The paper describes the conservation and interpretation project directed by Tonkin Zulaikha Greer at the Port Arthur penal settlement in Tasmania. Focused on the 1849 Separate Prison, the physical and ideological centrepiece of the Port Arthur settlement, TZG’s brief was to provide a masterplan for the conservation, reconstruction and interpretation of the remaining built fabric.

The introduction maps five panoptic-shaped establishments in Australia's colonial history, as well as discusses how the convict industry in Australia developed a unique pattern, alternating out-door and in-door penal servitude. In-door confinement was modelled on a variety of influences, of which Bentham’s is one among many. The label Panopticon might appear inaccurate to describe these prisons, however it is still used today as the term is loaded with connotations with encapsulates some of the spirit of the penal colony.

The movement to try to close the ever-widening gap between demand and supply of organs has recently arrived at the prison gate. While there is enthusiasm for using executed prisoners as sources of organs, there are both practical barriers and moral concerns that make it unlikely that proposals to use prisoners will or should gain traction. Prisoners are generally not healthy enough to be a safe source of organs, execution makes the procurement of viable organs difficult, and organ donation (...) post-execution ties the medical profession too closely to the act of execution. (shrink)

Two main goals of the emerging field of neurocognitive poetics are the use of more natural and ecologically valid stimuli, tasks and contexts and providing methods and models allowing to quantify distinctive features of verbal materials used in such tasks and contexts and their effects on readers responses. A natural key element of poetic language, metaphor, still is understudied insofar as relatively little empirical research looked at literary or poetic metaphors. An exception is Katz et al.’s corpus of 204 literary (...) metaphors by authors such as Shakespeare or Dylan Thomas, for which various rating data are available. We reanalyzed their corpus using a combination of quantitative narrative analysis, latent semantic analysis, and machine learning in order to identify relevant features of the metaphors that influenced the ratings. The combined application of computational tools sheds light on surface and affective-semantic features that co-determine the reception of poetic metaphors and successfully predicted the period of origin, authorship and goodness ratings of the metaphors. The present results can be used for generating quantitative hypotheses or selecting and matching verbal stimuli in empirical studies of literature and neurocognitive poetics. (shrink)

Using a close reading of a single clause and its context in a section in A Pluralist Universe, we see the moral dangers James saw in traditional ontology, in particular its relation to war and peace. This analysis opens up James’s combining the personalist philosophy of his friend Borden Bowne (and others) with the pluralism he developed late in his career. This leads, further, to reflection of James’s performative philosophizing. Finding in James a theory of “pluralistic personalism” gives us a (...) fresh look at the far-reaching power of his basic concepts of moral philosophy. (shrink)

If social relations often require the choice of a cooperative solution to a prisoners' dilemma, we must ask how people generally solve the games. Three possible devices are that those who choose non-cooperative strategies get a bad reputation and so learn to be cooperative, that people are taught by parents that non-cooperators have unhappy lives, or that an official can be paid a salary to make the cooperative choice. By analyzing erotic love and marriage, and why people try to do (...) their jobs, it is suggested that these devices result in people often solving prisoners' dilemma games without being conscious of them. How then do these structures that 'have the function' of solving prisoners' dilemmas get created and maintain themselves? It is suggested that Deweyan consciousness, existing only when structural strains or unsolved games create personal problems, is adequate to explain many such functional structures. (shrink)

BackgroundIn December 2014, China announced that only voluntarily donated organs from citizens would be used for transplantation after January 1, 2015. Many medical professionals worldwide believe that China has stopped using organs from death-row prisoners.DiscussionIn the present article, we briefly review the historical development of organ procurement from death-row prisoners in China and comprehensively analyze the social-political background and the legal basis of the announcement. The announcement was not accompanied by any change in organ sourcing legislations or regulations. As a (...) fact, the use of prisoner organs remains legal in China. Even after January 2015, key Chinese transplant officials have repeatedly stated that death-row prisoners have the same right as regular citizens to “voluntarily donate” organs. This perpetuates an unethical organ procurement system in ongoing violation of international standards.ConclusionsOrgan sourcing from death-row prisoners has not stopped in China. The 2014 announcement refers to the intention to stop the use of organs illegally harvested without the consent of the prisoners. Prisoner organs procured with “consent” are now simply labelled as “voluntarily donations from citizens”. The semantic switch may whitewash sourcing from both death-row prisoners and prisoners of conscience. China can gain credibility only by enacting new legislation prohibiting use of prisoner organs and by making its organ sourcing system open to international inspections. Until international ethical standards are transparently met, sanctions should remain. (shrink)

Determinism is established in quantum mechanics by tracing the probabilities in the Born rules back to the absolute (overall) phase constants of the wave functions and recognizing these phase constants as pseudorandom numbers. The reduction process (collapse) is independent of measurement. It occurs when two wavepackets overlap in ordinary space and satisfy a certain criterion, which depends on the phase constants of both wavepackets. Reduction means contraction of the wavepackets to the place of overlap. The measurement apparatus fans out the (...) incoming wavepacket into spatially separated eigenpackets of the chosen observable. When one of these eigenpackets together with a wavepacket located in the apparatus satisfy the criterion, the reduction associates the place of contraction with an eigenvalue of the observable. The theory is nonlocal and contextual. Keywords:. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:"To make a difference...":Narrative Desire in Global MedicineByron J. Good and Mary-Jo DelVecchio GoodIf, as Arthur Frank (2002) writes, "moral life, for better and worse, takes place in storytelling," this collection of narratives written by physicians working in field settings in global medicine gives us a glimpse of some aspects of moral experience, practice, and dilemmas in settings of poverty and low health care resources. These essays are (...) written from the midst of practice, in diverse settings in Africa, South Asia, Latin America, the Caribbean, and the United States. The majority of the writers are practitioners of contemporary 'global medicine'—physicians from North America or Europe who spend part of their lives flying into settings of poverty or special need to practice medicine and work with on-going collaborative clinical and public health systems—while a smaller number are working in the societies in which they were born. Although a few work for classic humanitarian organizations or have developed their own local NGO's, the great majority are engaged in the 'hybrid life' described by Robert Riviello and noted by Renée Fox, moving between academic medical centers and distant health care systems that are supported by local governments, major international organizations and funding agencies, and international NGO's like Partners in Health. These diverse forms of practice have become a common model for contemporary clinicians engaged in what has emerged as a new discipline of global health or global medicine, and these narratives give us a glimpse of some of the enduring, as well as newly emerging, forms of moral practice and ethical dilemmas characteristic of today's global medicine.Many of these stories are filled with the tension and pathos that makes clinical narratives powerful to read. Physicians are forced to make unfathomable decisions about whether to resuscitate and keep a baby alive, using all means available, or to let the infant die, whether to carry out a procedure that will save an infant in birth but would put the mother at risk, about how to deal with a cancer found in a very advanced state. However, virtually all of the stories transcend these classical stories of the decisions physicians are forced to make by being placed in settings of great scarcity of resources, which stand in particular contrast to the academic medical settings in North America or Europe where many of these global medicine specialists have trained and many continue to practice. The unspeakable inequality of resources emerges throughout these narratives as a kind of master theme, as the underlying moral, as opposed to plot, which gives meaning and sense to the stories. For those who practice medicine in such settings, global inequalities and scarcity of medical resources are deeply felt. They produce the rage that Jeffrey Deal describes. ("I learned to despise American churches during that time, a time when my world encompassed a dying newborn in Sudan, as well as the air conditioned padded seats [End Page 121] of our affluent suburban church.") They produce the distinctive experiences of helplessness and pain felt by clinicians who cannot separate how they would be able to treat such a patient at home from how they have to practice in these settings. For those clinicians working in their own societies, scarcity of resources often produces deep anger at the corrupt governments that fail to support basic human services for the great majority of their population. ("We were temporary actors performing in the cynical play of scarcity on permanent display in Port-au-Prince," writes Haitian physician Paul Pierre about his experience prior to joining Partners in Health.)But for those who regularly travel back and forth across the divide between rich and poor, whether across national boundaries or within their own society, the challenge to live a moral life is unendingly complicated. While becoming a part of a struggle for global justice with colleagues and advocates from both sides of the divide, few of the narrators can avoid personal feelings of ambivalence and guilt at being able to easily move from one side of that divide to the other back home. Many fantasize about giving up their lives in the north to devote themselves... (shrink)

Before establishing his mature interpretation of infinitesimals as fictions, Gottfried Leibniz had advocated their existence as actually existing entities in the continuum. In this paper I trace the development of these early attempts, distinguishing three distinct phases in his interpretation of infinitesimals prior to his adopting a fictionalist interpretation: (i) (1669) the continuum consists of assignable points separated by unassignable gaps; (ii) (1670-71) the continuum is composed of an infinity of indivisible points, or parts smaller than any assignable, with no (...) gaps between them; (iii) (1672- 75) a continuous line is composed not of points but of infinitely many infinitesimal lines, each of which is divisible and proportional to a generating motion at an instant (conatus). In 1676, finally, Leibniz ceased to regard infinitesimals as actual, opting instead for an interpretation of them as fictitious entities which may be used as compendia loquendi to abbreviate mathematical reasonings. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Arthur A. Krentz DRAMATIC FORM AND PHILOSOPHICAL CONTENT IN PLATO'S DIALOGUES AN intriguing innovation in the history of philosophical discourse is Plato's employment ofdramatic dialogues as his deliberately chosen means ofcommunication. Throughout the history of philosophy scant attention has been focused on this feature of Plato's works. Recently, however, some students of Plato's writings contend that it is crucial for interpreters to give careful attention to the dialogue (...) form in order to reach an essential understanding of the philosophical content. Thus WernerJaeger, commenting in 1934 on the importance of the form of Aristotle's philosophical works, mentions as an aside that, "Even in the case of Plato, the importance of the form for the understanding of his particular thought has often been overlooked for long periods; departmental philosophers and students ofliterature in particular are always prone to consider it as something literary which had no material significance for Plato, in spite of the fact that it is unique in die history of philosophy. By now, however, most persons know mat the study of the development of the form ofhis writing is one of me main keys to a philosophical understanding of him." ' In spite ofJaeger's contention that most contemporary interpreters of Plato are aware of the significance of investigating the dramatic form for an understanding of a dialogue's content, a survey of the literature on Plato shows that interpreters often abandon such a concern in their own approach to his dialogues. For example, many interpreters treat dialogues as treatises, ignoring the dramatic features in order to concentrate on the examination of the logical, epistemológica!, ethical or other philosophical aspects of the argumentation in a single dialogue or group ofdialogues; as a result interpreters tend to separate the content from the form of Plato's works.2 The effect of this approach is one-sided, for, although such interpretations attempt to do justice to the arguments, they ignore the dramatic features of the dialogues and their bearing on an interpretation of die philosophical substance. Currently a growing number of interpreters of Plato in Europe and North America hold that a consideration of the form of Plato's dialogues is important 32 Arthur A. Krentz33 for an understanding oftheir content and philosophical message.3 1 am in agreement with this position and in this article I consider some reasons that may have led Plato to adopt dialogue as his medium of philosophical expression and attempt to show how attention to the dialogue form shapes the interpretation of their content. Unlike his philosophical predecessors who cast their writings in the form of extended poems, aphorisms, or treatises "On Nature," Plato wrote dramas. That the dramatic form ofhis writings is not incidental to his philosophical purposes becomes apparent as one considers how Plato presents philosophy in a fundamentally different way from that of his predecessors and successors who adopted the essay and treatise as the paradigm ofphilosophical communication. In a philosophical work such as a treatise, an author ordinarily attempts to state his own position on issues under discussion as clearly and as forcefully as possible. This, however, is not the primary aim of Plato's works, for certain features of his dramas indicate that he deliberately concealed his own views. Of special note in this regard is the fact that Plato never speaks on his own behalf in the discourses he creates. There is no character named "Plato" unequivocally declaring the author's own position.4 Instead a variety of interlocutors ask questions, investigate philosophical problems, and puzzle over solutions while Plato remains noticeably silent. This silence of Plato indicates that he did not regard the unequivocal presentation of his own views to be of paramount importance. If this had been his aim, Plato had only to write a dialogue which included himselfas one ofthe characters clearly stating his own position. Having engaged in many philosophical discussions with Socrates and with his own students, Plato could have written a dialogue based on such conversations. His not doing so is sufficient to show that he did not use his writings as a primary vehicle for transmitting his own position in his own words. Nor did Plato use... (shrink)

In 1924, Bohr, Kramers and Slater tried to introduce into microphysics conservation principles that hold only on the average. This attempt was abandoned in the light of the Compton-Simon experiment. Since that time, except for a moment of doubt in 1936, it has been thought that the classical conservation laws hold in quantum theory for each individual interaction, in a way that yields the classical exchange-and-balance of momentum familiar from the laws of elastic collisions. It has been thought, that is, (...) that in each individual “collision” what one part of the total system loses in linear momentum another part gains, so as to maintain the same total amount afterwards as before. To those familiar with discussions of the interpretation of quantum theory, however, it will be apparent that the very concepts needed to express this idea of an elastic collision are generally not admitted in the theory. For one needs the idea that both before and after collision the total system has a well-defined value for the conserved quantity and, moreover, that the various component parts of the system have well-defined values for those quantities out of which the conserved one is composed. But in the case of spin, for example, it is customary to say that although total spin may be conserved in certain interactions one cannot attribute values to the separate components of spin because the associated operators do not commute. Moreover, one does not generally refer to the values of quantities except in eigenstates. Hence, in general, one would not refer to the value of the conserved quantity before and after interaction, except for interactions initiated in eigenstates. (shrink)

The weather can be very cold at Dachau concentration camp, but Dachau was apparently not cold enough for some Nazi purposes. A camp doctor named Rascher wrote to Heinrich Himmler in February 1943, asking to be transferred to Auschwitz to continue his experiments—which involved freezing live prisoners. The letter reads: “Auschwitz is more suitable [than Dachau] as it is colder there and the camp itself is much larger, thereby attracting less attention to the test persons, who tend to scream while (...) freezing.”. (shrink)

For decades The People’s Republic of China has been expanding its capacity to perform organ transplants, primarily kidneys and livers but also hearts, lungs and multiorgan transplants. The annual number of organ transplants performed is estimated to be over 30 000. The number is expected to grow with a projected market for immunosuppressants expected to be over ¥30 billion/$4.3 billion by 2024.1 China is second only to the USA and is expected to become the country with the largest number of (...) organ transplants by 2021 or 2022. Many transplants are performed on Chinese citizens but an active market in transplants for ‘tourists’ is ongoing.2 The source of the supply of organs to fuel this rapid growth has long been suspect.3 China had no system for obtaining organs for many years from cadaver sources making it impossible to credit claims that gifts from the newly dead were the sole or even majority source of transplantable organs. Critics, including myself, have long alleged that the only possible source of organs for both Chinese citizens and transplant tourists are executed prisoners. Many accounts, commissions and investigations have confirmed an immoral reliance on this vulnerable …. (shrink)

THIS essay is concerned with two theses about enjoyment to be found in William of Ockham: Enjoyment is a certain kind of love, and Enjoyment is a cause of pleasure, not the same thing as pleasure or an effect of it. Its own thesis is that Ockham’s extensive discussions of such topics in human nature as love, pleasure, and volition, as well as cognition, deserve not only more attention but more varied attention than they typically receive: Ockham can fruitfully be (...) read as a contemporary philosopher of mind, as a pre- and possibly super-Humean founder of behavioral science, and as a committed philosophical theologian ; further, in each of these ways he can well be taken either in the abstract or as a pivotal historical figure in such larger late medieval-early modern movements of thought as involve a conception of what human beings are and what they can or should do. In view of this spread of aspects, one might wish for a unifying definition of Ockham’s own essential philosophical-psychological nature. The present study is not intended to provide such a definition. Its aim, rather, is to present Ockham as a sort of intellectual revolving door between positions, disciplines, and philosophical concerns which are now largely separated, or as a craggy mountain standing between secular or "modern" thought and vast but nebulous ranges of ideas looming in the distance beyond. An affinity for such ideas is not, to be sure, exclusively medieval, yet Ockham’s peculiar position as a defender of traditional spiritual truths and values who at the same time inaugurated an eminently influential via moderna in philosophy and theology suggests that we may find vantage points in his work for insights not easily available elsewhere. Whether we in corporate these into a system like Ockham’s, or a different system, or no system may be less important than seeking the insights in the first place. (shrink)

One observes regulation at every biological level. Organisms, cells, and biochemical processes operate efficiently, normally wasting neither material nor energy, and adjusting their functions to external influences. Nature evidently has evolved mechanisms specifically dedicated to regulation at many levels. What is the molecular basis of this control?In the 1950s these molecular control mechanisms began to be explored seriously. The discoveries of feedback inhibition of enzyme activity were important because they gave an initial example of how regulation is achieved at the (...) molecular level. We showed that certain enzymes are composed of two parts, one for catalysis and another distinct part present only to regulate this catalysis. Catalytic activity can be either stimulated or inhibited when a small molecule in the environment combines with the enzyme's regulatory site. In particular, a final product of a metabolic pathway generates a feedback loop which automatically limits its own excessive production, by combining with the regulatory site of an early enzyme in that pathway. Later studies showed that catalytic and regulatory structures of some enzymes could be separated physically.The discovery of regulatory sites and their interaction with molecules unrelated to their substrates was the basis for the generalized allosteric concept. This concept extends the regulatory site idea to a wide variety of processes such as control of gene expression, hormone action, and cellular growth. (shrink)

We show that from a supercompact cardinal $\kappa$, there is a forcing extension $V[G]$ that has a symmetric inner model $N$ in which $\mathrm {ZF}+\lnot\mathrm {AC}$ holds, $\kappa$ and $\kappa^{+}$ are both singular, and the continuum function at $\kappa$ can be precisely controlled, in the sense that the final model contains a sequence of distinct subsets of $\kappa$ of length equal to any predetermined ordinal. We also show that the above situation can be collapsed to obtain a model of $\mathrm (...) {ZF}+\lnot\mathrm {AC}_{\omega}$ in which either $\aleph_{1}$ and $\aleph_{2}$ are both singular and the continuum function at $\aleph_{1}$ can be precisely controlled, or $\aleph_{\omega}$ and $\aleph_{\omega+1}$ are both singular and the continuum function at $\aleph_{\omega}$ can be precisely controlled. Additionally, we discuss a result in which we separate the lengths of sequences of distinct subsets of consecutive singular cardinals $\kappa$ and $\kappa^{+}$ in a model of $\mathrm {ZF}$. Some open questions concerning the continuum function in models of $\mathrm {ZF}$ with consecutive singular cardinals are posed. (shrink)

We explore Woodin's Universality Theorem and consider to what extent large cardinal properties are transferred into HOD (and other inner models). We also separate the concepts of supercompactness, supercompactness in HOD and being HOD-supercompact. For example, we produce a model where a proper class of supercompact cardinals are not HOD-supercompact but are supercompact in HOD. Additionally we introduce a way to measure the degree of HOD-supercompactness of a supercompact cardinal, and we develop methods to control these degrees simultaneously for (...) a proper class of supercompact cardinals. Finally, we also produce a model in which the unique supercompact cardinal is also the only strongly compact cardinal, no cardinal is supercompact up to an inaccessible cardinal, level by level inequivalence holds and the unique supercompact cardinal is not HOD-supercompact. (shrink)

In this paper I attempt to trace the development of Gottfried Leibniz’s early thought on the status of the actually infinitely small in relation to the continuum. I argue that before he arrived at his mature interpretation of infinitesimals as fictions, he had advocated their existence as actually existing entities in the continuum. From among his early attempts on the continuum problem I distinguish four distinct phases in his interpretation of infinitesimals: (i) (1669) the continuum consists of assignable points separated (...) by unassignable gaps; (ii) (1670-71) the continuum is composed of an infinity of indivisible points, or parts smaller than any assignable, with no gaps between them; (iii) (1672-75) a continuous line is composed not of points but of infinitely many infinitesimal lines, each of which is divisible and proportional to a generating motion at an instant (conatus); (iv) (1676 onward) infinitesimals are fictitious entities, which may be used as compendia loquendi to abbreviate mathematical reasonings; they are justifiable in terms of finite quantities taken as arbitrarily small, in such a way that the resulting error is smaller than any pre-assigned margin. Thus according to this analysis Leibniz arrived at his interpretation of infinitesimals as fictions already in 1676, and not in the 1700's in response to the controversy between Nieuwentijt and Varignon, as is often believed. (shrink)

Some words enter the language with an uncommon aptitude both for uniting things already observed but formerly severed by separate terms and for fostering the recognition of things unnoticed before. Indeed, they often unite things that ought still to be left discrete; and even among those properly united, clarity may require the acknowledgment of many distinctions. I shall here consider such a term and the various kinds of things to which it can and cannot refer: projection.

The following is an analysis of the relationship between incompatibility, conflict and breakdown. It is restricted to situations of a certain sort — to the isolation of the conditions under which breakdowns occur. These conditions are specific and defineable. Under certain circumstances incompatibilities and conflicts culminate in growth, under others in separation, under others in outright destruction of one of the incompatible elements, under others still in dominance-subserviance relationships and under others in breakdown. This is a matter of some importance (...) since influential current conceptions treat incompatibility and conflict as though they were uniform in outcome. The followers of Hegel regard them as always making for growth whereas certain contemporaries look upon them as the prime movers of breakdown and decline. The truth of the matter would seem to be that neither of these theories is correct. Conflicts vary, their consequences vary and the conditions under which they occur vary. For empirical analysis the important thing is the disengagement of the differences making for different culminations as well as the relations common to all; and the working out, as far as possible, of the way in which alterations in certain basic factors make for changes in result. A specific analysis of this sort may be valuable for foresight and even for a degree of control where the conditions are accessible to our manipulation. (shrink)

Like most other subjects under discussion today, the theory of nature is largely controlled by considerations of knowledge. Treatment of it is, consequently, incidental to the treatment of these other problems, and is undertaken, in the main, because they compel it. A brief catalogue of characteristic statements about nature will illustrate this. “Nature,” says one writer, “is that which we observe in perception through the senses”; and another writes, “It is not experience which is experienced, but nature—stones, plants, animals, diseases, (...) health, temperature, electricity, and so on.” Nothing is more apparent in these sentences than the fact that it is not nature that the writers are so much concerned with, as with what it is that appears through the senses. The theory of nature, that is, is not so much guided by an analysis of the word's context and usage, as it is by the question: what is the proper object of knowledge? Consequently it is the latter question that is answered and not the question: what is nature? The reason for this is evident in the purpose of these statements and in their history; their purpose: the desire to do away with the separation between experience and nature, and to transform nature into a field familiar and accessible; and their history: the very framework against which they are directed, for they are embedded in the set-up from which they are trying to disentangle themselves. Perhaps something ought to be said to substantiate the thesis that the sentences cited are controlled by the problem of knowledge, especially since their intent seems to be to escape that problem. In any case, their history should serve to clarify them, and render a different approach to the theory of nature more significant. (shrink)

Pickering & Garrod (P&G) suggest that communicators synchronize their processing at a number of linguistic levels. Whereas their explanation suggests that representations are being compared across individuals, there must be some representation of all conversation participants in each participant's head. At the level of the situation model, it is important to maintain separate representations for each participant. At other levels, it seems less crucial to have a separate representation for each participant. This analysis suggests that different mechanisms may (...) synchronize representations at different linguistic levels. (shrink)

Logicism and the Philosophy of Language brings together the core works by Gottlob Frege and Bertrand Russell on logic and language. In their separate efforts to clarify mathematics through the use of logic in the late nineteenth and early twentieth century, Frege and Russell both recognized the need for rigorous and systematic semantic analysis of language. It was their turn to this style of analysis that would establish the philosophy of language as an autonomous area of inquiry. This anthology (...) gathers together these foundational writings, and frames them with an extensive historical introduction. This is a collection for anyone interested in questions about truth, meaning, reference, and logic, and in the application of formal analysis to these concepts. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Power of “Pliant Stuff”: Fables and Frankness in Seventeenth-Century Dutch RepublicanismArthur WeststeijnIn the preface to his 1609 collection of classical fables entitled De sapientia veterum (On the Wisdom of the Ancients), Francis Bacon vindicated his choice for such a playful genre. Although the writing of fables might seem just an “exercise of pleasure for my own or my reader’s recreation,” Bacon stressed that that was not the case. (...) On the contrary, he argued that “beneath no small number of the fables of the ancient poets there lay from the very beginning a mystery and an allegory.” Therefore, he continued, through such fables, “as sacred relics and light airs breathing out of better times,” hidden meanings can be exposed and made understood to unskilled ears and eyes. Indeed, “the employment of parables as a method of teaching, whereby inventions that are new and abstruse and remote from vulgar opinions may find an easier passage to the understanding,” shows that the fable serves as a very appropriate expedient for instruction and persuasion, the higher goals of rhetoric beyond simple entertainment and delight.1 [End Page 1]Yet, for all these noble purposes, Bacon could not hide his unease with those aspects of the fable which seemed to escape his pen’s command. Embarrassed by the “levity and looseness with which people indulge their fancy in the matter of allegories,” he acknowledged himself to have trod slippery ground. As he asserted: “I know very well what pliant stuff fable is made of, how freely it will follow any way you please to draw it, and how easily with a little dexterity and discourse of wit meanings which it was never meant to bear may be plausibly put upon it.” For Bacon, this intrinsic ambivalence of the fable gave rise to discomfort, and from the start he sought to remove any potential misunderstandings about his intentions. However, not all seventeenth-century writers of fables shared his concerns. Instead, the very nature of the fable as “pliant stuff,” as a genre which necessarily conveys meanings in an ambiguous, suggestive, and indirect manner, made it a particularly useful rhetorical device for those who would not or could not articulate their opinions openly.This article shows that a number of seventeenth-century authors deliberately employed the fable for its political expediency as an opaque prism to diffuse unconventional ideas that could undermine authority. Central in this overview are the Dutch merchants and fervent republican theorists Johan and Pieter de la Court, the main representatives of the radicalization of Dutch republicanism in the decades following the Peace of Westphalia. While most mainstream republicans in the Netherlands emphasized the need of a monarchical figure, a Stadholder, in the ideally balanced republican regime, the brothers De la Court claimed that such a monarchical element would necessarily entail tyranny.2 Their writings employed two different types of fables to substantiate this fundamental claim: the first based on the political allegories of the Italian satirist Traiano Boccalini, the second following the Aesopian tradition as exemplified by the famous [End Page 2] Dutch poet and playwright Joost van den Vondel. Through an analysis of the rhetorical role of these fables, this article attempts to shed more light on the reasons why fables were used in seventeenth-century republican thought. It will argue that the literary aspects of the fable cannot be separated from its political function, a function that eventually can be characterized as highly paradoxical: not in spite but because of its openness to different readings, the fable involved a disguised rhetorical plea for frankness and liberty of speech.Rhetoric and Fables: The Standing of an Emblematic GenreIn classical antiquity, when authors such as Aesop and Phaedrus had created a distinct genre of allegorical tales, the use of such fables had been as much reproved as their particular rhetorical force had been recognized. According to Quintilian, fables should not be a part of the linguistic armory of the truly decent orator, for fables “are specially attractive to rude and uneducated minds, which are less suspicious than others in their receptions of fictions and, when pleased, readily agree with the arguments from which their pleasure is derived... (shrink)

84 B. ζῆν τε οῐεται οὕτω δεῖν … καὶ… ἀϕικομένη ἀπάλλαττεσθαι. Surprise has been expressed at this nominative after οἲεται δεῖν. Cf. Magna Moralia II. xi. 31, οὐκοἲ ονται δεῖν αὐτοι ϕιλεῖν ἀλλ ὑπὸ τῶν ἐνδεεστέρων οἲονται δεῖν αὐϒοῖ ϕιλεῖσθαι. Herodian Hist. I. X. 4, ῲήθη δεῖν μέϒα τι δράσας κατορθῶσαι. Isocrates ix. 30, οὐΧ ἠϒήσαϒο δεῖν χωρίον καταλαβὼν και τὸ σῶμα ἐν ἀσϕαλείᾀ καταστήσας περιιδειν.… Either such phrases were so common that οἲομαι δεῖν came to be thought of as (...) a single word, in which δεῖν did not count, or else this use comes from adding δεῖν superfluously to a primitive use of οἲομαι with an infinitive. It is of course common enough to say οἲομαι ϕιλεῖν in good Attic for ‘I think fit to love.’ I should prefer the latter hypothesis myself: οῐομαι is properly to ‘carry’ or ‘bear’ so οἲομαι ϕιλείν is ‘I propose to love,’ and then δεῖν was added, especially when οἲομαι had come to mean ‘I think.’ There is a good instance of the primitive use of οἲω in Odyss. xix. 312, ῶδʹἀνὰ θυμὸν οἲεται surely this is simply ‘it is borne in upon my mind,’ ‘je suis porté à croir’. Anyhow οἲομαι or ἡ ϒοῦμαι δειν may be followed by a nominativeand infinitive. (shrink)

The work of Giorgio Agamben relies heavily on two rather opaque notions: the messianic and the irreparable. This essay is devoted to an analysis of the latter. After surveying the existing literature, I take my cue from Dietrich Bonhoeffer's prison letters and prepare the way for my own analysis of Agamben's irreparable. In the final part of the essay, I compare the irreparable with Agamben's use of Benjamin's thought of something unforgettable. I understand the role of the irreparable in (...) this light, since, for Agamben, it means the chance of something given up by language, something given up altogether, and as such serves as entry to the paradigmatic. (shrink)

La musique occupe une place singulière au sein de la philosophie de G.W. Leibniz (1646-1716). Si les développements que ce dernier y consacre sont peu nombreux et dispersés à travers son œuvre, ils n'en dessinent pas moins les contours d'une philosophie de la musique aussi pénétrante que méconnue. Celle-ci apparait tout à la fois comme l'expression et le modèle privilégié de sa métaphysique générale, dont la portée esthétique reste largement à explorer. Une œuvre en particulier, cependant, semble avoir déjà donné (...) corps à cette esthétique musicale. Cette œuvre est celle de Jean-Sébastien Bach (1685-1750), dont l'écriture contrapuntique manifeste plus que toute autre une parenté structurelle avec la philosophie de Leibniz. À scruter l'architecture complexe de ses compositions, on peut y déceler comme un miroir de l'univers leibnizien, une expression sensible des principes mêmes de l'harmonie universelle. Au vu du contexte intellectuel dans lequel évoluait J.-S. Bach, cette parenté n'est du reste pas sans fondement historique. Il n'est ici que de mentionner l'implication du Cantor dans la société philosophique dirigée par Lorenz Mizler (1711-1778), élève de Wolff et héritier de Leibniz, à laquelle il dédia plusieurs de ses œuvres les plus hautement formelles, dont la dernière, inachevée, devait être 'L'Art de la fugue'. À travers l'étude de la conception leibnizienne de la musique, envisagée dans son rapport à la pensée musicale de J.-S. Bach, cet ouvrage explore les relations entre métaphysique et musique à la lumière du concept d'harmonie comme "unité dans la diversité. (shrink)

Moral extremists argue for highly demanding duties of beneficence on the ground that accepting a more moderate position commits us to denying the common-sense moral intuition elicited by easy rescue cases. I argue that a moderate duty of beneficence is consistent with this intuition in light of what I call aggregationism, the view that the large aggregate cost of performing many low-cost acts of beneficence is relevant to what moral agents may do in cases where they face multiple low-cost occasions (...) to rescue. After demonstrating how the debate between moderates and extremists turns on the truth of aggregationism, I defend aggregationism against the challenge that it is inconsistent with respecting the separateness of persons. (shrink)

Esta resenha discute criticamente a obra Reflexões sobre a guilhotina, de Albert Camus (2022). Imerso em seu próprio cosmos de referência, o literato se ampara tanto em sua própria filosofia quanto em memórias pessoais para arquitetar a integridade de seus argumentos, os quais também são nutridos por uma plural literatura que aborda diretamente a temática da punição capital. Na tentativa de preencher uma lacuna, diagnosticada pelo próprio escritor argelino, na sociedade francesa, ele empreende neste ensaio uma demarcação argumentativa contrária à (...) pena de morte e sua aplicação, refutando os argumentos de seus defensores e oferecendo um novo horizonte à condição humana que era duplamente assassinada na escuridão das prisões francesas. Palavras-chave: Albert Camus; pena de morte; guilhotina; revolta; ressentimento. On the steps of the scaffold: a review of Reflections on the guillotine, by Albert Camus Abstract: This review critically discusses the work Reflections on the guillotine, by Albert Camus (2022). Immersed in his own cosmos of reference, the literate draws on both his own philosophy and personal memories to architect the integrity of his arguments, which are also nourished by a plural literature that directly addresses the issue of capital punishment. In an attempt to fill a gap, diagnosed by the Algerian writer himself, in French society, he undertakes in this essay an argumentative demarcation against the death penalty and its application, refuting the arguments of its defenders and offering a new horizon to the human condition which had been doubly murdered in the darkness of French prisons. Keywords: Albert Camus; death penalty; guillotine; revolt; resentment. Sobre los escalones del cadalso: una reseña de Reflexiones sobre la guillotina, de Albert Camus Resumen: Esta reseña analiza críticamente la obra Reflexiones sobre la guillotina, de Albert Camus (2022). Inmerso en su propio cosmos de referencia, el literato se sirve tanto de su propia filosofía como de sus recuerdos personales para construir la integridad de sus argumentos, que además se nutren de una literatura plural que aborda directamente el tema de la pena capital. En un intento por llenar un hueco, diagnosticado por el propio escritor argelino, en la sociedad francesa, emprende en este ensayo un deslinde argumentativo frente a la pena de muerte y su aplicación, refutando los argumentos de sus defensores y ofreciendo una nueva horizonte a la condición humana que fue doblemente asesinada en la oscuridad de las prisiones francesas. Palavras-clave: pena de muerte; guillotina; revuelta; resentimiento. Data de registro: 31/03/2022 Data de aceite: 17/05/2022. (shrink)

This paper examines the efficiency problem involved in experimental tests of so-called “local” hidden variables. It separates the phenomenological locality at issue in the Bell case from Einstein's different conception of locality, and shows how phenomenological locality also differs from the factorizability needed to derive the Bell inequalities in the stochastic case. It then pursues the question of whether factorizable, local models (or, equivalently, deterministic ones) exist for the experiments designed to test the Bell inequalities, thus rendering the experimental argument (...) against them incomplete. This leads to an investigation of the so-called “prism models” and to new inequalities for a significant class of such models, inequalities that are testable even at the low efficiencies of the photon correlation experiments. (shrink)

During the Italian campaigns of the French Revolutionary Wars (1796–1801), several epidemic outbreaks sparked acrimonious aetiological debates: were the fevers spread by soldiers and prisoners of war, or produced by environmental factors? This debate was not only a scientific issue, but also a political one, for causation was linked to accountability. Looking at a series of medical investigations written by French military practitioners, this paper argues that theories of contagion were used by civilians to accuse the army of spreading disease, (...) in what I describe as an “aetiology of blame.” Likewise, military officials attempted to absolve themselves of responsibility for the spread of disease by focusing on unwholesome environments, depicting diseases as unavoidable fatalities. Military doctors thus supported French imperial endeavours by obscuring the army's responsibility for the spread of diseases, putting forward aetiologies of fate and blaming individual behaviour. Even when they did not radically dismiss contagionist perspectives, military practitioners insisted on a wide range of pathogenic causes. Their discourses were in line with medical theories of the time, but they downplayed the responsibility of the army for the spread of diseases, which they depicted as a factor among others. Military doctors were thus not always involved in the direct and deliberate production of ignorance, but they did sustain controversies and uncertainty. (shrink)

Over 90% of the organs transplanted in China before 2010 were procured from prisoners. Although Chinese officials announced in December 2014 that the country would completely cease using organs harvested from prisoners, no regulatory adjustments or changes in China’s organ donation laws followed. As a result, the use of prisoner organs remains legal in China if consent is obtained. We have collected and analysed available evidence on human rights violations in the organ procurement practice in China. We demonstrate that the (...) practice not only violates international ethics standards, it is also associated with a large scale neglect of fundamental human rights. This includes organ procurement without consent from prisoners or their families as well as procurement of organs from incompletely executed, still-living prisoners. The human rights critique of these practices will also address the specific situatedness of prisoners, often conditioned and traumatized by a cascade of human rights abuses in judicial structures. To end the unethical practice and the abuse associated with it, we suggest to inextricably bind the use of human organs procured in the Chinese transplant system to enacting Chinese legislation prohibiting the use of organs from executed prisoners and making explicit rules for law enforcement. Other than that, the international community must cease to abet the continuation of the present system by demanding an authoritative ban on the use of organs from executed Chinese prisoners. (shrink)

I do not for a moment question the fact that many people have experiences of a special type which may be termed “religious”, The extent to which religious experience may be regarded as a reasonably common phenomenon in present-day Britain is shown clearly by David Hay in his Exploring Inner Space, Harmondsworth 1982. that such experiences often involve reference to something which appears to display a radical unlikeness to all else and that they are therefore in some sense inexpressible. Doubtless (...) the ideas I have put forward about the possible source of such unlikeness and ineffability might suggest models of God which would not find much theological approval, at least within any mainstream theistic tradition, since some sort of pantheism seems inevitably to be implied. But however this might be, the concept of radical unlikeness as it has been analyzed here can, I think, help us towards understanding certain problematic areas in religion quite apart from the issue of intelligibility, which has been the focus of this discussion. To begin with, radical unlikeness suggests a way in which the historical continuity of concepts of the transcendent might be upheld against the discontinuity suggested by the diversity of interpretations through which they have moved. Ancient and modern outlooks on, say, God differ enormously, as indeed do the range of co-temporal accounts at many particular moments. But, by and large, theologians firmly maintain that it is a single and unchanging phenomenon which is being dealt with. Unless we can point to some common element which is both specific enough to create a binding sense of common tradition, yet never completely expressed by any attempt at understanding it within that tradition (thus persistently demanding new attempts to apprehend it), then given the widely differing views of God within, for example, the Christian community, it is difficult to see how we could assume that in fact they all stemmed from the same source and were talking about the same thing. The idea of radical unlikeness could provide an element with just these required characteristics: it could be seen as what all the accounts attempt to net, with varying degrees of adequacy, within their offered interpretations. It could be seen as what remains constant, constantly elusive yet constantly generative of fresh attempts to apprehend it, throughout a history of intra-religious diversity. This sort of explanation could, presumably, be applied to the intra-religious diversity of the non-Christian traditions too.Secondly, radical unlikeness might suggest a possible way of understanding inter-religious diversity in a way which allows that whilst such diversity exists, whilst the differences between religions are real, they are grounded in a similar root-experience. It may, at first sight, seem difficult to continue thinking of the various religious traditions as truly separate phenomena if they are taken as being grounded on experiences whose ineffability stems from the unlikeness of experiencing things as a whole. Here we must stress again that if they are to be considered intelligible, radically unlike experiences cannot be considered completely so - or putting this another way, we cannot more than approach experience of totality. Sense can be given to religious claims of ineffability by suggesting experience of near totality, where we reach the last point on the scale of inclusiveness which complies with the logical criteria demanded of something for it to be possible for us to be aware of it. We might thus attempt an explanation of inter-religious diversity based on the view that Hinduism, Buddhism, Christianity, Islam etc. acquire their differences from the different elements included in their experience of near totality. Taking totality to be represented by the scale of one to ten, Hinduism might be seen as grounded on experience of 1-2-3-4-5-6-7-9-10, Buddhism on experience of 1-3-4-5-6-7-8-9-10 and so on. The resulting dissimilarities are thus centred not on different types of experience, but on different areas of inclusiveness. This is, of course, to suppose that the various religious traditions are all based on the same degree (as opposed to the same elements) of inclusiveness, but it is by no means clear that such a supposition is justified. Continuing with our decimal analogy, might it not be suggested that whilst Christianity stemmed from experience of 2-3-4-5-6-7-8-9-10, Jainism was founded on a less extensive encounter with the divine (say 4-5-6-7-8-9-10)? It is, however, uncertain how we can compare and evaluate different religious traditions in such a way as to be able to comment on such claims. A definite danger of comparative religion is that by concentrating on establishing and exploring inter-religious likenesses, it may obscure the radical unlikeness of religious phenomena. It should be borne firmly in mind that such likenesses as may be established within comparative studies may not win religious phenomena a place within our understanding comparable to objects of more everyday concern. Statements found in the Old Testament, the Qur'an and the Vedas, for example, may, on occasion, be alike, but at the end of the day such things are often alike only, or chiefly, in so far as they display the same radical unlikeness in relation to the non-religious elements in our outlook.The analysis of radical unlikeness and ineffability which has been advanced might also suggest a way in which certain passages in religious writings could be understood, passages which at first sight can be seriously perplexing. If, for example, to return to the quotation given in the introductory section of this paper, we continue to think of accounts of the nature of Shiva as being attempts to describe some discrete, objective entity, then it is inevitable that either we will share the Puranic writer's puzzlement or that much of what we read about Shiva will appear as the muddled and extravagant thinking thrown up by an uncritical and over-fertile mythological imagination, consisting of little more than a hotch-potch of contradictory elements. But if we see such accounts as attempting to say something about everything, as symbols of near totality stemming from experiences which verge on the holistic, then what we read - with all its ambiguities - may become somewhat more meaningful. Thus W.D. O'Flaherty comments that Shiva “embodies all of life in all its detail at every minute” (Asceticism and Eroticism in the Mythology of Shiva, London 1973, p. 315). Similarly Alain Dani41ou sees Shiva, ultimately, in terms of his being "the supreme state of reality" beyond whom there is only "non-existence" (Hindu Polytheism, London 1964, p. 190).This analysis of ineffability and intelligibility seeks to introduce for debate a possible way of understanding the radical unlikeness which accounts of religious experience apparently attempt to speak about. It does not, however, claim to present an exhaustive treatment of the issues raised, on the contrary, I am conscious of many shortcomings and omissions. For instance, it remains to be seen under precisely what conditions something counts as being an elucidating likeness (presumably all experiences are, for example, temporal, yet temporality alone would not seem to offer a particularly elucidating comparison). Moreover, the degree to which appeal to likeness is allowed operation in actual accounts of religious experience needs to be explored. In addition, the notion of categorizing experiences according to the extent to which they approach a point of total inclusion requires careful clarification. To begin with, according to what criteria could we establish that one experience was more inclusive than another? However, such issues can only be mentioned here, any adequate consideration of them would require a separate paper.In conclusion, I would suggest that to use radical unlikeness and/or ineffability simply as devices by which to halt any process of investigation, proclaiming that the thing in question is not like anything and so is beyond all words, risks making unintelligible and placing beyond all further inquiry an important and extensive area of human experience. As William Alston put it, to label something ineffable in an unqualified way is to shirk the job of making explicit the ways in which it can be talked about. William P. Alston, “ineffability”, Philosophical Review 65 (1956), 522. It is surely more accurate to take ineffability as a “qualifier”I.T. Ramsey, Models and Mystery (Oxford 1964), p. 60. which “multiplies models without end”Ibid. than as an absolute which prevents the construction of any elucidating models. (shrink)

The problem of God today In some famously — some might say infamously — provocative letters from prison in June and July Dietrich Bonhoeffer reflects on the ...

This article is motivated by a reading of J.J. Abrams’ proceedings Shusterman’s Somaesthetics: From Hip Hop Philosophy to Politics and Performance Art. Of the diverse range of essays in the proceedings, I concentrate my attention primarily on those aspects of the texts that highlight Richard Shusterman’s practical somaesthetics, and in which their authors focus on the more personal aspects of Shusterman’s philosophical-artistic experimentation, as captured in The Adventures of the Man in Gold: Paths Between Art and Life, A Philosophical Tale. (...) Through references to Foucault’s notion of care of the self and the aesthetics of existence, the article demonstrates that the individual level of Shusterman’s practical somaesthetics is not separable from the social-ethical level. This is matched by the conclusion of the text, which points out that Shusterman’s practical somaesthetics overcomes the dichotomy of private and public in Richard Rorty’s pragmatism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Uncanonical Dante: The Divine Comedy And Islamic PhilosophyPaul A. CantorThe distorted notions of invisible things which Dante and hisrival Milton have idealized, are merely the mask and the mantlein which these great poets walk through eternity enveloped anddisguised. It is a difficult question to determine how far theywere conscious of the distinction which must have subsisted intheir minds between their own creeds and that of the people.Dante at (...) least appears to wish to mark the full extent of it byplacing Riphaeus, whom Virgil calls justissimus unus, inParadise, and observing a most heretical caprice in hisdistribution of rewards and punishments.—Percy Shelley, A Defence of PoetryIThe case of Dante provides an excellent opportunity to open up the question of the Western canon. In one sense, Dante is the perfect example of a canonical author. His name is one of the few certain to appear on anybody’s short list of the truly central authors in the Western literary tradition. But in another sense Dante can be regarded as uncanonical. In his own day he was widely suspected of being heretical in his religious views, 1 and a careful reading of his works does indeed raise serious doubts about his being the pillar of orthodoxy he is often taken to be today. 2 Out of this interplay between the canonical and the noncanonical Dante, I hope to show that the issue of the Western canon is more complicated than either its defenders or its attackers generally present it.In discussing the issue of the canon, it is important to sort out at the [End Page 138] beginning what we do and do not mean by the term. A canonical work may merely be a work that has been accepted into the literary canon, one that has become a touchstone in the reading and teaching of literature. But the term canonical can suggest something else, that the work is orthodox and somehow represents a central authoritative position in Western culture. The word canonical is so loaded with religious connotations that it is difficult to separate the relatively neutral first meaning of the term from the loaded second meaning. Dante is a case in point. When people refer to him as a canonical author, they usually do not simply mean that he is widely read and taught. Most discussions of Dante today treat him as representing an authoritative cultural moment in the Western tradition, as the supreme embodiment of the medieval mind. Viewed that way, Dante becomes an emblem of everything contemporary critics of the Western canon bitterly hate and reject. The reason they feel that they must attack authors like Dante and displace them from the center of literary study is that these authors have come to stand for orthodoxy and thus seem to enforce the hegemony of Western culture.Critics who wish to champion various forms of non-Western culture have a particular axe to grind with canonical authors like Dante. The contemporary debate over the Western canon seems to be premised on a sharp opposition between Western and non-Western cultures, as if they were complete and irreconcilable antitheses, and even wholly unrelated. One of the principal charges against the Western canon is that it is Eurocentric, that it remains confined within a narrow orbit of European ideas and beliefs, thus excluding all other views of the world. A corrolary of the idea of Eurocentrism is the concept of Orientalism, developed by Edward Said. 3 Said argues that throughout its history, the Occident has defined itself in opposition to the Orient, basing its elevated self-image on a debased vision of the cultural Other. In Said’s argument, the Occident views itself as rational as opposed to an irrational Orient, as emotionally disciplined in contrast to an emotionally uncontrolled Orient, and as masculine over against a feminine Orient.In medieval Europe the Orient was chiefly represented by the Muslim world, and one does not have to look far in medieval literature to find the kinds of orientalist stereotypes about which Said writes. The French Song of Roland contains excellent examples, but even the Divine Comedy seems to... (shrink)

Many adoptees face a number of challenges relating to separation from biological parents during the adoption process, including issues concerning identity, intimacy, attachment, and trust, as well as language and other cultural challenges. One common health challenge faced by adoptees involves lack of access to genetic-relative family health history. Lack of GRFHx represents a disadvantage due to a reduced capacity to identify diseases and recommend appropriate screening for conditions for which the adopted person may be at increased risk. In this (...) article, we draw out common features of traditionally understood “health disparities” in order to identify analogous features in the context of adoptees’ lack of GRFHx. (shrink)

From the 1660s onwards, France tried to establish itself as a leading maritime and colonial power. The first French East India Company allowed a decisive penetration into the Indian Ocean, while the foundation of the Rochefort arsenal was the starting point of a great shipbuilding effort. The archives of the State Secretariat of the French Navy, ports, and learned societies, as well as printed scholarly literature, testify to an increasing mobilisation around the health of the “gens de mer.” Most of (...) the actors involved in this reflection, whether doctors or surgeons, naval officers or engineers, scholars or inventors, agreed in associating seamen's diseases with the poor air quality prevailing within ships. The environment of seafarers was thus definitely regarded as harmful. However, the atmosphere of a ship was also seen through the possibility to reshape it and reduce its dangerousness, with adapted behaviours, careful maintenance, or technical solutions. This was crucial to ensure the circulation of human beings and goods across the French overseas empire, but also to defend it from the threats associated with the major conflicts of the second half of the 18th century. This article highlights how environments regarded as “pathogenic” were conceived and reshaped during the second half of the early modern period in France, using the example of naval hygiene. It examines the strategies designed and implemented to combat the “noxious” air of French ships, in particular through the regulations introduced since the end of the 17th century, and considers how this issue has stimulated the search for technological solutions. (shrink)

The rapid sequencing of entire genomes based in large measure on a DNA cloning procedure, the polymerase chain reaction (PCR), has opened new frontiers in the discovery process for novel therapeutic agents. DNA cloning is a basic tool in genomics and it has been used for over a decade. Drug discovery is currently focused on the identification of gene databases, gene arrays and protein arrays aimed at therapeutic modulation of disease-related genes—which require procedures that may involve cloning techniques. Currently, cloning (...) for pharmacologic products is most applicable in the preclinical area of drug discovery. For example, the identification of specific receptor subtypes occurred via cloning whereas traditional pharmacologic approaches that use agonists and antagonists may have failed to separate binding affinities. Successful therapeutic agents where cloning played vital role resulted in the development of synthetic insulin, growth hormone, erythropoiten and other tissue factors in blood products, Vaccines may be another successful application derived from cloning. Another area where cloning can make a significant impact upon human therapeutics is that this technique may provide a new source of cells for tissue engineering and transplantation. Stem cells, and in particular, embryonic stem cells can differentiate into other cell types such as hepatocytes and neurons to provide normal products for hepatic and neurological diseases. However, the use of cloning embryonic stem cells introduces important ethical, medical and legal issues which require that leaders in government, academic, and religious groups be fully educated in these applications. A close working relationship among these diverse groups is needed to respond wisely to the introduction of new therapeutic opportunities while at the same time providing protection for the individual and the public at large from unethical practises. (shrink)

Metacognitive training (MCT) was developed to promote awareness of reasoning biases among patients with schizophrenia. While MCT has been translated into 31 languages, most MCT studies were conducted in Europe, including newer evidence recommending an individualized approach of delivery. As reasoning biases covered in MCT are separable processes and are associated with different symptoms, testing the effect of selected MCT modules would help to develop a targeted and cost-effective intervention for specific symptoms and associated mechanisms. This study tested the efficacy (...) of a 4-session metacognitive training for delusions, MCTd (in Traditional Chinese with cultural adaptations, provided individually), as an adjunct to antipsychotics in reducing severity and conviction of delusions, jumping to conclusions bias and belief inflexibility. Forty-four patients with delusions were randomized into the MCTd or the wait-list control condition. Patients on wait-list received the same MCTd after four weeks of treatment as usual. Assessment interviews took place before and after the treatment, and at 4-week follow-up. There was an additional baseline assessment for the controls. Jumping to conclusions and belief flexibility were measured by the beads tasks and the Maudsley Assessment of Delusions Scale. Attendance rate of the MCTd was satisfactory (84.5%). Compared to treatment as usual, there was a greater reduction in psychotic symptoms, delusional severity and conviction following MCTd. There was a large treatment effect size in improvement in belief flexibility. Improvement in reaction to hypothetical contradiction predicted treatment effect in positive symptoms and delusions. Jumping to conclusions bias was reduced following MCTd, although the treatment effect was not significantly larger than TAU. Our results support the use of process-based interventions that target psychological mechanisms underlying specific psychotic symptoms as adjuncts to more conventional approach. (shrink)

When reading, orthographic information is extracted not only from the word the reader is looking at, but also from adjacent words in the parafovea. Here we examined, using the recently introduced OB1‐reader computational model, how orthographic information can be processed in parallel across multiple words and how orthographic information can be integrated across time and space. Although OB1‐reader is a model of text reading, here we used it to simulate single‐word recognition experiments in which parallel processing has been shown to (...) play a role by manipulating the surrounding context in flanker and priming paradigms. In flanker paradigms, observers recognize a central word flanked by other letter strings located left and right of the target and separated from the target by a space. The model successfully accounts for the finding that such flankers can aid word recognition when they contain bigrams of the target word, independent of where those flankers are in the visual field. In priming experiments, in which the target word is preceded by a masked prime, the model accounts for the finding that priming occurs independent of whether the prime and target word are in the same location or not. Crucial to these successes is the key role that spatial attention plays within OB1‐reader, as it allows the model to receive visual input from multiple locations in parallel, while limiting the kinds of errors that can potentially occur under such spatial pooling of orthographic information. (shrink)

Les confits parentaux aigus et séparations parentales ultraconflictuelles – souvent qualifiées de « déchirantes » – ont aujourd’hui massivement envahi les dispositifs de Protection de l’enfance. Cet article interroge les effets de tels contextes traumatogènes sur la vie psychique des enfants qui en sont victimes à partir de la pratique de psychologue clinicienne de l’auteure au sein d’un service éducatif en milieu ouvert, mais aussi de psychothérapeute psychanalytique en libéral. Au-delà du conflit de loyauté auquel sont confrontés ces enfants, l’auteure (...) analyse les traces de ces conflits parentaux aigus dans l’organisation somato-psychique de ces enfants, leur corps étant porteur de ces dynamiques conflictuelles. Des vignettes cliniques témoignent des effets de déchirure sur les enveloppes du Soi, appréhendés au travers de tableaux symptomatologiques spécifiques. Cette approche psychanalytique montre comment la « part déchirée du soi » chez ces enfants porte les traces des parents qui se déchirent sur leur dos. (shrink)