The traditional researcher-driven environment of medical knowledge production is losing its dominance with the expansion of, for instance, community-based participatory or participant-led medical research. Over the past few decades, sociologists of science have debated a shift in the production of knowledge from traditional discipline-based to more socially embedded and transdisciplinary frameworks. Recently, scholars have tried to show the relevance of Mode 2 knowledge production to medical research. However, the existing literature lacks detailed clarifications on how a model of (...) class='Hi'>Mode 2 knowledge production can be constructed in the context of medical research. This paper calls for such further clarifications. As a heuristic means, the advocacy for a controversial experimental stem cell therapy is examined. It is discussed that the example cannot be considered a step towards Mode 2 medical knowledge production. Nonetheless, the example brings to the fore some complexities of medical knowledge production that need to be further examined including: the shifting landscape of defining and addressing vulnerability of research participants, the emerging overlap between research and practice, and public health implications of revising the standard notions of quality control and accountability. (shrink)

The author's initial assumption is that in the eyes of much of the younger generation of artists, curators, art critics, and even philosophers, aesthetics has lost its potential to say essential or meaningful truths about contemporary art. Since their beginnings in the eighteenth century, both art and aesthetics have drawn their import from the division between the aesthetic and the practical. The work of Kant generated a tradition which was decisive for our understanding of aesthetics. For this tradition the central (...) issue was the autonomy of art (or, later, the autonomy of culture). It has now become clear that both art and culture have gradually lost their autonomy, and that consequently aesthetics as a discipline lost its former significance. It is, however, important to realise that if society has changed, then not only art and aesthetics, but also other fields and disciplines have had to respond to this change. Due to the fact that for the most part the co-evolution of society and science is responsible for the change that we are witnessing, the author focuses on changes in the contemporary production of knowledge in order to understand this change, in the hope that it could be enlightening to aesthetics as well. He proceeds to the close reading of the theory of scientific knowledge production developed by Michael Gibbons et al, termed Mode-2. In the final part of the article the relation between knowledge production and art/culture is established, showing that aesthetics needs transgress its disciplinary borders in order to survive. (shrink)

This paper investigates the impact of changing science policy doctrines on the development of an academic field, working life research. Working life research is an interdisciplinary field of study in which researchers and stakeholders collaborated to produce relevant knowledge. The development of the field, we argue, was both facilitated and justified by the, at the time dominant, science policy orthodoxy in Sweden, sector research. Sector research science policy doctrine favoured stakeholder-driven research agendas in the fields relevant to the sector. This (...) approach to agenda setting was highly contested by Swedish universities and left scientists vulnerable to the fallout from any conflicts arising among the stakeholder groupings that were part of the governance arrangement. Our case shows that working life research was in part a victim of the struggle between science and policy over who sets the agenda for science in Sweden. In this struggle, each side chose to use ‘scientific quality’ as a proxy for furth ing its respective interests and visions for how science should be governed. The paper argues that this case is of interest to the continued elaboration of the Mode 2 thesis and the debate about ‘relevant science’. We find that the close association with stakeholders and the concomitant dependence it created left working life research unable to defend itself against its critics and that this state of affairs was particularly problematic for social science research on working life. (shrink)

The New York Times receives more citations from academic journals than the American Sociological Review, Research Policy, or the Harvard Law Review. This article explores the reasons why scholars cite the NYT so much. Reasons include studying the newspaper itself or New York City, establishing public interest in a topic by referencing press coverage, introducing specificity, and treating the NYT very much like an academic journal. The phenomenon seems to reflect a mode 2 type of scholarship produced in the (...) context of application, organizationally diverse, socially accountable, and aiming to be socially useful as well as high quality as assessed by peers. (shrink)

Growing expectation that research addresses problems in the context of application has spurred theorization about a ‘‘new mode’’ of production, Mode 2, which contrasts with Mode 1 or discipline-based research production in terms of animating questions, organization, and evaluation criteria. This article examines how the proposed Mode 2 form of research production and the practical role of the intellectual that it promotes align with the career trajectories and identities of academics who simultaneously engage in Mode (...) 1 work. It focuses on a setting that is particularly susceptible to global shifts in knowledge production: a developing country and longtime object of external intervention, Malawi. Numerous contradictions are found between Mode 1 and 2 production as well as impediments to the conversion of products generated in Mode 2 into scholarly contributions to Mode 1 development. The evidence draws from 42 interviews conducted with academics and independent researchers in Malawi during 2003 and 2004 as well as historical documents. (shrink)

Thesis (Ph.D.)-University of Natal, Durban, 2002.

본 논문은 『수사학』 2권에 나타난 감정에 관한 정의(definition)가 가지는 역할과 양상에 관한 연구이다. 이러한 연구는 파토스적 설득의 실현 기반이 되는 감정의 인지성의 측면에서 진행되었다. 감정에 있어서의 인지주의는 감정을 감정으로 만드는 ‘본질적 요소가 무엇인가’라는 물음에 믿음(belief)이나 판단(judgement) 등의 사고적인 부분, 즉 인지적 요소로 답하는 것이다. 때문에 어떠한 사실에 대하여 가지게 되는 판단과 믿음이라는 사고의 영역은 느낌과 욕구보다 더 근본적이며, 판단과 믿음의 차이는 서로 다른 감정의 차이를 구별하는 기준이 된다. 아리스토텔레스는 『수사학』 2권에서 성격(ēthos), 감정(pathos), 논증(logos)을 통해 상대방을 설득하는 것을 목표로 연설 상황에서 (...) 일으켜야 할 감정들을 분석하고 있다. 그의 분석은 인지주의적 입장을 피력하는 것에 초점을 두지는 않았다. 그러나 아리스토텔레스의 감정에 대한 정의(definition) 부분은 그의 인지주의적 입장을 2가지 양상으로 분명히 드러내고 있다. 첫째는 원인 · 이유를 보여주는 양상이다. 아리스토텔레스는 감정에 대한 정의에서 각 감정들이 일어나는 ‘원인 · 이유’를 명시하거나 유추 가능하도록 서술함으로써 각 감정들의 인지적 요소를 상정하고 있다. 둘째는 감정을 개별화하는 양상이다. 아리스토텔레스의 정의는 감정의 ‘본질’을 규정함으로써 감정들 사이의 차이를 드러내고, 각 감정들을 개별화하게 된다. 결국 그의 정의는 감정의 인지성을 바탕으로 현대 연구자들이 문제시되는 감정의 본질을 검토하며, 각 감정들을 개별화하도록 하는 기초가 되었다. 결론적으로 감정에 대한 정의는 원인 · 이유를 보여주며, 감정을 개별화하는 2가지 양상으로 아리스토텔레스의 인지주의적 견해를 입증하고 있는 것이다. (shrink)

This paper examines some aspects of Spinoza's metaphysics of the essences of modes.2 I situate Spinoza's use of the notion of essence as a response to traditional, Aristotelian, ways of thinking about essence. I argue that, although Spinoza rejects part of the Aristotelian conception of essence, according to which it is in virtue of its essence that a thing is a member of a kind, he nevertheless retains a different part of such a conception, according to which an essence is (...) some structural feature of a thing which causally explains other, non-essential features. I go on to develop an account of Spinoza's metaphysics of essence, according to which essences, what he sometimes calls formal essences, are produced by the divine essence prior to and independent of the creation of finite modes, and according to which essences are the formal or exemplar causes of finite modes. I then argue that finite modes, in virtue of the formal essences which they actualize, are genuine causal relata. Finally, I offer some speculations about Spinoza's answer to the question, "Why, in a necessitarian cosmos filled with formal essences, should there be temporal finite modes at all?". (shrink)

This paper takes up some threads of Deleuze’s and Ruyer’s engagement with biology. I begin by laying out the main features of Deleuze’s scheme of morphogenesis, through the lens of his references to embryology. I take Deleuze’s interest in embryology to be guided by the effort to define bodies solely by form-generating factors which are immanent to them. His concept of virtuality, which indicates the creative component of reality, the open field of connections defining a body’s capacities for transformation and (...) interaction, plays a key role in this regard. I then consider two implications: (1) The insistence on morphogenesis displaces the question of life from given biological entities, which preserve themselves and act through regulated cycles, to the myriad of activities that compose and modify them; (2) It also rearticulates the distinction between the living and the nonliving, in that it separates the question of life from that of its emergence from a given material arrangement. In the second part I examine these points with greater reference to Ruyer. After introducing Ruyer’s concepts of functioning and formation, I focus on his account of the continuity between biological and physicochemical forms, following some of his work on the microbiology and ethology of the time. The real difference is not between the living and the nonliving, but between two modes of bonding and composition variously operating on all scales: morphogenetic and statistical. I conclude by assessing the significance of this claim with respect to the traditional distinction between vitalism and mechanism. (shrink)

Disabled‐2 (Dab2) is a multimodular scaffold protein with signaling roles in the domains of cell growth, trafficking, differentiation, and homeostasis. Emerging evidences place Dab2 as a novel modulator of cell–cell interaction; however, its mode of action has remained largely elusive. In this review, we highlight the relevance of Dab2 function in cell signaling and development and provide the most recent and comprehensive analysis of Dab2's action as a mediator of homotypical and heterotypical interactions. Accordingly, Dab‐2 controls the extent of (...) platelet aggregation through various motifs within its N‐terminus. Dab2 interacts with the cytosolic tail of the integrin receptor blocking inside‐out signaling, whereas extracellular Dab2 competes with fibrinogen for integrin αIIbβ3 receptor binding and, thus, modulates outside‐in signaling. An additional level of regulation results from Dab2's association with cell surface lipids, an event that defines the extent of cell–cell interactions. As a multifaceted regulator, Dab2 acts as a mediator of endocytosis through its association with the [FY]xNPx[YF] motifs of internalized cell surface receptors, phosphoinositides, and clathrin. Other emerging roles of Dab2 include its participation in developmental mechanisms required for tissue formation and in modulation of immune responses. This review highlights the various novel mechanisms by which Dab2 mediates an array of signaling events with vast physiological consequences. (shrink)

I offer in this article an account of the distinction between intrinsic and extrinsic properties based on the ontology of modes. Modes are particular properties that directly depend for their identity on their "bearers". In Section 1, I shall introduce the ontology of modes. In Section 2, I shall examine the problem of distinguishing between intrinsic and extrinsic properties by considering another, related problem: that of distinguishing between internal and external relations. In Section 3, I shall present my own account (...) and I shall also single out different degrees of intrinsicality and extrinsicality. In Section 4, I shall deal with missing-relatum modes, namely, with modes that lack specific relata, such as Othello's loving someone. I shall introduce three different theories to deal with them. Finally, in Section 5, I shall solve some problems affecting the intrinsic/extrinsic distinction from the standpoint of my account. (shrink)

Within some ontological theories, bare or thin particulars are the “kernel” of ordinary substances and they are supposed to clarify some key features of the latter, including their nature. In this article, I wish to offer a new theory of bare particulars, based on an interpretation of properties as modes and on a new reading of the dependence relations holding among entities in terms of respects of dependence. In Section 1, I shall introduce bare particulars, modes and respects of dependence. (...) In Section 2, I shall consider the relationships between bare particulars, clothed particulars (i.e., ordinary substances) and their properties. I shall present two models and I shall examine some of their problems. In Section 3 and in Section 4, I shall present a new model by invoking modes and respects of dependence. This will ground my theory of the relationships between bare particulars, clothed particulars and their properties. Finally, in Section 5, I shall compare my model with the second model presented in Section 2 and, in Section 6, I shall deal with some objections against bare particulars and against my own theory. (shrink)

Many scientific disciplines rely on the construction and use of models: biomedical sciences are no exception. This PhD thesis addresses several aspects of the practice of scientific modeling. First, I discuss the nature of modeling as such, proposing a novel, complementary account of scientific modeling which I term the experimentation-driven modeling account and which drives the construction of mechanistic models in many fields of biological and biomedical research, such as cancer immunology. Second, I scrutinize an objection to the mechanistic account (...) of explanation according to which the account fails to accommodate the common practice of idealizing difference-making factors. I argue that this objection ultimately fails because it is riddled with a number of conceptual inconsistencies. Third, I analyze the roles of similarity judgments in some fields of cancer research which employ a variety of mouse models to learn about the disease mechanisms, arguing that by appreciating the epistemic complexities it is possible to shed new light on more general philosophical debates regarding scientific representation. Fourth, mechanisms can also be studied using more theoretical apparatus in the form of simulations. I investigate an example of an agent-based model used to model the outbreak of SARS-CoV-2... (shrink)

Purpose: In the educational field a lack of focus on the process of arriving at a level of profound understanding of a phenomenon can be observed. While classical approaches in education focus on "downloading," repeating, or sometimes optimizing relatively stable chunks of knowledge (both facts and procedural knowledge), this paper proposes to shift the center of attention towards a more dynamic and constructivist perspective: learning as a process of individual and collective knowledge creation and knowledge construction. The goal of this (...) process is to profoundly understand a phenomenon in its multi-dimensionality and complexity and to reflect on the processes that have lead to this understanding. The issue we want to tackle in this paper is how this profound understanding can be brought about in a technology-enhanced learning environment. Method: Part 1 of this paper explores strategies of technology-enhanced knowledge sharing/creation in the field of higher education. Part 2 presents a successful blended learning scenario that illustrates the implementation of these learning strategies in a concrete course design. In this case study students are involved in active theory construction processes by conducting virtual experiments with a virtual organism. Part 3 elaborates on the epistemological implications of this case study. Findings: A constructivist framework for modes of knowing and modes of coming to know is developed. It is shown that -- in order to reach a profound understanding of a phenomenon -- it is essential to take into account the multi-facetted character of knowledge and to use the strategy of double-loop learning. Conclusion: This leads to an understanding of learning/teaching as a process of socio-epistemological engineering. Furthermore, the role of the teacher changes in such a constructivist setting of learning/teaching: Their primary task is to provide a "pedagogically (and technologically) augmented environment." They are responsible for creating an atmosphere of collective knowledge construction and reflection. Beyond the role of a coach and moderator the teacher has to act as a facilitator or "enabler" for the (individual and collective) processes of double-loop learning. (shrink)

Some of Spinoza's most well‐known doctrines concern what kinds of beings there are and how they are related to each other. For example, he claims that: (1) there is only one substance; (2) this substance has infinitely many attributes; (3) this substance is God or nature; (4) each of these attributes express the divine essence; and (5) all else is a mode of the one substance. These claims have so astonished many of his readers that some of them have (...) surely concluded that they must not know what Spinoza means by “substance,”“attribute,” and “mode.” In this article I shall try to explain how Spinoza understands the basic ontological categories denoted by these expressions. (shrink)

In this article, we develop a new approach to integrating philosophical phenomenology with qualitative research. The approach uses phenomenology’s concepts, namely existentials, rather than methods such as the epoché or reductions. We here introduce the approach to both philosophers and qualitative researchers, as we believe that these studies are best conducted through interdisciplinary collaboration. In section 1, we review the debate over phenomenology’s role in qualitative research and argue that qualitative theorists have not taken full advantage of what philosophical phenomenology (...) has to offer, thus motivating the need for new approaches. In section 2, we introduce our alternative approach, which we call Phenomenologically Grounded Qualitative Research (PGQR). Drawing parallels with phenomenology’s applications in the cognitive sciences, we explain how phenomenological grounding can be used to conceptually front-load a qualitative study, establishing an explicit focus on one or more structures of human existence, or of our being in the world. In section 3, we illustrate this approach with an example of a qualitative study carried out by one of the authors: a study of the existential impact of early parental bereavement. In section 4, we clarify the kind of knowledge that phenomenologically grounded studies generate and how it may be integrated with existing approaches. (shrink)

I shall refine in this article Jaegwon Kim's theory of events by appealing to modes, i.e., particular properties that also depend on their 'bearers' for their identity. Events will turn out to be occurrent modes, i.e., relational modes having further modes and times as their relata. In Section 1 I shall briefly present Kim's theory and some difficulties that affect it. In Section 2, after having made some preliminary assumptions on modes and universals, I shall introduce occurrent modes. In Section (...) 3 I shall show how my theory can deal with the difficulties discussed in Section 1. (shrink)

The use of Web 2.0 technologies in the classroom is becoming more widespread, as educators begin to recognise their use as effective learning and teaching tools. Web 2.0 facilitates new modes of social interaction that offer the potential to enrich university educational activities. New roles, structures and activities can be enabled, engendering new forms of creativity and increasing the availability of and extent of access to information. Yet in achieving this, such platforms shift the traditional boundaries between educators and their (...) students, between personal and professional lives, raising issues of integrity and pedagogy in unexpected ways. This paper reflects on three personal narratives to examine some of these challenges; the authors conclude by highlighting concerns that universities need to address. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:32. HUME ON MODES As thorough a critic as Norman Kemp Smith states in his investigation of the Treatise that "Hume's treatment of... the complex ideas of modes... need not detain us." Whatever is interesting in this brief treatment, Smith suggests, rests on remarkable features of Humean doctrine, elsewhere expounded at length. This is true, I would agree, as a descriptive comment to the following degree. The category of (...) modes is officially regarded by Hume as highly marginal, even dispensible. But it is not in fact the case that, intrasystematically, the work of modes can be duplicated in non-modal materials. In this discussion I will show that Hume mistakes the case, and attempts to diagnose the error's deep sources. To the naked eye, the mistake seems perhaps small and reparable. Placed under the microscope, we find an important philosophical conception is at stake. Our raw material comprises the explanations of modality provided by Locke and Hume. Modes, according to Locke, are complex ideas which, however compounded, contain not in them the supposition of subsisting by themselves, but are considered as dependences on, or affections of, substances; such are the ideas signified by the words, triangle, grati2 tude, murder, etc. (2.12.4). Hume's account is similar in appearance. The idea... of a mode... is nothing but a collection of simple ideas.... The simple ideas of which modes are formed, either represent qualities, which are not united by contiguity and causation, but are dispers ' d in different subjects ; or if 33. they be all united together, the uniting principle is not regarded as the foundation of the complex idea. The idea of a dance is an instance of the first kind of modes; that of beauty of the second (I. I. VI). The appearance of harmony is capped by the uniformity in examples: Locke also mentions 'beauty' (2.12.5) as a modal term, and between his 'murder' and Hume's 'dance' there is nothing to choose. One small difference remains. The idea of dependence, prominent in Locke's sketch, is absent from the Treatise passage quoted. This disparity is eliminated by the following remark, temporarily withheld above: the difference betwixt [substances and modes] consists in this, that the particular qualities, which form a substance, are commonly referr'd to an unknown something, in which they are supposed to inhere (I. I. VI). Superficially then, both Locke and Hume might be thought to subscribe to the following theses. The designata of modal terms, but not of substantial terms, lack independence (I will call this 'the Modal Dependence Thesis' or 'MDT'). Modal terms designate complex ideas in the same way as do those substantial terms which designate complex ideas (this will be referred to as 'the Modal Complexity Thesis' or 1MCT'). But while Locke supports MDT, Hume rejects it, and whereas Hume advocates MCT, Locke — when pressed — will be found to disagree with it. Let us start with MDT. To establish that the category of modes is regarded, intrasystematically, as superfluous by Hume is to confirm the disagreement here between the two theorists. Hume categorically dismisses what Locke describes by the phrase 'a something I know not what' as contributing 34. to any particular idea of a substance. Accordingly, the designata of modal as well as substantial terms resolve identically under analysis, i.e. into combinations of simple ideas. Hume mentions a differentiating factor: the principle of union of simple ideas in the case of a substance scores higher in naturalness than in the case of a mode. The components of a substantial idea are "closely and inseparably connected by the relations of contiguity and causation" (I. I. VI), which are 'natural'. But Hume's own examples expose this as an ineffective device of differentiation, one to which Hume himself attaches little importance. Where is the unnaturalness in the case of the (modal) designata of 'beauty' and 'dance'? How — more pointedly — is the complexity involved in the (substantial) designata of 'dog' and 'table' more natural? Any difference here is one that Hume does well to play down and neutralise of all but sentimental significance. In adducing the idea of naturalness to explain the difference felt by the common... (shrink)

Nietzsche's GM 1 is now a recognized masterpiece, but there are still widely varying views about its historical aims and methods.2 What is clear is that Nietzsche's decision to call this work a "genealogy" signals that its purpose is to trace morality's ancestors in the history of human valuing.3 It is also generally agreed that this genealogy is intended to serve a critical function, as Nietzsche himself says, "we need a critique of moral values, for once the value of these (...) values must itself be called into question—and for this we need a knowledge of the conditions and circumstances out of which they have grown [...] developed and shifted [...]". Indeed, Nietzsche's GM is regarded as strikingly... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:russell: the Journal of Bertrand Russell Studies n.s. 33 (winter 2013–14): 173–90 The Bertrand Russell Research Centre, McMaster U. issn 0036–01631; online 1913–8032 c:\users\kenneth\documents\type3302\rj 33,2 114 red.docx 2014-01-31 8:29 PM oeviews MODES AND LEVELS OF PERPLEXITY I. Grattan-Guinness Middlesex U. Business School Hendon, London nw4 4bt, uk [email protected] John Ongley and Rosalind Carey. Russell: a Guide for the Perplexed. London: Bloomsbury, 2013. Pp. ix, 212. isbn: 978-0-8264-9753-6. £45 (hb), (...) £14.99 (pb); us$80 (hb), us$24.95 (pb). i his book is the 41st in a series of guides to the work of various philosophers and philosopher groups, written at a level of readability for students. The authors survey the course of Bertrand Russell’s philosophical career, starting out with his work on logic and mathematics. The main philosophical tools are presented: in logic, they are term, proposition, proposition function, relation, paradox, and first- vis-à-vis higher-order logic. Then, moving on to epistemology, the principal philosophical notions are presented, such as sense-data, facts related to language, Russell’s overriding preference for positivistic philosophies and suspicions of metaphysics, knowledge by acquaintance and by description, theories of truth, logical atomism, percept, events, meaning, and inference in the context of scientific theories. It is nice to have many of the principal components of Russell’s philosophy exhibited together, including the later works An Inquiry into Meaning and Truth and Human Knowledge. The perplexed reader would like to be given precise references for Russell’s assertions on various points, especially when he was so prolific. A cited short item does not need more precision; but the two main chapters that cover the logic and epistemology story often seem to invoke The Principles of Mathematics or Principia Mathematica and yet contain only one precise citation of a longer text in their 64 pages (p. 85). The other chapters of the book are somewhat better in this respect. The index is excellent, though W. V. Quine was missed at pp. 29–30. The table of contents would have benefited from including the titles of the sections. q= 174 Reviews c:\users\kenneth\documents\type3302\rj 33,2 113 red.docx 2014-01-15 10:04 ii Much ground is covered; however, the account is mitigated by the failure to provide a biographical factual survey that should have constituted the opening chapter. Little or no description or explanation is given of, among others, Cambridge University, its mathematical tripos, Russell’s research fellowship in 1895, the philosophical journals Mind and The Monist, Russell’s conversion from neo-Hegelian to positivistic philosophy following G. E. Moore around 1899, the start of personal contacts with Giuseppe Peano in 1900, the gradual involvement of A. N. Whitehead from around 1902, the financial rescue of Principia Mathematica by the grant from the Royal Society in 1909, the serious mistake in Volume 2 detected by Whitehead in 1911 while it was in press, the initial contact with Ludwig Wittgenstein from 1911, Russell’s switch from logic to epistemology in the early 1910s, Whitehead’s intentions for the fourth volume of Principia that was abandoned in 1918, the circumstances of the second edition published in the mid-1920s, Russell’s partial return to serious philosophical writings from the mid-1930s onwards, or the Trinity fellowship from 1944. Presumably the authors have made most of these omissions intentionally ; but the target audience is the loser. The opening “introduction” does mention some of these events and publications ; but its purpose is to provide a preliminary look at some of the main features of Russell’s logic, including the comprehension axiom “that every predicate defines a class” (p. 3), type theory, definite descriptions, “the noclass theory of classes” (p. 10), and the status and role of “analysis”. Why do these features need prologues when the others do not? When they are re-discussed in the later chapters on logic and epistemology, several near-repetitions occur. Furthermore, quantification does not receive sufficient consideration in the book; and the logical connectives and rules of inference none at... (shrink)

Objectives: Recent fMRI studies have shown that it is possible to reliably identify the defaultmode network (DMN) in the absence of any task, by resting-state connectivity analyses in healthy volunteers. We here aimed to identify the DMN in the challenging patient population of disorders of consciousness encountered following coma. Experimental design: A spatial independent component analysis-based methodology permitted DMN assessment, decomposing connectivity in all its different sources either neuronal or artifactual. Three different selection criteria were introduced assessing anticorrelation-corrected connectivity with (...) or without an automatic masking procedure and calculating connectivity scores encompassing both spatial and temporal properties. These three methods were validated on 10 healthy controls and applied to an independent group of 8 healthy controls and 11 severely brain-damaged patients [locked-in syndrome (n ¼ 2), minimally conscious (n ¼ 1), and vegetative state (n ¼ 8)]. Principal observations: All vegetative patients showed fewer connections in the default-mode areas, when compared with controls, contrary to locked-in patients who showed nearnormal connectivity. In the minimally conscious-state patient, only the two selection criteria considering both spatial and temporal properties were able to identify an intact right lateralized BOLD connectivity pattern, and metabolic PET data suggested its neuronal origin. Conclusions: When assess-. (shrink)

Although the Bcl‐2 family members and p53 are involved in the regulation of apoptosis, the status of apoptotic machinery (eg caspases) plays a major role in determining the mode and timing of cell death. If the apoptotic machinery is lost, inhibited, or intrinsically inactivated, the “death stars”, Bcl‐2 and p53, may become irrelevant to cell death. In this light, high levels of Bcl‐2 may indicate that downstream apoptotic pathways are still functional. This explains why Bcl‐2 overexpression can be a (...) marker of chemosensitivity and favorable prognosis in certain cancers and why retention of wild‐type p53 may manifest inactivation of caspases in aggressive cancers. BioEssays 23:947–953, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Healthcare applications of AI have the potential to produce great benefit, but also come with significant ethical risks. This has brought ethics to the forefront of academic, policy and public debates about AI in healthcare. To help navigate these debates, we distinguish three general modes of ethical theorizing in contemporary secular AI ethics: (1) idealism, which seeks to articulate moral ideals that can be applied to concrete problems; (2) realism, which focuses on understanding complex social realities that underpin ethical problems; (...) and (3) pragmatism, which promotes deliberate methods that allow joint action in the present but also enable to future moral growth and progress. We discuss the strengths and weaknesses of each of these modes and illustrate their relevance to salient ethical problems arising from AI in healthcare. Finally, we argue that, while all three have merits, pragmatist approaches deserve more attention they have received thus far. (shrink)

Beginning with a case vignette, this paper uses a semiotic approach to analyze several different kinds of understanding used in clinical medicine. By outlining semiotic structures, four distinct modes of understanding can be defined: (1) the representational mode, corresponding to scientific medicine; (2) the pragmatic mode, constituting the basic standpoint of medicine; (3) the hermeneutic mode, underlying the empathic, humanistic spirit of medicine; and (4) the ontologic mode, associated with both the ethical and ritual aspects of (...) medicine. Clarifying the relationship between these modes avoids common confusions in clinical situations. Although experienced clinicians intuitively use these different modes, they do not necessarily reflect upon them. They are instead mindful of them, and this unique multi-modal consciousness, I suggest, provides a model for integrating theory and practice. (shrink)

Spinoza's Mediate Infinite Mode TAD M. SCHMALTZ IN PART I of the Ethics, Spinoza argued that a modification is infinite just in case it either "follows from the absolute nature of any attribute of God" or "follows from some attribute of God, as it is modified by such a modification" that is infinite. 1 The main purpose of this argument is to bolster the claim later in this text that a finite modification can follow from a divine attribute only (...) insofar as that attribute is modified by another finite modification. 2 Thus it is understandable that in the section that contains the argument Spinoza did not actually affirm the existence of the two kinds of infinite modifications he mentioned, which following standard practice I call "immediate infinite modes" and "mediate infinite modes," respectively.3 Yet in this section he did 'E IP21,D-22,D, G II 65-66/Curley 429-3 o. In the text and notes of this paper I use the following abbreviations pertaining to Spinoza's writings: E: Ethics ; Ep.: Letters ; RDPP: Descartes' Principles of Philosophy ; CM: Appendix containing Metaphysical Thoughts ; KV: Short Treatise ; TdlE: Treatise on the Emendation of the Intellect ; G: C. Gebhardt, ed., Spinoza Opera, 4 vols. , cited by volume and page; Curley: E. Curley, trans, and ed., The Collected Works of.. (shrink)

Is there really such a thing as a masculine style of writing? What are its characteristics and why just these characteristics? Can we distinguish the masculine style from the explicit masculine content? The writers I will examine in this context are necessarily a selection from the number of those who might be included. They are all twentieth-century authors. Perhaps, as Woolf suggests in A Room of One's Own, it is because of the beginnings of the women's movement in the preceding (...) century that "virility has now become self-conscious."1 At any rate there seems to be little explicit questioning of the male role, in literature or outside it, until our own century. I do not mean to suggest, however, that these writers only question the received images of maleness; often they set out to validate those images or, through such images, to validate themselves. Their explorations of maleness are not abstract but intensely individual. They are not straightforward but riddled with contradictions and paradoxes. As a result, it is difficult to extract didactic points from their works. Always knowledge is rooted in experience and inseparable from it. The masculine mode is above all an attempt to render a certain maleness of experience. · 1. Virginia Woolf, A Room of One's Own , p. 105. Peter Schwenger, assistant professor of English at Mount St. Vincent University in Halifax, has written Phallic Critiques, which examines the relation between masculinity and literary styles. See also: "Virginia Woolf's Criticism: A Polemical Preface" by Barbara Currier Bell and Carol Ohmann in Vol. 1, No. 2. (shrink)

This paper introduces a novel method to control the operation of the active suspension system. In this research, a quarter-dynamic model is used to simulate the vehicle’s vibrations. Besides, the sliding mode-PID-integrated algorithm with five state variables is proposed to be used. This is a completely original and novel algorithm. The process of establishing the control algorithm is clearly described. The simulation is performed by the MATLAB software. The results of the paper have shown the advantages of the sliding (...) mode-PID algorithm used in this research. Accordingly, the displacement and acceleration of the sprung mass were significantly reduced when this algorithm was used. The maximum and average values of the displacement of the sprung mass are only 1.31% and 1.29%, respectively, compared with the situation of the vehicle using a passive suspension. Similarly, the value of the acceleration is 6.98% and 2.94%, respectively. In addition, the phenomenon of “chattering” has also been significantly reduced when using this controller. In the future, some more complex algorithms can be proposed. (shrink)

We show that for every we ordered cardinal number m the Tychonoff product 2m is a compact space without the use of any choice but in Cohen's Second Mode 2ℝ is not compact.

Carmen4.2 is one of the most commented upon of the odes of Horace. It is indeed a complex poem. To summarize roughly: addressing the young poet Iullus Antonius, Horace presents the dangers of emulating Pindar, offering what seems like a lengthy description as well as an approximation of Pindar's own poetic style (1–24). Not as a doomed Icarus imitating the grand Pindaric swan, but in his own preferred mode, like a bee on the banks of Tibur, Horace will continue (...) to produce his own highly refined poems on a small scale (25–30). Iullus Antonius, on the other hand, will sing of Augustus’ triumphmaiore plectro(33, a phrase which in all likelihood refers to his activity as an epic poet). Modestly, Horace himself will be content to join in with the popular chants for Augustus’ triumphal return as one happy civilian among the crowd (33–52). Iullus Antonius will moreover offer a grand sacrifice of ten bulls and as many cows on that occasion, whereas Horace promises a single bull-calf that he is saving especially for the purpose (53–60). I will try to offer a new interpretation of these last two strophes by pointing out an unnoticed allusion to a Hellenistic subtext. (shrink)

The understanding of food cue associated neural activations that predict future weight variability may guide the design of effective prevention programs and treatments for overeating and obesity. The current study investigated the association between brain response to different food odors with varied energy density and individual changes of body mass index (BMI) over two years. Twenty-five participants received high-fat (chocolate and peanut), low-fat (bread and peach) food odors and a nonfood odor (rose) while the brain activation was measured using functional (...) magnetic resonance imaging (fMRI). BMIs were calculated with participant’s self-reported body weight and height collected at the time of fMRI scan and again at two years later. Regression analyses revealed significant negative correlations between BMI increase over 2 years and brain activation of the bilateral precuneus and the right posterior cingulate cortex in response to high-fat versus low-fat food odors. In addition, brain activation of the right supplementary motor area in response to food vs non-food odor was negatively correlated to subsequent BMI increase over 2 years. Taken together, the current findings suggest that individual differences in neural responsivity to (high calorie) food odors in brain regions of the default mode and motor control network serve as a neural marker for future BMI change. (shrink)

Regulation of the subcellular localization of certain proteins is a mechanism for the regulation of their biological activities. FGF‐2 can be produced as distinct isoforms by alternative initiation of translation on a single mRNA and the isoforms are differently sorted in cells. High molecular weight FGF‐2 isoforms are not secreted from the cell, but are transported to the nucleus where they regulate cell growth or behavior in an intracrine fashion. 18 kDa FGF‐2 can be secreted to the extracellular medium where (...) it acts as a conventional growth factor by binding to and activation of cell‐surface receptors. Furthermore, following receptor‐mediated endocytosis, the exogenous FGF‐2 can be transported to the nuclei of target cells, and this is of importance for the transmittance of a mitogenic signal. The growth factor is able to interact with several intracellular proteins. Here, the mode of action and biological role of intracellular FGF‐2 are discussed. BioEssays 28: 504–514, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

The complex spectral representation of the Liouville operator introduced by Prigogine and others is applied to moderately dense gases interacting through hard-core potentials in arbitrary d-dimensional spaces. Kinetic equations near equilibrium are constructed in each subspace as introduced in the spectral decomposition for collective, renormalized reduced distribution functions. Our renormalization is a nonequilibrium effect, as the renormalization effect disappears at equilibrium. It is remarkable that our renormalized functions strictly obey well-defined Markovian kinetic equations for all d, even though the ordinary (...) distribution functions obey nonMarkovian equations with memory effects. One can now define transport coefficients associated to the collective modes for all dimensional systems including d = 2. Our formulation hence provides a microscopic meaning of the macroscopic transport theory. Moreover, this gives an answer to the long-standing question whether or not transport equations exist in two-dimensional systems. The non-Markovian effects for the ordinary distribution function, such as the long-time tails for arbitrary n-mode coupling, are estimated by superposition of the Markovian evolutions of the dressed distribution functions. (shrink)

Volume 3, Issue 2, June 2019, Page 123-130.

With the development of modern information technology, the flipped classroom teaching mode came into being. It has gradually become one of the hotspots of contemporary educational circles and has been applied to various disciplines at the same time. The domestic research on the flipped classroom teaching mode is still in the exploratory stage. The application of flipped classroom teaching mode is still in the exploratory stage. It also has many problems, such as low class efficiency, poor teacher-student (...) interaction, outdated teaching modes, not student-centered, etc., which lead to poor students’ enthusiasm for learning. Therefore, the current English flipped classroom teaching mode still needs to be tested and revised in practice. Combined with emotion recognition technology, this paper analyzes speech emotion recognition, image emotion recognition, and audition emotion recognition technology and conducts a revision test for the current English flipped classroom teaching mode. It uses the SVM algorithm for one-to-one method and dimension discretization for emotion recognition, and finds that the recognition results after different dimension classification recognition are improved for each emotion. Among them, the recognition rate of different dimension classification recognition methods is 2.6% higher than that of one-to-one method. This shows that under the same conditions, the emotion recognition technology of different dimension classification recognition methods is higher. (shrink)