Despite its widespread existence, the adaptive role of aneuploidy (the abnormal state of having an unequal number of different chromosomes) has been a subject of debate. Cellular aneuploidy has been associated with enhanced resistance to stress, whereas on the organismal level it is detrimental to multicellular species. Certain aneuploid karyotypes are deleterious for specific environments, but karyotype diversity in a population potentiates adaptive evolution. To reconcile these paradoxical observations, this review distinguishes the role of aneuploidy in cellular versus organismal evolution. (...) Further, it proposes a population genetics perspective to examine the behavior of aneuploidy on a populational versus individual level. By altering the copy number of a significant portion of the genome, aneuploidy introduces large phenotypic leaps that enable small cell populations to explore a wide phenotypic landscape, from which adaptive traits can be selected. The production of chromosome number variation can be further increased by stress‐ or mutation‐induced chromosomal instability, fueling rapid cellular adaptation. (shrink)

Proceeding from Lessing’s distinction between poetry and visual art, Boris Groys argues that language is not external to, but resides behind, the image. The image constitutes the scene of a frustrated linguistic desire. Modern visual art sought to avoid the obscenity of staging this unfulfilled desire by conducting a systematic ascetic repression of the linguistic impulse. This negation of linguistic desire culminated in Judd’s ‘specific ob jects’. Y et the modern image, Groys emphasizes with reference to Greenberg and McLuhan, (...) still transmits a message, namely that of its medium bearer. Modern artists torture the image and put it into a state of emergency or exception in which it confesses its interior. In the image’s sub-medium space, in turn, resides language. Avantgarde artists and modern media theorists share the wish to achieve durability by becoming the media of the media. The border between the image and language, Groys closes, can neither be stabilized nor abolished. (shrink)

En el siguiente artículo se formulan algunas indagaciones en torno a la noción de vida contemplativa como filosofía de la inactividad dentro del pensamiento de Byung-Chul Han, tomando como referencia a Tomás de Aquino, con el objetivo de destacar la vigencia del pensamiento tomista y valorar su innegable influencia en la historia de la filosofía. Asimismo, se busca proponer cómo la vida contemplativa es el fin de la vida humana, logrando integrar, además, un vínculo con el reposo festivo, que es (...) propio de la religión. En virtud de lo mencionado, este artículo se divide en dos apartados: primero, se describe una consideración general acerca de la noción de vida contemplativa desde la visión tomista. Segundo, se muestra la interpretación que realiza Byung-Chul Han de la noción de vida contemplativa de Tomás de Aquino como parte de su fundamento filosófico de la inactividad. (shrink)

La nature des relations que l'Homme entretien avec l'Animal obéit à une loi inexorable : nul ne saurait aborder le monde des animaux sans y projeter son propre univers mental, soucieux par-là, de marquer strictement la frontière entre humanité et animalité. Comment représenter le monde dans lequel vivent les animaux, quand il nous est très largement inconnu? Pour en rendre compte, nous l'avons cerné en multipliant les approches et en mettant à profit toutes les compétences. Le vétérinaire, le mathématicien, le (...) neurobiologiste, le psychanalyste, l'éthologue, l'historien, l'archéologue, l'anthropologue, le philosophe et le psychiatre apportent chacun leur contribution à l'édifice. Le choix des auteurs et l'organisation des textes répondent à cette volonté d'interdisciplinarité, soit par des contributions originales qui donnent le dernier état du savoir, soit par des extraits empruntés à de multiples sources d'Aristote à Zola, de Darwin à Lévi-Strauss, de Freud à Jean-Paul II, de Genet à Yourcenar... (shrink)

En el siguiente ensayo se realiza un análisis crítico del tecnicismo cientificista surgido en la modernidad, a través del pensamiento existencialista de William Barrett, quien se destaca por ser uno de los principales promotores del existencialismo en Norteamérica. Con esto, Barrett pretendía contrarrestar el auge del saber tecnocientífico que se encontraba influenciando de manera negativa en la filosofía norteamericana y, además, en la religión; provocando un tránsito de la fe religiosa a la fe centrada en la técnica-tecnología, lo que ocasiona (...) el ‘sentimiento de desamparo’ en el sujeto. De esta manera, Barrett presenta al existencialismo como la mejor opción para remediar la crisis ético-antropológica que el hombre moderno se encontraba padeciendo, ya que le permite recuperar el sentido de lo humano y concientizar a la prominente masa de individuos para que puedan descubrir su verdadero destino histórico. (shrink)

Ces dernières années, des musées d’art contemporain sont apparus partout dans le monde occidental et au-delà. Le nombre de ce genre de musées augmente en permanence. Le touriste d’aujourd’hui, qui se rend dans une grande ville, s’attend à y trouver un musée d’art contemporain, de la même manière qu’il s’attend à y trouver un restaurant italien ou un cinéma. Dans la plupart des cas, ces attentes sont confirmées. Dans le pire des cas, le touriste va apprendre que le musée d’art (...) contemporain est encore en construction et qu’il sera ouvert l’année suivante. Quoi qu’il en soit, cette acceptation si facile de la notion de « musée d’art contemporain » par la culture d’aujourd’hui n’est pas sans importance. Traditionnellement, le musée d’art constituait un endroit dans lequel l’art du passé était collecté, conservé et montré au beau milieu de la vie contemporaine. Mais que signifie construire un musée d’art contemporain ? Que signifie « muséographier » la contemporanéité elle-même?Museums of contemporary art have appeared everywhere in the Western world and beyond in recent years, and they are constantly increasing in number. Any tourist visiting a major city today expects to find a museum of contemporary art, just as they expect to find an Italian restaurant or a cinema. In most cases, this is indeed what they find. At the very least, tourists will find that the city’s museum of contemporary art is still under construction and will open the following year. Whatever the case, the ready acceptance of the “museum of contemporary art” in today’s culture is significant. Traditionally, an art museum was a place where the art of the past could be collected, curated and displayed right in the heart of the contemporary world. But what does creating a museum of contemporary art really mean? In other words, what does it mean “to make a museum exhibit” of contemporaneity itself? (shrink)

El autor nos expone la influencia de la cultura Hispano-árabe en la cultura Latinoamericana, y se propone describir esta influencia desde el punto de vista del lenguaje, y el desarrollo de las humanidades, artes y ciencias. Su planteamiento es que los ochocientos años de invasión árabe en España y los cuatrocientos años de invasión española en América constituyeron los elementos a través de los cuales un cuasi-global fenómeno de transculturización tuvo lugar.

Este ensayo intenta mostrar las posibilidades analíticas del concepto de pausa sugerido por Estanislao Zuleta, a partir de su lectura del capítulo 1 de El Capital de Marx. Enlazándolo con desarrollos recientes de Kojin Karatani y Slavoj Zizek, muestra que el concepto de pausa –equivalente al de brecha o salto mortal de los dos últimos– introduce la emergencia de muchos mundos posibles en la metamorfosis de las mercancías en dinero, estableciendo la posibilidad permanente de la crisis. En consecuencia, ni las (...) crisis conducen a la revolución política, ni ésta puede detener la reproducción del capital: la revolución es una tarea de todos los días. (shrink)

This chapter argues that the distinction between ambitious and modest transcendental arguments, developed and deployed by various authors in the wake of Stroud’s influential critique of transcendental reasoning, may be pointless when applied to transcendental arguments from performative inconsistency that have moral statements as their conclusions. If moral truth is assertorically constrained, then any modest moral transcendental argument from performative inconsistency can be converted into an ambitious moral transcendental argument. The chapter provides an account of performative inconsistency and suggests an (...) alternative to the widespread reading of transcendental conditionals in terms of an ‘if-then’-sentences whose antecedents express a proposition to the effect that some x is possible and whose consequents express a statement to the effect that some y is actual. (shrink)

El presente artículo realiza un análisis filosófico de la concepción del cuerpo humano, entendido como mercancía pornográfica en La sociedad de la transparencia de Byung-Chul Han, quien advierte cómo la intimidad ha sido afectada debido a la fetichización de la sobreexposición, lo que se evidencia principalmente en la desnudez del cuerpo como efecto de la influencia de lo pornográfico. De ahí que, como objetivo general, se expondrá el proceso de profanación estético-antropológico que ha sufrido el cuerpo humano en la tardomodernidad, (...) impulsado por el sistema capitalista al convertirlo en una mercancía de consumo y que además, lo exhibe para efectuar el ideal neoliberal de la transparencia. Asimismo, lo pornográfico se equipara al Dataísmo, puesto que fragmenta la identidad del sujeto por medio del régimen de la digitalización, lo que acrecienta la crisis de lo humano. (shrink)

La 4ème de couv. indique : "Le pragmatisme, davantage qu'un véritable courant philosophique, est une attitude intellectuelle, un état d'esprit, une approche critique du contenu et des modes de production des connaissances. Il invite à se concentrer sur les actions plutôt que sur les idées, sur les pratiques plutôt que sur les pensées, sur l'expérience, sur l'utilité, sur les conséquences. Or il semble prospérer désormais jusque dans le monde des sciences du droit. Le pragmatisme juridique, attaché à l'effectivité des normes, (...) permettrait mieux que le positivisme juridique moderne, attaché à la validité des normes, d'accepter et d'expliquer les modes de régulation originaux qui émergent au XXIe siècle. L'enjeu, en se détachant de toute forme de dogmatisme, est de permettre au droit scientifique d'accompagner le droit pratique même lorsque ce dernier évolue de plus en plus profondément et de plus en plus fréquemment. C'est pourquoi un nombre croissant de juristes s'intéressent au droit vivant, au droit en action ou au droit en situation et procèdent à des expérimentations, des enquêtes ou des études de cas. Si toutes les branches du droit et toutes les branches de la recherche juridique peuvent être concernées, cela se traduit en particulier dans les travaux relatifs à la gouvernance du cyberespace, à la protection de l'environnement, à la responsabilité sociale des entreprises, à la régulation de la finance ou à l'élaboration des standards techniques. Autant de domaines particulièrement affectés par la mondialisation qui incitent les chercheurs à adopter une approche dynamique et ouverte du droit, par exemple afin d'étudier ses sources réelles plus que ses sources officielles. Tout d'abord, ce livre présente les réponses novatrices que certains scientifiques du droit contemporains apportent aux questions "quel est l'objet de la connaissance juridique et comment l'atteindre?", ces réponses étant souvent empreintes d'un pragmatisme inconscient. Ensuite, il précise et approfondit les pistes ainsi ouvertes en appliquant au droit les propositions des philosophes pragmatistes. L'ambition de cet ouvrage est donc d'affiner le visage du pragmatisme juridique en identifiant les nouvelles orientations théoriques, les nouveaux cadres épistémologiques et les nouveaux outils scientifiques s'y rapportant. Ceux-ci sont peut-être l'avenir de la recherche en droit.". (shrink)

The topics addressed in this work deal with the bioethical and legal conflicts in scenarios such as the termination of pregnancy, assisted reproductive technologies, technical developments in the genomic era, the reproductive cloning of human beings, divergences of sexual development and transsexualism, and a proposal for the analysis of ethical conflics in clinical practice. The joint work of students and professors has lead to identifying a set of issues that address both medical elements and cultural, moral, and legal variables in (...) relation to the proposed topics, in order to offer the necessary elements to deal with the complexity of each of these issues, in which cinema has been used as a didactic and mimetic resource that organizes the argumentative process of each case."--page 2 of cover. (shrink)

Resumert Este trabajo presenta varios modelos que destacan el contraste entre las teorias de la decision y de los juegos, por una parte, y la intuicidn y los datos empiricos y experimentales, por otra. Estos ejemplos estimulan la adopcion del punto de vista de la ra-.

La distopía o utopía negativa es un subgénero que ha hecho famoso la literatura inglesa, particularmente desde las obras de George Orwell (1984, de 1948) y Aldous Huxley (Brave New World, de 1932). Sin embargo, suele pasarse por alto que la primera antiutopía moderna pertenece a un autor ruso, Evgueni Zamiátin: la novela Nosotros (My), de 1922, producto de una modernidad tardía. Esta obra estableció los paradigmas que caracterizarían de ahí en más formalmente a la distopía. En 1968, los hermanos (...) Arcadi y Boris Strugatsky, principales referentes de la ciencia ficción soviética en aquellos años, reelaboraron a partir de estas bases una ciudad ya no distópica sino infernal y oscuramente irracional, eje de su novela Ciudad maldita (Grab obrechonni), una distopía ya en clave posmoderna, llevándola a un auténtico (e irresuelto) planteo sobre la naturaleza del mal. A partir de un marco teórico que vincula la evolución de las utopías negativas con la ciencia ficción, nuestra hipótesis implica que esta novela, curiosa síntesis de ciencia, política, esoterismo y literatura, define un nuevo tipo de obra distópica. El paisaje de ruinas que implica, tan caro a la ciencia ficción posterior a la caída del Muro de Berlín, se vuelve un sistema de sinécdoques que representa, desde la estética del fragmento, un profundo nihilismo donde la posmodernidad adquiere la forma de abismo. (shrink)

El pensamiento de Groys permite abordar la crítica del neoliberalismo desde una perspectiva ajena a la cuestión moderna del sujeto. El filósofo propone como alternativa a la subjetividad neoliberal: la concepción del individuo como una desfuncionalizada obra de arte. Esta alternativa se completa con la recuperación de la principal propuesta del pensamiento cosmista: la transformación de la tecnología museística en biopolítica, para que el individuo de nuestro tiempo sea objeto de permanentes cuidados. Finalmente, se analizan la potencia y límites de (...) la «museificación» para pensar en una eficaz alternativa democrática al neoliberalismo. (shrink)

There have been two major lines of research aimed at capturing resource-bounded players in game theory. The first, initiated by Rubinstein (), charges an agent for doing costly computation; the second, initiated by Neyman (), does not charge for computation, but limits the computation that agents can do, typically by modeling agents as finite automata. We review recent work on applying both approaches in the context of decision theory. For the first approach, we take the objects of choice in (...) a decision problem to be Turing machines, and charge players for the “complexity” of the Turing machine chosen (e.g., its running time). This approach can be used to explain well-known phenomena like first-impression-matters biases (i.e., people tend to put more weight on evidence they hear early on) and belief polarization (two people with different prior beliefs, hearing the same evidence, can end up with diametrically opposed conclusions) as the outcomes of quite rational decisions. For the second approach, we model people as finite automata, and provide a simple algorithm that, on a problem that captures a number of settings of interest, provably performs optimally as the number of states in the automaton increases. (shrink)

Neuroeconomics is examined critically using data on the response times of subjects who were asked to express their preferences in the context of the Allais Paradox. Different patterns of choice are found among the fast and slow responders. This suggests that we try to identify types of economic agents by the time they take to make their choices. Nevertheless, it is argued that it is far from clear if and how neuroeconomics will change economics.

The ability to compare possibilities and designate some as ‘better’ than others is a fundamental aspect of our use of modals and propositional attitude verbs. This article aims to support a proposal by Sloman that certain modal expressions, in particular, ought, in fact have a more pronounced comparative backbone than others . The connection between ‘ought’ and ‘better’ is supported by linguistic data and a proposal is advanced for modeling ideals in a way that makes room for non-comparative, strong, priority-type (...) necessity. (shrink)

We develop a framework for modeling choice in the presence of framing effects. An extended choice function assigns a chosen element to every pair (A, f ) where A is a set of alternatives and f is a frame. A frame includes observable information that is irrelevant in the rational assessment of the alternatives, but nonetheless affects choice. We relate the new framework to the classical model of choice correspondence. Conditions are identified under which there exists either a transitive or (...) a transitive and complete binary relation R such that an alternative x is chosen in some (A, f ) iff x is R-maximal in the set A. We then demonstrate that the framework of choice correspondence misses information, which is essential to economic modeling and which is incorporated in the extended choice function. (shrink)

The standard economic choice model assumes that the decision maker chooses from sets of alternatives. In contrast, we analyze a choice model in which the decision maker encounters the alternatives in the form of a list. We present two axioms similar in nature to the classical axioms of choice from sets. We show that they characterize all the choice functions from lists that involve the choice of either the first or the last optimal alternative in the list according to some (...) preference relation. We then relate choice functions from lists to the classical notions of choice correspondences and random choice functions. (shrink)

A speaker wishes to persuade a listener to accept a certain request. The conditions under which the request is justified, from the listener’s point of view, depend on the values of two aspects. The values of the aspects are known only to the speaker and the listener can check the value of at most one. A mechanism specifies a set of messages that the speaker can send and a rule that determines the listener’s response, namely, which aspect he checks and (...) whether he accepts or rejects the speaker’s request. We study mechanisms that maximize the probability that the listener accepts the request when it is justified and rejects the request when it is unjustified, given that the speaker maximizes the probability that his request is accepted. We show that a simple optimal mechanism exists and can be found by solving a linear programming problem in which the set of constraints is derived from what we call the L-principle. (shrink)

(2) Mental preferences: These describe the mental attitude of an individual toward the objects. They can be defined in contexts which do not involve actual choice. In particular, preferences can describe tastes (such as a preference for one season over another) or can refer to situations which are only hypothetical (such as the possible courses of action available to an individual were he to become Emperor of Rome) or which the individual does not fully control (such as a game situation (...) in which a player has preferences over the entire set of outcomes). (shrink)

The fourth-century B.C. was a period during which a large number of Greek cities were affected by civil wars, military conquests, and destruction, with the displacement of large numbers of men, women and children as a result. This has implications for the modern debate on Athenian attitudes to immigration, which normally focuses on just two groups of free non-citizens: adult, able-bodied men who moved to Athens voluntarily to take advantage of the city’s economic opportunities and on the free non-citizen population (...) who had come to Athens as slaves and who stayed on after their manumission. This article argues that refugees were likely to have constituted a considerable component of the migration to Athens during certain troubled periods in the course of the fourth century. This means that the size of Athens’s immigrant population was likely to have fluctuated considerably, that many of the refugees would have been destitute, that women and children may have made up an even greater proportion of the non-citizen population than normally assumed, and, thus, that a considerable number of these immigrants would not have been able to contribute substantially to Athens’s grain trade or military. The implications of this for our assessment of the Athenian motives for admitting groups of refugees are discussed, and it is argued that the requirement that all male and all unaccompanied female immigrants had to find an Athenian sponsor and pay a special metic tax may have constituted a certain level of control over immigrant numbers. (shrink)

New York University. He is the recipient of the Bruno Prize (2000), the Israel Prize (2002), the Nemmers Prize (2004).

Ludwig Wittgenstein imagines a variety of eccentric social practices—like a tribe trained “to give no expression of feeling of any kind”. But he also speaks of “the common behavior of mankind” that is rooted in “natural/primitive reactions”. This emphasis on the uniformities of human behavior raises questions about the plausibility of some of his imagined language games. Indeed, it suggests the claim of evolutionary psychologists that there are biologically based human universals that shape social practices. But in contrast to E.O. (...) Wilson's belief that “genes hold culture on a leash”, Wittgenstein sees culture as a mediator—rather than a conduit—of “natural reactions”. This suggests that social science can incorporate the claims of evolutionary psychology without scanting the centrality of culture in action and allows that nature can be overwhelmed by culture. (shrink)

The volume collects classics of Marxist historiography of science, including a new translation of Boris Hessen's “The Social and Economic Roots of Newton's ...

In this paper, the term ‘debate’ refers to a situation in which two parties disagree over some issue and each of them tries to persuade a third party, the listener, to adopt his position by raising arguments in his favor. We are interested in the logic behind the relative strength of the arguments and counterarguments; we therefore limit our discussion to debates in which one side is asked to argue first, with the other party having the right to respond before (...) the listener makes up his mind. (shrink)

The paper presents a simple game-theoretic model in which players decide on search procedures for a prize located in one of a set of labeled boxes. The prize is awarded to the player who finds it first. A player can decide on the number of (costly) search units he employs and on the order in which he conducts the search. It is shown that in equilibrium, the players employ an equal number of search units and conduct a completely random search. (...) The paper demonstrates that the search procedure is intrinsically inefficient. Journal of Economic Literature Classification.. (shrink)