The concept of moral wrongness, many think, has a distinctive kind of referential stability, brought out by moral twin earth cases. This article offers a new account of the source of this stability, deriving it from a metaphysics of content: “substantive” radical interpretation, and first-order normative assumptions. This story is distinguished from extant “reference magnetic” explanations of the phenomenon, and objections and replies are considered.

such light matter as you fancy, or the work of light or chance persons; and Cratylus is right in thinking that things have names by nature, and that not every man is an artificer of names, but he only who looks to the name which each thing by nature.

David Lewis is associated with the controversial thesis that some properties are more eligible than others to be the referents of our predicates solely in virtue of those properties’ being more natural; independently, that is, of anything to do with our patterns of usage of the relevant predicates. On such a view, the natural properties act as ‘reference magnets’. In this paper I explore (though I do not endorse) a related thesis in epistemology: that some propositions are ‘justification (...) magnets’. According to the doctrine of justification magnetism, we have better justification for some propositions than for others solely in virtue of certain features of those propositions; independently, that is, of anything to do with evidential support or cognitive accomplishment. In the course of discussing an objection to justification magnetism I describe (though I do not endorse) a novel approach to epistemology akin to interpretationism in the theory of reference. (shrink)

Since antiquity, sources report that garlic deprives a magnet of its power of attraction. Although in later centuries some authors disproved or questioned this effect by experience or trial, several, if not the majority of, writers referred to garlic and magnets as “enemies” until well into the seventeenth century. It will be argued that the probable textual origin of the “garlic effect” is a corrupt or ambiguous passage in Pliny’s Natural History, reading “al(l)ium” (garlic) instead of “aliud” (another) in (...) one passage. With a focus on the early-modern period, it will be elucidated why so many authors did not doubt this physical effect, and some even presented causal explanations for it. It shall be emphasized, moreover, that magnetic attraction, and thereby also the garlic effect, was used as an important example or analogy since antiquity. This illustrative or explanatory use of analogies drawn from the garlic–magnet antipathy certainly goes some way towards explaining the longevity of this odd relation between the two substances. (shrink)

Mathematical tradition has it that transformations characterized by a negative Jacobian determinant are referred to as improper transformations. The symmetry of a physical object corresponding to such an improper transformation becomes an improper symmetry. Improper symmetries have been successfully used for the purpose of crystal symmetry. The extension of these purely spatial symmetries to the domain of spacetime has led to a prejudicial use of light-cone properties, thus affecting adversely an unbiased symmetry classification. We pinpoint these prejudicial procedures and trace (...) their historical origin, while presenting an alternative that restores an unbiased treatment of improper spacetime symmetries. The applications discussed relate to recent developments in the symmetry classification of magnetic crystals and to the extension of Neumann's principle to the time domain. (shrink)

*This work has turned into a bigger project, and some of it is published in "Lewis on reference".* Some things, argues Lewis, are just better candidates to be referents than others. Even at the cost of attributing false beliefs, we interpret people as referring to the most interesting kinds in their vicinity. How should this be accounted for? In section 1, I look at Lewis’s interpretationism, and the reference magnetism it builds in (not just for ‘perfectly natural’ properties, (...) but for certain kinds of auxiliary apparatus). In section 2, I draw on (Field, 1975) to argue that what properties are reference magnetic may be an ultimately conventional matter—though in the Lewisian setting, there may be an objectively best conventional choice to make. But Lewis’s own account has implausible commitments, so in section 3 I consider variations and alternatives, all of which have problems. In section 4, I look in more detail at eligibility-based interpretationism that do not appeal to naturalness, arguing that there are credible metasemantic theories of this form. (shrink)

This paper examines whether realists can explain co-reference without appealing to subjects’ ideal convergence in judgment. This question is particularly pressing in the normative domain, since deep disagreement about the applicability of normative predicates suggests that different speakers may not pick out the same property when they use normative terms. Normative realists, we believe, have not been sufficiently aware of the difficulties involved in providing a theory of reference-determination. Our aim in this paper is to clarify the nature (...) of this reference-fixing task and the challenges that arise for a non-convergentist normative realist. Our focal point will be Richard Boyd’s externalist account, which has been a model for non-convergentist theories of reference in metaethics. A close examination of Boyd’s account of reference and the ways it could be developed or supplemented, we’ll argue, suggests that explaining co-reference without convergence in the normative domain is a more challenging problem than many realists have supposed. (shrink)

Objective: The aim of the study was to identify clinical variables associated with changes in specific domains of self-reported depression during treatment by antidepressant and/or repetitive Transcranial Magnetic Stimulation in patients with Major Depressive Disorder.Methods: Data from a trial involving 170 patients with MDD receiving either venlafaxine, rTMS or both were re-analyzed. Depressive symptoms were assessed each week during the 2 to 6 weeks of treatment with the 13-item Beck Depression Inventory. Associations between depression changes on BDI13 domains, treatment arm, (...) time, and clinical variables were tested in a mixed linear model.Results: A significant decrease of self-reported depressive symptoms was observed over time. The main characteristics associated with persistent higher depressive symptomatology on Negative Self-Reference domain of the BDI13 were personality disorders, a past history of suicide attempt, age under 65 years old, and female sex.Conclusions: Early cognitive intervention targeting specifically negative self-referencing process could be considered during pharmacological or rTMS treatment for patients with personality disorders and past history of suicide attempt. (shrink)

At the beginning of the twentieth century, G. E. Moore’s open question argument convinced many philosophers that moral statements were not equivalent to statements made using non- moral or descriptive terms. For any non- moral description of an object or object it seemed that competent speakers could without confusion doubt that the action or object was appropriately characterized using moral terms such as ‘good’ or ‘right’. The question of whether the action or object so described was good or right was (...) always open, even to competent speakers. In the absence of any systematic theory to explain the possibility of synthetic as opposed to analytic identities, many were convinced this demonstrated that moral properties could not be identified with any natural properties. Thus Moore and others concluded that moral properties such as goodness were irreducible sui generis properties, not identical to natural. (shrink)

According to the eligibility theory of meaning, often attributed to David Lewis, the referent of a predicate is the property that best balances the twin constraints of charity and eligibility, where eligibility is a function of metaphysical naturalness. This sort of metasemantics, which is motivated by its ability to resolve problems of indeterminacy and secure shared reference between disputing parties, can be somewhat friendly towards revisionary theories, since highly natural properties can act as “reference magnets,” securing our (...) reference despite some mismatch with usage. In this paper, I apply these considerations to normative ethics and argue that the theory of rule utilitarianism achieves a high balance of charity and eligibility. I proceed by comparing rule utilitarianism to two of its well-known rivals, act utilitarianism and Rossian pluralism. I show how the former achieves a high degree of eligibility but only at a significant cost of charity, while the latter does the opposite, fitting very nicely with our considered judgments but at the price of very low eligibility. Rule utilitarianism, on the other hand, strikes a good balance between these extremes; it assigns to our core moral term a relatively natural property without doing too much damage to our moral convictions. Thus, rule utilitarianism should be regarded as a promising moral theory by any philosopher who takes seriously considerations of eligibility and naturalness. (shrink)

At the beginning of the twentieth century, G. E. Moore’s open question argument convinced many philosophers that moral statements were not equivalent to statements made using non- moral or descriptive terms. For any non- moral description of an object or object it seemed that competent speakers could without confusion doubt that the action or object was appropriately characterized using moral terms such as ‘good’ or ‘right’. The question of whether the action or object so described was good or right was (...) always open, even to competent speakers. In the absence of any systematic theory to explain the possibility of synthetic as opposed to analytic identities, many were convinced this demonstrated that moral properties could not be identified with any natural properties. Thus Moore and others concluded that moral properties such as goodness were irreducible sui generis properties, not identical to natural. (shrink)

In this paper I sketch a novel interpretationist account of linguistic content that has important consequences for thinking about intentionality. I solve the challenge presented by a foundational indeterminacy of reference argument to the effect that the meaning of linguistic expressions is radically indeterminate. Happily, my solution doesn’t require positing natural properties as “reference magnets”. Non-deflationist rivals to interpretationist metasemantics include various kinds of causal theories such as Fodor-style asymmetric-dependence accounts and Millikan-style teleosemantics. These accounts face their (...) own indeterminacy challenges that have yet to be solved, as well as similar indeterminacy of reference challenges at the level of individual words. Moreover, they must contend with our apparent reference to things that we are not plausibly causally acquainted with. If indeterminacy of reference arguments can be answered and we can avoid dubious use of natural properties, an interpretationist account like my own will be the strongest contender.. (shrink)

Phenomenal intentionality is irreducible. Empirical investigation shows it is internally-dependent. So our usual externalist (causal, etc.) theories do not apply here. Internalist views of phenomenal intentionality (e. g. interpretationism) also fail. The resulting primitivist view avoids Papineau’s worry that terms for consciousness are highly indeterminate: since conscious properties are extremely natural (despite having unnatural supervenience bases) they are ’reference magnets’.

Phenomenal intentionality is irreducible. Empirical investigation shows it is internally-dependent. So our usual externalist (causal, etc.) theories do not apply here. Internalist views of phenomenal intentionality (e. g. interpretationism) also fail. The resulting primitivist view avoids Papineau's worry that terms for consciousness are highly indeterminate: since conscious properties are extremely natural (despite having unnatural supervenience bases) they are 'reference magnets'.

The general thesis of this paper is that metasemantic theories can play a central role in determining the correct solution to the liar paradox. I argue for the thesis by providing a specific example. I show how Lewis’s reference-magnetic metasemantic theory may decide between two of the most influential solutions to the liar paradox: Kripke’s minimal fixed point theory of truth and Gupta and Belnap’s revision theory of truth. In particular, I suggest that Lewis’s metasemantic theory favours Kripke’s solution (...) to the paradox over Gupta and Belnap’s. I then sketch how other standard criteria for assessing solutions to the liar paradox, such as whether a solution faces a so-called revenge paradox, fit into this picture. While the discussion of the specific example is itself important, the underlying lesson is that we have an unused strategy for resolving one of the hardest problems in philosophy. (shrink)

Rationalism offers an account of moral properties as a subset of the properties which serve to rationalize right actions, and these properties are fit to be the referents of our moral terms. That fitness can be exploited in constructing an externalist theory of reference determination for these terms. The resulting externalist theory draws support from standard responses to Moral Twin-Earth scenarios. The relevance of these responses to moral semantics has recently beenvigorously challenged by Dowell and by Schroeter and Schroeter. (...) The social character of meaning relations, which can explain the openness of questions about an analysis, may thereby also make Twin-Earth judgements beside the point. But the resources available to translators go beyond semantic competence and it is these resources that nonetheless make the Moral Twin-Earth responses relevant. (shrink)

The perfectly natural properties and relations are special—they are all and only those that "carve nature at its joints." They act as reference magnets, form a minimal supervenience base, figure in fundamental physics and in the laws of nature, and never divide duplicates within or between worlds. If the perfectly natural properties are the (metaphysically) important ones, we should expect being a perfectly natural property to itself be one of the (perfectly) natural properties. This paper argues that being (...) a perfectly natural property is not a very natural property, and examines the consequences. (shrink)

Background: Magnetic resonance spectroscopic imaging is a neuroimaging technique that may be useful for non-invasive mapping of brain temperature over a large brain volume. To date, intra-subject reproducibility of MRSI-based brain temperature has not been investigated. The objective of this repeated measures MRSI-t study was to establish intra-subject reproducibility and repeatability of brain temperature, as well as typical brain temperature range.Methods: Healthy participants aged 23–46 years were scanned at two time points ~12-weeks apart. Volumetric MRSI data were processed by reconstructing (...) metabolite and water images using parametric spectral analysis. Brain temperature was derived using the frequency difference between water and creatine for 47 regions of interest delineated by the modified Automated Anatomical Labeling atlas. Reproducibility was measured using the coefficient of variation for repeated measures, and repeatability was determined using the standard error of measurement. For each region, the upper and lower bounds of Minimal Detectable Change were established to characterize the typical range of TCRE values.Results: The mean global brain temperature over all subjects was 37.2°C with spatial variations across ROIs. There was a significant main effect for time [F = 37.0, p < 0.0001] and for brain region [F = 2.66, p < 0.0001]. The time*brain region interaction was not significant [F = 0.80, p = 0.83]. Participants' TCRE was stable for each ROI across both time points, with ROIs' COVrep ranging from 0.81 to 3.08% ; majority of ROIs had a COVrep <2.0%.Conclusions: Brain temperature measurements were highly consistent between both time points, indicating high reproducibility and repeatability of MRSI-t. MRSI-t may be a promising diagnostic, prognostic, and therapeutic tool for non-invasively monitoring brain temperature changes in health and disease. However, further studies of healthy participants with larger sample size and numerous repeated acquisitions are imperative for establishing a reference range of typical brain TCRE, as well as the threshold above which TCRE is likely pathological. (shrink)

Epistemicism is one of the main approaches to the phenomenon of vagueness. But how does it fare in its treatment of_ moral_ vagueness? This paper has two goals. First, I shall explain why various recent arguments against an epistemicist approach to moral vagueness are unsuccessful. Second, I shall explain how, in my view, reflection on the Sorites can inform normative ethics in powerful and interesting ways. In this connection, I shall be putting the epistemicist treatment to work, engaging with a (...) family of somewhat neglected issues concerning continuity that lie at the interface of metaphysics and ethics. (shrink)

Introduction: Motor evoked potentials (MEPs) to transcranial magnetic stimulation are known to be susceptible to several sources of variability. However, conflicting evidences on individual characteristics in relatively small sample sizes have been reported. We investigated the effect of age, height, and sex on MEPs of the motor cortex and spinal roots in a large cohort. Methods: A total of 587 subjects clinically and neuroradiologically intact were included. MEPs were recorded during mild tonic contraction through a circular coil applied over the (...) “hot spot” of the first dorsal interosseous and tibialis anterior muscles, bilaterally. Central motor conduction time (CMCT) was estimated as the difference between MEP cortical latency and the peripheral motor conduction time by cervical or lumbar magnetic stimulation. Peak-to-peak MEP amplitude to cortical stimulation and right-to-left difference of each parameter were also measured. Results: After Bonferroni correction, general linear (multiple) regression analysis showed that both MEP cortical latency and peripheral motor conduction time at four limbs positively correlated with age and height. At lower limbs, an independent effect of sex on the same measures was also observed (with females showing smaller values than males). CMCT correlated with both age (negatively) and height (positively) when analyzed by a single regression; however, with a multiple regression analysis this significance disappeared, due to the correction for the multicollinearity within the dataset. Conclusions: Physical individual features need to be considered for a more accurate and meaningful MEPs interpretation. Both in clinical practice and in research setting, patients and controls should be matched for age, height, and sex. (shrink)

DNA extraction, playing an irreplaceable role in molecular biology as it is an essential step prior to various downstream biological analyses. Thus, the accuracy and reliability of downstream research outcomes depend largely on upstream DNA extraction methodology. However, with the advancement of downstream DNA detection techniques, the development of corresponding DNA extraction methods is lagging behind. The most innovative DNA extraction techniques are silica‐ or magnetic‐based. Recent studies have demonstrated that plant fiber‐based adsorbents (PF‐BAs) have stronger DNA capturing ability than (...) classic materials. Moreover, magnetic ionic liquid (MIL)‐based DNA extraction has gathered attention lately, and extrachromosomal circular DNA (eccDNA), cell‐free DNA (cfDNA), and microbial community DNA are current research hotspots. These require specific extraction methods, along with constant improvements in the way they are used. This review discusses the significance as well as the direction of innovation of DNA extraction methods to try to provide valuable references including current status and trends for DNA extraction. (shrink)

Psychophysical experiments have demonstrated large and highly systematic perceptual distortions of tactile space. Such a space can be referred to our experience of the spatial organisation of objects, at representational level, through touch, in analogy with the familiar concept of visual space. We investigated the neural basis of tactile space by analysing activity patterns induced by tactile stimulation of nine points on a 3 × 3 square grid on the hand dorsum using functional magnetic resonance imaging. We used a searchlight (...) approach within pre-defined regions of interests to compute the pairwise Euclidean distances between the activity patterns elicited by tactile stimulation. Then, we used multidimensional scaling to reconstruct tactile space at the neural level and compare it with skin space at the perceptual level. Our reconstructions of the shape of skin space in contralateral primary somatosensory and motor cortices reveal that it is distorted in a way that matches the perceptual shape of skin space. This suggests that early sensorimotor areas critically contribute to the distorted internal representation of tactile space on the hand dorsum. (shrink)

Derived from Heidegger's interpretation of attractive force with a high volume of inspired beauty care and a master not only the followers. And in order to maintain this special, he followed the great classical psychologists: Ferdinand learning. He also won in the traditional school psychology professor at the certificate, but his real motive is not subject to the ancient hope臘Heidegger was carried out by the interpretation of the full amount of impact force. Nevertheless, Heidegger's classic is still up to the (...) United States: "true management and methods" to maintain significant influence over. Up to the United States as a major interpreter of Heidegger's thinking, and faithful friend. In about two more people, I turned to introduce three other in Heidegger, Gadamer's major research on the influence of the philosopher: Park Latin chart, sub-km Aristotle and Hegel. First we look at the future Park Latin chart, I think the focus on conversation and dialogue up to the United States and the "dialectic dialogue" concept. The relative importance of making it true, so true that people with reasonable doubt and dialogue. Although there are many plans to pull up to the United States Park effect, but I make up as two points and a U.S. interlocutor's talent and try to prove. I have given up by the United States with three coming from Aristotle's concept of sub-km: wise , mimetic and tragedy. Wise is to predict the results of practical wisdom for the rational, he does not see a formula-based learning, as can be, but based on life experience. That mimic the Department of Aristotle in the sub-km only copy, and is reasonable in real life, the ultimate communicator. Finally, the tragedy is not the only sub-km Aristotle considers the six parts of the structure, but compassion and fear the experience of change in the audience angle of view, it is up to the United States in view of the viewer's experience of understanding and application, is a kind of tragedy action meaningful participation and experience. Beneficiary of up to U.S. history in Hegel's awareness of personal, Hegel's dialectic, as well as their knowledge to the arts is the current acceptance of the senses. He does not agree with Hegel referred to the "art of the past things," Hegel explains how this point. Shortly we will be able to see the remarkable work of art as a nervous balcony. Let me give you a visit in Heidelberg, Heidegger's experience in the United States up to the lecture, he objected to clarify and to hide his own dialectic and Hegel's dialectic with links, because at the end of Hegel's philosophy of total abstraction knowledge. In the second part of this lecture, I turned to the analysis of Gadamer's thesis on the art of "the relevance of the United States," and Heidegger in this direction is the famous "Art works of origin> thesis compared. In the late writings, Heidegger shows that there is not his main independent and self-study will be presented in the art of the earth and the world as a tension. In Gadamer's thesis in art, he follows Heidegger in the hope臘by establishing the art of human culture, learn the origin of works of art ontology analysis. He discussed all the cultural roots of the game , the difference between symbolic meaning and religious ceremonies. But he formed an art theory of the problem to analyze, it also clarifies the classical art and contemporary abstract art. In these three elements: the game, symbols and festivals, art up to the United States to find a structure is more deep cultural roots. As in the early hope臘ceremony, dance performances and tragedy. Gadamer's encounter with the magnetic force of Heidegger's interpretations made him cautious not to become simply a follower of the great master. To maintain his independence, he studied with Paul Friedländer, the great classical philologist. He attained certification in classical philology to teach in the secondary schools, but his true motive was to be able to resist the powerful interpretations of Greek philosophy put forward by Heidegger. Nevertheless, Heidegger remained a major leavening influence on Gadamer's classic, Truth and Method, and Gadamer became a major interpreter of Heidegger's thought, and a constant friend. After a few comparisons between them, I turn to three major philosophers other than Heidegger who contributed concepts to Gadamer's masterwork: Plato, Aristotle, and Hegel. Regarding Plato, I point to the emphasis in Gadamer on dialogue and conversation and the concept of eumeneis elenchoi, the respect the opponent that recognizes that he could be right, so they join together in dialogue in quest of the truth. Although there are many other debts to Plato in Gadamer, I point to these two and testify to Gadamer's gifts as a conversationalist and debater. I single out three concepts of Aristotle that Gadamer used: phronesis, mimesis, and tragedy. Phronesis is the practical wisdom that goes beyond calculative reason. It is based not on formulas that can be learned but on experience of life . Mimesis in Aristotle is not just copying, but on a recognition that ultimately conveyed truth about life. Finally, tragedy for Aristotle is not just a structure with six parts but an experience of pity and terror that transformed the perspective of the viewer. This was important in the hermeneutics of Gadamer that looked at the viewer's experience of recognition and application, a participatory experience of the meaning of the action of the tragedy. Gadamer is indebted to Hegel for the historical character of consciousness, the Hegelian dialectic, and the recognition that that art is a sensuous representation of the real. He did not agree with Hegel that art was a thing of the past, and also explained what Hegel meant by this: we no longer saw art as a disclosure of the divine. I mention an experience I had of Heidegger's visit to Heidelberg, where he spoke after Gadamer's lecture rejecting his effort to connect his dialect of clearing and concealing with Hegelian dialectic, because Hegel's philosophy always ended in absolute knowledge. For the second major part of the lecture, I turn to an analysis of Gadamer's essay on art, The Relevance of the Beautiful , comparable in a way to Heidegger's famous lectures on The Origin of the Work of Art . In the latter work, Heidegger declares his independence of his masterwork and presents art in terms of the tension between earth and world. In Gadamer's essay on art, he goes beyond the Heideggerian emphasis on the ontology of the artwork by seeking to establish the anthropological roots of art in Greek culture. He discusses the roots of all culture in play, the significance of the symbol, and the meaning of religious festivals. But he begins with an analysis of the problem of formulating a theory of art that does justice both to classical art and contemporary nonrepresentational art. In all three elements, play, symbol, and festival, Gadamer finds a foundation for art in the deep roots of our culture as found in the ritual, dance, and tragic plays of ancient Greece. (shrink)

Optic neuropathy refers to disease of the optic nerve and can result in loss of visual acuity and/or visual field defects. Combining findings from multiple fMRI modalities can offer valuable information for characterizing and managing optic neuropathies. In this article, we review a subset of resting-state functional magnetic resonance imaging (RS-fMRI) studies of optic neuropathies. We consider glaucoma, acute optic neuritis (ON), discuss traumatic optic neuropathy (TON), and explore consistency between findings from RS and visually driven fMRI studies. Consistent with (...) visually driven studies, glaucoma studies at rest also indicated reduced activation in the visual cortex and dorsal visual stream. RS-fMRI further reported varying levels of functional connectivity in the ventral stream depending on disease severity. ON patients show alterations within the visual cortex in both fMRI techniques. Particularly, higher-than-normal RS activity is observed in the acute phase and decreases as the disease progresses. A similar pattern is observed in the visual cortex of TON-like, open globe injury (OGI), patients. Additionally, visually driven and RS-fMRI studies of ON patients show recovery of brain activity in the visual cortex. RS-fMRI suggests recovery of signals in higher-tier visual areas MT and LOC as well. Finally, RS-fMRI has not yet been applied to TON, although reviewing OGI studies suggests that it is feasible. Future RS-fMRI studies of optic neuropathies could prioritize studying the fine scale RS activity of brain areas that visually driven studies have identified. We suggest that a more systematic longitudinal comparison of optic neuropathies with advanced fMRI would provide improved diagnostic and prognostic information. (shrink)

With the help of syncretiсs as a new philosophical logic, the philosophy of carriers, the theory of similarity and the theory of Infinite Hierarchical Nesting of Matter, the problems of modern physics are analyzed. We consider the classical and relativistic mechanics, the special and general theories of relativity, the theory of electromagnetic and gravitational fields, of weak and strong interactions. The goal is axiomatization of these theories, building models of elementary particles and of their interactions with each other. The main (...) obtained results are: description of the electrokinetic theory of the origin of magnetic fields in cosmic bodies; calculation of metric in the uniformly accelerated reference frame; the axiomatic construction of electrodynamics, Lorentz invariant (LITG) and covariant theories of gravitation (CTG); comparing CTG with the general theory of relativity and with the results of gravitational experiments. Among other results – the analysis of the properties of ether as the medium responsible for transfer of electromagnetic and gravitational waves, and derivation of the formula for entropy in a tensor form. For students and researchers, as well as for those interested in physical and philosophical problems. (shrink)

ABSTRACT I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments. INTRODUCTION In contrast to the classic model of randomized-control trials, often with a large number of (...) subjects enrolled, precision medicine attempts to optimize therapeutic outcomes by focusing on the individual.[i] A recent publication highlights the strengths and weakness of both traditional evidence-based medicine and precision medicine.[ii] Plus, it outlines a tension in the shift from evidence-based medicine’s inductive reasoning style (the collection of data to postulate general theories) to precision medicine’s abductive reasoning style (the generation of an idea from the limited data available).[iii] The paper’s main example is the application of precision medicine for the treatment of cancer.[iv] I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. As the name suggests, brain-computer interfaces are a significant advancement in neurotechnology that directly connects someone’s brain to external or implanted devices.[v] Among the various kinds of brain-computer interfaces, adaptive deep brain stimulation devices require numerous personalized adjustments to their settings during the implantation and computation stages in order to provide adequate relief to patients with treatment-resistant disorders. What makes these devices unique is how adaptive deep brain stimulation integrates a sensory component to initiate the stimulation. While not commonly at the level of sophistication as self-supervising or generative large language models,[vi] they currently allow for a semi-autonomous form of neuromodulation. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments.[vii] ANALYSIS I. The State of Precision Medicine in Oncology and the Epistemological Shift While a thorough overview of precision medicine for the treatment of cancer is beyond the scope of this article, its practice can be roughly summarized as identifying clinically significant characteristics a patient possesses (e.g., genetic traits) to land on a specialized treatment option that, theoretically, should benefit the patient the most.[viii] However, in such a practice of stratification patients fall into smaller and smaller populations and the quality of evidence that can be applied to anyone outside these decreases in turn.[ix] As inductive logic helps to articulate, the greater the number of patients that respond to a particular therapy the higher the probability of its efficacy. By straying from this logical framework, precision medicine opens the treatment of cancer to more uncertainty about the validity of these approaches to the resulting disease subcategories.[x] Thus, while contemporary medical practices explicitly describe some treatments as “personalized”, they ought not be viewed as inherently better founded than other therapies.[xi] A relevant contemporary case of precision medicine out of Norway focuses on the care of a patient with cancer between the ventricles of the heart and esophagus, which had failed to respond to the standard regimen of therapies over four years.[xii] In a last-ditch effort, the patient elected to pay out-of-pocket for an experimental immunotherapy (nivolumab) at a private hospital. He experienced marked improvements and a reduction in the size of the tumor. Understandably, the patient tried to pursue further rounds of nivolumab at a public hospital. However, the hospital initially declined to pay for it given the “lack of evidence from randomised clinical trials for this drug relating to this [patient’s] condition.”[xiii] In rebuttal to this claim, the patient countered that he was actually similar to a subpopulation of patients who responded in “open‐label, single arm, phase 2 studies on another immune therapy drug” (pembrolizumab).[xiv] Given this interpretation of the prior studies and the patient’s response, further rounds of nivolumab were approved. Had the patient not had improvements in the tumor’s size following a round of nivolumab, then pembrolizumab’s prior empirical evidence in isolation would have been insufficient, inductively speaking, to justify his continued use of nivolumab.[xv] The case demonstrates a shift in reasoning from the traditional induction to abduction. The phenomenon of ‘cancer improvement’ is considered causally linked to nivolumab and its underlying physiological mechanisms.[xvi] However, “the weakness of abductions is that there may always be some other better, unknown explanation for an effect. The patient may for example belong to a special subgroup that spontaneously improves, or the change may be a placebo effect. This does not mean, however, that abductive inferences cannot be strong or reasonable, in the sense that they can make a conclusion probable.”[xvii] To demonstrate the limitations of relying on the abductive standard in isolation, commentators have pointed out that side effects in precision medicine are hard to rule out as being related to the initial intervention itself unless trends from a group of patients are taken into consideration.[xviii] As artificial intelligence (AI) assists the development of precision medicine for oncology, this uncertainty ought to be taken into consideration. The implementation of AI has been crucial to the development of precision medicine by providing a way to combine large patient datasets or a single patient with a large number of unique variables with machine learning to recommend matches based on statistics and probability of success upon which practitioners can base medical recommendations.[xix] The AI is usually not establishing a causal relationship[xx] – it is predicting. So, as AI bleeds into medical devices, like brain-computer interfaces, the same cautions about using abductive reasoning alone should be carried over. II. Responsive Neurostimulation, AI, and Personalized Medicine Like precision medicine in cancer treatment, computer-brain interface technology similarly focuses on the individual patient through personalized settings. In order to properly expose the intersection of AI, precision medicine, abductive reasoning, and implantable neurotechnologies, the descriptions of adaptive deep brain stimulation systems need to deepen.[xxi] As a broad summary of adaptive deep brain stimulation, to provide a patient with the therapeutic stimulation, a neural signal, typically referred to as a local field potential,[xxii] must first be detected and then interpreted by the device. The main adaptive deep brain stimulation device with premarket approval, the NeuroPace Responsive Neurostimulation system, is used to treat epilepsy by detecting and storing “programmer-defined phenomena.”[xxiii] Providers can optimize the detection settings of the device to align with the patient’s unique electrographic seizures as well as personalize the reacting stimulation’s parameters.[xxiv] The provider adjusts the technology based on trial and error. One day machine learning algorithms will be able to regularly aid this process in myriad ways, such as by identifying the specific stimulation settings a patient may respond to ahead of time based on their electrophysiological signatures.[xxv] Either way, with AI or programmers, adaptive neurostimulation technologies are individualized and therefore operate in line with precision medicine rather than standard treatments based on large clinical trials. Contemporary neurostimulation devices are not usually sophisticated enough to be prominent in AI discussions where the topics of neural networks, deep learning, generative models, and self-attention dominate the conversation. However, implantable high-density electrocorticography arrays (a much more sensitive version than adaptive deep brain stimulation systems use) have been used in combination with neural networks to help patients with neurologic deficits from a prior stroke “speak” through a virtual avatar.[xxvi] In some experimental situations, algorithms are optimizing stimulation parameters with increasing levels of independence.[xxvii] An example of neurostimulation that is analogous to the use of nivolumab in Norway surrounds a patient in the United States who was experiencing both treatment-resistant OCD and temporal lobe epilepsy.[xxviii]Given the refractory nature of her epilepsy, implantation of an adaptive deep brain stimulation system was indicated. As a form of experimental therapy, her treatment-resistant OCD was also indicated for the off-label use of an adaptive deep brain stimulation set-up. Another deep brain stimulation lead, other than the one implanted for epilepsy, was placed in the patient’s right nucleus accumbens and ventral pallidum region given the correlation these nuclei had with OCD symptoms in prior research. Following this, the patient underwent “1) ambulatory, patient-initiated magnet-swipe storage of data during moments of obsessive thoughts; (2) lab-based, naturalistic provocation of OCD-related distress (naturalistic provocation task); and (3) lab-based, VR [virtual reality] provocation of OCD-related distress (VR provocation task).”[xxix] Such signals were used to identify when to deliver the therapeutic stimulation in order to counter the OCD symptoms. Thankfully, following the procedure and calibration the patient exhibited marked improvements in their OCD symptoms and recently shared her results publicly.[xxx] In both cases, there is a similar level of abductive justification for the efficacy of the delivered therapy. In the case study in which the patient was treated with adaptive deep brain stimulation, they at least had their neural activity tested in various settings to determine the optimum parameters for treatment to avoid them being based on guesswork. Additionally, the adaptive deep brain stimulation lead was already placed before the calibration trials were conducted, meaning that the patient had already taken on the bulk of the procedural risk before the efficacy could be determined. Such an efficacy test could have been replicated in the first patient’s cancer treatment, had it been biopsied and tested against the remaining immunotherapies in vitro. Yet, in the case of cancer with few options, one previous dose of a drug that appeared to work on the patient may justify further doses. However, as the Norwegian case presents, corroboration with known responses to a similar drug (from a clinical trial) could be helpful to validate the treatment strategy. (It should be noted that both patients were resigned to these last resort options regardless of the efficacy of treatment.) There are some elements of inductive logic seen with adaptive deep brain stimulation research in general. For example, abductively the focus could be that patient X’s stimulation parameters are different from patient Y’s and patient Z’s. In contrast, when grouped as subjects who obtained personalized stimulation, patients X, Y, and Z demonstrate an inductive aspect to this approach’s safety and/or efficacy. The OCD case holds plenty of abductive characteristics in line with precision medicine’s approach to treating cancer and as more individuals try the method, there will be additional data. With the gradual integration of AI into brain-computer interfaces in the name of efficacy, this reliance on abduction will continue, if not grow, over time. Moving forward, if a responsive deep brain stimulation treatment is novel and individualized (like the dose of nivolumab) and there is some other suggestion of efficacy (like clinical similarities to other patients in the literature), then it may justify insurance coverage for the investigative intervention, absent other unrelated reasons to deny it. III. Ethical Implications and Next Steps While AI’s use in oncology and neurology is not yet as prominent as its use in other fields (e.g., radiology), it appears to be on the horizon for both.[xxxi] AI can be found in both the functioning of the neurotechnologies as well as the implementation of precision medicine. The increasing use of AI may serve to further individualize both oncologic and neurological therapies. Given these implications and the handful of publications cited in this article, it is important to have a nuanced evaluation of how these treatments, which heavily rely on abductive justification, ought to be managed. The just use an abductive approach may be difficult as AI infused precision medicine is further pursued. At baseline, such technology relies on a level of advanced technology literacy among the general public and could exclude populations who lack access to basic technological infrastructure or know-how from participation.[xxxii] Even among nations with adequate infrastructure, as more patients seek out implantable neurotechnologies, which require robust healthcare resources, the market will favor patient populations that can afford this complex care.[xxxiii] If patients already have the means to pay for an initial dose/use of a precision medicine product out of pocket, should insurance providers be required to cover subsequent treatments?[xxxiv] That is, if a first dose of a cancer drug or a deep brain stimulator over its initial battery life is successful, patients may feel justified in having the costs of further treatments covered. The Norwegian patient’s experience implies there is a precedent for the idea that some public insurance companies ought to cover successful cancer therapies, however, insurance companies may not all see themselves as obligated to cover neurotechnologies that rely on personalized settings or that are based on precision/abductive research more than on clinical trials. CONCLUSION The fact that the cases outlined above rely on abductive style of reasoning implies that there may not be as strong a justification for coverage by insurance, as they are both experimental and individualized, when compared to the more traditional large clinical trials in which groups have the same or a standardized protocol (settings/doses). If a study is examining the efficacy of a treatment with a large cohort of patients or with different experimental groups/phases, insurance companies may conclude that the resulting symptom improvements are more likely to be coming from the devices themselves. A preference for inductive justification may take priority when ruling in favor of funding someone’s continued use of an implantable neurostimulator. There are further nuances to this discussion surrounding the classifications of these interventions as research versus clinical care that warrant future exploration, since such a distinction is more of a scale[xxxv] than binary and could have significant impacts on the “right-to-try” approach to experimental therapies in the United States.[xxxvi] Namely, given the inherent limitations of conducting large cohort trials for deep brain stimulation interventions on patients with neuropsychiatric disorders, surgically innovative frameworks that blend abductive and inductive methodologies, like with sham stimulation phases, have traditionally been used.[xxxvii] Similarly, for adaptive brain-computer interface systems, if there are no large clinical trials and instead only publications that demonstrate that something similar worked for someone else, then, in addition to the evidence that the first treatment/dose worked for the patient in question, the balance of reasoning would be valid and arguably justify insurance coverage. As precision approaches to neurotechnology become more common, frameworks for evaluating efficacy will be crucial both for insurance coverage and for clinical decision making. ACKNOWLEDGEMENT This article was originally written as an assignment for Dr. Francis Shen’s “Bioethics & AI” course at Harvard’s Center for Bioethics. I would like to thank Dr. Shen for his comments as well as my colleagues in the Lázaro-Muñoz Lab for their feedback. - [i] Jonathan Kimmelman and Ian Tannock, “The Paradox of Precision Medicine,” Nature Reviews. Clinical Oncology 15, no. 6 (June 2018): 341–42, https://doi.org/10.1038/s41571-018-0016-0. [ii] Henrik Vogt and Bjørn Hofmann, “How Precision Medicine Changes Medical Epistemology: A Formative Case from Norway,” Journal of Evaluation in Clinical Practice 28, no. 6 (December 2022): 1205–12, https://doi.org/10.1111/jep.13649. [iii] David Barrett and Ahtisham Younas, “Induction, Deduction and Abduction,” Evidence-Based Nursing 27, no. 1 (January 1, 2024): 6–7, https://doi.org/10.1136/ebnurs-2023-103873. [iv] Vogt and Hofmann, “How Precision Medicine Changes Medical Epistemology,” 1208. [v] Wireko Andrew Awuah et al., “Bridging Minds and Machines: The Recent Advances of Brain-Computer Interfaces in Neurological and Neurosurgical Applications,” World Neurosurgery, May 22, 2024, S1878-8750(24)00867-2, https://doi.org/10.1016/j.wneu.2024.05.104. [vi] Mark Riedl, “A Very Gentle Introduction to Large Language Models without the Hype,” Medium (blog), May 25, 2023, https://mark-riedl.medium.com/a-very-gentle-introduction-to-large-language-models-without-the-hype-5 f67941fa59e. [vii] David E. Burdette and Barbara E. Swartz, “Chapter 4 - Responsive Neurostimulation,” in Neurostimulation for Epilepsy, ed. Vikram R. Rao (Academic Press, 2023), 97–132, https://doi.org/10.1016/B978-0-323-91702-5.00002-5. [viii] Kimmelman and Tannock, 2018. [ix] Kimmelman and Tannock, 2018. [x] Simon Lohse, “Mapping Uncertainty in Precision Medicine: A Systematic Scoping Review,” Journal of Evaluation in Clinical Practice 29, no. 3 (April 2023): 554–64, https://doi.org/10.1111/jep.13789. [xi] Kimmelman and Tannock, “The Paradox of Precision Medicine.” [xii] Vogt and Hofmann, 1206. [xiii] Vogt and Hofmann, 1206. [xiv] Vogt and Hofmann, 1206. [xv] Vogt and Hofmann, 1207. [xvi] Vogt and Hofmann, 1207. [xvii] Vogt and Hofmann, 1207. [xviii] Vogt and Hofmann, 1210. [xix] Mehar Sahu et al., “Chapter Three - Artificial Intelligence and Machine Learning in Precision Medicine: A Paradigm Shift in Big Data Analysis,” in Progress in Molecular Biology and Translational Science, ed. David B. Teplow, vol. 190, 1 vols., Precision Medicine (Academic Press, 2022), 57–100, https://doi.org/10.1016/bs.pmbts.2022.03.002. [xx] Stefan Feuerriegel et al., “Causal Machine Learning for Predicting Treatment Outcomes,” Nature Medicine 30, no. 4 (April 2024): 958–68, https://doi.org/10.1038/s41591-024-02902-1. [xxi] Sunderland Baker et al., “Ethical Considerations in Closed Loop Deep Brain Stimulation,” Deep Brain Stimulation 3 (October 1, 2023): 8–15, https://doi.org/10.1016/j.jdbs.2023.11.001. [xxii] David Haslacher et al., “AI for Brain-Computer Interfaces,” 2024, 7, https://doi.org/10.1016/bs.dnb.2024.02.003. [xxiii] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 103–4; “Premarket Approval (PMA),” https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P100026. [xxiv] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 104. [xxv] Burdette and Swartz, 126. [xxvi] Sean L. Metzger et al., “A High-Performance Neuroprosthesis for Speech Decoding and Avatar Control,” Nature 620, no. 7976 (August 2023): 1037–46, https://doi.org/10.1038/s41586-023-06443-4. [xxvii] Hao Fang and Yuxiao Yang, “Predictive Neuromodulation of Cingulo-Frontal Neural Dynamics in Major Depressive Disorder Using a Brain-Computer Interface System: A Simulation Study,” Frontiers in Computational Neuroscience 17 (March 6, 2023), https://doi.org/10.3389/fncom.2023.1119685; Mahsa Malekmohammadi et al., “Kinematic Adaptive Deep Brain Stimulation for Resting Tremor in Parkinson’s Disease,” Movement Disorders 31, no. 3 (2016): 426–28, https://doi.org/10.1002/mds.26482. [xxviii] Young-Hoon Nho et al., “Responsive Deep Brain Stimulation Guided by Ventral Striatal Electrophysiology of Obsession Durably Ameliorates Compulsion,” Neuron 0, no. 0 (October 20, 2023), https://doi.org/10.1016/j.neuron.2023.09.034. [xxix] Nho et al. [xxx] Nho et al.; Erik Robinson, “Brain Implant at OHSU Successfully Controls Both Seizures and OCD,” OHSU News, accessed March 3, 2024, https://news.ohsu.edu/2023/10/25/brain-implant-at-ohsu-successfully-controls-both-seizures-and-ocd. [xxxi] Awuah et al., “Bridging Minds and Machines”; Haslacher et al., “AI for Brain-Computer Interfaces.” [xxxii] Awuah et al., “Bridging Minds and Machines.” [xxxiii] Sara Green, Barbara Prainsack, and Maya Sabatello, “The Roots of (in)Equity in Precision Medicine: Gaps in the Discourse,” Personalized Medicine 21, no. 1 (January 2024): 5–9, https://doi.org/10.2217/pme-2023-0097. [xxxiv] Green, Prainsack, and Sabatello, 7. [xxxv] Robyn Bluhm and Kirstin Borgerson, “An Epistemic Argument for Research-Practice Integration in Medicine,” The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine 43, no. 4 (July 9, 2018): 469–84, https://doi.org/10.1093/jmp/jhy009. [xxxvi] Vijay Mahant, “‘Right-to-Try’ Experimental Drugs: An Overview,” Journal of Translational Medicine 18 (June 23, 2020): 253, https://doi.org/10.1186/s12967-020-02427-4. [xxxvii] Michael S. Okun et al., “Deep Brain Stimulation in the Internal Capsule and Nucleus Accumbens Region: Responses Observed during Active and Sham Programming,” Journal of Neurology, Neurosurgery & Psychiatry 78, no. 3 (March 1, 2007): 310–14, https://doi.org/10.1136/jnnp.2006.095315. (shrink)

David Albert claims that classical electromagnetic theory is not time reversal invariant. He acknowledges that all physics books say that it is, but claims they are ``simply wrong" because they rely on an incorrect account of how the time reversal operator acts on magnetic fields. On that account, electric fields are left intact by the operator, but magnetic fields are inverted. Albert sees no reason for the asymmetric treatment, and insists that neither field should be inverted. I argue, to the (...) contrary, that the inversion of magnetic fields makes good sense and is, in fact, forced by elementary geometric considerations. I also suggest a way of thinking about the time reversal invariance of classical electromagnetic theory -- one that makes use of the invariant (four-dimensional) formulation of the theory -- that makes no reference to magnetic fields at all. It is my hope that it will be of interest in its own right, Albert aside. It has the advantage that it allows for arbitrary curvature in the background spacetime structure, and is therefore suitable for the framework of general relativity. (The only assumption one needs is temporal orientability.). (shrink)

It is known that Maxwell’s electrodynamics—as usually understood at the present time—when applied to moving bodies, leads to asymmetries which do not appear to be inherent in the phenomena. Take, for example, the reciprocal electrodynamic action of a magnet and a conductor. The observable phenomenon here depends only on the relative motion of the conductor and the magnet, whereas the customary view draws a sharp distinction between the two cases in which either the one or the other of these bodies (...) is in motion. For if the magnet is in motion and the conductor at rest, there arises in the neighbourhood of the magnet an electric field with a certain definite energy, producing a current at the places where parts of the conductor are situated. But if the magnet is stationary and the conductor in motion, no electric field arises in the neighbourhood of the magnet. In the conductor, however, we find an electromotive force, to which in itself there is no corresponding energy, but which gives rise—assuming equality of relative motion in the two cases discussed—to electric currents of the same path and intensity as those produced by the electric forces in the former case. Examples of this sort, together with the unsuccessful attempts to discover any motion of the earth relatively to the “light medium,” suggest that the phenomena of electrodynamics as well as of mechanics possess no properties corresponding to the idea of absolute rest. They suggest rather that, as has already been shown to the first order of small quantities, the same laws of electrodynamics and optics will be valid for all frames of reference for which the equations of mechanics hold good.1 We will raise this conjecture (the purport of which will hereafter be called the “Principle of Relativity”) to the status of a postulate, and also introduce another postulate, which is only apparently irreconcilable with the former, namely, that light is always propagated in empty space with a definite velocity c which is independent of the state of motion of the emitting body.. (shrink)

This essay focuses on the ongoing references made to the ban on graven images for the foundation of political aesthetics. In this tradition the image itself plays a significant role in the creation of a dichotomy in which the image becomes either “icon” or false appearance. The image in this tradition is a powerful agent and gains as such performative power. From the Bible to Kant and German idealism to Adorno and Deleuze, the prohibition of the image signals its power (...) and turns it into a strong magnet in political aesthetics, may it be affirmative or negative. (shrink)

What precisely does it mean to unify fields like the electric and magnetic field to only one field? Are there different kinds of unification? Is there only ‘unified’ and ‘not unified’, or could a unififcation of fields also be partially succesful? I will argue that what is normally referred to as the project of a unified field theory is actually a bundle of three research programmes that are logically independent of each other. The sub-programmes are those of a unified field (...) theory, a complete field theory, and a geometrised field theory. Here I will focus on the programme of a unified field theory in a narrow sense. In particular, I will make use of an almost unknown debate between Einstein and Pauli about which criteria a unification of fields should fulfil, in order to distinguish between different degrees of unification in field theories. (shrink)

BackgroundPost-stroke depression is one of the most common neuropsychiatric diseases in patients with stroke, and it can increase the disability rate, mortality, and recurrence rate of stroke. Currently, many clinical studies have indicated that traditional Chinese medicine, such as acupuncture and herbs, Western medicine, rehabilitation, repeated transcranial magnetic stimulation, and other treatment methods, are effective in treating PSD. However, no study has formulated a comprehensive treatment plan that integrates TCM, Western medicine, and rehabilitation for PSD. Thus, this trial aims to (...) assess the efficacy and safety of integrative medicine for treating PSD.MethodsThis multicenter, prospective, randomized, controlled study aims to form a set of effective clinical treatment schemes that integrate TCM, Western medicine, and rehabilitation for PSD. A total of 202 participants recruited from four centers will be randomized into either the integrative medicine or standard care group. Standard care—basic treatment, general nursing care, and exercise therapy—will be provided to all participants. The integrative medicine group will also receive acupuncture, Chinese herbs, and repeated transcranial magnetic stimulation. Participants will receive acupuncture and rTMS treatments five times per week for 4 weeks and will be administered Chinese herbs, basic treatment, general nursing care, and exercise therapy for 4 weeks. The primary outcomes include the Hamilton Depression Scale, Self-Rating Depression Scale, and Activity of Daily Living Scale. And the secondary outcomes include the Montreal Cognitive Assessment Scale, the Fugl-Meyer Assessment Scale, and the Pittsburgh Sleep Quality Index. All outcome measures will be evaluated at baseline, week 4, and week 8. Safety assessments will be performed throughout the study.DiscussionThis study is expected to verify the efficacy and safety of integrative medicine for treating PSD, providing an evidence-based clinical reference for the future development of a standardized scheme.Clinical trial registrationClinicalTrials.gov, identifier: NCT05187975. (shrink)

The article addresses the production of reproducibility as a topic that has become acutely relevant in the recent discussions on the replication crisis in science. It brings the ethnomethodological stance on reproducibility into the discussions, claiming that reproducibility is necessarily produced locally, on the shop floor, with methodological guidelines serving as references to already established practices rather than their origins. The article refers to this argument empirically, analyzing how a group of novice neuroscientists performs a series of measurements in a (...) transcranial magnetic stimulation experiment. Based on ethnography and video analysis, the article traces a history of the local measurement procedure invented by the researchers in order to overcome the experimental uncertainty. The article aims to demonstrate how reproducibility of the local procedure is achieved in the shop floor work of the practitioners and how the procedure becomes normalized and questioned as incorrect in the course of experimental practice. It concludes that the difference between guidelines and practical actions is not problematic per se; what may be problematic is that researchers can be engaged in different working projects described by the same instruction. (shrink)

Background: Maximum safe resection of infiltrative brain tumors in eloquent area is the primary objective in surgical neuro-oncology. This goal can be achieved with direct electrical stimulation to perform a functional mapping of the brain in patients awake intraoperatively. When awake surgery is not possible, we propose a pipeline procedure that combines advanced techniques aiming at performing a dissection that respects the anatomo-functional connectivity of the peritumoral region. This procedure can benefit from intraoperative monitoring with computerized tomography scan and brain (...) shift correction. Associated with this intraoperative monitoring, the additional value of preoperative investigation combining brain mapping by navigated transcranial magnetic stimulation with various neuroimaging modalities has not yet been reported.Case Report: A 42-year-old left-handed man had increased intracranial pressure, left hand muscle deficit, and dysarthria, related to an infiltrative tumor of the right frontal lobe with large mass effect and circumscribed contrast enhancement in motor and premotor cortical areas. Spectroscopy profile and intratumoral calcifications on CT-scan suggested an WHO grade III glioma, later confirmed by histology. The aforementioned surgical procedure was considered, since standard awake surgery was not appropriate for this patient. In preoperative time, nTMS mapping of motor function was performed, combined with magnetic resonance imaging -based tractography reconstruction of 6 neural tracts and resting-state functional MRI connectivity of sensorimotor and language networks. In intraoperative time, DES mapping was performed with motor evoked response recording and tumor resection was optimized using non-rigid image transformation of the preoperative data to iCT data. Image guidance was updated with correction for brain shift and tissue deformation using biomechanical modeling taking into account brain elastic properties. This correction was done at crucial surgical steps, i.e., when tumor bulged through the craniotomy after dura mater opening and when approaching the presumed eloquent brain regions. This procedure allowed a total resection of the tumor region with contrast enhancement as well as a complete regression of IICP and dysarthria. Hand paresis remained stable with no additional deficit. Postoperative nTMS mapping confirmed the good functional outcome.Conclusion: This case report and technical note highlights the value of preoperative functional evaluation by nTMS updated intraoperatively with correction of brain deformation by iCT. This multimodal approach may become the optimized technique of reference for patients with brain tumors in eloquent areas that are unsuitable for awake brain surgery. (shrink)

Digital and analog: What do these terms mean today? The use and meaning of such terms change through time. The analog, in particular, seems to go through various phases of popularity and disuse, its appeal pegged most frequently to nostalgic longings for nontechnical or romantic modes of art and culture. The definition of the digital vacillates as well, its precise definition often eclipsed by a kind of fever-pitched industrial bonanza around the latest technologies and the latest commercial ventures. One common (...) response to the question of the digital is to make reference to things like Twitter, Playstation, or computers in general. Here one might be correct, but only coincidentally, for the basic order of digitality (the digitality of digitality) has not yet been demonstrated through mere denotation. And the second question—the question of the analog—is harder still, with responses often also consisting of mere denotations of things: sound waves, the phonograph needle, magnetic tape, a sundial. At least denotation itself is analogical. This article will aim to define the analog explicitly and argue, perhaps counterintuitively, that the golden age of analog thinking was not a few decades past, prior to the wide-spread adoption of the computer. In fact, the fields of structuralism and poststructuralism that emerged in the middle to late twentieth century, concurrent with the deployment of the digital computer, were characteristically digital, what with their focus on the symbolic order and logical economies. If anything, the golden age of analog is happening today, all around us, as evidenced by the proliferation of characteristically analog concerns: sensation, materiality, experience, affect, ethics, and aesthetics. (shrink)

If the cortex is an associative memory, strongly connected cell assemblies will form when neurons in different cortical areas are frequently active at the same time. The cortical distributions of these assemblies must be a consequence of where in the cortex correlated neuronal activity occurred during learning. An assembly can be considered a functional unit exhibiting activity states such as full activation (“ignition”) after appropriate sensory stimulation (possibly related to perception) and continuous reverberation of excitation within the assembly (a putative (...) memory process). This has implications for cortical topographies and activity dynamics of cell assemblies forming during language acquisition, in particular for those representing words. Cortical topographies of assemblies should be related to aspects of the meaning of the words they represent, and physiological signs of cell assembly ignition should be followed by possible indicators of reverberation. The following postulates are discussed in detail: (1) assemblies representing phonological word forms are strongly lateralized and distributed over perisylvian cortices; (2) assemblies representing highly abstract words such as grammatical function words are also strongly lateralized and restricted to these perisylvian regions; (3) assemblies representing concrete content words include additional neurons in both hemispheres; (4) assemblies representing words referring to visual stimuli include neurons in visual cortices; and (5) assemblies representing words referring to actions include neurons in motor cortices. Two main sources of evidence are used to evaluate these proposals: (a) imaging studies focusing on localizing word processing in the brain, based on stimulus-triggered event-related potentials (ERPs), positron emission tomography (PET), and functional magnetic resonance imaging (fMRI), and (b) studies of the temporal dynamics of fast activity changes in the brain, as revealed by high-frequency responses recorded in the electroencephalogram (EEG) and magnetoencephalogram (MEG). These data provide evidence for processing differences between words and matched meaningless pseudowords, and between word classes, such as concrete content and abstract function words, and words evoking visual or motor associations. There is evidence for early word class-specific spreading of neuronal activity and for equally specific high-frequency responses occurring later. These results support a neurobiological model of language in the Hebbian tradition. Competing large-scale neuronal theories of language are discussed in light of the data summarized. Neurobiological perspectives on the problem of serial order of words in syntactic strings are considered in closing. Key Words: associative learning; cell assembly; cognition; cortex; ERP; EEG; fMRI; language; lexicon; MEG; PET; word category. (shrink)

_Husserl and Other Phenomenologists_ addresses a fundamental question: what is it in the thinking of the founding father of phenomenology, Edmund Husserl, that on the one hand enables the huge variety in the phenomenological discourse and, at the same time, necessitates relying on his phenomenology as a point of departure and an object before which philosophizing is conducted. The contributors to this volume, each with his or her own focus on a specific figure in the phenomenological school vis-à-vis Husserl's thinking, (...) demonstrate that every reference to Husserl is necessarily bound up with modifying his ideas and crossing the boundaries of his phenomenology. In this sense, and given the insight that Husserlian phenomenology is already imbued with the potential modifications and revisions, the post-Husserlian phenomenologies may be included together with Husserl in one so-called ‘Phenomenological Movement’. The discussions in the book open for philosophers and intellectuals a window upon phenomenology, which has been one of the richest and most influential cultural phenomena since its very appearance at the beginning of the twentieth century. The book also conveys the complex interpretive dynamic within which a given framework of ideas becomes a sort of magnetic field, with attracting and repelling forces acting on its participants, and thanks to which the great ideas of modernity maintain their vitality and relevance a hundred years after their first appearance. This book was originally published as a special issue of _The European Legacy: Towards New Paradigms. _. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 62.1 (2001) 99-119 [Access article in PDF] Animism and Empiricism: Copernican Physics and the Origins of William Gilbert's Experimental Method John Henry In the second year of this journal's run, way back in 1941, appeared Edgar Zilsel's classic and still widely cited paper on The Origins of William Gilbert's Experimental Method. 1 Focusing on Gilbert's De magnete of 1600, undoubtedly a seminal text (...) in the history of the experimental method, 2 Zilsel argued that Gilbert borrowed his methodology from elite craftsmen, artisans, and other manual workers involved in mining, smelting, smithing, compass making, navigation, sailing, and other activities which involved working with iron or with magnets. 3 On its appearance the paper contributed to a growing and still continuing debate in the history of science about the relative importance of scholars and craftsmen in the origins of modern science. Although Zilsel's general thesis has been critically evaluated in terms of that wider debate, 4 his very specific claims about the [End Page 99] role of elite craftsmen in providing Gilbert with a ready-made experimental method, have never been properly considered. This paper attempts to reassess Zilsel's claims about the origin of Gilbert's experimental method and, in so doing, to arrive at a richer understanding of what Gilbert was trying to do in De magnete and to suggest an alternative source for his experimentalism.The first thing to note about Zilsel's argument is that it had two strands. 5 One of these pointed to actual experimental techniques used by Gilbert and showed that they can all be found in earlier writings on magnets. To be more specific, the techniques in question are to be found either in the thirteenth-century "Letter on the Magnet" written by Petrus Pergrinus or Pierre de Maricourt, first published in 1558, or in The Newe Attractive, a work on the magnetic compass written by a retired mariner, Robert Norman, first published in 1581 but reprinted three times before 1600. 6 The second strand did not involve experiments at all, with one notable exception, but simply implied or suggested that Gilbert's experimental techniques must have been inspired by miners and foundrymen, or navigators and instrument makers. The problem here, as others have objected, 7 is that it is by no means clear that elite craftsmen were engaged in performing experiments in anything like the sense of the word required for the argument to cut any ice. For Zilsel, however, "we cannot doubt that many of [the miners and foundrymen of the period], stimulated to improvements by economic competition, were wont to try new techniques and to observe natural processes." 8 A few sentences later we are told that it is "obvious" that "among such manual labourers there were experimentalists, though experimentalists with practical aims only and without theoretical knowledge." 9 [End Page 100]The philosopher of science at this point might legitimately want to suggest that an experiment is not an experiment unless it is testing a theory, but we do not have to enter into such arguable niceties. 10 We can see that there is something profoundly tendentious in Zilsel's claims simply by reading on. At this point Zilsel mentioned the only experiment specifically referred to in this strand of his argumentation. Quoting Gilbert, Zilsel showed that Gilbert himself must have descended into a mine in order, as Zilsel says, "to verify the hypothesis" that the polarity of a magnet derives from the polarity of the earth: We had a twenty pounds' heavy loadstone dug and hauled out after having first observed and marked its ends in its vein. Then we put the stone in a wooden tub on water, so that it could turn freely. Immediately the surface which had looked to the North in the mine turned itself to the North on the water. 11Zilsel did not make the absurd claim that Gilbert must have seen miners doing this kind of experiment, but he did all he could to... (shrink)

This bibliographical review of the modelling of the mitotic apparatus covers a period of one hundred and twenty years, from the discovery of the bipolar mitotic spindle up to the present day. Without attempting to be fully comprehensive, it will describe the evolution of the main ideas that have left their mark on a century of experimental and theoretical research. Fol and Bütschli's first writings date back to 1873, at a time when Schleiden and Schwann's cell theory was rapidly gaining (...) ground throughout Germany. Both mitosis and chromosomes were to be discovered within the space of thirty years, along with the two key events in the animal and plant reproductive cycle, namely fecondation and meiosis. The mitotic pole, a term still in use to this day, was employed to describe a morphological fact which was noted as early as 1876, namely that the lines and the dots of the karyokinetic figure, with its spindle and asters, looks remarkably like the lines of force around a bar magnet. This was to lead to models designed to explain the movements of chromosomes which take place when the cell nucleus appears to cease to exist as an organelle during mitosis. The nature of those mechanisms and the origin of the forces behind the chromosomes' ordered movements were central to the debate. Auguste Prenant, in a remarkable bibliographical synthesis published in 1910, summed up the opposing viewpoints of the vitalists, on the one hand, who favoured the theory of contractility or extensility in spindle fibres, and of those who believed in models based on physical phenomena, on the other. The latter subdivided into two groups: some, like Bütschli, Rhumbler or Leduc, referred to diffusion, osmosis and superficial tension, whilst the others, led by Gallardo and Hartog, focussed on the laws of electromagnetism. Lillie, Kuwada and Darlington followed up this line of research. The mid-20th century was a major turning point. Most of the modelling mentioned above was criticized and fell into disuse after disappearing from research publications and textbooks.This marked the onset of a new era, as electron microscopes made possible the materialization and detailed study of the macromolecular elements of the fibres, filaments and microtubules of the cytoskeleton. The successive phases of (a) de Harven and Bernhard's 1956 discovery of the centriole's ultrastructure, (b) its identification with the basal body of the cilia and flagella, confirming the theory set out by Henneguy and von Lenhossek (1898–99), (c) the universal presence of microtubules in animal, vegetal and eukaryotic protist cells, (d) the polymerization-depolymerization induced reversible transformations of the tubulin pool in mitosing cells (Inoue, 1960), (e) ultrastructural comparative studies of the mitotic apparatus of eukaryotes illustrating the Pickett-Heaps integrating concept of the MTOC (microtubule-organizing centre), (f) the possibility ofin vitro experiments on mtocs or on microtubules, brings us upon the present day, which has seen the focus placed on the concept of motor-proteins (kinesin, dynein) and on cell cycle models. The latter are based on a close coincidence between the observable modifications of the mitotic apparatus and the periodic variations in intracellular concentrations of calcium or of certain enzymes (cyclins, Cdc2) during the main transitions of the cell cycle. (shrink)

In the spring of 1784 the Marquis of Puységur, a great landowner and colonel in an artillery regiment, was called to the bedside of Victor, the son of his steward, who was suffering from pneumonia. Puységur was a follower of the new holistic medicine taught in an atmosphere of intense enthusiasm and scandal by Franz-Anton Mesmer, an Austrian doctor who had been living in Paris for several years. As a disciple of Mesmer, he intended to direct his ‘vital fluid’ onto (...) the young patient, by means of ‘magnetic passes’, to provoke ‘spasms’ which would lead to a calm state and an improvement in health. But things did not go as anticipated. Instead of displaying the anticipated spasms, the young Victor sank into a strange state of unconsciousness which, at first sight, resembled a deep sleep. Then he revived once more and came to life with a new personality. Freed from his inhibitions, he no longer spoke his habitual dialect, but the French of aristocrats, and he had no hesitation in berating his school teacher, whose secret thoughts he appeared to be able to read. Finally, he forecast the stages by which he would be cured and the remedies which would be suitable for him. Puységur wrote down all these strange facts and the following year he published a report which caused a sensation. Soon, throughout France, somnambulists appeared and observations about their subjects gathered. From that time onwards, the incomprehensible facts apparently evident in ‘provoked’ or ‘artificial somnambulism’ and also in ‘magnetic sleep’ - such expressions were used by Puységur and his followers for the state that he had just discovered - were to give rise to huge controversy. The Marquis of Puységur triggered the development nineteenth century of a movement of reflections and practices which have generally been referred to by the expression ‘animal magnetism’, invented by Mesmer. On the eve of the Revolution and throughout the nineteenth century this movement held a real fascination for philosophers, writers, and scholars. But there has been a tendency to overlook this episode in European culture, which has ultimately become a “lost continent” in our own period. (shrink)

The French Jesuit, Pierre Teilhard de Chardin wrote provocatively about world civilization from his dual expertise as paleontologist and Catholic priest. This paper will extract from his many writings references to civilizational process in terms of his concept of the noosphere, that is, the transhuman accumulation of knowledge. Basing himself on the notion of a geogenetic process that he described in his important publication, Le Phenomenene Humain (1955), de Chardin considered the evolution of humankind to involve not merely the change (...) of individual members of the species, but in the development of the capacity to shape the earth and its forces by the invention of technology. He foresaw the human creation of a new level of understanding (some would say this is the cyberspace of the Internet) that would be the achievement of a unifying human civilization. The impulse to contribute to and benefit from this wealth of shared knowledge constituted for the Jesuit a quasi-magnetic force that brought together disparate human experiences. Borne in part by his religious faith, de Chardin described in a second masterpiece, Le Milieu Divin (1957) this unifying force as “love”. When a new world civilization learned to harness this kind of love in common purpose, said de Chardin, “for a second time in the history of the world, man will have discovered fire”. Possibly because of his religiously tinted language and mystical orientation, Teilhard has not always been viewed a contributor to the field. This paper will offer suggestions for ways to incorporate the French Jesuit among the sources for civilizational analysis. (shrink)

Different approaches to special relativity (SR) are discussed. The first approach is an invariant approach, which we call the “true transformations (TT) relativity.” In this approach a physical quantity in the four-dimensional spacetime is mathematically represented either by a true tensor (when no basis has been introduced) or equivalently by a coordinate-based geometric quantity comprising both components and a basis (when some basis has been introduced). This invariant approach is compared with the usual covariant approach, which mainly deals with the (...) basis components of tensors in a specific, i.e., Einstein's coordinatization of the chosen inertial frame of reference. The third approach is the usual noncovariant approach to SR in which some quantities are not tensor quantities, but rather quantities from “3+1” space and time, e.g., the synchronously determined spatial length. This formulation is called the “apparent transformations (AT) relativity.” It is shown that the principal difference between these approaches arises from the difference in the concept of sameness of a physical quantity for different observers. This difference is investigated considering the spacetime length in the “TT relativity” and spatial and temporal distances in the “AT relativity.” It is also found that the usual transformations of the three-vectors (3-vectors) of the electric and magnetic fields E and B are the AT. Furthermore it is proved that the Maxwell equations with the electromagnetic field tensor Fab and the usual Maxwell equations with E and B are not equivalent, and that the Maxwell equations with E and B do not remain unchanged in form when the Lorentz transformations of the ordinary derivative operators and the AT of E and B are used. The Maxwell equations with Fab are written in terms of the 4-vectors of the electric Ea and magnetic Ba fields. The covariant Majorana electromagnetic field 4-vector Ψa is constructed by means of 4-vectors Ea and Ba and the covariant Majorana formulation of electrodynamics is presented. A Dirac like relativistic wave equation for the free photon is obtained. (shrink)

Delay discounting is a common phenomenon in daily life, which refers to the subjective value of a future reward decreasing as a function of time. Previous studies have identified several cortical regions involved in delay discounting, but the neural network constructed by the cortical regions of delay discounting is less clear. In this study, we employed resting-state functional magnetic resonance imaging (RS-fMRI) to measure the spontaneous neural activity in a large sample of healthy young adults and used the Monetary Choice (...) Questionnaire to directly measure participants’ level of delay discounting. To identify the neural network of delay discounting at rest, we used an individual difference approach to explore brain regions whose spontaneous activities were related to delay discounting across the whole brain. Then, these brain regions served as seeds to identify the neural network of delay discounting. We found that the fractional amplitude of low-frequency fluctuations (fALFF) of the left insula were positively correlated to delay discounting. More importantly, its connectivity to the anterior cingulate cortex was read out for participants’ behavioral performance in the task of delay discounting. In short, our study provides empirical evidence that insula-anterior cingulate cortex connectivity may serve as a part of the neural network for delay discounting. (shrink)

The purpose of the article is to analyze the meaning of examples in C. Hempel’s works. Hempel uses many examples referring to readings of magnetic hand, burning of white phosphorus, predictions of properties of some elements of the table of Mendeleev, to astrophysical hypotheses, terms of total solar eclipse, throwing of dice, as well as on unmarried men, on white and black swans, green mermaids, black crows and white shoes, blue roses, predictions of Jones’ recovery, the eruption of Vesuvius, the (...) assassination of Julius Caesar, and other “special cases” and “concrete facts”. The question is raised as to whether the case studies are mere illustrative material, a form of argumentation; a way of verifying Hempel’s ideas, their “demonstrable confirmation”, and in this sense a definite empirical basis for the study. The necessity of analyzing concrete examples in the context of Hempel’s theoretical research is shown, for which the examples turn out to be an occasion for investigating the logic of confirmation and the logic of explanation, for analyzing the structures of explanans and explanandum, for understanding the differences in inductive and deductive logical constructions, and for analyzing “quasi-induction”. The paper discusses Hempel’s famous example, the crow paradox, which is named in his honor and is a kind of logical provocation. (shrink)

We examine metonymy at psycho- and neurolinguistic levels, seeking to adjudicate between two possible processing implementations. We compare highly conventionalized systematic metonymy to lesser-conventionalized circumstantial metonymy. Whereas these two metonymy types differ in terms of contextual demands, they each reveal a similar dependency between the named and intended conceptual entities. We reason that if each metonymy yields a distinct processing time course and substantially non-overlapping preferential localization pattern, it would not only support a two-mechanism view but would suggest that conventionalization (...) acts as a linguistic categorizer. By contrast, a similar behavior in time course and localization would support a one-mechanism view and the inference that conventionalization acts instead as a modulator of contextual felicitousness, and that differences in interpretation introduced by conventionalization are of degree, not of kind. Results from three paradigms: self-paced reading, event-related potentials, and functional magnetic resonance imaging, reveal the following: no main effect by condition for either metonymy type immediately after the metonymy trigger, and a main effect for only the Circumstantial metonymy one word post-trigger ; a N400 effect across metonymy types and a late positivity for Circumstantial metonymy ; and a highly overlapping activation connecting the left ventrolateral prefrontal cortex and the left dorsolateral prefrontal cortex. Altogether, the pattern observed does not reach the threshold required to justify a two-mechanism system. Instead, the pattern is more naturally understood as resulting from the implementation of a generalized referential dependency mechanism, modulated by degree of context dependence/conventionalization, thus supporting architectures of language whereby “lexical” and “pragmatic” meaning relations are encoded along a cline of contextual underspecification. (shrink)

In this paper the Lorentz transformations (LT) and the standard transformations (ST) of the usual Maxwell equations (ME) with the three-dimensional (3D) vectors of the electric and magnetic fields, E and B, respectively, are examined using both the geometric algebra and tensor formalisms. Different 4D algebraic objects are used to represent the usual observer dependent and the new observer independent electric and magnetic fields. It is found that the ST of the ME differ from their LT and consequently that the (...) ME with the 3D E and B are not covariant upon the LT but upon the ST. The obtained results do not depend on the character of the 4D algebraic objects used to represent the electric and magnetic fields. The Lorentz invariant field equations are presented with 1-vectors E and B, bivectors EHv and BHv and the abstract tensors, the 4-vectors Ea and Ba. All these quantities are defined without reference frames, i.e., as absolute quantities. When some basis has been introduced, they are represented as coordinate-based geometric quantities comprising both components and a basis. It is explicitly shown that this geometric approach agrees with experiments, e.g., the Faraday disk, in all relatively moving inertial frames of reference, which is not the case with the usual approach with the 3D bf E and B and their ST. (shrink)

Neuroimaging is critical in the diagnosis and treatment of brain cancers; however, the first detection of tumors is a challenge. Detection techniques like image segmentation are heavily reliant on the segmented image’s resolution. Magnetic resonance imaging tumor segmentation has emerged as a new study area in the medical imaging field. This spongy and delicate mass of tissue is the brain. Stable conditions allow for patterns to enter and interact with each other. To put it simply, a tumor is a mass (...) of tissue that has grown unchecked by the natural mechanisms that keep it under control. When cells divide uncontrollably, they create a cancerous tumor. Brain tumors can be detected and segmented using a variety of methods. A new method for detecting brain tumors using MRI images is presented in this research. An innovative Woelfel filter is used for enhancement, and morphological segmentation approaches combined with anisotropic diffusion are used for segmentation. Segmentation of brain tumors can be accomplished using thresholding and morphological techniques, which are both effective. The tumor will be located and identified using morphological image processing. Image denoising refers to the process of removing artefacts such as noise and aliasing from digital images. Here MATLAB programming language is utilised as it incorporates all the toolboxes required for the application involved in the work. (shrink)

Aharonov and Bohm showed that, far from being merely a mathematical tool, the vector potential \ can have a microphysical effect even when irrotational, in which case the magnetic field is null. Still, at first sight there is something weird about this situation. Do we have to admit a new force? I argue that there is no paradox in the potentials-formulation of electrodynamics, for it shows that, while “\” represents a vanishing magnetic field, it alters the motion of charged matter (...) dragged by the electric field. (shrink)

Mental state reasoning or theory-of-mind has been the subject of a rich body of imaging research. Although such investigations routinely tap a common set of regions, the precise function of each area remains a contentious matter. With the help of functional magnetic resonance imaging (fMRI), we sought to determine which areas are involved when processing mental state or intentional metarepresentations by focusing on the relational aspect of such representations. Using non-intentional relational representations such as spatial relations between persons and between (...) objects as a contrast, the results ascertained the involvement of the precuneus, the temporal poles, and the medial prefrontal cortex in the processing of intentional representations. In contrast, the anterior superior temporal sulcus and the left temporo-parietal junction were implicated when processing representations that refer to the presence of persons in relational contexts in general. The right temporo-parietal junction, however, was specifically activated for persons entering spatial relations. The level of representational complexity, a previously unexplored factor, was also found to modulate the neural response in some brain regions, such as the medial prefrontal cortex and the right temporo-parietal junction. These findings highlight the need to take into account the critical roles played by an extensive network of neural regions during mental state reasoning. (shrink)

. Once constituted, scientific facts have a way of roaming about on their own in the world, much divorced from the circumstances of their original constitution. An important part of Latour and Woolgar's discussion in Laboratory Life was to draw attention to how facts are used once they are at the final stage of their constitution. What I propose to do here is to go one step further, and to follow a single fact around in the wild—to tag it, as (...) it were, much as a biologist might tag an animal with a radio collar—and then look to see where it turns up. The fact I have chosen is especially taggable, simply because it happens to be fantastic: I refer to the fact that magnets will lose their power of attraction if they are rubbed with garlic. This fact is also useful because it shows up in authors spanning fifteen centuries, from Plutarch through Rabelais and beyond, and over this time it shows some interesting behaviors. Of course, in the end, the garlic-magnet antipathy was disproved, and so changed its epistemological status, moving from one extreme to the other: from the obviously true to the obviously ridiculous. What struck Rabe-. (shrink)

The dominant model for interpreting brain imaging experiments assumes that the brain is organized to support mental processes that control behavior. However functional neuroimaging experiments, particularly of cognitive tasks, have not shown a high level of reproducibility and localization. This lack of clear functional segregation has been blamed on limitations in imaging technology and non linearity and regional overlap in how the brain implements these processes. However the validity of the underlying cognitive models used to describe the brain have rarely (...) been questioned or directly tested against imaging results. We propose an alternative model of brain function which correlates observed human behavior directly with measured brain activity without assumptions about intervening cognitive processes, that we term the Non-Cognitive Behavioral Model (NBM). Our model derives from Behavioral Psychology but is extended to include brain activations in addition to behavior as an observable. A further extension is the role of neuroplasticity as opposed to innate cognitive processes in the development of the brains support of cognitive behavior. Applications of NBM to neuroimaging studies are described and contrasted with the standard methodology which we refer to as the Standard Cognitive Model (SCM). In one application, the NBM correctly predicted the global, total energy consumption as the brain parameter that best correlates with a person being in the state of consciousness, a correlation missed by studies using the SCM due to its assumption that global activity does not support cognitive processes. Neuroplasticity is shown to provide a natural explanation of findings that object recognition activating the fusiform facial area comes from expertise through raining as opposed to the SCM explanation of an innate cognitive process specialized for face recognition. The conclusions are generalized to explain the poor reproducibility of cognitive processes reported in functional neuroimaging and to suggest how such studies can be used to better explain how the brain supports behavior. (shrink)