This thoughtful new abridgment is enriched by the brilliant commentary which accompanies it. In it, Laurence Dickey argues that the _Wealth of Nations_ contains--and conceals--a great deal of how Smith actually thought a commercial society works. Guided by his conviction that the so-called Adam Smith Problem--the relationship between ethics and economics in Smith's thinking--is a core element in the argument of the work itself, Dickey's commentary focuses on the devices Smith uses to ground his economics in broadly ethical and (...) social categories. An unparalleled guide to an often difficult and perplexing work. (shrink)

Industrial drug design methodology has undergone remarkable changes in the recent history. Up to the 1970s, the screening of large numbers of randomly selected substances in biological test system was often a crucial step in the development of novel drugs. From the early 1980s, such ‘blind’ screening was increasingly rejected by many pharmaceutical researchers and gave way to ‘rational drug design’, a method that grounds the design of new drugs on a detailed mechanistic understanding of the drug action. Surprisingly, however, (...) the chance-based method of random screening returned to center stage of industrial drug development in the 1990s in the form of ‘high-throughput screening’ (HTS). I will argue in this paper that this to-and-fro in the prominence of random screening comes with fundamental changes in the epistemic significance of chance experiments in pharmaceutical development. While up to the 1970s, random screening used to be chosen as an empirical search strategy primarily because suffi- cient knowledge of the mechanistic basis of drug action was lacking, it has turned with high-throughput screening into an experimental method that employs chance variation and testing to illuminate this mechanistic basis. As a consequence, research into the underlying mechanisms of drug action and the development of new drugs have become closely integrated. The rise of HTS therefore not only shows how chance experiments have assumed a new epistemic role in drug development. It also allows for a detailed study of the much debated emergence of a new relationship between scientific understanding and the development of technological artifacts. (shrink)

Noise in behavior is often viewed as a nuisance: while the mind aims to take the best possible action, it is let down by unreliability in the sensory and response systems. How researchers study cognition reflects this viewpoint – averaging over trials and participants to discover the deterministic relationships between experimental manipulations and their behavioral consequences, with noise represented as additive, often Gaussian, and independent. Yet a careful look at behavioral noise reveals rich structure that defies easy explanation. First, both (...) perceptual and preferential judgments show that sensory and response noise may potentially only play minor roles, with most noise arising in the cognitive computations. Second, the functional form of the noise is both non-Gaussian and non-independent, with the distribution of noise being better characterized as heavy-tailed and as having substantial long-range autocorrelations. It is possible that this structure results from brains that are, for some reason, bedeviled by a fundamental design flaw, albeit one with intriguingly distinctive characteristics. Alternatively, noise might not be a bug but a feature: indeed, we suggest that noise is fundamental to how cognition works. Specifically, we propose that the brain approximates probabilistic inference with a local sampling algorithm, one that uses randomness to drive its exploration of alternative hypotheses. Reframing cognition in this way explains the rich structure of noise and leads to a surprising conclusion: that noise is not a symptom of cognitive malfunction but plays a central role in underpinning human intelligence. (shrink)

This article develops a media philosophical framework for addressing the intersection of epigenetics and complex dynamical systems in theoretical biology. In particular, it argues that the theoretical humanities need to think critically about the computability of epigenomic regulation, as well as speculatively about the possibility of an epigenomics beyond complexity. The fact that such a conceptual framework does not exist suggests not only a failure to engage with the mathematics of complexity, but also a failure to engage with its history. (...) Both epigenetics and the application of complex dynamical systems to biology originate in the mid-twentieth-century work of Conrad Hal Waddington. The article demonstrates how this genealogy of epigenetic complexity reveals the need for a speculative conception of epigenomic mediation beyond mathematical complexity. Using Whitehead’s philosophy as a conceptual anchor, the “epimedial landscape” serves as a first pass at a media philosophical revision of the complex dynamical systems view of the epigenetic landscape. (shrink)

In the Typic chapter of the Critique of Practical Reason, Kant aims to enable moral judgment by means of the law of nature, which serves as the ‘type’, or formal analogue, of moral law. The present monograph is the first comprehensive study of this key text. It provides a detailed commentary on the Typic, situates it within Kant’s ethics and his theory of symbolic representation, and critically engages with the relevant secondary literature.

It is common to encounter the criticism that Joseph Raz’s service conception of authority is flawed because it appears to justify too much. This essay examines the extent to which the service conception accommodates this critique. Two variants of this critical strategy are considered. The first, exemplified by Kenneth Einar Himma, alleges that the service conception fails to conceptualize substantive limits on the legitimate exercise of authority. This variant fails; Raz has elucidated substantive limits on jurisdiction within the service conception (...) of authority, albeit reluctantly and equivocally. The second, exemplified by Scott Hershovitz, alleges that the service conception fails to conceptualize procedural limits on the legitimate exercise of authority. He objects that the normal justification thesis fails to deny legitimacy to rational and expert dictators. This argument is more potent, but its force is concealed when it is aimed at the normal justification thesis rather than the quite separate jurisdictional limits of Raz’s theory. Clarifying those jurisdictional aspects of the service conception shows why the first argument fails and exposes the real strength of the second. Both variants have important consequences for our understanding of the service conception. (shrink)

The clinical concept of projective identification encompasses both unconscious fantasies of putting aspects of oneself into another person, as well as interpersonal processes aimed at evoking a corresponding response in another person, all for purposes of defensive evacuation, control and/or communication.1 In thinking about this complex situation, we need to consider its interpersonal dimensions as well as the intrapsychic processes that take place in each party. Louise Braddock's paper is thought provoking, far-reaching, and important in its use of concepts from (...) analytic philosophy to attempt to bring clarity on both fronts. Her account makes use of two crucial philosophical notions... (shrink)

A fascinating exploration of the nature of consciousness This engaging and readable book provides an introduction to consciousness that does justice both to the science and to the philosophy of consciousness, that is, the mechanics of the mind and the experience of awareness. The book opens with a general discussion of the brain and of consciousness itself. Then, exploring the areas of brain science most likely to illuminate the basis of awareness, Zeman focuses on the science of sleep and waking (...) and on the science of vision. He describes healthy states and disorders--epilepsy, narcolepsy, blindsight and hallucinations after stroke--that provide insights into the capacity for consciousness and into its contents. And he tracks the evolution of the brain, the human species, and human culture and surveys the main current scientific theories of awareness, pioneering attempts to explain how the brain gives rise to experience. Zeman concludes by examining philosophical arguments about the nature of consciousness. A practicing neurologist, he animates his text with examples from the behavioral and neurological disorders of his patients and from the expanding mental worlds of young children, including his own. His book is an accessible and enlightening explanation of why we are conscious. (shrink)

The notion of the supernaturality of an event may be understood in various ways. Most frequently ‘supernatural’ means ‘separated from nature’, i.e. different from nature. Thus, what is meant here is the difference in ontological character. The definitions of miracle, present in literature, emphasize the fact that we may talk about a miracle only when the phenomenon takes place beyond the natural order or stands in opposition to it. The description of a miracle as a ‘supernatural event’ contains in itself (...) the reference to that which is natural. The supernaturality of an event means that it surpasses (transcends) naturality. Additionally, this transcendence contains a kind of opposition to that which is natural. However, the miracle as a supernatural event takes place within the scope of that which is natural, although it takes place in a different way from natural events. It seems that this supernaturality may involve two things: (1) the course of the miraculous event; (2) the cause of the miraculous event. We should consider each of them separately and specify what we understand by the supernatural course of the event and by the supernatural cause of the event. If we could prove that we can talk about supernatural events at least in one of the two signaled aspects of supernaturality, then we would be able to define the miraculous event as a supernatural one. The analyses proposed in the paper allow us to formulate the following statement concerning the miraculous event, which is, to a great extent, a critical correction of the traditional way of understanding it: the miracle may be correctly understood as a supernatural event, only when this supernaturality concerns the personal cause of the event and not its course. (shrink)

Autor omawianej publikacji podjął się zadania przeanalizowania zaproponowanych dotąd interpretacji „zaćmienia darwinizmu”, chcąc ustalić, w jakim stopniu odpowiadają one rzeczywistości. Po dokonaniu ustaleń w tym zakresie doszedł do wniosku, że żadna z nich nie wyjaśnia w sposób adekwatny załamania się, jakie dotknęło teorię Darwina we wspomnianym okresie. Dlatego postanowił zaproponować własną interpretację „zaćmienia darwinizmu”, w której odwołuje się przede wszystkim do filozoficznych uwarunkowań darwinowskiej teorii ewolucji. --------------- Zgłoszono: 04/08/2021. Zrecenzowano: 19/08/2021. Zaakceptowano do publikacji: 06/09/2021.

Legal theorists standardly hold that stability is one of eight necessary conditions for legal guidance. We lack an adequate explanation, however, of why, exactly, stability is necessary in order that law possess the capacity to guide behavior. Standard explanations, which rely on a claim about reasonable expectations, fail to connect the concepts of stability and legal guidance. In this paper, I argue that, according to the leading conception of legal guidance, stability is, in fact, not necessary in order for law (...) to possess the capacity to guide. In response, I provide an alternative conception of legal guidance, and argue that stability is a necessary attribute if we assume this conception of guidance. More generally, the paper sets out an abstract framework in which claims that this or that property is necessary for legal guidance can be assessed. (shrink)

One of the most problematic aspects of the ‘Harvard School’ of liberal international theory is its failure to fulfil its own methodological ideals. Although Harvard School liberals subscribe to a nomothetic model of explanation, in practice they employ their theories as heuristic resources. Given this practice, we should expect them neither to develop candidate causal generalizations nor to be value-neutral: their explanatory insights are underpinned by value-laden choices about which questions to address and what concepts to employ. A key question (...) for liberal theorists, therefore, is how a theory may be simultaneously explanatory and value-oriented. The difficulties inherent in resolving this problem are manifested in Ikenberry's writing: whilst his work on constitutionalism in international politics partially fulfils the requirements of a more satisfactory liberal explanatory theory, his recent attempts to develop prescriptions for US foreign policy reproduce, in a new form, key failings of Harvard School realism. (shrink)

This Is A New Release Of The Original 1898 Edition.

Within the discourse surrounding mind-body interaction, mental causation is intimately associated with non-reductive physicalism. However, such a theory holds two opposing views: that all causal properties and relations can be explicated by physics and that special sciences have an explanatory role. Jaegwon Kim attempts to deconstruct this problematic contradiction by arguing that it is untenable for non-reductive physicalists to explain human behavior by appeal to mental properties. In combination, Kim’s critique of mental causation and the phenomenal concept strategy serves as (...) an effectual response to the anti-physicalist stance enclosed within the Knowledge Argument and the Zombie Thought Experiment. (shrink)

Reason has very often been seen as the highest faculty of man and, therefore, a strong tendency to attempt to analyze man mainly in terms of the rational dimension exists. This tendency was strong in antiquity and was given renewed attention in the seventeenth century.

According to a common view, the activity of justifying is epistemologically irrelevant: being justified in believing as one does never requires the ability to justify one’s belief. This view runs into trouble regarding the epistemic basing relation, the relation between a person’s belief and the reasons for which the person holds it. The view must appeal to basing relations as part of its account of what it is for a person to be justified in believing as she does, but the (...) view prevents basing relations from doing the needed work. In place of the common view, I propose an account of basing relations which links them to the person’s commitments and hence to her justificatory activity. If this proposal is correct, then positive justificatory status, too, will be conceptually linked to the ability to succeed in the activity of justifying. (shrink)

Bacterial chemotaxis is often considered to be a textbook example of the rudimentary semiotic process. As such, it gives an excellent opportunity to better understand both semiosis and biology. Our study reviews this phenomenon in the light of up-to-date scientific knowledge to answer the most basic semiotic questions: what is the sign? What types of signs are there? What is the meaning understood on the molecular level, and by what means can it grow with time? As a case study, the (...) bacterial chemotaxis toward glucose in E. coli species is chosen, and the semiotic framework of Charles Sanders Peirce applied. The analyses provide us with the following results: the sign, in its ultimate nature, is a general process. Bacterial chemotaxis can be understood in terms of Peircean type, symbol, and argument. The meaning on the molecular level is entirely pragmatic and, in this case, reduced to a bacterial response to glucose. A sign can grow through sign generalization, the emergence of different sign categories, the integration of these categories in functional cycles, and the introduction of contextuality. The sign of bacterial chemotaxis extends from the cell signaling pathways up to the population level. The presented results advance our knowledge of sign processing in the context of semiotic evolution. (shrink)

In the twentieth century, economic modernization projects were often part of a broader programme of social engineering, which did not avoid – and in many cases assumed – the use of violence. The author analyses the relationship between definitions of modernity developed by the classic authors of modernization theory during the 1950s and 1960s, tries to look for their roots in Marx’s writings on colonialism, and shows the consequences of the radical version of such projects, using the example of the (...) Chinese modernization programme implemented by Mao. In conclusion, Leszczyński assumes that a clear relationship can be traced between socio-economic modernization programmes and political violence in the twentieth century. (shrink)

本书内容包括:论行为的合宜、论功劳和罪过;或者论报答和惩罚的对象、论评判我们自己的情感和行为的基础,兼论义务感等。.

ABSTRACTThe articles Maximality and Refutability Skura [. Maximality and refutability. Notre Dame Journal of Formal Logic, 45, 65–72] and Three-valued Maximal Paraconsistent Logics Skura and Tuziak [. Three-valued maximal paraconsistent logics. In Logika. Wydawnictwo Uniwersytetu Wrocławskiego] introduced a simple method of proving maximality of a given paraconsistent matrix. This method stemmed from the so-called refutation calculus, where the focus in on rejecting rather than accepting formulas. The article A Generalisation of a Refutation-related Method in Paraconsistent Logics Trybus [. A generalisation (...) of a refutation-related method in paraconsistent logics. Logic and Logical Philosophy, 27. doi:10.12775/llp.2018.002] was a first step towards generalising the method. In it, a number of 3-valued paraconsistent matrices were shown maximal. In this article we extend these results to cover a number of n-valued paraconsistent matrices using the same method. (shrink)

On 21 August 1912 Christine Ladd-Franklin, by then an established logician, wrote a letter to Bertrand Russell. He replied on 27 September 1912, followed by another letter on 16 November of that year. After a hiatus on his side in 1913–14, they exchanged letters again in 1915. The main topic of their conversations is solipsism: a theme that was important for Russell throughout his writings. In fact, in some of his works he famously mentions his encounters with Ladd-Franklin, hinting at (...) a difference of opinions and her inability to see the inconsistency in what she claimed. After analysing the correspondence, with some letters resurfacing only recently, one sees a completely different picture: Russell not only does not object to what she claims, he even agrees with her! This article aims to show what really transpired as evidenced by the letters, of which seven of the extant eleven are reproduced in full with annotations. (shrink)