Pyridoxal 5′‐phosphate, the vitamin B6 derivative, acts as the coenzyme of many enzymes involved in amino acid metabolism. Exceptionally, this compound was found covalently bound to glycogen phosphorylase, the key enzyme in the regulation of glycogen metabolism. Although it is essential for the function of phosphorylase, its direct role has remained an enigma. We have recently found that the glucose moiety of pyridoxal (5′)diphospho (1)‐α‐D‐glucose, a conjugate of pyridoxal 5′‐phosphate and glucose 1‐phosphate through a pyrophosphate linkage, is transferred to the (...) nonreducing end of glycogen, forming a new α‐1,4‐glucosidic linkage. This finding emphasizes the importance of the direct phosphate‐phosphate interaction between the coenzyme and the substrate in the phosphorylase catalytic reaction. We have proposed a catalytic mechanism for phosphorylase in which the phosphate group of pyridoxal 5′‐phosphate acts as an electrophile to the phosphate group of glucose 1‐phosphate. This appears to represent the first instance of the direct involvement of a phosphate group in catalysis by enzymes. (shrink)

Universities are increasingly part of wider geographical processes including international, national and sub-national actors. Universities now find themselves having to pay attention to many more political centres than before, as seen, for example, with research grants, assessments and teaching accreditation from transnational bodies, individual states and regional authorities. As an institution, the university constitutes a place which needs to be situated within a wider space and the geography of power-relations. This article traces these spatial developments in relation to recent policy (...) changes in the Japanese context. The current university reforms, set against the development of the globalising knowledge-based economy and regionalization of innovation policies, are examined in relation to the changing role of universities in multi-spacial innovation systems. (shrink)

Writing Technology in Meiji Japan: A Media History of Modern Chinese Literature and Visual Culture. By Seth Jacobowitz. Harvard East Asian Monographs, vol. 387. Cambridge, Mass.: Harvard University Asia Center, Harvard University Press, 2015. Pp. xii + 299. $39.95.

This paper offers some ideas and methods of consensus building towards integration of values in flood control, environment, and landscape. These three factors sometimes oppose to each other in the process of construction of public infrastructure such as roadbuilding and river improvement. It is crucial to avoid or resolute conflicts between the government and the local people through project management with the consensus building process. In public works in Japan, flood control has been given priority over the environmental preservation and (...) the landscape conservation due to the perception that it is through flood control that the life and property of individuals are adequately protected. As a consequence, the landscape and the environment have been paid only lip‐service. In the case of the Ohashi River Project in Izumo region presented in this paper, however, the river repair process might entail a severe blow to the tourism industry and have a dramatic impact on the fishery resources of the region, which would be considered a major loss in terms of the urban development of the city. One of our concerns is thus to avoid any losses, through proper consideration of the relationship between the three crucial factors. In this paper, the author reports some ideas and methods that appear in “Basic Policy for the Development of the Area around Ohashi River” composed by the Matsue Review Committee on the Development of the Area around the Ohashi River, in which the author is involved as a committee member. The most important task of the Committee wasto search for the ideas and methods to harmonize the values of flood control, environment, and landscape. (shrink)

We consider minimal ranks of extenders associated with Shelah cardinals by introducing witnessing numbers. Using these numbers we shall investigate effects of Shelah cardinals above themselves. MSC: 03E55.

Contributed articles presented at the Conference in Japanese and other languages, translated into English.

西田幾多郎の哲学は、単なる宗教体験の表現ではない合理的世界観である。その全貌を解読する時、われわれは、西田哲学が封印したもう一つの視点を発見する。そこであらわになるのは、驚くべき「時間」の真相―時間幻 想である。.

This note is a continuation of our former paper ''Complexity of the r-query tautologies in the presence of a generic oracle.'' We give a very short direct proof of the nonexistence of t-generic oracles, a result obtained first by Dowd. We also reconstitute a proof of Dowd's result that the class of all r-generic oracles in his sense has Lebesgue measure one.