The aim of synthetic biology is to rationally design devices, systems, and organisms with desired innovative and useful functions (Slusarczyk, Lin, and Weiss 2012). To achieve this aim, synthetic biology uses a concept similar to engineering sciences: well-characterized and standardized modular biological building blocks are reassembled in a systematic and rational manner to generate complex devices and systems with a predicted function. In the past, molecular biological research in combination with intense work in new research areas like systems biology and (...) functional genomics revealed a large inventory of multifaceted modular biological parts that are now in the toolboxes of synthetic biologists. Due to .. (shrink)

Objects which a human agent controls by efferent activities can be perceived by the agent as belonging to his or her body. This suggests that what an agent counts as “body” is plastic, depending on what she or he controls. Yet there are possible limitations for such momentary plasticity. One of these limitations is that sensations stemming from the body and sensations stemming from objects outside the body are not integrated if they do not sufficiently “match”. What “matches” and what (...) does not is conceivably determined by long–term experience with the perceptual changes that body movements typically produce. Children have accumulated less sensorimotor experience than adults have. Consequently, they express higher flexibility to integrate body-internal and body-external signals, independent of their “match” as suggested by rubber hand illusion studies. However, children’s motor performance in tool use is more affected by mismatching body-internal and body-external action effects than that of adults, possibly because of less developed means to overcome such mismatches. We review research on perception-action interactions, multisensory integration, and developmental psychology to build bridges between these research fields. By doing so, we account for the flexibility of the sense of body ownership for actively controlled events and its development through ontogeny. This gives us the opportunity to validate the suggested mechanisms for generating ownership by investigating their effects in still developing and incomplete stages in children. We suggest testable predictions for future studies investigating both body ownership and motor skills throughout the lifespan. (shrink)

Hilbert's finitist program was not created at the beginning of the twenties solely to counteract Brouwer's intuitionism, but rather emerged out of broad philosophical reflections on the foundations of mathematics and out of detailed logical work; that is evident from notes of lecture courses that were given by Hilbert and prepared in collaboration with Bernays during the period from 1917 to 1922. These notes reveal a dialectic progression from a critical logicism through a radical constructivism toward finitism; the progression has (...) to be seen against the background of the stunning presentation of mathematical logic in the lectures given during the winter term 1917/18. In this paper, I sketch the connection of Hilbert's considerations to issues in the foundations of mathematics during the second half of the 19th century, describe the work that laid the basis of modern mathematical logic, and analyze the first steps in the new subject of proof theory. A revision of the standard view of Hilbert's and Bernays's contributions to the foundational discussion in our century has long been overdue. It is almost scandalous that their carefully worked out notes have not been used yet to understand more accurately the evolution of modern logic in general and of Hilbert's Program in particular. One conclusion will be obvious: the dogmatic formalist Hilbert is a figment of historical (de)construction! Indeed, the study and analysis of these lectures reveal a depth of mathematical-logical achievement and of philosophical reflection that is remarkable. In the course of my presentation many questions are raised and many more can be explored; thus, I hope this paper will stimulate interest for new historical and systematic work. (shrink)

Hendrik Lorenz presents a comprehensive study of Plato's and Aristotle's conceptions of non-rational desire. They see this as something that humans share with animals, and which aims primarily at the pleasures of food, drink, and sex. Lorenz explores the cognitive resources that both philosophers make available for the explanation of such desires, and what they take rationality to add to the motivational structure of human beings. In doing so, he finds conceptions of the mind that are coherent and (...) deeply integrated with both philosophers' views about such topics as the relation between body and soul, or the nature of the virtues. (shrink)

Wilfred Sieg. Mechanical Procedures and Mathematical Experience.

Hugely controversial on publication, this is an insightful and characteristically entertaining survey of animal behaviour and the evolution of aggression throughout the animal world.

On June 4, 1925, Hilbert delivered an address to the Westphalian Mathematical Society in Miinster; that was, as a quick calculation will convince you, almost exactly sixty years ago. The address was published in 1926 under the title Über dasUnendlicheand is perhaps Hilbert's most comprehensive presentation of his ideas concerning the finitist justification of classical mathematics and the role his proof theory was to play in it. But what has become of the ambitious program for securing all of mathematics, once (...) and for all? What of proof theory, the very subject Hilbert invented to carry out his program? The Hilbertian ambition reached out too far: in its original form, the program was refuted by Gödel's Incompleteness Theorems. And even allowing more than finitist means in metamathematics, the Hilbertian expectations for proof theory have not been realized: a constructive consistency proof for second-order arithmetic is still out of reach. Nevertheless, remarkable progress has been made. Two separate, but complementary directions of research have led to surprising insights: classical analysis can be formally developed in conservative extensions of elementary number theory; relative consistency proofs can be given by constructive means for impredicative parts of second order arithmetic. The mathematical and metamathematical developments have been accompanied by sustained philosophical reflections on the foundations of mathematics. This indicates briefly the main themes of the contributions to the symposium; in my introductory remarks I want to give a very schematic perspective, that is partly historical and partly systematic. (shrink)

Wilfred Sieg. Relative Consistency and Accesible Domains.

Wilfried Sieg and John Byrnes. AnModel for Parallel Computation: Gandy's Thesis.

"Dialogisches Handeln" ist eine Sammlung von philosophischen BeitrAgen zum dialogischen Konstruktivismus im Sinne von Kuno Lorenz, der Philosophie als eine Kommunikation mit Selbstreflexion versteht. Dabei umfaAt der Dialog in diesem Buch verschiedene Disziplinen der Philosophie - von der Anthropologie A1/4ber die Grundlagen von Logik und Sprachphilosophie bis hin zur Wissenschafts- und Erkenntnistheorie. Die Reflexion auf die kommunikativen Grundlagen wissenschaftlichen Austauschs schlieAt dabei Denkperspektiven verschiedener Wissenschaften - von der Psychologie bis zu Physik und Chemie - ebenso ein wie die philosophischen (...) Disziplinen. (shrink)

The incompleteness theorems constitute the mathematical core of Gödel’s philosophical challenge. They are given in their “most satisfactory form”, as Gödel saw it, when the formality of theories to which they apply is characterized via Turing machines. These machines codify human mechanical procedures that can be carried out without appealing to higher cognitive capacities. The question naturally arises, whether the theorems justify the claim that the human mind has mathematical abilities that are not shared by any machine. Turing admits that (...) non-mechanical steps of intuition are needed to transcend particular formal theories. Thus, there is a substantive point in comparing Turing’s views with Gödel’s that is expressed by the assertion, “The human mind infinitely surpasses any finite machine”. The parallelisms and tensions between their views are taken as an inspiration for beginning to explore, computationally, the capacities of the human mathematical mind. (shrink)

This commentary focuses on Hommel et al.'s inferences on action planning. It discusses the relevance of anticipated extrinsic movement effects for action control, the problems of a feature-based representation of actions, and the necessity of the acquisition of conditional movement-effect associations.

David Hilbert was one of the great mathematicians who expounded the centrality of their subject in human thought. In this collection of essays, Wilfried Sieg frames Hilbert's foundational work, from 1890 to 1939, in a comprehensive way and integrates it with modern proof theoretic investigations.

Wilfried Sieg. Calculations by Man and Machine: Mathematical Presentation.

In this paper, we consider certain cardinals in ZF (set theory without AC, the axiom of choice). In ZFC (set theory with AC), given any cardinals C and D, either C ≤ D or D ≤ C. However, in ZF this is no longer so. For a given infinite set A consider $\operatorname{seq}^{1 - 1}(A)$ , the set of all sequences of A without repetition. We compare $|\operatorname{seq}^{1 - 1}(A)|$ , the cardinality of this set, to |P(A)|, the cardinality of (...) the power set of A. What is provable about these two cardinals in ZF? The main result of this paper is that $ZF \vdash \forall A(|\operatorname{seq}^{1 - 1}(A)| \neq|\mathscr{P}(\mathscr{A})|)$ , and we show that this is the best possible result. Furthermore, it is provable in ZF that if B is an infinite set, then $|\operatorname{fin}(B)| <|\mathscr{P}(B)|$ even though the existence for some infinite set B* of a function f from $\operatorname{fin}(B^\ast)$ onto P(B*) is consistent with ZF. (shrink)

We establish by elementary proof-theoretic means the conservativeness of two subsystems of analysis over primitive recursive arithmetic. The one subsystem was introduced by Friedman [6], the other is a strengthened version of a theory of Minc [14]; each has been shown to be of considerable interest for both mathematical practice and metamathematical investigations. The foundational significance of such conservation results is clear: they provide a direct finitist justification of the part of mathematical practice formalizable in these subsystems. The results are (...) generalized to relate a hierarchy of subsystems, all contained in the theory of arithmetic properties, to a corresponding hierarchy of fragments of arithmetic. The proof theoretic tools employed there are used to re-establish in a uniform, elementary way relationships between various fragments of arithmetic due to Parsons, Paris and Kirby, and Friedman. (shrink)

The Heythrop Journal, Volume 63, Issue 3, Page 425-437, May 2022.

Wilfred Sieg and Dirk Schlimm. Dedekind's Analysis of Number: Systems and Axioms.

The Hygiene Hypothesis has been recognized as an important cornerstone to explain the sudden increase in the prevalence of asthma and allergic diseases in modernized culture. The recent epidemic of allergic diseases is in contrast with the gradual implementation of Homo sapiens sapiens to the present-day forms of civilization. This civilization forms a gradual process with cumulative effects on the human immune system, which co-developed with parasitic and commensal Helminths. The clinical manifestation of this epidemic, however, became only visible in (...) the second half of the twentieth century. In order to explain these clinical effects in terms of the underlying IgE-mediated reactions to innocuous environmental antigens, the low biodiversity of antigens in the domestic environment plays a pivotal role. The skewing of antigen exposure as a cumulative effect of reducing biodiversity in the immediate human environment as well as in changing food habits, provides a sufficient and parsimonious explanation for the rise in allergic diseases in a highly developed and helminth-free modernized culture. Socio-economic tendencies that incline towards a further reduction of environmental biodiversity may provide serious concern for future health. This article explains that the “Hygiene Hypothesis”, the “Old Friends Hypothesis”, and the “Skewed Antigen Exposure Hypothesis” are required to more fully explain the rise of allergy in modern societies. (shrink)

Zuerst im 2CV, dann im umgebauten VW-Bus: Das Zürcher Fotografenpaar Margrit und Ernst Baumann, 1929 bzw. 1928 geboren, begann in den 1950er-Jahren rund um den Erdball zu reisen. Ihre Fotografien publizierten sie in Zeitschriften und Zeitungen wie Stern, Neue Zürcher Zeitung oder Das gelbe Heft und brachten so die Welt in die Wohnzimmer. Kosmopolitan und neugierig kamen sie zu Motiven mit Seltenheitswert: Farbporträts von Che Guevara gehören ebenso dazu wie Reportagen über die letzten Kopfjäger im ecuadorianischen Urwald. Ein Schwerpunkt dieser (...) reich bebilderten Doppelmonografie ist ihre Reise entlang der “Panamericana” 1957-1959, die Süd- und Nordamerika verbindet. Sie fotografierten Reportagen, Porträts und Landschaftsbilder und drehten den wohl ersten Farbfilm über den legendären Verkehrsweg. Dieser Film und ein Filporträt über die beiden Fotografen sind dem Buch auf DVD beigefügt. Das Buch präsentiert Funde aus ihrem Fotoarchiv - viele Bilder erstmals im Originalausschnitt - sowie Publikationen in Zeitschriften. Der Historiker und Schriftsteller Wilfried Meichtry erzählt vom ereignisreichen Leben des Paars, das sich zeitlebens als journalistische Handwerker verstanden hat. Der Fotohistoriker Markus Schürpf ordnet ihr Werk in die Foto- und Pressegeschichte ein, Nadine Olonetzky verfasst Begleittexte zu den Bildern. Eine Entdeckung in der Schweizer Fotogeschichte. (shrink)

English summary: Does pastoral care require ethical competence in order to fulfil its task properly? And, conversely, to what extent does ethical reflection require feedback from pastoral experience in order to remain true to life and of practical relevance? Wilfried Sturm examines the way hospital pastors deal with ethical challenges and conflict situations in neonatal clinics and enquires into the insights that can be gained from them for the relationship of pastoral care and ethics. German description: Braucht Seelsorge ethische (...) Kompetenz, um ihrem Auftrag gerecht zu werden? Inwiefern bedarf umgekehrt die ethische Reflexion der Ruckkopplung an seelsorgerliche Erfahrung, um lebensnah und praxisrelevant zu bleiben? Wilfried Sturm untersucht den Umgang von Klinikseelsorgerinnen und -seelsorgern mit ethischen Herausforderungen und Konfliktsituationen in der Fruh- und Neugeborenenmedizin und fragt, welche Einsichten sich daraus fur das Verhaltnis von Seelsorge und Ethik gewinnen lassen. (shrink)

Dedekind’s structuralism is a crucial source for the structuralism of mathematical practice—with its focus on abstract concepts like groups and fields. It plays an equally central role for the structuralism of philosophical analysis—with its focus on particular mathematical objects like natural and real numbers. Tensions between these structuralisms are palpable in Dedekind’s work, but are resolved in his essay Was sind und was sollen die Zahlen? In a radical shift, Dedekind extends his mathematical approach to “the” natural numbers. He creates (...) the abstract concept of a simply infinite system, proves the existence of a “model”, insists on the stepwise derivation of theorems, and defines structure-preserving mappings between different systems that fall under the abstract concept. Crucial parts of these considerations were added, however, only to the penultimate manuscript, for example, the very concept of a simply infinite system. The methodological consequences of this radical shift are elucidated by an analysis of Dedekind’s metamathematics. Our analysis provides a deeper understanding of the essay and, in addition, illuminates its impact on the evolution of the axiomatic method and of “semantics” before Tarski. This understanding allows us to make connections to contemporary issues in the philosophy of mathematics and science. (shrink)

"Presents, and in part develops, a systematic philosophy as the universal science, or the theorization of the unrestricted universe of discourse, explicitly including being as such and as a whole. Argues that complete exploration of the theoretical domain requires such a science"--Provided by publisher.

This paper explores the interplay between logic-sensitivity and bitstring semantics in the square of opposition. Bitstring semantics is a combinatorial technique for representing the formulas that appear in a logical diagram, while logic-sensitivity entails that such a diagram may depend, not only on the formulas involved, but also on the logic with respect to which they are interpreted. These two topics have already been studied extensively in logical geometry, and are thus well-understood by themselves. However, the precise details of their (...) interplay turn out to be far more complicated. In particular, the paper describes an elegant and natural interaction between bitstrings and logic-sensitivity, which makes perfect sense when bitstrings are viewed as purely combinatorial entities. However, when we view bitstrings as semantically meaningful entities (which is actually the standard perspective, cf. the term ‘bitstring semantics’!), this interaction does not seem to have a full and equally natural counterpart. The paper describes some attempts to address this situation, but all of them are ultimately found wanting. For now, it thus remains an open problem to capture this interaction between bitstrings and logic-sensitivity from a semantic (rather than merely a combinatorial) perspective. (shrink)

The concept of merit good is a problematic concept in economic theory. The concept was introduced in 1956 by Richard Musgrave. In 1990, on the occasion of an international conference on the concept of merit good, John Head wrote that the concept of merit good raises methodologically difficult and controversial issues. The concept raises doubt about the ultimate normative authority of the consumer sovereignty principle. I will demonstrate that the concept deserves the attention of the philosophical profession for multiple reasons.

The Belgian polyarchy has developed into a «particracy» in which the political parties have a preponderant impact on the political decisionmaking.As in every polyarchy, the political parties fulfill a set of vital functions in the Belgian system. But that does not explain its «particratie» particularity. The particracy arises as a consequence of four factors. The parties are fixed by the «zuilen» into an «internal-imperialistic» role. The power of the parties increased considerably, an increase of which the politization of the instruments (...) for, and the agencies of, policy is one of the most important, together with the capability of making and unmaking issues. The impact and power of the opponents of the parties in the decision-making process have been diminished to a considerable extent. This weakening involves the king, the parliament, theadministration, the electorate, and, ultimately, the cabinet because of the growing impact of the parties on policy design and policy output as well as on the appointment of ministers. Finally, the choice of the consociational pattern of politics of accomodation by the elite indicates the instrumental function of particracy in Belgian politics. (shrink)

We still lack an operational theory for a complete analysis of early socialization processes. Bourdieu has stressed their bodily dimension but has done so at the expense of more symbolic aspects. This theoretical option corresponds to a very general goal of the Bourdieusian theory of practice: analysing sociality without suffering an intellectualist bias. However, symbolic activity and socializing language in particular can be approached as a practical phenomenon (i.e. habitual, informal, unconscious, etc.). From this viewpoint, the sociology of embodiment may (...) have much to learn from cultural psychology, which has focused on early language as it is naturally performed – when people speak to children, and when children speak. The work of cultural psychologists on the role of everyday words and narratives in the making of the self can be extended through a sociological ethnography of language. The features and interests of such an ethnography are discussed in the final section of the article, on the basis of fieldwork conducted in a nursery. This final development illustrates and analyses the concrete appropriation of caregiver injunctions by 2- to 3-year-old children. (shrink)