To explore how molecules became signs I will ask: “What sort of process is necessary and sufficient to treat a molecule as a sign?” This requires focusing on the interpreting system and its interpretive competence. To avoid assuming any properties that need to be explained I develop what I consider to be a simplest possible molecular model system which only assumes known physics and chemistry but nevertheless exemplifies the interpretive properties of interest. Three progressively more complex variants of this model (...) of interpretive competence are developed that roughly parallel an icon-index-symbol hierarchic scaffolding logic. The implication of this analysis is a reversal of the current dogma of molecular and evolutionary biology which treats molecules like DNA and RNA as the original sources of biological information. Instead I argue that the structural characteristics of these molecules have provided semiotic affordances that the interpretive dynamics of viruses and cells have taken advantage of. These molecules are not the source of biological information but are instead semiotic artifacts onto which dynamical functional constraints have been progressively offloaded during the course of evolution. (shrink)

Theses on the semiotic study of life as presented here provide a collectively formulated set of statements on what biology needs to be focused on in order to describe life as a process based on semiosis, or sign action. An aim of the biosemiotic approach is to explain how life evolves through all varieties of forms of communication and signification (including cellular adaptive behavior, animal communication, and human intellect) and to provide tools for grounding sign theories. We introduce the concept (...) of semiotic threshold zone and analyze the concepts of semiosis, function, umwelt, and the like as the basic concepts for theoretical biology. (shrink)

In the last decade, reading research has seen a paradigmatic shift. A new wave of computational models of orthographic processing that offer various forms of noisy position or context-sensitive coding have revolutionized the field of visual word recognition. The influx of such models stems mainly from consistent findings, coming mostly from European languages, regarding an apparent insensitivity of skilled readers to letter order. Underlying the current revolution is the theoretical assumption that the insensitivity of readers to letter order reflects the (...) special way in which the human brain encodes the position of letters in printed words. The present article discusses the theoretical shortcomings and misconceptions of this approach to visual word recognition. A systematic review of data obtained from a variety of languages demonstrates that letter-order insensitivity is neither a general property of the cognitive system nor a property of the brain in encoding letters. Rather, it is a variant and idiosyncratic characteristic of some languages, mostly European, reflecting a strategy of optimizing encoding resources, given the specific structure of words. Since the main goal of reading research is to develop theories that describe the fundamental and invariant phenomena of reading across orthographies, an alternative approach to model visual word recognition is offered. The dimensions of a possible universal model of reading, which outlines the common cognitive operations involved in orthographic processing in all writing systems, are discussed. (shrink)

A simple molecular system is described consisting of the reciprocal linkage between an autocatalytic cycle and a self-assembling encapsulation process where the molecular constituents for the capsule are products of the autocatalysis. In a molecular environment sufficiently rich in the substrates, capsule growth will also occur with high predictability. Growth to closure will be most probable in the vicinity of the most prolific autocatalysis and will thus tend to spontaneously enclose supportive catalysts within the capsule interior. If subsequently disrupted in (...) the presence of new substrates, the released components will initiate production of additional catalytic and capsule components that will spontaneously re-assemble into one or more autocell replicas, thereby reconstituting and sometimes reproducing the original. In a diverse molecular environment, cycles of disruption and enclosure will cause auto-cells to incidentally encapsulate other molecules as well as reactive substrates. To the extent that any captured molecule can be incorporated into the autocatalytic process by virtue of structural degeneracy of the catalytic binding sites, the altered autocell will incorporate the new type of component into subsequent replications. Such altered autocells will be progenitors of “lineages” with variant characteristics that will differentially propagate with respect to the availability of commonly required substrates. Autocells are susceptible to a limited form of evolution, capable of leading to more efficient, more environmentally fitted, and more complex forms. This provides a simple demonstration of the plausibility of open-ended reproduction and evolvability without self-replicating template molecules or maintenance of persistent nonequilibrium chemistry. This model identifies an intermediate domain between prebiotic and biotic systems and bridges the gap from nonequilibrium thermodynamics to life. (shrink)

The scientific, ethical, and policy issues raised by research involving the engraftment of human neural stem cells into the brains of nonhuman primates are explored by an interdisciplinary working group in this Policy Forum. The authors consider the possibility that this research might alter the cognitive capacities of recipient great apes and monkeys, with potential significance for their moral status.

Social animals are provisioned with pro-social orientations that transcend self-interest. Morality, as used here, describes human versions of such orientations. We explore the evolutionary antecedents of morality in the context of emergentism, giving considerable attention to the biological traits that undergird emergent human forms of mind. We suggest that our moral frames of mind emerge from our primate pro-social capacities, transfigured and valenced by our symbolic languages, cultures, and religions.

In the target article “How molecules became signs” I offer a molecular “thought experiment” that provides a paradigm for resolving the major incompatibilities between biosemiotic and natural science accounts of living processes. To resolve these apparent incompatibilities I outline a plausible empirically testable model system that exemplifies the emergence of chemical processes exhibiting semiotic causal properties from basic nonliving chemical processes. This model system is described as an autogenic virus because of its virus-like form, but its nonparasitic self-repair and reproductive (...) dynamics. The 16 commentaries responding to this proposal recognize its material plausibility but are divided on its value in resolving this basic biosemiotic challenge. In response, I have addressed some of the most serious criticisms raised and have attempted to diagnose the major sources of incompatible assumptions that distinguish the autogenic paradigm from other major paradigms. In particular, I focus on four main issues: the significance of the shift from a cellular to a viral perspective, the relevance of intrinsic versus extrinsic initiation and channeling of interpretive work, the insufficiency of molecular replication as a basis for grounding biological semiosis, and a (universal?) three step scaffolding logic that enables referential displacement of sign vehicle properties without loss of referential continuity (as exemplified by DNA-protein relations). Although I can’t conclude that this is the only way that biosemiotic properties can emerge from physical-chemical relations that otherwise lack these properties, I contend that this approach offers a biologically plausible demonstration that it is possible. (shrink)

To naturalize the concept of teleological causality in biology it is not enough to avoid assuming backward causation or positing the existence of an inscrutable te- leological essence like the élan vital. We must also specify how the causality of or- ganisms is distinct from the causality of designed artifacts like thermostats or asym- metrically oriented processes like the ubiquitous increase of entropy. Historically, the concept of teleological causality in biology has been based on an analogy to the familiar experience (...) of purposeful action. This is experienced by us as a disposition to achieve a general type of end that is represented in advance, and which regulates the selection of efficient means to achieve it. Inspired by this analogy, to bridge the gap between biology and human agency we describe a simple molecular pro- cess called autogenesis that shows how two linked complementary self-organizing processes can give rise to higher-order relations that resemble purposeful disposi- tions, though expressed in terms of constraints on molecular processes. Because the autogenic model is described in sufficient detail to be empirically realizable, it provides a proof of principle demonstrating a simple form of teleological causality. (shrink)

Kalevi Kull and colleagues recently proposed eight theses as a conceptual basis for the field of biosemiotics. We use these theses as a framework for discussing important current areas of debate in biosemiotics with particular reference to the articles collected in this issue of Zygon.

Elite athletes, coaches and high-performance staff are exposed to a range of stressors that have been shown to increase their susceptibility to experiencing mental ill-health. Despite this, athletes may be less inclined than the general population to seek support for their mental health due to stigma, perceptions of limited psychological safety within sport to disclose mental health difficulties and/or fears of help-seeking signifying weakness in the context of high performance sport. Guidance on the best ways to promote mental health within (...) sporting environments is increasing, though current frameworks and position statements require greater focus on a whole of system approach, in which the needs of athlete, coaches and high-performance staff are considered within the context of the broader ecological system in which they operate and perform. This paper synthesizes existing research, reviewed for translatability by mental health professionals working in elite sport, to provide an evidence-informed framework with real world utility to promote mentally healthy environments for all stakeholders in elite sporting organizations, from athletes through to administrators. Recommendations are provided to positively impact the mental wellbeing of athletes and support staff, which may in turn influence athletic performance. This framework is intended to provide sporting organizations with evidence-informed or best practice principles on which they can develop or progress their policies to support mental health promotion and prevent the onset of mental health difficulties. It is intended that the framework can be adapted or tailored by elite sporting organizations based upon their unique cultural, contextual and resourcing circumstances. (shrink)

Poverty of the Stimulus Arguments have convinced many linguists and philosophers of language that a domain specific language acquisition device (LAD) is necessary to account for language learning. Here we review empirical evidence that casts doubt on the necessity of this domain specific device. We suggest that more attention needs to be paid to the early stages of language acquisition. Many seemingly innate language-related abilities have to be learned over the course of several months. Further, the language input contains rich (...) stochastic information that can be accessed by domain-general learning mechanisms. Computer simulation has shown how mechanisms that are not domain specific can exploit the information contained in language. We conclude that (i) Poverty of the Stimulus Arguments need to be conceptually clarified and (ii) more empirical research needs to be carried out before we can rule out that data driven general purpose mechanisms can account for language learning. (shrink)

Contemporary textbooks often define evolution in terms of the replication, mutation, and selective retention of DNA sequences, ignoring the contribution of the physical processes involved. In the closing line of The Origin of Species, however, Darwin recognized that natural selection depends on prior more basic living functions, which he merely described as life’s “several powers.” For Darwin these involved the organism’s capacity to maintain itself and to reproduce offspring that preserve its critical functional organization. In modern terms we have come (...) to recognize that this involves the continual generation of complex organic molecules in complex configurations accomplished with the aid of persistent far-from-equilibrium chemical self-organizing and self-assembling processes. But reliable persistence and replication of these processes also requires constantly available constraints and boundary conditions. Organism autonomy further requires that these constraints and co-dependent dynamics are reciprocally produced, each by the other. In this paper I argue that the different constraint-amplifying dynamics of two or more self-organizing processes can be coupled so that they reciprocally generate each other’s critical supportive boundary conditions. This coupling is a higher-order constraint that effectively constitutes a sign vehicle “interpreted” by the synergistic dynamics of these co-dependent self-organizing process so that they reconstitute this same semiotic-dynamic relationship and its self-reconstituting potential in new substrates. This dynamical co-dependence constitutes Darwin’s “several powers” and is the basis of the biosemiosis that enables evolution. (shrink)

We agree with Brette's assessment that the coding metaphor has become more problematic than helpful for theories of brain and cognitive functioning. In an effort to aid in constructing an alternative, we argue that joining the insights from the dynamical systems approach with the semiotic framework of C. S. Peirce can provide a fruitful perspective.

In this review, we describe some of the central philosophical issues facing origins-of-life research and provide a targeted history of the developments that have led to the multidisciplinary field of origins-of-life studies. We outline these issues and developments to guide researchers and students from all fields. With respect to philosophy, we provide brief summaries of debates with respect to (1) definitions (or theories) of life, what life is and how research should be conducted in the absence of an accepted theory (...) of life, (2) the distinctions between synthetic, historical, and universal projects in origins-of-life studies, issues with strategies for inferring the origins of life, such as (3) the nature of the first living entities (the “bottom up” approach) and (4) how to infer the nature of the last universal common ancestor (the “top down” approach), and (5) the status of origins of life as a science. Each of these debates influences the others. Although there are clusters of researchers that agree on some answers to these issues, each of these debates is still open. With respect to history, we outline several independent paths that have led to some of the approaches now prevalent in origins-of-life studies. These include one path from early views of life through the scientific revolutions brought about by Linnaeus (von Linn.), Wöhler, Miller, and others. In this approach, new theories, tools, and evidence guide new thoughts about the nature of life and its origin.We also describe another family of paths motivated by a” circularity” approach to life, which is guided by such thinkers as Maturana & Varela, Gánti, Rosen, and others. These views echo ideas developed by Kant and Aristotle, though they do so using modern science in ways that produce exciting avenues of investigation. By exploring the history of these ideas, we can see how many of the issues that currently interest us have been guided by the contexts in which the ideas were developed. The disciplinary backgrounds of each of these scholars has influenced the questions they sought to answer, the experiments they envisioned, and the kinds of data they collected. We conclude by encouraging scientists and scholars in the humanities and social sciences to explore ways in which they can interact to provide a deeper understanding of the conceptual assumptions, structure, and history of origins-of-life research. This may be useful to help frame future research agendas and bring awareness to the multifaceted issues facing this challenging scientific question. (shrink)

The technical concept of information developed after Shannon [22] has fueled advances in many fields, but its quantitative precision and its breadth of application have come at a cost. Its formal abstraction from issues of reference and significance has reduced its usefulness in fields such as biology, cognitive neuroscience and the social sciences where such issues are most relevant. I argue that explaining these nonintrinsic properties requires focusing on the physical properties of the information medium with respect to those of (...) its physical context—and specifically the relationship between the thermodynamic and information entropies of each. Reference is shown to be a function of the thermodynamic openness of the information medium. Interactions between an informing medium and its physical context that drive the medium to a less probable state create intrinsic constraints that indirectly reflect the form of this extrinsic influence. This susceptibility of an informing medium to the effects of physical work is also relevant for assessing the significance or usefulness of information. Significance can be measured in terms of work “saved” due to access to information about certain contextual factors relevant to achieving a preferred target condition. (shrink)

Language and information processes are critical issues in scientific controversies regarding the qualities that epitomize humanness. Whereas some theorists claim human mental uniqueness with regard to language, others point to successes in teaching language skills to other animals. However, although these animals may learn names for things, they show little ability to utilize a complex framework of symbolic reference. In such a framework, words or other symbols refer not only to objects and concepts but also to sequential and hierarchical relationships (...) with other symbols. This process is essential to human mental operations, including language, mathematics, and music. In humans, these operations may have coevolved with the prefrontal area of the cerebral cortex, which is proportionately much larger in humans than in other animals and more intricately linked with other areas of the brain. Analysis of the structure and function of the prefrontal area suggests that it is centrally involved in the operation of higher‐order associative relationships involving the subordination of one set of associations to another. This alternate learning strategy apparently appeared at the cost of certain sensory, motor, or limbic abilities. The payoff was symbolic thinking. Humans thus are unique among species, not just for their highly developed language ability but for their odd style of thinking and learning. (shrink)

To understand how we have become what we are requires, following Foucault, not a theory but an `analytics' which examines how technologies of power and knowledge have, since antiquity, intertwined and developed in concrete and historical frameworks. Distilling from Foucault's oeuvre as a whole a rough periodization of western political rationalities, this article shows how the processes whereby some people discipline or govern others are frequently closely connected to procedures of identity-constitution and knowledge-production. Platonic, Stoic and Christian pursuits of self-mastery (...) and self-knowledge, often via the intervention of an external master, were initially confined to an elite, but thereafter were amplified and generalized to encompass entire populations in conjunction with the rise of the modern state. Via techniques of confession and ascetic conduct, faith and empiricism, and selfreflection and everyday reality, western political rationalities, in the form of combined totalization and individualization technologies whereby some (struggle to) discipline others even as all (are exhorted to) discipline themselves, have come to dominate the globe. (shrink)

The opening sentence to Michael Hardt's and Antonio Negri's Empire1 is pregnant with promise and peril. Signifying a process deemed to be under way, it hearkens back to and beyond that famous Manifesto of 1848, even while looking forward to a time when what is now only imminent will have become reality. In part summoned into existence to fulfill the ancient prophecies of declining Rome and rising Christianity, Empire is said to be 'realizing' or 'manifesting' itself in time honoured 19th-century, (...) especially Marxist, fashion; but whereas the specter invoked by the Communist Manifesto haunted only a continent, the immaterial spirit of Empire, dripping crisis like ectoplasm, stalks the entire world. (shrink)

Reading development is integral to a universal model of reading. Developmental research can tell us which factors drive reading acquisition and which are the product of reading. Like adult research, developmental research needs to be contextualised within the language and writing system and it needs to include key cross-linguistic evaluations. This will create a universal model of reading development.

This article develops a Foucauldian account of the rise of the modern school, on the basis of a thorough examination of all references to education in Foucault's work. It analyses the seventeenth-century origins of mass schooling and traces its development up to the nineteenth century. It identifies several overlapping stages in this multifaceted and largely contingent development, particularly a fundamental shift from a negative to a positive conception of the school. This Foucauldian understanding of the rise of schooling as a (...) disciplinary technology suggests that an initial focus on the exclusion or confinement of disorderly groups was gradually superseded by a focus on the inclusion or “attachment” of diverse individuals and on the development of their potential. It concludes by cautioning against over-simplistic applications of Foucault's work to the field of education. (shrink)

Language is a spontaneously evolved emergent adaptation, not a formal computational system. Its structure does not derive from either innate or social instruction but rather self-organization and selection. Its quasi-universal features emerge from the interactions among semiotic constraints, neural processing limitations, and social transmission dynamics. The neurological processing of sentence structure is more analogous to embryonic differentiation than to algorithmic computation. The biological basis of this unprecedented adaptation is not located in some unique neurologieal structure nor the result of any (...) single mutation, but is vested in the synergistic interaction of numerous coevolved neurological biases and social dynamics. (shrink)

The first major advances in the understanding of the neurological bases for language abilities were the results of the study of the brains and behaviors of patients with language impairments due to focal brain damage. The two most prominent pioneers in this field are remembered because their names have become associated with distinctive aphasia (language loss) syndromes and the brain regions associated with them. In 1861 Paul Broca described the damage site in the brain of a patient who had lost (...) the ability to produce articulate speech as a result of a stroke. Broca's aphasia, as it is now commonly called, is produced by damage that involves the inferior left frontal lobe of the brain. It tends to produce both a loss of articulatory skill (sometimes but not always with paralysis) and (as discovered much later) problems with grammar and syntax, including grammatical comprehension under certain conditions. Despite speech production impairments, Broca's aphasics do not have basic word‐ and sentence‐comprehension difficulties, when comprehension is not dependent on syntactic analysis. In 1874 Carl Wernicke demonstrated that damage to the left superior temporal lobe produced a different syndrome of language impairments. Wernicke's aphasia generally spares fluent, syntactic speech but impairs the use and comprehension of content words. Wernicke's aphasics'speech includes inappropriate word substitutions, neologisms, and semantic confusions, and their comprehension is similarly disturbed. These early studies also demonstrated that these aphasic disturbances were almost exclusively associated with damage to the structures of the left cerebral hemisphere, even though anatomically corresponding structures are present on both sides of the brain. However, this is not true of all language functions. Some left‐handed individuals can suffer aphasia from right hemisphere damage, and recent studies of patients with right hemisphere damage without aphasia have demonstrated impairment of their comprehension above the sentence level (e.g., interpretation of jokes and stories) and in the production and interpretation of prosodic features of speech (rhythmic and tonal patterning that conveys emphasis and emotion). (shrink)

Il arrive qu’une complexité extrême mette le modèle de la sélection naturelle au défi d’expliquer quoi que ce soit. Depuis Darwin, l’aptitude humaine au langage est incessamment citée en exemple-type de ce cas de figure. Et ceux qui ont souligné les problèmes posés par cette faculté si spécifiquement humaine n’étaient pas tous des critiques du darwinisme. On sait l’argument avancé par Alfred Russel Wallace, co-instigateur de la théorie de la sélection naturelle, et réputé plus darwiniste que ..

Globalization presages an important new stage in the centuries-old 'civilizing process,' which Norbert Elias analyzed with such clarity and in such depth. At the root of the fundamental transformations of our world of nation-states are combined integrating and disintegrating tendencies, or centralization and individualization, which manifest themselves in a steady monopolization of the means of violence and taxation, an interventionist human rights discourse, and war as a means of democratizing and pacifying the planet. Elias' 'historical social psychological' approach offers new (...) categories of analysis with which to both explain the effects of globalization and indicate how international interdependence fosters both control and resistance, both democratization and radicalization, and both integration and disintegration. (shrink)