Der Streit darüber, ob es objektive Wahrheitskriterien gibt, wird oft mit der Frage vermengt, ob Wissenschaft immer fortschreite. Vor allem Popper in "Objective Knowledge" unterstellt in starkem Maße einen allgemeinen Trend der Wissenschaft zum Fortschritt. In diesem Beitrag wird gezeigt, daß Wissen verloren gehen kann: 1. Weil es nicht aufgezeichnet wird; 2. weil die Dokumente, in denen es niedergelegt wurde, verloren gehen; 3. weil das Wissen um die Sprache der Dokumente, in denen es niedergelegt wurde, verloren gegangen (...) ist, 4. weil die spätere Wissenschaftlergemeinschaft die Dokumente nicht genügend beachtet, in denen es niedergelegt wurde. Der Verlust nichtaufgezeichneten Wissens ist äußerst üblich. Der Verlust veröffentlichter Dokumente war besonders vor der Erfindung der Drucktechnik häufig und hat besonders in manchen Zweigen der Geisteswissenschaften einen Rückschritt bedeutet, weil entweder Dokumente, die das Objekt dieser Wissenschaften ausmachen, oder Aufzeichnungen historischer Ereignisse verloren gingen. Der Verlust veröffentlichter Dokumente nach der Erfindung der Drucktechnik war etwas weniger bedeutend, aber er kam dennoch vor. Der Verlust unveröffentlichter Dokumente geschah häufig, und zwar sowohl vor wie nach der Erfindung der Drucktechnik. Ob in unentzifferten Dokumenten definitiv Wissensverlust vorliegt, ist einigermaßen zweifelhaft. Einige unentzifferte Sprachen mögen eines Tages entziffert werden, aber einige unentzifferte Sprachen mögen auch für immer unentziffert bleiben. Der Verlust von Wissen wegen unzureichender Aufmerksamkeit gegenüber dem Werk eines früheren Wissenschaftlers kann behoben werden, wenn man seine Behauptungen nochmals untersucht. Wissensverlust kommt hauptsächlich in den Geisteswissenschaften vor. In der Mathematik und einigen Naturwissenschaften gibt es fast nur Zunahme an Wissen wegen der Wiederholbarkeit der Experimente. (shrink)

Summary This article compares the discoveries of the planets Neptune and Pluto and the unsuccessful search of intra-Mercurial planets. Its conclusion is, that the search of intra-Mercurial planets was started on the basis of reasonable assumptions and competently pursued, that the success in the search of Neptune and Pluto and the failure in the search of intra-Mercurial planets was not due to greater competence of the successful planet searchers, but to good luck of the successful researchers and bad luck of (...) the unsuccessful researchers. (shrink)

Name der Zeitschrift: Zeitschrift für Religionswissenschaft Jahrgang: 21 Heft: 2 Seiten: i-ii.

Der Beweis des Vierfarbensatzes mit Hilfe eines Computers, der so viel Zeit erforderte, daß ein Mensch die Berechnungen niemals überprüfen könnte, hat Zweifel erregt an vier philosophischen Annahmen über Mathematik. Die Mathematik ist die Lehre der Klassifikation, insoweit als sie vollständig abstrahiert von der Art der zu klassifizierenden Dinge. Diese Auffassung wird vom Beweis des Vierfarbensatzes nicht erschüttert. Wahrscheinlich kann mathematisches Denken nicht vor sich gehen ohne sinnliche Vorstellungen, aber die Eigenschaften mathematischer Gegenstände sind unabhängig von ihrer Weise sinnlicher Vorstellung.

Es wird die Frage untersucht, ob die Annahme der Existenz von universellen Normen für die Annäherung der Wissenschaft an die Wahrheit nicht in praxi lediglich Gegenwartszentrismus und Ethnozentrismus heißt. Die griechisch-römische Zivilisation förderte die Wissenschaft durch ihre Demokratie, aber andere Zivilisationen haben sehr wertvolle Datensammlungen geliefert. Die Universalität der Wissenschaft impliziert u. a. daß, wo verschiedene Zivilisationen mit ihren Wissenschaften einander begegnen, sie von einander lernen können.

Grenzen van dialoog -/- De universalismegedachte van de Verlichting heeft een -postmodernistische maatschappij van slachtoffers geschapen. Het geloofsverlies in de grote verhalen en de universalisering van het individu zorgen ervoor, dat zijn schreeuw naar verontwaardiging geen toehoorders meer vindt. Zijn roep in de woestijn gaat verloren in het chaotisch geschreeuw van de anderen. Tegenover dit koude, steriele postmodernisme stellen wij het eco-communautarisme. Vanuit de vaststelling dat het individu denkt, spreekt en handelt in de context van zijn taal en cultuur, (...) dus vanuit zijn gemeenschap, voegen wij aan Kants transcendentale ideeën 'Ik', 'Wereld' en 'God', een vierde idee toe: het 'Wij' of het principe van inclusiviteit. De Kantiaanse burgermoraal is Copernicaans geïnspireerd en steunt op de Newtoniaanse ruimte-tijdstructuur. Door middel van Hackings sociaal constructivisme, het Leibniziaanse meer-werelden-beeld en het biologische paradigma als nieuw denkkader, structureren wij de -gemeenschap volgens een cyclisch en een lineair tijdsverloop. Het cyclische waarborgt de traditie van een gemeenschap, het lineaire doet de gemeenschap evolueren naar een moreel betere toekomst. Het eco-communautarisme biedt het kader voor een kwalitatieve evolutie van individuen en gemeenschappen. Het normerend aspect hiervan is de pluriforme en multi-culturele dialoog. Een dialoog met grenzen. (shrink)

Cancers often express hundreds of genes otherwise specific to germ cells, the germline/cancer (GC) genes. Here, we present and discuss the hypothesis that activation of a “germline program” promotes cancer cell malignancy. We do so by proposing four hallmark processes of the germline: meiosis, epigenetic plasticity, migration, and metabolic plasticity. Together, these hallmarks enable replicative immortality of germ cells as well as cancer cells. Especially meiotic genes are frequently expressed in cancer, implying that genes unique to meiosis may play a (...) role in oncogenesis. Because GC genes are not expressed in healthy somatic tissues, they form an appealing source of specific treatment targets with limited side effects besides infertility. Although it is still unclear why germ cell specific genes are so abundantly expressed in cancer, from our hypothesis it follows that the germline's reproductive program is intrinsic to cancer development. (shrink)

Until late in the nineteenth century, madder was the most popular natural red dye. Holland was the largest and best-known supplier. As early as the fourteenth and fifteenth centuries, the province of Zeeland and adjoining parts of the provinces of South Holland and Brabant developed into important producers. In the course of the seventeenth century these areas even succeeded in acquiring a monopoly position. Early in the nineteenth century, however, this position came under attack because France had gone over to (...) industrial production methods from around 1800, whereas Holland continued to produce with craft technologies. After 1820, as a result, a period of stagnation and decay set in. The fate of the Dutch madder industry would have been completely sealed if the production capacity of the French factories had been sufficiently large to satisfy the great increase in demand. Consequently, in Holland, after 1845, a process of revival based upon the French manufacturing methods began slowly and hesitatingly. This process started too late and was not persevered with sufficiently to regain lost markets. The Dutch producers remained strongly attached to their own out-dated, craft methods of production. (shrink)

In addition to its well‐known role as a coenzyme in oxidation–reduction reactions, the distinct role of NAD as a precursor for molecules involved in cell regulation has been clearly established. The involvement of NAD in these regulatory processes is based on its ability to function as a donor of ADP‐ribose; NAD synthesis is therefore required to avoid depletion of the intracellular pool. The rising interest in the biosynthetic routes leading to NAD formation and the highly conserved nature of the enzymes (...) involved prompted us to reconstruct the NAD biosynthetic routes operating in distinct eukaryotic organisms. The evidence obtained from biochemical and computational analysis provides a good example of how complex metabolic pathways may evolve. In particular, it is proposed that the development of several NAD biosynthetic routes during evolution has led to partial functional redundancy, allowing a given pathway to freely acquire novel functions unrelated to NAD biosynthesis. BioEssays 25:683–690, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Prior knowledge structures (or schemas) confer multiple behavioral benefits. First, when we encounter information that fits with prior knowledge structures, this information is generally better learned and remembered. Second, prior knowledge can support prospective planning. In humans, memory enhancements related to prior knowledge have been suggested to be supported, in part, by computations in prefrontal and medial temporal lobe cortex. Moreover, animal studies further implicate a role for the hippocampus in schema-based facilitation and in the emergence of prospective planning signals (...) following new learning. To date, convergence across the schema-enhanced learning and memory literature may be constrained by the predominant use of hippocampally dependent spatial navigation paradigms in rodents, and non-spatial list-based learning paradigms in humans. Here, we targeted this missing link by examining the effects of prior knowledge on human navigational learning in a hippocampally dependent virtual navigation paradigm that closely relates to foundational studies in rodents. Outside the scanner, participants overlearned Old Paired Associates (OPA – item-location associations) in multiple spatial environments, and they subsequently learned New Paired Associates (NPA – new item-location associations) in the environments while undergoing fMRI. We hypothesized that greater OPA knowledge precision would positively affect NPA learning, and that the hippocampus would be instrumental in translating this new learning into prospective planning of navigational paths to NPA locations. Behavioral results revealed that OPA knowledge predicted one-shot learning of NPA locations, and neural results indicated that one-shot learning was predicted by the rapid emergence of performance-predictive prospective planning signals in hippocampus. Prospective memory relationships were not significant in parahippocampal cortex and were marginally dissociable from the primary hippocampal effect. Collectively, these results extend understanding of how schemas impact learning and performance, showing that the precision of prior spatial knowledge is important for future learning in humans, and that the hippocampus is involved in translating this knowledge into new goal-directed behaviors. (shrink)

Filosofische analyse van de verhouding tussen lichaam en geest en overzicht van eerdere opvattingen.

Parameters of a Bertalanffy type of temperature dependent growth model are fitted using data from a population of stone loach ( Barbatula barbatula ). Over two periods respectively in 1990 and 2010 length data of this population has been collected at a lowland stream in the central part of the Netherlands. The estimation of the maximum length of a fully grown individual is given special attention because it is in fact found as the result of an extrapolation over a large (...) interval of the entire lifetime. It is concluded that this parameter should not at forehand be set at one fixed value for the population at that location due to varying conditions over the years. (shrink)

Patient-reported outcomes are frequently used for medical decision making, at the levels of both individual patient care and healthcare policy. Evidence increasingly shows that PROs may be influenced by patients’ response shifts and dispositions. We identify how response shifts and dispositions may influence medical decisions on both the levels of individual patient care and health policy. We provide examples of these influences and analyse the consequences from the perspectives of ethical principles and theories of just distribution. If influences of response (...) shift and disposition on PROs and consequently medical decision making are not considered, patients may not receive optimal treatment and health insurance packages may include treatments that are not the most effective or cost-effective. We call on healthcare practitioners, researchers, policy makers, health insurers, and other stakeholders to critically reflect on why and how such patient reports are used. (shrink)