Cancer cells accumulate widespread local and global chromatin changes and the source of this instability remains a key question. Here we hypothesize that chromatin alterations including unscheduled silencing can arise as a consequence of perturbed histone dynamics in response to replication stress. Chromatin organization is transiently disrupted during DNA replication and maintenance of epigenetic information thus relies on faithful restoration of chromatin on the new daughter strands. Acute replication stress challenges proper chromatin restoration by deregulating histone H3 lysine 9 mono‐methylation (...) on new histones and impairing parental histone recycling. This could facilitate stochastic epigenetic silencing by laying down repressive histone marks at sites of fork stalling. Deregulation of replication in response to oncogenes and other tumor‐promoting insults is recognized as a significant source of genome instability in cancer. We propose that replication stress not only presents a threat to genome stability, but also jeopardizes chromatin integrity and increases epigenetic plasticity during tumorigenesis. (shrink)

Recent scientific advances mean the widespread introduction of non-invasive prenatal diagnosis (NIPD) for chromosomal aneuploidies may be close at hand, raising the question of how NIPD should be introduced as part of antenatal care pathways for pregnant women. In this paper, the authors examine the ethical implications of three hypothetical models for using NIPD for aneuploidy in state-funded healthcare systems and assess which model is ethically preferable. In comparing the models, the authors consider their respective timings; how each model would (...) fit with current screening and diagnostic tests offered to pregnant women; the implications of offering NIPD at different stages of pregnancy; and the potential for each model to support reproductive autonomy and informed decision-making. The authors conclude by favouring a model that would be offered at 11–13 weeks gestation, alongside existing combined screening, provided that this is accompanied by measures to maximise informed decision-making, for example, provision of adequate pretest and post-test counselling. (shrink)

Pharmacists who refuse to provide certain services or treatment for reasons of conscience have been criticized for failing to fulfil their professional obligations. Currently, individual pharmacists in Great Britain can withhold services or treatment for moral or religious reasons, provided they refer the patient to an alternative source. The most high-profile cases have concerned the refusal to supply emergency hormonal contraception, which will serve as an example in this article.I propose that the pharmacy profession's policy on conscientious objections should be (...) altered slightly. Building on the work of Brock and Wicclair, I argue that conscientious refusals should be acceptable provided that the patient is informed of the service, the patient is redirected to an alternative source, the refusal does not cause an unreasonable burden to the patient, and the reasons for the refusal are based on the core values of the profession. Finally, I argue that a principled categorical refusal by an individual pharmacist is not morally permissible. I claim that, contrary to current practice, a pharmacist cannot legitimately claim universal exemption from providing a standard service, even if that service is available elsewhere. (shrink)

It is widely accepted in the pharmacy profession that pharmacists have the right to conscientiously refuse to participate in certain practices on grounds of conscience. This is allowed in recognition of differences in moral and religious views and out of respect for moral integrity. However, the “conscience clause” does not necessarily sit easily in a professional code of ethics owing to the potential tensions between a professional’s personal moral integrity and her professional obligations. At the heart of these tensions are (...) philosophical questions about the nature of conscience and integrity.These in turn lead to important practical ethical questions about the adequacy of a conscience clause to protect integrity and patient’s rights and guard against wrongdoing, whether conscientious refusals should be publicly announced in advance and what the acceptable bases of a conscientious refusal might be. Such questions apply not just to the professional, but also to pharmacy students, who may hold conscientious objections to some aspects of their training.It is concluded that the conventional compromise that is commonly in place in the pharmacy profession is a workable but imperfect solution and that better understanding of the concepts and competing obligations may be achieved by learning more about conscientious decision-making by pharmacists in practice. (shrink)

Propositional fuzzy logics given by a combination of a continuous SBL t-norm with finitely many idempotents and of an involutive negation are investigated. A characterization of continuous t-norms which, in combination with different involutive negations, yield either isomorphic algebras or algebras with distinct and incomparable sets of propositional tautologies is presented.

Abstract This paper aims to analyse Karl Popper's conception of ?three worlds?, and especially the problem of world 3?the world of objective knowledge. Firstly, I try to explain Popper's turn to ontological questions which I link to his antipsychologism and to issues raised by the development of logic after World War II. I then consider Popper's concept of the autonomy of world 3 and his attempt to introduce world 3 as a world of knowledge without a knowing subject. I conclude (...) that Popper did not succeed in unifying his central idea of autonomy of knowledge with the requirement of the creative role of the critical subject carrying out the evolution of knowledge. I see the core of this contradiction especially in his co?existing ideas of the timeless existence of world 3 and the elimination of the subject from it. The attempt to desubjectivize the realm of objective knowledge leads to a philosophically unbalanced standpoint which presupposes a creative subject and at the same time neglects it. Finally, I question Popper's account of the growth of world 3. Popper considers only cognitive motivations, and excludes a broad range of motivating factors which originate in the problems which we face in our lives, and affect our cognitive interests in world 3. (shrink)

Present study sheds more light on the conceptualization of citizenship and civic engagement among majority and minority youth. In order to understand the meanings of citizenship, fourteen focus groups were conducted with young people aged 16–26, with both civically engaged and disengaged young ethnic Czechs, Roma, and Ukrainians. Results suggest that young people understand the citizenship as having multiple dimensions (legal and personal, and in terms of rights and responsibilities) and civic engagement as being focused on various aspects. The way (...) people described their position within society was influenced by the social background and mirrored in the views on full citizenship. (shrink)

This paper presents the link between Arthur N. Prior and logicians that belonged to the Lvov-Warsaw School. Although certain members of the Lvov-Warsaw School influenced Prior’s views, the amount and the form of the impact are still under discussion. Prior also cooperated with some of them in the development of his systems of logic. This paper focuses on four main areas in which Prior admitted adopting ideas from the Lvov-Warsaw School: systems of propositional logic, the history of logic, modal and (...) temporal logic and ontology. Prior’s published works as well as his correspondence, which is stored in Prior’s Nachlass, are used to describe the influence. (shrink)

Empirical evidence suggests that some health professionals believe consent procedures for the emerging technology of non-invasive prenatal diagnosis (NIPD) should become less rigorous than those currently used for invasive prenatal testing. In this paper, we consider the importance of informed consent and informed choice procedures for protecting autonomy in those prenatal tests which will give rise to a definitive result. We consider whether there is anything special about NIPD that could sanction a change to consent procedures for prenatal diagnosis or (...) otherwise render informed decision-making less important. We accept the claim that the absence of risk of miscarriage to some extent lessens the gravity of the decision to test compared with invasive methods of testing. However, we also claim that the definitive nature of the information received, and the fact that the information can lead to decisions of great significance, makes NIPD an important choice. This choice should only be made by means of a rigorous and appropriately supported decision-making process (assuming that this is what the pregnant woman wants). We conclude that, on balance, consent procedures for NIPD should mirror those for invasive testing, albeit without the need to emphasise procedure-related risk. (shrink)

Non-invasive prenatal testing is an emerging form of prenatal genetic testing that provides information about the genetic constitution of a foetus without the risk of pregnancy loss as a direct result of the test procedure. As with other prenatal tests, information from NIPT can help to make a decision about termination of pregnancy, plan contingencies for birth or prepare parents to raise a child with a genetic condition. NIPT can also be used by women and couples to test purely ‘for (...) information’. Here, no particular action is envisaged following the test; it is motivated entirely by an interest in the result. The fact that NIPT can be performed without posing a risk to the pregnancy could give rise to an increase in such requests. In this paper, we examine the ethical aspects of using NIPT ‘purely for information’, including the competing interests of the prospective parents and the future child, and the acceptability of testing for ‘frivolous’ reasons. Drawing on several clinical scenarios, we claim that arguments about testing children for genetic conditions are relevant to this debate. In addition, we raise ethical concerns over the potential for objectification of the child. We conclude that, in most cases, using NIPT to test for adult-onset conditions, carrier status or non-serious traits presenting in childhood would be unacceptable. (shrink)

From the other side: On dialogue in texts by Jostein Gaarder. – By analysing the phenomenon of dialogue in the works of the Norwegian writer Jostein Gaarder the paper shows the essence of the dialogical situation of man in the world. Admittingly, people find themselves in such dialogical situation already. However, by virtue of their freedom, they are capable of going beyond the existing feeling of security, and – through fundamental dialogue with a person coming from the other side, one, (...) that is different, whose situation is different – finding a new dimension of human life, find life in truth, life of the uncovered (alétheia), in which freedom and responsibility of the dialogical being can be realised in a unique way. (shrink)

This article argues that intersectional analyses of care work also need to include a temporal aspect. Drawing on ethnographic research on Slovak au pairs working in the UK and on interviews with both providers and employers of paid childcare in Slovakia, I examine how the temporariness of care work is created within both migrant and non-migrant settings. In particular, I demonstrate that both employers and providers conceptualise paid childcare as a temporary period in their lives and show the consequences of (...) this conceptualisation in their valuing of care work. In both examined cases, I focus on the role of care/welfare and migration regimes in the production of temporariness in care work and argue that both providers and employers of paid care construct their involvement in domestic work as a specific life course experience. While for au pairs, working stays in the UK represent a specific transition period from adolescence to adulthood, employers in Slovakia decide to employ particular types of domestic workers in relation to the particular developmental phases of their families and households. (shrink)

The present study analyses education policy in Slovakia and determines the role of the church in education governance and the church–state relationship in education policy. The church–state relationship is also evident in the specific constellations of the national curriculum. The study highlights the de-secularisation trend in education policy and curricula and identifies the links between religious and nationalist education content, which are largely a relic of the historical era of Slovak statehood building. It also analyses Ethical Education, which is a (...) specific school subject in Slovakia that has been shaped by a particular church–state ‘ideological governing form’. (shrink)

Con el objetivo de identificar la percepción de la ventaja intercultural evidenciada en la narración de hechos, este estudio busca contribuir en el entendimiento de las relaciones interculturales en ámbitos familiares mixtos entre individuos de diferente nacionalidad. A través de un estudio que ha recuperado el discurso de los miembros de ocho parejas checo-mexicanas, se muestra que la ventaja percibida se desprende de la adquisición de competencias interculturales. La información recabada se ha organizado mediante la evaluación de cuatro elementos que (...) definen la interculturalidad: relaciones de poder, comunicación intercultural, integración y alteridad cultural. El principal hallazgo indica que el contexto en el cual se han conformado las parejas mixtas checo-mexicanas se caracteriza por un equilibrio en la negociación de interés para formar metas vitales conjuntas. Dicha ventaja se materializa en la ampliación de la oportunidad para moverse entre dos países, sea para establecerse en el país de encuentro, sea para migrar al país del otro. La tendencia mostrada se ha sesgado hacia el país de la mujer. (shrink)

Purpose of the article The issue of creating advertising that is culturally congruent has been considered to be very important to experts dedicated to the field in the past years. Culture is an important internal factor of customer behavior that needs to be fully considered if the advertising campaigns aim to address its target audience effectively. The goal of this article is to contribute to existing knowledge in the area of culturally congruent advertising. More specifically, to find out what advertising (...) appeals are preferred in Slovak television advertising. Methodology/methods Main scientific method of the present research was conceptual content analysis. The results are based on the sample of 133 TV commercials broadcasted in Slovak televisions during the 2012 in selected four segments. Scientific aim Aim of this contribution is the introduction of preferences and frequency of usage of advertising appeals used in Slovak television advertising. Subsequenty, the exploration of the links between the selection of advertising appeals and cultural dimensions of Slovaks are analyzed. Findings The largest representation in analyzed television commercials in all examined segments has the appeal to relaxation.), followed by the appeal of suitable, then the appeal of saving, the appeal to patriotism, the appeal of natural and the appeal to affiliation. In the surveyed segments the preferences of individual advertising appeals are somehow different and reflect existing influence of product category on creative strategy. The findings show the positive relation between selection of advertising appeals and Slovak cultural dimensions. Conclusions The preset contribution shows the importance of studying cultural aspects of advertising and applying findings to the field of advertising. Some limitations of the study are stated and recommendations for further research are added at the end of the article. (shrink)

Our article is focused on selected socio-economic aspects of health literacy of poor persons in the South Bohemian Region. In addition to determining the level of health literacy, we test its relationship to income and education level and examine how difficult it is for the target group to pay for medicines and visit a physician if needed. We also focus on the causes of such difficulties. The research was conducted in 2016 on a sample of 254 persons entitled to state (...) material poverty benefits in the South Bohemian Region. A structured interview was used, including the administration of the short form of the standardized Health Literacy questionnaire, with several additional questions on the respondents’ socio-economic situation. The data were statistically processed using SPSS. The results showed the respondents had an insufficient level of health literacy, and that a high proportion had difficulty paying for medicines and visiting their physician when required. Health literacy is not related to income but to education level. (shrink)

[Reason – critique – openess.. The Living legacy of the philosophy of K. R. Popper ].

[On the Question of the Relationship between the Philosophy of Rádl and Masaryk].

What is education? What options does the educator have and what is expected from those who are being educated? What do education in the sense of paideia and the Christian educatio have in common? And what is the difference between those two notions? What does it mean to succeed in the drama of life and the world? Can the insightful (theoria) seeking of wisdom (sofia, sapientia) be separated from the effective (praxis) seeking of reason (fronésis, prudentia)? What is the purpose (...) of scholé and can it be experienced in schools today? How do today's schools prepare the youngest generation for the task of enhancing civil society? Is everyone able to relate to good? What does it mean to testify to the idea of good? These and other questions are asked in a dialogue of two teachers from the Czech Republic and Slovakia, respectively, who are concerned with philosophy, theology and pedagogy. The aim of the dialogue is to enter the Living school of thought, as founded by the Czech philosopher Radim Palouš (1924–2015), and to consider anew the topics he opened in his works. The dialogue embarks on a journey of searching for wisdom, by listening to words and the Word, by perceiving and contemplating experience, through reason and intuition, dialogue and acceptance in silence. It involves taking a closer look into the world that concerns everyone who are pupils, students, educators, teachers, educators – those who seek and who are sent, those longing and facing misunderstanding. It is an invitation to reflect on human life with humility and the awareness of human responsibility, in the hope that the pursuit of good, truth and beauty is intertwined with the task of succeeding as humans. (shrink)

Two main tendencies in postmodernism can be identified, neither providing much scope for developing a postmodern philosophy of science. According to the first, the world is fragmented into a plurality of autonomous local discourses, implying that any advice to scientists can be given only from within science and not from philosophers who stand outside ( above') science. According to the second, the meaning of signs is fundamentally elusive (poststructuralism and deconstruction). A deconstructive philosophy of science might be conceived of as (...) experimenting with scientific texts, but in that case the label philosophy' becomes a mere matter of convention. (shrink)

According to Gabriel Marcel, no task is more important and more complex than looking for ways of confronting and overcoming despair. Therefore, the search for the essence of hope is the objective of this paper. Reference is made to the theme of the open soul in Henri Bergson’s, Gabriel Marcel’s, and Jan Patočka’s works. Such a soul is not centred in itself; moreover, according to Marcel, hope and soul are intrinsically linked together. Hope opens people towards the future. The concept (...) of hope in the biblical context is shown briefly, according to which hope is in God (Ps 62:5), while God is coming to man. At the same time, biblical texts sketch a pathway to hope, setting out from suffering through endurance and character (Rom 5:3–4). The paper stresses that hope takes root in dialogue and that a person is empowered to adopt hope as a gift. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Against the Spirit of Foundations: Postmodernism and David Hume1 Zuzana Parusnikova Introduction David Hume lived at the very dawn ofthe modern age and belonged to the Scottish Enlightenment. The Enlightenment is often conceived of as the essence of modernity, thus standing in firm opposition to postmodernism. According to postmodernists, the Enlightenmentideal of a universal liberating rationality and the principle of universally shared norms ofhumanism have not only lost (...) their vigour and appeal, but have proved to be oppressive and downright authoritarian. The project of the Enlightenment should thus be abandoned. And yet, despite the fact that Hume chronologically belonged to modernity, I find striking similarities between his views and postmodernism. Over the years there have been many, typically modern, efforts to find some unity and to grasp the essence of Hume's philosophy, to provide some general interpretative angle by which it can appear as a consistent philosophical system. I want to argue that such an approach is neither necessary nor desirable because it deprives Hume's philosophy of its most appealing feature—his acceptance of and tolerance towards the irreconcilability of its sceptical and natural elements. There is no need to force Hume to fit neatly under any traditional philosophical label.2 The permanent inconsistency in his 'system' resulting from his firm anti-foundationalist attitude is not a defect but instead makes his philosophy far more intriguing. The disunity which can be found in Hume's texts is also the feature bringing him close to postmodernism. Postmodernism is a fuzzy area, difficult to approach let alone to define. It deliberately avoids defining itself and could even be seen as "the characteristic of a universe where there are no more definitions possible." 3 Postmodernism is not a homogeneous stage of thinking following after modernism (as the prefix 'post' misleadingly suggests), but rather deconstructs modernity without offering a new and coherent alternative. Therefore, paradoxically, while deconstructing we have to use thevocabularywhichis being deconstructed and cannotcompletely avoid the ' logos ofthe definition'. This feature is reflected in what Derrida calls 'writing under erasure': we write and erase at the same time—since our language is constructed upon the modern logocentrism, we have no choice but to Volume XLX Number 1 ZUZANA PARUSNIKOVA use it. As a result, interpreting the meaning of texts, although authoritarian in its original intention, reveals the illusory character of any ultimate interpretation. Texts are viewed as mysterious and confusinglabyrinths,bycontrasttothemodernobsession aboutclarity, precision, consistency and the possibility of decoding the exact, fundamental message they convey. Philosophy is no longer conceived ofas a questfor foundations, and philosophical texts are looked at from a new perspective: they are rather 'misread', 'misinterpreted' or read on the margins' in order to paralyse the oppressive interpretations seeking some foundational interpretative principle and imposing compulsory norms ofunderstanding.4 Hume's philosophy has suffered extensive abuse of this foundationalist kind. With rare exceptions (for example, Richard Popkin), most interpreters have tried to eliminate the inconsistencies and contradictions in his writings and to pigeon-hole him victoriously. But Hume has given them a hard time indeed. The reason he has been such a poser is, in my opinion, that he—like postmodernists—does not offer any foundationalist perspective. In fact, their firm antifoundationalism makes allies ofhim and postmodernists. Anti-foundationalism For postmodernism, philosophy ceases to enjoy its traditional privilege of being a foundationalist discipline in either a metaphysical or an epistemological sense. Philosophy does not reveal any hidden depths, any deeper truths. It does not provide any unique insights guiding us beyond the immense diversity ofthe world towards its essential unity (metaphysics), nor does itprovide anyepistemological clue tothe world. Philosophy is denied the function of an epistemological police organizing the world into a well-arranged, easily-surveyed picture. For postmodernists, this modern "fantasy to seize reality"and makeitfully transparent and communicable is a source of terror.5 Postmodernism views the desire to master reality as leading to intellectual dictatorship, by eliminating the relevance and the rights ofthe other" which does not conform to modern principles and is thus downgraded in the modern hierarchy. The theoretical core ofthis anti-foundationalism, in my opinion, is the poststructuralist theory of meaning, developing the structuralist view (of Saussure) that meaning is never... (shrink)

The paper analyses empirical research results comparing the impact of the medium (traditional, paper-based vs. screen-based) on the reading process and text comprehension. It focuses on two analytical approaches—the first looks at the construction of cognitive maps of texts and the other the material aspects of the medium – which enable readers to orientate themselves and to explore and interpret the text more comprehensively. The paper discusses differences in how readers approach textual meaning according to experience of using digital technologies, (...) the text, and reader experience and abilities. It concludes by arguing that strengthening these individual experiences and abilities is key to effective inference of textual meaning. (shrink)

The article discusses possible ways of overcoming the environmental crisis. It is based on Šmajs’ evolutionary ontological understanding of the environmental crisis of nature, which distinguishes between natural and cultural evolution and demonstrates the opposing relationships between them. It critically develops one of Šmajs’ proposals for initiating a biophilic transformation of culture by dealing with some of the consequences of the economic crisis (specifically unemployment).

The paper focuses on the so-called problemata, a topic that has not yet evoked much scholarly interest. In the beginning of the 15th century, problemata regularly occurred in the quodlibetal handbooks of the Prague University masters alongside the usual quaestiones. The paper introduces a catalogue of problemata found in the quodlibetal handbooks of the Prague University masters active between 1400 and 1417, i.e. John Arsen of Langenfeld, Matthias of Knín, John Hus, Simon of Tišnov, and Procopius of Kladruby. Moreover, it (...) provides a basic overview of how the individual authors of quodlibetal disputations formulated their problemata and the sources they used. (shrink)

The paper discusses inappropriate (futile) treatment by analyzing the casuistics of palliative patients in the terminal stage of illness who are hospitalized at the Department of Internal Medicine and Geriatrics of the Faculty hospital with policlinic (FNsP). Our research applies the principles of palliative care in the context of bioethics. The existing clinical conditions of healthcare in Slovakia are characteristic of making a taboo of the issues of inappropriate treatment of palliative patients. Inductive-deductive and normative clinical bioethics methods of palliative (...) care and ethical strategy are applied for defining issues found in inappropriate hemodialysis treatment. An algorithm of hemodialysis treatment requires the definition of those lege artis criteria which, in the context of a patient’s autonomy and his/her decision, precondition the avoidance of the situation in which hemodialysis treatment is inappropriate (futile). Futile treatment in a terminal condition is ethically inappropriate medical treatment that extends the suffering of patients and their relatives. Its definition is determined by the relevant legislation and the methods of bioethics. An active palliative strategy is aimed at managing the process of incurable diseases in the patient’s bio-psycho-socio-spiritual continuity in the process of special bioethics. The global bioethical objective of general bioethics for palliative care is based on the paradigm of social harmony and solidarity in the context of an authentic modus of the patient’s existence as a constitutive principle for the phenomenon of the patient’s being to finite being (death). (shrink)

Book review of KOPČÁKOVÁ, Slávka, (Ed.) – ORIŇÁKOVÁ, Slávka – ZUBAL, Pavol (2021) Tobias Gottfried Schröer (1791-1850). Estetika ako vízia lepšieho človeka. [Tobias Gottfried Schroer (1791-1850). Aesthetics as a vision of a better person.] Prešov: University of Prešov, Faculty of Arts. 321 p. ISBN 978-80-555-2767-3.