The direction and specificity of endolysosomal membrane trafficking is tightly regulated by various cytosolic and membrane‐bound factors, including soluble NSF attachment protein receptors (SNAREs), Rab GTPases, and phosphoinositides. Another trafficking regulatory factor is juxta‐organellar Ca2+, which is hypothesized to be released from the lumen of endolysosomes and to be present at higher concentrations near fusion/fission sites. The recent identification and characterization of several Ca2+ channel proteins from endolysosomal membranes has provided a unique opportunity to examine the roles of Ca2+ and (...) Ca2+ channels in the membrane trafficking of endolysosomes. SNAREs, Rab GTPases, and phosphoinositides have been reported to regulate plasma membrane ion channels, thereby suggesting that these trafficking regulators may also modulate endolysosomal dynamics by controlling Ca2+ flux across endolysosomal membranes. In this paper, we discuss the roles of phosphoinositides, Ca2+, and potential interactions between endolysosomal Ca2+ channels and phosphoinositides in endolysosomal dynamics. (shrink)

When we say “I know why he was late”, we know not only the fact that he was late, but also an explanation of this fact. We propose a logical framework of “knowing why” inspired by the existing formal studies on why-questions, scientific explanation, and justification logic. We introduce the Kyi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${{\mathcal {K}}{}\textit{y}}_i$$\end{document} operator into the language of epistemic logic to express “agent i knows why φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} (...) \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document}” and propose a Kripke-style semantics of such expressions in terms of knowing an explanation of φ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varphi $$\end{document}. We obtain two sound and complete axiomatizations w.r.t. two different model classes depending on different assumptions about introspection. Finally we connect our logic with justification logic technically by providing an alternative semantics and an in-depth comparison on various design choices. (shrink)

There is no notion of postmortem Heaven and Hell in both ancient Israeli and Confucian traditions, and the two traditions also share quite a number of similarities about the idea of immortal life after death. Therefore, a comparison of the commonness in this field, e.g. the Jewish Levirate Marriage custom and the Confucian custom of adopting one’s son as heir; the idea of name surviving death in Biblical Judaism and that of glorifying one’s parents by making one’s name famous in (...) future ages in Confucianism, can help us reveal the common pursuit in the two traditions: the postmortem fulfillment of an individual is realized in the form of the continuation of one’s family/ tribe/ nation of which they were, and forever remain, a generational link. In addition, this can help clarify a long faulted Confucian dogma of “Having no male heir being the gravest of the three cardinal offences against filial piety”. (shrink)

Historical progress is a core belief of the Enlightenment and modernity, also a spiritual catalyst of human emancipation in the past centuries. However, due to the naive understanding of scholars and its misuse by political power, the idea of progress has fallen from a realistic political belief in the pursuit of liberty and democracy to a metaphysical faith and a one-sided ideology. Instead of abandoning the concept itself, this paper will provide a new version for progress. In this version, supported (...) theoretically with ideas from a Marxian critique of the paradox of progress in capitalist society and a Habermasian reconstruction of social evolution and progress, progress shall not be understood as an intrinsic trend of history itself, but a “historical-practical project” of humanity. The intent of rewriting progress is to transcend the dilemma between progressivism and catastrophism while at the same time preserving its positive meaning. (shrink)

In ancient China, astronomers attempted to correct mean geocentric longitude of the inner planets using planetary “Expansion–Contraction Difference” (yingsuo cha 盈縮差) to obtain the true geocentric longitude. They used the “Limit Degree” (xiandu 限度) as the independent variable for the “Expansion–Contraction Difference”. Although this idea was relatively ideal and operationally simple, the algorithm of the “Expansion–Contraction Difference” designed by ancient Chinese astronomers had significant flaws in terms of its actual computational effectiveness for calculating the position of the inner planets. The (...) reason for this flaw is that, based on its intended purpose, the “Expansion–Contraction Difference” should be a three-variable function, including the planetary equation of center, the solar equation of center and the phase angle of the planet, and each variable has different independent variables. However, ancient Chinese astronomers attempted to simplify this complex three-variable function into a single-variable function, and such simplification was unsuccessful. Further research indicates that the starting point of the expansion phase in the “Table of Expansion–Contraction Difference” (Yingsuo Li 盈縮曆) for the inner planets in ancient Chinese astronomical systems did not accurately depict the position of the planetary perihelion. Adjusting the starting point based on the longitude can improve the accuracy to some extent. Although the special coefficients of “double it for Venus, triple it for Mercury” can enhance the accuracy of calculations on the position of the inner planets, the result is not as ideal as expected. This study highlights that within the framework of ancient Chinese planetary theory, the algorithm of the “Expansion–Contraction Difference” for the inner planets possessed inherent and irreparable flaws, resulting in significant errors in the calculation of the apparent position of the inner planets. (shrink)

I propose to sketch my views on several aspects of the philosophy of mathematics that I take to be especially relevant to philosophy as a whole. The relevance of my discussion would, I think, become more evident, if the reader keeps in mind the function of (the philosophy of) mathematics in philosophy in providing us with more transparent aspects of general issues. I shall consider: (1) three familiar examples; (2) logic and our conceptual frame; (3) communal agreement and objective certainty; (...) (4) the transcommunal universality of mathematics; (5) the big jump to the potential infinite; (6) the reconciliation of local creation with the hypothesis of discovery; (7) Platonism as realism plus conceptualism; (8) foundational studies and mathematical practice; and (9) the decomposition of philosophical disagreements. The views of Gödel and Wittgenstein are emphasized in order to add specificity to the discussions. (shrink)

This study investigated the psychometric properties of an adapted Chinese version of Motivated Strategies for Learning Questionnaire using exploratory factor analysis and confirmatory factor...

The Slow Movement brought with itself a focus on the speed of our living, and a desire to slow down our daily activities, including movement activities. Also, in the time of the current pandemic, m...

This paper introduces Song Siyeol, known as Master Song (Songja 宋子), who had a great influence on Korean philosophy and politics in late Joseon (18-19th century). Among his Great Compendium, there are substantial body of writings and comments related to women. As his views directly and indirectly contributed to shaping orthodox Korean Neo- Confucian views regarding women, his writings are an invaluable resource for understanding women and gender in the late Joseon period. This paper presents his views on women, focusing (...) on issues related to rituals. By highlighting and analyzing the issues discussed regarding the role of women in four traditional family rituals, I delineate ways in which Song Siyeol positioned women in his ritualist metaphysics and use this analysis to examine his philosophical approach, which reflects his views on, and understanding of, women, gender, and associated philosophical concepts, while making meaningful and practical discoveries that can be embraced and implemented by women and people today. (shrink)

In order to solve the problems of poor physical fitness of college students and low efficiency of college sport venues' management, an intelligent sports management system based on deep learning technology is designed by using information technology and human-computer interaction under artificial intelligence. Based on the Browser/Server structure, the intelligent sports management system is constructed. The basic framework of Spring Cloud is used to integrate the framework and components of each part, and a distributed microservice system is built. The artificial (...) intelligence recommendation algorithm is used to analyze the user's age, body mass index, and physical health status, and recommend sports programs suitable for students, thus realizing the intelligent sports program recommendation function. At the same time, the recommendation algorithm is used to complete the course recommendation according to the students' preferences, teaching distance, opening time, course evaluation, and other indexes, and the course registration system is constructed; after the analysis of the entity and the relationship between the entities of the intelligent sports system, the database relational model of the system is designed with the entity relationship diagram. The results of the functional test show that the system can run well. In conclusion, the sports training environment instructional system based on artificial intelligence and deep learning technology can meet the teaching needs of colleges, improve the sports' quality for college students, and promote psychological education. (shrink)

Familiarity and green image influencing travelers’ green hotel patronage have often been overlooked in previous research. The aim of this study was to examine the relationship of the two dimensions of familiarity and the two dimensions of image with the overall image, satisfaction, and loyalty. The theoretical research model used in this study was based on the stimulus–organism–response framework. The research design for this study employed a quantitative approach using a purposive sampling method involving 488 student responses. The tests of (...) the proposed hypotheses were conducted using SPSS and AMOS. The results of the study showed that experiential familiarity and informational familiarity positively influenced cognitive image and affective image, respectively, while cognitive image had a positive influence on the affective image. In addition, cognitive and affective images have a positive influence on the overall image, and the overall image is shown to have a positive impact on satisfaction and loyalty. Finally, satisfaction was found to have a positive influence on loyalty, while satisfaction plays a partial meditation role in the relationship between overall image and loyalty. (shrink)

To improve the intelligence of urban and rural buses, it is necessary to realize the accurate prediction of bus arrival time. This paper first introduced urban and rural buses. Then, the arrival time prediction was divided into two parts: road travel time and stop time, and they were predicted by the support vector regression method and k-nearest neighbor (KNN) method. A section of a bus route in Pingdingshan city of Henan province was taken as an example for analysis. The results (...) showed that the method designed in this study had better accuracy, and the result was closer to the actual value, with a maximum error of 84 s, a minimum error of 10 s, an average error of 42.5 s, and an average relative error of 5.74%, which could meet the needs of passengers. The results verify the reliability of the designed method in predicting the arrival time of urban and rural buses, which can be popularized and applied in practice. (shrink)

The formation and research of Constructivism theory is another understanding in developing educational psychology. Many problems exist in English vocabulary teaching and learning, which are too common to be noticed, negatively and implicitly impacting Students’ English Vocabulary Memorization. In order to solve these problems, this work studies college Students’ EVM from the perspective of Constructivism. Firstly, the literature review and observation method understand the Students’ EVM performance and teaching behavior. Secondly, it analyzes the current situation, problems, and reasons for Students’ (...) poor EVM abilities. Finally, combined with relevant theories, a college Students’ EVM-oriented teaching model is proposed, whose effectiveness is verified by teaching experiments. The experiment recruits100 freshmen, including 60 boys and 40 girls, and lasts half a semester. The average score of the final exam in the experimental group is more than 90, which is better than that in the control group. Then, the SPSS21.0 is used in the independent-samples t-test, finding no significant difference. Thus, the experimental group’s comprehensive English Proficiency Level has not been negatively affected. The proposed teaching model can improve Students’ EVM efficiency and consolidate their memory. The proposal has important guiding significance for stimulating Students’ interest in English vocabulary learning and the quality of vocabulary teaching. (shrink)

This essay is a study of Non-actualism, the thesis that there are objects which do not exist. There are several difficulties surrounding this thesis. First, there is the question about how to make sense of this very thesis. Second, there is the problem about what evidences there are for such a thesis. Third, there is a serious doubt about whether such thesis can be held consistently. ;The first question is usually claimed to be answered by Non-actualists by distinguishing two kinds (...) of quantifiers: existential quantifiers and a "broader" sort of quantifiers. My suggestion in this essay is, however, that there is a more ordinary use of the phrase "there is" which makes the Non-actualist thesis perfectly intelligible. After clarifying what I mean by "Non-actualism", especially after clarifying what the phrase "there is" is used to mean, I go on to check what evidences there are for such a doctrine. In the literature, three different sorts of evidences are usually cited by Non-actualists to defend their positions: fictional talk, modal talk, and our experiences about things not existing. I reject the first two but endorse the last one mainly on the ground that non-actual talk is subject to different interpretations and is only remotely related to ontological issues. However, there still is a threat of inconsistency for those Non-actualists who want to defend their positions from the empirical or phenomenological aspect. In this essay, I distinguish three kinds of paradoxes that a Non-actualist has to solve, and show their independence. I call them, separately, the Sosein Paradox, the Sein Paradox and the Cardinality Paradox. Further, I show that most Non-actualist theories which are designed mainly to solve these paradoxes do not really accomplish their task. But, to our surprise, there is a Meinongian thought which solves these paradoxes quite naturally, even though it did not aim at such a solution when it was developed. And I attribute this theory to Butchvarov. (shrink)

There are many Chinese versions of The Communist Manifesto and all of them had problems with the translation of foreign concepts and words, which triggered debates for years. One of the most interesting questions in the debates on the translation of the Manifesto is how to translate Assoziation / “association” and how Marx understood this concept.

This article is a review of the rise and development of women’s studies and the sociology of women/gender, two interrelated academic fields in China. Informed by the sociology of knowledge, the authors analyze how historical and sociopolitical factors such as the legacy of Marxism, state/party control, economic reform, political upheavals, local conditions, and global influences have greatly shaped what and how women’s and gender issues are studied and the resultant characteristics and knowledge production of the two fields in China. Specifically, (...) the authors examine the dynamic process of knowledge development in sociology of women/gender in terms of its academic positioning, standpoint, content, research methodology, curriculum transformation, and teaching in China. Finally, the authors demonstrate how the characteristics and issues shared by the two fields have evolved in a dynamic interplay between Chinese Marxism and feminism. (shrink)

In China, online sales continue to grow against the generally adverse effects of the COVID-19 pandemic on economic development. Although advertisers favor online targeted advertising for its precision, consumers may find it intrusive and avoid it. This study constructed a conceptual model based on Stimulus-Organism-Response theory, Approach-Avoidance Theory, and Brand Avoidance Theory to investigate the influence mechanism of consumers’ perceived risk on the avoidance behavior of online targeted advertising via an online survey. Collected 436 validated data was analyzed through structural (...) equation method in AMOS statistical software. Results showed that the positively influenced advertising avoidance, and negative emotions mediated the relationship between perceived performance risk, time-loss risk, freedom risk, and advertising avoidance, but perceived privacy risk did not influence advertising avoidance through negative emotions. Perceived COVID-19 risk moderates the effect of negative emotions on advertising avoidance. The findings provide important insights for helping governments, advertisers and online platforms into which risk perceptions influence advertising avoidance, and suggests ways to mitigate consumers risk perceptions for the mutual benefit of brands and users. (shrink)

This work is devoted to studying the stochastic stabilization of a class of neutral-type complex-valued neural networks with partly unknown Markov jump. Firstly, in order to reduce the conservation of our stability conditions, two integral inequalities are generalized to the complex-valued domain. Secondly, a state-feedback controller is designed to investigate the stability of the neutral-type CVNNs with H ∞ performance, making the stability problem a further extension, and then, the stabilization of the CVNNs with H ∞ performance is investigated through (...) a sampling-based event-triggered control for the first time that the transmission event is not triggered except when it violates the event-triggered condition. Finally, two examples are given to illustrate the validity and correctness of our obtained theorems. (shrink)

The recent coronavirus disease 2019 pandemic pushed almost all institutions to adopt online and virtual education. The uncertainty of this situation produced various questions that perplexed educationists regarding what implications the pandemic would have on educational institutions, especially regarding how the switch to online education would impact the behavior and performance of students. The vast importance of this matter attracted the attention of researchers and served as the motivation for this research, which aims to resolve this confusion by studying the (...) use of mobile learning among students for educational purposes during the COVID-19 period. This study also examines how this situation has affected student learning behavior and performance in the higher education setting. This research is based on collaborative learning theory, sociocultural learning theory, and ML theory. This quantitative research employed the convenient sampling technique to collect data through structured questionnaires distributed to 396 students of higher education institutions who carry a mobile device. This study used descriptive and inferential statistics to make the data more meaningful. Structural equation modeling with AMOS software was used for hypothesis testing. The results showed that ML was a significant and positive predictor of SP and LB. Moreover, student LB partially mediated the relationship between ML and SP. The findings suggest that the academic performance of students can be enhanced by building a ML environment that aligns with the LB of students. Nevertheless, content suitable for ML must be developed, and future research should be conducted on this topic. (shrink)

Disagreeing with most authors on vagueness, the author proposes a solution that he calls ‘three-valued semantic pluralism’ to the age-old sorites paradox. In essence, it is a three-valued semantics for a first-order vague language with identity with the additional suggestion that a vague language has more than one correct interpretation. Unlike the traditional three-valued approach to a vague language, three-valued semantic pluralism can accommodate the phenomenon of higher-order vagueness and the phenomenon of penumbral connection when equipped with ‘suitable conditionals’. The (...) author also shows that three-valued semantic pluralism is a natural consequence of a restricted form of the Tolerance principle ) and a few related ideas, and argues that ) is well-motivated by considerations about how we learn, teach, and use vague predicates. (shrink)

This commentary provides a critique of Žižek’s 2021 article on the catastrophe of the U.S. military withdrawal from Afghanistan with a focus on Zizek’s nostalgic moment of the fully engaged subject. The commentary deploys the actual and possible scenarios of the form of subjectivity in association with the cynical subject and the sadistic superego; and suggests the possibility of an alternative ethical subjectivity.

Background: It has been reported that type 2 diabetes is associated with olfactory identification impairments and cognitive decline. However, the relationship between OI impairments and cognitive decline is largely unknown in T2DM patients.Methods: Sixty-eight T2DM patients and 68 healthy controls underwent 3D-T1 MRI scans, olfactory and cognitive assessments. The cortical thickness of olfaction-related brain regions, olfactory and cognitive scores were compared between groups. Correlation analyses were carried out among cognition, olfaction, and cortical thickness of olfaction-related brain regions.Results: First, the cognitive (...) and olfactory test scores of T2DM patients were lower than healthy subjects. Second, higher olfactory scores were associated with increased cortical thickness in the left parahippocampal gyrus and bilateral insula in T2DM. Third, higher olfactory scores were associated with higher cognitive performance in T2DM. Fourth, some cognitive performances were related to cortical thickness in the left parahippocampal gyrus and left insula in T2DM.Conclusion: These findings indicated that olfactory dysfunction may be useful for future applications that attempt to predict cognitive decline or develop tailored therapies in T2DM patients. (shrink)