Background: Frailty is a common syndrome among older adults and patients with several comorbidities. Grip strength is a representative parameter of frailty because it is a valid indicator of current and long-term physical conditions in the general population and patients with severe mental illnesses. Physical and cognitive capacities of people with SMIs are usually impaired; however, their relationship with frailty or social functioning have not been studied to date. The current study aimed to determine if GS is a valid predictor (...) of changes in cognitive performance and social functioning in patients with type-2 diabetes mellitus and SMIs. Methods: Assessments of social functioning, cognitive performance, and GS were conducted in 30 outpatients with type 2 diabetes mellitus, 35 with major depressive disorder, 42 with bipolar disorder, 30 with schizophrenia, and 28 healthy controls, twice during 1-year, follow-up period. Descriptive analyses were conducted using a one-way analysis of variance for continuous variables and the chi-squared test for categorical variables. Differences between groups for the motor, cognitive, and social variables at T1 and T2 were assessed using a one-way analysis of covariance, with sex and age as co-variates. To test the predictive capacity of GS at baseline to explain the variance in cognitive performance and social functioning at T2, a linear regression analysis was performed. Results: Predictive relationships were found among GS when implicated with clinical, cognitive, and social variables. These relationships explained changes in cognitive performance after one year of follow-up; the variability percentage was 67.7%, in patients with type-2 diabetes mellitus and 89.1% in patients with schizophrenia. Baseline GS along with other variables, also predicted changes in social functioning in major depressive disorder, bipolar disorder, and schizophrenia, with variability percentages of 67.3, 36, and 59%, respectively. Conclusion: GS combined with other variables significantly predicted changes in cognitive performance and social functioning in people with SMIs or type-2 diabetes mellitus. Interventions aimed to improve the overall physical conditions of patients who have poor GS could be a therapeutic option that confers positive effects on cognitive performance and social functioning. (shrink)

Objective: Cognitive impairment is a common neurological complication in patients with end-stage renal disease undergoing maintenance hemodialysis. Brain network analysis based on graph theory is a promising tool for studying CI. Therefore, the purpose of this study was to analyze the changes of functional brain networks in patients on MHD with and without CI by using graph theory and further explore the underlying neuropathological mechanism of CI in these patients.Methods: A total of 39 patients on MHD and 25 healthy controls (...) matched for age, sex, and years of education were enrolled in the study. Resting-state functional magnetic resonance imaging and T1-weighted high-resolution anatomical data were obtained, and functional brain networks for each subject were constructed. The brain network parameters at the global and regional levels were calculated, and a one-way analysis of covariance was used to compare the differences across the three groups. The associations between the changed graph-theory parameters and cognitive function scores in patients on MHD were evaluated using Spearman correlation analysis.Results: Compared with HCs, the global parameters [sigma, gamma, and local efficiency ] in both patient groups decreased significantly. The clustering coefficient in patients with CI was significantly lower than that in the other two groups. The regional parameters were significantly lower in the right superior frontal gyrus, dorsolateral and gyrus rectus of patients with CI than those of patients without CI; however the nodal local efficiency in the left amygdala was significantly increased. The global Cp and regional parameters in the three brain regions were significantly correlated with the cognitive function scores.Conclusion: This study confirmed that the topology of the functional brain network was disrupted in patients on MHD with and without CI and the disruption of brain network was more severe in patients with CI. The abnormal brain network parameters are closely related to cognitive function in patients on MHD. (shrink)

La revolución darwiniana, lejos de ser algo ya superado, como a veces se pretende, aún no ha concluido del todo. Y no ha concluido porque todavía nos falta una adecuada explicación darwinista de uno de los aspectos fundamentales de los seres vivos. Tenemos explicaciones darwinistas de cientos, quizás de miles de rasgos adaptativos, pero aún no contamos con una explicación bien establecida del origen y desarrollo evolutivo de las capacidades cognitivas en aquellos seres vivos que las poseen, y muy en (...) particular del origen y desarrollo evolutivo de la mente humana. Este libro analiza las principales hipótesis que han elaborado los científicos al respecto e intenta obtener algunas conclusiones filosóficas relevantes a partir ellas y de los datos sobre las que se sustentan. Antonio Diéguez es catedrático de Lógica y Filosofía de la Ciencia en la Universidad de Málaga. Sus líneas principales de investigación son la epistemología evolucionista y el realismo científico. Entre sus publicaciones destacan los siguientes libros: la teoría de las ciencias morales en John Stuart Mill (1988), Realismo científico (1998) y Filosofía de la Ciencia (2005), publicado este último por Biblioteca Nueva. (shrink)

Der dritte Band der Studienausgabe enthält die beiden zentralen Vorlesungen der praktischen Philosophie Fichtes aus der späten Berliner Zeit, die Rechtslehre von 1812 und die Sittenlehre von 1812. Ihnen vorangestellt sind die >Vorlesungen über die Bestimmung des Gelehrten, die Fichte im Sommersemester 1811 gehalten hat. Aufbauend auf der Bestimmung der wissenschaftlichen und philosophischen Erkenntnis in seinen Einleitungsvorlesungen in die Philosophie (s. Band I und II), zeigt Fichte hier, was das Wesen des Wissenschaftlers bzw. des Gelehrten ausmacht, seine spezifische Aufgabe und (...) seine sittliche Verantwortung in der Welt. - Fichtes Rechtslehre wird streng nach der Handschrift ohne weitergehende Ergänzungen wiedergegeben; so lassen sich die Unterschiede zur Grundlage des Naturrechts von 1796 bei aller Strukturähnlichkeit deutlich erkennen. - Ganz im Sinne der späten Wissenschaftslehre als Lehre der Erscheinung des Absoluten geht die Sittenlehre 1812 von einem höchsten Grundsatz aus, dem absoluten Bilden, das als oberstes Ideal, in Fichtes Terminologie als Begriff, erscheint. Die Analyse des Satzes Der Begriff sey Grund der Welt. (shrink)