Official documents, such as the Word Anti-Doping Code (WADC), argue that sport can be deemed a homogenous and unitary concept. Even where different sports have varying characteristics, the homogenous view of a given sport (‘a sport’ or ‘the sport’) persists. The WADC, international and national sport associations aim to protect the spirit of (the) sport. In this picture, the intersection of sporting integrity and legal processes occupies a vital place. The article will posit that, from a legal perspective sport is (...) heterogeneous due to its governance, regulation, adjudication, and enforcement structures. International and national associations, such as sport federations and leagues, have separate normative orders. These normative orders lead to differences in ensuring sporting integrity. A plural normative environment is inherent in sport; thus, we need to deal with it. The article will conclude that although harmonising norms and interpretations related to sporting integrity through national and global institutions may be acceptable, these must be achieved by promoting good governance and human rights. (shrink)

Iritări cotidiene -- Actualităţi, inactualităţi -- Mici exerciţii de memorie -- Despre patosul real al interogaţiei religioase -- Neliniști (politice) -- Bazarul naţional -- Privitor ca la teatru -- Unele perplexităţi.

This paper reports two cases in Hong Kong involving two native Chinese adolescent cancer patients (APs) who were denied their rights to consent to necessary treatments refused by their parents, resulting in serious harm. We argue that the dynamics of the 'AP-physician-family-relationship' and the dominant role Chinese families play in medical decision-making (MDM) are best understood in terms of the tendency to hierarchy and parental authoritarianism in traditional Confucianism. This ethic has been confirmed and endorsed by various Chinese writers from (...) Mainland China and Hong Kong. Rather than giving an unqualified endorsement to this ethic, based more on cultural sentimentalism than rational moral reasoning, we warn that a strong familism in MDM, which deprives 'weak' family members of rights, represents the less desirable elements of this tradition, against which healthcare professionals working in this cultural milieu need to safeguard. Specifically for APs, we suggest that parental authority and family integrity should be re-interpreted in terms of parental responsibility and the enhancement of children's interests respectively, as done in the West. This implies that when parents refuse to consent to necessary treatment and deny their adolescent children's right to consent, doctors, as the only remaining advocates of the APs' interest, have the duty to inform the state, which can override parental refusal to enable the doctors to fulfill their professional and moral obligations. In so doing the state exercises its 'parens patriae' power to defend the defenseless in society and the integrity of the medical profession. (shrink)

Nicolas Malebranche (1638–1715) holds that the senses, imagination, and passions aim at survival and the satisfaction of the body’s needs, rather than truth or the good of the mind. Each of these faculties makes a distinctive and, indeed, an indispensable contribution to the preservation of life. Commentators have largely focused on how the senses keep us alive. By comparison, the imagination and passions have been neglected. In this paper, I reconstruct Malebranche’s account of how the imagination contributes to the preservation (...) of the body by compensating for the limitations of the senses. First, the imagination represents non-actual states of affairs, such as probable or possible future states. Second, the imagination forges new and often helpful associations based on past experiences. Third, the imagination (mis)represents that objects will cause pleasure and pain, thereby imbuing them with emotional significance they would otherwise lack. Together, these features flesh out Malebranche’s view that the imagination is necessary for the preservation of life. (shrink)

Targeted gene alteration (TGA) is a strategy for correcting single base mutations in the DNA of human cells that cause inherited disorders. TGA aims to reverse a phenotype by repairing the mutant base within the chromosome itself, avoiding the introduction of exogenous genes. The process of how to accurately repair a genetic mutation is elucidated through the use of single‐stranded DNA oligonucleotides (ODNs) that can enter the cell and migrate to the nucleus. These specifically designed ODNs hybridize to the target (...) sequence and act as a beacon for nucleotide exchange. The key to this reaction is the frequency with which the base is corrected; this will determine whether the approach becomes clinically relevant or not. Over the course of the last five years, workers have been uncovering the role played by the cells in regulating the gene repair process. In this essay, we discuss how the impact of the cell on TGA has evolved through the years and illustrate ways that inherent cellular pathways could be used to enhance TGA activity. We also describe the cost to cell metabolism and survival when certain processes are altered to achieve a higher frequency of repair. (shrink)

Sredi I︠A︡, MY i ONI -- Na kremnistom puti -- V dialektike gumanizma -- S kli︠u︡chami sovesti.

Living in a province dominated by powerful oligarchs, Giambattista Vico (1668–1744) concluded that political philosophy should work to undermine aristocratic authority and prevent political devolution into feudalism. Rejecting the possibility that the free market could successfully instill civil behavior, he advocated for a strong central judicial system to work closely with citizens to promote stability and justice. This study puts Vico in conversation with other Enlightenment thinkers such as Locke, Rousseau, and Mandeville to show how his alternative warrants serious consideration. (...) In contrast to scholars who read Vico's New Science as a defense of the imagination, this study casts his account of poetic wisdom politically as an epistemological critique of the aristocratic mentality. Myth and Authority argues that Vico's depiction of pagan religion is a refined attempt to explain how oligarchy maintains its stranglehold on power. While Western civilization did not follow the path Vico suggested, it may now be more relevant as concerns grow about the increasing influence of the wealthy on civil institutions. (shrink)

Psychoanalysis had a profound influence on formation of Merleau-Ponty’s thought. However, at the same time, he rejects Freud’s idea that the unconscious consists of latent mental contents that cause a certain type of behavior. Instead of a hidden experience, Merleau-Ponty argues that the unconscious is an ambiguous consciousness. In The Structure of Behavior and The Phenomenology of Perception, he specifies this ambiguity by means of the concepts of habit, bad faith, bodily expression, affective intentionality and body schema. In this paper, (...) I will present the interconnection of these aspects of the human existence, following Merleau-Ponty’s two early major works. Further, I will show the difference of Merleau-Ponty’s notion of bad faith from that of Sartre, and, finally, I will suggest a limitation of Merleau-Ponty’s approach to the unconscious. (shrink)