IntroductionBrain tumours frequently cause language impairments and are also likely to co-occur with localised abnormal slow-wave brain activity. However, it is unclear whether this applies specifically to low-grade brain tumours. We investigate slow-wave activity in resting-state electroencephalography in low-grade glioma and meningioma patients, and its relation to pre- and postoperative language functioning.MethodPatients with a glioma infiltrating the language-dominant hemisphere and patients with a meningioma with mass effect on this hemisphere underwent extensive language testing before and 1 year after surgery. EEG (...) was registered preoperatively, postoperatively, and once in healthy individuals. Slow-wave activity in delta- and theta- frequency bands was evaluated visually and quantitatively by spectral power at three levels over the scalp: the whole brain, the affected hemisphere, and the affected region.ResultsGlioma patients had increased delta activity and increased theta activity before and after surgery. In these patients, increased preoperative theta activity was related to the presence of language impairment, especially to poor word retrieval and grammatical performance. Preoperative slow-wave activity was also related to postoperative language outcomes. Meningioma patients showed no significant increase in EEG slow-wave activity compared to healthy individuals, but they presented with word retrieval, grammatical, and writing problems preoperatively, as well as with writing impairments postoperatively.DiscussionAlthough the brain-tumour pathology in low-grade gliomas and meningiomas has a different effect on resting-state brain activity, patients with low-grade gliomas and meningiomas both suffer from language impairments. Increased theta activity in glioma patients can be considered as a language-impairment marker, with prognostic value for language outcome after surgery. (shrink)

This book will be a rewarding reading for everybody who is interested in logical aspects of scientific knowledge acquisition. The presentation of the issues discussed in the book is exemplary. The author was able to present in parallel way three different perspectives under which the issues discussed in the book might be approached.

One of the themes that has been widely addressed in both the implicit learning and statistical learning literatures is that of rule learning. While it is widely agreed that the extraction of regularities from the environment is a fundamental facet of cognition, there is still debate about the nature of rule learning. Rey and colleagues show that the comparison between human and non‐human primates can contribute important insights to this debate.

According to some authors, emotions can be unconscious when they are unfelt or unnoticed. According to others, emotions are always conscious because they always have a phenomenology. The aim of this paper is to resolve the ongoing debate about the possibility for emotions to be unfelt. To do so, I focus on the notion of “unconscious emotions”. While this notion appears paradoxical, by way of a distinction between two meanings of emotional consciousness I show that it is not so. These (...) meanings are both compatible with the leading views of consciousness and they do not require one to distinguish different senses of “emotions” or “consciousness”. This distinction is helpful to define how emotions can be unconscious. (shrink)

The goal with these questions is to gain a sense of what contemporary epistemology is up to and its broader intellectual environment , with particular emphasis on the meeting point between mainstream and formal epistemology.

The aim of this paper is to demonstrate how methodological insights from formal and modal learning theory have a significant bearing on the classical definition of knowledge as true justified belief.

Résumé Lors d’un procès, les questions introductives en début d’interrogatoire peuvent aider non seulement à mettre le témoin à l’aise, mais également à le personnaliser, c’est-à-dire de le présenter sous un jour particulier, ce qui peut jouer sur sa crédibilité et l’empathie du décideur à son endroit. Cet article vise à mettre en évidence les mécanismes discursifs sous-jacents à ce processus et à illustrer empiriquement comment les réponses aux questions introductives y participent. À l’aide de l’approche ventriloque de la communication, (...) un extrait du témoignage d’un ex-maire de la ville de Montréal à la Commission Charbonneau est analysé en profondeur. L’analyse que nous proposons contribue à mieux comprendre ce qui se joue lors d’un témoignage, celui-ci devenant, selon notre perspective, ce lieu constamment disloqué dans lequel plusieurs figures se mettent à littéralement faire des choses et dire des choses afin qu’un témoin gagne ou perde la faveur du décideur. (shrink)

L’article entend montrer qu’à partir d’une conceptualité classique, héritée de Descartes, Spinoza parvient à contrer l’argument cartésien de liberté et l’argument aristotélicien du finalisme par une structure théorique impossible à classifier à son époque, faisant penser à une tentative de formaliser l’auto-organisation comme le fondement de l’intentionnalité. À partir d’une analyse du texte spinoziste et sa compréhension de la _contrainte_, l’article entend montrer que la reprise d’un certain nombre de notions et de termes entourant ce thème ont été redisposés par (...) Spinoza afin de solutionner un problème nouveau, invisible avant lui. (shrink)

The unexpected passing of United States Supreme Court Justice Antonin Scalia left a vacancy on the Court in the midst of a presidential election year. As a result, the appointment process did not proceed in the same fashion as previous appointments. Instead, the Senate declared shortly after Justice Scalia’s death that it would not consider any candidate to fill the vacancy until the next president is elected. The Senate remained steadfast in this decision throughout the remainder of President Obama’s term. (...) -/- This Article analyzes the constitutional questions surrounding the Senate’s refusal to consider any nominee and argues the Senate has a duty to advise and consent in a timely manner. Additionally, it demonstrates how a politically-motivated delay threatens the integrity of the constitutional process for selecting judges, violates separation of powers concerns by politicizing the Court, and contradicts the express intent of the Framers of the Constitution. (shrink)

Charles S. Peirce has a great deal to contribute both to understanding and to solving many of the philosophical problems which puzzle contemporary thinkers. In fact it is probably true that in some ways philosophers of our time are in a better position to understand Peirce's thought than those of his own day. In this paper I would like to consider two puzzling notions: 1) the substantiality of things, and 2) the foundations of human knowledge.

In de filosofische traditie is de materiële aarde als thema altijd onderbelicht gebleven. Van Aristoteles en Descartes tot Nietzsche en Heidegger blijkt de aarde altijd te zijn gedacht vanuit de vorm, vanuit het denken of vanuit de wereld. Hierdoor is de aarde als passief, inert of zelfs niet-bestaand beschouwd, maar niet vanuit zichzelf. In tijden van ecologische crisis en klimaatverandering is deze manier van denken niet langer toereikend. We moeten toe naar een nieuwe omgang met de aarde. Van wereld naar (...) aarde biedt hiertoe een eerste aanzet. -/- Ecologische ontologie Vincent Blok ontwikkelt een ecologische ontologie van de aarde in tijden van klimaatverandering. Hij gaat in tegen de filosofische traditie door zijn ontologie niet antropocentrisch, maar eco-centrisch te oriënteren. Vervolgens presenteert hij een speculatieve ecologie van de aarde als mogelijkheidsvoorwaarde voor de menselijke bewoning van de wereld. Zijn nieuwe perspectief op onze zorg voor de aarde biedt relevante inzichten voor de milieu- en techniekfilosofie. (shrink)

It is generally assumed that the developmental program of embryogenesis relies on epigenetic mechanisms. However, a mechanistic link between epigenetic marks and cell fate decisions had not been established so far. In a recent article, Torres‐Padilla and colleagues1 show that epigenetic information and, more precisely, histone arginine methylation mediated by CARM1 could contribute to cell fate decisions in the mouse 4‐cell‐stage embryo. It provides the first indications that global epigenetic information influences allocation of pluripotent cells toward the first cell lineages. (...) BioEssays 29:520–524, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

'Possible worlds' have been one of the true conundrum notions in philosophy. On the hand possible worlds have proved very useful in philosophical logic for obtaining significant formal results with sunbstantial philosophical import. Yet on the other they have generated much noise and commotion in especially metaphysics and epistemology. From a logical point of view they are useful tools or conceptual constructions, from a philosophical point of view troublesome entitites generating endless discussions.

Dans quelles circonstances et pourquoi Robert K. Merton a-t-il rencontré l’idée de serendipity? Quelle place occupe-t-elle dans son œuvre? Cet article propose de reconstituer pas à pas l’histoire de cette rencontre, qui ne manque pas d’ironie ni de piquant. En elle-même « sérendipienne », la découverte accidentelle mais tellement féconde du mot serendipity ouvrit à Merton nombre de pistes de recherche au cours des années 1940. Le concept intrigant de la découverte fortuite qui – entre autres vertus – engendre des (...) résultats de nature à transformer la théorie promettait d’enrichir et de renouveler la connaissance objective. Mais la serendipity était plus qu’une recette heuristique à appliquer en science. Chez Merton, c’était aussi l’objet privilégié et « auto-exemplifiant » d’une sémantique sociologique des concepts, dont l’ambition est d’étudier les itinéraires des terminologies dans la culture. En retraçant la genèse de la recherche qu’il mena avec Elinor Barber sur l’histoire du mot et des significations parfois volatiles de la serendipity, on parviendra à saisir pourquoi ce thème revêtait pour Merton un double intérêt stratégique, à la fois épistémologique et autobiographique. On comprendra aussi pourquoi une nouvelle traduction en français du premier fragment d’article dans lequel le sociologue conceptualise la serendipity en 1948 est de bonne méthode sérendipienne. (shrink)

This paper suggests that autistic people relate to themselves via a third-person perspective, an objective and explicit mode of access, while neurotypical people tend to access the different dimensions of their self through a first-person perspective. This approach sheds light on autistic traits involving interactions with others, usage of narratives, sensitivity and interoception, and emotional consciousness. Autistic people seem to access these dimensions through comparatively indirect and effortful processes, while neurotypical development enables a more intuitive sense of self.