Antibiotic use triggers evolutionary and ecological responses from bacteria, leading to antibiotic resistance and harmful patient outcomes. Two complementary strategies support long-term antibiotic effectiveness: conservation of existing therapies and production of novel antibiotics. Conservation encompasses infection control, antibiotic stewardship, and other public health interventions to prevent infection, which reduce antibiotic demand. Production of new antibiotics allows physicians to replace existing drugs rendered less effective by resistance.In recent years, physicians and policymakers have raised concerns about the pipeline for new antibiotics, pointing (...) to a decline in the number of antibiotics approved since the 1980s. This trend has been attributed to high research and development costs, low reimbursement for antibiotics, and regulatory standards for review and approval. Professional societies and researchers around the world have called for renewed emphasis on antimicrobial stewardship, while also supporting antibiotic research and development through grants, changes to intellectual property laws to extend market exclusivity periods, and modification of premarket testing regulations to reduce antibiotic development time and expenses. (shrink)

En marzo de 2023, en la Facultad de Humanidades de UAEMéx, se llevó a cabo el primer congreso internacional dedicado específicamente a la Filosofía Mexicana, coincidiendo con los 80 años de la publicación de la Historia escrita por Ramos. En este evento, se mostró el avance enorme y la consolidación nacional e internacional de nuestra filosofía. En la presente obra se da cuenta de parte de los trabajos presentados en este evento académico, dejando al lector un acercamiento al mundo plural (...) y amplio que en la actualidad representa esta línea de investigación. (shrink)

This collection of essays is the first of its kind to focus on the relationship between composition and identity. Twelve original articles--written by internationally renowned scholars and rising stars in the field--argue for and against the controversial doctrine that composition is identity.--Provided by publisher.

The aim of this paper is to bring recent work on metaphysical grounding to bear on the phenomenon of social construction. It is argued that grounding can be used to analyze social construction and that the grounding framework is helpful for articulating various claims and commitments of social constructionists, especially about social identities, e.g., gender and race. The paper also responds to a number of objections that have been leveled against the application of grounding to social construction from Elizabeth Barnes, (...) Mari Mikkola, and Jessica Wilson. (shrink)

I examine the link between extensionality principles of classical mereology and the anti‐symmetry of parthood. Varzi's most recent defence of extensionality depends crucially on assuming anti‐symmetry. I examine the notions of proper parthood, weak supplementation and non‐well‐foundedness. By rejecting anti‐symmetry, the anti‐extensionalist has a unified, independently grounded response to Varzi's arguments. I give a formal construction of a non‐extensional mereology in which anti‐symmetry fails. If the notion of ‘mereological equivalence’ is made explicit, this non‐anti‐symmetric mereology recaptures all of the structure (...) of classical mereology. (shrink)

Does a commitment to mereological universalism automatically bring along a commitment to the controversial doctrine of mereological extensionalism—the view that objects with the same proper parts are identical? A recent argument suggests the answer is ‘yes’. This paper attempts a systematic response to the argument, considering nearly every available line of reply. It argues that only one approach—the mutual parts view—can yield a viable mereology where universalism does not entail extensionalism.

The dominant theory of parts and wholes – classical extensional mereology – has faced a number of challenges in the recent literature. This article gives a sampling of some of the alleged counterexamples to some of the more controversial principles involving the connections between parthood and identity. Along the way, some of the main revisionary approaches are reviewed. First, counterexamples to extensionality are reviewed. The ‘supplementation’ axioms that generate extensionality are examined more carefully, and a suggested revision is considered. Second, (...) the paper considers an alternative approach that focuses the blame on antisymmetry but allows us to keep natural supplementation axioms. Third, we look at counterexamples to the idempotency of composition and the associated ‘parts just once’ principle. We explore options for developing weaker mereologies that avoid such commitments. (shrink)

The goal of this paper is to make headway on a metaphysics of social construction. In recent work, I’ve argued that social construction should be understood in terms of metaphysical grounding. However, I agree with grounding skeptics like Wilson that bare claims about what grounds what are insufficient for capturing, with fine enough grain, metaphysical dependence structures. To that end, I develop a view on which the social construction of human social kinds is a kind of realization relation. Social kinds, (...) I argue, are multiply realizable kinds. I depart from the Wilson by further arguing that an appeal to grounding is not otiose when it comes to social construction. Social construction, I claim, belongs to the “big-G” Grounding genus, but it is the specific “small-g” relation of realization at work in cases of human kind social construction. (shrink)

Mereological nihilists are faced with a difficult challenge: explaining ordinary talk about material objects. Popular paraphrase strategies involve plurals, arrangements of particles, or fictions. In this paper, a new paraphrase strategy is put forward that has distinct advantages over its rivals: it is compatible with gunk and emergent properties of macro-objects. The only assumption is a commitment to a liberal view of the nature of simples; the nihilist must be willing to accept the possibility of heterogeneous extended simples. The author (...) suggests reinterpreting the parthood and composition relations as modal. According to this paraphrase, composition is a kind of counterpart relation. The author shows that one can accept that mereological nihilism is metaphysically necessary, while endorsing all the claims of classical mereology. As a result, the nihilists are in exactly the same position as the classical mereologist when it comes to explaining talk about ordinary objects, but without the additional ontology. (shrink)

Bayesian Conditionalization is a widely used proposal for how to update one’s beliefs upon the receipt of new evidence. This is in part because of its attention to the totality of one’s evidence, which often includes facts about what one’s new evidence is and how one has come to have it. However, an increasingly popular position in epistemology holds that one may gain new evidence, construed as knowledge, without being in a position to know that one has gained this evidence. (...) These are cases of KK-Failure, cases where one knows p but is not in a position to know that one knows p. This paper assumes that certain KK-Failures are possible and argues that Conditionalization goes wrong in those cases. (shrink)

Many of the most popular genres of narrative art are designed to elicit negative emotions: emotions that are experienced as painful or involving some degree of pain, which we generally avoid in our daily lives. Melodramas make us cry. Tragedies bring forth pity and fear. Conspiratorial thrillers arouse feelings of hopelessness and dread, and devotional religious art can make the believer weep in sorrow. Not only do audiences know what these artworks are supposed to do; they seek them out in (...) pursuit of prima facie painful reactions.Traditionally, the question of why people seek out such experiences of painful art has been presented as the paradox of tragedy. Most solutions to the paradox of tragedy assume that the reason we seek out tragedies, horror films, melodramas, and the like is because they afford pleasureful experiences. From there, theorists attempt to account for the source of this pleasure, a pleasure assumed to be had from representations of events from which we do not derive pleasure in real life. I argue that this assumption is suspect: the motive for seeking out devotional religious art, melodrama, tragedy, and some horror is not clearly to find pleasure. (shrink)

In this third edition of "John Locke", the text is divided into three parts. The first is biographical, giving an account of the development of Locke's mind. The second expounds the teaching of the "Essay", and relates this to its background; while the third deals with Locke's teaching in political theory, moral philosophy, education, and religion. -- From publisher's description.

Over the last few decades, skepticism about political and moral experts has grown into a serious social problem, undermining the functioning of liberal democratic regimes. Indeed, meritocracy-that is, government by hard working, public-spirited people with high levels of relevant expertise-has never looked so promising as an alternative to the dangers of know-nothing populism. One cultural tradition has devoted sustained attention to the idea of meritocracy, as well as to the cultivation of true expertise or mastery: Confucianism. Mastery, Dependence, and the (...) Ethics of Authority presents a compelling analysis of expertise and authority, and examines classical Confucian conceptions of mastery, dependence, and human relationships in order to suggest new approaches to these issues in ethics and political theory. Contemporary Westerners are heirs to multiple traditions that are suspicious of authority, especially coercive political authority. We are also increasingly wary of dependence, which now often seems to signify weakness, neediness, and pathology. Analysts commonly presume that both authority and dependence threaten human autonomy, and are thus intrinsically problematic. But these judgments are mistaken. Our capacity for autonomy needs to be cultivated over time through deliberate practices of training, in which we depend on the guidance of virtuous and skilled teachers. Confucian thought provides a subtle and powerful analysis of one version of this training process, and of the social supports such an education in autonomy requires-as well as the social value of having virtuous and skilled leaders. Early Confucians also argue that human life is marked by numerous interacting forms of dependence, which are not only ineradicable, but in many ways good. On a Confucian view, it is natural, healthy, and good for people to be deeply dependent on others in a variety of ways across the full human lifespan. They teach us that individual autonomy only develops within a social matrix, structured by relationships of mutual dependence that can either help or hinder it, including a variety of authority relations. (shrink)

Ontological pluralism holds that there are different ways of being. Truth pluralism holds that there are different ways of being true. Both views have received growing attention in recent literature, but so far there has been very little discussion of the connections between the views. The authors suggest that motivations typically given for truth pluralism have analogue motivations for ontological pluralism; they argue that while neither view entails the other, those who hold one view and wish to hold the other (...) will find natural routes by which to do so. The authors additionally identify some disanalogies between the views, by considering whether certain “mixed” problems commonly pressed against truth pluralism have analogues for ontological pluralism. (shrink)

Photographs furnish evidence. This is true in both formal and informal contexts. The use of photographs as legal evidence goes back to the very earliest days of photography, and they have been used in American trials since around the time of the Civil War. Photographs may also serve as historical evidence (for example, about the Civil War). And they serve in informal contexts as evidence about all sorts of things, such as what we and our loved ones looked like in (...) the past. (shrink)

The analogy between gustatory taste and critical or aesthetic taste plays a recurring role in the history of aesthetics. Our interest in this article is in a particular way in which gustatory judgments are frequently thought to be analogous to critical judgments. It appears obvious to many that to know how a particular object tastes we must have tasted it for ourselves; the proof of the pudding, we are all told, is in the eating. And it has seemed just as (...) obvious to many philosophers that aesthetic judgment requires first-person experience. In this article we argue that, despite its initial appeal, the claim that gustatory and critical judgments are analogous in this way is mistaken. The two sorts of judgments are, as a matter of fact, similar in their epistemology, but earlier theorists have got things entirely backward—neither gustatory judgment nor aesthetic judgment requires first-hand acquaintance with their objects. Our particular focus in this article is on arguing that first-person experience is not required to know how an item of food or drink tastes. In fact, there are a wide variety of ways in which we can acquire this knowledge. (shrink)

In classical extensional mereology, composition is idempotent: if x is part of y, then the sum of x and y is identical to y. In this paper, I provide a systematic and coherent formal mereology for which idempotence fails. I first discuss a number of purported counterexamples to idempotence that have been put forward in the literature. I then discuss two recent attempts at sketching non-idempotent formal mereology due to Karen Bennett and Kit Fine. I argue that these attempts are (...) incomplete, however, and there are many open issues left unresolved. I then construct a class of models of a non-idempotent mereology using multiset theory, consider their algebraic structure, and show how these models can shed light on the open issues left from the previous approaches. (shrink)

Constitutivist accounts of self-knowledge argue that a noncontingent, conceptual relation holds between our first-order mental states and our introspective awareness of them. I explicate a constitutivist account of our knowledge of our own beliefs and defend it against criticisms recently raised by Christopher Peacocke. According to Peacocke, constitutivism says that our second-order introspective beliefs are groundless. I show that Peacocke’s arguments apply to reliabilism not to constitutivism per se, and that by adopting a functionalist account of direct accessibility a constitutivist (...) can avoid reliabilism. I then argue that the resulting view is preferable to Peacocke’s own account of self-knowledge. (shrink)

We present a new axiomatization of classical mereology in which the three components of the theory—ordering, composition, and decomposition prin-ciples—are neatly separated. The equivalence of our axiom system with other, more familiar systems is established by purely deductive methods, along with additional results on the relative strengths of the composition and decomposition axioms of each theory.

Some democratic theorists have argued that contemporary people should practice only a civility that recognizes others as equal persons, and eschew any form of deference to authority as a feudalistic cultural holdover that ought to be abandoned in the modern era. Against such views, this essay engages early Confucian views of ethics and society, including their analyses of different sorts of authority and status, in order to argue that, properly understood, deference is indeed a virtue of considerable importance for contemporary (...) democratic societies and the citizens who constitute them. (shrink)

Investments in mitigating climate change have their greatest environmental impact over the long term. As a consequence the incentives to invest in cutting greenhouse gas emissions today appear to be weak. In response to this challenge, there has been increasing attention given to the idea that current generations can be motivated to start financing mitigation at much higher levels today by shifting these costs to the future through national debt. Shifting costs to the future in this way benefits future generations (...) by break- ing existing patterns of delaying large-scale investment in low-carbon energy and efficiency. As we will see in this chapter, it does appear to be technically feasible to transfer the costs of investments made today to the future in such a way that people alive today do not incur any net cost. the aim of this chapter is to take seriously the possibility that climate change has produced an extremely intractable political problem and that we must now consider strong measures that can break existing patterns of delaying mitigation. I defend the claim that if climate change involves a stark conflict of interests between current and future generations, then borrowing from the future would be both strategically and normatively much better than the status quo. Nevertheless, I challenge the borrowing from the future proposal on the grounds that it is not in fact the powerful tool for motivating existing agents that its proponents imagine it to be. The purpose of developing this critical argument is not, however, simply to throw doubt onto the idea of borrowing from the future. If we really do find ourselves in a political context where the prospects for effective action are very poor then strategic forms of buck-passing may make an important positive contribution to avoiding dangerous global cli- mate change. Consequently, if debt financing is not as powerful of a motivational tool as imagined we still have strong reasons, I will argue, to identify other strategies that will change agents’ incentive structures. To this end, I propose an alternative form of passing on the costs of mitigation to the future that warrants consideration. (shrink)

Perichoresis, or “mutual indwelling,” is a crucial concept in Trinitarian theology. But the philosophical underpinnings of the concept are puzzling. According to ordinary conceptions of “indwelling” or “being in,” it is incoherent to think that two entities could be in each other. In this paper, I propose a mereological way of understanding “being in,” by analogy with standard examples in contemporary metaphysics. I argue that this proposal does not conflict with the doctrine of divine simplicity, but instead affirms it. I (...) conclude by discussing how mutual indwelling relates to the concepts of unity and identity. (shrink)

Recent philosophical discussions of self-knowledge have focused on basic cases: our knowledge of our own thoughts, beliefs, sensations, experiences, preferences, and intentions. Empiricists argue that we acquire this sort of self-knowledge through inner perception; rationalists assign basic self-knowledge an even more secure source in reason and conceptual understanding. I try to split the difference. Although our knowledge of our own beliefs and thoughts is conceptually insured, our knowledge of our experiences is relevantly like our perceptual knowledge of the external world.

This paper is an attempt to summarise and justify critical comments I have been making over several decades about research on consciousness by philosophers, scientists and engineers. This includes (a) explaining why the concept of "phenomenal consciousness" (P-C), in the sense defined by Ned Block, is semantically flawed and unsuitable as a target for scientific research or machine modelling, whereas something like the concept of "access consciousness" (A-C) with which it is often contrasted refers to phenomena that can be described (...) and explained within a future scientific theory, and (b) explaining why the "hard problem" is a bogus problem, because of its dependence on the P-C concept. It is compared with another bogus problem, "the 'hard' problem of spatial identity" introduced as part of a tutorial on semantically flawed concepts. Different types of semantic flaw and conceptual confusion not normally studied outside analytical philosophy are distinguished. The semantic flaws of the "zombie" argument, closely allied with the P-C concept are also explained. These topics are related both to the evolution of human and animal minds and brains and to requirements for human-like robots. The diversity of the phenomena related to the concept "consciousness" as ordinarily used makes it a polymorphic concept, partly analogous to concepts like "efficient", "sensitive", and "impediment" all of which need extra information to be provided before they can be applied to anything, and then the criteria of applicability differ. As a result there cannot be one explanation of consciousness, one set of neural associates of consciousness, one explanation for the evolution of consciousness, nor one machine model of consciousness. We need many of each. I present a way of making progress based on what McCarthy called "the designer stance", using facts about running virtual machines, without which current computers obviously could not work. I suggest the same is true of biological minds, because biological evolution long ago "discovered" a need for something like virtual machinery for self-monitoring and self-extending information-processing systems, and produced far more sophisticated versions than human engineers have so far achieved. (shrink)

This paper extends three decades of work arguing that researchers who discuss consciousness should not restrict themselves only to (adult) human minds, but should study (and attempt to model) many kinds of minds, natural and artificial, thereby contributing to our understanding of the space containing all of them. We need to study what they do or can do, how they can do it, and how the natural ones can be emulated in synthetic minds. That requires: (a) understanding sets of requirements (...) that are met by different sorts of minds, i.e. the niches that they occupy, (b) understanding the space of possible designs, and (c) understanding complex and varied relationships between requirements and designs. Attempts to model or explain any particular phenomenon, such as vision, emotion, learning, language use, or consciousness lead to muddle and confusion unless they are placed in that broader context. A methodology for making progress is summarised and a novel requirement proposed for a theory of how human minds work: the theory should support a single generic design for a learning, developing system that, in addition to meeting familiar requirements, should be capable of developing different and opposed philosophical viewpoints about consciousness, and the so-called hard problem. In other words, we need a common explanation for the mental machinations of mysterians, materialists, functionalists, identity theorists, and those who regard all such theories as attempting to answer incoherent questions. No designs proposed so far come close. (shrink)

Our goal here is to help identify the contextualist’s most worthy competitor to relativism. Recently, some philosophers of language and linguists have argued that, while there are contextualist-friendly semantic theories of deontic modals that fit with the relativist’s challenge data, the best such theories are not Lewis-Kratzer-style semantic theories. If correct, this would be important: It would show that the theory that has for many years enjoyed the status of the default view of modals in English and other languages is (...) in need of revision. Here we defend the default view by showing how a Kratzer-style semantics is able to make available readings of the relevant utterances that fit with the pretheoretical judgments opponents purport it cannot fully capture. Having established this, we turn to considering the more theoretical grounds proponents have offered for preferring their rival contextualist views. Here the question is to what extent such grounds favor semantic over what Korta and Perry call “near-side pragmatic” explanations of our judgments. In particular, we argue that our favored readings figure in near-side pragmatic explanations of those judgments that possess the methodological and theoretical advantages of systematicity and unity at least as well as, if not to a greater extent than, those of opponents who argue for their revised semantic theories on the basis of these advantages. (shrink)

This paper is about how to give human-like powers to complete agents. For this the most important design choice concerns the overall architecture. Questions regarding detailed mechanisms, forms of representations, inference capabilities, knowledge etc. are best addressed in the context of a global architecture in which different design decisions need to be linked. Such a design would assemble various kinds of functionality into a complete coherent working system, in which there are many concurrent, partly independent, partly mutually supportive, partly potentially (...) incompatible processes, addressing a multitude of issues on different time scales, including asynchronous, concurrent, motive generators. Designing human like agents is part of the more general problem of understanding design space, niche space and their interrelations, for, in the abstract, there is no one optimal design, as biological diversity on earth shows. (shrink)

Berys Gaut has recently articulated and defended a putatively anti-definitional ‘cluster’ theory of art. In the first part of this paper, I argue that Gaut's version of the cluster account is flawed. The key notion of ‘counting toward the application of a concept’ is formulated in such a way that a range of apparently irrelevant properties will count as criterial for the concept of art. Moreover, there does not appear to be any quick fix to this problem. I then turn (...) to an exploration of the relationship between the cluster theory and the possibility of defining art. Gaut has claimed that the truth of the cluster account would provide an independent basis for rejecting the possibility of an adequate definition of art. I argue that this is not the case. But while the truth of the cluster account is consistent with definition, I also argue that it would not entail the definability of art in any ordinary sense. (shrink)

ABSTRACT Much has been made of the apparent tensions in Nietzsche's ethical and metaethical views. In this essay I examine a kind of value standard available to Nietzsche that is present in his work. I offer an interpretation of honesty as both a Nietzschean virtue and a means of ethical assessment. Despite Nietzsche's well-known criticisms of truth, he upholds honesty as the only remaining virtue of his free spirits. Honesty has been treated in the literature primarily in the contexts of (...) truth or life affirmation, but I argue that we should instead recognize honesty as a virtue within the context of valuing. I defend honesty as a distinct kind of truthfulness and sincerity involving what I call confrontation. The seeds of Nietzsche's mature view are first evident in his work on tragedy, then developed further in Zarathustra, ultimately revealing a constraint on valuing that is essential to Nietzsche's broader normative projects. (shrink)

Journal of Social Philosophy, EarlyView.

Spurred by a severe shortage of cadaveric organs, there has been a marked growth in living organ donation over the past several years. This has stimulated renewed interest in the ethics of this practice. The major concern has always been the possibility that a physician may seriously harm one person while trying to improve the well-being of another. As Carl Elliott points out, this puts the donor's physician in a difficult predicament: when evaluating a person who volunteers to donate an (...) organ, “a doctor is in the position of deciding not simply whether a subject's choice is reasonable … but whether he [the doctor] is morally justified in helping the subject accomplish it.”1 This question has become even more difficult since the introduction of living donor operations that are more risky than living kidney donation and the suggestion that volunteers at added risk may sometimes be acceptable.2 So, how can we decide when the risk is too much? (shrink)

Comparative religious ethics is a complicated scholarly endeavor, striving to harmonize intellectual goals that are frequently conceived as quite different, or even intrinsically opposed. Against commonly voiced suspicions of comparative work, this essay argues that descriptive, comparative, and normative interests may support rather than conflict with each other, depending on the comparison in question, and how it is pursued. On the basis of a brief comparison of the early Christian Augustine of Hippo and the early Confucians Mencius and Xunzi on (...) the topic of "human nature," this paper advocates a particular account of comparative religious ethics, and argues for the complexity of the idea of "human nature." Different elements of this family of concerns are central to religious ethics generally, and to theories and practices of moral development and personal formation specifically. (shrink)

What is the relation between intelligence and computation? Although the difficulty of defining `intelligence' is widely recognized, many are unaware that it is hard to give a satisfactory definition of `computational' if computation is supposed to provide a non-circular explanation for intelligent abilities. The only well-defined notion of `computation' is what can be generated by a Turing machine or a formally equivalent mechanism. This is not adequate for the key role in explaining the nature of mental processes, because it is (...) too general, as many computations involve nothing mental, nor even processes: they are simply abstract structures. We need to combine the notion of `computation' with that of `machine'. This may still be too restrictive, if some non-computational mechanisms prove to be useful for intelligence. We need a theory-based taxonomy of {\em architectures} and {\em mechanisms} and corresponding process types. Computational machines my turn out to be a sub-class of the machines available for implementing intelligent agents. The more general analysis starts with the notion of a system with independently variable, causally interacting sub-states that have different causal roles, including both `belief-like' and `desire-like' sub-states, and many others. There are many significantly different such architectures. For certain architectures (including simple computers), some sub-states have a semantic interpretation for the system. The relevant concept of semantics is defined partly in terms of a kind of Tarski-like structural correspondence (not to be confused with isomorphism). This always leaves some semantic indeterminacy, which can be reduced by causal loops involving the environment. But the causal links are complex, can share causal pathways, and always leave mental states to some extent semantically indeterminate. (shrink)

The most interesting and perilous issue at present in comparative religious ethics is comparative ethical judgment—when and how to judge others, if at all. There are understandable historical and conceptual reasons for the current tendency to prefer descriptive over normative work in comparative religious ethics. However, judging those we study is inescapable—it can be suppressed or marginalized but not eliminated. Therefore, the real question is how to judge others (and ourselves) well, not whether to judge. Instead of bringing supposedly universal (...) moral scoring systems to bear on reified "traditions" and "cultures," it would be better to focus on the precise details of particular practices, motifs, and theories in various settings, and compare them with an eye to substantive issues of current ethical concern. (shrink)

The affective sciences are essential to research regarding sustainable transition towards renewable energy. We focus on important questions that should be addressed by affective science in relation to the siting of large-scale renewable energy projects like wind and solar. Considering the recent acceleration of the transition, a more holistic understanding of negative and positive emotional responses to energy development will be essential. This is particularly important as the least controversial sites begin to dwindle in number. We break this commentary down (...) into four primary question categories for future research. These are the causal relationships between emotional elicitations and their sources, dual processing through cognitive and affective response, affect and its relationship with place, and how all of these elements change over time. (shrink)