European writer of Romanian origin, Vintila Horia - Goncourt Prize in 1960 for the novel Dieu est né enexil - was a truly awakened consciousness of his time. Wherever he was - in Bucharest or Florence, Buenos Aires or Paris, Rome or Madrid - this “polyglot nomad” never left the unyielding values of the spirit and of knowledge. His work of literary epistemology, hisnovelistic creation - fed by exile, love and by the divine -, as well as the Journal d’un (...) paysan du Danube, stand as testimony. Focal point of my approach, this text sheds light on the metaphysical realm of a way of thinking in which the undivided man and the man to come are one and the same. Since for the exiled VintilaHoria,”the peasant from the Danube” is “celui dans lequel ce qui fut rencontre celui qui sera, dans un espace-temps non-euclidien”, and his journal emphasizes this “rediscovery”, in spite of the dark times of history; an encounter in, through and beyond the broken grounds of science, art and philosophy, but nevertheless, deeply anchored in philosophy, art and science. Apparently, rediscovery and isolation of the same proportion; in fact, we are talking about an anagnorisis: the inner man and the outer man have never separated, despite the “microbial fauna of Kali Yuga”. “Nomade polyglotte” through his evolution, a result of flawless reflexive stability, Vintila Horia proves himself to be, at the same time, animmobile nomad; “the peasant from the Danube” is the plenary expression of this unusual simultaneity. (shrink)

Cet article étudie la doctrine aristotélicienne du moteur immobile, cause de tout mouvement et de tout savoir, cause efficiente et cause finale, que l'A. assimile à Dieu.

Short-term limb immobilization results in skeletal muscle decline, but the underlying mechanisms are incompletely understood. This study aimed to determine the neurophysiologic basis of immobilization-induced skeletal muscle decline, and whether repetitive Transcranial Magnetic Stimulation could prevent any decline. Twenty-four healthy young males underwent unilateral limb immobilization for 72 h. Subjects were randomized between daily rTMS using six 20 Hz pulse trains of 1.5 s duration with a 60 s inter-train-interval delivered at 90% resting Motor Threshold, or Sham (...) rTMS throughout immobilization. Maximal grip strength, EMG activity, arm volume, and composition were determined at 0 and 72 h. Motor Evoked Potentials were determined daily throughout immobilization to index motor excitability. Immobilization induced a significant reduction in motor excitability across time. The rTMS intervention increased motor excitability at 0 h. Despite daily rTMS treatment, there was still a significant reduction in motor excitability, loss in EMG activity, and a loss of maximal grip strength after immobilization. Interestingly, the increase in biceps and posterior forearm skinfold thickness with immobilization in Sham treatment was not observed following rTMS treatment. Reduced MEPs drive the loss of strength with immobilization. Repetitive Transcranial Magnetic Stimulation cannot prevent this loss of strength but further investigation and optimization of neuroplasticity protocols may have therapeutic benefit. (shrink)

This is a translation of II Motore Immobile (Metafisica, libro XII), Traduzione intégrale, introduzione e commento by Giovanni Reale (Editrice La Scuola, Brescia, 4th Ed. 1971)- The author offers a unitary reading of the famous twelfth book of Aristotle's Metaphysics. The book is intended for students who wish to read the text itself of Aristotle’s, so that the introduction and commentary to the text and the summaries of the entire Metaphysics as well as the twelfth book gives the student ample (...) material to read the text intelligently. The work is aware of the current state of Aristotelian studies but does not intrude them into the commentary, because they should be reserved for more specialized work which the author has completed. (shrink)

La notion de temps occupe une place determinante dans l'oeuvre de Lucrece, alors que cet aspect a ete jusqu'alors peu explore. L'ambition de cet ouvrage est de demontrer que le temps unifie dans une vision complexe et ambivalente la physique, l'histoire, la morale et la poetique lucretiennes. Le present livre est fonde sur une etude de la fonction du temps au sein de ces differents domaines et montre comment la duree infinie qui caracterise les mouvements atomiques chez Epicure se traduit (...) pour son disciple latin par la permanence et l'invariance. Cette synthese d'ordre philosophique est soutenue par le genie poetique de Lucrece, qui parvient a reveler l'equilibre eternel, dissimule derriere le regne apparent du hasard et du desordre. L'auteur invite ainsi le lecteur de Lucrece a un parcours a la fois philosophique et poetique a travers le De rerum natura afin de decouvrir le lieu d'ou l'on contemple la permanence immobile du mouvement et l'eternite du temps. L'image de l'eclair immobile dans la plaine s'offre des lors comme un symbole fulgurant de la conception lucretienne du temps, qui concilie mouvement et repos dans la poesie. Sabine Luciani, nee en 1967, est maitre de conferences en langue et litterature latines a l'universite Paul Valery - Montpellier III. Elle est specialiste de philosophie epicurienne, a publie plusieurs articles concernant Lucrece et, plus generalement, l'influence de la philosophie hellenistique sur l'oeuvre des poetes latins. Elle poursuit actuellement des recherches sur les sources de Lucrece. (shrink)

This paper presents the results of qualitative research on academic inbreeding in Czech higher education, the first of its kind. Its focus is on exploring the significance of academic inbreeding, its types, practices, and possible solutions. The research for this paper was done among academic staff at eight institutions of higher education in the Czech Republic. It was conceptually informed by ideas about different types of inbred employees (immobile, mobile, silver-corded, and adherent) and available policy tools. The results show that (...) academic inbreeding has long flown under the radar as an issue. Its impact is perceived ambivalently, as both positive and negative, by academics and experts alike. Generally, its avoidance has not been taken into account in staff recruitment, which has allowed it to become widespread among Czech higher education institutions. The policy tools for combatting academic inbreeding include nodality (open recruitment), reorganization of recruitment procedures, capacity-building (including stays abroad), and hortatory proclamations (paying attention to the issue). Overall, the evidence gathered in the course of research suggests that some progress has been made in limiting academic inbreeding at some workplaces, and that what we would call purely immobile inbred employees are giving way to mobile and “silver-corded” inbred academic staff. Finally, Czech higher education institutions register few cases of pseudo-inbreeding, combining work at the same institution where a PhD was taken with an academically relevant position in a state research institute or the Academy of Sciences. (shrink)

Cet ouvrage montre la portée universelle de Maître Eckhart en étudiant l'influence de son oeuvre dans la phénoménologie d'Husserl et la dialectique d'Hegel, et les rapports entre la pensée de Maître Eckhart et la mystique chinoise de Laozi.

What is characteristic of being aParkinson’s patient? This article intends toanswer this question by means of an analysis ofnovels about people with Parkinson’s disease,personal accounts, and scientific publications.The texts were analyzed from anexistential-phenomenological perspective, usingan adapted version of the existential analysis.Being a Parkinson’s patient is apparentlycharacterized by an existential paradox: lifeappears simultaneously immobile andunpredictably whimsical. This may manifestitself in the person’s corporeality, in hisbeing-in-time and in-space, in his relating tothings and events, his life-world, and in hisbeing-together-with-others as an individual.Finally, some (...) specific characteristics of beinga Parkinson’s patient are described that may berelevant for purposes of adequate care, as isto be specified by further research. (shrink)

Newton's arguments for the immobility of the parts of absolute space have been claimed to licence several proposals concerning his metaphysics. This paper clarifies Newton, first distinguishing two distinct arguments. Then, it demonstrates, contrary to Nerlich ([2005]), that Newton does not appeal to the identity of indiscernibles, but rather to a view about de re representation. Additionally, DiSalle ([1994]) claims that one argument shows Newton to be an anti-substantivalist. I agree that its premises imply a denial of a kind of (...) substantivalism, but I show that they are inconsistent with Newton's core doctrine that not all motion is the relative motions of bodies, and so conclude that they are not part of his considered views on space. The Arguments The Identity Argument 2.1 Identity of indiscernibles for individuals 2.2 Identity of indiscernibles for worlds and states 2.3 Representation de re Kinematic Relationism Conclusion CiteULike Connotea Del.icio.us What's this? (shrink)

Arthrogryposis multiplex congenita (AMC) is a heterogeneous syndrome where multiple joints have reduced range of motion due to contracture formation prior to birth. A common cause of AMC is reduced embryonic movement in utero. This reduction in embryonic movement can perturb molecular mechanisms and signaling pathways involved in the formation of joints during development. The absence of mechanical stimuli can impair joint cavitation, resulting in joint fusion, and ultimately eliminate function. In turn, mechanical stimuli are critical for proper joint formation (...) during development and for mitigating AMC. Studies in experimental animal models have provided a greater understanding on the molecular pathophysiology of congenital contracture formation as a consequence of embryonic immobilization. Elucidation of how the mechanical signaling environment is transduced to initiate a biological response will be necessary to gain a deeper understanding of how mechanical stimuli are intertwined in the molecular regulation of joint development. (shrink)

Immobilized Metal‐ion Affinity Chromatography, IMAC, has been gaining in popularity as the purification technique of choice for proteins and peptides. IMAC of proteins on transition metals (Co, Ni, Cu, Zn) can be rationalized in terms of the coordination of histidine residues. Brief accounts of the principles of IMAC, its anticipated development and plausible applications are presented. Metal Ion Transfer, MIT, may offer an efficient means to deplete a metal ion from a metalloprotein or, conversely, to charge its apo form with (...) a metal. (shrink)

In _Animacies_, Mel Y. Chen draws on recent debates about sexuality, race, and affect to examine how matter that is considered insensate, immobile, or deathly animates cultural lives. Toward that end, Chen investigates the blurry division between the living and the dead, or that which is beyond the human or animal. Within the field of linguistics, animacy has been described variously as a quality of agency, awareness, mobility, sentience, or liveness. Chen turns to cognitive linguistics to stress how language habitually (...) differentiates the animate and the inanimate. Expanding this construct, Chen argues that animacy undergirds much that is pressing and indeed volatile in contemporary culture, from animal rights debates to biosecurity concerns. Chen's book is the first to bring the concept of animacy together with queer of color scholarship, critical animal studies, and disability theory. Through analyses of dehumanizing insults, the meanings of queerness, animal protagonists in recent Asian/American art and film, the lead in toys panic in 2007, and the social lives of environmental illness, _Animacies_ illuminates a hierarchical politics infused by race, sexuality, and ability. In this groundbreaking book, Chen rethinks the criteria governing agency and receptivity, health and toxicity, productivity and stillness—and demonstrates how attention to the affective charge of matter challenges commonsense orderings of the world. (shrink)

Plants are commonly considered immobile, in contrast to humans and other animals. But vegetal existence involves many place-based forms of change: stems growing upward, roots spreading outward, fronds unfurling in response to sunlight, seeds traveling across wide distances, and other intricate relationships with the surrounding world. How do plants as sessile, growing, decaying, and metamorphosing beings shape the places they inhabit, and how are they shaped by them? How do human places interact with those of plants-in lived experience; in landscape (...) painting; in cultivation and contemplation; in forests, fields, gardens, and cities? Examining these questions and many more, Plants in Place is a collaborative study of vegetal phenomenology at the intersection of Edward S. Casey's phenomenology of place and Michael Marder's plant-thinking. It focuses on both the microlevel of the dynamic constitution of plant edges or a child's engagement with moss and the macrolevel of habitats that include the sociality of trees. This compelling portrait of plants and their places provides readers with new ways to appreciate the complexity and vitality of vegetal life. Eloquent, descriptively rich, and insightful, the book also shows how the worlds of plants can enhance our understanding and experience of place more broadly. (shrink)

Interdisciplinary work on the nature of borders and society has enriched and complicated our understanding of democracy, community, distributive justice, and migration. It reveals the cognitive bias of methodological nationalism, which has distorted normative political thought on these topics, uncritically and often unconsciously adapting and reifying state‐centered conceptions of territory, space, and community. Under methodological nationalism, state territories demarcate the boundaries of the political; society is conceived as composed of immobile, culturally homogenous citizens, each belonging to one and only one (...) state; and the distribution of goods is analyzed according to a stark opposition between the domestic and the international. This article describes how methodological nationalism has shaped central debates in political philosophy and introduces recent work that helps dispel this bias. (shrink)

Il faudrait que le dialogue se fasse, non pas entre des personnes, mais entre les lignes, entre des chapitres ou des parties de chapitre. Ce seraient les vrais personnages. Perdre la mémoire : il faudrait plutôt dresser des " blocs ", les faire flotter. Un bloc d'enfance n'est pas un souvenir d'enfant. Un bloc nous accompagne, est toujours anonyme et contemporain, et fonctionne dans le présent - Oublier l'histoire : la question des devenirs, et de leur géographie. Un devenir-révolutionnaire est (...) plus important que l'avenir ou le passé de la révolution. Un devenir-femme, un devenir-animal sont plus importants que la différence des sexes et des règnes - Ne pas " faire le point " : plutôt tracer des lignes. Les lignes n'ont pas d'origine, et poussent par le milieu. On ne fait jamais table rase, on est toujours au milieu de quelque chose, comme l'herbe. Plus on prend le monde là où il est, plus on a de chance de le changer... Se séparer de l'appareil d'Etat et de tout système qui le prend pour modèle ou veut le conquérir : la présence diffuse de machines de guerre irréductibles au modèle d'Etat, toute une histoire populaire qui n'a pas été recueillie, un nomadisme même immobile. Devenir ou re-devenir marxiste : aucune analyse n'est possible si elle ne porte aussi sur les mécanismes industriels et surtout financiers dans un champ social. Non pas suprême instance, mais lignes, et régimes de signes, qui s'enchaînent avec les autres, et dont les flottaisons s'agencent avec d'autres flux. (shrink)

These substances have been considered in recent times, as in traditional interpretation, to be identical with the immobile Movers of the Physics. Both Physics and Metaphysics refer to the same separate substances. On the other hand, the immobile Movers of the Physics have been identified with the immanent souls of the Heavens, and so sharply distinguished from the separate substances of the Metaphysics. Then in the opposite extreme, the Movers of the Metaphysics have been completely identified with the celestial souls. (...) Or again, the first only of the Movers has been declared separate, and the others identified with the different sphere-souls, among which is the first Mover of the Physics. In still another interpretation the first Mover alone is separate, but the other immobile Movers are held to be the divine thoughts, identical with the first Mover. Even the first Mover has been interpreted as a thought in the mind of some other Being, as merely an ideal or standard of goodness which does not imply--though it need not exclude--any corresponding existent reality in the Aristotelian universe. (shrink)

The metaphor of scaffolding has become current in discussions of the cognitive help we get from artefacts, environmental affordances and each other. Consideration of mathematical tools and representations indicates that in these cases at least, scaffolding is the wrong picture, because scaffolding in good order is immobile, temporary and crude. Mathematical representations can be manipulated, are not temporary structures to aid development, and are refined. Reflection on examples from elementary algebra indicates that Menary is on the right track with his (...) ‘enculturation’ view of mathematical cognition. Moreover, these examples allow us to elaborate his remarks on the uniqueness of mathematical representations and their role in the emergence of new thoughts. (shrink)

In this paper we critically examine mobile markets as an emerging approach to serving communities with limited healthy food options. Mobile markets are essentially farm stands on wheels, bringing fresh fruits, vegetables and other food staples into neighborhoods, especially those lacking traditional, full service grocery stores, or where a significant proportion of the population lacks transportation to grocery stores. We first trace the emergence of contemporary mobile markets, including a brief summary about how and where they operate, what they aim (...) to achieve, who they serve, and the general constraints on their operations. We then report case study findings that examine the operational benefits and challenges of two mobile markets operating in Syracuse, New York. Our research suggests that although Syracuse’s mobile markets play a positive role in alleviating geographic, economic and social barriers to fresh food access experienced by elderly, immobile and low income residents living in Syracuse’s urban neighborhoods, the impacts of the mobile markets are dampened by both operational constraints and larger political and economic forces. (shrink)

Il est relativement peu de textes qui, dans le De Cœlo, témoignent de l’existence de réalités incorporelles transcendantes à l’ordre astral. La conclusion, sur laquelle se referme la démonstration de l’unicité du ciel en I 9, est-elle de ceux‑là? Les « êtres de là-bas » y désignent-ils les réalités sidérales les plus hautes ou certaines instances hypercosmiques? C’est à l’identification de ces êtres qu’il s’agit ici de procéder. En montrant que convergent ensemble les indices textuels du passage et son homogénéité (...) démonstrative, il pourra alors apparaître que ces êtres, dont Aristote vante l’immutabilité et la perfection, transcendent l’ordre céleste, sans qu’on puisse toutefois déterminer la relation exacte qui les unit au ciel, obérant ainsi la possibilité de lire, à travers eux, une référence implicite à la doctrine du Premier Moteur Immobile. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:129 Collisions at the Crossroads: How Place and Mobility Make Race BY GENEVIEVE CARPIO Oakland, California: University of California Press, 2019 REVIEWED BY JARED FRIESEN In Collisions at the Crossroads: How Place and Mobility Make Race, Professor of Chicana and Chicano Studies Genevieve Carpio systematically uncovers several of the insidious forms that power takes in order to construct racial inequality. Settlement, mobility, and immobility have served to draw distinctions (...) between Latino/a, Indigenous, Asian, African Americans and white populations in the inland Southern California region. Carpio produced abundant evidence to bolster these statements through interdisciplinary methodological practices, such as “reinterpreting and recovering history” through archival research, analysis of oral history projects, and the examination of both photographic records and the built environment (14). Collisions at the Crossroads begins with a recent example of how mobility and the social construction of place, or “place making” were used to exclude Latino/a residents from participating in the celebration of the Route 66 heritage of the area. In an effort to protect the authenticity of the event, organizers of the Rendezvous festival implemented a ban on lowriders, thus sanitizing the event of Mexican cruising culture that has been a part of the complex multiracial history of the region. This moment is only one of the latest in the history of inland Southern California reaching back to the arrival of white migrants in the form of the Riverside colony to a region composed of Indigenous and Mexican Book Reviews ENVIRONMENT, SPACE, PLACE / VOLUME 13 / ISSUE 2 / 2021 130 American communities. The book lays bare how “the concept of mobility particularly applies to the everyday channels of movement in a community, especially for Indigenous people and people of color” (3–­4). Mobility is conceptualized as physical movement, the shared meaning of the physical movement, and the policies that enable or constrict movement.Throughthisanalyticlens,Carpio tracesthe “Anglo Fantasy Past” to illuminate how white populations created history that places them at the center and either erases non-­white populations or reduces themtoperpetualoutsiders.Thishistoryincludeswhitesettlement,the rise of the citrus industry, and the role of religion. For example, Indigenous people were immobilized in off-­ reservation boarding schools for AmericanIndianchildren,andcapitalist-­orientedpolicieswereenacted such as the Geary Act (1892) in order to control the mobility of Chinese immigrants. The latter is an excellent example of how race continually shaped the experiences of nonwhite migrants. Mobility is encouraged when a source of low cost labor is needed, but then controlled or even criminalized in order to maintain a racialized hierarchy. Throughout the book, Carpio reinforces the precarious situation of mobilityforpeopleofcolor.“Workersweresupposedtomoveinparticu­ lar ways, at specific times, in and to predetermined spaces” (66). This was deftly accomplished in a way that expresses the subtle processes through which power is used, indeed in ways that appear normative and even natural. Without globalized labor migration, the rise of industries such as large-­ scale citrus agriculture would not have been possible. Alternatively, deterring regional labor migration and desegregated housing were critical to maintaining the white supremacist status quo. Collisions at the Crossroads connects readers to the current turmoil and fear around immigration and racism by looking back at the exploita­ tive incentivizing and coercion of Mexican migrant workers. Mexican immigrants are attracted to work in agricultural communities, then their mobility is pathologized to limit movement through public policy. Ultimately, Mexican immigrants are constructed as “birds of passage” who prefer not to be rooted to a place. Geographer Doreen Massey refers to these processes as “differentiated mobility”: “some people are more in charge of it than others; some initiate flows and movement, others don’t; some are more on the receiving-­end of it than others; some are effectively imprisoned by it.”1 Book Reviews 131 This racialization of labor created a low-­ cost workforce that was immobilized by the threat of arrest but later seen as preferable to Puerto Rican or Filipino migrants who had rights to permanent settlement. The claim was that because Mexicans preferred to migrate to worksites, they should therefore return to Mexico in the ebbs of citrus production in the inland Southern California region. Mexican migrants were considered a natural option for filling the workforce needs of the local citrus industry while... (shrink)

Un modèle pour artiste, valide du XIIIe siècle aux XVIe-XVIIe siècle, veut que la mariée, quelle qu’elle soit, soit systématiquement représentée, au banquet du mariage, immobile, yeux baissées, les mains croisées dans son giron, bouche close, alors que tous discutent et consomment autour d’elle. Quelle réalité recouvre ce topos? Chaque image du mariage est une leçon et un avertissement donnés au deuxième sexe.

Jakob von Uexküll’s problematic is manifested in his paradoxical portraiture of form within the plan of nature: the one a sensual schema and the other a transsensual ideal form. At first sight, Uexküll’s belief in the Platonic and the Reformational notions of the immobile becoming of form seems to be a resignation from the heated debates among his contemporary materialists, vitalists, dynamists, and evolutionists. However, in terms of the Kantian subjective teleology, Uexküll’s appropriation of the ancient philosophy reinstates the invisible, (...) static, but repetitive cycle as his regulating principle in the observation of the activity of animals. This regulating principle distinguishes itself from the rule of resemblance established by the appearances and fossil remains of animals, which is linear, incomplete, and digressive. In the light of Michel Foucault, the transition from the visible to the invisible recoups the study of nature from the living beings (les êtres vivants) to the life itself (la vie), from natural philosophy to biology. My study suggests that we recast Uexküll’s sign theory from his observations on the crux that models and triggers an animal to action in its Umwelt. Bracketing Uexküll’s transcendental configuration of form and image, we still find that schema, in itssensual and functional context, evolves from a reflection of the objects to a summary of their features plus an ignorance of their proper names. Uexküll's erasure of proper names (in different languages) that directs our attention to the presentation in its pure form (Gestalt) not only constitutes an important step in epistemology, but also in a life science that meticulously delves into the genotypes. (shrink)

DI.1 On everything that lives, if one looks searchingly, is limned the shadow line of an idea – an idea, dead or living, sometimes stronger when dead, with rigid, unswerving lines that mark the living embodiment with the stern immobile cast of the non living. Daily we move among these unyielding shadows, less pierceable, more enduring than granite, with the blackness of ages in them, dominating living, changing bodies, with dead, unchanging souls. And we meet, also, living souls dominating dying (...) bodies – living ideas regnant over decay and death. Do not imagine that I speak of human life alone. The stamp of persistent or of shifting Will is visible in the grass blade rooted in its clod of earth, as in the gossamer web of being that floats and swims far over our heads in the free world of air. DI.2 Regnant ideas, everywhere! Did you ever see a dead vine bloom? I have seen it. Last summer I trained some morning glory vines up over a second story balcony; and every day they blew and curled in the wind, their white, purple dashed faces winking at the sun, radiant with climbing life. Higher every day the green heads crept, carrying their train of spreading fans waving before the sun seeking blossoms. Then all at once some mischance happened, some cutworm or some mischievous child tore one vine off below, the finest and most ambitious one, of course. In a few hours the leaves hung limp, the sappy stem wilted and began to wither; in a day it was dead, – all but the top which still clung longingly to its support, with bright head lifted. I mourned a little for the buds that could never open now, and tied that proud vine whose work in the world was lost. But the next night there was a storm, a heavy, driving storm, with beating rain and blinding lightning. I rose to watch the flashes, and lo! the wonder of the world! In the blackness of the mid NIGHT, in the fury of wind and rain, the dead vine had flowered. Five white, moon faced blossoms blew gaily round the skeleton vine, shining back triumphant at the red lightning. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:An Encounter with the Art and Science of MedicineAnonymous Five“Let Nothing Upset YouLet Nothing Frighten YouEverything is ChangingOnly God is Changeless”—St. Theresa of AvilaSt. Teresa’s prayer is on the front cover of each of four binders dedicated to storing insurance authorizations, studies, references, and reports about our daughter’s brain tumor treatment. They represent our experience, what we learned, the information we were given, and the information we sought out. (...) I kept them in case our daughter ever wanted to understand how my husband and I arrived at a decision for her treatment that was in direct opposition to the strong recommendation of her primary treatment team of physicians.On December 10, 2003, I received an urgent call from our daughter’s neurologist requesting that we meet with the doctor late that afternoon. For six months prior to that appointment, our daughter had been telling us about odd sensations with breathing, nausea, and balance. Sometimes she would seem extremely distressed for a short period of time or report that her friends told her about doing or saying things that didn’t make sense and that she didn’t remember. We consulted a series of physicians as her symptoms became steadily more intense and more prevalent. Our family practice physician referred us to an allergy specialist and a pulmonologist. There were a number of tests for allergies and lung problems. As the tests and treatments did not help, our daughter became increasingly unwilling to go to doctor’s appointments. My husband and I were confused and deeply concerned about the lack of progress. The next series of referrals included a gastroenterologist and a neurologist. The gastroenterologist suggested our daughter had partial–complex epilepsy, concurred with our plan to see a neurologist, and mentioned she should have an MRI.I remember the neurologist putting the MRI scans up, pointing to the large dark spot which he called a “large mass” (5 cm), that could be either a cluster of blood vessels or a neoplasm. He said his office had arranged for us to meet a neurosurgeon the following day. We all remember the same thing about that visit—the image of the large dark mass on the scan—and the neurologists flat, brisk tone. We met with the neuro-surgeon the next day. Her team was kind and sympathetic—she was positive, up beat and direct. She did not think this mass was blood vessels. She thought it was a large tumor that needed to be removed right away. Our daughters surgery was scheduled for the following Friday—December 19, 2003. She had turned 15 on November 5.Four and a half hours after our daughter was wheeled into the operating room, her surgeon told us they had removed 98% of the tumor. She said there was no cure, but there was a good prognosis based on the surgical outcome. Several days later, she called us and said she had more data, and it looked like the resection was closer to 90%. The first pathology report, a “first impression” directly after surgery, described our daughter’s tumor as an astrocytoma, probably high grade. Three weeks after surgery, we met with a panel of doctors—two oncologists and radiologist—who explained that based on the final pathology report, our daughter’s tumor was classified as an ependymoma, grade 2. We were dismayed. First, there had been the change in the estimated success of the resection and now a complete shift in both grade and tumor type.The team recommended radiation to follow her surgery, which they said was standard treatment. We began to try to inform ourselves about her tumor. Her father, an agronomist, did an extensive search in PubMed to evaluate and sort through the literature on low–grade gliomas and radiation. What he could find was inconclusive and grim. Most reports in the literature suggested at best delayed mortality at five years after radiation. [End Page E7] Meanwhile, our daughter went through a spinal MRI and the preparatory “fitting” of the mask to immobilize her head during radiation.E7I consulted with a friend who had worked as an EKG tech. She urged... (shrink)

The preparation of samples for gene diagnosis is time‐consuming, labor‐intensive and costly. These problems can be overcome by dissolving a biological source in a strong solution of a chaotropic salt, then filtering the solution through an immobilizing membrane. Conditions exist for causing the selective immobilization of either DNA or mRNA. The resultant membrane is immediately ready for reaction with labeled gene probes.

Insofar as the purpose of modern law is to secure the freedom of the individual, meaning that modern law is thus a right of freedom, the question arises as to how this right of freedom relates to fear. The article first refers to the narrative of religion as a regime of fear, which is historically related to the narrative of peace through law. After analysing the religious technique of increasing and escalating the irrational and derailing moment of fear, it contrasts (...) the religious regime of fear with the modern regime of fear in the form of law and interprets the latter as an order of immunization against fear, i.e., as a technique of securing domination by ‘taking in the hostile other’ at the price of its division. In this perspective, law appears as a secularized version of the religiously driven escalation of fear; within the framework of a secular order of immanence it seeks to immobilize the relationship to the indeterminate and extraordinary as cultivated by fear in its abysmal nature. Consequently, fear returns to the realm of religion and superstition assigned to it in enlightened modernity. But, disturbingly, in pandemic society it continues to haunt the belief in the reality-assuring power of the normative legal order in the form of the intensifying fear of the ‘enemy in the body’. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Misquotations from RealityAnn Lauterbach (bio)In the girdle of Aphrodite, in the crown, in the body of Helen and her phantom, beauty is superimposed over necessity, cloaking it in deceit. The necessary has a certain splendor, and behind any splendor one senses a metallic coldness, as though of a weapon poised to strike. The real split in Greek consciousness, like all other irreversible steps it took, comes when Plato for (...) the first time affirms, ‘How very different is the nature of the necessary from the nature of the good.’ And he means an immense, an unbridgeable distance—the same distance that made atheists of ‘those who study astronomy and other sciences of the necessary, when they see that what is, is so out of necessity and not out of any plan conceived by some will to accomplish the good.’ The Beautiful, in this scenario, must either be quickly reabsorbed into the Good—as its agent, instrument, and pedagogue—or left up in the air, like a malignant spell (goeteuma) bewitching the mind only to subject it even more helplessly to the fiat of necessity.—Roberto Calasso, The Marriage of Cadmus and Harmonyl. The Stranger’s HandOnce at the circus, when I was young we were strolling around in a throng of clowns and cotton candy, bright sun, I looked up to find that the hand I was holding was that of a stranger.Just before dawn, ejected from sleep, I am unraveled into another condition.The place between these two conditions is complex and difficult, a peculiar suspension between two exclusive frames for which there is no dialogue box. The familiar crosses into the unfamiliar and back again.What separates works of art from the fallible empirical world is not their higher degree of perfection but their ability to actualize themselves in a brilliant and expressive appearance just like fireworks. 1Fireworks! Temporality construed as ephemeral vision.And so: In every work of art something appears that does not exist. 2And so: The question of the truth of art comes into view when a non-existent is seen to rise as if it were real. In terms of its form, art promises what is not real. Objectively, it raises the claim, however obliquely this may come out, that just because something appears, it [End Page 143] must be possible to imbue it with being. The unquenchable longing excited by the beautiful is the longing for the fulfillment of a promise. 3The promise of meaning.One of my students writes, “We deem beautiful that which offers meaning to our meaningless lives.”I failed to draw a map and you followed it perfectly because the word for ‘cannot’ inscribes itself here to define an atmosphere of absolute trust which both fastens and unfastens us. 4Day unblooms into insatiable prerogatives vetoedsustained in their august sudden ramifications as if saying soEvery frame is danger and security. Poems that interest me are poems that show me how to proceed, not where to go or what to look at. They assuage the panic of the Stranger’s Hand by awakening curiosity rather than fear. The poem attests to the mobility of the frame, not to the totality of the picture.Thus the grip of realism has found a picture chosen to cover the space occupied by another picture establishing a flexibility so we are not immobile like a car that spends its night outside a window, but mobile like a spirit. 5* * * but we were not, we are not shadows; as we walk, heel and sole leave our sandal-prints in the sand, though the wounded heel treads lightly and more lightly follow, the purple sandals. 6 [End Page 144]2. The Real ThingA poet too has constantly to ask himself: “but is what I am writing really true?”—and this does not necessarily mean: “Is this how it happens in reality?” 7I do not remember when or why I became interested in looking at the ways in which notions of the truth and notions of the real had become blurred. Perhaps in the slogans of advertising. Perhaps it was the political discourse around the Vietnam... (shrink)

The developing neuromuscular junction has provided an important paradigm for studying synapse formation. An outstanding feature of neuromuscular differentiation is the aggregation of acetylcholine receptors (AChRs) at high density in the postsynaptic membrane. While AChR aggregation is generally believed to be induced by the nerve, the mechanisms underlying aggregation remain to be clarified. A 43‐kD protein (43k) normally associated with the cytoplasmic aspect of AChR clusters has long been suspected of immobilizing AChRs by linking them to the cytoskeleton. In recent (...) studies, the AChR clustering activity of 43k has, at last, been demonstrated by expressing recombinant AChR and 43k in non‐muscle cells. Mutagenesis of 43k has revealed distinct domains within the primary structure which may be responsible for plasma membrane targeting and AChR binding. Other lines of study have provided clues as to how nerve‐derived (extracellular) AChR‐cluster inducing factors such as agrin might activate 43k‐driven postsynaptic membrane specialization. (shrink)

È opinione oggi largamente diffusa che la visione storica e politica di Dante abbia caratteri fortemente conservatori o addirittura reazionari. In sintesi, la polemica dantesca contro lʼavarizia e la cupidigia nasconderebbe un radicale rifiuto della modernità e della nuova realtà socioeconomica che si stavano affermando ai suoi tempi, in nome di un ritorno al «buon tempo antico» e al mondo immobile e chiuso della tradizione. In questo saggio intendo dimostrare, al contrario, che lʼipotesi elaborata da Dante è tuttʼaltro che conservatrice, (...) ma propone invece un modello rivoluzionario di società fondata sui valori del dono e della caritas opposti allʼutilitarismo che fino da allora si stava imponendo come principio guida della civiltà occidentale. (shrink)