In England, higher education institutions, together with the schools whose staff they train, are being required to incorporate synthetic phonics as one of the key approaches to the teaching of reading. Yet even if synthetic phonics can be identified as one of the component ‘skills’ of reading, an assumption vigorously contested in this paper, it does not follow that it can or should be taught explicitly and independently of reading for meaning. Imposing such a ‘method’ is, (...) at a deep level, incompatible with teachers acting as teachers and potentially constitutes a kind of abuse of early readers. Moreover, because of the conceptual difficulties confronting any attempt to specify synthetic phonics as an approach, there cannot exist, in principle, empirical research that actually supports its value. Current policy in England since the Rose Report, at least, assumes the opposite. All this cannot be dismissed as a little local difficulty for England concerning the teaching of reading English with all its spelling irregularities: there are broader implications for the relationship between research and teaching, together with continuing tendencies to impose ‘teacher proof’ approaches on schools and their staff in many countries. (shrink)

In England, current government policy on children's reading is strongly prescriptive, insisting on the delivery of a pure and exclusive form of synthetic phonics, where letter sounds are learned and blended in order to ‘read’ text. A universally imposed phonics ‘check’ is taken by all five year olds and the results are widely reported. These policies are underpinned by the claim that research has shown systematic synthetic phonics to be the most effective way of teaching (...) children to read. Andrew Davis argues that there is a basic problem with this claim. Whatever it is that empirical researchers take themselves to be doing when they investigate synthetic phonics, they are not investigating a specifiable method of teaching reading. This is for two reasons. First, there are no such things as specifiable methods of teaching. Teaching is a vastly complex human activity involving contextual and reactive practical judgments that are responsive to the myriad contingencies of classroom life. The idea that teachers might proceed by way of prescribed methods rather than practical judgments is simply a fantasy. Second, teaching children to correlate letter combinations with sounds, and to blend sounds into sequences, is not teaching them to read. Reading is a matter of grasping meaning conveyed by text. While sustained attention to letter-sound correspondences can be helpful to some novice readers, we should neither assume that it is helpful to all nor confuse mastery of such correspondences with the ability to read. Davis's challenge to government policy on the teaching of reading, and to the empirical research that supposedly underpins it, is timely, radical and compelling. The zeal with which synthetic phonics is championed by its advocates has been remarkably effective in pushing it to the top of the educational agenda; but we should not mistake zeal for warrant. (shrink)

Synthetic biology is an emerging engineering discipline that attempts to design and rewire biological components, so as to achieve new functions in a robust and predictable manner. The new tools and strategies provided by synthetic biology have the potential to improve therapeutics for neurodegenerative diseases. In particular, synthetic biology will help design small molecules, proteins, gene networks, and vectors to target disease‐related genes. Ultimately, new intelligent delivery systems will provide targeted and sustained therapeutic benefits. New treatments will (...) arise from combining ‘protect and repair’ strategies: the use of drug treatments, the promotion of neurotrophic factor synthesis, and gene targeting. Going beyond RNAi and artificial transcription factors, site‐specific genome modification is likely to play an increasing role, especially with newly available gene editing tools such as CRISPR/Cas9 systems. Taken together, these advances will help develop safe and long‐term therapies for many brain diseases in human patients. (shrink)

Synthetic approaches to social interaction support the development of a second-person neuroscience. Agent-based models and psychological experiments can be related in a mutually informing manner. Models have the advantage of making the nonlinear brainenvironmentbrain system as a whole accessible to analysis by dynamical systems theory. We highlight some general principles of how social interaction can partially constitute an individual's behavior.

Synthetic biology aims at making life easier to an engineer by applying biotechnology engineering principles such as standardization and modularity. I argue that living organisms are inherently non-machine, non-standardized entities and that the current state-of-the-art in SynBio combines pre- and post-standardization efforts, in a scenario without evidence that full standardization in biology is even possible. I finally propose a new view on SynBio based on purpose rather than on technicalities.

It is a most commonly accepted hypothesis that life originated from inanimate matter, somehow being a synthetic product of organic aggregates, and as such, a result of some sort of prebiotic synthetic biology. In the past decades, the newly formed scientific discipline of synthetic biology has set ambitious goals by pursuing the complete design and production of genetic circuits, entire genomes or even whole organisms. In this paper, I argue that synthetic biology might also shed some (...) novel and interesting perspectives on the question of the origin of life, and that, in addition, it might challenge our most commonly accepted definitions of life, thereby changing the ways we might think about life and its origin. (shrink)

Through the relatively new science and technology known as synthetic biology, scientists are attempting to create useful new life forms. Any attempt to “create life” inevitably prompts some to ask whether man is trespassing into areas properly reserved for a divine creator. The potential creative power of synthetic biology raises this concern to a level that has not been known before. Thus a new chapter in the history of the relationship between science and religion is being written. This (...) article presents some of the scholarly perspectives on that chapter. (shrink)

We attempt to justify the use of synthetic biology in response to the climate crisis, based on the premise that it is impossible to avert runaway climate change without sequestering sufficient greenhouse gases (GHG), which could only become possible through Negative Emissions Technologies (NETs). Then, moving from a consequentialist standpoint, we acquiesce to how the consequences of using NETs through synthetic biology are preferable to the catastrophic consequences of runaway climate change. In conclusion, we show how our analysis (...) of synthetic biology resonates with a zoecentric view of climate science and ethics. (shrink)

ABSTRACT In this paper, I advance a new interpretation of the argumentative structure of the third Critique, which in turn clarifies the connection between its two apparently unrelated parts. I propose to read the third Critique as a response to Kant’s question of hope, which concerns the satisfaction of reason’s practical and theoretical interests. On this proposal, while the first part on aesthetics describes what we—as possessors of theoretical reason – may hope for, the second part, on teleology, describes what (...) we – as possessors of practical reason – may hope for. The main question of the third Critique is, ‘What may we hope if we act as we should, i.e. act rationally?’ Kant’s implicit answer is, ‘to attain the ideals of reason, which leads to happiness as a consequence of it.’ This novel reconstruction of the argumentative structure of the third Critique contributes to the literature by (i) explaining how the two parts of the third Critique on aesthetics and teleology are connected, (ii) clarifying how the ideals of reason are connected to hope and happiness, and (iii) showing how the spheres of nature and freedom can be synthetically unified through the faculty of judgment. (shrink)

One of the most contested areas in relation to literacy has been the teaching of reading. The British National Literacy Strategy (NLS) was intended to foreclose the reading debate by taking a clear position on the teaching of reading and prescribing this for all schools. National policy makers have claimed that the NLS is underpinned by research evidence. The central question that informs this paper is: has the research evidence on the teaching of reading demonstrated that the greater emphasis on (...) phonics evident in the NLS Framework for Teaching is justified? Empirical evidence in a number of key areas is reviewed: seminal work; teaching method evaluations; longitudinal evidence and the DfEE review of research and related evidence. It is concluded that there is a weak link between research and the prescribed phonics teaching in the Framework, and that changes should be made to reflect more accurately the research evidence. (shrink)

Mammalian synthetic biology holds the promise of providing novel therapeutic strategies, and the first success stories are beginning to be reported. Here we focus on the latest generation of mammalian transgene control devices, highlight state‐of‐the‐art synthetic gene network design, and cover prototype therapeutic circuits. These will have an impact on future gene‐ and cell‐based therapies and help bring drug discovery into a new era. The inventory of biological parts that are essential for life on this planet is becoming (...) increasingly complete. The postgenomic era has provided encyclopedic information on gene‐function correlations and systems biology is now delivering comprehensive details on the dynamics of biochemical reaction networks in living organisms. The time has come to reassemble these catalogued items and design new biological devices and systems with novel and useful functionality in a rational and systematic manner. This is the premise of synthetic biology, a constructive systems biology discipline likely to become the life science revolution of the 21st century. (shrink)

Biologists are nearing the creation of the first fully synthetic eukaryotic genome. Does this mean that we still soon be able to create genomes that are parts of an existing genetic lineage? If so, it might be possible to bring back extinct species. But do genomes that are synthetically assembled, no matter how similar they are to native genomes, really belong to the genetic lineage on which they were modelled? This article will argue that they are situated within the (...) same genetic lineage. To see why requires closely examining whether material overlap between parents and offspring is a necessary feature of biological reproduction. The processes used to create synthetic genomes shows that these processes are a form of scaffolded reproduction because they use external machinery and take ownership of the material parts used to create synthetic genomes. Closely examining these processes also reveals, surprisingly, that ‘synthetic reproduction’ can take place between entities that don’t participate in the same biological lineages. 1Introduction2The Argument for Lineage-less Genomes3Synthetic Eukaryotic Chromosomes and Material Overlap4Biological Reproduction, Material, and Information5Synthetic Reproductive Processes and Their Implications. (shrink)

Many scientific models in biology are how-possibly models. These models depict things as they could be, but do not necessarily capture actual states of affairs in the biological world. In contemporary philosophy of science, it is customary to treat how-possibly models as second-rate theoretical tools. Although possibly important in the early stages of theorizing, they do not constitute the main aim of modelling, namely, to discover the actual mechanism responsible for the phenomenon under study. In the paper it is argued (...) that this prevailing picture does not do justice to the synthetic strategy that is commonly used in biological engineering. In synthetic biology, how-possibly models are not simply speculations or eliminable scaffolds towards a single how-actually model, but indispensable design hypotheses for a field whose ultimate goal is to build novel biological systems. The paper explicates this by providing an example from the study of alternative genetic systems by synthetic biologist Steven Benner and his group. The case will also highlight how the method of synthesis, even when it fails, provides an effective way to limit the space of possible models for biological systems. (shrink)

The guiding thread of the paper is the diagnosis that the advanced division of cognitive labor (that is, intellectual specialization) engenders a set of perennial, political and epistemic challenges (Millgram 2015) that, simultaneously, also generate opportunities for philosophy. In this paper, I re-characterize the nature of synthetic philosophy as a means to advance and institutionalize philosophy. For my definition of synthetic philosophy see section 2. In section 1, I treat Plato’s Republic as offering two models to represent philosophy's (...) relationship to the other sciences within the advanced division of labor. I highlight that for Plato intellectual specialization is central not just to economic, but also to political life. And, yet, that the very dispersion of scientific expertise, and its esoteric nature, also generates non-trivial challenges to the recognition and political utilization of knowledge. From Plato we can infer that in imperfect circumstances, philosophy’s self-constitution is, in part, a response to these challenges in political epistemology. However, how philosophy is institutionalized differs through time. In section 2, I re-introduce my conceptualization of synthetic philosophy and restate it. This makes visible that synthetic philosophy is already widely practiced in the profession as philosophy of the special sciences, PPE, formal modelling, public philosophy, etc. I use recent work by Dorst (2023) to illustrate synthetic philosophy and to identify some of the processes that give rise to the need for it. In sections 2-3, I contrast my account with the evolving ways that Philip Kitcher has conceptualized synthetic philosophy in order to make more precise the version promoted here. I do so not just because Kitcher and I use the same term, ‘synthetic philosophy,’ but because the temptations inherent in Kitcher’s approach should be resisted. -/- . (shrink)

The term \synthetic phenomenology" refers to: 1) any attempt to characterize the phenomenal states possessed, or modeled by, an artefact ; or 2) any attempt to use an artefact to help specify phenomenal states. The notion of synthetic phenomenology is clari¯ed, and distinguished from some related notions. It is argued that much work in machine consciousness would bene¯t from being more cognizant of the need for synthetic phenomenology of the ¯rst type, and of the possible forms it (...) may take. It is then argued that synthetic phenomenology of the second type looks set to resolve some problems confronted by standard, nonsynthetic attempts at characterizing phenomenal states. An example of the second form of synthetic phenomenology is given. (shrink)

The recent discussion of fictional models has focused on imagination, implicitly considering fictions as something nonconcrete. We present two cases from synthetic biology that can be viewed as concrete fictions. Both minimal cells and alternative genetic systems are modal in nature: they, as well as their abstract cousins, can be used to study unactualized possibilia. We approach these synthetic constructs through Vaihinger’s notion of a semi-fiction and Goodman’s notion of semifactuality. Our study highlights the relative existence of such (...) concrete fictions. Before their realizations neither minimal cells nor alternative genetic systems were any well-defined objects, and the subsequent experimental work has given more content to these originally schematic imaginings. But it is as yet unclear whether individual members of these heterogeneous groups of somewhat functional synthetic constructs will eventually turn out to be fully realizable, remain only partially realizable, or prove outright impossible. (shrink)

:This article explores the ethical issues that have been identified in emerging technologies, from early genetic engineering to synthetic biology. The scientific advances in the field form a continuum, and some ethical considerations can be raised time and again when new developments occur. An underlying concern is the cumulative effect of scientific advances and ensuing technological innovation that can change our understanding of life and humanity.

This paper introduces Chinese synthetic verbs and analyses their contributions to debates in manner/result complementarity studies and cognitive typology studies. Chinese synthetic verbs simultaneously express manner information and path/result information, but encode them into separate root slots under Beavers and Koontz-Garboden’s (2012. Manner and result in the roots of verbal meaning. Linguistic Inquiry 43(3). 331–369) scopal modifier test, so they differ from English “manner+result verbs” and further challenge the manner/result complementarity hypothesis. Synthetic verbs followed by redundant path/result (...) verbs constitute double-framing structures that twice encode the framing information, and the non-motion case, i.e., the “synthetic verb+result verb” structure, supplements Croft et al.’s (2010. Revising Talmy’s typological classification of complex event constructions. In Hans C. Boas (ed.), Contrastive studies in construction grammar, vol. 10, 201–235. Amsterdam & Philadelphia: John Benjamins Publishing Company) classification that only includes the motion case, so that Chinese synthetic verbs complement the discussion on double-framing structures. This paper thereby further falsifies the manner/result complementarity hypothesis and provides an overall illustration of the double-framing structure in cognitive typology. This paper also illustrates the diachronic changes of manner, which might be universal and await further investigation. (shrink)

This paper analyses conceptual and experimental work in synthetic biology on different types of interactions considered as minimal examples or models of communication. It discusses their pertinence and relevance for the wider understanding of this biological and cognitive phenomenon. It critically analyses their limits and it argues that a conceptual framework is needed. As a possible solution, it provides a theoretical account of communication based on the notion of organisation, and characterised in terms of the functional influence exerted by (...) the sender upon the receiver. It shows that this account can be operationalised in synthetic biology, and that it can supply criteria and guidelines for the design and evaluation of synthetic models. (shrink)

Synthetic biology is often described as a project that applies rational design methods to the organic world. Although humans have influenced organic lineages in many ways, it is nonetheless reasonable to place synthetic biology towards one end of a continuum between purely ‘blind’ processes of organic modification at one extreme, and wholly rational, design-led processes at the other. An example from evolutionary electronics illustrates some of the constraints imposed by the rational design methodology itself. These constraints reinforce the (...) limitations of the synthetic biology ideal, limitations that are often freely acknowledged by synthetic biology’s own practitioners. The synthetic biology methodology reflects a series of constraints imposed on finite human designers who wish, as far as is practicable, to communicate with each other and to intervene in nature in reasonably targeted and well-understood ways. This is better understood as indicative of an underlying awareness of human limitations, rather than as expressive of an objectionable impulse to mastery over nature. (shrink)

Synthetic biology research is often described in terms of programming cells through the introduction of synthetic genes. Genetic material is seemingly attributed with a high level of causal responsibility. We discuss genetic causation in synthetic biology and distinguish three gene concepts differing in their assumptions of genetic control. We argue that synthetic biology generally employs a difference-making approach to establishing genetic causes, and that this approach does not commit to a specific notion of genetic program or (...) genetic control. Still, we suggest that a strong program concept of genetic material can be used as a successful heuristic in certain areas of synthetic biology. Its application requires control of causal context, and may stand in need of a modular decomposition of the target system. We relate different modularity concepts to the discussion of genetic causation and point to possible advantages of and important limitations to seeking modularity in synthetic biology systems. (shrink)

Synthetic biology presents a challenge to traditional accounts of biology: Whereas traditional biology emphasizes the evolvability, variability, and heterogeneity of living organisms, synthetic biology envisions a future of homogeneous, humanly engineered biological systems that may be combined in modular fashion. The present paper approaches this challenge from the perspective of the epistemology of technoscience. In particular, it is argued that synthetic-biological artifacts lend themselves to an analysis in terms of what has been called ‘thing knowledge’. As such, (...) they should neither be regarded as the simple outcome of applying theoretical knowledge and engineering principles to specific technological problems, nor should they be treated as mere sources of new evidence in the general pursuit of scientific understanding. Instead, synthetic-biological artifacts should be viewed as partly autonomous research objects which, qua their material-biological constitution, embody knowledge about the natural world—knowledge that, in turn, can be accessed via continuous experimental interrogation. (shrink)

In this essay, I discuss Dennett’s From Bacteria to Bach and Back: The Evolution of Minds and Godfrey Smith’s Other Minds: The Octopus and The Evolution of Intelligent Life from a methodological perspective. I show that these both instantiate what I call ‘synthetic philosophy.’ They are both Darwinian philosophers of science who draw on each other’s work. In what follows I first elaborate on synthetic philosophy in light of From Bacteria and Other Minds; I also explain my reasons (...) for introducing the term; and I close by looking at the function of Darwinism in contemporary synthetic philosophy. (shrink)

I discuss the moral significance of artificial life within synthetic biology via a discussion of Douglas, Powell and Savulescu's paper 'Is the creation of artificial life morally significant’. I argue that the definitions of 'artificial life’ and of 'moral significance’ are too narrow. Douglas, Powell and Savulescu's definition of artificial life does not capture all core projects of synthetic biology or the ethical concerns that have been voiced, and their definition of moral significance fails to take into account (...) the possibility that creating artificial life is conditionally acceptable. Finally, I show how several important objections to synthetic biology are plausibly understood as arguing that creating artificial life in a wide sense is only conditionally acceptable. (shrink)

Deepfakes and other forms of synthetic media are widely regarded as serious threats to our knowledge of the world. Various technological responses to these threats have been proposed. The reactive approach proposes to use artificial intelligence to identify synthetic media. The proactive approach proposes to use blockchain and related technologies to create immutable records of verified media content. I argue that both approaches, but especially the reactive approach, are vulnerable to a problem analogous to the ancient problem of (...) the criterion—a line of argument with skeptical implications. I argue that, while the proactive approach is relatively resistant to this objection, it faces its own serious challenges. In short, the proactive approach would place a heavy burden on users to verify their own content, a burden that is exacerbated by and is likely to exacerbate existing inequalities. (shrink)

A range of views on the morality of synthetic biology and its place in public policy and political discourse.

The purpose of this paper is to analyze the theoretical commitments of autopoietic enactivism in relation to Errol E Harris’s dialectical holism in the interest of establishing a common metaphysical ground. This will be undertaken in three stages. First, it is argued that Harris’s reasoning provides a means of developing enactivist ontology beyond discussions limited to cognitive science and into domains of metaphysics that have traditionally been avoided by phenomenologists. Here, I maintain enactivist commitments are consistent with Harris’s reasoning from (...) certain synthetic a priori first principles, to his derivation of a teleological anthropic principle, which asserts the necessity of consciousness within the cosmos. Second, it is proposed that Steven Rosen’s long-standing proposal for a topology of phenomenology may provide a common logical foundation for both Harris and enactivists regarding anthropic reasoning. Third, it is argued that a pragmatic approach to process ontology is the most rigorous way of responding to the realism/anti-realism concerns that inevitably follow. If successful, this work will update Harris’s arguments with contemporary scientific and philosophical terminology and extend enactivism from philosophy of mind, into a general phenomenological ontology. (shrink)

In this short contribution we explore the historical roots of recent synthetic approaches in biology and try to assess their real potential, as well as identify future hurdles or the reasons behind some of the main difficulties they currently face. We suggest that part of these difficulties might not be just the result of our present lack of adequate technical skills or understanding, but could spring directly from the nature of the biological phenomenon itself. In particular, if life is (...) conceived as autonomy in open-ended evolution, which would help to explain the highly complex and dynamic organization of the simplest known organisms (i.e., genetically-instructed cellular metabolisms), external synthetic implementations of such systems, or interventions on them, are bound to interfere with some of their characteristic transformation processes, both at the ontogenetic and phylogenetic scales. In any case, this will prove very revealing and productive, technologically and scientifically speaking, since the knowledge gathered from those implementations/interventions will be extremely valuable in establishing our capacities and limitations to fully comprehend, utilize, and expand the living domain as we know it today. (shrink)

The synthetic experience can be understood as the natural experience extended through technological means. These means are usually designed to immerse a person or people into a representation of reality, being that reality is one of being immersed in a task, a state of mind or an imagined space, or a combination of them. To represent reality, technology is built around the human perceptual system that connects with the focus of its attention towards the outside world. In handling reality, (...) the human perceptual system also extends inwards, to patterns of reasoning where the structure of the body, that is, the perceptual system itself, models the organization of ideas and interaction. Therefore, a synthetic experience has unique potential to allow for interaction with structures of the mind. (shrink)

The aim of synthetic biology is to rationally design devices, systems, and organisms with desired innovative and useful functions (Slusarczyk, Lin, and Weiss 2012). To achieve this aim, synthetic biology uses a concept similar to engineering sciences: well-characterized and standardized modular biological building blocks are reassembled in a systematic and rational manner to generate complex devices and systems with a predicted function. In the past, molecular biological research in combination with intense work in new research areas like systems (...) biology and functional genomics revealed a large inventory of multifaceted modular biological parts that are now in the toolboxes of synthetic biologists. Due to .. (shrink)

A connectionist system that is capable of learning about the spatial structure of a simple world is used for the purposes of synthetic epistemology: the creation and analysis of artificial systems in order to clarify philosophical issues that arise in the explanation of how agents, both natural and artificial, represent the world. In this case, the issues to be clarified focus on the content of representational states that exist prior to a fully objective understanding of a spatial domain. In (...) particular, the criticisms of (Chrisley, 1993) that were raised in (Holland, 1994) are addressed: how can we determine that a system’s spatial representations are more objective than before? And under what conditions (tasks, training regimes, environments) do such increases in objectivity occur? After analysing the results of experiments that attempt to shed light on these questions, the study concludes by comparing and contrasting this work with related research. (shrink)

Based on a nuanced understanding of immersion and sense of presence as two key aesthetic effects that the application of virtual reality to cinema is believed to innovate, this paper develops the concept of synthetic vision as fundamental to understanding the visual experience of VR media, particularly VR documentaries. The concept contends that viewers’ experience in VR is based on two visions that seemingly contradict each other: first, a disembodied vision that transports them to a simulated world, and second, (...) an embodied vision guaranteed by the freedom to control kinesthetic movement and direction of gaze. This serves to advance the idea that immersion and SoP are not unified but rather multifaceted concepts premised on a nuanced understanding of the varying relationships between the technological system of VR, its media content, and its user. For the concept of synthetic vision points to the paradoxical coexistence of viewers’ presence in the virtual world and their structural absence from the world that lays the groundwork for their immersive experience. By classifying three generic categories of contemporary VR documentaries, and by examining the aesthetic and ethical underpinnings VR brings to each of them, I argue that it hinges upon what kind of cinematic conventions and genres are remediated to determine the effective synthesis of the two visions. The varying effects of synthetic vision in the three subgenres of VR documentary stress that immersion and SoP have different political and ethical consequences of media witnessing. In the conclusion, I recapitulate multiple implications that the concept of synthetic vision has in regards to both the studies on VR and the recently flourishing investigation into cinematic VR artifacts. (shrink)

To illustrate dramatically the progress and potential in the field of synthetic biology, one can begin the story with the 2011 winner of the Lasker Clinical Medical Research Award (Youyou 2011). She was an 81-year-old Chinese scientist, Dr. Tu Youyou, who was given an assignment in 1969 by the Chinese government to find a treatment for malaria from among Chinese herbal medicines. She investigated more than 2,000 Chinese herbal preparations, winnowed them down to some 640 possibilities, obtained 380 extracts (...) from about 200 Chinese herbs, and tested them against a mouse model of malaria. She found one extract, of the Artemisia plant, effective in mice, but she could not reproduce the results consistently. So she .. (shrink)

The NeoSynthesis Research Centre (NSRC) was organized to promote sustainable agriculture and resource conservation in the island nation of Sri Lanka. Staffed by people with varied life and cultural backgrounds, NSRC has attempted to develop frameworks or ways of understanding agriculture from more than a single perspective. It is assumed that even a partial understanding of agriculture requires many perspectives because no single set of opinions or discourse based upon a narrow range of life experiences can account for the life (...) processes that capture and process energy through many species,H. Sapiens included. NSRC participants are expected to relate their respective disciplinary paradigms toward a synthetic approach of resource management to be demonstrated under specific environmental and social conditions. Using ecological and energetic perspectives as baseline conceptual frameworks, both scientific and non-scientific descriptions have been incorporated to provide greater understanding of the functioning of Sri Lanka's living communities. Sustainability is not promoted through sound empirical description alone. Broad community participation is required if resource and management is to be modified in any significant way. The notion of sustainability is again translated into a more political and policy language and the forums involved include the public media, administrative and legislative branches of the national government, and the civil service. Is Sri Lanka on a collision course with disaster because of heavy population pressure and irresponsible and unwise landscape management? From experiences over the past 11 years at the NSRC, the steps toward sustainability seem best cast in terms of a discovery and learning process rather than something to be invented in the abstract. (shrink)

The construction of synthetic life might appear to be the natural objective of the emerging discipline of synthetic biology. The situation, though, is not that simple. Plans to synthesize life appeared quite early, at the beginning of the 20th century (Bensaude-Vincent 2009; Deichmann 2009; Fox Keller 2002; Pereto and Catala 2007). Nor can synthetic biology be identified with work on the origin of life. Nevertheless, it is remarkable that a new, more integrated approach to the origin of (...) life appeared exactly when synthetic biology was emerging (Szostak, Bartel, and Luisi 2001).Most synthetic biologists have the more limited ambition of modifying existing organisms by giving them new functionalities. Synthetic .. (shrink)

The SynBioSecurity argument says that synthetic biology introduces new risks of intentional misuse of synthetic pathogens and that, therefore, there is a need for extra regulations and oversight. This paper provides an analysis of the argument, sets forth a new version of it, and identifies three developments that raise biosecurity risks compared to the situation earlier. The developments include a spread of the required know-how, improved availability of the techniques, instruments and biological parts, and new technical possibilities such (...) as “resurrecting” disappeared pathogens. It is first shown that the general argument from SynBioSecurity needs to be qualified and that many improvements to biosecurity have already been implemented, most notably in the United States. Second, I suggest a new strain of the argument: the situation that most branches of synthetic biology fall under the gene technology regulation in the European Union and that this regulation in its current form does not adequately address SynBioSecurity risks together provide a weighty reason to review and possibly refine the legislation as well as the supervisory practices. Ethically speaking, the rise in the relative risk of bioterrorism brings to the fore new extrinsic issues. (shrink)

It has become commonplace to say that with the advent of technologies like synthetic biology the line between artifacts and living organisms, policed by metaphysicians since antiquity, is beginning to blur. But that line began to blur 10,000 years ago when plants and animals were first domesticated; and has been thoroughly blurred at least since agriculture became the dominant human subsistence pattern many millennia ago. Synthetic biology is ultimately only a late and unexceptional offshoot of this prehistoric development. (...) From this perspective, then, synthetic biology is a red herring, distracting us from more thorough philosophical consideration of the most truly revolutionary human practice—agriculture. In the first section of this paper I will make this case with regard to ontology, arguing that synthetic biology crosses no ontological lines that were not crossed already in the Neolithic. In the second section I will construct a parallel case with regard to cognition, arguing that synthetic biology as biological engineering represents no cognitive advance over what was required for domestication and the new agricultural subsistence pattern it grounds. In the final section I will make the case with regard to human existence, arguing that synthetic biology, even if wildly successful, is not in a position to cause significant existential change in what it is to be human over and above the massive existential change caused by the transition to agriculture. I conclude that a longer historical perspective casts new light on some important issues in philosophy of technology and environmental philosophy. (shrink)

Currently, under the law of intellectual property, IP owners may exclude from use or production substances and processes that we would ordinarily consider to be products of nature. This has helped companies monopolize disease genes, and thus diagnostic testing for those diseases, and “biosimilar” products, pharmaceutical materials that mimic biological materials. Extending the current paradigm to the world of synthetic biology and nanotechnology will create further injustices in the delivery of health care to billions of people around the world. (...) As such, I advocate heading this trend off at the pass. Scientists ought to conduct basic research into the building blocks of biology and matter in the open, publishing their results, releasing knowledge into the public domain upstream so that beneficial innovation can be produced without fear of downstream litigation, and so that what ought to remain in the public domain as a matter of right (products of nature) does not become unjustly monopolized. (shrink)

THERE IS A CLEAR DISTINCTION BETWEEN ANALYTIC AND SYNTHETIC SENTENCES IF WE DEFINE AN ANALYTIC SENTENCE AS ONE WHICH ENTAILS A SELF-CONTRADICTION. THE PAPER SHOWS THAT ALTHOUGH THIS DEFINES "ANALYTIC" BY TERMS WHICH ARE THEMSELVES ALSO MODAL TERMS, THESE LATTER TERMS CAN BE EXPLAINED BY DEFINITIONS USING LESS TECHNICAL TERMS AND BY EXAMPLES, IN SUCH A WAY AS TO GIVE "ANALYTIC" AS CLEAR A MEANING AS IS POSSESSED BY MOST OTHER TERMS OF OUR LANGUAGE. THE FACT THAT THERE ARE (...) BORDER-LINE CASES OF ANALYTIC SENTENCES, AND THAT APPARENTLY SOME OBVIOUS CASES OF ANALYTIC SENTENCES TURN OUT TO BE SYNTHETIC IS NO GOOD OBJECTION TO THE CLARITY OF THE DISTINCTION. IF WE DEFINE AN ANALYTIC SENTENCE AS ONE REDUCIBLE TO A TRUTH OF LOGIC BY SUBSTITUTION OF SYNONYMS, THIS DEFINITION PICKS OUT A DIFFERENT CLASS OF SENTENCES AS ANALYTIC, BUT IT ALSO ALLOWS US TO MAKE A CLEAR DISTINCTION BETWEEN THE ANALYTIC AND THE SYNTHETIC. (shrink)

Synthetic biology may be an important source of progress as well as societal and political conflict. Against this backdrop, several technology assessment organizations have been seeking to contribute to timely societal and political opinion-making on synthetic biology. The Rathenau Instituut, based in the Netherlands, is one of these organizations. In 2011, the institute organized a ‘Meeting of Young Minds’: a young people’s debate between ‘future synthetic biologists’ and ‘future politicians’. The former were represented by participants in the (...) international Genetically Engineered Machines competition, the latter by political youth organizations linked to Dutch political parties. The Rathenau Instituut found seven PYOs—including right wing, left wing, Green and Christian groups—willing to commit to an intensive process aimed at formulating a tentative partisan view on synthetic biology and discussing it with fellow PYOs and iGEM participants. Given the minimal amount of available data on how political parties understand synthetic biology, mapping the debate may provide valuable insights. In this article, I aim to provide such a mapping exercise and also to reflect on how and why the Rathenau Instituut organized the event. (shrink)

According to rationalists, synthetic a priori propositions convey new knowledge, whereas analytic propositions are non-informative or vacuous conceptual truths. However, as we argue in this article, each a priori proposition is necessarily true because of its semantic constituents and the way they are combined, and hence can be transformed into its equivalent analytic form. So each synthetic a priori proposition conveys only non-informative conceptual truths like analytic propositions.

This article considers an apparent Achilles heel for Kant’s transcendental idealism, concerning his account of how synthetic a priori knowledge is possible. The problem is that while Kant’s distinctive attempt to explain synthetic a priori knowledge lies at the heart of his transcendental idealism, this explanation appears to face a dilemma: either the explanation generates a problematic regress, or the explanation it offers gives us no reason to favour transcendental idealism over transcendental realism. In the article, I consider (...) G. E. Moore’s version of the problem, which I argue has not yet received an adequate response. Instead, I offer a way out of this dilemma by focusing on the normativity rather than the metaphysics of the mind. (shrink)

I examine the positive and negative features of synthetic biology (‘SynBio’) from a utilitarian ethical perspective. The potential beneficial outcomes from SynBio in the context of medicine are substantial; however it is not presently possible to predict precise outcomes due to the nascent state of the field. Potential negative outcomes from SynBio also exist, including iatrogenesis and bioterrorism; however it is not yet possible to quantify these risks. I argue that the application of a ‘precautionary’ approach to SynBio is (...) ethically fraught, as is the notion that SynBio-associated knowledge ought to be restricted. I conclude that utilitarians ought to support a broadly laissez-faire stance in respect of SynBio. (shrink)

Recent developments in synthetic biology are described and characterized as moving the era of biotechnology into platform technologies. Platform technologies enable rapid and diffuse innovations and simultaneous product development in diffuse markets, often targeting sectors of the economy that have traditionally been thought to have little relationship to one another. In the case of synthetic biology, pharmaceutical and biofuel product development are occurring interactively. But the regulatory and ethical issues associated with these two applications share very little overlap. (...) As such, there is some risk that focus on traditional medical applications, for which the ethical expertise is highly developed, will overshadow the ethical issues that arise in connection with land use and its attendant socioeconomic consequences, especially in the developing world. The 2010 report of the Presidential Commission for the Study of Bioethics exhibits this tendency. (shrink)

Synthetic biology is often understood in terms of the pursuit for well-characterized biological parts to create synthetic wholes. Accordingly, it has typically been conceived of as an engineering dominated and application oriented field. We argue that the relationship of synthetic biology to engineering is far more nuanced than that and involves a sophisticated epistemic dimension, as shown by the recent practice of synthetic modeling. Synthetic models are engineered genetic networks that are implanted in a natural (...) cell environment. Their construction is typically combined with experiments on model organisms as well as mathematical modeling and simulation. What is especially interesting about this combinational modeling practice is that, apart from greater integration between these different epistemic activities, it has also led to the questioning of some central assumptions and notions on which synthetic biology is based. As a result synthetic biology is in the process of becoming more “biology inspired.”. (shrink)

The scientific study of living organisms is permeated by machine and design metaphors. Genes are thought of as the ‘‘blueprint’’ of an organism, organisms are ‘‘reverse engineered’’ to discover their functionality, and living cells are compared to biochemical factories, complete with assembly lines, transport systems, messenger circuits, etc. Although the notion of design is indispensable to think about adaptations, and engineering analogies have considerable heuristic value (e.g., optimality assumptions), we argue they are limited in several important respects. In particular, the (...) analogy with human-made machines falters when we move down to the level of molecular biology and genetics. Living organisms are far more messy and less transparent than human-made machines. Notoriously, evolution is an opportunistic tinkerer, blindly stumbling on ‘‘designs’’ that no sensible engineer would come up with. Despite impressive technological innovation, the prospect of artificially designing new life forms from scratch has proven more difficult than the superficial analogy with ‘‘programming’’ the right ‘‘software’’ would suggest. The idea of applying straightforward engineering approaches to living systems and their genomes— isolating functional components, designing new parts from scratch, recombining and assembling them into novel life forms—pushes the analogy with human artifacts beyond its limits. In the absence of a one-to-one correspondence between genotype and phenotype, there is no straightforward way to implement novel biological functions and design new life forms. Both the developmental complexity of gene expression and the multifarious interactions of genes and environments are serious obstacles for ‘‘engineering’’ a particular phenotype. The problem of reverse-engineering a desired phenotype to its genetic ‘‘instructions’’ is probably intractable for any but the most simple phenotypes. Recent developments in the field of bio-engineering and synthetic biology reflect these limitations. Instead of genetically engineering a desired trait from scratch, as the machine/engineering metaphor promises, researchers are making greater strides by co-opting natural selection to ‘‘search’’ for a suitable genotype, or by borrowing and recombining genetic material from extant life forms. (shrink)

I try to show that there is much sap (synthetic a priori) knowledge although one may not find many, or even any, sap true statements in most natural languages. Reasons are given for the difficulty of expressing sap truths in natural languages, but it is argued that these are not necessary features of language as such. There are, then, sap true statements in some possible languages.Admission of the sap gives one a way of distinguishing logical from metaphysical possiblity. Something (...) is metaphysically impossible just in case it is a sap truth that it is impossible. I argue that the realm of logically possible entities is vastly larger than the realm of metaphysically possible entities.My.defence of the sap begins with a partial defence of the analytic/synthetic distinction. In particular, I attack the intentionality circle argument,Quine's indeterminacy thesis and some applications of the Kripke/Putnam theory of meaning for natural kind terms. Without being a conclusive defence of the analytic/synthetic distinction, this section makes the defence of the sap more secure. Arguments are then mounted in direct defence of the sap by showing that the purported reduction of sap truths to analytic truths is mistaken. Examples are adduced to show that, even where expressions of natural language fail, one can stipulate usage in ways that allow expression of sap truths. I then consider and reply to various objections, giving an example of the sort of meaning theory which illegitimately legislates the analyticity of any purported sap true statement. (shrink)

In twentieth-century Kant scholarship, few have provided an account of the analytic-synthetic distinction and of the problem of the synthetic a priori that takes into consideration the views of Kant's idealist successors such as Maimon, Fichte, Schelling, and Hegel. I first explain how Kant formulates the analytic-synthetic distinction in terms of the determinate-indeterminate distinction, which, in turn, is based on the distinction between general and transcendental logic. Kant's problem of the synthetic a priori , then, is (...) the problem of showing how the logical forms of judgment can be employed determinately (and not merely indeterminately). I then show that Maimon also formulates the distinction and the problem in the same way, and that his interpretation will shape how Fichte, Schelling, and Hegel each construe and address Kant's question, How are synthetic judgments possible a priori ? (shrink)

Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie (...) into two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge-making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems. (shrink)