Most proposals for new international agreements aim to address important global challenges. If the goal is to solve problems, then the value of these agreements depends on their ability to influence the world — to shape norms, constrain behavior, facilitate cooperation, and mobilize action. A recent review of empirical studies has suggested that many international agreements fail to achieve their aspirations. The review indicates that the form in which states make commitments to each other — through an international legal agreement (...) or through other means — may not be as important as commonly thought. It is the content of the commitments and how these are supported by mechanisms to encourage implementation that matter the most. When developing proposals for new international agreements, like the one that has recently been proposed to address antibiotic resistance, attention to implementation mechanisms should therefore be equal to if not greater than the attention paid to its form. (shrink)

Proposes and defends a novel account of the mechanics of divine foreknowledge and providence, arguing that this account is consistent with libertarian freedom.

This article in an attempt to identify the precise way in which Robert Boyle provided a mechanical account of the features that distinguish liquids and air from solids and from each other. In his pneumatics, Boyle articulated his notion of the ‘spring’ of the air for that purpose. Pressure appeared there only in a common, rather than in a technical, sense. It was when he turned to hydrostatics that Boyle found the need to introduce a technical sense of pressure to (...) capture the fluidity of water which, unlike air, lacked a significant spring. Pressure, understood as representing the state of a liquid within the body of it rather than at its surface, enabled Boyle to trace the transmission of hydrostatic forces through liquids and thereby give a mechanical account of that transmission according to his understanding of the term. This was a major step towards the technical sense of pressure that was to be adopted in Newton’s hydrostatics and in fluid mechanics thereafter. (shrink)

The rise of the mechanistic worldview in the seventeenth century had a major impact on views of biological generation. Many seventeenth century naturalists rejected the old animist thesis. However, the alternative view of gradual mechanistic formation in embryology didn’t convince either. How to articulate the peculiarity of life? Researchers in the seventeenth century proposed both “animist” and mechanistic theories of life. In the eighteenth century again a controversy in biology arose regarding the explanation of generation. Some adhered to the view (...) that life is a physical property of matter (e.g. Buffon), others saw living entities as the result of the development of pre-existing germs (e.g. Bonnet). Naturalists, lacked a convincing account that could guide their research. In interaction with leading naturalists of his time Immanuel Kant articulated an approach to explaining generation. Kant’s account, delineated in his Kritik der Urteilskraft (Critique of the power of judgment) (1790), is a combination of Newtonian non-reductionist mechanism in explanation, and a concept of natural end comparable to Stahl’s formal conception of organic bodies. It consists of two claims: a) in biology only mechanical explanation is explanatory, and b) living entities contain some original organisation, which is mechanically unexplainable. In the nineteenth century this approach influenced naturalists as Müller, Virchow, and Von Baer, in their physiological research. Dissatisfied with a sheer mechanistic or, on the other hand, a sheer teleological approach, they appreciated the Kantian account of mechanical explanation of natural ends. In Germany, in the second halve of the nineteenth century, Ernst Haeckel reopened the debate about abiogenesis, which still continuous. (shrink)

This paper offers an account of what it is for a physical system to be a computing mechanism—a mechanism that performs computations. A computing mechanism is any mechanism whose functional analysis ascribes it the function of generating outputs strings from input strings in accordance with a general rule that applies to all strings. This account is motivated by reasons that are endogenous to the philosophy of computing, but it may also be seen as an application of recent literature on (...) class='Hi'>mechanisms. The account can be used to individuate computing mechanisms and the functions they compute and to taxonomize computing mechanisms based on their computing power. This makes it ideal for grounding the comparison and assessment of computational theories of mind and brain. (shrink)

U poslednjih nekoliko dekada vise studija posvecenih percepciji novorodjencadi je ukazalo na to da cak i tek rodjena deca jesu osetljiva na nacin na koji se objekti pokrecu i na prirodu njihove interakcije. Da bi objasnili ranu pojavu ovakve osetljivosti na kauzalne odnose neki psiholozi zastupaju stanoviste da postoji urodjeno znanje vezano za objekte. Cilj ovog rada je da preispita ovakva nativisticka objasnjenja tako sto ce da preispita da li ova objasnjenja ispunjavaju uslove koji svaki mehanicisticki model mora da ispuni (...) da bi bio uspesan. Craver je razvio nekoliko takvih kriterijuma kao i distinkciju izmedju odgovarajuceg mehanicistickog modela i mehanicisticke skice. Moj cilj je da pokazem da nativisticki modeli razvoja ne ispunjavaju ove kriterijume. Prvo, ti modeli samo delimicno a ne u potpunosti opisuju fenomen. Drugo, nativisti ukljucuju u opis fenomena odredjenu teoriju percepcije koja zahteva dodatnu empirijsku evidenciju i ne moze biti bezrezervno prihvacena kao tacna. Ja cu takodje argumentovati da je urodjeno znanje dobar kandidat za ono sto Craver naziva?praznim terminom? i da ce najverovatnije biti napusten. Novija istrazivanja koja su ispitivala intersenzornu percepciju ukazuju na to da je mehanizam odgovoran za rano opazanje kauzalnih odnosa najverovatnije deo nase najosnovnije fiziologije i da kao takav ne ukljucuje sofisticirane kognitivne strukture niti urodjeno znanje. Takodje, ova istrazivanja ukazuju na to da je standardna debata izmedju nativista i empirista pogresno postavljena i da bi je trebalo napustiti. (shrink)

Proponents of mechanistic explanations have recently proclaimed that all explanations in the neurosciences appeal to mechanisms. The purpose of the paper is to critically assess this statement and to develop an integrative account that connects a large range of both mechanistic and dynamical explanations. I develop and defend four theses about the relationship between dynamical and mechanistic explanations: that dynamical explanations are structurally grounded, that they are multiply realizable, possess realizing mechanisms and provide a powerful top-down heuristic. Four (...) examples shall support my points: the harmonic oscillator, the Haken–Kelso–Bunz model of bimanual coordination, the Watt governor and the Gierer–Meinhardt model of biological pattern formation. I also develop the picture of “horizontal” and “vertical” directions of explanations to illustrate the different perspectives of the dynamical and mechanistic approach as well as their potential integration by means of intersection points. (shrink)

Kant's account of Newtonian science in terms of a priori structures of the mind has been generally interpreted as too restrictive. If Newtonian science is an instantiation of the system of categories, then, in order to retain any value, they need to be dynamized in accordance with the development of science beyond Newton. This paper suggests that the restriction in best understood as Kant attempt to provide a primary matrix of sense for any possible natural science, inasmuch as it reflects (...) the "first idea" contained in the Copernican Revolution. (shrink)

Several recent findings support the notion that changes in the environment can be implicitly represented by the visual system. S. R. Mitroff, D. J. Simons, and S. L. Franconeri (2002) challenged this view and proposed alternative interpretations based on explicit strategies. Across 4 experiments, the current study finds no empirical support for such alternative proposals. Experiment 1 shows that subjects do not rely on unchanged items when locating an unaware change. Experiments 2 and 3 show that unaware changes affect performance (...) even when they occur at an unpredictable location. Experiment 4 shows that the unaware congruency effect does not depend simply on the pattern of the final display. The authors point to converging evidence from other methodologies and highlight several weaknesses in Mitroff et al.’s theoretical arguments. It is concluded here that implicit representation of change provides the most parsimonious explanation for both past and present findings. (shrink)

We contend that Ramsey et al.'s definition of animal innovation sensu process may be partially misleading when investigating mechanisms underlying animal innovation. By excluding social learning from the of innovation, they may be reproducing a dichotomous schema that does not accurately correspond to our knowledge of the acquisition of novel behavioral variants. This gives us some reason to doubt the functional specification of the defined process of innovation.

This paper will examine the nature of mechanisms and the distinction between the relevant and irrelevant parts involved in a mechanism’s operation. I first consider Craver’s account of this distinction in his book on the nature of mechanisms, and explain some problems. I then offer a novel account of the distinction that appeals to some resources from Mackie’s theory of causation. I end by explaining how this account enables us to better understand what mechanisms are and their (...) various features. (shrink)

Modularity theorists have challenged that there are, or could be, general learning mechanisms that explain theory-of-mind development. In response, supporters of the ‘scientific theory-theory’ account of theory-of-mind development have appealed to children's use of auxiliary hypotheses and probabilistic causal modeling. This article argues that these general learning mechanisms are not sufficient to meet the modularist's challenge. The article then explores an alternative domain-general learning mechanism by proposing that children grasp the concept belief through the progressive alignment of relational (...) structure that occurs as a result of structural-comparison. The article also explores the implications of the proposed account for Fodor's puzzle of conceptual learning. (shrink)

Mechanisms are now taken widely in philosophy of science to provide one of modern science’s basic explanatory devices. This has raised lively debate concerning the relationship between mechanisms, laws and explanation. This paper focuses on cases where a mechanism gives rise to a ceteris paribus law, addressing two inter-related questions: What kind of explanation is involved? and What is going on in the world when mechanism M affords behavior B described in a ceteris paribus law? We explore various (...) answers offered by ‘new mechanists’ and others before setting out and explaining our own answers: mechanistic explanations are a species of oldfashioned covering-law explanation and this often accounts in part for their explanatory power; and B is what it takes for some set of principles that govern the features of M’s parts in their arrangement in M all to be instanced together. (shrink)

The new mechanistic philosophy is divided into two largely disconnected projects. One deals with a metaphysical inquiry into how mechanisms relate to issues such as causation, capacities and levels of organization, while the other deals with epistemic issues related to the discovery of mechanisms and the intelligibility of mechanistic representations. Tudor Baetu explores and explains these projects, and shows how the gap between them can be bridged. His proposed account is compatible both with the assumptions and practices of (...) experimental design in biological research, and with scientifically accepted interpretations of experimental results. (shrink)

Today, mechanisms and mechanistic explanation are very popular in philosophy of science and are deemed a welcome alternative to laws of nature and deductive‐nomological explanation. Starting from Mitchell's pragmatic notion of laws, I cast doubt on their status as a genuine alternative. I argue that (1) all complex‐systems mechanisms ontologically must rely on stable regularities, while (2) the reverse need not hold. Analogously, (3) models of mechanisms must incorporate pragmatic laws, while (4) such laws themselves need not (...) always refer to underlying mechanisms. Finally, I show that Mitchell's account is more encompassing than the mechanistic account *Received August 2008; revised January 2010. †To contact the author, please write to: Centre for Logic and Philosophy of Science, Ghent University, Blandijnberg 2, B‐9000 Belgium; e‐mail: [email protected]. (shrink)

With In Search of Mechanisms, Carl F. Craver and Lindley Darden offer both a descriptive and an instructional account of how biologists discover mechanisms. Drawing on examples from across the life sciences and through the centuries, Craver and Darden compile an impressive toolbox of strategies that biologists have used and will use again to reveal the mechanisms that produce, underlie, or maintain the phenomena characteristic of living things. They discuss the questions that figure in the search for (...) mechanisms, characterizing the experimental, observational, and conceptual considerations used to answer them, all the while providing examples from the history of biology to highlight the kinds of evidence and reasoning strategies employed to assess mechanisms. At a deeper level, Craver and Darden pose a systematic view of what biology is, of how biology makes progress, of how biological discoveries are and might be made, and of why knowledge of biological mechanisms is important for the future of the human species. (shrink)

Internal mechanisms, especially those implicating the self, are crucial for the egoism-altruism debate. Self-liking is extended to close others and can be extended, through socialization and reinforcement experiences, to non-close others: Altruistic responses are directed toward others who are included in the self. The process of self-extension can account for cross-situational variability, contextual variability, and individual differences in altruistic behavior.

Mechanisms are often characterized as causal structures and the interventionist account of causation is then used to characterize what it is to be a causal structure. The associated modularity constraint on causal structures has evoked criticism against using the theory as an account of mechanisms, since many mechanisms seem to violate modularity. This paper answers to this criticism by making a distinction between a causal system and a causal structure. It makes sense to ask what the modularity (...) properties of a given causal structure are, but not whether a causal system is modular tout court. The counter-examples to the interventionist account are systems in which a particular structure is modular in variables, but not in parameters. A failure of parameter-modularity does not by itself threaten the interventionist interpretation of the structure and the possibility of causally explaining with that structure, but it does mean that knowledge of the structure is not sufficient to constitutively explain system-level properties of the embedding system. (shrink)

his monograph examines the metaphysical commitments of the new mechanistic philosophy, a way of thinking that has returned to center stage. It challenges a variant of reductionism with regard to higher-level phenomena, which has crystallized as a default position among these so-called New Mechanists. Furthermore, it opposes those philosophers who reject the possibility of interlevel causation. Contemporary philosophers believe that the explanation of scientific phenomena requires the discovery of relevant mechanisms. As a result, new mechanists are, in the main, (...) concerned solely with epistemological questions. But, the author argues, their most central claims rely on metaphysical assumptions. Thus, they must also take into account metaphysics, a system of thought concerned with explaining the fundamental nature of being and the world around it. This branch of philosophy does indeed matter to the empirical sciences. The chapters investigate the nature of mechanisms, their components, and the ways in which they can bring about different phenomena. In addition, the author develops a novel account of causation in terms of activities. The analysis provides the basis for many further research projects on mechanisms and their relations to, for example, the mind-body problem, realization, multiple realization, natural kinds, causation, laws of nature, counterfactuals, and scientific levels. (shrink)

We need not propose, as Carey does, a radical discontinuity between core cognition, which is responsible for abstract structure, and language and which are responsible for learning and conceptual change. From a probabilistic models view, conceptual structure and learning reflect the same principles, and they are both in place from the beginning.

In this article, I present two conceptual problems for Craver's mutual manipulability account of constitutive relevance in mechanisms. First, constitutive relevance threatens to imply causal relevance despite Craver (and Bechtel)'s claim that they are strictly distinct. Second, if (as is intuitively appealing) parthood is defined in terms of spatio-temporal inclusion, then the mutual manipulability account is prone to counterexamples, as I show by a case of endosymbiosis. I also present a methodological problem (a case of experimental underdetermination) and formulate (...) two partial, but fallible solutions based on the notions of parthood and synchronicity. (shrink)

A serious flaw in Hartry Field’s instrumental account of applied mathematics, namely that Field must overestimate the extent to which many of the structures of our mathematical theories are reflected in the physical world, underlies much of the criticism of this account. After reviewing some of this criticism, I illustrate through an examination of the prospects for extending Field’s account to classical equilibrium statistical mechanics how this flaw will prevent any significant extension of this account beyond field theories. I note (...) in the conclusion that this diagnosis of Field’s program also points the way to modifications that may work. (shrink)

Quantum mechanics arguably provides the best evidence we have for strong emergence. Entangled pairs of particles apparently have properties that fail to supervene on the properties of the particles taken individually. But at the same time, quantum mechanics is a terrible place to look for evidence of strong emergence: the interpretation of the theory is so contested that drawing any metaphysical conclusions from it is risky at best. I run through the standard argument for strong emergence based on entanglement, and (...) show how it rests on shaky assumptions concerning the ontology of the quantum world. In particular, I consider two objections: that the argument involves Bell's theorem, whose premises are often rejected, and that the argument rests on a contested account of parts and wholes. I respond to both objections, showing that, with some important caveats, the argument for emergence based on quantum mechanics remains intact. (shrink)

According to a widely held view, scientific modelling consists in entertaining a set of model descriptions that specify a model. Rather than studying the phenomenon of interest directly, scientists investigate the phenomenon indirectly via a model in the hope of learning about some of the phenomenon’s features. I call this view the description-driven modelling (DDM) account. I argue that although an accurate description of much of scientific research, the DDM account is found wanting as regards the mechanistic modelling found in (...) many branches of biology. By analysing research practices in cancer immunology concerning the development of mechanistic models of the process of cancer metastasis, this paper presents and argues for a complementary account of scientific modelling, herein called the experimentation-driven modelling (EDM) account. In EDM, scientists investigate a set of experimental systems and then integrate the results obtained from experiments into a mechanistic model. While EDM shares some key features with DDM, the two are epistemically very different approaches to research. (shrink)

Government accountability is generally accepted to be an essential feature of modern democratic society; while others might turn a blind eye to corruption and wrongdoing, those who value accountability would instead shine a bright light on it. In this context, it is common to hear claims of accountability 'deficit' and 'overload'. Despite the frequency of references to these concepts, their precise content remains undeveloped. This book offers an explanation, as well as a framework for future exploration, of (...) these concepts. It highlights the difficulty of defining a benchmark that might be used to measure the amount of accountability in a particular situation, and also the challenge of mapping out accountability mechanisms as a system. While difficult, if accountability is indeed a foundational concept underpinning our system of government, there is merit in meeting these challenges head-on. (shrink)

Several authors have claimed that mechanisms play a vital role in distinguishing between causation and mere correlation in the social sciences. Such claims are sometimes interpreted to mean that without mechanisms, causal inference in social science is impossible. The author agrees with critics of this proposition but explains how the account of how mechanisms aid causal inference can be interpreted in a way that does not depend on it. Nevertheless, he shows that this more charitable version of (...) the account is still unsuccessful as it stands. Consequently, he advances a proposal for shoring up the account, which is founded on the possibility of acquiring knowledge of social mechanisms by linking together norms or practices found in a society. Key Words: causality • social mechanisms • interpretation • anthropology. (shrink)

This is a brief account of a theory of presentiment/retrocausation in the context of a proposed binocular rivalry experiment. According to orthodox (classical or quantum mechanical) physics there can be no retrocausal effects. In order to accommodate such effects one must go beyond/outside orthodox theories. The simplest way to modify QM in a way that would permit such effects is to accept the hypothesis of Eccles (1987) that mental involvement (mental effort or emotion) can alter the orthodox statistical weighting factors (...) associated with the observed outcomes of our experimental probing actions. (shrink)

Most philosophical accounts of causation take causal relations to obtain between individuals and events in virtue of nomological relations between properties of these individuals and events. Such views fail to take into account the consequences of the fact that in general the properties of individuals and events will depend upon mechanisms that realize those properties. In this paper I attempt to rectify this failure, and in so doing to provide an account of the causal relevance of higher-level properties. I (...) do this by critiquing one prominent model of higher-level properties—Kim’s functional model of reduction—and contrasting it with a mechanistic approach to higher-level properties and causation. (shrink)

Philosophers of science increasingly believe that much of science is concerned with understanding the mechanisms responsible for the production of natural phenomena. An adequate understanding of scientific research requires an account of how scientists develop and test models of mechanisms. This paper offers a general account of the nature of mechanical models, discussing the representational relationship that holds between mechanisms and their models as well as the techniques that can be used to test and refine such models. (...) The analysis is supported by study of two competing models of a mechanism of speech perception. (shrink)

Experimental investigation of mechanisms seems to make use of causal relations that cut across levels of composition. In bottom-up experiments, one intervenes on parts of a mechanism to observe the whole; in top-down experiments, one intervenes on the whole mechanism to observe certain parts of it. It is controversial whether such experiments really make use of interlevel causation, and indeed whether the idea of causation across levels is even conceptually coherent. Craver and Bechtel have suggested that interlevel causal claims (...) can be analysed in a causal and a non-causal component. I accept this idea but argue that their account should be modified so as to account of cases of apparent downward causation. First, constitution must be distinguished from identity; second, the analysis of downward causation requires the concept of a partial constraint. An analysis along these lines shows that the possibility of downward causation is not refuted by Kim's argument according to which it is incompatible with the completeness of physics. (shrink)

In this paper I offer an analysis of causation based upon a theory of mechanisms-complex systems whose internal parts interact to produce a system's external behavior. I argue that all but the fundamental laws of physics can be explained by reference to mechanisms. Mechanisms provide an epistemologically unproblematic way to explain the necessity which is often taken to distinguish laws from other generalizations. This account of necessity leads to a theory of causation according to which events are (...) causally related when there is a mechanism that connects them. I present reasons why the lack of an account of fundamental physical causation does not undermine the mechanical account. (shrink)

This paper argues that current accountability mechanisms are inadequate to ensure that straight-commissioned agents meet their fiduciary obligations to their clients. In doing so, using agency theory, it revisits how the straight-commission compensation system creates agents’ dueling loyalties and recommends mechanisms of accountability organizations, agents, and/or clients can recognize and employ to ensure agents’ fiduciary obligations to their clients.

Interpretations of Quantum Mechanics Quantum mechanics is a physical theory developed in the 1920s to account for the behavior of matter on the atomic scale. It has subsequently been developed into arguably the most empirically successful theory in the history of physics. However, it is hard to understand quantum mechanics as a description of the … Continue reading Quantum Mechanics, Interpretations of →.

This article focuses on emergence in social systems. The author begins by proposing a new tool to explore the mechanisms of social emergence: multi agent–based computer simulation. He then draws on philosophy of mind to develop an account of social emergence that raises potential problems for the methodological individualism of both social mechanism and of multi agent simulation. He then draws on various complexity concepts to propose a set of criteria whereby one can determine whether a given social mechanism (...) generates emergent properties, in the sense that their explanation cannot be reduced to a mechanistic account of individuals and their interactions. This combined account helps to resolve the competing claims of methodological individualists and social realists. The author’s conclusion is that the scope of mechanistic explanation may be limited due to the extreme complexity of many social systems. Key Words: emergence • mechanism • computer simulation • methodological individualism • social realism. (shrink)

In this chapter, I sketch the history of mechanistic models of the mental, as related to the technological project of trying to build mechanical minds, and discuss the contemporary debates on psychological and cognitive explanations. In the first section, I introduce the Cartesian notion of mechanism, which has shaped the debate in the centuries to follow. Early mechanistic proposals are also connected with early attempts to formulate the computational account of thinking and reasoning, upheld notably by Hobbes and Leibniz. In (...) the second section, associationist and behaviorist models of the mind are sketched, along with attempts to understand the neural system in terms of connections and associations. Early robotic models, built mostly by behaviorists and other students of animal behavior, are also introduced. In the third section, the focus is on early computational and cybernetic models of the mind. In the fourth section, I deal with computational models of mental mechanisms as proposed by students of artificial intelligence and cognitive science. Then, I sketch the contemporary debate over the question whether computational and psychological models are best understood as offering functional, or maybe mechanistic explanations. (shrink)

Leuridan (2010) argued that mechanisms cannot provide a genuine alternative to laws of nature as a model of explanation in the sciences, and advocates Mitchell’s (1997) pragmatic account of laws. I first demonstrate that Leuridan gets the order of priority wrong between mechanisms, regularity, and laws, and then make some clarifying remarks about how laws and mechanisms relate to regularities. Mechanisms are not an explanatory alternative to regularities; they are an alternative to laws. The existence of (...) stable regularities in nature is necessary for either model of explanation: regularities are what laws describe and what mechanisms explain. (shrink)

Life-science phenomena are often explained by specifying the mechanisms that bring them about. The new mechanistic philosophers have done much to substantiate this claim and to provide us with a better understanding of what mechanisms are and how they explain. Although there is disagreement among current mechanists on various issues, they share a common core position and a seeming commitment to some form of scientific realism. But is such a commitment necessary? Is it the best way to go (...) about mechanistic explanation? In this article, we propose an alternative antirealist account that also fits explanatory practice in the life sciences. We pay special attention to mechanistic models, i.e. scientific models that involve a mechanism, and to the role of coherence considerations in building such models. To illustrate our points, we consider the mechanism for the action potential. 1 Introduction2 Some Core Features of Mechanistic Explanation3 Scientific Realism and Mechanistic Explanation4 Antirealist Mechanistic Explanation: The Case of the Action Potential5 Some Outstanding Issues for the Antirealist Mechanist6 Two Problems for the Realist Mechanist7 Conclusions. (shrink)

mechanism" is frequently encountered in the social science literature, but there is considerable confusion about the exact meaning of the term. The article begins by addressing the main conceptual issues. Use of this term is the hallmark of an approach that is critical of the explanatory deficits of correlational analysis and of the covering-law model, advocating instead the causal reconstruction of the processes that account for given macro-phenomena. The term "social mechanisms" should be used to refer to recurrent processes (...) generating a specific kind of outcome. Explanation of social macro-phenomena by mechanisms typically involves causal regression to lower-level elements, as stipulated by methodological individualism. While there exist a good many mechanism models to explain emergent effects of collective behavior, we lack a similarly systematic treatment of generative mechanisms in which institutions and specific kinds of structural configurations play the decisive role. Key Words: causal regression • correlational analysis • emergent effects • micro-macro processes • social mechanisms • structural determinants. (shrink)

During the past two decades, philosophers of biology have increasingly turned their attention to mechanisms of biological phenomena. Through analyses of mechanistic proposals advanced by biologists, the goal of these philosophers is to understand what a mechanism is and how mechanisms explain. These analyses have generally focused on mechanistic proposals for phenomenon that occur at the cellular or sub-cellular level, such as synapse firing, protein synthesis, or metabolic pathway operation. Little is said about the mechanisms of the (...) macromolecular reactions that underpin these phenomena. These reactions comprise a diverse family of reaction types, and include protein folding, macromolecular complex formation, receptor-ligand interactions, and enzyme catalysis. In this paper, I develop an account of mechanism that focuses exclusively on macromolecular reactions. I begin by reviewing how mechanism is understood in enzymology, and how mechanistic concepts of enzymology apply to macromolecular reactions in general. We will see that the mechanism of a macromolecular reaction is most accurately described as a progression of reaction intermediates, where the evolution of intermediates, from one to the next, is characterized by an energetic coupling between chemistry and protein dynamics. I then make the case that this description necessitates a grounding in a process ontology. To describe the mechanism by which a macromolecular reaction occurs is to describe a process. (shrink)

The notion of an accountability deficit is particularly associated with the absence of political control by democratically elected political representatives. The main sites for such a deficit are international relations, decoupling of responsibility for public services, and networked governance. Analysis of the deficit has prompted emphasis on alternative accountability mechanics as well as alternative definitions of “accountability” itself. To be useful, the concept should be widened beyond political control to include possible deficits in any type of (...) class='Hi'>accountability. Any claim to a particular accountability deficit needs to be made against a standard or yardstick of that type of accountability without the deficit. The normative implications of any particular deficit should also be made explicit, given that in some circumstances, such as accountability “overload”, a reduction in accountability can be viewed positively. (shrink)

In this paper examine the relation between the account of mechanical memory in Hegel’s Encyclopedia of the Philosophical Sciences and the speculative sentence in his Phenomenology of Spirit. Both accounts involve a transition to speculative thinking, a kind of thinking that is free from given images and representations. By discussing them together I hope to illuminate how speculative thinking functions for Hegel and why it is important. Specifically, I try to show how what Hegel calls mechanical memory can shed light (...) on Hegel’s more familiar notion of the speculative sentence. I also draw out implications of language and mechanical memory for what Hegel calls speculative thinking. First, I examine Hegel’s account of language acquisition in the Encyclopedia, which involves an account of mechanical memory, to show how Hegel thinks the mind can produce a vehicle for thinking that it has produced both in form and content. Second, I show how this vehicle of language works in the speculative sentence in the Phenomenology. (shrink)

In recent years what has come to be called the 'New Mechanism' has emerged as a framework for thinking about the philosophical assumptions underlying many areas of science, especially in sciences such as biology, neuroscience, and psychology. This book offers a fresh look at the role of mechanisms, by situating novel analyses of central philosophical issues related to mechanisms within a rich historical perspective of the concept of mechanism as well as detailed case studies of biological mechanisms. (...) It develops a new position, Methodological Mechanism, according to which mechanisms are to be viewed as causal pathways that are theoretically described and are underpinned by networks of difference-making relations. In contrast to metaphysically inflated accounts, this study characterises mechanism as a concept-in-use in science that is deflationary and metaphysically neutral, but still methodologically useful and central to scientific practice. (shrink)