This chapter contains sections titled: General Assessments of Assisted Reproduction Pre‐birth Testing Conclusion References Further reading.

Much of recent philosophy of perception is oriented towards accounting for the phenomenal character of perception—what it is like to perceive—in a non-mentalistic way—that is, without appealing to mental objects or mental qualities. In opposition to such views, I claim that the phenomenal character of perception of a red round object cannot be explained by or reduced to direct awareness of the object, its redness and roundness—or representation of such objects and qualities. Qualities of perception that are not captured by (...) what one is directly aware of or by representational content are instances of what Gilbert Harman has called “mental paint” (Block, 1990; Harman, 1990). The claim of this paper is that empirical facts about attention point in the direction of mental paint. The argument starts with the claim (later modified) that when one moves one's attention around a scene while keeping one's eyes fixed, the phenomenology of perception can change in ways that do not reflect which qualities of objects one is directly aware of or the way the world is represented to be. These changes in the phenomenology of perception cannot be accounted for in terms of awareness of or representation of the focus of attention because they manifest themselves in experience as differences in apparent contrast, apparent color saturation, apparent size, apparent speed, apparent time of occurrence and other appearances. There is a way of coping with these phenomena in terms of vague contents, but vague contents cannot save direct realism or representationism because the kind of vagueness required clashes wth the phenomenology itself. (shrink)

Recent evidence from studies on DNA repair systems that are implicated in accelerated aging syndromes, have revealed a mechanism through which low levels of persistent damage might exert beneficial effects for both cancer prevention and longevity assurance. Beneficial effects of adaptive responses to low doses of insults that in higher concentrations show adverse effects are generally referred to as hormesis. There are numerous examples of hormetic effects ranging from mild stresses of irradiation to heat stress, hypergravity, pro‐oxidants, or food restriction. (...) Although the notion of hormesis is supported by many observations in various organisms, at least two major caveats have thus far prevented the application of hormesis for disease prevention in humans. First, the very nature of hormesis using toxins as a treatment regimen harbors the inherent danger of detrimental consequences. Second, the molecular mechanisms through which insults might exert beneficial effects have thus far remained elusive. Here, I discuss a mechanistic basis for hormesis and its implications for cancer prevention and healthy aging. (shrink)

This article provides a historical perspective on how both American and European psychiatrists have conceptualized and categorized sexual deviance throughout the past 150 years. During this time, quite a number of sexual preferences, desires, and behaviors have been pathologized and depathologized at will, thus revealing psychiatry's constant struggle to distinguish mental disorder--in other words, the "perversions," "sexual deviations," or "paraphilias"--from immoral, unethical, or illegal behavior. This struggle is apparent in the works of 19th- and early-20th-century psychiatrists and sexologists, but it (...) is also present in the more recent psychiatric textbooks and diagnostic manuals, such as the consecutive editions of the Diagnostic and Statistical Manual of Mental Disorders. While much of the historical literature revolves around the controversy over homosexuality, this article also reviews the recent medicohistorical and sociohistorical work on other forms of sexual deviance, including the diagnostic categories listed in the latest edition, the DSM-IV-TR: exhibitionism, voyeurism, fetishism, frotteurism, pedophilia, sexual masochism, sexual sadism, and transvestic fetishism. (shrink)

Engagement happens when academics and non-academics form partnerships to create mutual understanding, and then take action together. An example is the “value web” work associated with W. K. Kellogg Foundation’s Food Systems Higher Education–Community Partnership. Partners nationally work on local food systems development by building value webs. “Value chains,” a concept with considerable currency in the private sector, involves creating non-hierarchical relationships among otherwise disparate actors and entities to achieve collective common goals. The value web concept is extended herein by (...) separating the values of the web itself, such as the value of collaboration, from values “in” the web, such as credence values associated with a product or service. By sharing and discussing case examples of work underway around the United States, the authors make a case for employing the value webs concept to represent a strategy for local food systems development, specifically, and for higher education–community partnerships, generally. (shrink)

To the person unfamiliar with the wide variety of street art, the term “street artist” conjures a young man furtively sneaking around a decaying city block at night, spray paint in hand, defacing concrete structures, ears pricked for police sirens. The possibility of the ethical criticism of street art on such a conception seems hardly worth the time. This has to be an easy question. Street art is vandalism; vandalism is causing the intentional damage or destruction of someone else’s (...) property; causing destruction or damage is wrong. The only remaining question is which of two coarse-grained models of ethical criticism we choose. The ethicist model holds that a work of art that exhibits ethically bad properties is a work that is thereby aesthetically flawed. That is, the work is flawed as a work of art just because of its ethical flaws. Bad ethics make art worse than it otherwise would have been, although it may be aesthetically successful otherwise. The autonomist model, by contrast, holds that the ethical properties of a work of art have no bearing at all on its aesthetic success. One might suppose, therefore, that on either model, a criticism of street art would be relatively easy to undertake. In defacing public property, some street art exhibits and endorses ethically bad attitudes. On the ethicist model, such a work is thereby pro tanto aesthetically flawed because in the process of creating such works, they violate ethical norms concerning the use of public spaces; on the autonomous model, any ethical criticism of the aesthetics of street art would need to be set aside entirely in favor of criticism that focused purely on the aesthetic properties of street art. I will argue in this paper that neither the ethicist nor the autonomist model adequately captures the moral landscape of street art. Street art may indeed be criticized productively on aesthetic grounds for the destruction it does to public spaces, but the existing models of ethical criticism overlook the complex ethical landscape of street art that results from its use of public spaces. In the interplay of various forms of street art we can see the emergence of an ethical criticism of art that is accomplished by the material properties of related artwork, and consists in the creation of a dialogue over the proper use of contested public spaces. (shrink)

Inconsistent representations of the world have in fact played and should play a role in scientific inquiry. However, it would seem that logical analysis of such representations is blocked by the explosive nature of deductive inference from inconsistent premisses. "Paraconsistent logics" have been suggested as the proper way to remove this impediment and to make explication of the logic of inconsistent scientific theories possible. I argue that installing paraconsistent logic as the underlying logic for scientific inquiry is neither a (...) necessary nor a sufficient condition for giving a philosophical alternative, I suggest that identification of heuristic strategies, based on the network of confirming evidence for inconsistent proposals for reasoning from such proposals to their consistent replacements is the proper way to explicate their function in science. (shrink)

Butte, Montana, lies at the headwaters of the nation's largest Superfund site. Donald MacMillan's book is a morality tale about this environmental travesty—a story of damaged health and environment, futile efforts by citizens and government to halt that damage, and demoralization resulting from those failed efforts.MacMillan's story covers the period from the 1880s to the 1930s. In the first phase, he describes the struggle between the young city of Butte and negligent smelter owners. In the second, the smelter owners (...) shifted the problem to a nearby town and surrounding farmers. In the third, the federal government attempted to enforce conservation policy.When miners first settled Butte in the 1860s, they found a lush valley high amid the peaks of the Continental Divide. By 1890 Butte was a major source of copper for a growing nation. Ore was roasted in open heaps a city block long. Sulfur and arsenic fumes killed vegetation for miles around. When winter inversions trapped smoke, residents suffered nosebleeds and vomited in the streets. Up to eighty people a month died in this town of just 40,000.The city sent abatement notices. Mine owners ignored them, arguing, “No smoke, no wages for workingmen.” Though open heap roasting ended because it was inefficient, new roasting furnaces did little to ease the problem. The growth of the Anaconda Copper Mining Company did end the problem—at least for Butte residents. By 1906 nearly all of Butte's ore was shipped twenty‐six miles down the valley to ACM's Anaconda smelter. Each day it belched thirty tons of arsenic and 2,500 tons of sulfur into the air. Whole herds of horses, cattle, and sheep lay wasted in the fields. ACM paid $330,000 for damages within five miles of the Washoe but refused compensation to more distant farmers.Afflicted farmers filed a lawsuit, offering to settle for a $1,175,000 buyout of their 60,525 acres. ACM declared their land not worth $500,000 and then spent nearly $1 million to prove it. Farmers lost when the judge—who socialized with ACM executives—found against the farmers in 1909. ACM had utilized “best known methods” and therefore should not be liable for any damages.Smoke poisoned national forest lands as well as farmers' fields. Trees within twenty‐five miles of Anaconda were dead or damaged. President Theodore Roosevelt and Chief Forester Gifford Pinchot initiated an investigation through the U.S. attorney general's office that eventually sought $4 million in damages from ACM. The company stalled, hoping for a more tolerant administration following the elections of 1908. In 1911 President William Howard Taft, trusting industry to do the right thing, created the “Anaconda smoke commission”—a group of industry and government advisors—to oversee ACM's implementation of pollution controls. In 1916 ACM's smelter still emitted sixty‐two tons of arsenic and 1,700 tons of sulfur each day.In 1924 ACM finally took effective steps to remove most of the arsenic from its emissions. Because of high demand for arsenic insecticides to fight boll weevils, ACM made considerable profit on arsenic recovery. Problems with farmers ended when the farmers, financially bankrupt from their lawsuit, sold “smoke rights” or easements to ACM. Problems with the federal government ended after 1928 when President Herbert Hoover, who promoted government‐industrial partnership, approved the swap of healthy ACM timberlands for damaged national forest.As a resident of Butte, it is hard for me to keep in mind that this is a historical account. Although ACM's smelting operations ended in 1974, the legacy of cultural and environmental damage lingers on. The morning newspaper reported forty‐six homes in Butte contaminated with lead and arsenic: “The federal Agency for Toxic Substances and Disease Registry is conducting an investigation, and encourages all children to be tested.”. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 33.4 (2000) 303-318 [Access article in PDF] The Threshold of the Self Bradford Vivian The subject has a history. Classical Greek sculpture expressed a fascination with the formal beauty of one's self. Ever gazing outward or upward, the marble figures symbolized the Greek preoccupation with a boldness of being, a constant focus on the ideals of the body and mind, which, through their pursuit, might allow (...) one a foretaste of heaven. Centuries later, as the pagan symbols of the ancient world were replaced with those of the growing Byzantine Empire, blocks of the same marble were fashioned into very different expressions. The ideals of form made manifest in the smooth, taught lines and surfaces of classical Greek sculpture were supplanted by Byzantine art's attention to the less perfect details of the individual: distinctive and common faces, beards, clothing, and less glorified bodies. The gazes of the Byzantine statues were cast down, contemplative, reflecting Byzantium's early Christian emphasis upon the modesty of human existence, the pious appraisal of one's time on Earth. Each of these sculptural styles is a material way of thinking and expressing one's being in the world. In this context, each is also symptomatic of the conditions in which such being was possible.The subject must not be conceived as a transcendent entity. Quite to the contrary, there is a historicity to our being and its expression, to our subjectivity and its elaboration. Within a more sweeping perspective, our epochal narratives of the subject--as well as the modes of thought and speech by which we make sense of ourselves--change with each passing age.At the forefront of the current era is a manifold effort to rethink and elaborate anew the concept of the subject. Feminist scholars have initiated political critique and transformation by arguing that the very notion of a subject in Western discourse has functioned as a trope of masculine privilege cloaked in the language of equality and secular humanism. 1 Postmodernists, of course, define contemporary subjectivity as de-centered and fragmented by nature (e.g., Baudrillard 1994; Latour 1993; Lyotard 1984). And [End Page 303] a variety of interdisciplinary studies illuminate the role of modern science and technology in not only sustaining our being, but actually constituting the human; in short, our daily interdependence and union with artificial body parts, synthetic products, life-support machines, test-tube reproduction, computers, and more, characterizes the arrival of what has been called "the posthuman." 2 Like ancient marble from a quarry, however, all of these materials are sculpted in historically specific ways to simultaneously think and express our subjectivity.What role might rhetoric play in this re-imagining of subjectivity? Modern Western thought has defined the subject according to content--that is, by the nature of the essence or being the subject is said to possess. Drawn around this content, the subject comes to appear enclosed, perhaps autonomous, and identical to itself. In this essay, however, I argue that the self may be conceived as a form--a rhetorical form--that exists only in its continual aesthetic creation, in its indefinite becoming. The self is, by this account, isomorphic with the threshold out of which it is composed. Such a formulation makes the self open to difference, to continual movement and transformation, instead of identical to itself.I aim in this essay to explore the abstract rhetorical forms and functions out of which the self is composed. The distinction here amounts to no longer asking, "What is a subject?" but, "What conditions and forces enable the ongoing production of the self?" Commensurate with such a proposal, it will be essential to ask how this movement--this continual becoming--of the self is brought about. The answer to this question ultimately will amplify the role of rhetoric in, not simply expressing, but actually producing conditions of being. In what follows, I begin by reviewing the very general aspects of subjectivity that I wish to call into question. Thereafter, I explore how the subject might be conceived differently. Finally, I discuss the manner in which rhetoric may... (shrink)

Wind damage to forests can be divided into (1) the direct damage done to the forest and(2) indirect effects. Indirect effects may be of different kinds and may affect the environ- ment as well as society. For example, falling trees can lead to power and telecommunica- tion failures or blocking of roads. The salvage harvest of fallen trees is another example and one that involves extremely dangerous work. In this overview we provide examples of different entities, services, and activities that (...) may be affected by wind damage to for- ests. We illustrate how valuation of the damage depends on the perspective applied and how the affected entities, services, and activities may represent different types of values. Finally we suggest means for how to actively manage the risk in an ethically sustainable way. Many of our examples will be drawn from the experiences of the wind damage Gudrun in southern Sweden on 8–9 January 2005. The direct as well as indirect effects, which are described, are by no means unique to the Gudrun wind damage event and similar or even worse effects have been described after the wind damage events Martin and Lothar in 1999, and Klaus in 2009. (shrink)

As historian Henning Schmidgen notes, the scientific study of the nervous system would have been “unthinkable” without the industrialization of communication in the 1830s. Historians have investigated extensively the way nerve physiologists have borrowed concepts and tools from the field of communications, particularly regarding the nineteenth-century work of figures like Helmholtz and in the American Cold War Era. The following focuses specifically on the interwar research of the Cambridge physiologist Edgar Douglas Adrian, and on the technology that led to his (...) Nobel-Prize-winning research, the thermionic vacuum tube. Many countries used the vacuum tube during the war for the purpose of amplifying and intercepting coded messages. These events provided a context for Adrian's evolving understanding of the nerve fiber in the 1920s. In particular, they provide the background for Adrian's transition around 1926 to describing the nerve impulse in terms of “information,” “messages,” “signals,” or even “codes,” and for translating the basic principles of the nerve, such as the all-or-none principle and adaptation, into such an “informational” context. The following also places Adrian's research in the broader context of the changing relationship between science and technology, and between physics and physiology, in the first few decades of the twentieth century. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Stumbling Block its IndexBrian Catling (bio)The Stumbling Block is a graphic font. This black plinth was once a brush or similar terminal that was the lips of an intense electrical arc. Industries proud and violent need spoke through it to turn the wheel or smelt and cast the constructed challenge. Now abandoned it finds benediction in seclusion. It has softened its mouth to hold water, so that small (...) animals and disjointed humans may drink or sign themselves in their passage. [End Page 218]The Stumbling Block has been used like an entrance step to sharpen knives on. Its fossil bristle of bright stone forcing the heavy blades down to a hiss along one edge. These are knives of gleaming hubris, long intentions honed for malice. They are magnetized and have been placed to construct a lectern. Each blade holding the next to form the platform. It may hold this index at its centre, hovering, placed outside in the aorta of streets. The removal of any of the blades from the assembled cluster will spill their fish bodies to the ground. The paper will drink any of the stains of their usage. [End Page 219]The Stumbling Block is an ark of extinction. A bouillon hive of the murdered past, frozen dry to a mass. Something has warmed its corner, the oxoed grit bleeds a vein of contagion, virulent in its passion to embrace and swim in human tides. [End Page 220]The Stumbling Block is unfound to the stained and unclear eye. But its nest, its negative hollow can be discovered in the mounds of waste and detritus that choke the streets. Its possible wedge, sphere or beam form is there; a vacant socket, easily trampled, destroyed or cleared away. It is watching. Its obstinate grace squinting across the demonstrations of power. It is the light in the eye of the needle grown solid with anger, a fat sugar that clogs the passage to any kind of paradise. [End Page 221]The Stumbling Block is a bell that sounds a deeper voice than the throats of men. Their image and cry shrinks the world.The communication of global gossip becomes a barbed wind of trivial penning; television enclosures of wired indifference, the reduction of memory removes the open field and causes blurred shivers to be understood as the same thing. The bell hums as acceleration eradicates silence, the foundation for stillness is removed. The speed of language clones its own restless manic hunger. The portable telephone, miniature televisions, satellites and their collection dishes are the cutlery for this gluttony.The inedible thinness they devour is obvious. To feed this addiction soapy fictions are boiled from the skin and bone of poverty. Tribes, villages, jungles and the very air itself can be wasted or burnt to secure a dry armpit in puppeted dramas of nightmare lives. Condensation is sweating inside the bell; a human modes sound that is unwelcome. It drips from the rim in whispers and pools beneath its limited protection. [End Page 222]The Stumbling Block is a shape shifter, a spirit bench that dwells in the cuffs of the expanding city. Over its warn layers of woven scars many forms have been stretched, clamped and tasted, licked and cut; reshaped. Anointed by abstraction, they are put back on the blinking streets, patted and set loose. In the deep pocketed burrows of the bench, termite-size clones dream white directions to colour the tiredness of their somnambulistic donors. [End Page 223]The Stumbling Block is a barrel organ dragged to the site of a crime. Its tin cup catching rain as it judders on the pounding box. The moon is caught between its throat and the water, and in the black gleam of its varnished vibration. It spills dance into the causeways, sucking revelers along the spindle of its cranked tune. They will spin and curl their lumpen massed centrifuge around the bellowing thing. The laughter is momentary but has soaked away the blood, only the scuffs of shoes and the scratched cobbles sing on. [End Page 224]The Stumbling Block is not a coffer, disguised by a wig of artifice. It cannot offer erudition or... (shrink)

The human tumour suppressor protein p53 is critical for regulation of the cell cycle on genotoxic insult. When DNA is damaged by radiation, chemicals or viral infection, cells respond rapidly by arresting the cell cycle. A G1 arrest requires the activity of wild‐type p53, as it is not observed in cells lacking functionally wild‐type protein, and at least some component of S phase and G2/M arrests is also thought to be p53‐dependent. p53 functions as a transcription factor which binds (...) specific DNA sequences, and recently major downstream targets have been identified, including p21Cip1 an inhibitor of the cell cycle kinases that also blocks the replicative but not the repair function of DNA polymerase δ auxiliary factor, PCNA. Current interest focuses on developing novel cancer therapies based on our knowledge of the activity of p53 and p21Cip1 in the cell cycle. (shrink)

Polyploid cells contain multiple copies of all chromosomes. Polyploidization can be developmentally programmed to sustain tissue barrier function or to increase metabolic potential and cell size. Programmed polyploidy is normally associated with terminal differentiation and poor proliferation capacity. Conversely, non‐programmed polyploidy can give rise to cells that retain the ability to proliferate. This can fuel rapid genome rearrangements and lead to diseases like cancer. Here, the mechanisms that generate polyploidy are reviewed and the possible challenges upon polyploid cell division are (...) discussed. The discussion is framed around a recent study showing that asynchronous cell cycle progression (an event that is named “chronocrisis”) of different nuclei from a polyploid cell can generate DNA damage at mitotic entry. The potential mechanisms explaining how mitosis in non‐programmed polyploid cells can generate abnormal karyotypes and genetic instability are highlighted. (shrink)

The human mind is capable of entertaining an astounding range of thoughts. These thoughts are composed of concepts or ideas, which are the building blocks of thoughts. This book is about where all of these concepts come from and the psychological structures that ultimately account for their acquisition. We argue that the debate over the origins of concepts, known as the rationalism-empiricism debate, has been widely misunderstood—not just by its critics but also by researchers who have been active participants in (...) the debate. Part I fundamentally rethinks the foundations of the debate. Part II defends a rationalist view of the origins of concepts according to which many concepts across many conceptual domains are either innate or acquired via rationalist learning mechanisms. Our case is built around seven distinct arguments, which together form a large-scale inference to the best explanation argument for our account. Part III then defends this account against the most important empiricist objections and alternatives. Finally, Part IV argues against an extreme but highly influential rationalist view—Jerry Fodor’s infamous view that it is impossible to learn new concepts and his related radical concept nativism, which holds that essentially all lexical concepts are innate. Throughout the book, our discussion blends philosophical and theoretical reflection with consideration of a broad range of empirical work drawn from many different disciplines studying the mind, providing a thorough update to the rationalism-empiricism debate in philosophy and cognitive science and a major new rationalist account of the origins of concepts. [An open access title available under the terms of a CC BY-NC-ND 4.0 licence]. (shrink)

There is widespread agreement that while on a Dummettian theory of meaning the justified logic is intuitionist, as its constants are governed by harmonious rules of inference, the situation is reversed on Huw Price's bilateralist account, where meanings are specified in terms of primitive speech acts assertion and denial. In bilateral logics, the rules for classical negation are in harmony. However, as it is possible to construct an intuitionist bilateral logic with harmonious rules, there is no formal argument against intuitionism (...) from the bilateralist perspective. Price gives an informal argument for classical negation based on a pragmatic notion of belief, characterised in terms of the differences they make to speakers' actions. The main part of this paper puts Price's argument under close scrutiny by regimenting it and isolating principles Price is committed to. It is shown that Price should draw a distinction between A or ¬A making a difference. According to Price, if A makes a difference to us, we treat it as decidable. This material allows the intuitionist to block Price's argument. Abandoning classical logic also brings advantages, as within intuitionist logic there is a precise meaning to what it might mean to treat A as decidable: it is to assume A ∨ ¬A. (shrink)

PurposeWhite matter damage (WMD) was defined as the appearance of rough and uneven echo enhancement in the white matter around the ventricle. The aim of this study was to develop and validate a risk prediction model for neonatal WMD.Materials and MethodsWe collected data for 1,733 infants hospitalized at the Department of Neonatology at The First Affiliated Hospital of Zhengzhou University from 2017 to 2020. Infants were randomly assigned to training (n= 1,216) or validation (n= 517) cohorts at a ratio (...) of 7:3. Multivariate logistic regression and least absolute shrinkage and selection operator (LASSO) regression analyses were used to establish a risk prediction model and web-based risk calculator based on the training cohort data. The predictive accuracy of the model was verified in the validation cohort.ResultsWe identified four variables as independent risk factors for brain WMD in neonates by multivariate logistic regression and LASSO analysis, including gestational age, fetal distress, prelabor rupture of membranes, and use of corticosteroids. These were used to establish a risk prediction nomogram and web-based calculator (https://caowenjun.shinyapps.io/dynnomapp/). The C-index of the training and validation sets was 0.898 (95% confidence interval: 0.8745–0.9215) and 0.887 (95% confidence interval: 0.8478–0.9262), respectively. Decision tree analysis showed that the model was highly effective in the threshold range of 1–61%. The sensitivity and specificity of the model were 82.5 and 81.7%, respectively, and the cutoff value was 0.099.ConclusionThis is the first study describing the use of a nomogram and web-based calculator to predict the risk of WMD in neonates. The web-based calculator increases the applicability of the predictive model and is a convenient tool for doctors at primary hospitals and outpatient clinics, family doctors, and even parents to identify high-risk births early on and implementing appropriate interventions while avoiding excessive treatment of low-risk patients. (shrink)

Image restoration is a research hotspot in computer vision and computer graphics. It uses the effective information in the image to fill in the information of the designated damaged area. This has high application value in environmental design, film and television special effects production, old photo restoration, and removal of text or obstacles in images. In traditional sparse representation image restoration algorithms, the size of dictionary atoms is often fixed. When repairing the texture area, the dictionary atom will be (...) too large to cause blurring. When repairing a smooth area, the dictionary atom is too small to cause the extension of the area, which affects the image repair effect. In this paper, the structural sparsity of the block to be repaired is used to adjust the repair priority. By analyzing the structure information of the repair block located in different regions such as texture, edge, and smoothing, the size of the dictionary atom is adaptively determined. This paper proposes a color image restoration method that adaptively determines the size of dictionary atoms and discusses a model based on the partial differential equation restoration method. Through simulation experiments combined with subjective and objective standards, the repair results are evaluated and analyzed. The simulation results show that the algorithm can effectively overcome the shortcomings of blurred details and region extension in fixed dictionary restoration, and the restoration effect has been significantly improved. Compared with the results of several other classic algorithms, it shows the effectiveness of the algorithm in this paper. (shrink)

Taking its point of departure from Jullien’s primary claim in The Silent Transformations that ancient Greek ontology propels European thought into ‘the vertigo of the event,’ the article turns toward a European thinker whom Jullien does not mention in this context, namely Walter Benjamin, and asks whether his work, too, succumbs to this vertigo. The choice of Benjamin as a ‘test case’ is governed by two factors: while his work is widely associated with notions of the event, there is little (...) recognition of the degree to which he was engaged with the Daodejing (in translation) from the early 1910s to the late 1930s. Divided into four chronologically ordered sections, each of which is prefaced by a claim advanced in The Silent Transformations, the article shows how Benjamin’s concepts of transition, effective non-action (under the term ‘proletarian general strike’), mimesis, ‘the second technology,’ and Jetztzeit (‘now-time’) are all traversed by a mediated conception of the Dao. The primary question around this re-evaluation of his work, guided by the idea of ‘the silent transformations’ that Jullien adopts from Wang Fuzhi, is whether the theory of revolution Benjamin developed in the 1930s can be characterized as Daoist or, better yet, Marxist-Daoist. (shrink)

Leading animal models are powerful tools for translational research, but they also present obstacles. Poorly conducted preclinical research in animals is a common cause of translational failure, but even when such research is well-designed and carefully executed, challenges remain. In particular, dominant models may bias research directions, elide essential aspects of human disease, omit important context, or subtly shift research targets. Recognizing these stumbling blocks can help us find ways to avoid them: employing a wider range of models, incorporating more (...) realistic environmental conditions, better aligning studies between animals and patients, and focusing on human biology and therapeutic goals. Such changes are costly; but insisting it would be impractical or unrealistic to change strategies offers no way out of the current impasse. Rather, we must acknowledge the obstacles as well as the advantages presented by core models, and direct some of our investments in translational research toward getting around them. The dominance of biomedical research by a handful of animal models introduces subtle but significant obstacles to translation. Recognizing these obstacles is a critical first step toward finding ways around them; this paper describes how dominant models can create roadblocks, and suggests strategies to improve the efficiency of translation from animal models to humans. (shrink)

Medical research saves lives--yet all too often, it is thwarted by a review system supposed to safeguard patients that instead creates needless delays and expense. Institutional Review Boards, which exist at every hospital and medical school that conducts medical research, have ended up imposing such complex, draconian conditions that research is frequently damaged, delayed, and distorted. This is why medical miracles like the COVID-19 vaccines, which were developed at warp speed, are far too rare. Instead, medical research in countless (...) areas is kept at a horse-and-buggy pace. The result: unnecessary suffering and avoidable deaths. From Oversight to Overkill vividly recounts the story behind this crisis, one that remains unknown to the general public. Family physician and ethicist Simon Whitney shows how the IRB system was launched in response to scandals like the notorious Tuskegee syphilis study--and how, in recent decades, this well-intentioned program has become increasingly bureaucratic, convoluted, and stifling. Readers will learn how vital breakthroughs in treating conditions from kidney stones to heart attacks and premature birth have been delayed by IRB red tape, forcing doctors and patients to settle for less-effective treatments. They'll see how ill-informed demands from Congressional leaders that regulators "get tough" on scientists have caused respected research institutions to be shut down-with no benefit to the public. And they'll learn about a balanced, common-sense approach to reforming the system that can free scientists from pointless wheel-spinning while still protecting the public from the risks of unethical or careless experimentation. Until now, the debate about the IRB system's failures has been confined to specialty journals in medicine, law, and ethics. From Oversight to Overkill will finally alert citizens about this little-known crisis with America's medical research system-and what can be done about it. (shrink)

In this paper incomplete data sets, or data sets with missing attribute values, have three interpretations, lost values, attribute-concept values and ‘do not care’ conditions. Additionally, the process of data mining is based on two types of probabilistic approximations, global and saturated. We present results of experiments on mining incomplete data sets using six approaches, combining three interpretations of missing attribute values with two types of probabilistic approximations. We compare our six approaches, using the error rate computed as a result (...) of ten-fold cross validation as a criterion of quality. We show that for some data sets the error rate is significantly smaller (5% level of significance) for lost values, for some data sets the smaller error rate is associated with attribute-concept values, and sometimes with ‘do not care’ conditions. Again, for some approaches the error rate is significantly smaller for saturated probabilistic approximations than for global probabilistic approximations, while for some approaches it is the other way around. Thus, for an incomplete data set, the best approach to data mining should be chosen by trying all six approaches. (shrink)

Mutations in specific genes result in birth defects, cancer, inherited diseases or lethality. The frequency with which DNA damage is converted to mutations increases dramatically when the cellular genome is replicated. Although DNA damage poses special problems to the fidelity of DNA replication, efficient mechanisms exist in mammalian cells which function to replicate their genome despite the presence of many damaged sites. These mechanisms operate in either error‐prone or error‐free modes of DNA synthesis, and frequently involve DNA strand‐pairing reactions. (...) Genetic studies in yeast and other eukaryotes suggest that replication through DNA damage is highly regulated and catalysed by complex biochemical machineries composed of many specialised gene products. Knowledge of the molecular details by which such factors facilitate the replication of damaged DNA in mammalian cells should reveal basic rules about how DNA damage induces mutagenesis and carcinogenesis. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Art's DetourA Clash of Aesthetic TheoriesS. K. Wertz (bio)Both John Dewey1 and Martin Heidegger2 thought that art's audience had to take a detour in order to appreciate or understand a work of art. They wrote about this around the same time (mid-1930s) and independently of one another, so this similar circumstance in the history of aesthetics is unusual since they come from very different philosophical traditions. What (...) was it about the climate of the times that led them to such an idea? Is it still viable today? Both philosophers thought that art's audience is not in a position to immediately appreciate works of art—that we are missing something for a direct appreciation or apprehension—so we must take a detour. Why the detours and what are they? Are the detours similar? And are Dewey and Heidegger right about this? The essay that unfolds below attempts to answer these questions.First a definition is in order so we know what the term "detour" means when I use it. What is a detour? It is a deviation from a direct course or the usual procedure; a roundabout way temporarily replacing part of a route; in other words, a bypass or a roundabout way to some destination. The Little Oxford Dictionary adds a different twist on my characterization: "a course that leaves and rejoins [the] direct route."3 Applying this idea to art, we can say that a detour describes an audience who ordinarily perceives an artwork is a legitimate beginning for an appreciation of it, but that course must be bypassed for another (conception) before it can rejoin the direct route (perception). In other words, perceptions in the aesthetic experience must be aided by conceptions—a decidedly Kantian stance taken by Dewey and Heidegger. Their illustrations make my interpretation plausible.One of Heidegger's examples is Van Gogh's painting of a pair of peasant boots.4 He selects this painting to illustrate his metaphysics, which centers around the notion of "equipment." Peasant boots are equipment in [End Page 100] the sense that they are worn or used; the mere thing (like shoes or boots in a store [exhibited] or a closet [in storage]) disappears in use and becomes equipment. Between equipment and mere things—these two categories of being—are artworks. They are pictorial representations of equipment (in Heidegger's illustration; a pair of shoes as mere things could be a pictorial representation, like an advertisement, but it wouldn't be the same). Through the painted boots, a world comes into focus—a network of meaning. The world Heidegger sees in the Van Gogh painting is captured in the following descriptions: "In the vicinity of the [art]work we were suddenly somewhere else than we usually tend to be…. The art work let us know what shoes are in truth" (ATCR 233). So the nature of art is still a question about the nature of representation for Heidegger: it is what the shoes disclose to us about human existence. As he says, it is not just merely a pair of shoes portrayed but shoes "from the dark opening of the worn insides … the toilsome tread of the worker stares forth" (ATCR 232). In other words, we see the difficult labor that this particular owner toiled with in her daily chores.In Tralbaut's book, he quotes Heidegger in a caption alongside the painting: "Engraving in the intimate obscurity of the hollow of a boot is the weariness of the steps of work. The rough and solid weight of the clog tells of the slow and obstinate trudge across the fields."5 Heidegger continues in the same vein:In the stiffly rugged heaviness of the shoes there is the accumulated tenacity of her slow trudge through the far-spreading and ever-uniform furrows of the field swept by a raw wind. On the leather lie the dampness and richness of the soil. Under the soles slides the loneliness of the field-path as evening falls. In the shoes vibrates the silent call of the earth, its quiet gift of the ripening grain and its unexplained self-refusal in the fallow desolation of... (shrink)

In many countries, including patients are legally entitled to request copies of their clinical notes. However, this process remains time-consuming and burdensome, and it remains unclear how much of the medical record must be made available. Online access to notes offers a way to overcome these challenges and in around 10 countries worldwide, via secure web-based portals, many patients are now able to read at least some of the narrative reports written by clinicians (‘open notes’). However, even in countries (...) that have implemented the practice many clinicians have resisted the idea remaining doubtful of the value of opening notes, and anticipating patients will be confused or anxious by what they read. Against this scepticism, a growing body of qualitative and quantitative research reveals that patients derive multiple benefits from reading their notes. We address the contrasting perceptions of this practice innovation, and claim that the divergent views of patients and clinicians can be explained as a case of epistemic injustice. Using a range of evidence, we argue that patients are vulnerable to (oftentimes, non-intentional) epistemic injustice. Nonetheless, we conclude that the marginalisation of patients’ access to their health information exemplifies a form of epistemic exclusion, one with practical and ethical consequences including for patient safety. (shrink)

Following new scientific evidence, removal of the fallopian tubes or the ovaries, or both, are options for reducing the risk of ovarian cancer. This paper examines the new scientific evidence on the origin of ovarian cancer and argues that the removal of fallopian tubes or ovaries in high-risk patients for the purpose of reducing risk of cancer is not intrinsically disordered. Although a present and serious pathology may not exist, this removal constitutes an indirect sterilization, because (...) the immediate and primary effect is the reduction in risk of a pathological condition. This effect occurs immediately, directly, and effectively, and sterilization is a secondary effect. The paper then reflects on the subsequent inadequacy of the language of “present and serious pathology” given the new evidence on ovarian cancer. National Catholic Bioethics Quarterly 14.1 : 67–79. (shrink)

These days paradoxes seem to be all around us, constantly produced under the impetus of new technologies but tending to dissolve no less quickly at the instigation of these same technologies. Everything that was considered durable (concepts, organizations, ideas) tends to shift towards immediacy, as if long-term memory can and must become instantaneous memory. New technologies, especially the various networks and mobile telephones, fit less and less into established frames of reference. They go so far as to break with (...) the very notion of a frame, and thus place us in a movement of continuous and chaotic knowledge that the author has dubbed rheomorphism. The Web is increasingly oriented towards interaction among users, and the creation of rudimentary social networks that can provide content that makes good use of the network effects, with or without real visual and interactive rendering of web pages. In this sense, current websites act more as points of presence, or Web portals centred on the user rather than on traditional websites that were more or less static pages of data. (shrink)

Possession of a BRCA1 or BRCA2 gene mutation puts a woman at very high risk of developing breast and ovarian carcinoma at an early age. One treatment option is surgical removal of the target organs—breasts, ovaries, and fallopian tubes—before the malignancy develops. This risk-reduction surgery has been shown to significantly reduce the likelihood that a woman will develop one of these cancers. This paper argues that such surgeries do not violate Catholic moral principles, but can be justified using (...) the principles of double effect and totality and integrity. The paper does not recommend or endorse any specific treatment option. National Catholic Bioethics Quarterly 15.1 : 75–89. (shrink)

In his book Vital Conflicts in Medical Ethics: A Virtue Approach to Craniotomy and Tubal Pregnancies, Martin Rhonheimer offers a virtue approach to vital conflicts in medical ethics. These vital conflicts are those medical situations involving pregnancy in which, if nothing is done, both the mother and her child will die. When analyzed by means of his understanding of the virtue of justice, Rhonheimer concludes that the so-called direct killing of children in the womb or in the fallopian tube (...) is permissible since the child’s death is neither a means to saving the mother’s life nor an end sought for itself and is, therefore, not unjust. Because such a death is not unjust, it is also not a moral evil since only an unjust death can be called a moral evil. The author offers a critique of both his understanding of justice and what constitutes the “object” of the moral act. National Catholic Bioethics Quarterly 10.3 : 471–480. (shrink)

The Christian tradition has always taken a generally negative view of abortion, but the moral basis and perceived implications of this negative view have varied greatly. In the early Church abortion and contraception were often seen as broadly equivalent, both involving interference with the natural reproductive process (and an association with sexual immorality which even led some to see contraception as the more sinful of the two). But the tendency to conflate abortion with contraception, and even on similar grounds with (...) male masturbation, declined in the face of the biological discovery of the mother's role as more than just an incubator for the male "seed" - with the recognition of conception as a distinct and crucial event, abortion became generally seen as morally far more serious than contraception, potentially involving threat to an innocent life and therefore, arguably, equivalent to homicide. When seen as homicide, abortion has naturally been subject to an almost total prohibition, the only generally agreed exception being where it is necessary to save the mother's life. Within the Roman Catholic communion, moreover, even this exception has tended to be countenanced only when sanctioned by the doctrine of double effect - where the abortion is not directly intended, but is only a foreseen but unintended consequence of a surgical intervention whose primary intention is to save the mother's life (e.g. the removal of a cancerous uterus or of a fallopian tube containing an ectopic pregnancy). (shrink)

Medical literature on the protective effects of salpingectomy against ovarian cancer has challenged Catholic health care institutions to reexamine policies that prohibit tubal sterilization at the time of cesarean section. Salpingectomy performed for a woman whose fallopian tubes are known or suspected to have a serious and present pathology—risk-reducing salpingectomy—is morally justifiable as a therapeutic intervention. However, salpingectomy performed at the time of another medically indicated procedure, such as cesarean section, on an otherwise fertile woman whose fallopian (...) tubes are presumed to be healthy—opportunistic salpingectomy—constitutes direct sterilization and fails to meet the conditions of double effect. Moreover, until magisterial guidance clarifies the right application of Catholic teaching to the specific question of opportunistic salpingectomy, Catholic health care institutions should, out of prudential judgment and to avoid scandal, avoid establishing institution policies that permit the practice. (shrink)

This article concerns the interplay between two issues that involve both philosophy and neuroscience: whether the content of phenomenal consciousness is 'rich' or 'sparse', whether phenomenal consciousness goes beyond cognitive access, and how it would be possible for there to be evidence one way or the other.

Consciousness is a mongrel concept: there are a number of very different "consciousnesses." Phenomenal consciousness is experience; the phenomenally conscious aspect of a state is what it is like to be in that state. The mark of access-consciousness, by contrast, is availability for use in reasoning and rationally guiding speech and action. These concepts are often partly or totally conflated, with bad results. This target article uses as an example a form of reasoning about a function of "consciousness" based on (...) the phenomenon of blindsight. Some information about stimuli in the blind field is represented in the brains of blindsight patients, as shown by their correct "guesses," but they cannot harness this information in the service of action, and this is said to show that a function of phenomenal consciousness is somehow to enable information represented in the brain to guide action. But stimuli in the blind field are BOTH access-unconscious and phenomenally unconscious. The fallacy is: an obvious function of the machinery of access-consciousness is illicitly transferred to phenomenal consciousness. (shrink)

Wysocki (2024) is a critique of Block (2022). The present paper is a response to the former. We are in effect debating the best reaction to Nozick (1977) which criticized Austrian economics on the ground that it makes two claims that are incompatible with one another. On the one hand, the praxeological school is noted for its aversion to the concept of indifference. On the other hand, the Austrian school also accepts supply and demand curves, and diminishing marginal utility. These (...) three concepts imply homogeneous elements that comprise them. But if they are truly homogeneous, people ought to be indifferent between the different elements of them. Hence, the tension, not to say logical contradiction, in this perspective. Block (1980) was an attempt to respond to Nozick (1977). Hoppe (2005a,b; 2009) and Wysocki (2016; 2017; 2021; 2024) who supports Hoppe, maintain that Block’s refutation of Nozick (1977) was not efficacious at all, at worst, or at best, certainly not fully successful. Specifically, Wysocki maintains that there is a bifurcation between choosing and preferring; for example, no one is even aware of which foot goes first when entering a restaurant, and, yet, one has to make a choice about it. He avers that it is entirely possible to prefer to save either son, equally, while actually picking one, and not the other. (shrink)

Expanded edition with new chapters and updates to the translation and bibliography. Borges cites innumerable authors in the pages making up his life’s work, and innumerable authors have cited and continue to cite him. More than a figure, then, the quotation is an integral part of the fabric of his writing, a fabric made anew by each reading and each re-citation it undergoes, in the never-ending throes of a work-in-progress. Block de Behar makes of this reading a plea for the (...) very art of communication; a practice that takes community not in the totalized and totalizable soil of pre-established definitions or essences, but on the ineluctable repetitions that constitute language as such, and that guarantee the expansiveness—through etymological coincidences of meaning, through historical contagions, through translinguistic sharings of particular experiences—of a certain index of universality. This edition includes a new introduction by the author and three entirely new chapters, as well as updated images and corrections to the original translation. Lisa Block de Behar is Professor of Communications at the Universidad de la República in Montevideo, Uruguay and is a renowned Jorge Luis Borges scholar. William Egginton is Andrew W. Mellon Professor in the Humanities and Chair of the Department of German and Romance Languages and Literatures at Johns Hopkins University. He is the author of several books, including In Defense of Religious Moderation. Christopher RayAlexander is a graduate student and language instructor in the Department of German and Romance Languages and Literatures at Johns Hopkins University. (shrink)

The question of human nature has not been effectively addressed in our time because of great skepticism in the academic and philosophical discourses about the idea of social progress and the validity of a common humanity. As a result the question has been reduced by neoliberalism, biopsychology, and social psychology to demonstrating the malleability of humans in response to hierarchical, biological, or social-conformist pressures. To recover the concept of human nature it will be necessary to reconceptualize the dynamic of human (...) development as a feature of the modern and late modern achievements of a more evolved vision of individuality and community. (shrink)

Milton Friedman had long declared himself a small “l” libertarian. But, libertarianism is based on the twin pillars of the non aggression axiom and private property predicated on homesteading and peaceful exchange. Friedman adopts none of this. Instead, he undergirds his philosophy on “tolerance,” which is no part of libertarianism. Thus, his claim to the mantle of libertarianism, big or small “L” it matters not which, is called into question.

Apoptotic pathways have always been regarded as a key‐player in preserving tissue and organ homeostasis. Excessive activation or resistance to activation of cell death signaling may indeed be responsible for several mechanisms of disease, including malignancy and chronic degenerative diseases. Therefore, targeting apoptotic factors gained more and more attention in the scientific community and novel strategies emerged aimed at selectively blocking or stimulating cell death signaling. This is also the case for the TMEM219 death receptor, which is activated by a (...) circulating ligand, the Insulin‐like growth factor binding protein 3 (IGFBP3) and induces a caspase‐8‐dependent apoptosis of the target cells. Interestingly, stimulation of the IGFBP3/TMEM219 axis exerts an anti‐proliferative effect, while blockade of the TMEM219 deleterious signal protects TMEM219‐expressing cells of the endocrine pancreas, lung, and intestine from damage and death. Here, we summarize the most updated reports on the role of the IGFBP3/TMEM219 apoptotic axis in disease conditions, including intestinal disorders and diabetes, and we describe the advancements in designing and testing novel TMEM219‐based targeting approaches in emerging potential clinical applications. (shrink)

Walter Block leaned on 82 of the world's most prominent libertarian thinkers and asked them to tell their life stories with an eye to intellectual development. The result is the most comprehensive collection of libertarian autobiographies ever published. Their stories are thrilling and fascinating. They reveal their main influences, their experiences, their choices, and their ambitions. There are some very interesting lessons here for everyone. We learn what gives rise to serious thought about liberty and what causes a person to (...) dedicate a professional career or vocation to the cause. We also discover some interesting empirical information about the most influential libertarian writers. How people come to believe what they believe is a mysterious issue, but an important one to examine. The results have profound strategic implications for the future. If there is a theme that emerges here, it is that it is that the most powerful and effective message of liberty is the one that is both smart and truth telling, not the one that is evasive or consciously dumbed down. The two most influential libertarians that emerge from the contest here are Rothbard and Rand, and this is for a reason. This volume bears close study by anyone who is considering strategic issues. So far as we know, it is the first book of its kind, one sure to play a larger role in the future crafting of the message and scholarship of human liberty. (shrink)

Apoptosis is a physiological mechanism for the removal of unwanted or damaged cells. Apoptotic cells are rarely seen in living tissues, however, because of their rapid and efficient removal by phagocytosis. Phagocytotic cells such as macrophages or dendritic cells recognize apoptotic cells by specific changes of cell surface markers, which usually are not present on normal cells. One such event is the exposure of phosphatidylserine, which moves from the plasma membrane inner leaflet to the outer leaflet in preapoptotic cells. (...) An unresolved problem, however, was the nature of the phosphatidylserine receptor on the phagocytotic cells. In a recent issue of Nature, Fadok et al.(1) have reported the cloning of a phosphatidylserine receptor using an antibody raised against activated macrophages. Antibody treatment of these macrophages blocks this capacity to engulf. BioEssays 22:878–881, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

The transition from self-consciousness as the unhappy consciousness to reason as the critique of idealism is among the most important in Hegel’s Phenomenology of Spirit. Yet this transition is implicit and not readily discernible. This paper investigates whether we can discover and describe any roadblock that the unhappy consciousness is able to knock down, or despite which it is able to maneuver, and so become reason; or whether the unhappy consciousness arrives at an impassable dead end and either manages to (...) create a detour around it or just begins again, unexplained and unexplainably, almost ex nihilo, as reason; or whether, despite its implicitness, there exists a continuous, tenable, and unimpeded path from self-consciousness to reason. (shrink)

One of the most important issues concerning the foundations ofconscious perception centerson thequestion of whether perceptual consciousness is rich or sparse. The overflow argument uses a form of ‘iconic memory’ toarguethatperceptual consciousnessisricher (i.e.,has a higher capacity) than cognitive access: when observing a complex scene we are conscious of more than we can report or think about. Recently, the overflow argumenthas been challenged both empirically and conceptually. This paper reviews the controversy, arguing that proponents of sparse perception are committed to the (...) postulation of (i) a peculiar kind of generic conscious representation that has no independent rationale and (ii) an unmotivated form of unconscious representation that in some cases conflicts with what we know about unconscious representation. (shrink)

What is Functionalism? Functionalism is one of the major proposals that have been offered as solutions to the mind/body problem. Solutions to the mind/body problem usually try to answer questions such as: What is the ultimate nature of the mental? At the most general level, what makes a mental state mental? Or more specifically, What do thoughts have in common in virtue of which they are thoughts? That is, what makes a thought a thought? What makes a pain a pain? (...) Cartesian Dualism said the ultimate nature of the mental was to be found in a special mental substance. Behaviorism identified mental states with behavioral dispositions; physicalism in its most influential version identifies mental states with brain states. Functionalism says that mental states are constituted by their causal relations to one another and to sensory inputs and behavioral outputs. Functionalism is one of the major theoretical developments of Twentieth Century analytic philosophy, and provides the conceptual underpinnings of much work in cognitive science. (shrink)

Is consciousness based in prefrontal circuits involved in cognitive processes like thought, reasoning, and memory or, alternatively, is it based in sensory areas in the back of the neocortex? The no-report paradigm has been crucial to this debate because it aims to separate the neural basis of the cognitive processes underlying post-perceptual decision and report from the neural basis of conscious perception itself. However, the no-report paradigm is problematic because, even in the absence of report, subjects might engage in post-perceptual (...) cognitive processing. Therefore, to isolate the neural basis of consciousness, a no-cognition paradigm is needed. Here, I describe a no-cognition approach to binocular rivalry and outline how this approach can help resolve debates about the neural basis of consciousness. (shrink)

The "great debate" in cognitive science today is about the nature of mental images. One side says images are basically pictures in the head. The other side says they are like the symbol structures in computers. If the picture-in-the-head theorists are right, then computers will never be able to think like people.This book contains the most intelligible and incisive articles in the debate, articles by cognitive psychologists, computer scientists and philosophers. The most exciting imagery phenomena are described, phenomena that indicate (...) that mental images can be rotated and scanned, that smaller images are harder to see than larger ones, that when mental images are made larger they eventually overflow, that the "screen" they overflow from has a determinable shape (elliptical), and that this "screen" subtends a determinate visual angle, the angle of vision of the mind's eye.Such experiments cry out for explanation. If images are pictures in the head, who (or what) looks at them? Why haven't brain scientists found them? Such questions are the subject of the great debate.IMAGERY is an excellent choice for courses in cognitive psychology, perception: artificial intelligence, computer science; philosophy of mind, of psychology and of science; minds and machines, science and society.Contributors include: Roger Brown and Richard Herrnstein (on the work of Roger N. Shepard), Daniel Dennett, Jerry Fodor, Robert Schwartz, Stephen Kosslyn, Steven Pinker, George Smith, Steven Shwartz, and Zenon Pylyshyn,. (shrink)

Human behavior and thought often exhibit a familiar pattern of within group similarity and between group difference. Many of these patterns are attributed to cultural differences. For much of the history of its investigation into behavior and thought, however, cognitive science has been disproportionately focused on uncovering and explaining the more universal features of human minds—or the universal features of minds in general. -/- This entry charts out the ways in which this has changed over recent decades. It sketches the (...) motivation behind the cultural turn in cognitive science, and situates some of its central findings with respect to the questions that animate it and the debates that it has inspired. Woven throughout the entry are examples of how the cognitive science of culture, and especially its elevated concern with different forms of diversity and variation, continues to influence and be influenced by philosophers. -/- One cluster of philosophical work falls within the traditional subject matter of philosophy of science, in this case of the cognitive and social sciences. Philosophers have analyzed and assessed the methods and evidence central to the scientific study of cognition and culture, and have offered conceptual scrutiny, clarification, and synthesis. Research in a second vein sees philosophers themselves contributing more directly to cognitive scientific projects, (co)constructing theories, helping build computational models, even gathering empirical data. A third kind of work is naturalistic philosophy or philosophy of nature, wherein philosophers seek to use results from the cognitive science of culture to inform or transform debates over long-standing philosophical questions, including questions about the nature of philosophy and philosophical methodology itself. (shrink)

Often when there is no attention to an object, there is no conscious perception of it either, leading some to conclude that conscious perception is an attentional phenomenon. There is a well-known perceptual phenomenon—visuo-spatial crowding, in which objects are too closely packed for attention to single out one of them. This article argues that there is a variant of crowding—what I call ‘‘identity-crowding’’—in which one can consciously see a thing despite failure of attention to it. This conclusion, together with new (...) evidence that attention to an object occurs in unconscious perception, suggests there may be a double dissociation between conscious perception of an object and attention to that object, constraining the extent to which consciousness can be constitutively attentional. The argument appeals to a comparison between the minimal resolution (or ‘‘grain’’) of object-attention and object-seeing. (shrink)

This article compares the three frameworks for theories of consciousness that are taken most seriously by neuroscientists, the view that consciousness is a biological state of the brain, the global workspace perspective and an account in terms of higher order states. The comparison features the “explanatory gap” (Nagel, 1974; Levine, 1983) the fact that we have no idea why the neural basis of an experience is the neural basis of that experience rather than another experience or no experience at all. (...) It is argued that the biological framework handles the explanatory gap better than the global workspace of higher order views. The article does not discuss quantum theories or “panpsychist” accounts according to which consciousness is a feature of the smallest particles of inorganic matter (Chalmers, 1996; Rosenberg, 2004). Nor does it discuss the “representationist” proposals (Tye, 2000; Byrne, 2001a) that are popular among philosophers but not neuroscientists. (shrink)

Such claims are part 0f a viewpoint according t0 which mental images represent in thc manner of pictures. It is very natural t0 think that such claims are confused or nonsensical. One of my purposes here is a limited dcfcnsc of this supposedly confused doctrine, especially against its chief cognitive science rival. But this..

There has been considerable debate among philosophers and psychol- ogists about whether the internal representations of imagery represent in the manner of pictures or in the manner of language. One side, pictorialism,holds that an internal imagery representation of Reagan is like a picture of Reagan. The other side, descriptionalism,holds that an internal imagery representation of Reagan is more like a string of words denoting or describing Reagan. My aim here is to expose a widespread fallacy on the part of the (...) descriptionalists. In the course of so doing, I try to clarify the pictorialist position, and show how it can undercut what appears to be a category of evidence for the other side. (shrink)