Results for 'mutation bias'

987 found
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  1.  48
    Genome analyses substantiate male mutation bias in many species.Melissa A. Wilson Sayres & Kateryna D. Makova - 2011 - Bioessays 33 (12):938-945.
    In many species the mutation rate is higher in males than in females, a phenomenon denoted as male mutation bias. This is often observed in animals where males produce many more sperm than females produce eggs, and is thought to result from differences in the number of replication‐associated mutations accumulated in each sex. Thus, studies of male mutation bias have the capacity to reveal information about the replication‐dependent or replication‐independent nature of different mutations. The availability (...)
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  2.  16
    A Trait-based framework for mutation bias as a driver of long-term evolutionary trends.Julian Z. Xue, André Costopoulos & Frédéric Guichard - 2016 - Complexity 21 (5):331-345.
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  3.  17
    Meiotic recombination: A mechanism for tracking and eliminating mutations?Bruce D. McKee - 1996 - Bioessays 18 (5):411-419.
    The function of meiotic recombination has remained controversial, despite recent inroads into mechanisms. Ideas concerning a possible role of recombination in the elimination or efficient incorporation of mutations have been backed by theoretical studies but have lacked empirical support. Recent investigations into the basis for local variations in recombination frequency in yeast have uncovered a strong association between recombination initiation sites and transcriptional regulatory sequences. Other recent studies indicate a strong correlation between transcription and mutation rates in yeast genes. (...)
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  4.  18
    Negative CG dinucleotide bias: An explanation based on feedback loops between Arginine codon assignments and theoretical minimal RNA rings.Jacques Demongeot, Andrés Moreira & Hervé Seligmann - 2021 - Bioessays 43 (3):2000071.
    Theoretical minimal RNA rings are candidate primordial genes evolved for non‐redundant coding of the genetic code's 22 coding signals (one codon per biogenic amino acid, a start and a stop codon) over the shortest possible length: 29520 22‐nucleotide‐long RNA rings solve this min‐max constraint. Numerous RNA ring properties are reminiscent of natural genes. Here we present analyses showing that all RNA rings lack dinucleotide CG (a mutable, chemically instable dinucleotide coding for Arginine), bearing a resemblance to known CG‐depleted genomes. CG (...)
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  5. What You Can Do for Evolutionary Developmental Linguistics.William C. Bausman & Marcel Weber - 2024 - European Journal for Philosophy of Science 15 (1):1-18.
    A growing number of linguistic attempts to explain how languages change use cultural-evolutionary models involving selection or drift. Developmental constraints and biases, which take center stage in evolutionary developmental biology or evo-devo, seem to be absent within this framework, even though linguistics is home to numerous notions of constraint. In this paper, we show how these evo-devo concepts could be applied to linguistic change and why they should. This requires some conceptual groundwork, due to important differences between linguistic and biotic (...)
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  6.  30
    Phylogeny of γ‐proteobacteria: resolution of one branch of the universal tree?James R. Brown & Craig Volker - 2004 - Bioessays 26 (5):463-468.
    The reconstruction of bacterial evolutionary relationships has proven to be a daunting task because variable mutation rates and horizontal gene transfer (HGT) among species can cause grave incongruities between phylogenetic trees based on single genes. Recently, a highly robust phylogenetic tree was constructed for 13 γ‐proteobacteria using the combined alignments of 205 conserved orthologous proteins.1 Only two proteins had incongruent tree topologies, which were attributed to HGT between Pseudomonas species and Vibrio cholerae or enterics. While the evolutionary relationships among (...)
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  7.  36
    Examining the “Best of Both Worlds” of Grammatical Evolution.Peter Whigham, Grant Dick, James Maclaurin & Caitlin Owen - 2015 - Proceedings of the 2015 Genetic and Evolutionary Computation 2015:1111-1118.
    Grammatical Evolution (GE) has a long history in evolutionary computation. Central to the behaviour of GE is the use of a linear representation and grammar to map individuals from search spaces into problem spaces. This genotype to phenotype mapping is often argued as a distinguishing property of GE relative to other techniques, such as context-free grammar genetic programming (CFG-GP). Since its initial description, GE research has attempted to incorporate information from the grammar into crossover, mutation, and individual initialisation, blurring (...)
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  8.  53
    Umbrella and basket trials in oncology: ethical challenges.Karolina Strzebonska & Marcin Waligora - 2019 - BMC Medical Ethics 20 (1):1-10.
    Novel precision oncology trial designs, such as basket and umbrella trials, are designed to test new anticancer agents in more effective and affordable ways. However, they present some ethical concerns referred to scientific validity, risk-benefit balance and informed consent. Our aim is to discuss these issues in basket and umbrella trials, giving examples of two ongoing cancer trials: NCI-MATCH (National Cancer Institute – Molecular Analysis for Therapy Choice) and Lung-MAP (Lung Cancer Master Protocol) study. We discuss three ethical requirements for (...)
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  9.  53
    (1 other version)Meme and variations: A computational model of cultural evolution.L. Gabora - 1995 - In [Book Chapter].
    This paper describes a computational model of how ideas, or memes, evolve through the processes of variation, selection, and replication. Every iteration, each neural-network based agent in an artificial society has the opportunity to acquire a new meme, either through 1) INNOVATION, by mutating a previously-learned meme, or 2) IMITATION, by copying a meme performed by a neighbor. Imitation, mental simulation, and using past experience to bias mutation all increase the rate at which fitter memes evolve. Memes at (...)
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  10.  45
    Why are most organelle genomes transmitted maternally?Stephan Greiner, Johanna Sobanski & Ralph Bock - 2015 - Bioessays 37 (1):80-94.
    Why the DNA‐containing organelles, chloroplasts, and mitochondria, are inherited maternally is a long standing and unsolved question. However, recent years have seen a paradigm shift, in that the absoluteness of uniparental inheritance is increasingly questioned. Here, we review the field and propose a unifying model for organelle inheritance. We argue that the predominance of the maternal mode is a result of higher mutational load in the paternal gamete. Uniparental inheritance evolved from relaxed organelle inheritance patterns because it avoids the spread (...)
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  11.  9
    Local Search and the Evolution of World Models.Neil R. Bramley, Bonan Zhao, Tadeg Quillien & Christopher G. Lucas - forthcoming - Topics in Cognitive Science.
    An open question regarding how people develop their models of the world is how new candidates are generated for consideration out of infinitely many possibilities. We discuss the role that evolutionary mechanisms play in this process. Specifically, we argue that when it comes to developing a global world model, innovation is necessarily incremental, involving the generation and selection among random local mutations and recombinations of (parts of) one's current model. We argue that, by narrowing and guiding exploration, this feature of (...)
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  12.  11
    From Stars to Brains: Milestones in the Planetary Evolution of Life and Intelligence.Andrew Y. Glikson - 2019 - Cham: Springer Verlag.
    The permutation of basic atoms—nitrogen, hydrogen, oxygen, carbon and phosphorus―into the biomolecules DNA and RNA, subsequently evolved in cells and brains, defining the origin of life and intelligence, remains unexplained. Equally the origin of the genetic information and the intertwined nature of ‘hardware’ and ‘software’ involved in the evolution of bio-molecules and the cells are shrouded in mystery. This treatise aims at exploring individual and swarm behaviour patterns which potentially hint at as yet unknown biological principles. It reviews theories of (...)
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  13. The gender of illiberalism : new transnational alliances against open societies in Central and Eastern Europe.Katalin Fábián - 2023 - In Christof Royer & Liviu Matei (eds.), Open society unresolved: the contemporary relevance of a contested idea. New York: Central European University Press.
  14. Semantica e lessicologia storiche: atti del XXXII Congresso internazionale di studi, Budapest 29-31 ottobre 1998.Zsuzsanna Fábián & Giampaolo Salvi (eds.) - 2001 - Roma: Bulzoni.
     
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  15.  10
    Művészet és tér: Hamvas Béla-konferencia balatonfüred, 2014. március 21-22.Krisztián Tóbiás, László Cserép & István Nádler (eds.) - 2014 - Balatonfüred: Balatonfüred Városért Közalapítvány.
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  16. Apáczai Csere János: Kismonográfia.Ernő Fábián - 1975 - Kolozsvár-Napoca: Dacia.
     
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  17.  54
    A note on deduction theorem for Gödel's propositional calculus G4.Ewa Żarnecka-Biaŀy - 1968 - Studia Logica 23 (1):35-40.
  18. Australasian Journal of Philosophy Contents of Volume 91.Present Desire Satisfaction, Past Well-Being, Volatile Reasons, Epistemic Focal Bias, Some Evidence is False, Counting Stages, Vague Entailment, What Russell Couldn'T. Describe, Liberal Thinking & Intentional Action First - 2013 - Australasian Journal of Philosophy 91 (4).
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  19. On Preferring that Overall, Things are Worse: Future‐Bias and Unequal Payoffs.Preston Greene, Andrew J. Latham, Kristie Miller & James Norton - 2021 - Philosophy and Phenomenological Research 105 (1):181-194.
    Philosophers working on time-biases assume that people are hedonically biased toward the future. A hedonically future-biased agent prefers pleasurable experiences to be future instead of past, and painful experiences to be past instead of future. Philosophers further predict that this bias is strong enough to apply to unequal payoffs: people often prefer less pleasurable future experiences to more pleasurable past ones, and more painful past experiences to less painful future ones. In addition, philosophers have predicted that future-bias is (...)
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  20. Attitude, Inference, Association: On the Propositional Structure of Implicit Bias.Eric Mandelbaum - 2015 - Noûs 50 (3):629-658.
    The overwhelming majority of those who theorize about implicit biases posit that these biases are caused by some sort of association. However, what exactly this claim amounts to is rarely specified. In this paper, I distinguish between different understandings of association, and I argue that the crucial senses of association for elucidating implicit bias are the cognitive structure and mental process senses. A hypothesis is subsequently derived: if associations really underpin implicit biases, then implicit biases should be modulated by (...)
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  21. Robust passage phenomenology probably does not explain future-bias.Andrew J. Latham, Kristie Miller, Christian Tarsney & Hannah Tierney - 2022 - Synthese 200 (1):1-23.
    People are ‘biased toward the future’: all else being equal, we typically prefer to have positive experiences in the future, and negative experiences in the past. Several explanations have been suggested for this pattern of preferences. Adjudicating among these explanations can, among other things, shed light on the rationality of future-bias: For instance, if our preferences are explained by unjustified beliefs or an illusory phenomenology, we might conclude that they are irrational. This paper investigates one hypothesis, according to which (...)
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  22.  25
    Sanctification, Hardening of the Heart, and Frankfurt's Concept of.On Some Worldly Worries, Care Justice & Gender Bias - 1988 - Journal of Philosophy 85 (8):436-437.
  23. Virtue, Social Knowledge, and Implicit Bias.Alex Madva - 2016 - In Michael Brownstein & Jennifer Mather Saul (eds.), Implicit Bias and Philosophy, Volume 1: Metaphysics and Epistemology. Oxford, United Kingdom: Oxford University Press. pp. 191-215.
    This chapter is centered around an apparent tension that research on implicit bias raises between virtue and social knowledge. Research suggests that simply knowing what the prevalent stereotypes are leads individuals to act in prejudiced ways—biasing decisions about whom to trust and whom to ignore, whom to promote and whom to imprison—even if they reflectively reject those stereotypes. Because efforts to combat discrimination obviously depend on knowledge of stereotypes, a question arises about what to do next. This chapter argues (...)
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  24. Identified Person "Bias" as Decreasing Marginal Value of Chances.H. Orri Stefánsson - 2024 - Noûs 58 (2):536-561.
    Many philosophers think that we should use a lottery to decide who gets a good to which two persons have an equal claim but which only one person can get. Some philosophers think that we should save identified persons from harm even at the expense of saving a somewhat greater number of statistical persons from the same harm. I defend a principled way of justifying both judgements, namely, by appealing to the decreasing marginal moral value of survival chances. I identify (...)
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  25.  22
    Sexual Selection Revisited — Towards a Gender-Neutral Theory and Practice: A Response to Vandermassen's `Sexual Selection: A Tale of Male Bias and Feminist Denial'.Malin Ah-King - 2007 - European Journal of Women's Studies 14 (4):341-348.
    In a recent issue of this journal, Vandermassen suggested that feminists should include sexual selection theory and evolutionary psychology in a unifying theory of human nature. In response, this article aims to offer some insight into the development of sexual selection theory, to caution against Vandermassen's unreserved assimilation and to promote the opposite ongoing integration — an inclusion of gender perspectives into evolutionary biology. In society today, opinions about maintaining traditional sex roles are often put forward on the basis of (...)
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  26.  62
    Barristers, the Bar Standards Board and the structural bias of appointing disciplinary tribunals in England and Wales.Zia Akhtar - 2017 - Legal Ethics 20 (1):138-143.
    The rule against bias is a central tenet of English law and it also impacts on collegiate courts which typically exercise appellate/review jurisdictions over their professional or student members. This is true of the Bar Standards Board which has established the adjudicatory bodies to enforce its regulatory framework and has vested the procedure of fair trials upon the Council of the Inns of Court which is responsible for appointing the Disciplinary Tribunal panels that conduct hearings for professional misconduct. The (...)
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  27.  41
    The source of belief bias effects in syllogistic reasoning.Stephen E. Newstead, Paul Pollard, Jonathan StB. T. Evans & Julie L. Allen - 1992 - Cognition 45 (3):257-284.
  28.  30
    In Defence of informed consent for health record research - why arguments from ‘easy rescue’, ‘no harm’ and ‘consent bias’ fail.Thomas Ploug - 2020 - BMC Medical Ethics 21 (1):1-13.
    BackgroundHealth data holds great potential for improved treatments. Big data research and machine learning models have been shown to hold great promise for improved diagnostics and treatment planning. The potential is tied, however, to the availability of personal health data. In recent years, it has been argued that data from health records should be available for health research, and that individuals have a duty to make the data available for such research. A central point of debate is whether such secondary (...)
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  29. Disability, fairness, and algorithmic bias in AI recruitment.Nicholas Tilmes - 2022 - Ethics and Information Technology 24 (2).
    While rapid advances in artificial intelligence hiring tools promise to transform the workplace, these algorithms risk exacerbating existing biases against marginalized groups. In light of these ethical issues, AI vendors have sought to translate normative concepts such as fairness into measurable, mathematical criteria that can be optimized for. However, questions of disability and access often are omitted from these ongoing discussions about algorithmic bias. In this paper, I argue that the multiplicity of different kinds and intensities of people’s disabilities (...)
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  30. Detecting racial bias in algorithms and machine learning.Nicol Turner Lee - 2018 - Journal of Information, Communication and Ethics in Society 16 (3):252-260.
    Purpose The online economy has not resolved the issue of racial bias in its applications. While algorithms are procedures that facilitate automated decision-making, or a sequence of unambiguous instructions, bias is a byproduct of these computations, bringing harm to historically disadvantaged populations. This paper argues that algorithmic biases explicitly and implicitly harm racial groups and lead to forms of discrimination. Relying upon sociological and technical research, the paper offers commentary on the need for more workplace diversity within high-tech (...)
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  31.  52
    What’s wrong with the presentist bias? On the threat of intergenerational domination.Anja Karnein - 2023 - Critical Review of International Social and Political Philosophy 26 (5):725-746.
    What is the wrong behind the widely criticized presentist bias of democracies? In this paper I argue that it is not that future generations are excluded from present-day democratic decision-making quite generally. Rather, I claim that due to the unique risks associated with representing future generations and the limitations on affecting future generations both institutionally and causally, the focus ought to be on including them on a more specific, narrower, set of issues, namely only those that threaten to lead (...)
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  32.  68
    Social Justice, Fallacies of Argument, and Persistent Bias.Catherine Hundleby - 2023 - Argumentation 37 (2):281-293.
    The fallacies approach to argument evaluation can exacerbate problems it aims to address when it comes to social bias, perpetuating social injustice. A diagnosis that an argument commits a fallacy may flag the irrelevance of stereotypical characterizations to the line of reasoning without directly challenging the stereotypes. This becomes most apparent when personal bias is part of the subject matter under discussion, in ethotic argument, including ad hominem and ad verecundiam, which may be recognized as fallacious without addressing (...)
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  33.  25
    Does verb bias modulate syntactic priming?Sarah Bernolet & Robert J. Hartsuiker - 2010 - Cognition 114 (3):455-461.
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  34.  94
    Associations between Hofstede’s Cultural Constructs and Social Desirability Response Bias.Richard A. Bernardi - 2006 - Journal of Business Ethics 65 (1):43-53.
    This paper examines the associations among social desirability response bias, cultural constructs and gender. The study includes the responses of 1537 students from 12 countries including Australia, Canada, China, Colombia, Ecuador, Hong Kong, Ireland, Japan, Nepal, South Africa, Spain, and the United States. The results of the analysis indicate that, on average, social desirability response bias decreases as a country's Individualism increases. The analysis also indicates that women scored significantly higher on Paulhus' Image Management Subscale on an overall (...)
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  35. Reseña del libro "Le passage à l'écriture : mutation culturelle et devenir des savoirs dans une société de l'oralité".Stanislas Deprez - 2010 - Revue Philosophique de la France Et de l'Etranger 135 (4):532-533.
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  36.  6
    The course of evolution by differentiation or divergent mutation rather than by selection.F. R. Simpson - 1941 - The Eugenics Review 33 (1):19.
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  37.  63
    Anxiety and Attentional Bias: State and Trait.Donald Broadbent & Margaret Broadbent - 1988 - Cognition and Emotion 2 (3):165-183.
  38.  32
    Hate Crimes: The legality and Practicality of Punishing Bias—A Socio-Legal Appraisal.Natalie Alkiviadou - 2022 - International Journal for the Semiotics of Law - Revue Internationale de Sémiotique Juridique 35 (5):2013-2025.
    This paper assesses the extent to which enhancing a penalty for hate crimes is a necessity. It conducts its analysis by looking at the theoretical justifications for and against such enhancement and also the impact of hate crimes on their victims, their groups and society, in comparison to non-bias crimes. It recognizes the particularly damaging effect of hate crimes on these three levels but argues that care must be taken to ensure a high threshold framework and a clear vision (...)
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  39.  67
    Relief, time-bias, and the metaphysics of tense.Julian Bacharach - 2022 - Synthese 200 (3):1-22.
    Our emotional lives are full of temporal asymmetries. Salient among these is that we tend to feel differently about painful or unpleasant events depending on their temporal location: we feel anxiety or trepidation about painful events we anticipate in the future, and relief when they are over. One question, then, is whether temporally asymmetric emotions such as relief have any ramifications for the metaphysics of time. On what has become the standard way of finessing this question, the asymmetry of relief (...)
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  40.  29
    What can experimental studies of bias tell us about real-world group disparities?Joseph Cesario - 2022 - Behavioral and Brain Sciences 45:1-80.
    This article questions the widespread use of experimental social psychology to understand real-world group disparities. Standard experimental practice is to design studies in which participants make judgments of targets who vary only on the social categories to which they belong. This is typically done under simplified decision landscapes and with untrained decision-makers. For example, to understand racial disparities in police shootings, researchers show pictures of armed and unarmed Black and White men to undergraduates and have them press “shoot” and “don't (...)
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  41.  71
    If the Facts Were Not Untruths, Their Implications Were: Sponsorship Bias and Misleading Communication.Daniel Steel - 2018 - Kennedy Institute of Ethics Journal 28 (2):119-144.
    The whole drug industry campaign for mood drugs in the 1950s was to broaden to absurd limits the definition of illness.... If the facts in these ads were not untruths, then their implications often were.1Sponsorship bias occurs when a funder of scientific research has a vested interest in what claims the research supports, which consequently shapes the research or the reporting of its results to align with that interest. This article examines the relationship between sponsorship bias and misleading (...)
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  42. Elimination of Bias in Introspection: Methodological Advances, Refinements, and Recommendations.Radek Trnka & Vit Smelik - 2020 - New Ideas in Psychology 56.
    Building on past constructive criticism, the present study provides further methodological development focused on the elimination of bias that may occur during first-person observation. First, various sources of errors that may accompany introspection are distinguished based on previous critical literature. Four main errors are classified, namely attentional, attributional, conceptual, and expressional error. Furthermore, methodological recommendations for the possible elimination of these errors have been determined based on the analysis and focused excerpting of introspective scientific literature. The following groups of (...)
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  43. Self-serving bias and the structure of moral status.Thomas Douglas - 2012 - Journal of Medical Ethics 38 (3):141-142.
    David DeGrazia tentatively defends what he calls the Interests Model of moral status (see page 135).1 On this model all sentient beings have the same moral status, though some are owed more than others in virtue of having more or stronger interests. The proponent of this model can accept, say, that one should normally save the life of a human in preference to that of a dog. But she denies that we should save the human because he has higher moral (...)
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  44.  23
    The Influence of Linguistic Form on Reasoning: The Case of Matching Bias.Jonathan Evans - 1999 - Quarterly Journal of Experimental Psychology Section A 52 (1):185-216.
    A well-established phenomenon in reasoning research is matching bias : a tendency to select information that matches the lexical content of propositional statements, regardless of the logically critical presence of negations. Previous research suggested, however, that the effect might be restricted to reasoning with conditional statements. This paper reports two experiments in which participants were required to construct or identify true and false cases of propositional rules of several kinds, including universal statements, disjunctions, and negated conjunctions. Matching bias (...)
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  45.  35
    Le copernicianisme et la mutation de la philosophie naturelle.Maurice Clavelin - 2004 - Revue de Métaphysique et de Morale 3 (3):353-370.
    Le but de cette étude est de faire apparaître le rôle éminent que joua le copernicianisme dans le remplacement, en un siècle et demi à peine (1543-1687), de la philosophie naturelle traditionnelle par la science moderne. Son idée directrice est qu’en dépit de ses implications théoriquement incompatibles avec la philosophie naturelle traditionnelle, le copernicianisme n’exerça pleinement son pouvoir rénovateur que grâce à un afflux de données inédites, inassimilables par l’ancien système, ou encore d’initiatives théoriques dont le développement n’eût pas été (...)
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  46.  34
    To blame? The effects of moralized feedback on implicit racial bias.Jules Holroyd, Robin Scaife, Tom Stafford & Andreas Bunge - 2020 - Collabra: Psychology 6 (1).
    Implicit bias training (IBT) is now frequently provided by employers, in order to raise awareness of the problems related to implicit biases, and of how to safeguard against discrimination that may result. However, as Atewologun et al (2018) have noted, there is very little systematicity in IBT, and there are many unknowns about what constitutes good IBT. One important issue concerns the tone of information provided regarding implicit bias. This paper engages this question, focusing in particular on the (...)
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  47.  7
    La grande mutation: enquête sur la fin d'un millénaire.François L'Yvonnet (ed.) - 1998 - [Paris]: Editions Albin Michel.
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  48. Attitudes as accessibility bias: Dissociating automatic and controlled processes.B. Keith Payne, Larry L. Jacoby & Alan J. Lambert - 2005 - In Ran R. Hassin, James S. Uleman & John A. Bargh (eds.), The New Unconscious. Oxford Series in Social Cognition and Social Neuroscience. New York: Oxford University Press. pp. 393-420.
  49. Whiteliness and institutional racism: hiding behind (un)conscious bias.Shirley Anne Tate & Damien Page - 2018 - Ethics and Education 13 (1):141-155.
    ‘Unconscious bias happens by our brains making incredibly quick judgements and assessments without us realising. Biases are influenced by background, cultural environment and experiences and we may not be aware of these views and opinions, or of their full impact and implications. This article opposes this point of view by arguing that bias is not unconscious but is conscious and linked to Charles Mills’ ‘Racial Contract’ and its ‘epistemologies of ignorance’. These epistemologies emerge from what the Equality Challenge (...)
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  50.  26
    Sensitivity and response bias in fear of spiders.Eni Becker & Mike Rinck - 2004 - Cognition and Emotion 18 (7):961-976.
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