pars 1. Exhibens principia cum generalia politicae publicae tum simplicibus civitatum formis propria -- pars 2. Continens sapientiam publicam in temperandis rerum publicarum formis procurando iusto civium numero ... -- pars 3. Sistens sapientiam publicam in perficiendis civium voluntate eorundemque corpore et statu externo -- pars 4. Tradens prudentiam publicam, vel artem feliciter regnandi in statu civitatis pacato, cum indice quatour [sic] tomorum.

pars 1. Exhibens principia cum generalia politicae publicae tum simplicibus civitatum formis propria -- pars 2. Continens sapientiam publicam in temperandis rerum publicarum formis procurando iusto civium numero ... -- pars 3. Sistens sapientiam publicam in perficiendis civium voluntate eorundemque corpore et statu externo -- pars 4. Tradens prudentiam publicam, vel artem feliciter regnandi in statu civitatis pacato, cum indice quatour [sic] tomorum.

The double membrane of the nuclear envelope is a formidable barrier separating the nucleus and cytoplasm of eukaryotic cells. However, movement of specific macromolecules across the nuclear envelope is critical for embryonic development, cell growth and differentiation. Transfer of molecules between the nucleus and cytoplasm occurs through the aqueous channel formed by the nuclear pore complex (NPC)Abbreviations: NPC, nuclear pore complex; GlcNac, N‐acetylglucosamine; WGA, wheat germ agglutinin. Although small molecules may simply diffuse across the NPC, transport of large proteins and (...) RNA requires specific transport signals and is energy dependent. A family of pore glycoproteins modified by O‐linked N‐acetylglucosamine moieties are essential for transport through the NPC. Recent evidence suggests that the regulation of nuclear transport may also involve the inteaction of RNA and nuclear proteins with specific binding proteins that recognize these transport signals. Are these nuclear pore glycoproteins and signal binding proteins the ‘gatekeepers’ that control access to the genetic material? Recent evidence obtained from a combination of biochemical and genetic approaches suggests – perhaps. (shrink)

SUMMARYOriginally composed as a series of polemical essays to a weekly newspaper called The London Journal, appearing from November 1720 to July 1723, John Trenchard and Thomas Gordon's Cato's Letters had a lasting influence on the development and evolution of Country ideology. It was, as is well known, one of the most widely read and influential books in Revolutionary America. Because of the enduring influence it had on the dissemination of the civic humanist tradition from Britain to North America, Cato's (...) Letters has been more often than not taken out of historical context. This article revisits Cato's Letters by placing it against the background of the War of the Quadruple Alliance of 1718–20. What Trenchard and Gordon strove to do was to construct a distinctively Whig vision of Britain's maritime future that in a fundamental way rested on the Hanoverian Succession of 1714 and justified the conduct of foreign policy under George I and, more especially, the controversial alliance with France in 1716. The focal point of Cato's foreign-policy platform was Gibraltar. But were it not for the timely burst of the Mississippi Bubble in 1720, Trenchard and Gordon could not have retrained their civic humanist association of libertas and imperium with such assurance and confidence. (shrink)

In philosophical circles, Electress Sophie of Hanover (1630-1714) is known mainly as the friend, patron, and correspondent of Leibniz. While many scholars acknowledge Sophie's interest in philosophy, some also claim that Sophie dabbled in philosophy herself, but did not do so either seriously or competently. In this paper I show that such a view is incorrect, and that Sophie did make interesting philosophical contributions of her own, principally concerning the nature of mind and thought.

In this paper, the theories of the civitas maxima (universal state) in the work of Christian Wolff (1679–1754) and Michael Christoph Hanov (1695–1773) are investigated. Topics are the layers of international law, the concept and constitution of the universal state, utopian elements, the ontological status of the universal state, conversion of other states, and migration. As a critical counterpart, the idea of nation is explored in these authors as well as in the political theories of romanticism, namely in Adam Müller (...) (1779–1829) and Friedrich Daniel Ernst Schleiermacher (1768–1834). (shrink)

This article introduces three princesses: Princess Elizabeth of Bohemia (1618-1680); her sister, Princess Sophie who became the Electress of Hanover (1630-1714); and Sophie's daughter, Sophie Charlotte, who became the first Queen of Prussia (1668-1705). After summarizing their common family background, the article presents, for each in turn, her biography and a discussion of her relation to philosophy. In each case their philosophical involvement stems from their friendships with the leading philosophers of their day; Princess Elizabeth was a friend of (...) Descartes while the Electress Sophie and Sophie Charlotte were friends of Leibniz. The article concludes that anyone who has made the acquaintance of the three princesses and has studied their interaction with their philosopher-friends will always see them as part of the history of modern philosophy. (shrink)

LEIBNIZ AND THE TWO SOPHIES is a critical edition of all of the philosophically important material from the correspondence between the philosopher Gottfried Wilhelm Leibniz (1646-1716) and his two royal patronesses, Electress Sophie of Hanover (1630-1714), and her daughter, Queen Sophie Charlotte of Prussia (1668-1705). In this correspondence, Leibniz expounds in a very accessible way his views on topics such as the nature and operation of the mind, innate knowledge, the afterlife, ethics, and human nature. The correspondence also contains (...) the only known philosophical writings by Sophie and Sophie Charlotte, and thus provides a valuable insight into their views and concerns, as well as throwing light on their characters. The texts are accompanied by a substantial introductory essay which sets the context for the correspondence and analyzes its main philosophical themes. (shrink)

Problems concerning scientists’ uses of representations have received quite a bit of attention recently. The focus has been on how such representations get their contents and on just what those contents are. Less attention has been paid to what makes certain kinds of scientific representations different from one another and thus well suited to this or that epistemic end. This article considers the latter question with particular focus on the distinction between images and graphs on the one hand and descriptions (...) and related representations on the other. *Received January 2008; revised September 2009. †To contact the author, please write to: Department of Philosophy, Dartmouth College, Hanover, NH 03755; e‐mail: kulvicki@dartmouth.edu. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Women and Philosophy in Eighteenth-Century Germany ed. by Corey W. DyckJulia BorcherdingCorey W. Dyck, editor. Women and Philosophy in Eighteenth-Century Germany. Oxford: Oxford University Press, 2021. Pp. 272. Hardback, $85.00.In more ways than one, this volume constitutes an important contribution to ongoing efforts to reconfigure and enrich our existing philosophical canon and to question the narratives that have led to its current shape. To start, while there is (...) a growing amount of research dedicated to recovering the contributions of women to early modern philosophy, much of this work focuses on the seventeenth century, and geographically centers on England, France, and Italy. By turning the spotlight on eighteenth-century Germany, this volume broadens the scope of these efforts in an important way. Further, with the historiography of this period still shaped by a long-standing dismissive treatment of post-Leibnizian German philosophy and by the long shadow cast by the success of Kant's Critical philosophy, which eclipsed many of the thinkers opposed to it, challenges to its traditional narratives seem especially important. The editor's earlier collection (coedited with Falk Wunderlich) on Kant and his German contemporaries already succeeded in mounting such a challenge by showing that German philosophy throughout the eighteenth century in fact presents us with an extraordinarily rich tableau of intellectual life (Kant and His German Contemporaries. Vol. 1: Logic, Mind, Epistemology, Science and Ethics [Cambridge: Cambridge University Press, 2018]).The present volume stands as a further valuable contribution to relativizing the still dominant narrative of German philosophy as the story of a select few brilliant minds. It successfully dispenses not only with the idea that those minds were few, but also with the equally persistent one that they were exclusively male. Already in the nineteenth century, we find historians such as Karl Joël explicitly casting the new age of German philosophy inaugurated by Kant as its "masculine epoch"—an image undoubtedly furthered by its main protagonist, who cast philosophical acumen in decidedly male terms when he observed that "[a] woman who has a head full of Greek, like Madame Dacier, or one who engages in debate about the intricacies of mechanics, like the Marquise du Châtelet, might just as well have a beard; for that expresses in a more recognizable form the profundity for which she strives" (Karl Joël, Die Frauen in der Philosophie [Hamburg, 1896], 48; Immanuel Kant, Beobachtungen über das Gefühl des Schönen und Erhabenen [Königsberg, 1764], translation in Londa Schiebinger, The Mind Has No Sex? Women in the Origins of Modern Science [Cambridge, MA: Harvard University Press, 1989], 146; both cited in Eileen O'Neill, "Disappearing Ink: Early Modern Women Philosophers and Their Fate in History," in Philosophy in a Feminist [End Page 154] Voice: Critiques and Reconstructions, ed. Janet A. Kourany [Princeton, NJ: Princeton University Press, 1997], 17–62). Yet as the contributions to this volume forcefully illustrate, women in the period did—in spite of the numerous severe social, religious, and political obstacles they faced—in fact manage to gain access to its intellectual sphere, and actively shaped its philosophical landscape.While the papers collected here are of high quality throughout, they do vary in their approach. Many chapters, especially in the earlier parts of the volume, investigate female figures as philosophers in their own right, and carve out their self-standing contributions to prominent philosophical movements and debates. Focusing on Sophie of Hanover's correspondence with Leibniz, Christian Leduc's chapter begins by examining her metaphysical views and argues, against standing interpretations, that her main aim is to defend a version of the doctrine of physical influence as an account of mind-body interaction while rejecting metaphysical commitments regarding the nature of the soul in favor of a more agnostic, Lockean empiricist approach. In chapter 3, Stefanie Buchenau shows how women engaging with Wolffian Schulphilosophie began to view themselves as more than teachers and translators and started to claim the title of philosophers. Using the example of Johanna Charlotte Unzer, Buchenau convincingly argues that despite the "feminine," aesthetic garb of her thought, Unzer in fact offers a serious critique and revision of the Wolffian model of... (shrink)

The political sphere Arendt strove throughout her career to defend and restore depended upon the performative abilities of its participant speakers. But Arendt's theatricality is that of the speech act, not of the stage in a literal sense, where original utterances and originary deeds are not primarily at stake. Arendt versus Zweig replays the cultural enmity of Berlin versus Vienna, giving voice and person to a Central European cultural fissure that travels far and wide into the émigré experience and remains (...) too regularly overlooked in all of its venues by scholars of Central Europe. The distinction is especially elusive to American scholars, who often remain insufficiently sensitive both to the cultural differences between northern and southern Central Europe, and to the survival of religiously marked cultural differences. Hannah Arendt was an émigré from the northern German world and from the German language. In cultural as well as geographical terms, she was an émigré from Prussia. Born in Hanover, reared in Koenigsberg, educated in Heidelberg, she identified with Berlin and its claim to cosmopolitanism. She therefore became a cosmopolitan thinker from Berlin, a metropolis whose generosity and arrogance has resided at least since the 1870s in its self perception as the center of the world. But Arendt also did battle with her fellow Berliners, especially when they seemed to abandon their Berlin-trained worldliness. (shrink)