression on the basis of gender, race, class and color, and epidemic eco-destruction. A body of critique exists in ecofeminist analyses that experiences these symptoms as a single disease: the phallic logic of modernity. "Logic" in this context does not mean the formal discipline [End Page 75] in which rules for the proper manipulation of abstract statements are laid down. Rather, "logic" in the sense used here is an epistemological term. It means the ways that understanding is structured. Phallic logic is the structure of understanding that permeates patriarchy. This logic takes its paradigm from scientific objectivity, but even voices from within the sciences themselves are arguing that contemporary human being must establish new ways of thinking about nature.I propose that such new eco-logics, that is, ways of thinking about nature, take their guidance from the physical environment. If nature informs knowledge claims, then knowledge itself is construed organically: it is finite and changing rather than fixed and eternal. Such logics can encompass the finitude of physical embodiment as an epistemological principle, and hence I identify them as gynocentric. They are not grounded in the disembodied Cartesian subject that feminists have shown so often and clearly to be typical of androcentric philosophizing. These logics draw instead on the physicality of environmental elements as well as of the thinker, and thus they allow nature's temporality to resonate within knowledge itself. They are not satisfied with a conceptual contrast between nature's on-going coming-to-be and passing-away and the alleged universality of knowledge. Rather, they take nature as a model for truth and acknowledge that nature infuses the things we say to be truth.There is an abundance of arguments for the differences between male and female writing and thinking.2 I speak in accord with these voices, but I frame my project differently. I will begin by presenting evidence of a call for alternative epistemologies from within the sciences, and then use ecofeminist analyses to argue that the scientists in question are moving away from a phallic logic toward gynocentric eco-logics. Next I will make clear three assumptions that underlie my account. The first two are Heideggerian. I accept his argument that the logic of modernity is scientific objectivity, and I use his account of truth and essence to argue that knowledge is situated rather than universal. Hence gynocentric eco-logics entail an essentialism that is historical rather than biological. I give up biology as the fixative for essence, but avoid a decline into what is entirely arbitrary and subjective by fixing essence in terms of cultural and historical location. Hence I am using a Heideggerian notion of situatedness, but applying it specifically to gender such that I can maintain that the category of "woman" is neither universal, nor shattered irreparably into [End Page 76] fragmented individualism. My Heideggerianism is further qualified in that I am not writing in the spirit of Heidegger's life-time project. I will take the force of his insights to be epistemological rather than metaphysical or ontological... (shrink)

This paper supplements an earlier one (Wassermann 1978b). Its views aim to reinforce those of Lewontin and other prominent evolutionists, but differ significantly from the opinions of some philosophers of science, notably Popper (1957) and Olding (1978). A basic distinction is made between 'laws' and 'theories of mechanisms'. The 'Theory of Evolution' is not characterized by laws, but is viewed here as a hypertheory which explains classifiable evolutionary phenomena in terms of subordinate classifiable theories of 'evolution-specific mechanisms' (ESMs), each (...) of which could apply to a host of species. Adaptations could result from ESMs that are rooted in molecular complementarities. The status of optimization theories that aim to predict best adapted states of organisms or populations is also discussed. (shrink)

MATERIALISTS claim that in principle mentality could be accounted for entirely by properties of matter. They must, of course, clarify, as far as possible, the precise scope of the concept "properties of matter." According to materialists there exists only one type of "substance" in the universe, namely matter. Sophisticated experimental and theoretical analyses have led contemporary physicists to interpret known material entities as being composed of two classes of elementary particles, namely quarks and leptons and constituents of interaction fields that (...) mediate interactions between some or all of the elementary particles and which comprise photons, gluons, intermediate bosons and gravitons. For instance, protons and neutrons are composed--by hypothesis--of quarks, while electrons are probably the most familiar leptons. Whether any analyzed and postulated elementary particles and constituents of interaction fields are "ultimate" components of matter can never be known. It remains always possible that more basic subcomponents of known components will be discovered. This has happened repeatedly throughout the history of physics. Hence, what physicists understand by the "physical properties" of the basic components of matter must always remain expressed in terms of usually intricate hypothetico-deductive theories which are tentative and fallible. Contemporary relativistic quantum mechanics of elementary particles and of interaction fields provide typical examples of such hypothetico-deductive theories relating to present known basic components of matter. (shrink)

SummaryExtremism in the environment‐versus innateness controversy in the behavioural sciences and in human sociobiology is being examined. Genetic effects can be severely modified or overruled by environmental factors, but may, nevertheless, be important. Dawkins' view that we are survival machines programmed to subserve selfish genes seems untenable and is a root of racialism. It is also argued that morality is compatible with mixed genetic and environmental control of brains via existing biological machinery.

The AGM paradigm for belief revision provides a very elegant and powerful framework for reasoning about idealized agents. The paradigm assumes that the modeled agent is a perfect reasoner with infinite memory. In this paper we propose a framework to reason about non-ideal agents that generalizes the AGM paradigm. We first introduce a structure to represent an agent's belief states that distinguishes different status of beliefs according to whether or not they are explicitly represented, whether they are currently active and (...) whether they are fully accepted or provisional. Then we define a set of basic operations that change the status of beliefs and show how these operations can be used to model agents with different capacities. We also show how different operations of belief change described in the literature can be seen as special cases of our theory. (shrink)

The standard theory of belief revision was developed to describe how a rational agent should change his beliefs in the presence of new information. Many interesting tools were created, but the concept of rationality was usually assumed to be related to classical logics. In this paper, we explore the fact that the logical tools used can be extended to other sorts of logics, as proved in (Hansson and Wassermann, 2002), to describe models that are closer to the rationality of (...) a real agent. (shrink)

The AGM theory of belief revision provides a formal framework to represent the dynamics of epistemic states. In this framework, the beliefs of the agent are usually represented as logical formulas while the change operations are constrained by rationality postulates. In the original proposal, the logic underlying the reasoning was supposed to be supraclassical, among other properties. In this paper, we present some of the existing work in adapting the AGM theory for non-classical logics and discuss their interconnections and what (...) is still missing for each approach. (shrink)

This paper is intended as a contribution to a recent vigorous debate inThe Times, between the distinguished journalist Bernard Levin, the eminent Oxford economist Wilfred Beckerman and the Archbishop of York, John Habgood, among others. The debate concerns morality, ‘free will’ and determinism. As a former German Jew, who lost close relatives at Auschwitz and who suffered personally severely in my youth under daily virulent Nazi persecution, I obviously cannot remain strictly detached and neutral. Yet, I shall attempt to retain (...) as much neutrality as possible, since I think that the main rivals in this debate have all some very relevant, interesting and valid things to say. Let me also state other, probably very relevant, biases. I am an ardent Zionist. In addition, I am a diehard mechanistic materialist as regards basic philosophy, although I am tolerant of other people's religious feelings, because I realize that my materialism is as metaphysical as their religious views. With this as background let me return to the technical issues. Obviously, in a philosophical journal one can write at a level above that ofThe Times, where there is, perhaps, insufficient room to debate philosophical, biological, physical and other niceties in some depth. (shrink)

In the area known as model-based diagnosis, a system is described by-means of a set of formulas together with assumptions that all the components are functioning correctly. When we observe a behavior of the system which is inconsistent with the system description, we must relax some of the assumptions. In previous work, we have presented operations of belief change which only affect the relevant part of a belief base. In this paper, we propose the application of the same strategy to (...) the problem of model-based diagnosis. We Erst isolate the subset of the system description which is relevant for a given observation. By doing this, we reduce the size of the problem and then solve the diagnosis problem for the relevant subset. (shrink)

This work looks at how matter and mind inter-relate. It looks at the subject in terms of the philosophy of science, the philosophy of mind, thermodynamics, mechanistic materialism and psychological SETs. Rationality, relativism and Popper's views are taken into account.

This text deals with a number of topics in philosophy, philosophy of science and philosophy of mind. It includes essays on the laws of nature, biological aspects of the philosophy of mind, and the social aspects of rationality.

New York, USA. ERi2;mail: schopra@cse.unsw. edu. au ROHIT PARIKH, Brooklyn College 0f CUNY and CUNY Graduate Center, New York, USA. E-mail: ripbc@cunyum. cuny. edu..

Calling for explanations to examples of evolutionary adaptation, this work presents the Darwinian TIMA theory. The adaptations are followed by a philosophical and scientific critique of creationism which shows that the theory of evolution is a hypothetico-deductive scientific theory.

This book offers concrete and specific suggestions for improving teacher education programs.

This is a book for teachers and parents as well who seek to develop such self-directed, “can-do” children.

This book provides a collection of ten cases for use in the middle grades that focus on many of the critical social issues we face today.

Introduces the skill of comparing and challenges the reader to practice and master it as a part of thinking critically and creatively.

This book for teachers and parents makes an important case for the need for developing moral behavior in young children. It offers effective tools for teaching children to weigh decisions in the face of potential consequences, examine rationales for their choices, study the effects of their choices on others.

An agent can usually hold a very large number of beliefs. However, only a small part of these beliefs is used at a time. Efficient operations for belief change should affect the beliefs of the agent locally, that is, the changes should be performed only in the relevant part of the belief state. In this paper we define a local consequence operator that only considers the relevant part of a belief base. This operator is used to define local versions of (...) the operations for belief change. Representation theorems are given for the local operators. (shrink)

Reasoning and change over inconsistent knowledge bases is of utmost relevance in areas like medicine and law. Argumentation may bring the possibility to cope with both problems. Firstly, by constructing an argumentation framework from the inconsistent KB, we can decide whether to accept or reject a certain claim through the interplay among arguments and counterarguments. Secondly, by handling dynamics of arguments of the AF, we might deal with the dynamics of knowledge of the underlying inconsistent KB. Dynamics of arguments has (...) recently attracted attention and although some approaches have been proposed, a full axiomatization within the theory of belief revision was still missing. A revision arises when we want the argumentation semantics to accept an argument. Argument Theory Change encloses the revision operators that modify the AF by analyzing dialectical trees—arguments as nodes and attacks as edges—as the adopted argumentation semantics. In this article, we present a simple approach to ATC based on propositional KBs. This allows to manage change of inconsistent KBs by relying upon classical belief revision, although contrary to it, consistency restoration of the KB is avoided. Subsequently, a set of rationality postulates adapted to argumentation is given, and finally, the proposed model of change is related to the postulates through the corresponding representation theorem. Though we focus on propositional logic, the results can be easily extended to more expressive formalisms such as first-order logic and description logics, to handle evolution of ontologies. (shrink)