Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host cells. Through in vitro SARS‐CoV‐2 infection studies and analysis of COVID‐19 patient samples, we found that SARS‐CoV‐2 suppresses the induction of the MHC class I pathway by inhibiting the expression and function of NLRC5, a major transcriptional regulator of MHC class I genes. (...) In this review, we discuss the molecular mechanisms for suppression of the MHC class I pathway and clinical implications for COVID‐19. (shrink)

Not a few feminist writers, such as Kristeva, Irigaray, and Chodorow, have dealt with Freud’s psychoanalysis so far, but it is not clear to what degree the Freudian theory grounds their arguments, because Freud himself developed his psychoanalysis mainly for the male mental world (Seelenleben). In this paper, we shall follow Freud’s train of thought exclusively from this angle. After the geneses of Pcpt.-Cs., id, ego, and super-ego (W-Bw, Es, Ich, and Über-Ich, respectively) are treated (§§7-10), we shed light on (...) how these factors relate to the female spirituality (§§11-24) and why feminists could still rely on Freud’s thought (§25). On the other hand, the present research will also provide an easy introduction to Freud’s psychoanalysis, by reference to which each thinker could overview the Freudian theory (Fig. (5) and Fig. (8) will help). In this respect, we shall also take account of the masculine side of his discussion, that is to say, how a man usually develops his male personality, while we constantly put it in stark contrast to the female spirituality. Although, in this modern world, not a few thinkers criticize the Freudian theory as non-scientific like Popper did (§2), we should remember that there remain supporters of his theory, such as Grümbaum (§3). We shall touch on this kind of argument relating to philosophy of science in the first half of this paper, which will also provide some useful knowledge for the readers who still get doubtful of the Freudian theory and its usage in feminist arguments. (shrink)

Employing conversation analysis, this article investigates instructions in lessons for guitar and Japanese calligraphy. In receiving an instruction, the students in the guitar lessons are expected to immediately follow the instruction. In contrast to the guitar lessons, the students in the calligraphy lessons are not institutionally expected to immediately follow the teacher’s instructions but to receive them. However, the students often gesticulate what they learned from and could make sense of the prior instruction upon completion of an instruction activity. I (...) call this phenomenon embodied solitary confirmation. By demonstrating the interactional procedure for this practice, this article respecifies reflection as an interactional phenomenon and elucidates an organization of multiactivity. (shrink)

Categorial grammar is well-known for its elegant analysis of coordination enabled by the flexible notion of constituency it entertains. However, to date, no systematic study exists that examines whether this analysis has any obvious empirical advantage over alternative analyses of nonconstituent coordination available in phrase structure-based theories of syntax. This paper attempts precisely such a comparison. We compare the direct constituent coordination analysis of non-canonical coordinations in categorial grammar with an ellipsis-based analysis of the same phenomena in the recent HPSG (...) literature. We provide a set of empirical evidence, consisting of cases in which non-canonical coordinations interact with scopal operators of various sorts, which systematically falsifies the predictions of the latter, ‘linearization-based’ ellipsis approach to coordination. We propose an alternative analysis in a variant of categorial grammar called Hybrid Type-Logical Categorial Grammar. The proposed framework builds on both the Lambek-inspired variants of categorial grammar and a more recent line of work modelling word order via a lambda calculus for the prosodic component. The flexible syntax–semantics interface of this framework straightforwardly captures the interactions between non-canonical coordinations and scopal expressions, demonstrating the broader empirical payoff of the direct constituent coordination analysis of non-canonical coordinations pioneered by Steedman :523–568, 1985; Linguist Philos 13:207–263, 1990) and Dowty hitherto not explicitly recognized in the literature. (shrink)

The aim of this paper is to call the attention, especially that of feminists, to the current progress in biology. It appears gender studies still confine themselves to outdated ideas of sex chromosomes like XX, XY (§10). However, science has been making progress. It no longer sticks to such matters as XX, XY. Its interest is now in Sry, a kind of gene (§11), and MIS, a kind of sex hormone (§14). Abnormalities of sex chromosomes are no longer evidence to (...) deny the biological approaches, for example. We shed light on this fact, putting gender studies in the context of chronologies of science as well (§§2-9). (shrink)

Cet article cherche à examiner la thèse fondamentale de Neue Phänomenologie in Frankreich, selon laquelle la spécificité du mouvement phénoménologique récent en France consisterait à décrire le « phénomène phénoménologique » d’une nouvelle manière et précisément selon son « événementialité ». À cette fin, il ne suffit pas simplement de reconstruire ou de résumer cette thèse telle qu’elle est exposée dans l’ouvrage, mais il est également nécessaire de construire de manière progressive le concept général d’événement et celui de « phénomène (...) phénoménologique » conçu selon son événementialité. Cette étude essaie de répondre aux trois questions suivantes : qu’est-ce que la « nouvelle phénoménologie en France » ; qu’entend-t-on couramment par « événement »? ; comment cette transformation du concept phénoménologique de phénomène motive-t-elle une réorganisation remarquable de sa méthode, à laquelle Janicaud a reproché d’être un « tournant théologique »? (shrink)

A decision tree is one of the machine learning techniques and also one of the major knowledge representations of data mining results.This is because it is easy to understand its meaning for human analysts.Even ID3, the representative algorithm, is known to exhibit remarkable performance deterioration under certain circumstances, particularly due to strong correlation between attributes representing the class of examples. One of the approaches to get more preferable decision trees is pre-processing the training data to extend its description, such as (...) attributes generation and attribute selection. There is also the idea of decision trees with a region rule. In this paper, we consider two approaches, i.e., decision trees with a region rule allowing multiple attributes, and a pre-processing method of a region rule to enabling any suitable number of attributes to correspond to branch nodes, where an optimal division condition with arbitrarily multiple attributes is acquired. By using this method, we propose a new decision tree generation algorithm guaranteeing to select effective compound attributes with each branch node, where an MDL-based new evaluation criterion is also defined for determining the optimal number of compound attributes specified to each node.This algorithm is applied to datasets containing only nominal values. It consists of three processes: compound attributes selection, parent node integration, and pruning. We call this new decision trees DTMACC (Decision Trees with Multiple Attributes Concept Clustering). The effectiveness and comprehensiveness of the proposed algorithm are confirmed through experiments comparing to the ordinary decision trees and an effective pre-processing method. (shrink)

This paper elucidates Fink’s phenomenology of the world in its basic conception by illustrating his Kant-interpretation. However, some scholars support that his conceptions are not related to Kant’s transcendental dialectic but rather generated from Hegelian speculative one. In contrast to those views in secondary literature, this study demonstrates, on the one hand, the decisive meaning of Kant’s transcendental dialectic, especially the “cosmological antinomy”, for the formation of Fink’s philosophy as a whole and, on the other hand, how Fink elucidates phenomenologically (...) the problem of the pre-givenness of the world by criticizing Kantian so called Copernican turn and transforming his architectonic of the transcendental philosophy. (shrink)

Although written in Japanese, this book becomes a landmark of my works so far: that on Zangwill (Kaneko, 2011), that on Utilitarianism (2013), and so on. The novelty shown in it is a formalization of traditional philosophy including Kant (its practical philosophy), Utilitarianism (Hume, Bentham, and Mill), and furthermore, Descartes. I try to locate these traditional thoughts within modern forms which I make in the name of "practical syllogism." This attempt would open up a new approach to ethical motivation.

LK is much more difficult than NK, and to make matters worse, Gentzen's intention is still unclear when it comes to that system (LK). -/- The second and third volumes of the series titled What is LK? conduct the detailed survey of each inference-figure in a toe-to-toe way, as it were, which most mathematicians looked through. -/- The present volume, Vol.3, looks deeper into those operational inference-figures which concerns propositional logic.

LK is much more difficult than NK, and to make matters worse, Gentzen's intention is still unclear when it comes to that system (LK). -/- After long surveys conducted from Vol.1 to Vol.4, all of which shares the common title What is LK?, this fifth volume finally handles the solved problems in the realm of propositional logic in LK.

This study aims to explicate interviewer and candidate conversational practices in L2 job interviews as they relate to the assessment of a candidate’s qualification for a particular position. The data consisted of 27 audio-recorded job interviews for the position of student assistant in English classes at a Japanese university. The analysis of these interactional data, conducted using conversational analysis methodology, revealed that the inadequacy of a candidate’s response is constructed by means of the interviewer’s subsequent pursuit of a relevant answer (...) from the candidate. In addition, a candidate’s ability to build rapport by providing sequentially linked joke-serious responses evoked a positive evaluation from the interviewer. The findings indicate that a candidate’s understanding of expected behaviors and ability to accommodate his or her behaviors in a manner relevant to the interaction result in a positive assessment. (shrink)

Real-world walking activity is important for poststroke patients because it leads to their participation in the community and physical activity. Walking activity may be related to adaptability to different surface conditions of the ground. The purpose of this study was to clarify whether walking adaptability on an uneven surface by step is related to daily walking activity in patients after stroke. We involved 14 patients who had hemiparesis after stroke and 12 healthy controls. The poststroke patients were categorized as least (...) limited community ambulators or unlimited ambulators. For the uneven surface, the study used an artificial grass surface. The subjects repeated even surface walking and the uneven surface walking trials at least two times at a comfortable speed. We collected spatiotemporal and kinematic gait parameters on both the even and uneven surfaces using a three-dimensional motion analysis system. After we measured gait, the subjects wore an accelerometer around the waist for at least 4 days. We measured the number of steps per day using the accelerometer to evaluate walking activity. Differences in gait parameters between the even and uneven surfaces were calculated to determine how the subjects adapted to an uneven surface while walking. We examined the association between the difference in parameter measurements between the two surface properties and walking activity. Walking activity significantly and positively correlated with the difference in paretic step length under the conditions of different surface properties in the poststroke patients and step width in the healthy controls. The strategy of increasing the paretic step length, but not step width, on an uneven surface may lead to a larger base of support, which maintains stability during gait on an uneven surface in poststroke patients, resulting in an increased walking activity. Therefore, in poststroke patients, an increase in paretic step length during gait on an uneven surface might be more essential for improving walking activity. (shrink)

The original interest of this article lies in existential import. It provides a broader view on the problem by reference to modern, symbolic logic (ch.1). Gradually, however, our interest will change into the amalgamated expressions often used in logic; that is, why are such expressions as “x is a round triangle” applied in logic? We critically discuss this question from an extensional viewpoint, namely model theoretic semantics (ch.2). We also touch on Church’s λ-calculus in the appendix (app.2).

Young children generally learn words from other people. Recent research has shown that children can learn new actions and skills from nonhuman agents. This study examines whether young children could learn words from a robot. Preschool children were shown a video in which either a woman or a mechanical robot labeled novel objects. Then the children were asked to select the objects according to the names used in the video. The results revealed that children in the human condition were more (...) likely to select the correct objects than those in the robot condition. Nevertheless, the five-year-old children in the robot condition performed significantly better than chance level, while the four-year olds did not. Thus there is a developmental difference in children’s potential to learn words from a robot. The results contribute to our understanding of how children interact with non-human agents. Keywords: developmental cybernetics; word learning; social cognition; cognitive development. (shrink)

This paper aims to analyze R. G. Collingwood’s maiden work in philosophy, Religion and Philosophy, in the light of the realism/idealism dispute in early twentieth-century British philosophy. Due to scholars’ narrow scopes of interests, this book has suffered divided and unsettled understandings in literature that find only either realist or idealist character in it. By contrast, I comprehensively examine various aspects of the work on which both readings rest in turn—his conception of history and metaphysics. Consequently, I find out that (...) Collingwood implicitly elaborates a series of negative doctrines attempting to overcome dualismspervading at both poles of the dispute, namely abstract/concrete, subject/object, and theory/action. Since this framework is to be more explicitly present in his subsequent philosophizing, I demonstrate that Religion and Philosophy was, against its underestimated status in literature, not mere juvenilia, but a substantialstarting-point for Collingwood’s philosophy constructively grounded in the contemporary debate. (shrink)

Although written in Japanese, an overall picture of quantum physics is drawn, which would surely be useful for beginners as well as researchers of the humanities.

Sex chromosomes in plants have been known for a century, but only recently have we begun to understand the mechanisms behind sex determination in dioecious plants. Here, we discuss evolution of sex determination, focusing on Silene latifolia, where evolution of separate sexes is consistent with the classic “two mutations” model—a loss of function male sterility mutation and a gain of function gynoecium suppression mutation, which turned an ancestral hermaphroditic population into separate males and females. Interestingly, the gynoecium suppression function in (...) S. latifolia evolved via loss of function in at least two sex‐linked genes and works via gene dosage balance between sex‐linked, and autosomal genes. This system resembles X/A‐ratio‐based sex determination systems in Drosophila and Rumex, and could represent a steppingstone in the evolution of X/A‐ratio‐based sex determination from an active Y system. (shrink)

La 4ème de couverture indique : "La consolidation de la IIIe République et de l’État Meiji s’appuie sur trois piliers : administration agricole, éducation publique et conscription universelle. À cet égard, l’analyse comparée de la construction de la morale politique française et japonaise au XIXe siècle est instructive, qui révèle une proximité. L’attachement égal du citoyen républicain et du sujet impérial à une sacralité, qu’elle fût « laïque » ou « théocratique », du régime politique le définissant, montre que la (...) légitimation du pouvoir ne représente pas seulement un degré de rationalité mais des modes d’intériorisation des normes, radicalement différents, qui hantent encore les formes les plus rigoureuses du nationalisme.". (shrink)

In spite of the evident centrality of philosophical 'realism' in Collingwood's autobiographical account of his own intellectual development, his critique of 'realism' has hardly been investigated as a central theme in his philosophy. Collingwood's arguments against contemporary 'realism' and his stated move beyond 'idealism' have mostly been treated as a minor question subordinate to other questions. By contrast, I have tried in this thesis to reconstruct Collingwood's philosophy as a critical development of the realism/idealism dispute of his day, focusing on (...) his less known early published and unpublished philosophical writings. This has enabled me to clarify his unique definition of 'realism' in terms of a dualistic framework, and understand his philosophy as an attempt to overcome such dualisms in the realms of philosophy. This approach ultimately highlighted the aim of Collingwood's reform of philosophy as the better understanding of the human mind and action. By employing the 'historical' and 'internal' method of analysis, I firstly illustrated how the idea of 'dualism' became an issue in the realism/idealism dispute as it emerged in early twentieth-century British philosophy. This was followed by a biographical sketch in which I demonstrated that Collingwood's educational background was perfectly equipped to refute the 'realist' philosophy in the dispute. Historically contextualising thus, I chronologically restored the formation of his critique of 'realism' as his attempts to synthesise dualisms in logic, ontology, epistemology, and ethics during the period between Religion and Philosophy and An Essay on Philosophical Method. Finally, I argued that Collingwood's critique of 'realism' crystallised in his notion of duty, which embodied his characterisation of philosophy as both 'normative' and 'descriptive'. Throughout, I presented a systematic and sustained picture of Collingwood's early philosophy, identifying and unfolding the fertile implications of his critique of 'realism' for his principal concern with the human mind and action. (shrink)

The vestibulo-ocular reflex plays an important role in controlling the gaze at a visual target. Although patients with vestibular hypofunction aim to improve their VOR function, some retain dysfunction for a long time. Previous studies have explored the effects of direct current stimulation on vestibular function; however, the effects of random noise stimulation on eye–head coordination have not previously been tested. Therefore, we aimed to clarify the effects of high frequency noisy vestibular stimulation on eye–head coordination related to VOR function. (...) Thirteen healthy young adult participants with no serious disease took part in our study. The current amplitude and density used were 0.4 mA and 0.2 mA/cm2, respectively, with a random noise frequency of 100–640 Hz. The electrodes were located on both mastoid processes. The stimulus duration and fade in/out duration were 600 and 10 s, respectively. Subjects oscillated their head horizontally, gazing at the fixation point, at 1 Hz for 30 repetitions. The coordination of eye–head movements was measured by eye-tracking and a motion capture system. Peak-to-peak angles for eye and head movement and deviation of the visual line from the fixation target revealed no significant differences between HF-nVS and sham. The lag time between the eye and head movement with HF-nVS post-stimulation was significantly shorter than that of the sham. We found that HF-nVS can reduce the lag time between eye and head movement and improve coordination, contributing to a clear retinal image. This technique could be applied as a form of VOR training for patients with vestibular hypofunction. (shrink)

The aim of this paper is to apply inductive logic to the field that, presumably, Carnap never expected: legal causation. Legal causation is expressible in the form of singular causal statements; but it is distinguished from the customary concept of scientific causation, because it is subjective. We try to express this subjectivity within the system of inductive logic. Further, by semantic complement, we compensate a defect found in our application, to be concrete, the impossibility of two-place predicates (for causal relationship) (...) in inductive logic. (shrink)

The Internet was born in 1960’s, then Internet ethics appeared as a branch of information ethics. It seems, however, our status on the Net is not yet scrutinized. We investigate this problem with the help of philosophers like Dreyfus, Merleau-Ponty, and Austin.

Although we often see references to Carnap’s inductive logic even in modern literatures, seemingly its confusing style has long obstructed its correct understanding. So instead of Carnap, in this paper, I devote myself to its necessary and sufficient commentary. In the beginning part (Sections 2-5), I explain why Carnap began the study of inductive logic and how he related it with our thought on probability (Sections 2-4). Therein, I trace Carnap’s thought back to Wittgenstein’s Tractatus as well (Section 5). In (...) the succeeding sections, I attempt the simplest exhibition of Carnap’s earlier system, where his original thought was thoroughly provided. For this purpose, minor concepts to which researchers have not paid attention are highlighted, for example, m-function (Section 8), in-correlation (Section 10), C-correlate (Section 10), statistical distribution (Section 12), and fitting sequence (Section 17). The climax of this paper is the proof of theorem (56). Through this theorem, we will be able to overview Carnap’s whole system. (shrink)

Although written in Japanese, 意志の解明（Explication of Will） pursues a Davidson-style logical formula of will-stating sentences.

Hans Jonas and Arne Næss have argued that philosophers need not be concerned with natural sciences even when they talk about enviromental issues like global warming (§1). However, believing sciences blindly is in itself unphilosophical. So we think, in this paper, the other way around: We consider the current view of global warming, which was reported by the IPCC, critically. The so-called AR4 is divided into two parts. One is about the industrial revolutions (§§5-9); the other is about the greenhouse (...) effect (§§11-20). Through this consideration, it will be revealed: the views of the Establishment are not at all absolute; there still remains room to reconsider them. (shrink)

The concept and the logic of the political, the most notable Schmittian ideas, based on the friend/enemy distinction and his thought on political theology have been widely and critically discussed and actively appropriated with various interpretations. On the other hand, we find that there is certain definite momentum piercing through the theoretical structure of Husserl’s phenomenology in general both as a form of metaphysics and as a philosophical movement, which can also be called the political. In this circumstance, we find (...) the Schmittian logic of the political together with his idea of political theology specifically serviceable for an effective visualization of the political characteristically structured in Husserl’s system, particularly in the concepts of transcendental subjectivity and universal critique. This paper argues that Husserl’s phenomenological critical subject is fundamentally a politico-theological subject and is an attempt to show to what extent and in what way Schmitt can be strategically utilized to make manifest the politicality that we discover as something that structurally inheres in Husserlian notion of subjectivity and critique. *. (shrink)

Although written in Japanese, 動機説の観点から見た倫理的判断の諸相（Phases of the ethical judgement）has formed my original ideas on action theory, ethics, and so on.

LK is much more difficult than NK, and to make matters worse, Gentzen's intention is still unclear when it comes to that system (LK). -/- The second, third, and fourth volumes of the series titled What is LK? conduct the detailed survey of each inference-figure in a toe-to-toe way, as it were, which most mathematicians looked through. -/- The present volume, Vol.4, looks deeper into those operational inference-figures which concerns predicate logic.