The language of self and nonself has had a prominent place inimmunology. This paper examines Frank Macfarlane Burnet's introductionof the language of selfhood into the science. The distinction betweenself and nonself was an integral part of Burnet's biological outlook– of his interest in the living organism in its totality, itsactivities, and interactions. We show the empirical and conceptualwork of the language of selfhood in the science. The relation betweenself and nonself tied into Burnet's ecological vision of host-parasiteinteraction. The idiom of (...) selfhood also enabled Burnet to organizeand unify a diversity of immune phenomena. Rather than approach thelanguage of self and nonself as a bluntly imposed metaphor, we focuson its endogenous origins and immanent uses in immunology. (shrink)

In this paper we address the issue of how to think about immunity. Many immunological writings suggest a straightforward option: the view that the immune system is primarily a system of defense, which naturally invites the talk of strong immunity and strong immune response. Despite their undisputable positive role in immunology, such metaphors can also pose a risk of establishing a narrow perspective, omitting from consideration phenomena that do not neatly fit those powerful metaphors. Building on this (...) analysis, we argue two things. First, we argue that the immune system is involved not only in defense. Second, by disentangling various possible meanings of ‘strength’ and ‘weakness’ in immunology, we also argue that such a construal of immunity generally contributes to the distortion of the overall picture of what the immune system is, what it does, and why it sometimes fails. Instead, we propose to understand the nature of the immune system in terms of contextuality, regulation, and trade-offs. We suggest that our approach provides lessons for a general understanding of the organizing principles of the immune system in health and disease. For all this to work, we discuss a wide range of immunological phenomena. (shrink)

In On Immunity: An Inoculation, essayist and author Eula Biss has given academics and clinicians interested in the public’s skepticism of vaccines, and of science skepticism more generally, a fresh look at what drives these phenomena. Despite public health’s continued success in maintaining high rates of coverage for vaccines across the United States, recent measles, mumps, and rubella outbreaks in the U.S. have harmed lives and indicate cracks in the vaccine uptake façade. From a public health perspective, it’s (...) all hands on deck to make sure vaccine coverage stays high. Biss’s outsiders’ view of these issues offers bioethicists, public health practitioners, and physicians much... (shrink)

In the postgenomic era, interactions between organism and environment are central in disciplines such as epigenetics, medical physiology, and immunology. Particularly in the more "applied" medical fields, an emphasis lies on interactions of the organism with other organisms, that is, other living things. There is, however, a growing amount of research investigating the impact of abiotic triggers on the immune system. While the distinction between biota and abiota features heavily in other contexts, its status is not explicit within immunology. Do (...) immunologists distinguish living from nonliving triggers? In this article, I will carve out whether and in which ways the biotic/abiotic distinction operates in immunology. I will look into responses to biotic and abiotic stressors in plant and invertebrate model species and ask how and why they are conceptually separated. I will trace the reasons by investigating the disciplinary situatedness of immune phenomena and the import of vertebrate immunology when conceptualizing immune responses in other model organisms. I will then investigate how the convergence of biotic and abiotic stress responses in plants and invertebrates adds to the recent philosophical programs advocating an ecological perspective on immune systems. (shrink)

Recently claims have been made for radical new insights in the field of invertebrate immunology that involve memory, specificity and/or maternal transfer of immunocompetence. For evidence these claims rely on phenomena, such as survival or reproductive capacity, observed at the level of the whole organism. The allure of these apparently revelatory hypotheses is that they are contrary to established views of innate immunity. They draw implicit analogy to adaptive responses in jawed vertebrates and the terminology used creates an (...) incomplete and misleading picture. We argue that the case for adaptive immunity in invertebrates based only on such phenomena is weak and flawed, as it can only be upheld if supported by descriptions of the underlying mechanisms. We caution against a reliance on this approach as a means of advancing this field—highlighting, as an example, some negative commercial implications of adopting this approach. BioEssays 29:1138–1146, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Despite the prevalence of post-colonial theory in the humanities and social sciences, why is it that the two main secular formations in the study of religion(s), as philosophy of religion and history of religions, continue to deploy very similar mechanisms that reconstitute past imperialisms such as the hegemony of theory as specifically Western and/or the division of labor between universal and particular knowledge formations? To answer this question this paper stages an oblique engagement between the seemingly divergent discourses: (i) philosophy (...) of religion, (ii) history of religion—more specifically the area specialism called South Asian religions, and (iii) post-colonial theory especially where these discourses intersect with the discipline of Indology and the representation of Indic phenomena. A different version of this engagement occurs in Hegel’s Lectures on the Philosophy of Religion (LPR). A post-colonial reading of the LPR reveals closer and often unacknowledged connections between the birth of these two disciplines. More importantly the LPR anticipates the auto-immunizing mechanism that underpins the continued lack of engagement between the various disciplines of contemporary religions. Ironically, this mechanism, it will be argued, is located in the very heart of the comparative enterprise itself. (shrink)

The ArgumentTwo research traditions in immunology, supposedly centered on the same issue of immune identification, have followed different theoretical goals and originated form competing phillosophical foundations. these may be labelled modernist and postmodernist, respectively, thereby applying cultural and philosophical categories to immunology in order to articulate potential scientific resonances with the broader culture. To accept that exercise and important caveat is imposed, namely, this translation is most appropriately discussed at the level of metaphor. In other words, I will structure my (...) treatment of these issues as expressed in the metaphorical language of the disipline, and thus the bulk of this discussion will focus on how the language and modeling of the science draws from the culture-at-large. Scientists seek images from their eveir everyday lives to describe phenomena that may be poorly articulated in their technical discourse; such is the utility and importance of metaphors generally, and thus it is not surprising that we might discern echoes of a postmodernist sentiment in the metaphors borrowed from post–World War II culture. I Will also discuss, to a more limited extent, how postmodernists have sought support for their own ideological arguments in immunology. This last topic server only to illustrate the bidirectionality of scientific discourse with the society in which it is embedded. (shrink)

Sydney Shoemaker, developing an idea of Wittgenstein’s, argues that we are immune to error through misidentification relative to the first-person pronoun. Although we might be liable to error when “I” (or its cognates) is used as an object, we are immune to error when “I” is used as a subject (as when one says, “I have a toothache”). Shoemaker claims that the relationship between “I” as-subject and the mental states of which it is introspectively aware is tautological: when, say, we (...) judge that “I feel pain,” we are tautologically aware that feels pain is instantiated and that it is instantiated in oneself. Moreover, he contends that this relationship holds not just for bodily sensations, but also for the sense of agency and for visual perception. But we deny that this relationship is tautological; instead, we treat Shoemaker’s principle (IEM) as a hypothesis. We then proceed to show that certain pathological states and experimentally-induced illusions can be adduced to show that IEM describes not a necessary relationship but a contingent relationship, one that sometimes fails to obtain. That we are not immune to error in the way Shoemaker describes has grave consequences for many aspects of his ideas concerning the first-person perspective. In the course of arguing that these empirical phenomena count against IEM, we also show that not only can the content of conscious experience be misrepresented, so too can the subject: that is, not only can the what of conscious experience be misrepresented, so too can the who. (shrink)

Study of the multiplicity of interactions between invertebrate hosts and their parasites helps to define the aspects of the host immune systems that have ecological and evolutionary significance. Such study, however, reveals how much is yet unknown. For instance, the costs of mounting an immune response, the nature of the long-lasting protection sometimes attained, and the high degree of specificity observed in certain hosts are phenomena that still await full explanation. An additional puzzle is the high degree of specificity (...) achieved in light of the apparent low degree of specificity in the recognition and effector mechanisms of insect immune systems. Furthermore, while protective immunity is typically associated with vertebrate adaptive immune systems, invertebrates may have analogous capacities, whose nature is still largely unknown. This review will illustrate how the traditional host-centred view of immune defence can be usefully extended by taking account of parasite immune evasion strategies and the variation that such strategies create in the observed outcomes of infection. BioEssays 27:1026–1034, 2005. © 2005 Wiley Peiodicals, Inc. (shrink)

Sydney Shoemaker argues that a certain class of self-ascriptions is immune to error through misidentification relative to the first-person pronouns. In their “Self-Consciousness and Immunity,” Timothy Lane and Caleb Liang question Shoemaker’s view. Lang and Liang present a clinical case and an experiment and argue that they are counterexamples to Shoemaker’s view. This paper is a response to Lane and Liang’s challenge. I identify the desiderata that a counterexample to Shoemaker’s view must meet and show that somatoparaphrenia and the (...) Body Swap Illusion fail to meet those desiderata. Thus, despite being puzzling phenomena, somatoparaphrenia and the Body Swap Illusion are not counterexamples to Shoemaker’s view. (shrink)

Upshot: The cognitive paradigm organizes immune phenomena with an eye towards understanding the immune system as a perceptive faculty, where examination of the basic regulation of unstimulated immune activity becomes the primary investigative focus. While a fecund research program organized around the hypothesized “autonomous network theory” has yielded important insight into the “conservative physiology of the immune system,” the theoretical basis for these studies offers little more than one set of metaphors (arranged around “cognition”) challenging another (“selfhood”). However, breaking (...) the theoretical hold of protecting the immune self as the focus of immunology is no mean feat in terms of shifting research interest towards a key, but neglected aspect of immunity. (shrink)

Self‐consciousness is a topic located at the intersection of a range of different philosophical concerns. One set of concerns is metaphysical. Another is epistemological. When discussing the phenomenon of consciousness in general, philosophers generally think it possible to give an account of consciousness that is independent of how one understands the objects, properties, and events of which one is conscious. Self‐consciousness is important because of the role it plays in the cognitive economy. Self‐consciousness can be understood either in terms of (...) direct awareness of the self or in terms of propositional awareness. Self‐conscious thoughts can be based on a range of different sources of information. Some of these sources can provide information either about the self or about other people. Some influential accounts of self‐consciousness, such as those of Shoemaker (1963, 1968) and Evans (1982), have attributed a fundamental role to the phenomenon of immunity to error through misidentification. (shrink)

The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for 60 years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that (...) another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity. (shrink)

An allergy is commonly understood to be an overreaction of the immune system to harmless substances that are misrecognised as foreign. This concept of allergy as an abnormal, misdirected immune response—a biological fault—stems from the idea that the immune system is an inherently defensive operation designed to protect the individual through an innate capacity to discriminate between the benign and toxic, or self and nonself. However, this definition of allergy represents a radical departure from its original formulation. Literally meaning ‘altered (...) reactivity’, the term was coined in 1906 by Austrian paediatrician Clemens von Pirquet, to describe the fundamentally mutable nature of the immune response.This paper argues that the conventional interpretation of allergy-as-pathology derives from specific concepts of ‘organism’, ‘response’, and ‘normal’ immune function that have—for over a century—governed the perception and study of immune phenomena within immunology. Through an examination of Louis Pasteur’s conceptualisation of the host body/microorganism relationship, I argue that immunology is founded on a view of the organism as a discrete, autonomous entity, and on a concomitant notion of the immune response as essentially reactive. Revisiting the concept of ‘altered reactivity’, this paper points to the fact that allergy was initially posited as a general theory of immune responsiveness and, importantly, one that poses a significant challenge to orthodox notions of immunopathology. It suggests that Pirquet’s unique view of immune responsiveness presents an account of organismic or biological identity that encapsulates, rather than reduces, its ecological complexity. (shrink)

As an empirical example of introspective conditions in which the normal sense of self is disrupted, the delusion of thought insertion is of special interest to philosophers investigating the epistemic and phenomenological structures of introspection. A common strategy is to use immunity to error through misidentification as a tool with which to pick apart the implications of thought insertion for our understanding of the faculty of introspection. In this paper I turn that strategy on its head: I draw on (...) our understanding of introspection and of thought insertion to make two correctives to the literature on immunity to error through misidentification. The first is the identification of a formal distinction between two phenomena sometimes conflated under the rubric of misidentification errors. The second is a weakening of the presumed significance of claims to immunity to error through misidentification. With these tightenings to the notion of immunity to error through misidentification in hand, we will be in a better position to turn again to questions about the epistemic and phenomenological nature of introspection. (shrink)

Converging data from different disciplines are showing the role of classical conditioning processes in the elaboration of human and animal behavior to be larger than previously supposed. Restricted views of classically conditioned responses as merely secretory, reflexive, or emotional are giving way to a broader conception that includes problem-solving, and other rule-governed behavior thought to be the exclusive province of either operant conditiońing or cognitive psychology. These new views have been accompanied by changes in the way conditioning is conducted and (...) evaluated. Data from a number of seemingly unrelated phenomena such as relapse to drug abuse by postaddicts, the placebo effect, and the immune response appear to involve classical conditioning processes. Classical conditioning, moreover, has been found to occur in simpler and simpler organisms and recently even demonstrated in brain slices and in utero. This target article will integrate the several research areas that have used the classical conditioning process as an explanatory model; it will challenge teleological interpretations of the classically conditioned CR and offer some basic principles for testing conditioning in diverse areas. (shrink)

Functionalism about mental phenomena must account for their multiple realizability. According to standard doctrine, this can be achieved by allowing our folk theory's realization formula to be multiply satisfied by distinct physical properties. If at all, uniqueness can then be restored by suitable relativization to populations or worlds. Recent arguments suggest that this is a dead end. Here the attempt is made to devise a novel type of functionalism that accounts for multiple realizability but rejects the standard doctrine and (...) thus proves immune to those arguments. The distinctive feature of this novel type of functionalism is its use of plural quantification in ramsification, which allows it to retain uniqueness of satisfaction despite multiple realizability while respecting naturalness requirements on physical properties. (shrink)

A theory of understanding -- Truth's role in understanding -- Critique of justificationist and evidential accounts -- Do pragmatist views avoid this critique? -- A realistic account -- How evidence and truth are related -- Three grades of involvement of truth in theories of understanding -- Anchoring -- Next steps -- Reference and reasons -- The main thesis and its location -- Exposition and four argument-types -- Significance and consequences of the main thesis -- The first person as a case (...) study -- Fully self-conscious thought -- Immunity to error through misidentification relative to the first person -- Can a use of the first-person concept fail to refer? -- Some conceptual roles are distinctive but not fundamental -- Implicit conceptions -- Implicit conceptions : motivation and examples -- Deflationary readings rejected -- The phenomenon of new principles -- Explanation by implicit conceptions -- Rationalist aspects -- Consequences : rationality, justification, understanding -- Transitional -- Applications to mental concepts -- Conceiving of conscious states -- Understanding and identity in other cases -- Constraints on legitimate explanations in terms of identity -- Why is the subjective case different? -- Attractions of the interlocking account -- Tacit knowledge, and externalism about the internal -- Is this the myth of the given? -- Knowledge of others' conscious states -- Communicability : between Frege and Wittgenstein -- Conclusions and significance -- 'Another I' : representing perception and action -- The core rule -- Modal status and its significance -- Comparisons -- The possession-condition and some empirical phenomena -- The model generalized -- Wider issues -- Mental action -- The distinctive features of action-awareness -- The nature and range of mental actions -- The principal hypothesis and its grounds -- The principal hypothesis : distinctions and consequences -- How do we know about our own mental actions? -- Concepts of mental actions and their epistemological significance -- Is this account open to the same objections as perceptual models of introspection? -- Characterizing and unifying schizophrenic experience -- The first person in the self-ascription of action -- Rational agency and action-awareness -- Representing thoughts -- The puzzle -- A proposal -- How the solution treats the constraints that generate the puzzle -- Relation to single-level treatments -- An application : reconciling externalism with distinctive self-knowledge. (shrink)

For a long time, several natural phenomena have been considered unproblematically selection processes in the same sense of “selection.” In our target article we dealt with three of these phenomena: gene-based selection in biological evolution, the reaction of the immune system to antigens, and operant learning. We characterize selection in terms of three processes (variation, replication, and environmental interaction) resulting in the evolution of lineages via differential replication. Our commentators were largely supportive with respect to variation and environmental (...) interaction but critical with respect to replication, in particular its appeal to information. With some reservations, our commentators think that our general analysis of selection may fit gene-based selection in biological evolution and the reaction of the immune system but not operant learning. If nothing else, this article shows that the notion of selection is not as straightforward as it may seem. (shrink)

In his insightful review, Eugene V. Koonin discusses various aspects of CRISPR-Cas systems with a strong focus on their qualities as "adaptive immune systems". The CRISPR-Cas system is most famous for its application as a gene-editing tool. Koonin provides a deeper insight into its biological function in bacteria, which is to immunize the cell against parasite DNA. I shall comment on one issue discussed in the text, in two steps. First, I shall elaborate on CRISPR-Cas systems and their supposed Lamarckian (...) character. Criteria for calling biological phenomena genuinely Lamarckian will be narrowed down and then applied to the CRISPR-Cas system, considering interference-driven spacer acquisition as an instantiation of a truly Lamarckian paradigm. Second, I shall consider whether Lamarckian and "canonical" instances of inheritance are a case of theoretical pluralism, being two non-reducible, yet interconnected paradigms. (shrink)

In this paper, I try to develop an account of functions which might be of use to a biologist engaged in classifying and explaining natural phenomena. The most pressing difficulty facing such an account is the need to reconcile the normativity of function statements with their explanatory force. I consider two familiar accounts of function statements, offered by Andrew Woodfield and Larry Wright . I examine both accounts in search of the strongest possible formulation of each type of theory. (...) I fail to find a formulation of the ACT which is completely immune from counterexamples, but I do find a satisfactory formulation of the HT. In particular, I argue that the HT should incorporate a point central to the ACT that functions involve a means/end relationship between two devices. I then consider functional explanations: I argue that an ACT which holds that function statements are intrinsically explanatory cannot offer a satisfactory account. The account offered by Woodfield, who rejects this assumption, is adequate, though less attractive than the account suggested by the HT. I conclude by considering how the HT can account for functional norms. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.1 (2003) 125-126 [Access article in PDF] Sextus Empiricus. Against the Grammarians (Adversos Mathematicos I). Introduction, Commentary, and Translation by D. L. Blank. Oxford: Clarendon Press, 1998. Pp. lvi + 436. Cloth, $105.00. Sesto Empirico. Contro gli astrologi. Introduction, Commentary, and Translation by Emidio Spinelli. Naples: Bibliopolis, 2000. Pp. 230. Paper, L. 70.000. No historian of philosophy should be retailing the old canards (...) that the Hellenistic philosopher Sextus Empiricus was silly, wholly confused, or merely a compiler and not a philosopher in his own right. These translations and commentaries, along with the recent work of Richard Bett, James Hankinson, and others, should bury those notions forever.Against the Grammarians is the first and Against the Astrologers is the fifth volume of Sextus's six-volume Against the Teachers of the technai or professional arts and sciences (grammar, rhetoric, geometry, arithmetic, astrology, and music). Sextus is not against all forms of the study of these matters; in fact, one of the skeptic's "rules for living" is that he will engage in an art (techne) to make a living (Outlines of Pyrrhonism, I.24). But he is against the claims of each of them to special technical expertise. He prefers the unpretentious experience of everyday life—living by the phenomena; non-expert, practical forms of grammar, astronomy, music—to fancy theories about the nature of things.Against the Grammarians is Sextus's critique of the interpreters of poetry and prose—today's English professors and historians. Philosophers will be amused by his deconstruction of various sorts of lit crit arrogance and rashness that are still with us. Regrettably, some of us are not immune from the same critiques.Against the Astrologers is Sextus's critique of the Chaldean soothsayers. He is not against the observation of celestial phenomena for agricultural or navigational purposes. His critiques of the astrologers for lack of empirical evidence and promotion of superstition make him sound like a proto-scientist.One originality of Sextus's work was his combination of a dogmatic Epicurean critique of the grammatologists and astrologers with a skeptical aporetic critique. Precisely because he does not hesitate to make use of the arguments of others, some interpreters have decided that Sextus was unoriginal and derivative. But Blank and Spinelli both show that he recombines these arguments in ways that no one else had done. That is one of the ways of being original in philosophy. The upshot is that he is our earliest source of quite a number of critiques of grammarians and astrologers.The use of dogmatic arguments raises the problem of whether Sextus engages in so-called "negative dogmatism" in these volumes. Right at the beginning of Against the Astrologers, Sextus accuses them of violating "right reason." What right does a skeptic have to invoke such a standard? Some have felt that at this stage Sextus was a dogmatic skeptic, invoking one set of truths to tear down another. But that is not necessary. Blank and Spinelli explain this well with a combination of points. One, we can see the dogmatic and Epicurean attacks as clearing the ground for the following skeptical equipollence of arguments. Two, we can follow Jonathan Barnes in assuming that each claim that something has been demolished assumes the counterargument that it has been proven, so that the implied upshot is equipollence. Three, "right reason" can be the sort of unpretentious practical reasoning and living in accord with the appearances that the skeptics often claimed to live by.Spinelli and Blank provide many useful improvements over the previous English translations of these texts by Bury and the Italian translations by Russo. Blank rightly relies on Spinelli's 1995 translation and commentary on Sextus's Against the Ethicists and Spinelli rightly relies on Blank for a number of points. Spinelli supplies the Greek on facing pages of the translation; Blank does not. Spinelli also supplies five Greek zodiac charts and a beautiful print of a fifteenth-century zodiac.Neither Blank nor Spinelli unduly lionizes Sextus. They admit that... (shrink)

The COVID-19 pandemic invites a question about how long-standing narratives of alterity and current narratives of disease are entwined and re-enacted in the diagnosis of COVID-19. In this commentary, we discuss two related phenomena that, we argue, should be taken into account in answering this question. First, we address the diffusion of pseudoscientific accounts of minorities’ immunity to COVID-19. While apparently praising minorities’ biological resistance, such accounts rhetorically introduce a distinction between “Us” and “Them,” and in so doing (...) produce new and re-enact old narratives of alterity. Second, these unsubstantiated narratives thrive on fake news and scarcity of data. The second part of this commentary thus surveys the methods through which the COVID-19 test is administered in various countries. We argue that techniques used for data collection have a major role in producing COVID-19 data that render contagion rates among migrants and other minorities invisible. In the conclusion, we provide two recommendations about how COVID-19 data can instead potentially work towards inclusion. (shrink)

In this paper I present an overview of my research in the philosophy of language in mind over more than thirty years, from my early work on speech act theory to my current work on mental files. The unifying theme is context-dependence,both in language and thought. I distinguish several varieties of context-dependence and, along the way, provide tentative accounts of various phenomena: performative utterances, indexicals, modulation (metonymy and loose talk, free enrichment), de se thought, the content of experiential states, (...) and immunity to error through misidentification. (shrink)

If preference-based freedom rankings are based on all-things-considered preferences, they risk judging phenomena of adaptive preferences as freedom enhancing. As a remedy, it has been suggested to base preference-based freedom rankings on reasonable preferences. But this approach is also problematic. This article argues that the quest for a remedy is unnecessary. All-things-considered preferences retain information on whether the availability of an option contributes to the value that freedom has for a person’s self-expression. If preference-based freedom rankings use all-things-considered preferences (...) to evaluate whether an option contributes to a person’s self-expression, they are immune to the problem posed by adaptive preferences. (shrink)

ABSTRACT I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments. INTRODUCTION In contrast to the classic model of randomized-control trials, often with a large number of (...) subjects enrolled, precision medicine attempts to optimize therapeutic outcomes by focusing on the individual.[i] A recent publication highlights the strengths and weakness of both traditional evidence-based medicine and precision medicine.[ii] Plus, it outlines a tension in the shift from evidence-based medicine’s inductive reasoning style (the collection of data to postulate general theories) to precision medicine’s abductive reasoning style (the generation of an idea from the limited data available).[iii] The paper’s main example is the application of precision medicine for the treatment of cancer.[iv] I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. As the name suggests, brain-computer interfaces are a significant advancement in neurotechnology that directly connects someone’s brain to external or implanted devices.[v] Among the various kinds of brain-computer interfaces, adaptive deep brain stimulation devices require numerous personalized adjustments to their settings during the implantation and computation stages in order to provide adequate relief to patients with treatment-resistant disorders. What makes these devices unique is how adaptive deep brain stimulation integrates a sensory component to initiate the stimulation. While not commonly at the level of sophistication as self-supervising or generative large language models,[vi] they currently allow for a semi-autonomous form of neuromodulation. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments.[vii] ANALYSIS I. The State of Precision Medicine in Oncology and the Epistemological Shift While a thorough overview of precision medicine for the treatment of cancer is beyond the scope of this article, its practice can be roughly summarized as identifying clinically significant characteristics a patient possesses (e.g., genetic traits) to land on a specialized treatment option that, theoretically, should benefit the patient the most.[viii] However, in such a practice of stratification patients fall into smaller and smaller populations and the quality of evidence that can be applied to anyone outside these decreases in turn.[ix] As inductive logic helps to articulate, the greater the number of patients that respond to a particular therapy the higher the probability of its efficacy. By straying from this logical framework, precision medicine opens the treatment of cancer to more uncertainty about the validity of these approaches to the resulting disease subcategories.[x] Thus, while contemporary medical practices explicitly describe some treatments as “personalized”, they ought not be viewed as inherently better founded than other therapies.[xi] A relevant contemporary case of precision medicine out of Norway focuses on the care of a patient with cancer between the ventricles of the heart and esophagus, which had failed to respond to the standard regimen of therapies over four years.[xii] In a last-ditch effort, the patient elected to pay out-of-pocket for an experimental immunotherapy (nivolumab) at a private hospital. He experienced marked improvements and a reduction in the size of the tumor. Understandably, the patient tried to pursue further rounds of nivolumab at a public hospital. However, the hospital initially declined to pay for it given the “lack of evidence from randomised clinical trials for this drug relating to this [patient’s] condition.”[xiii] In rebuttal to this claim, the patient countered that he was actually similar to a subpopulation of patients who responded in “open‐label, single arm, phase 2 studies on another immune therapy drug” (pembrolizumab).[xiv] Given this interpretation of the prior studies and the patient’s response, further rounds of nivolumab were approved. Had the patient not had improvements in the tumor’s size following a round of nivolumab, then pembrolizumab’s prior empirical evidence in isolation would have been insufficient, inductively speaking, to justify his continued use of nivolumab.[xv] The case demonstrates a shift in reasoning from the traditional induction to abduction. The phenomenon of ‘cancer improvement’ is considered causally linked to nivolumab and its underlying physiological mechanisms.[xvi] However, “the weakness of abductions is that there may always be some other better, unknown explanation for an effect. The patient may for example belong to a special subgroup that spontaneously improves, or the change may be a placebo effect. This does not mean, however, that abductive inferences cannot be strong or reasonable, in the sense that they can make a conclusion probable.”[xvii] To demonstrate the limitations of relying on the abductive standard in isolation, commentators have pointed out that side effects in precision medicine are hard to rule out as being related to the initial intervention itself unless trends from a group of patients are taken into consideration.[xviii] As artificial intelligence (AI) assists the development of precision medicine for oncology, this uncertainty ought to be taken into consideration. The implementation of AI has been crucial to the development of precision medicine by providing a way to combine large patient datasets or a single patient with a large number of unique variables with machine learning to recommend matches based on statistics and probability of success upon which practitioners can base medical recommendations.[xix] The AI is usually not establishing a causal relationship[xx] – it is predicting. So, as AI bleeds into medical devices, like brain-computer interfaces, the same cautions about using abductive reasoning alone should be carried over. II. Responsive Neurostimulation, AI, and Personalized Medicine Like precision medicine in cancer treatment, computer-brain interface technology similarly focuses on the individual patient through personalized settings. In order to properly expose the intersection of AI, precision medicine, abductive reasoning, and implantable neurotechnologies, the descriptions of adaptive deep brain stimulation systems need to deepen.[xxi] As a broad summary of adaptive deep brain stimulation, to provide a patient with the therapeutic stimulation, a neural signal, typically referred to as a local field potential,[xxii] must first be detected and then interpreted by the device. The main adaptive deep brain stimulation device with premarket approval, the NeuroPace Responsive Neurostimulation system, is used to treat epilepsy by detecting and storing “programmer-defined phenomena.”[xxiii] Providers can optimize the detection settings of the device to align with the patient’s unique electrographic seizures as well as personalize the reacting stimulation’s parameters.[xxiv] The provider adjusts the technology based on trial and error. One day machine learning algorithms will be able to regularly aid this process in myriad ways, such as by identifying the specific stimulation settings a patient may respond to ahead of time based on their electrophysiological signatures.[xxv] Either way, with AI or programmers, adaptive neurostimulation technologies are individualized and therefore operate in line with precision medicine rather than standard treatments based on large clinical trials. Contemporary neurostimulation devices are not usually sophisticated enough to be prominent in AI discussions where the topics of neural networks, deep learning, generative models, and self-attention dominate the conversation. However, implantable high-density electrocorticography arrays (a much more sensitive version than adaptive deep brain stimulation systems use) have been used in combination with neural networks to help patients with neurologic deficits from a prior stroke “speak” through a virtual avatar.[xxvi] In some experimental situations, algorithms are optimizing stimulation parameters with increasing levels of independence.[xxvii] An example of neurostimulation that is analogous to the use of nivolumab in Norway surrounds a patient in the United States who was experiencing both treatment-resistant OCD and temporal lobe epilepsy.[xxviii]Given the refractory nature of her epilepsy, implantation of an adaptive deep brain stimulation system was indicated. As a form of experimental therapy, her treatment-resistant OCD was also indicated for the off-label use of an adaptive deep brain stimulation set-up. Another deep brain stimulation lead, other than the one implanted for epilepsy, was placed in the patient’s right nucleus accumbens and ventral pallidum region given the correlation these nuclei had with OCD symptoms in prior research. Following this, the patient underwent “1) ambulatory, patient-initiated magnet-swipe storage of data during moments of obsessive thoughts; (2) lab-based, naturalistic provocation of OCD-related distress (naturalistic provocation task); and (3) lab-based, VR [virtual reality] provocation of OCD-related distress (VR provocation task).”[xxix] Such signals were used to identify when to deliver the therapeutic stimulation in order to counter the OCD symptoms. Thankfully, following the procedure and calibration the patient exhibited marked improvements in their OCD symptoms and recently shared her results publicly.[xxx] In both cases, there is a similar level of abductive justification for the efficacy of the delivered therapy. In the case study in which the patient was treated with adaptive deep brain stimulation, they at least had their neural activity tested in various settings to determine the optimum parameters for treatment to avoid them being based on guesswork. Additionally, the adaptive deep brain stimulation lead was already placed before the calibration trials were conducted, meaning that the patient had already taken on the bulk of the procedural risk before the efficacy could be determined. Such an efficacy test could have been replicated in the first patient’s cancer treatment, had it been biopsied and tested against the remaining immunotherapies in vitro. Yet, in the case of cancer with few options, one previous dose of a drug that appeared to work on the patient may justify further doses. However, as the Norwegian case presents, corroboration with known responses to a similar drug (from a clinical trial) could be helpful to validate the treatment strategy. (It should be noted that both patients were resigned to these last resort options regardless of the efficacy of treatment.) There are some elements of inductive logic seen with adaptive deep brain stimulation research in general. For example, abductively the focus could be that patient X’s stimulation parameters are different from patient Y’s and patient Z’s. In contrast, when grouped as subjects who obtained personalized stimulation, patients X, Y, and Z demonstrate an inductive aspect to this approach’s safety and/or efficacy. The OCD case holds plenty of abductive characteristics in line with precision medicine’s approach to treating cancer and as more individuals try the method, there will be additional data. With the gradual integration of AI into brain-computer interfaces in the name of efficacy, this reliance on abduction will continue, if not grow, over time. Moving forward, if a responsive deep brain stimulation treatment is novel and individualized (like the dose of nivolumab) and there is some other suggestion of efficacy (like clinical similarities to other patients in the literature), then it may justify insurance coverage for the investigative intervention, absent other unrelated reasons to deny it. III. Ethical Implications and Next Steps While AI’s use in oncology and neurology is not yet as prominent as its use in other fields (e.g., radiology), it appears to be on the horizon for both.[xxxi] AI can be found in both the functioning of the neurotechnologies as well as the implementation of precision medicine. The increasing use of AI may serve to further individualize both oncologic and neurological therapies. Given these implications and the handful of publications cited in this article, it is important to have a nuanced evaluation of how these treatments, which heavily rely on abductive justification, ought to be managed. The just use an abductive approach may be difficult as AI infused precision medicine is further pursued. At baseline, such technology relies on a level of advanced technology literacy among the general public and could exclude populations who lack access to basic technological infrastructure or know-how from participation.[xxxii] Even among nations with adequate infrastructure, as more patients seek out implantable neurotechnologies, which require robust healthcare resources, the market will favor patient populations that can afford this complex care.[xxxiii] If patients already have the means to pay for an initial dose/use of a precision medicine product out of pocket, should insurance providers be required to cover subsequent treatments?[xxxiv] That is, if a first dose of a cancer drug or a deep brain stimulator over its initial battery life is successful, patients may feel justified in having the costs of further treatments covered. The Norwegian patient’s experience implies there is a precedent for the idea that some public insurance companies ought to cover successful cancer therapies, however, insurance companies may not all see themselves as obligated to cover neurotechnologies that rely on personalized settings or that are based on precision/abductive research more than on clinical trials. CONCLUSION The fact that the cases outlined above rely on abductive style of reasoning implies that there may not be as strong a justification for coverage by insurance, as they are both experimental and individualized, when compared to the more traditional large clinical trials in which groups have the same or a standardized protocol (settings/doses). If a study is examining the efficacy of a treatment with a large cohort of patients or with different experimental groups/phases, insurance companies may conclude that the resulting symptom improvements are more likely to be coming from the devices themselves. A preference for inductive justification may take priority when ruling in favor of funding someone’s continued use of an implantable neurostimulator. There are further nuances to this discussion surrounding the classifications of these interventions as research versus clinical care that warrant future exploration, since such a distinction is more of a scale[xxxv] than binary and could have significant impacts on the “right-to-try” approach to experimental therapies in the United States.[xxxvi] Namely, given the inherent limitations of conducting large cohort trials for deep brain stimulation interventions on patients with neuropsychiatric disorders, surgically innovative frameworks that blend abductive and inductive methodologies, like with sham stimulation phases, have traditionally been used.[xxxvii] Similarly, for adaptive brain-computer interface systems, if there are no large clinical trials and instead only publications that demonstrate that something similar worked for someone else, then, in addition to the evidence that the first treatment/dose worked for the patient in question, the balance of reasoning would be valid and arguably justify insurance coverage. As precision approaches to neurotechnology become more common, frameworks for evaluating efficacy will be crucial both for insurance coverage and for clinical decision making. ACKNOWLEDGEMENT This article was originally written as an assignment for Dr. Francis Shen’s “Bioethics & AI” course at Harvard’s Center for Bioethics. I would like to thank Dr. Shen for his comments as well as my colleagues in the Lázaro-Muñoz Lab for their feedback. - [i] Jonathan Kimmelman and Ian Tannock, “The Paradox of Precision Medicine,” Nature Reviews. Clinical Oncology 15, no. 6 (June 2018): 341–42, https://doi.org/10.1038/s41571-018-0016-0. [ii] Henrik Vogt and Bjørn Hofmann, “How Precision Medicine Changes Medical Epistemology: A Formative Case from Norway,” Journal of Evaluation in Clinical Practice 28, no. 6 (December 2022): 1205–12, https://doi.org/10.1111/jep.13649. [iii] David Barrett and Ahtisham Younas, “Induction, Deduction and Abduction,” Evidence-Based Nursing 27, no. 1 (January 1, 2024): 6–7, https://doi.org/10.1136/ebnurs-2023-103873. [iv] Vogt and Hofmann, “How Precision Medicine Changes Medical Epistemology,” 1208. [v] Wireko Andrew Awuah et al., “Bridging Minds and Machines: The Recent Advances of Brain-Computer Interfaces in Neurological and Neurosurgical Applications,” World Neurosurgery, May 22, 2024, S1878-8750(24)00867-2, https://doi.org/10.1016/j.wneu.2024.05.104. [vi] Mark Riedl, “A Very Gentle Introduction to Large Language Models without the Hype,” Medium (blog), May 25, 2023, https://mark-riedl.medium.com/a-very-gentle-introduction-to-large-language-models-without-the-hype-5 f67941fa59e. [vii] David E. Burdette and Barbara E. Swartz, “Chapter 4 - Responsive Neurostimulation,” in Neurostimulation for Epilepsy, ed. Vikram R. Rao (Academic Press, 2023), 97–132, https://doi.org/10.1016/B978-0-323-91702-5.00002-5. [viii] Kimmelman and Tannock, 2018. [ix] Kimmelman and Tannock, 2018. [x] Simon Lohse, “Mapping Uncertainty in Precision Medicine: A Systematic Scoping Review,” Journal of Evaluation in Clinical Practice 29, no. 3 (April 2023): 554–64, https://doi.org/10.1111/jep.13789. [xi] Kimmelman and Tannock, “The Paradox of Precision Medicine.” [xii] Vogt and Hofmann, 1206. [xiii] Vogt and Hofmann, 1206. [xiv] Vogt and Hofmann, 1206. [xv] Vogt and Hofmann, 1207. [xvi] Vogt and Hofmann, 1207. [xvii] Vogt and Hofmann, 1207. [xviii] Vogt and Hofmann, 1210. [xix] Mehar Sahu et al., “Chapter Three - Artificial Intelligence and Machine Learning in Precision Medicine: A Paradigm Shift in Big Data Analysis,” in Progress in Molecular Biology and Translational Science, ed. David B. Teplow, vol. 190, 1 vols., Precision Medicine (Academic Press, 2022), 57–100, https://doi.org/10.1016/bs.pmbts.2022.03.002. [xx] Stefan Feuerriegel et al., “Causal Machine Learning for Predicting Treatment Outcomes,” Nature Medicine 30, no. 4 (April 2024): 958–68, https://doi.org/10.1038/s41591-024-02902-1. [xxi] Sunderland Baker et al., “Ethical Considerations in Closed Loop Deep Brain Stimulation,” Deep Brain Stimulation 3 (October 1, 2023): 8–15, https://doi.org/10.1016/j.jdbs.2023.11.001. [xxii] David Haslacher et al., “AI for Brain-Computer Interfaces,” 2024, 7, https://doi.org/10.1016/bs.dnb.2024.02.003. [xxiii] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 103–4; “Premarket Approval (PMA),” https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P100026. [xxiv] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 104. [xxv] Burdette and Swartz, 126. [xxvi] Sean L. Metzger et al., “A High-Performance Neuroprosthesis for Speech Decoding and Avatar Control,” Nature 620, no. 7976 (August 2023): 1037–46, https://doi.org/10.1038/s41586-023-06443-4. [xxvii] Hao Fang and Yuxiao Yang, “Predictive Neuromodulation of Cingulo-Frontal Neural Dynamics in Major Depressive Disorder Using a Brain-Computer Interface System: A Simulation Study,” Frontiers in Computational Neuroscience 17 (March 6, 2023), https://doi.org/10.3389/fncom.2023.1119685; Mahsa Malekmohammadi et al., “Kinematic Adaptive Deep Brain Stimulation for Resting Tremor in Parkinson’s Disease,” Movement Disorders 31, no. 3 (2016): 426–28, https://doi.org/10.1002/mds.26482. [xxviii] Young-Hoon Nho et al., “Responsive Deep Brain Stimulation Guided by Ventral Striatal Electrophysiology of Obsession Durably Ameliorates Compulsion,” Neuron 0, no. 0 (October 20, 2023), https://doi.org/10.1016/j.neuron.2023.09.034. [xxix] Nho et al. [xxx] Nho et al.; Erik Robinson, “Brain Implant at OHSU Successfully Controls Both Seizures and OCD,” OHSU News, accessed March 3, 2024, https://news.ohsu.edu/2023/10/25/brain-implant-at-ohsu-successfully-controls-both-seizures-and-ocd. [xxxi] Awuah et al., “Bridging Minds and Machines”; Haslacher et al., “AI for Brain-Computer Interfaces.” [xxxii] Awuah et al., “Bridging Minds and Machines.” [xxxiii] Sara Green, Barbara Prainsack, and Maya Sabatello, “The Roots of (in)Equity in Precision Medicine: Gaps in the Discourse,” Personalized Medicine 21, no. 1 (January 2024): 5–9, https://doi.org/10.2217/pme-2023-0097. [xxxiv] Green, Prainsack, and Sabatello, 7. [xxxv] Robyn Bluhm and Kirstin Borgerson, “An Epistemic Argument for Research-Practice Integration in Medicine,” The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine 43, no. 4 (July 9, 2018): 469–84, https://doi.org/10.1093/jmp/jhy009. [xxxvi] Vijay Mahant, “‘Right-to-Try’ Experimental Drugs: An Overview,” Journal of Translational Medicine 18 (June 23, 2020): 253, https://doi.org/10.1186/s12967-020-02427-4. [xxxvii] Michael S. Okun et al., “Deep Brain Stimulation in the Internal Capsule and Nucleus Accumbens Region: Responses Observed during Active and Sham Programming,” Journal of Neurology, Neurosurgery & Psychiatry 78, no. 3 (March 1, 2007): 310–14, https://doi.org/10.1136/jnnp.2006.095315. (shrink)

In this paper I explore a brand of scepticism about perceptual experience that takes its start from recent work in psychology and philosophy of mind on change blindness and related phenomena. I argue that the new scepticism rests on a problematic phenomenology of perceptual experience. I then consider a strengthened version of the sceptical challenge that seems to be immune to this criticism. This strengthened sceptical challenge formulates what I call the problem of perceptual presence. I show how this (...) problem can be addressed by drawing on an enactive or sensorimotor approach to perceptual consciousness. Our experience of environmental detail consists in our access to that detail thanks to our possession of practical knowledge of the way in which what we do and sensory stimulation depend on each other. (shrink)

In 1910, Charles Richet suggested that studying individual variations in anaphylactic responses might both open a way to experimental investigation of the biological basis of individuality and help unify the immunological and physiological approaches to biological phenomena. The very opposite would happen however. In the next two decades, physiologists and immunologists interested in anaphylaxis and allergy experienced more and more difficulties in communicating. This divergence between the physiopathological and immunological approaches derived from discrepancies between the experimental systems used by (...) each of these scientific communities. Trying to develop a point of view that took into account all bodily reactions to stimuli, physiologists thought that individual variations between the laboratory animals they used (mainly dogs and cats) constituted important experimental data. Seeking to develop reproducible studies of infection, immunity and 'sensitisation', bacteriologists and immunologists considered that individual variations between the laboratory animals they used (mainly small rodents) constituted 'noise' and not a 'signal'. Each group's loyalty to the experimental models used in their discipline widened the gap between immunological and physiological explanations of allergies and led to the abandonment of studies on the biological basis of individuality. (shrink)

Brentano's innovations in logical theory are considered in the context of his descriptive psychology, with its distinction between differences in quality and in object of mental phenomena. Objections are raised to interpretations that depend on a parallel between Urteil and assertion of a proposition. A more appropriate parallel is drawn between the assertion as subject to description in a metalanguage and the Urteil as secondary object in inner perception. This parallel is then applied so as to suggest a reinterpretation (...) of substitutional quantification, rendering the substitutional interpretation immune to problems that often arise as to the relation between substitutional range and referential range. (shrink)

In Book I of the Ethics, Spinoza rejects any explanation that uses the will of God to explain natural phenomena. In his paper Spinoza’s argument is discussed by looking at a specific example of the view he was criticizing: Maimonides’ account of particularity. We will see that in some ways, Spinoza is right. But we will also see that Maimonides’ argument is not as naïve as a reader of Spinoza might think and that Spinoza’s own position is not immune (...) from Maimonides’ attack on metaphysical determinism. (shrink)

This article will explore the representation of certain mental and somatic phenomena in Beckett’s trilogy of novels Molloy, Malone Dies and The Unnamable, exploring how his understanding of schizophrenia and psychosis informs his representation of the relationship between mind and body. It will also examine recent phenomenological and philosophical accounts of schizophrenia (Louis Sass, Josef Parnas, Shaun Gallagher) that see the condition as a disorder of selfhood and concentrate in it on the disruption to ipseity, a fundamental and pre-reflective (...) awareness of self that leads to a loss of ‘grip’ (in the term of Merleau-Ponty) on concepts and percepts. Beckett’s writing might, it is argued, make such disruptions more tangible and intelligible. The article will also consider John Campbell’s argument that immunity of the first person to error—Sydney Shoemaker’s foundational philosophical idea that we cannot misspeak the first person pronoun—is revoked in states of psychosis, and relate such states to the moments in Beckett’s writing where this immunity is challenged, and quasi-psychotic experiences represented. (shrink)

What enables individually simple insects like ants to act with such precision and purpose as a group? How do trillions of individual neurons produce something as extraordinarily complex as consciousness? What is it that guides self-organizing structures like the immune system, the World Wide Web, the global economy, and the human genome? These are just a few of the fascinating and elusive questions that the science of complexity seeks to answer. In this remarkably accessible and companionable book, leading complex systems (...) scientist Melanie Mitchell provides an intimate, detailed tour of the sciences of complexity, a broad set of efforts that seek to explain how large-scale complex, organized, and adaptive behavior can emerge from simple interactions among myriad individuals. Comprehending such systems requires a wholly new approach, one that goes beyond traditional scientific reductionism and that re-maps long-standing disciplinary boundaries. Based on her work at the Santa Fe Institute and drawing on its interdisciplinary strategies, Mitchell brings clarity to the workings of complexity across a broad range of biological, technological, and social phenomena, seeking out the general principles or laws that apply to all of them. She explores as well the relationship between complexity and evolution, artificial intelligence, computation, genetics, information processing, and many other fields. Richly illustrated and vividly written, Complexity : A Guided Tour offers a comprehensive and eminently comprehensible overview of the ideas underlying complex systems science, the current research at the forefront of this field, and the prospects for the field's contribution to solving some of the most important scientific questions of our time. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Why Poe?Why Not Peirce?Roger SeamonFrederick Crews has twice tried to mock deep interpretation to death, but it won't work. There is, as he himself says, "a desperate need to root around and 'find' some redeeming features of Pooh to hang on to," and thus The Pooh Perplex did not, and Postmodern Pooh will not, put an end to the love affair between literary interpreters and deep meanings.1 The opposition (...) of Plato and Aristotle did not do it in the ancient world,2 and Dr. Johnson was still protesting two millennia later: "They see with great clearness whatever is too remote to be discovered by the rest of mankind, but are totally blind to what lies immediately before them. They discover in every passage some secret meaning, some remote allusion, some artful allegory... which no other reader ever suspected" (Rambler, p. 176). Early in the last century academic critics tried to resist the practice within academe, but they too failed, and Crews himself only gave it up after writing one of the best works of the genre, The Sins of the Fathers.3Disbelieving in literary deep meanings is roughly the equivalent of being an atheist. We have a strong propensity to find them in both natural and cultural phenomena. Stars and entrails are interpreted as symbols of a deeper reality, and we create such devices as the I Ching and the Tarot deck to gain entrance to a hidden world of meaning. Dreams, which straddle nature and culture are, perhaps, the most common object upon which to exercise the impulse, and Hayden White reminds us that this propensity has also been part of our intellectual traditionfrom the time that Plato set the world of ideas over against the world of things and Aristotle set the contemplative life over against the active life as end to means. This Absurdist moment [White is speaking about post-structuralist [End Page 256] literary interpretation] was potentially present from the beginning of modern European humanism, with its gnostic bent, its celebration of scholarship as an end in itself, its notion of privileged readers enjoying the status of priests interpreting the book of life. It was potentially present in modern Western philosophy, with its insistence that things are never what they appear to be but are manifestations of noumenal essences whose reality must be supposed but whose "natures" can never be known.4We are often not content with surface meaning in life and texts, but wish to find what Paul Tillich calls, none too modestly, "ultimate reality," which "characterizes the whole appearing world as non-ultimate, preliminary, transitory and finite," and "it is the awareness of the deceptive character of the surface of everything we encounter which drives one to discover what is below the surface."5There is, however, an oddity that may offer non-believers in deep interpretation some consolation. Philosophical texts, which share many characteristics with literary ones (see below, p. 4, for a discussion of the relevant similarities), are almost wholly immune from deep interpretation. There is no hope for us skeptics that literary deep interpreters will abandon their trade, so all we can do is console ourselves with trying to understand why our rich and beloved surfaces are so often abandoned for the very dubious depths. Crews says that interpreters "yearn to have their 'values' validated by books—the killer app of the 1400s" (Postmodern Pooh, p. 136); yes, but why don't other disciplines, such as history and philosophy, engage in the same practice? What is it about literature that makes it vulnerable? Why, in particular, are philosophical texts almost totally immune to such interpretation? As my title puts it, why Poe, why not Peirce?But why just Poe and Peirce, philosophy and literature, in the first place? There are, of course, many other kinds of discourse, but literary and philosophical texts have an especially intimate relationship. First, they have a canonical status that, for example, history no longer does, and it is the canon that attracts hermeneutic attention. Students of philosophy and literature learn a canon—or did until recently, and that is not true of modern historians, psychologists, and economists. Second... (shrink)

Algorithmic communications pose several challenges to democracy. The three phenomena of filtering, hypernudging, and microtargeting can have the effect of polarizing an electorate and thus undermine the deliberative potential of a democratic society. Algorithms can spread fake news throughout the society, undermining the epistemic potential that broad participation in democracy is meant to offer. They can pose a threat to political equality in that some people may have the means to make use of algorithmic communications and the sophistication to (...) be immune from attempts at manipulation, while other people are vulnerable to manipulation by those who use these means. My concern here is with the danger that algorithmic communications can pose to political equality, which arises because most citizens must make decisions about what and who to support in democratic politics with only a sparse budget of time, money, and energy. Algorithmic communications such as hypernudging and microtargeting can be a threat to democratic participation when persons are operating in environments that do not conduce to political sophistication. This constitutes a deepening of political inequality. The political sophistication necessary to counter this vulnerability is rooted for many in economic life and it can and ought to be enhanced by changing the terms of economic life. (shrink)

Through a warm and passionate investigation of the most fundamental properties of human behaviour, Psychotherapy and Science shows how a scientific foundation for psychotherapy is both necessary and feasible. Addressing psychotherapy's need for a coherent theoretical grounding, the book argues that there are striking parallels between the emotion-processing mind and phenomena that have been scientifically observed and charted in the areas of evolution, the immune system and the brain. The idea that scientific theories might be applied to psychotherapy is (...) thoroughly explored in a surprisingly accessible manner. Throughout the book, the ways in which science has a bearing on the clinical techniques and practice of psychotherapy are emphasized, and priority is given to the needs of psychotherapists to focus their theoretical and clinical efforts on understanding the deep, evolved factors behind human suffering, deception, self-limitations and death anxiety. This rare and engaging insight into a scientific quest for better psychotherapeutic knowledge offers a truly original way through the current impasse of ever-divergent theories, and is one of the most cogent challenges to psychotherapy in recent times. It is essential reading for all training and practising psychotherapists, and for those involved in related research. (shrink)

De Martino offered Momigliano an opportunity to reflect on his own analogous yet different experience. The connection between the study of prehistory and the threat of the end of the world, and more generally, the idea that we need to respond to today's crisis by enlarging historical research to unknown and unpredictable phenomena might lead us to conclude that, at least momentarily, Momigliano's and De Martino's paths had touched. In reality, however, as Momigliano lucidly saw, theirs were parallel paths (...) that could never meet. Studies that culminated in Il Mondo Magico had carried De Martino, albeit temporarily, outside Croceanism, and toward a more radical historicism immune from ethnocentric limitations, in particular with regard to Cassirer's works. Momigliano's detachment from Croceanism can be located between two divergent statements: that the sun had set on the idea of antiquitates, while also looking forward to the affirmation of a new antiquarianism under the guise of sociology or anthropology. It became increasingly clear as the years passed that for Momigliano all forms of historicism were unacceptable because they were threatened by relativism. (shrink)

Given the complexity of most phenomena, we have to delegate much epistemic work to other knowers and we must find reasons for relying on these specific knowers and not others. In our societies, these other knowers are often called experts and we rely on their epistemic authority more and more. For many complex phenomena such as climate change, genetically modified crops, and immunization, the experts that are called upon are scientific experts. For that reason, finding good reasons and (...) justification for deferring to their knowledge is of paramount societal importance. As we shall see, many have analyzed this epistemic dependence on scientific experts and have tried to show in what contexts are there good... (shrink)

Mereological nihilism (henceforth just "nihilism") is the thesis that composition never occurs. Nihilism has often been defended on the basis of its theoretical simplicity, including its ontological simplicity and its ideological simplicity (roughly, nihilism's ability to do without primitive mereological predicates). In this paper I defend nihilism on the basis of the theoretical unification conferred by nihilism, which is, roughly, nihilism's capacity to allow us to take fewer phenomena as brute and inexplicable. This represents a respect in which nihilism (...) enjoys greater theoretical simplicity than its rivals which has not yet been explored, and which is immune to many of the objections which have been leveled against previous arguments for nihilism from nihilism's theoretical simplicity. Composition as identity might be thought to confer a similar degree of theoretical unification as nihilism. I end the paper by arguing that this is not the case. (shrink)

It is common for scholars sympathetic to religion – from Friedrich Schleiermacher to the present – to describe the modern critics of religious experience as reductionist. By this they mean these critics do not respect religion for what it is; they rather ‘attempt to assimilate religion to nonreligious phenomena’,1 say, primitive science or metaphysics. Needless to say, these scholars consider this incorrect.Into this scene strides Wayne Proudfoot. In his award‐winning book Religious Experience2 he sets out to scrutinize this accusation (...) and rehabilitate the modern critics. He dismisses this accusation as a protective strategy to render religious claims immune to rational critique. His rehabilitation program is based on a distinction he draws between two kinds of reduction – descriptive and explanatory. This distinction has so caught the imagination of philosophers that it has found its way into textbooks.3 On the other hand, the book is also controversial; needless to say, its claims are problematic for believers.The purpose of my paper is not to offer a comprehensive critique of his book, but only of his methodology, or the lack thereof, where methodology is understood as an integrated set of tools used for inquiry. I argue that although he proposes description and explanation as appropriate instruments for the study of religious experience, the two do not constitute a methodology, because his descriptions play no role in his explanations; rather, both go their separate ways. I argue that explanation must be guided by description. Moreover, I distinguish three kinds of inquiry, each calling for a different kind of description. The kind of description Proudfoot recommends is appropriate for genetic inquiry into how particular experiences came about, but not for a conceptual inquiry into the constitutive elements of religious experience. He knows lots of trees (particular experiences), but misses the wood (the nature of religious experience). Thus my title.The paper is divided into three parts. First is a brief presentation of Proudfoot's thesis. A second part analyses three different kinds of inquiry; it shows that genetic and epistemic explanations are logically independent and irreducible one to another. These different types of inquiry call for distinct types of description, and these descriptions in turn guide the explanation that will be considered satisfactory. The context‐sensitivity of descriptions, and their relation to explanation is dealt with in the final part. Let us start with Proudfoot's contention. (shrink)

External reality is not moved by our personal dramas; even when our world is collapsing, the world continues its normal course, as if nothing had happened. Of course we know that the most poignant human suffering will not stop the sun from shining or the world from turning. Yet there are moments when the disharmony between objective reality and our own emotional state is painful and even surprising. It seems as if the world is provocatively uninterested in what is most (...) dear to us.The awareness of this rift is evoked in the first sentence of Borges’ well-known story translated into Dutch under the title De Aleph, "On the harrowing morning in February when Beatriz Viterbo died... I saw that the iron poster boards in the Plaza Constitución were being pasted over with some type of advertising for light cigarettes; this struck me, for I understood that the restless, enormous universe was already withdrawing from her, and that this was the first change in an endless series".What is the theoretical relevance of this experience, often roused by poetry and prose, but seldom discussed by philosophers? Is Borges referring to a purely subjective experience from which no conclusion can be drawn, or does he speak of an experience containing an important theoretical insight? Regardless, our ability to undergo this experience is evidently independent of our favourite philosophical concepts. Even someone who adheres to a theory that accepts a meaningful reality can experience this rift when he observes the sun shining triumphantly on a day of mourning. Similarly, someone having no metaphysical belief in a meaningful reality can remain immune to the type of rift Borges describes.Yet it cannot be denied that this rift experience is strengthened and legitimized by an important development in knowledge. The science has evoked a world view that strictly separates objective facts from subjective values. The reality presented by science, is not an inspired relationship or meaningful construction where humanity finds its place and from which it derives its dignity. Laws discovered by science say nothing of good or evil and contain no message on the meaning of life. Science is a source of trustworthy information not elevating, inspiring or comforting concepts. From a scientific viewpoint, knowledge of objective reality has nothing to do with insights people use to orient their lives.This separation of knowledge and wisdom contrasts sharply with a traditional view where knowledge of the most fundamental characteristics of reality also offers an insight in the meaning of human life. Nietzsche described this contrast as follows: while people have always tended to believe that what concerns them most also lies at the heart of reality, they must now realize that their moral, religious or aesthetic values merely form a superficial world of appearances; what elicits wonder or strong emotion is only a blossom on a reality that, in its deeper roots, is not at all beautiful or moving.The disenchantment brought on by science creates a breach or rift. Everything we experience as mysterious, enchanted or moving, appears also to exist as a reality coldly and neutrally described by science. Science demystified the rainbow that once appeared as a mysterious, divine phenomenon: what had always seemed wondrous can apparently be explained by the same natural laws that regulate the most banal or prosaic phenomena. (shrink)

This paper reviews and discusses two extensions of Bohmian Mechanics to the phenomena of particle creation and annihilation typically observed in Quantum Field Theory : the so-called Bell-type Quantum Field Theory and the Dirac Sea representation. These theories have a secure metaphysical basis as they postulate a particle ontology while satisfying the requirements imposed by the Primitive Ontology approach to quantum physics. Furthermore, their methodological perspective intentionally provides a set of rules to immunize physical theories to the conceptual and (...) technical problems plaguing the standard formulation of Quantum Mechanics and QFT. A metaphysical analysis of both theories will be given, emphasizing the relevant features of each proposal. Finally, it will be acknowledged that, despite the metaphysical virtues and niceties of these frameworks, ultimately they do not provide definitive answers to other cogent foundational issues in QFT. Thus, these theories should be considered as partial solutions to the problems raised by the quantum theory of fields. This situation can be considered incentive for further research. (shrink)

We argue that traditional formulations of the reduction thesis that tie it to privileged relational operations do not suffice for Peirce’s justification of the categories and invite the charge of gerrymandering to make it come out as true. We then develop a more robust invariant formulation of the thesis, one that is immune to that charge, by explicating the use of triads in any relational operations. The explication also allows us to track how Thirdness enters the structure of higher order (...) relations and even to propose a numerical measure of it. Our analysis reveals new conceptual phenomena when negation or disjunction are used to compound relations. (shrink)

Many manipulation arguments against compatibilism rely on the claim that manipulation is relevantly similar to determinism. But we argue that manipulation is nothing like determinism in one relevant respect. Determinism is a "universal" phenomenon: its scope includes every feature of the universe. But manipulation arguments feature cases where an agent is the only manipulated individual in her universe. Call manipulation whose scope includes at least one but not all agents "existential manipulation." Our responsibility practices are impacted in different ways by (...) universal and existential phenomena. And this is a relevant difference, especially on Strawsonian approaches to moral responsibility, which take facts about our responsibility practices to be deeply connected to the nature of responsibility itself. We argue that Strawsonian accounts of moral responsibility are immune to manipulation arguments, and no attempt to modify the scope of manipulation or determinism featured in these arguments will help incompatibilists secure their desired conclusion. (shrink)

I address the objection that the concept of racism has become overly inflated. Critics of the conceptual inflation of “racism” argue that theories of institutional racism engage in untoward conceptual inflation insofar as they undermine our moral understanding of racial phenomena, hinder our ability to explain the causes of racial inequality, and even undercut struggles for racial justice. I develop an original account of institutional racism and show that it is immune to all three versions of the conceptual inflation (...) challenge. (shrink)

Brentano's innovations in logical theory are considered in the context of his descriptive psychology, with its distinction between differences in quality and in object of mental phenomena. Objections are raised to interpretations that depend on a parallel between Urteil and assertion of a proposition. A more appropriate parallel is drawn between the assertion as subject to description in a metalanguage and the Urteil as secondary object in inner perception. This parallel is then applied so as to suggest a reinterpretation (...) of substitutional quantification, rendering the substitutional interpretation immune to problems that often arise as to the relation between substitutional range and referential range. (shrink)

Self-deception entails apparent conceptual paradoxes and poses the dilemma between two competing needs: the need for stability of the self-concept, on the one hand, and the need to accept reality, on the other. It is argued, first, that conceptual difficulties can be avoided by distinguishing two levels of explanation. Whereas, in a personal language, “the person” deceives him- or her-self, a cognitive approach explains this self-deception by reference to the interplay of cognitive processes of which the person is not aware. (...) Second, the tension between stability and adjustment of the self can be resolved by self-immunization, which maintains the stability of central self-conceptions by adjusting peripheral aspects and their diagnostic value for the central concepts. Processes of self-immunization were investigated in a series of studies operating on both levels of explanation. Implications for psychological explanations of personal phenomena such as self-images and self-insight are discussed. (shrink)

Mind-body interactions have been the subject of debate for many generations. However, it is only in recent years that these interactions have become the subject of rigorous scientific enquiry. In recent years there have been major advances in our understanding of the stress process, the endocrine and immune systems, and the methodologies used to investigate these phenomena. As a result, we have witnessed an explosion of research activity in the field known as psychoneuroimmunology - the study of psychological processes (...) and their interaction with the nervous and immune systems. This book presents an up to date account of the human evidence in this field. The first three chapters introduce the reader to the biological systems at the heart of mind/body interactions and the methods used to investigate them. Thereafter, each chapter deals with a separate clinical entity; examining the theoretical basis for mind/body interactions; the associated empirical evidence and directions for future research. With each chapter written by international experts in the field, it provides the reader with an up to date account of the research evidence in the rapidly evolving field of psychoneuroimmunology. (shrink)

The idiotypic network theory (INT) was conceived by the Danish immunologist Niels Kaj Jerne in 1973/1974. It proposes an overall view of the immune system as a network of lymphocytes and antibodies. The paper tries to offer a reconstruction of the genesis of the theory, now generally discarded and of mostly historical interest, first of all, by taking into account the context in which Jerne’s theoretical proposal was advanced. It is argued the theory challenged, in a sense, the supremacy of (...) the clonal selection theory (CST), this being regarded as the predominant paradigm in the immunological scenario. As CST found shortcomings in explaining certain phenomena, anomalies, one could view INT as a competing paradigm claiming to be able to make sense of such phenomena in its own conceptual framework. After a summary outline of the historical background and some relevant terminological elucidations, a narrative of the various phases of elaboration of the theory is proposed, up to its official public presentation. (shrink)

The basic task of the essay is to exhibit science as a rational enterprise. I argue that in order to do this we need to change quite fundamentally our whole conception of science. Today it is rather generally taken for granted that a precondition for science to be rational is that in science we do not make substantial assumptions about the world, or about the phenomena we are investigating, which are held permanently immune from empirical appraisal. According to this (...) standard view, science is rational precisely because science does not make a priori metaphysical presuppositions about the world forever preserved from possible empirical refutation. It is of course accepted that an individual scientist, developing a new theory, may well be influenced by his own metaphysical presuppositions. In addition, it is acknowledged that a successful scientific theory, within the context of a particular research program, may be protected for a while from refutation, thus acquiring a kind of temporary metaphysical status, as long as the program continues to be empirically progressive. All such views unite, however, in maintaining that science cannot make permanent metaphysical presuppositions, held permanently immune from objective empirical evaluation. According to this standard view, the rationality of science arises, not from the way in which new theories are discovered, but rather from the way in which already formulated theories are appraised in the light of empirical considerations. And the fundamental problem of the rationality of science--the Humean problem of induction--concerns precisely the crucial issue of the rationality of accepting theories in the light of evidence. In this essay I argue that this widely accepted standard conception of science must be completely rejected if we are to see science as a rational enterprise. In order to assess the rationality of accepting a theory in the light of evidence it is essential to consider the ultimate aims of science. This is because adopting different aims for science will lead us, quite rationally, to accept different theories in the light of evidence. I argue that a basic aim of science is to explain. At the outset science simply presupposes, in a completely a priori fashion, that explanations can be found, that the world is ultimately intelligible or simple. In other words, science simply presupposes in an a priori way the metaphysical thesis that the world is intelligible, and then seeks to convert this presupposed metaphysical theory into a testable scientific theory. Scientific theories are only accepted insofar as they promise to help us realize this fundamental aim. At once a crucial problem arises. If scientific theories are only accepted insofar as they promise to lead us towards articulating a presupposed metaphysical theory, it is clearly essential that we can choose rationally, in an a priori way, between all the very different possible metaphysical theories that can be thought up, all the very different ways in which the universe might ultimately be intelligible. For holding different aims, accepting different metaphysical theories conceived of as blueprints for future scientific theories will, quite rationally, lead us to accept different scientific theories. Thus it is only if we can choose rationally between conflicting metaphysical blueprints for future scientific theories that we will be in a position to appraise rationally the acceptability of our present day scientific theories. We thus face the crucial problem: How can we choose rationally between conflicting possible aims for science, conflicting metaphysical blueprints for future scientific theories? It is only if we can solve this fundamental problem concerning the aims of science that we can be in a position to appraise rationally the acceptability of existing scientific theories. There is a further point here. If we could choose rationally between rival aims, rival metaphysical blueprints for future scientific theories, then we would in effect have a rational method for the discovery of new scientific theories! Thus we reach the result: there is only a rational method for the appraisal of existing scientific theories if there is a rational method of discovery. I shall argue that the aim-oriented theory of scientific inquiry to be advocated here succeeds in exhibiting science as a rational enterprise in that it succeeds in providing a rational procedure for choosing between rival metaphysical blueprints: it thus provides a rational, if fallible, method of discovery, and a rational method for the appraisal of existing scientific theories--thus resolving the Humean problem. In Part I of the essay I argue that the orthodox conception of science fails to exhibit science as a rational enterprise because it fails to solve the Humean problem of induction. The presuppositional view advocated here does however succeed in resolving the Humean problem. In Part II of the essay I spell out the new aim-oriented theory of scientific method that becomes inevitable once we accept the basic presuppositional viewpoint. I argue that this new aim oriented conception of scientific method is essentially a rational method of scientific discovery, and that the theory has important implications for scientific practice. (shrink)