This paper is a critique of NIH guidelines for the care and protection of laboratory animals. It exposes four serious deficiencies in these guidelines: (1) failure to make it dear that the mere pursuit of knowledge does not justify using animals; (2) failure to give any guidance concerning what constitutes human benefit or well-being; (3) failure to countenance trade-offs between human benefit or well-being and animal well-being; (4) failure to clearly specify what constitutes keeping animals in an ‘environment appropriate to (...) the species and its life history.’ It concludes with the suggestion that the construction and revision of these guidelines is too important to be left to the professionals. Keywords: animals, benefit, NIH, research, trade-offs, well-being CiteULike Connotea Del.icio.us What's this? (shrink)

Scientific research is supposed to acquire or generate knowledge, but such a purpose would be severely undermined by instances of research misconduct (RM) and questionable research practices (QRP). RM and QRP are often framed in terms of moral transgressions by individuals (bad apples) whose aberrant acts could be made conducive by shortcomings in regulatory measures of organizations or institutions (bad barrels). This notion presupposes, to an extent, that the erring parties know exactly what they are doing is wrong and morally (...) culpable, but had nonetheless proceeded to commit wrongful acts. However, a confession of intent to deceived is often not readily admitted by perpetrators of RM. I posit that beyond the simplistic notion of conscious moral transgression, deficits in epistemic virtues and/or the prevalence of epistemic vices have important roles to play in initiating and driving RM/QRP. For the individual perpetrator, deficits in epistemic virtues could lead to or amplify errors in one’s desperate attempt to be accomplished or to excel, and pushes one across the ethical line or down the slippery slope of misconduct. Likewise, a lack of epistemic virtue within perpetrators’ institution or organization could make it conducive for deceitful acts and suppress indications and warning signs for the former. Furthermore, epistemic vices exhibited by reviewers, editors and journals could also promote RM/QRP. In this view, epistemic failings, rather than widespread moral deficiencies of individuals within the research ecosystem, may underlie the prevalence of RM/QRP. (shrink)

Although higher education understands the need to develop critical thinkers, it has not lived up to the task consistently. Students are graduating deficient in these skills, unprepared to think critically once in the workforce. Limited development of cognitive processing skills leads to less effective leaders. Various definitions of critical thinking are examined to develop a general construct to guide the discussion as critical thinking is linked to constructivism, leadership, and education. Most pedagogy is content-based built on deep knowledge. Successful (...) critical thinking pedagogy is moving away from this paradigm, teaching students to think complexly. Some of the challenges faced by higher education moving to a critical thinking curricula are discussed, and recommendations are offered for improving outcomes. (shrink)

This paper delves into crucial issues surrounding attempts to make flawless Qur’anic recitation, in Nigeria, a permanent tradition. The paper identifies major militating factors against an error-free recitation of the holy Qur’an in Nigeria as a basis for locating appropriate remedial programmes. The study discovered that factors such as acquisition of deficient typologies, language interference, complexity of the rules, lack of awareness dearth of specialists , dearth of relevant texts , underutilization of orthographic symbols and methodology used in imparting (...) the knowledge constitute major impediments towards achieving ideal recital of the Qur’an. In proffering relevant remedial measures like the teaching of the ideal typologies of Qur’anic recitation supported by a well planned curriculum, the paper concludes that the rectification of diagnosed deficiencies in reciting the Qur’an is feasible, in the long run, provided the intervention strategies proposed are effectively implemented. (shrink)

I give a brief overview of Albert Casullo’s Essays on A Priori Knowledge and Justification (2012), followed by a summary of his diagnostic framework for evaluating accounts of a priori knowledge and a priori justification. I then discuss Casullo’s strategy for countering deficiency arguments against empiricism. A deficiency argument against empiricism can be countered by mounting a parallel argument against moderate rationalism that shows moderate rationalism to be defective in a similar way. I argue that a particular deficiency argument put (...) forth by George Bealer in “The Incoherence of Empiricism” (1992) can withstand a parallel challenge mounted by Casullo (2012, Ch.6). -/- I then consider Casullo’s preferred analysis of the concept of a priori justification, which identifies a belief’s being justified by some nonexperiential source as the feature by virtue of which it is justified a priori. On the analysis, an apriori-justfied belief that is justified to a degree that is sufficient for knowledge is not taken to be empirically indefeasible. I argue that Casullo could avail himself of an empirical indefeasibility requirement that is consistent with his minimal and fallibilist conception of a priori knowledge. Doing so would capture a feature of the concept of a priori knowledge that is of particular interest and significance. (shrink)

The contemporary debate on justice is understandably dominated by theories and arguments addressing the problems of justice pertinent to nearly just societies, as virtually all the theorists participating in this debate live in such societies. They are obviously, and rightly so, first and foremost concerned with the philosophical problems of their own societies. Although almost all the contemporary theories of justice were formulated in the context of nearly just societies, why can we not apply them to the issues and problems (...) of radically unjust societies? The view that such a move is permissible and wise is at present no more than an unexamined assumption, an unargued view. Such an unargued view leads to the suspicion that a strong case may be made that radically unjust societies generate problems of social and political justice that should be considered in their own right. This does not imply that theories of justice developed in the context of, and aimed at, those issues current in nearly just societies should be disregarded or discarded. What is required are arguments to indicate to what extent the theoretical insights and wisdom contained in these theories can be utilized in a discussion of the social and political problems of radically unjust societies. I argue for the view that the contemporary debate on justice contains a major deficiency. In this article, I attempt to specify this major deficiency, namely that exclusive attention is given to the problems of nearly just societies while the problems of radically unjust societies are mostly ignored. The strategy will be to raise issues pertinent to radically unjust societies and note the extent to which clear and unambiguous solutions could be provided by participants in the contemporary debate on justice. (shrink)

A natural heme deficiency that exists in cells outside of the circulation broadly compromises the heme contents and functions of heme proteins in cells and tissues. Recently, we found that the signaling molecule, nitric oxide (NO), can trigger or repress the deployment of intracellular heme in a concentration‐dependent hormetic manner. This uncovers a new role for NO and sets the stage for it to shape numerous biological processes by controlling heme deployment and consequent heme protein functions in biology.

Paul Ricœur says that our narrative identity depends on how others understand us. This claim, however, does not explicitly address the fact that not everyone receives the same recognition: it underexplains how certain groups are systemically not acknowledged, respected, or taken seriously. More recent work on narrative co-authoring starts to address this fact by examining how people’s vulnerability to co-authoring depends on the context in which they live. But I argue that this work should be extended to attend to the (...) kinds of vulnerabilities that result from what José Medina calls recognition deficiencies, which become more normalized due to structural oppression, specifically what Iris Marion Young calls cultural imperialism. I then illuminate the kinds of vulnerabilities that result from recognition deficiencies in cases of structural oppression by bringing in work in Black feminist thought and epistemic injustice, particularly that of Audre Lorde and Veronica Ivy, into conversation with narrative scholarship. (shrink)

As the world's literary, religious, and philosophical traditions attest, deficiency in the world is a matter of perennial human concern. Ontologically speaking deficient existence is a problem that has occupied metaphysical thinking from Heraclitus to Heidegger. What is it to exist deficiently? ;This dissertation addresses the question, first, through a survey of answers given by six ancient philosophers. Parmenides describes deficient existence as changing multiplicity; Plato, as being in an inferior world; Plotinus, as mis-seeing; Augustine, as disorderedness; Gregory (...) of Nyssa, as "nothingification" &parl0;`h e ,xoud e&d12;nwsi v&parr0; ; Dionysius, as failed participation. The dissertation then gives a more systematic answer through close study of the metaphysics of John Scotus Eriugena , who builds on the foundation established by these thinkers. ;The Eriugenian cosmos is a "theophanic" one. To be is to be the showing or expression of God. What exists, then, is divine and good. Furthermore, all deficiencies, such as they are, must be characterized as privations or impoverishments. ;What can deficient existence be in such a world? Eriugena's first answer is that it is existence on an inferior level of reality. This dualistic view must be rejected, however, because it is not consistent with the fundamental metaphysical principles that reality is an ontological unity and every being is divine. ;Two better descriptions of deficient existence can be found in his metaphysics. First, to be deficiently is to see the world deficiently; that is, deficient existence is a misunderstanding of reality. Second, deficient existence is metaphysically incomplete existence. Being as a whole is an ontological work in progress, a creatio ex nihilo that is a creatio ex nihilo hic et illuc et ubique ---here, there, and everywhere. ;Such a creation depends in part on human choice and is subject to the destructive influences of non-being. But rather than a fall from some primordial perfection, creation is a movement towards perfection. Hence the existence that it constitutes is an existence in the theophanic world. Moreover, creation is theophanic to the extent that it does exist, even though, as deficient, it does not yet fully exist. (shrink)

Jennifer Lackey presents a puzzle to which she argues there is no current solution. Lackey's claim is that testimonial knowledge can have something conspicuously wrong with it and still be knowledge. Testimonial knowledge can be ‘deficient’. Given that knowledge is a normative category, that it describes what it is for a belief to go right, there is a puzzle that comes with accounting for how a testimonial belief could be knowledge and yet go wrong in the ways Lackey has (...) in mind. In this paper, I argue that the deficiency is one of teamwork, and that Lackey's puzzle offers one a window into the respect in which testimony is a kind of team achievement. (shrink)

This study explored how perceived control affects consumers' willingness to purchase self-improvement products under self-deficit situations. For this purpose, three experiments were conducted to examine the following sources of control: the controllability of self-deficits ; the locus of control ; and situational perceived control. According to the results, higher perceived control can reduce consumers' defensive reaction tendencies, thus increasing their willingness to purchase products that claim to improve their current deficits. Moreover, the aforementioned effect only occurs in within-domain improvement products, (...) rather than without-domain improvement products. (shrink)

This enlightening text analyses the origins of Western complaints, prevalent in the late nineteenth century, that Japan was characterised at the time by exceptionally low standards of ‘commercial morality’, despite a major political and economic transformation. As Britain industrialised during the nineteenth century the issue of ‘commercial morality’ was increasingly debated. Concerns about standards of business ethics extended to other industrialising economies, such as the United States. Hunter examines the Japanese response to the charges levelled against Japan in this context, (...) arguing that this was shaped by a pragmatic recognition that Japan had little choice but to adapt itself to Western expectations if it was to establish its position in the global economy. The controversy and criticisms, which were at least in part stimulated by fear of Japanese competition, are important in the history of thinking on business ethics, and are of relevance for today’s industrialising economies as they attempt to establish themselves in international markets. (shrink)

Theories of distributive justice are often criticised for either excluding people with disabilities from the domain of justice altogether, or casting them as deficient in personal attributes. I argue that the capabilities approach to justice is largely immune to these flaws. It has the conceptual resources to locate most of the causes of disadvantage in the interaction between a person and her environment and in doing so can characterise the disadvantages of disability in a way that avoids the imputation (...) of natural deficiency. However, I also argue that the capabilities approach cannot accommodate some of the stronger claims advanced by some disability scholars. No plausible capabilities approach can guarantee that social change will always be the just or fair remedy for disadvantage, and there is a small number of severe cases of disability where capability shortfalls will be attributed to the person’s ‘deficient’ physical and mental impairments. (shrink)

The authors analyze deficiencies and perils of the European Convention on Human Rights and Biomedicine , in particular the concept of human rights as given by natural law and the Conventions stand on germline therapy and its refutation of therapeutic enhancement.

Plato seems to have been pessimistic about how most people stand with regard to virtue. However, unlike the Stoics, he did not conclude that most people are vicious. Rather, as we know from discussions across several dialogues, he countenanced decent ethical conditions that fall short of genuine virtue, which he limited to the philosopher. Despite Plato's obvious interest in this issue, commentators rarely follow his lead by investigating in detail such conditions in the dialogues. When scholars do investigate what kind (...) of virtue, if any, Plato thinks is open to non-philosophers, they typically look to the Republic. But in the Republic Plato sets out an ideal city; therefore, the virtue available to non-philosophers there is likely different from what he thinks is available to them in the real world. If we want to determine Plato's thoughts about the virtue of actual non-philosophers, we must look elsewhere. In this paper, I set my sights on the Phaedo. (shrink)

이 연구는 토마스 아퀴나스의 『신학대전』 제1부 제49문 제1절과 『악론』 제1문제3절의 번역 및 해제를 목적으로 한다. 비슷한 시기의 작품으로 보이는 두 텍스트는 모두 ‘선이 악의 원인인가?’라는 문제를 다루면서, 모두 ‘악의 원인’에 대해‘형이상학적’ 관점에서 고찰한다. 이 연구는 두 텍스트를 특히 ‘어떤 의미에서 결함있는 선으로서 의지가 도덕적 악의 원인이 되는가’라는 문제에 집중해서 번역하고 해제를 하였다. 토마스는 『신학대전』과 『악론』에서 모두 도덕적 악이라는 행위의 결함 이전에 그것의 원인으로서 의지 안에서 발견되는 어떤 결함을 전제한다고 주장한다. 즉 『신학대전』에의 텍스트에 따르면 죄과는 의지가 자기의 규칙에 복종하지 않는 한에서 (...) 생겨나는, 현실적으로 결함 있는 의지에 의해 수행된 ‘행위’의 ‘결함’이다. 『악론』의 텍스트는 이 의지 안에 전제되는 결함은 구체적으로 ‘이성과 신법의 규칙을 사용하지 않음’이라고 말한다. 그런데 이 결함은 그 자체로는 죄과의 악도벌의 악도 아닌, 오직 “부정”일 뿐이고, ‘이성의 규칙과 신법을 사용하지 않음’이라는, 단순한 부정으로서의 결함이 ‘이성의 규칙과 신법을 사용해야 함’에도 사용하지 않고 행위가 실행되었을 때 비로소 죄과의 규정을 갖게 된다. ‘결함 있는 한에서의 의지’의 결함은 그것의 원인이 바로 ‘의지의 자유’에 있으며, 그래서 ‘의지적인 것’이지만, 그 자체로는 ‘악한 행위(현실태)’가 아니며, 또한 ‘악을 향한 인간의 근본 성향’을 설명해 주는 것으로 평가 받는 ‘원죄’ 및 ‘원죄의 벌’과도 구별되는, 무로부터의 창조에 근거한 ‘악한 행위의 형이상학적 조건’이라 할 수 있다. (shrink)

A high percent of oxidative energy metabolism is needed to support brain growth during infancy. Unhealthy diets and limited nutrition, as well as other environmental insults, can compromise these essential developmental processes. In particular, iron deficiency anemia has been found to undermine both normal brain growth and neurobehavioral development. Even moderate ID may affect neural maturation because when iron is limited, it is prioritized first to red blood cells over the brain. A primate model was used to investigate the neural (...) effects of a transient ID and if deficits would persist after iron treatment. The large size and postnatal growth of the monkey brain makes the findings relevant to the metabolic and iron needs of human infants, and initiating treatment upon diagnosis of anemia reflects clinical practice. Specifically, this analysis determined whether brain maturation would still be compromised at 1 year of age if an anemic infant was treated promptly once diagnosed. The hematology and iron status of 41 infant rhesus monkeys was screened at 2-month intervals. Fifteen became ID; 12 met clinical criteria for anemia and were administered iron dextran and B vitamins for 1–2 months. MRI scans were acquired at 1 year. The volumetric and diffusion tensor imaging measures from the ID infants were compared with monkeys who remained continuously iron sufficient. A prior history of ID was associated with smaller total brain volumes, driven primarily by significantly less total gray matter and smaller GM volumes in several cortical regions. At the macrostructual level, the effect on white matter volumes was not as overt. However, DTI analyses of WM microstructure indicated two later-maturating anterior tracts were negatively affected. The findings reaffirm the importance of iron for normal brain development. Given that brain differences were still evident even after iron treatment and following recovery of iron-dependent hematological indices, the results highlight the importance of early detection and preemptive supplementation to limit the neural consequences of ID. (shrink)

In 1880, Galton carried out an investigation of imagery in a sample of distinguished men and a sample of nonscientists (adolescent male students). He concluded that scientists were either totally lacking in visual imagery or had “feeble” powers of mental imagery. This finding has been widely accepted in the secondary literature in psychology. A replication of Galton’s study with modern scientists and modern university undergraduates found no scientists totally lacking in visual imagery and very few with feeble visual imagery. Examination (...) of Galton’s published data shows that his own published data do not support his claims about deficient visual imagery in scientists. The modern data for scientists and nonscientists and the 1880 data for scientists and nonscientists are in agreement in showing that all groups report substantial imagery on recollective memory tasks such as Galton’s breakfast questionnaire. We conclude that Galton’s conclusions were an example of theory-laden interpretation of data based on the initial responses from several very salient scientists who reported little or no visual imagery on Galton’s imagery questionnaire. (shrink)

L’article propose une lecture groupale, centrée sur la famille, des comportements d’hétéro-agressivité dans la clinique de l’autisme et de la déficience intellectuelle sévère et présente l’intérêt de l’articulation de dispositifs groupaux thérapeutiques. Pour cela, l’auteure met au travail une situation clinique familiale. Elle aborde l’actualisation des dépôts d’un espace à l’autre, les enjeux d’historicisation grâce à une écoute polyphonique et au redoublement d’emboîtement. Enfin, elle montre comment les comportements d’hétéro-agressivité se manifestent comme travail psychique de la pulsion de mort au (...) sein de la famille. (shrink)

Contemporary treatments of humility typically treat humility as a virtue that is reserved for the accomplished. I argue that paradigmatic humility can also be possessed by the deficient, and I provide an extended example of such humility. I further argue that attending to such a case helps us to appreciate the way in which the humble have released both the desire for superiority and the aversion to inferiority. Accordingly, when necessary, the humble will exhibit an extremely low concern with (...) their own status relative to that of others. (shrink)

Historically, there has been great deliberation about the limits of human knowledge. Isaac Newton, recognizing his own shortcomings, once described himself as “a boy standing on the seashore... whilst the great ocean of truth lay all underscored before me.” In _Ignorance,_ Nicholas Rescher presents a broad-ranging study that examines the manifestations, consequences, and occasional benefits of ignorance in areas of philosophy, scientific endeavor, and ordinary life. Citing philosophers, theologians, and scientists from Socrates to Steven Hawking, Rescher seeks to uncover the (...) factors that hinder our cognition. Rescher categorizes ignorance as ontologically grounded, or epistemically grounded. He then defines the basis of ignorance: inaccessible data; statistical fogs; secreted information; past data that have left no trace; future discoveries; future contingencies; vagrant predicates; and superior intelligences. Such impediments set limits to inquiry and mean that while we can always extend our existing knowledge-variability here is infinite-there are things that we will never know. Cognitive finitude also hinders our ability to assimilate more than a certain number of facts. We may acquire additional information, but lack the facility to interpret it. More information does not always increase knowledge; it may point us further down the path toward an erroneous conclusion. In light of these deficiencies, Rescher looks to the role of computers in solving problems and expanding our knowledge base, but finds limits to their reasoning capacity. As Rescher's comprehensive study concludes, ignorance itself is a fertile topic for knowledge, and recognizing the boundaries of our comprehension is where wisdom begins. (shrink)

In recent years scholars working in the area of Religious Studies have increasingly been obliged to acknowledge that the level of methodological rigour displayed in many studies on religious phenomena is unsatisfactory, perhaps particularly when compared to that of some academics operating in related subject areas. Arguably one of the principal areas in which an apparent reticence to engage with contemporary developments in method is evident is that of ‘religious ethnography’. The purpose of this short study is to assess the (...) extent to which ethnographic practices in the study of Tibetan Buddhism have historically responded to methodological developments in ethnography and anthropology, and to briefly suggest ways in which studies in this area may progress in the future. (shrink)

Deficiencies or unclear statements in consent forms used for research with human participants may lead to publicly-funded research data being unsuitable for sharing with other researchers. Long-term data use is encouraged or required by many of the UK research councils and other funding bodies. Researchers may fail to address long-term use and sharing of data when obtaining informed consent and when arranging to keep data obtained from participants confidential. Sharing data should not compromise confidentiality if care is taken to anonymize (...) information where this is needed or has been explicitly requested. Whilst researchers should consider all potential uses of their research data in confidentiality and consent agreements, research ethics committees can provide better guidance by pointing out to researchers that long-term use, preservation and sharing of research data should be taken into account when informing participants and obtaining their consent. (shrink)

The discursive production of the ‘self in the context of mental health care has potential implications for how the subjects of intervention come to understand and experience themselves. Eating disorders provide an illustrative example of the ways in which conceptualizations of the self that structure mental health practices can be gendered, because they are mainly diagnosed in women and dominant explanations of their origins are feminized. This discourse analytic study examines the gendered nature of mental health workers’ constructions of the (...) eating-disordered self through the psychological construct of ‘identity’, examining the dominant discourses implicated in the feminization of deficient identity, and addressing the implications of this construction for mental health practice. (shrink)