Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of viral NS3/4A (...) protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)

Multi-stakeholder initiatives have been praised as vehicles for tackling complex sustainability issues, but their success relies on the reconciliation of stakeholders’ divergent perspectives. We yet lack a thorough understanding of the micro-level mechanisms by which stakeholders can deal with these differences. To develop such understanding, we examine what frames—i.e., mental schemata for making sense of the world—members of MSIs use during their discussions on sustainability questions and how these frames are deliberated through social interactions. Whilst prior framing research has focussed (...) on between-frame conflicts, we offer a different perspective by examining how and under what conditions actors use shared frames to tackle ‘within-frame conflicts’ on views that stand in the way of joint decisions. Observations of a deliberative environmental valuation workshop and interviews in an MSI on the protection of peatlands—ecosystems that contribute to carbon retention on a global scale—demonstrated how the application and deliberation of shared frames during micro-level interactions resulted in increased salience, elaboration, and adjustment of shared frames. We interpret our findings to identify characteristics of deliberation mechanisms in the case of within-frame conflicts where shared frames dominate the discussions, and to delineate conditions for such dominance. Our findings contribute to an understanding of collaborations in MSIs and other organisational settings by demonstrating the utility of shared frames for dealing with conflicting views and suggesting how shared frames can be activated, fostered and strengthened. (shrink)

T. J. Mawson's highly readable and engaging new introduction to the philosophy of religion offers full coverage of the key issues, from ideas about God's nature and character to arguments for and against His existence. Mawson's conversational style, lively wit, and enlightening examples make Belief in God as pleasurable as it is instructive and thought-provoking. It makes an ideal text for beginning undergraduate courses and for anyone thinking about these most important of questions.

P.F. Strawson argued that ‘mature sensible experience (in general) presents itself as … an immediate consciousness of the existence of things outside us’ (1979: 97). He began his defence of this very natural idea by asking how someone might typically give a description of their current visual experience, and offered this example of such a description: ‘I see the red light of the setting sun filtering through the black and thickly clustered branches of the elms; I see the dappled deer (...) grazing in groups on the vivid green grass…’ (1979: 97). In other words, in describing experience, we tend to describe the objects of experience – the things which we experience – and the ways they are when we are experiencing them. Some go further. According to Heidegger. (shrink)

This article asks about the conditions of a sociological operationalization of the capability approach developed by Amartya Sen and Martha Nussbaum. Raising the question of freedom and social opportunities, the capability approach has so far mainly been discussed by economists and philosophers. In order to adopt this approach for a sociological and pragmatist perspective, it engages with methodological and theoretical issues. Whereas capabilities have until now mainly been studied within quantitative frameworks, the author opts for a qualitative method of inquiry (...) that draws on a pragmatist and configurational approach. Such a shift towards qualitative inquiry is a key condition for a better sociological understanding of notions like freedom and opportunities that stand at the core of the capability approach. (shrink)

argues that when reproduction is sexual, natural selection can explain why individual organisms possess the traits they do. In stating his argument Matthen makes use of a conception of individual organisms as receptacles for collections of genes—a conception that cannot do the work Matthen requires of it. Either these receptacles are abstract objects, such as bare possibilities for organisms, or they are concrete. The first reading is too weak, since it allows selection to explain individual traits in both sexual and (...) asexual contexts. The only concrete entities we might think of as receptacles for collections of genes are male or female gametes. It is true that in the sexual context selection explains why an individual gamete combines with a second gamete of one type rather than another; however, this is not to say that selection explains why an individual organism has the traits it does. (shrink)

Body ecology by cosmosis refers to the experience of immersion, or the incorporation of the elements of nature through a body practice, leisure or sport. In this article, we propose comprehensive u...

What does evaluation mean? This article examines the evaluative process as a practical judgment that links a situation to a set of values in order to decide upon a course of action. It starts by discussing A. Sen’s “relational” and “comparative” account of evaluation, built in critical dialogue with J. Rawls’ deductive theory. Comparison, incompleteness, reality, and deliberation are the key principles of Sen’s approach, which, in some respects, echoes that of J. Dewey. The second part shows the relevance of (...) completing Sen’s approach with Dewey’s pragmatism, since Dewey’s emphasis on practical judgment is a useful counterbalance to Sen’s focus on evaluation as a cognitive process. Dewey introduces a shift from values to valuation and draws a distinction between prizing and appraising, which makes the logic of inquiry and the search for consistency between means and ends in a given situation the fulcrum of evaluation. The third part of this paper addresses the relationship between values and norms in evaluative processes. Neither Sen nor Dewey deals with this question in a systematic way, although norms, which are both similar and different from values, contribute to frame evaluations in different ways: as horizons, resources, or constrains. Bringing norms into the picture means completing the pragmatist account with an institutionalist perspective, as we suggest through the example of the evaluation of work. (shrink)

Michael and has argued that species have intrinsic essences. This paper rebuts Devitt’s arguments, but in so doing it shores up the anti-essentialist consensus in two ways that have more general interest. First, species membership can be explanatory even when species have no essences; that is, Tamsin’s membership of the tiger species can explain her stripyness, without this committing us to any further claim about essential properties of tigers. Second, even the views of species that appear most congenial to essentialism—namely (...) phenetic and genotypic cluster accounts—do not entail strong forms of intrinsic essentialism. (shrink)

The central and defining characteristic of thoughts is that they have objects. The object of a thought is what the thought concerns, or what it is about. Since there cannot be thoughts which are not about anything, or which do not concern anything, there cannot be thoughts without objects. Mental states or events or processes which have objects in this sense are traditionally called ‘intentional,’ and ‘intentionality’ is for this reason the general term for this defining characteristic of thought. Under (...) the heading of ‘thought’ we can include many different kinds of mental apprehension of an object—including relatively temporary episodes of contemplating or scrutinising, as well as persisting states like beliefs and hopes which are not similarly episodic in character. These are all ways of thinking about an object. But even construing ‘thought’ in this broad way, it is clear that not all mental states and events are thoughts: sensations, emotions and perceptual experiences are not thoughts, but they are also paradigmatically mental. Do these mental states and events have objects too? Or are there mental states and events which have no objects? 1 The view that all mental phenomena have objects is sometimes called ‘Brentano’s thesis’ or the thesis that intentionality is the ‘mark’ of the mental.1 Sometimes the name ‘Brentano’s thesis’ is given to certain other views too: for example, to the view that only mental phenomena are intentional, or that all and only mental phenomena are intentional, or that nothing physical is intentional. These views are, however, distinct from the view that all mental phenomena are intentional. For holding that all mental phenomena are intentional does not imply that nothing nonmental is.2 And holding that all mental phenomena are intentional does not imply (pace Dennett 1969) that nothing physical is intentional; since if physicalism were true, then the mental itself would be physical. What I am concerned with here, however, is the idea that all mental states are intentional, regardless of whether anything else is, or whether anything physical is. In recent years there has been considerable debate over whether all mental states are intentional; in particular, over whether all conscious mental states are intentional or entirely intentional. (shrink)

This study investigates the types of misinformation spread on Twitter that evokes scientific authority or evidence when making false claims about the antimalarial drug hydroxychloroquine as a treatment for COVID-19. Specifically, we examined tweets generated after former U.S. President Donald Trump retweeted misinformation about the drug using an unsupervised machine learning approach called the biterm topic model that is used to cluster tweets into misinformation topics based on textual similarity. The top 10 tweets from each topic cluster were content coded (...) for three types of misinformation categories related to scientific authority: medical endorsements of hydroxychloroquine, scientific information used to support hydroxychloroquine’s use, and a comparison group that included scientific evidence opposing hydroxychloroquine’s use. Results show a much higher volume of tweets featuring medical endorsements and use of supportive scientific information compared to accurate and updated scientific evidence, that misinformation-related tweets propagated for a longer time frame, and the majority of hydroxychloroquine Twitter discourse expressed positive views about the drug. Metadata from Twitter accounts found that prominent users within misinformation discourse were more likely to have media or political affiliation and explicitly expressed support for President Trump. Conversely, prominent accounts within the scientific opposition discourse primarily consisted of medical doctors or scientists but had far less influence in the Twitter discourse. Implications of these findings and connections to related social media research are discussed, as well as cognitive mechanisms for understanding susceptibility to misinformation and strategies to combat misinformation spread via online platforms. (shrink)

We can find in Henry David Thoreau’s work a response to Cartesian skepticism. Thoreau takes this skepticism to get its start in us only when we are not attuned to the world, that is, only when we lose sight of our being integrated with the world in the way we quite naturally are. Thoreau posits for human beings a natural and unshakeable integration with the world. This develops into an attunement with the world, making us ready to engage with the (...) world as mature epistemic agents. Yet even if we fall out of attunement with the world, perhaps in response to the reasonableness of a comprehensive doubt, our natural integration with the world remains. Skepticism lacks force because we are integrated with the world even when we are not attuned to it, and because our integration with the world can always help us return to a healthy epistemic engagement with the world. (shrink)

Alexander Maconochie, the originator of the “Mark System”, is a major figure in the history of penal discipline and is best known for his attempt to implement it at the Norfolk Island penal station from 1840 to 1844. Among Maconochie’s many works is the eight-page “Comparison Between Mr. Bentham’s Views on Punishment, and Those Advocated in Connexion with the Mark System”, in which Maconochie rejected Bentham’s critique of transportation, as well as fundamental elements of his theory of punishment. Maconochie concluded (...) that mainstream thinking on penal discipline was dominated by “mistakes” that either “in great measure originat[ed] with Mr. Bentham”, or had been “at least sanctioned by his high authority”.This paper questions whether Maconochie’s rejection of Bentham’s views is entirely convincing, since his penal practices, as well as an earlier and lesser-cited work, indicate that Maconochie was, at times, considerably closer to Bentham’s position on punishment than “Comparison” suggests. Section I will provide some brief biographical background. Section II will explore Maconochie’s attempt to implement his reformative system at Norfolk Island, at the heart of which was surveillance and extensive record-keeping to monitor individual behaviour and progress, and in which there are echoes of Bentham’s panopticon scheme. Section III will examine Maconochie’s changing views on criminal transportation, from his adherence to the Benthamite anti-transportation line in 1818, to his qualified support for transportation from 1838 onwards. Finally, Section IV will examine the Mark System and Maconochie’s criticism of Bentham in more detail. (shrink)

Melanie presented at twenty weeks of gestation to an obstetrics clinic in a critical access hospital in rural Vermont. She was excited to undergo routine fetal ultrasonography, but her obstetrician gave her grave news: the ultrasound revealed hypoplastic left heart syndrome, a devastating congenital heart defect. Initially, Melanie agreed in general to pursue surgical care for her fetus—a three‐stage process that has somewhat uncertain results and could only be done in tertiary care facilities far from her home in Vermont. A (...) week later, while the maternal fetal medicine and pediatric cardiology units made arrangements with colleagues in Boston, Melanie began having second thoughts. An ethics meeting was called to discuss conflicting clinician reactions to Melanie's dilemma. Most of the clinicians were stunned that the patient would change her mind. What advice should the ethics consultant offer the team about caring for Melanie? (shrink)

What does it mean to say that the demands of justice are institutional rather than individual? Justice is often thought to be directly concerned only with governmental institutions rather than individuals’ everyday, legally permissible actions. This approach has been criticized for ignoring the relevance to justice of informal social norms. This paper defends the idea that justice is distinctively institutional but rejects the primacy of governmental institutions. I argue that the ‘pervasive structure of society’ is the site of justice and (...) injustice. It includes all widely enforced social rules and norms, governmental and otherwise, such as informal norms of gender, language and class, and provides a revisionary foundation for the theoretical elucidation and practical pursuit of justice. It provides a framework for evaluating the ways in which people can and should promote justice in their everyday lives. (shrink)

This article analyses individual level support for a Basic Income Guarantee (BIG) using the European Social Survey. At the country level, support is highest in South and Central Eastern Europe, but variation does not otherwise seem to follow established differences between varieties of capitalisms or welfare state regimes. At the individual level, findings are broadly in line with the expectations of the political economy literature. Left-leaning individuals facing high labour market risk and/or on low incomes are more supportive of a (...) BIG, whereas current union members are less likely to support a BIG, consistent with the insider-outsider literature. However, when controlling for confounding variables, union membership is not statistically significant, suggesting that it is not membership per se, but the characteristics of unionised workers that make them less supportive. In many countries, a coalition between centrist and left-leaning individuals therefore seems most promising, but its political feasibility depends on whether enough union members are favourable to a BIG and on the level of opposition from high income and/or conservative parts of the electorate. (shrink)

Human development is a matter of complex interactions between nutritional regimes, genes, educational regimes and other diverse developmental resources. I argue that there is no ethically salient difference between the contributions made to development by genes and the contributions made by these other resources. Since we think nutrition and schooling should be included in the calculus of distributive justice, we should include at least some genes in this calculus too. What is more, under the right circumstances genetic engineering may become (...) a useful tool for the distribution of developmental resources. This said, attention to the parity of genetic and environmental causation can also help to articulate the legitimate suspicions many groups have of genetic engineering. (shrink)

Summary The aim of this paper is three-fold. Firstly, to briefly set out how strategic choices made about theorising about intentionality or content have actions at a distance for accounting for delusion. Secondly, to investigate how successfully a general difficulty facing a broadly interpretative approach to delusions might be eased by the application of any of three Wittgensteinian interpretative tools. Thirdly, to draw a general moral about how the later Wittgenstein gives more reason to be pessimistic than optimistic about the (...) prospects of a philosophical psychopathology aimed at empathic understanding of delusions. (shrink)

Given an admissible indexing φ of the countable atomless Boolean algebra B, an automorphism F of B is said to be recursively presented (relative to φ) if there exists a recursive function $p \in \operatorname{Sym}(\omega)$ such that F ⚬ φ = φ ⚬ p. Our key result on recursiveness: Both the subset of $\operatorname{Aut}(\mathscr{B})$ consisting of all those automorphisms which are recursively presented relative to some indexing, and its complement, the set of all "totally nonrecursive" automorphisms, are uncountable. This arises (...) as a consequence of the following combinatorial investigations: (1) A comparison of the cycle structures of f and f̄, where f is a permutation of some free basis of B and f̄ is the automorphism of B induced by f. (2) An explicit description of the permutations of ω whose conjugacy classes in $\operatorname{Sym}(\omega)$ are (a) uncountable, (b) countably infinite, and (c) finite. (shrink)

The paper introduces a new type of rules into Natural Deduction, elimination rules by composition. Elimination rules by composition replace usual elimination rules in the style of disjunction elimination and give a more direct treatment of additive disjunction, multiplicative conjunction, existence quantifier and possibility modality. Elimination rules by composition have an enormous impact on proof-structures of deductions: they do not produce segments, deduction trees remain binary branching, there is no vacuous discharge, there is only few need of permutations. This new (...) type of rules fits especially to substructural issues, so it is shown for Lambek Calculus, i.e. intuitionistic non-commutative linear logic and to its extensions by structural rules like permutation, weakening and contraction. Natural deduction formulated with elimination rules by composition from a complexity perspective is superior to other calculi. (shrink)

Recent models of cognition in Posttraumatic Stress Disorder predict that trauma-related, but not neutral, processing should be differentially affected in these patients, compared to trauma-exposed controls. This study compared a group of 50 patients with PTSD related to the war in Bosnia and a group of 50 controls without PTSD but exposed to trauma from the war, using the DRM method to induce false memories for war-related and neutral critical lures. While the groups were equally susceptible to neutral critical lures, (...) the PTSD group mistakenly recalled more war-related lures. Both false and correct recall were related more to depression than to self-rated trauma. Implications for accounts of false memories in terms of source-monitoring are discussed. (shrink)

In 1935/1936 Kurt Gödel wrote three notebooks on the foundations of quantum mechanics, which have now been entirely transcribed for the first time. Whereas a lot of the material is rather technical in character, many of Gödel's remarks have a philosophical background and concentrate on Leibnizian monadology as well as on vitalism. Obviously influenced by the vitalistic writings of Hans Driesch and his ‘proofs’ for the existence of an entelechy in every living organism, Gödel briefly develops the idea of a (...) computing machine which closely resembles Turing's groundbreaking conception. After introducing the notebooks on quantum mechanics, this article describes Gödel's vitalistic Weltbild and the ideas leading to the development of his computing machine. It investigates a notion of lawlike sequence which closely resembles Turing's concept of a computable number and which Gödel himself calls ‘problematic’, and compares it to the opposed concept of randomness, drawing upon the notion of program-size complexity. Finally, Gödel's machine is implemented in a dialect of the Lisp programing language. (shrink)

Alzheimer's disease is the most common neurodegenerative disorder in today's developed world that is also increasingly picked out as a focal theme in fictional literature. In dealing with the subjectivity of human experience, such literature enhances the reader's empathy and is able to teach about moral, emotional and philosophical issues, offering the chance to see situations from a position otherwise possibly never taken by the reader. The understanding and insight so gained may well be unscientific, but the literary approach offers (...) an insight into the whole person's perspective and the particularity and uniqueness of a situation that includes ethical conflicts. A key motif of fictional literature centred around dementia remains the burden the adult-child carer is confronted with, considering the parent's remorseless decline and personality change, the sudden demand for devoted and continuous care, and the constantly changing relationship with the declining parent. In the context of an ever increasing demand for a constructive public discussion regarding end-of-life treatment of demented patients, Christine Devars (Le Piano Désaccordé) and Andrés Barba (Ahora Tocad Música de Baile) illustrate how powerful and burdensome the impact of Alzheimer's disease is on both patient and carer and what extremes may be reached under such truly exceptional circumstances. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Violations of Bell's Inequality can only be reliably produced if some information about the apparatus setting on one wing is available on the other, requiring superluminal information transmission. In this paper I inquire into the minimum amount of information needed to generate quantum statistics for correlated photons. Reflection on informational constraints clarifies the significance of Fine's Prism models, and allows the construction of several models more powerful than Fine's. These models are more efficient than Fine claims to be possible and (...) work for the full range of possible analyzer settings. It also demonstrates that the division of theories into those that violate parameter independence and those that violate outcome independence sheds no light on the question of superluminal information transmission. (shrink)

As Nietzsche famously declared, only that which has no history can be defined. Robert Sparling's superb book shows that corruption is a concept with a history. Although Political Corruption is ordered chronologically, it is expressly not a linear account of how one modern definition of corruption evolved. History instead discloses how the concept has been deployed in a variety of modes in occidental political philosophy, seven of which are recovered here: from Erasmus's focus on the moral integrity of the prince (...) to Weber's ethics of bureaucratic office, via Machiavelli, Étienne de la Boétie, Bolingbroke, Robespierre, and Kant. Pursuant to the book's nonlinearity, these philosophers are not placed in conversation... (shrink)

This paper discusses a role playing ethics case suitable for business students in which participants must balance shareholder and stakeholder concerns. Students take on the role of operations manager and are challenged to consider the effects of their choices on the local society as they balance the demands of stockholders, employees, and family when the concerns of the groups come into conflict. The exercise helps students understand the need to consider the ethicalcomponents of business decisions and the difficulties of handling (...) values in conflict. Students learn more about their own values through playing the role of manager. Suggested discussion questions are provided. This note also reviews some of the extant literature on the goals of stakeholder versus shareholder wealth and the role of ethics, and it discusses areas of common ground between the stakeholder/shareholder theories. (shrink)

This paper discusses a role playing ethics case suitable for business students in which participants must balance shareholder and stakeholder concerns. Students take on the role of operations manager and are challenged to consider the effects of their choices on the local society as they balance the demands of stockholders, employees, and family when the concerns of the groups come into conflict. The exercise helps students understand the need to consider the ethicalcomponents of business decisions and the difficulties of handling (...) values in conflict. Students learn more about their own values through playing the role of manager. Suggested discussion questions are provided. This note also reviews some of the extant literature on the goals of stakeholder versus shareholder wealth and the role of ethics, and it discusses areas of common ground between the stakeholder/shareholder theories. (shrink)

This essay examines the variety of ways that historians have engaged with material culture in their work over the last few decades. Although textual records from the archive remain privileged sources, the diversity of historiographical approach has led to a range of historiographical practices including a material turn. Two major approaches to objects have dominated. Dubbed ‘object driven’ and ‘object centred’, these variously use objects as evidence for a very wide range of research questions, and focus on past material cultures (...) respectively. Focusing on a case study of Holocaust historiography, the essay identifies the challenges for contemporary archaeology generated by these two historiographical traditions, as well as by the self-reflectivity over narrating material pasts/past materialities that characterizes historical practice. (shrink)

This book offers a side-by-side consideration of two competing interpretations of Confucius' ethical teachings in the Analects, ultimately arguing that Confucius’ ethics has important things to teach us about both our inner character traits and our social roles.

Psychiatric diagnosis depends, centrally, on the transmission of patients’ knowledge of their experiences and symptoms to clinicians by testimony. In the case of non-native speakers, the need for linguistic interpretation raises significant practical problems. But determining the best practical approach depends on determining the best underlying model of both testimony and knowledge itself. Internalist models of knowledge have been influential since Descartes. But they cannot account for testimony. Since knowledge by testimony is possible, and forms the basis of psychiatric diagnosis, (...) its very existence is a factor in support of an externalist model of knowledge in general. Internalist and externalist models of knowledge also suggest different ways of responding to the practical challenges of basing psychiatric diagnosis on testimony. Thus the argument in favour of externalism also supports a potentially empirically testable hypothesis about interpretation of non-native speakers for accurate psychiatric diagnosis: interpretation of non-English speakers should be as transparent and unhindered by specialised medical knowledge as possible. (shrink)