Noninvasive brain stimulation provides a promising approach for the treatment of neuropsychiatric conditions. Despite the increasing research on the facilitatory effects of this kind of stimulation on the cognitive processes, the majority of the studies have used the standard stimulation approaches such as the transcranial direct current stimulation and the conventional repetitive transcranial magnetic stimulation which seem to be limited in robustness and the duration of the transient effects. However, a recent specialized type of rTMS, theta-burst stimulation, patterned to mimic (...) the natural cross-frequency coupling of the human brain, may induce robust and longer-lasting effects on cortical activity. Here, we aimed to investigate the effects of the intermittent TBS, a facilitatory form of TBS, over the right DLPFC, a brain area implicated in higher-order cognitive processes, on visuospatial working memory performance. Therefore, iTBS was applied over either the rDLPFC or the vertex of 24 healthy participants, in two separate sessions. We assessed VSWM performance using 2-back and 4-back visuospatial tasks before iTBS, and after the iTBS. Our results indicate that the iTBS over the rDLPFC significantly enhanced VSWM performance in the 2-back task, as measured by the discriminability index and the reaction time. However, the 4-back task performance was not significantly modulated by iTBS. These findings demonstrate that the rDLPFC plays a critical role in VSWM and that iTBS is a safe and effective approach for investigating the causal role of the specific brain areas. (shrink)

Social anxiety is associated with attentional bias and working memory for emotional stimuli; however, the ways in which social anxiety affects cognitive functions involving non-emotional stimuli remains unclear. The present study focused on the role of attentional networks and visuospatial working memory capacity for non-emotional stimuli in the context of social anxiety. One hundred and seventeen undergraduates completed questionnaires on social anxiety. They then performed an attentional network test and a change detection task to measure visuospatial WMC. Orienting (...) network and visuospatial WMC were positively correlated with social anxiety. A multiple regression analysis showed significant positive associations of alerting, orienting, and visuospatial WMC with social anxiety. Alerting, orienting networks, and high visuospatial WMC for non-emotional stimuli may predict degree of social anxiety. (shrink)

Poor sleep quality negatively affects memory performance, and working memory in particular. We investigated sleep habits related to sleep quality including sleep duration, daytime nap duration, nap frequency, and dream content recall frequency (DCRF). Declarative working memory can be subdivided into verbal working memory (VWM) and visuospatial working memory (VSWM). We hypothesized that sleep habits would have different effects on VWM and VSWM. To our knowledge, our study is the first to investigate differences between VWM (...) and VSWM related to daytime nap duration, nap frequency, and DCRF. Furthermore, we tested the hypothesis that the effects of duration and frequency of daytime naps and DCRF on VWM and VSWM differed according to sex. We assessed 779 healthy right-handed individuals (434 males and 345 females; mean age: 20.7 ± 1.8 years) using a digit span forward and backward VWM task, a forward and backward VSWM task, and sleep habits scales. A correlation analysis was used to test the relationships between VWM capacity (VWMC) and VSWM capacity (VSWMC) scores and sleep duration, nap duration, nap frequency, and DCRF. Furthermore, multiple regression analyses were conducted to identify factors associated with VWMC and VSWMC scores and to identify sex-related differences. We found significant positive correlations between VSWMC and nap duration and DCRF, and between VWMC and sleep duration in all subjects. Furthermore, we found that working memory capacity (WMC) was positively correlated with nap duration in males and with sleep duration in females, and DCRF was positively correlated with VSWMC in females. Our finding of sex-related differences in the effects of sleep habits on WMC has not been reported previously. The associations between WMC and sleep habits differed according to sex because of differences in the underlying neural correlates of VWM and VSWM, and effectiveness of the sleep habits in males and females. (shrink)

The visuospatial system integrates inner and outer functional processes, organizing spatial, temporal, and social interactions between the brain, body, and environment. These processes involve sensorimotor networks like the eye–hand circuit, which is especially important to primates, given their reliance on vision and touch as primary sensory modalities and the use of the hands in social and environmental interactions. At the same time, visuospatial cognition is intimately connected with memory, self-awareness, and simulation capacity. In the present article, we review issues (...) associated with investigating visuospatial integration in extinct human groups through the use of anatomical and behavioral data gleaned from the paleontological and archaeological records. In modern humans, paleoneurological analyses have demonstrated noticeable and unique morphological changes in the parietal cortex, a region crucial to visuospatial management. Archaeological data provides information on hand–tool interaction, the spatial behavior of past populations, and their interaction with the environment. Visuospatial integration may represent a critical bridge between extended cognition, self-awareness, and social perception. As such, visuospatial functions are relevant to the hypothesis that human evolution is characterized by changes in brain–body–environment interactions and relations, which enhance integration between internal and external cognitive components through neural plasticity and the development of a specialized embodiment capacity. We therefore advocate the investigation of visuospatial functions in past populations through the paleoneurological study of anatomical elements and archaeological analysis of visuospatial behaviors. (shrink)

Sign language interpreting is a cognitively challenging task performed mostly by second language learners. SLI students must first gain language fluency in a new visuospatial modality and then move between spoken and signed modalities as they interpret. As a result, many students plateau before reaching working fluency, and SLI training program drop-out rates are high. However, we know little about the requisite skills to become a successful interpreter: the few existing studies investigating SLI aptitude in terms of linguistic and cognitive (...) skills lack baseline measures. Here we report a 3-year exploratory longitudinal skills assessments study with British Sign Language -English SLI students at two universities. Our aims were two-fold: first, to better understand the prerequisite skills that lead to successful SLI outcomes; second, to better understand how signing and interpreting skills impact other aspects of cognition. A battery of tasks was completed at four time points to assess skills, including but not limited to: multimodal and unimodal working memory, 2-dimensional and 3-dimensional mental rotation, and English comprehension. Dependent measures were BSL and SLI course grades, BSL reproduction tests, and consecutive SLI tasks. Results reveal that initial BSL proficiency and 2D-MR were associated with selection for the degree program, while visuospatial working memory was linked to continuing with the program. 3D-MR improved throughout the degree, alongside some limited gains in auditory, visuospatial, and multimodal working memory tasks. Visuospatial working memory and MR were the skills closest associated with BSL and SLI outcomes, particularly those tasks involving sign language production, thus, highlighting the importance of cognition related to the visuospatial modality. These preliminary data will inform SLI training programs, from applicant selection to curriculum design. (shrink)

Although working memory and information processing speed impairments in multiple sclerosis have been widely investigated, several questions, regarding the nature of these impairments and their relationship, remain unclear. The aim of this short communication article is to present an overview of our recent research findings regarding the characteristics of WM impairment in MS patients and, more precisely, the degree of impairment observed in each WM’s component, i.e., phonological loop, visuospatial sketchpad, central executive, and episodic buffer and the relationship between (...) IPS and each of the four WM components, in an attempt to expand the existing rather narrow understanding of the interconnection between reduced IPS and WM impairment. Two studies of our research team are presented here and their findings are briefly discussed, highlighting the importance of further research on a specific component, namely the episodic buffer component among MS patients. (shrink)

Way-finding (WF) is the ability to move around efficiently and find the way from a starting point to a destination. It is a component of spatial navigation, a coordinate and goal-directed movement of one’s self through the environment. In the present study, the relationship between WF tasks (route tracing and shortcut finding) and individual factors were explored with the hypothesis that WF tasks would be predicted by different types of cognitive, affective, motivational variables and personality factors. A group of 116 (...) university students (88 F.) was conducted along a route in a virtual environment and then asked first to trace the same route again, and then to find a shortcut between the start and end points. Several instruments assessing visuospatial working memory, mental rotation ability, self-efficacy, spatial anxiety, positive attitude to exploring, and personality traits were administered. The results showed that a latent spatial ability factor (measured with the visuospatial working memory and mental rotations tests) - controlled for gender - predicted route-tracing performance, while self-report measures of anxiety, efficacy, and pleasure in exploring, and some personality traits were more likely to predict shortcut-finding performance. We concluded that both personality and cognitive abilities affect WF performance, but differently, depending on the requirements of the task. (shrink)

This study aimed to explore the influence of the visuospatial active working memory sub-components on early math skills in young children, followed longitudinally along the first two years of primary school. We administered tests investigating visual active working memory (jigsaw puzzle), spatial active working memory (backward Corsi), and math tasks to 43 children at the beginning of first grade (T1), at the end of first grade (T2), and at the end of second grade (T3). Math tasks were (...) select according to the children’s age and their levels of formal education: the “Battery for the evaluation of numerical intelligence from 4 to 6 years of age” (BIN 4–6) at T1 to test early numerical competence and the “Test for the evaluation of calculating and problem-solving abilities” (AC-MT 6–11) to test math skills at T2 and T3. Three regression models, in which the predictors were identified through a forward selection based on the use of the Bayesian information criterion (BIC) index, were performed to study the relationship between visual and spatial working memory and math ability at the three points in time. The results show that spatial working memory influences early numerical performance at T1, while early numerical performance is the unique predic-tor of math performance at T2. At the end of the second grade, the regression model reveals a relationship between math performance and both visual and spatial working memory and the attenuation of the importance of domain-specific predictors. The study depicts the dif-ferent implications of visual and spatial working memory predictors over the children’s de-velopment periods and brings additional evidence to the debate on the relationship between visuospatial working memory and math ability in young children. (shrink)

This paper addresses relations between memory and imagery in expert sport in relation to visual or visuospatial perspective. Imagining, remembering, and moving potentially interact via related forms of episodic simulation, whether future- or past-directed. Sometimes I see myself engaged in action: many experts report switching between such external visual perspectives and an internal, 'own-eyes', or field perspective on their past or possible performance. Perspective in retrieval and in imagery may be flexible and multiple. I raise a range of topics (...) for empirical research on perspective and visualization. (shrink)

Sometimes I remember my past experiences from an ‘observer’ perspective, seeing myself in the remembered scene. This paper analyses the distinction in personal memory between such external observer visuospatial perspectives and ‘field’ perspectives, in which I experience the remembered actions and events as from my original point of view. It argues that Richard Wollheim’s related distinction between centred and acentred memory fails to capture the key phenomena, and criticizes Wollheim’s reasons for doubting that observer ‘memories’ are genuine personal (...) memories. Since field perspectives in personal memory are also likely to be the product of constructive processes, we should reject the common assumption that such constructive processes inevitably bring distortion and error. Yet field perspectives tend to be treated as privileged also in the domains of memory for skilled movement, and memory for trauma. In each case, it is argued that visuospatial perspective in personal memory should be distinguished from other kinds of perspective such as kinesthetic perspective and emotional perspective. (shrink)

BackgroundNeuropsychological profile of Indian Duchenne muscular dystrophy subjects remains unidentified and needs to be evaluated.MethodsA total of 69 DMD and 66 controls were subjected to detailed intelligence and neuropsychological assessment. The factor indexes were derived from various components of Malin’s Intelligence Scale for Indian Children and Rey Auditory Verbal Learning Test.ResultsPoor verbal and visual memory profiles were demonstrated by DMDs, which include RAVLT-immediate recall, RAVLT-delayed recall, Rey–Osterrieth complex figure test -IR, and RCFT-DR. RAVLT-memory efficiency index demonstrated poor verbal (...) memory efficiency. Significant differences in the functioning of working memory axis [RAVLT T1, recency T1, Digit Span Backward ] were observed along with reduced performance in visuomotor coordination, visuospatial, and visual recognition abilities. Block designing efficiency index and attention fraction showed a normal performance in DMD kids.ConclusionWorking memory deficits were found to be the crucial element of cognitive functioning in DMD cases. Working memory interventions may be beneficial to improve the neuropsychological profile in DMD. (shrink)

Four experiments assessed the relative involvement of different working memory components in two types of reasoning tasks: propositional and spatial reasoning. Using the secondary-task methodology, visual, central-executive, and phonological loads were realised. Although the involvement of visuospatial resources in propositional reasoning has traditionally been considered to be small, an overall analysis of the present data suggests an alternative account. A theoretical analysis of the pattern of results in terms of Evans' (1984, 1989) twostage theory of reasoning is proposed and (...) tested in Experiments 3 and 4, in which direct evidence for the alternative account was obtained: significant disruption of propositional reasoning by a concurrent spatial load. (shrink)

In the prior studies, the significance of working memory is linked to language acquisition which helped in understanding these disorders better (Wen, & Li, 2019). However, there is one component that is not being taken into consideration with Second Language Acquisition (SLA) (Choi, 2019). This study collected data from 122 adolescents and young adults (Female = 61, Male = 61) in the age range 15–22 years. Using four subtests of David’s Battery of Differential Abilities (DBDA), measures of VSSP and (...) verbal ability were measured. Multiple regression analysis was carried out between the measures of VSSP and verbal ability. The results showed promise and the measures of VSSP were found to be a positive predictor of second language comprehension in the current sample. Whereas, no gender differences were observed with regard to verbal ability. With the supporting literature, this study evidently provided insights into the overall relationship. (shrink)

Exposure to environmental contextual changes, such as those occurring after an earthquake, requires individuals to learn novel routes around their environment, landmarks and spatial layout. In this study, we aimed to uncover whether contextual changes that occurred after the 2009 L’Aquila earthquake affected topographic memory in exposed survivors. We hypothesized that individuals exposed to environmental changes—individuals living in L’Aquila before, during and after the earthquake (hereafter called exposed participants, EPs)—improved their topographic memory skills compared with non-exposed participants (NEPs) (...) who moved to L’Aquila after the earthquake, as only EPs had to modify their previous cognitive map of L’Aquila. We also hypothesized that memory improvement was selective for the navigational space and did not generalize across other spatial and verbal domains. To test these hypotheses, we compared the topographic and spatial memory skills of 56 EPs without post-traumatic stress disorder (PTSD) symptoms to the skills of 47 NEPs using the Walking Corsi Test (WalCT; memory test in the navigational space) and the Corsi Block-Tapping Test (CBT; visuospatial memory test in the reaching space); EPs and NEPs were matched for gender, education and general navigational skills. A sub-group of participants also underwent the Rey-Auditory Verbal Learning Test (RAVLT; verbal memory test). The results showed that only EPs had better performances on topographic learning (TL) assessed using the WalCT rather than spatial learning assessed by the CBT. This outcome suggests the possibility that EPs specifically improved topographic memory. This effect may be due to continuous exposure to environmental changes that have required individuals to learn novel paths within the city and integrate novel information, such as “new towns,” into their pre-existing mental representation of the city. Implications and limitations of the study are discussed. (shrink)

Memory perspectives on past events allegedly take one of two shapes. In field memories, we recall episodes from a first-person point of view, while in observer memories, we look at a past scene from a third-person perspective. But this mere visuospatial dichotomy faces several practical and conceptual challenges. First, this binary distinction is not exhaustive. Second, this characterization insufficiently accounts for the phenomenology of observer memories. Third, the focus on the visual aspect of memory perspective neglects emotional, agential, (...) and self-related social aspects. Fourth, the focus on the time of recall neglects the fact that visual, emotional, agential, and social aspects of perspective can also be dissociated in the original experience. In this chapter, we move away from the standard visual dichotomy. Instead, we propose that memory perspective is better understood along four lines: visual, agential, emotional, and social. Drawing on empirical research, we argue that these dimensions predict a disposition to recall a past event based on the present situation of the memorizer. This account supports seeing episodic memory as a natural kind, supported by scenario construction mechanisms and minimal memory traces. By remapping the classic distinction between field and observer perspectives along four dimensions, our proposal provides explanatory advantages and secures practical gains by enabling testable hypotheses. (shrink)

We investigated the feasibility of a short intervention using the Method of Loci, a well-known visuospatial mnemonic, to improve episodic memory recall performance in schizophrenia. The MoL training protocol comprised encoding and recall of two lists of items, a training session and practice with MoL. Then, participants had the opportunity to put into practice the newly learned MoL and were instructed to encode and recall two new lists of items using. This approach was first validated with healthy individuals. Subsequently, (...) five individuals with schizophrenia completed the protocol. Improvement in healthy individuals was observed for the word list. No significant memory improvement was denoted in the schizophrenia group, possibly due to participants' difficulties using the method efficiently and due to fatigue. The MoL seems to require episodic memory, working memory monitoring and executive functions, making it suboptimal for a population with impairments in all those domains. Future research should examine the use of other strategies, better suited for individuals with cognitive impairments like those found in schizophrenia. (shrink)

Glenberg focuses on conceptualizations that change from moment to moment, yet he dismisses the concept of working memory (sect. 4.3), which offers an account of temporary storage and on-line cognition. This commentary questions whether Glenberg's account adequately caters for observations of consistent data patterns in temporary storage of verbal and visuospatial information in healthy adults and in brain-damaged patients with deficits in temporary retention.

Dissociative symptoms are notorious for their enigmatic, disparate nature encompassing excessive daydreaming, memory problems, absentmindedness, and impairments and discontinuities in perceptions of the self, identity, and the environment. Recent studies (e.g., Koffel & Watson, 2009) have linked dissociative symptoms to vivid dreaming, nightmares, and objective sleep parameters (e.g., lengthening of REM sleep) for discussion, see (Van der Kloet et al., 2013). Germane to this link between dissociative symptomology and sleep, is the idea that in dissociative individuals, the waking state (...) as compared to REM sleep may be marked by an increase in “fluid” and hyperassociative thinking. Against this background, we invited contributions in the following areas: 1) a progressive and enduring de-differentation of wake and dream states of consciousness eventually results in schizophrenia (Llewellyn, 2011); a lesser degree of de-differentiation may have implications for dissociative symptoms; 2) sleep disturbances are not only linked to dissociation but to memory fragmentation also, further fuelling both dissociation and other manifestations of psychopathology; 3) sleep, memory and psychopathologies have complex interlinkages. Our summary below, relates the contributions to our topic to these areas. The contributing articles also give a comprehensive overview on current directions and challenges in these research fields.First, Soffer-Dudek elucidates why heightened sleep experiences (vivid dreams, nightmares, hypnagogic hallucinations) might be particularly associated with psychopathology. She explains how various psychopathologies may represent de-differentiation of the waking and dreaming states through intrusions of wake-like consciousness into sleep and dream-like cognition into wake. With regard to de-differentiation, she discusses theories of transliminality (‘thin boundaries between consciousness states’) and dissociation as potential mechanisms. Lucid dreaming is a hybrid state where wake-like cognition suffuses REM sleep/dreaming (Voss et al. 2009). Mota and colleagues compared the spontaneous occurrence of lucid dreaming in patients with psychotic symptoms (25 with schizophrenia and 20 with bipolar disorder) and 28 non-psychotic subjects. They found lucid dreaming was associated with psychosis- giving some support to the hypothesis of a link between state de-differentiation and psychopathology. In a methodological note, Ribeiro et al, having studied the prevalence of lucid dreaming using two questionnaires, show that the type of methodology used in lucid dreaming studies may have an effect upon their findings. Poerio et al state that both research and theory points to dissociation being engendered by the intrusion of dream-like mentation into waking consciousness. To extend this idea they examine the role of sleep and daydreaming as potentiating states for subsequent dissociation in depersonalization/derealization disorder (DDD). They show the occurrence and content of daydreams may act as potentiating states for heightened, in the moment, dissociation. Sleep paralysis is a dissociated state where a heightened level of wake-like alertness coexists with muscle atonia. Rodrigez de Sa and Mota-Rolim take a broad interdisciplinary perspective on sleep paralysis through reviewing its occurrence in Brazilian folklore by exploring the “Pisadeira” with a sleep science approach and link this with the field of history and art.There is now substantial evidence that active memory processing continues during sleep (see, for example, Rasch and Born (2013)) and dreaming may be involved (Llewellyn, 2013). De-differentiation of the wake, sleep and dream states would disrupt this memory processing fuelling dissociation and other psychopathologies. Horton presents an overview of discontinuity of consciousness in both wake and sleep, focusing on the processes of sleep-dependent memory consolidation and fragmentation. Nakagawa et al focus specifically on working memory and the relation with sleep. With their article, they are the first to investigate differences between verbal working memory (VWM) and visuospatial working memory (VSWM) related to daytime nap duration, nap frequency, and dream content recall frequency (DCRF). They discuss sex-related differences in the effects of sleep habits on VMW and VSWM and ascribe this to differences in underlying neural correlates, and effectiveness of sleep habits in males and females. Rosales-Lagarde and colleagues related to emotional memory by designing an extended International Affective Picture System (IAPS) instrument to measure bizarreness and show some interesting age and gender disparities. Finally, several authors took a developmental approach through focusing on sleep, memory and psychopathology in adolescents. Wang and colleagues show the relation between children and adolescents’ mental health and sleep problems in a 10-year longitudinal trial, and find anxiety, depression, attention problems and aggressive behaviour during childhood to be important predictors for later sleep problems. Importantly, sleep problems are also predictive of behavioural difficulties later in life. Nader, Murkar, and Smith investigated changes in sleep in adolescents between 12 and 19 years old following procedural task training and found that contrary to earlier work, there were no changes in sleep spindle density. Interestingly, participants who successfully learned the task showed no changes in their sleep stage proportions, but participants who were not successful showed a decrease in the proportion of Stage 2 and increases in both SWS and REM sleep, which is in line with the two stage model of sleep and memory by Smith et al. (2004).The self and the world during dreaming differ. The perceived world during waking depends on making sense of external sensory input, which engenders a strong sense of external reality in which the ‘self and its inner-world’ exists. Self-organizing during waking and dreaming enables integration of the self and the world in both states. It is noteworthy, that within this research topic so many novel themes have emerged and new questions and speculations have been posed with regards to relations among unusual sleep experiences – specifically lucid dreaming -, dissociation, psychosis, and memory. It brings together a richness of research by combining fields that originally have worked in isolation from each other. (shrink)

The Test Your Memory is a brief self-administered, cognitive screening test, currently used in several settings. It requires minimal administrator supervision and the computation of the final test score takes approximately 2 min. We assessed the discrimination ability of the Italian version of the TYM in detecting Mild Cognitive Impairment in clinical setting. TYM-I was administered to 94 MCI patients and 134 healthy controls. The clinical diagnosis of MCI was considered as the gold standard. An extended formal neuropsychological test (...) battery was used to define MCI subtypes. Receiver Operating Characteristic analyses were conducted to find the optimal cut-off and measure discrimination ability of TYM-I in detecting MCI. TYM-I had a similar area under the curve point estimate as Mini Mental State Examination. A TYM-I score lower or equal to 36 was found to be optimal cut off to detect MCI. The TYM-I showed the highest discrimination ability among individuals aged more than 70 and high educational level. The amnestic MCI subtype patients, compared to non-amnestic MCI patients, had worse performance in recall, orientation and visuospatial abilities TYM-I subscores. The TYM-I is a valid screening test in detecting cognitive dysfunction, easily carried out in clinical practice. The TYM-I subscores may allow to identify amnestic and non-amnestic MCI subtypes. (shrink)

Brain-computer interfaces are communication bridges between a human brain and external world, enabling humans to interact with their environment without muscle intervention. Their functionality, therefore, depends on both the BCI system and the cognitive capacities of the user. Motor-imagery BCIs rely on the users’ mental imagination of body movements. However, not all users have the ability to sufficiently modulate their brain activity for control of a MI-BCI; a problem known as BCI illiteracy or inefficiency. The underlying mechanism of this phenomenon (...) and the cause of such difference among users is yet not fully understood. In this study, we investigated the impact of several cognitive and psychological measures on MI-BCI performance. Fifty-five novice BCI-users participated in a left- versus right-hand motor imagery task. In addition to their BCI classification error rate and demographics, psychological measures including personality factors, affinity for technology, and motivation during the experiment, as well as cognitive measures including visuospatial memory and spatial ability and Vividness of Visual Imagery were collected. Factors that were found to have a significant impact on MI-BCI performance were Vividness of Visual Imagery, and the personality factors of orderliness and autonomy. These findings shed light on individual traits that lead to difficulty in BCI operation and hence can help with early prediction of inefficiency among users to optimize training for them. (shrink)

Eye-tracking technology has become a powerful tool for biomedical-related applications due to its simplicity of operation and low requirements on patient language skills. This study aims to use the machine-learning models and deep-learning networks to identify key features of eye movements in Alzheimer's Disease (AD) under specific visual tasks, thereby facilitating computer-aided diagnosis of AD. Firstly, a three-dimensional (3D) visuospatial memory task is designed to provide participants with visual stimuli while their eye-movement data are recorded and used to build (...) an eye-tracking dataset. Then, we propose a novel deep-learning-based model for identifying patients with Alzheimer's Disease (PwAD) and healthy controls (HCs) based on the collected eye-movement data. The proposed model utilizes a nested autoencoder network to extract the eye-movement features from the generated fixation heatmaps and a weight adaptive network layer for the feature fusion, which can preserve as much useful information as possible for the final binary classification. To fully verify the performance of the proposed model, we also design two types of models based on traditional machine-learning and typical deep-learning for comparison. Furthermore, we have also done ablation experiments to verify the effectiveness of each module of the proposed network. Finally, these models are evaluated by four-fold cross-validation on the built eye-tracking dataset. The proposed model shows 85% average accuracy in AD recognition, outperforming machine-learning methods and other typical deep-learning networks. (shrink)

Cognitive decline is common in Parkinson’s disease (PD), and precise cognitive assessment is important for diagnosis, prognosis, and treatment. To date, there are no studies in PD investigating cultural bias on neuropsychological tests. Clinical practice in multicultural societies such as Toronto Canada, where nearly half of the population is comprised of first generation immigrants, presents important challenges as most neuropsychological tools were developed in Anglosphere cultures (e.g., USA, UK) and normed in more homogeneous groups. We examine total scores and rates (...) of deficits on tests of visuoperceptual/visuospatial, attention, memory, and executive functions in Canadians with PD born in Anglosphere countries (n = 248) versus in Canadians with PD born in other regions (International group; n = 167). The International group shows lower scores and greater rates of deficits on all visuoperceptual and some executive function tasks, but not on attention or memory measures. These biases are not explained by demographic and clinical variables as groups were comparable. Age at immigration, years in Canada, and English proficiency also do not account for the observed biases. In contrast, group differences are strongly mediated by the Historical Index of Human Development of the participants’ country of birth, which reflects economic, health, and educational potential of a country at the time of birth. In sum, our findings demonstrate lasting biases on neuropsychological tests despite significant exposure to, and participation in, Canadian culture. These biases are most striking on visuoperceptual measures and non-verbal executive tasks which many clinicians still considered to be “culture-fair” despite the growing evidence from the field of cross-cultural neuropsychology to the contrary. Our findings also illustrate that socio-development context captures important aspects of culture that relate to cognition, and have important implications for clinical practice. (shrink)

Analyzing navigational abilities and related aspects in individuals with Down syndrome (DS) is of considerable interest because of its relevance to everyday life. This study investigates path learning, the conditions favoring it, and the cognitive abilities involved. A group of 30 adults with DS and 32 typically-developing (TD) children matched on receptive vocabulary were shown a 4 × 4 Floor Matrix and asked to repeat increasingly long sequences of steps by walking on the grid. The sequences were presented under two (...) learning conditions, one called Oral instructions (participants received verbal instructions such as “turn right” or “turn left”), the other Observation (participants watched the experimenter's moves). Participants were also assessed on verbal and visuospatial cognitive measures. The results showed a similarly better performance in both groups when the Floor Matrix task was administered in the Observation as opposed to the Oral instructions condition. As for the relation with cognitive abilities, in the Floor Matrix task in the Oral instructions condition, individuals with DS showed an effect of both verbal and visuospatial abilities, which was only positive for verbal ability. The effect of verbal and visuospatial abilities was negligible in the TD group. In the Observation condition, performance was predicted by sequential working memory in both groups. Overall, these results shed light on path learning in individuals with DS, showing that they benefited from the Observation condition, and that the involvement of their cognitive abilities depended on the learning condition. (shrink)

There are problems with both the theoretical logic and the interpretation of data in Christie and Barresi's interesting article. The general pattern of results is easily incorporated into an information-processing framework compatible with Dennett's analysis. In particular, different aspects of the illusory motion event are queried at different times and these aspects are not in conflict, so no revision of conscious content is necessary. Second, too much interpretive weight is placed on an anomalous pair of data points that do not (...) seem fully interpretable within the author's framework and are probably susceptible to one of several alternative interpretations proposed here, though further investigation is necessary. (shrink)

Durgin's (2002) commentary on our article provides us with an opportunity to look more closely at the relationship between information processing and consciousness. In our article we contrasted the information processing approach to interpreting our data, with our own 'scientific' approach to consciousness. However, we should point out that, on our view, information processing as a methodology is not by itself in conflict with the scientific study of consciousness - indeed, we have adopted this very methodology in our experiments, which (...) we purport to use to investigate consciousness. Furthermore, Durgin's own review of the history of research on metacontrast (Lachter & Durgin, 1999) shows that some researchers investigating metacontrast also thought that they were in the business of evaluating the role of consciousness in accounting for their effects. Yet, there is no doubt that metacontrast research is a paradigm case of research generated from an information processing perspective. So, prima facie, investigating consciousness and using information processing methodology are compatible. (shrink)

We review evidence from neuropsychological studies of patients with damage to the cerebellum that suggests cerebellar involvement in four general categories of cognition: (1) speech and language; (2) temporal processing; (3) implicit learning and memory; (4) visuospatial processing and attention. A relatively strong case can be made for cerebellar contributions to language (including speech perception, lexical retrieval, and working memory) and to temporal processing. However, the evidence concerning cerebellar involvement in non-motor implicit learning and visuospatial processing is more (...) equivocal. We argue that cerebellar contributions to cognition are computationally plausible, given its reciprocal connectivity with the cerebral cortex, and suggest that this function of the cerebellum may be an example of an evolutionary process by which mechanisms originally evolved for one function (in this case, motor control) are adapted to other functions (cognition). (shrink)

Integrative and naturalistic philosophy of mind can both learn from and contribute to the contemporary cognitive sciences of dreaming. Two related phenomena concerning self-representation in dreams demonstrate the need to bring disparate fields together. In most dreams, the protagonist or dream self who experiences and actively participates in dream events is or represents the dreamer: but in an intriguing minority of cases, self-representation in dreams is displaced, disrupted, or even absent. Working from dream reports in established databanks, we examine two (...) key forms of polymorphism of self-representation: dreams in which I take an external visuospatial perspective on myself, and those in which I take someone else's perspective on events. In remembering my past experiences or imagining future or possible experiences when awake, I sometimes see myself from an external or 'observer' perspective. By relating the issue of perspective in dreams to established research traditions in the study of memory and imagery, and noting the flexibility of perspective in dreams, we identify new lines of enquiry. In other dreams, the dreamer does not appear to figure at all, and the first person perspective on dream events is occupied by someone else, some other person or character. We call these puzzling cases 'vicarious dreams' and assess some potential ways to make sense of them. Questions about self-representation and perspectives in dreams are intriguing in their own right and pose empirical and conceptual problems about the nature of self-representation with implications beyond the case of dreaming. (shrink)

Gil R, Arroyo-Anllo EM, Ingrand P, Gil M, Neau JP, Ornon C, Bonnaud V. Self-consciousness and Alzheimer’s disease. Acta Neurol Scand 2001: 104: 296–300. # Munksgaard 2001. Objectives – To propose a neuropsychological study of the various aspects of self-consciousness (SC) in Alzheimer’s disease. Methods – Forty-five patients with probable mild or moderate AD were included in the study. Severity of their dementia was assessed by the Mini Mental State (MMS). Fourteen questions were prepared to evaluate SC. Results – No (...) significant correlations were found between SC score and educational level, age, and duration of disease. A significant correlation was found between SC score and the severity of dementia, whereas frontal disturbances were just short of the significance threshold. The various aspects of SC were not impaired to the same degree. The most disturbed ones were awareness of cognitive deficiencies, moral judgements and prospective memory. The least disturbed aspects were awareness of identity and of mental representation of the body. Items relating to anosognosia and moral judgements were significantly correlated with the MMS score, whereas affective state, body representation disorders, prospective memory, and capacities for introspection were not related to the severity of the dementia. Consciousness of identity was sound, regardless of MMS score. Conclusions – AD clearly induces an heterogeneous impairment of SC. SC requires a convergence of many neural networks. In AD, neuronal alterations involve many cortical areas and information sent to the associative frontal cortex from memory, language and visuospatial areas is lacking or disturbed. Thus, the sequential order of successive stimuli cannot be maintained by the heteromodal associative cortex (dorsal convexity of the prefrontal cortex), and the supramodal associative cortex (located rostrally in the frontal lobes) is unable to provide reliable monitoring and assessment of simultaneous neural cognitive networks carrying insufficient and inadequate input. The core deficiency in AD patients might be impaired SC equated with the disability to maintain sequential and simultaneous ‘‘attention to life’’. The Self-Consciousness Questionnaire, a clinical scale providing multidimensional measurement, indicates that different aspects of consciousness are not correlated with overall cognitive deficiency as determined by the MMSE. (shrink)

BackgroundRecently, considerable research has been conducted to study the effects of traditional Chinese exercises on cognitive function in older adults with MCI. We completed a comprehensive systematic review and meta-analysis to assess the efficacy of TCEs on cognitive function in this population.MethodsA search strategy based on the PICOS principle was used to find the literatures in the databases of PubMed, Web of Science, MEDLINE, SPORT-Discus, PsycINFO, Cochrane Central Register of Controlled Trials, Ovid. The quality and risk of bias in the (...) studies were independently assessed by two researchers.ResultsNine trials with 1,290 participants were included. The effect size of TCEs on global cognitive function was small when compared to the active control and was moderate compared to the inactive control; statistically significant effects were also found for short-term memory, long-term memory, shifting, language ability, visuospatial perception.ConclusionThis meta-analysis provides clinicians with moderate evidence to recommend that TCEs hold potential to enhance both global cognitive function and multiple domains of cognitive function, which, however, needs to be confirmed and further examined in futures studies. The results of this work provide critical knowledge for the design of future studies implementing TCEs as well as its clinical practice. Future RCTs with rigorous designs are needed to help obtain more definitive conclusions on the effects of TCEs on cognitive function in older adults with MCI. (shrink)