During the last few months, several pioneer genome‐wide transcriptomic, proteomic and metabolomic studies have revolutionised the understanding of bacterial biological processes, leading to a picture that resembles eukaryotic complexity. Technological advances such as next‐generation high‐throughput sequencing and high‐density oligonucleotide microarrays have allowed the determination, in several bacteria, of the entire boundaries of all expressed transcripts. Consequently, novel RNA‐mediated regulatory mechanisms have been discovered including multifunctional RNAs. Moreover, resolution of bacterial proteome organisation (interactome) and global protein localisation (localizome) have unveiled an (...) unanticipated complexity that highlights the significance of protein multifunctionality and localisation in the cell. Also, analysis of a complete bacterial metabolic network has again revealed a high fraction of multifunctional enzymes and an unexpectedly high level of metabolic responses and adaptation. Altogether, these novel approaches have permitted the deciphering of the entire physiological landscape of one of the smallest bacteria, Mycoplasma pneumoniae. Here, we summarise and discuss recent findings aimed at defining the blueprint of any prokaryote. (shrink)

It has been reported in non-contingent schedules that the variety of patterns of behavior is affected by the temporal variation of water deliveries. While temporal variation is accomplished by delivering water at fixed or variable times, spatial variation is usually accomplished by varying the number of dispensers and distance among them. Such criteria do not consider the possible ecological relevance of the location of water dispensers. Nevertheless, it is plausible to suppose that the intersection of the programed contingencies, the ecological (...) differentiated space, and the relative location of relevant objects and events could set up an integrated system with the behavioral patterns of the organism. In the present study, we evaluated the eco-functional relevance of two locations of the dispensers upon behavioral dynamics in Wistar rats using fixed and variable time schedules in a modified open-field system. In Experiment 1, three subjects were exposed to a fixed time 30-s water delivery schedule. In the first condition, the water dispenser was located at the center of the experimental chamber. In the second condition, the water dispenser was located at the center of a wall of the experimental chamber. Each location was present for 20 sessions. In Experiment 2, conditions were the same, but a variable time schedule was used. Routes, distance to the dispenser, recurrence patterns, time spent in zones, entropy, and divergence were analyzed. Our findings suggest a robust differential relevance of the location of the dispensers that should be considered in studies evaluating behavioral dynamics. Results are discussed from an integrative, ecological-parametric framework. (shrink)

ABSTRACT The objective of this study was to determine the accuracy of a brief informed consent quiz to detect consent comprehension in individuals with cognitive impairment and to explore the degree to which cognitive domains and recent substance use, independently, predict comprehension. We performed a secondary analysis of two cross-sectional studies in individuals with substance use disorders. The ICQ total score was used as the index test and the Montreal Cognitive Assessment as reference standard in receiver operating characteristic curves. Two (...) independent multiple binary logistic regression models were performed using cognitive domains and days of recent substance use as predictors of ICQ outcome. We analyzed data from 215 and 251 participants, respectively. The ICQ showed moderate accuracy for major cognitive impairment and lower accuracy for mild impairment. Optimal cutoff score was set at 10 points or less for detecting comprehension difficulty. Lower scores in Short-Term Memory, Attention, Language, and Orientation increased the probability of failing the ICQ. A procedure including both the ICQ and cognitive screening measure could improve the accuracy of consent comprehension assessments. (shrink)

In this essay I revise, based on the notion of the ‘enlightened ruler’ or mingzhu and his critique of the literati of his time, the common belief that Han Fei was an amoralist and an advocate of tyranny. Instead, I will argue that his writings are dedicated to advising those who ought to rule in order to achieve the goal of a peaceful and stable society framed by laws in accordance with the dao.

It is commonly accepted that Han Fei studied under Xunzi sometime during the late third century BCE. However, there is surprisingly little dedicated to the in-depth study of the relationship between Xunzi’s ideas and one of his best-known followers. In this essay I argue that Han Fei’s notion of xing, commonly translated as human nature, was not only influenced by Xunzi but also that it is an important feature of his political philosophy.

Purpose: This systematic review aimed to analyze the impact that the COVID-19 lockdown had on the amount of physical activity performed by university students.Materials and Methods: A systematic electronic search for studies providing information regarding physical activity levels pre and during COVID-19 pandemic in university students was performed up to 20th October 2020 in the databases Cochrane Library, PubMed, SPORTDiscus, and Web of Science. The risk of bias of external validity quality of included studies was assessed by means of those (...) the Newcastle-Ottawa Scale. The quality of the evidence for main outcomes was graded using the Grading of Recommendations Assessment, Development and Evaluation approach.Results and Conclusions: A total of 10 studies were selected. Physical activity levels were assessed by means of questionnaires and accelerometer. Risk of bias was regarded as low and high in six and four investigations, respectively. The quality of evidence was downgraded to low. A significant reduction of physical activity levels were observed in 9 studies. Compared to pre-lockdown values, five studies showed a reduction of light/mild physical activity between 32.5 and 365.5%, while seven studies revealed a reduction of high/vigorous physical activity between 2.9 and 52.8%. Walking, moderate, vigorous, and total physical activity levels have been reduced during the COVID-19 pandemic confinements in university students of different countries. Despite of the reductions, those who met the current minimum PA recommendations before the lockdown generally met the recommendations also during the confinements. (shrink)

Karl Popper held an opposition to determinism, based mainly in his political and ethical convictions. Nevertheless, most of his reflections upon it belong to epistemology. This paper studies Popper's refutation of determinism and his three main arguments of a priori nature against it. Some attention is paid also to the Popperian interpretation of quantic mechanical indeterminism.

We introduce a new compactness principle which we call the gluing property. For a measurable cardinal [Formula: see text] and a cardinal [Formula: see text], we say that [Formula: see text] has the [Formula: see text]-gluing property if every sequence of [Formula: see text]-many [Formula: see text]-complete ultrafilters on [Formula: see text] can be glued into an extender. We show that every [Formula: see text]-compact cardinal has the [Formula: see text]-gluing property, yet non-necessarily the [Formula: see text]-gluing property. Finally, we (...) compute the exact consistency strength for [Formula: see text] to have the [Formula: see text]-gluing property — this being [Formula: see text]. (shrink)

E. Berti habla en esta entrevista sobre sus estudios de filosofía, su descubrimiento del método dialéctico en Aristóteles, basado en las opiniones comunes, la importancia de la filosofía práctica de Aristótles y su concepto de la relación entre ética y política. La noción de técnica, que parece haber cobrado importancia en el último siglo, parece incapaz de afrontar los problemas metafísicos más elementales; esta es la razón por la que aún hoy necesitamos la metafísica.

The literary genesis of Einbahnstraße by Walter Benjamin represents a very special case of the use of the procedures of surrealism in the philosophical-literary production of the author. The process of evolution of thinking that ended up in the writing of this piece is unveiled throughout the present analysis. This is a sign of both waiver and restart; the opening for a new productive dimension in the career of one of the most important —and misunderstood— philosophers of the 20th century. (...) More than enlightening a small master piece of philosophy from a literary perspective, or analyzing a small master piece of literature from the philosophy, what is being problematized here is the division, cultivated or figured throughout the years, between both disciplines. This work is intended to recover what is insoluble from the philosophical-literary labor of Walter Benjamin, besides tracing a possible reconfiguration for an interdisciplinary field of work to come up and contribute in the understanding of the problem called The Retreat of Metaphor by Jacques Derrida. (shrink)

In 1 Corinthians 15:35–58, Paul combats disagreement in the Corinthian church over the nature of the resurrection. Paul’s argument for the physicality of the resurrection, and his location of the individual’s resurrection within a larger transformation and restoration of all creation, changes how the contemporary church understands and teaches Christian hope, sanctification, and mission.

Mi meta en este ensayo es, primero, reconstruir los puntos de vista de Marcelo Dascal en relación con las controversias filosóficas y, en segundo lugar, someterla a un examen crítico. Dejo en claro que las tesis de Dascal tienen un amplio rango de aplicaciones. Mi crítica se centra alrededor del concepto de conocimiento y de la idea misma de reconstrucción pragmática. Considero también la sugerente conexión que Dascal establece entre las controversias y el progreso intelectual.

A partir de las nociones de ficción, de animalidad y de mundo, el presente artículo pretende establecer ciertas ideas directrices para pensar los vínculos que las producciones culturales mantienen con la categoría de lo animal. El análisis de esta categoría se vincula igualmente a la problemática del sacrificio. Taking the concepts of fiction, animality, and world this article intends to lay down some leading ideas for analyzing the link between cultural productions and the animal category. This is also related to (...) the concept of sacrifice. (shrink)

Este trabajo se encuadra dentro de una nueva visión de la lógica de Leibniz, la cual pretende mostrar que sus escritos fueron ricos no solamente en proyectos ambiciosos sino también en desarrollos lógico-matematicos concretos. Se demuestra que su “Caracteristica Numerica” que asigna pares de números a las proposiciones categóricas es una semántiea para la cual la silogística aristotélica es correcta y completa, y que el sistema algebraico presentado en Fundamentos de un Cálculo Lógico es una lógica algebraica similar a la (...) de Boole.This work is a contribution to a new view of Leibniz’s logic, pretending to show that his writings were not only rich in projects, but also in concrete logico-mathematical developments. We prove that his “Numerical Characteristic” assigning pairs of numbers to terms of categorical propositions, is a complete and correct semantics for aristotelian syllogistic, and the algebraic system presented in Fundamentals of Logical Calculus is essentially a complete version of boolean algebraic logic. (shrink)

En los orígenes de la psicología humanista, diversos autores claves -entre ellos, Rogers- destacaron la importancia que la congruencia o autenticidad tiene para la salud integral de las personas. Tomando esta referencia como punto de partida, el autor examina lo que considera un momento crítico en la historia, teñido de escepticismo y cinismo, y sus manifestaciones en la vida actual. Finalmente, propone un modelo de autodesarrollo que considera tres niveles en cada ser humano: el nivel animal, el propiamente humano y (...) el divino. (shrink)

Taking into account Hegel´s suggestion on Novalis´ thought, we will outline the main characteristics of the concept of subjectivity for this author. Firstly, we will show the context in which this theory emerges. Secondly, we will elaborate on its relation with the question of Statement. Lastly, we will point out some aspects of Novalis´ Philosophy related to his conception of Subject, such as the questions of Art, Religion and men´s destiny in History.

Analizamos el discurso rectoral de Heidegger con el objetivo de comprender el sentido del término "nación alemana" en él. Sostenemos que el tratamiento que allí hace Heidegger de esta cuestión está profundamente relacionado con su lectura de la obra de Ernst Jünger, El Trabajador. Heidegger acepta en líneas generales el diagnóstico de Jünger sobre el mundo moderno, pero se diferencia de él precisamente en el sentido que atribuye a la nación alemana en esa situación. Analizamos el significado de la "misión (...) espiritual" que Heidegger atribuye a la nación alemana como fuerza capaz de contener el despliegue nihilista de la voluntad de poder a través de la técnica. Queremos demostrar que esa atribución intenta otorgar un nuevo significado a la nación en el horizonte histórico transformado por la "muerte de Dios" anunciada por Nietzsche y que explica el sentido de la posición política de Heidegger en 1933 y en los años inmediatamente posteriores. (shrink)

Este artículo aborda el proceso de proclamación como califa de Córdoba de Hišām, hijo y sucesor de al-Ḥakam II, cuando era todavía un niño de apenas once años. En relación con este aspecto, se analizan dos problemas. Desde el punto de vista jurídico, la cuestión de la legalidad del gobierno de un menor de edad en las sociedades islámicas clásicas. Por otro lado, la crisis política que la proclamación de Hišām desencadenó, debido a las resistencias que generaba en ciertos medios (...) palatinos y jurídicos su minoría. En este contexto, Ibn Abī ‘Āmir, futuro Almanzor, logró usurpar el ejercicio del poder, marginando por completo al califa y provocando con ello el descrédito de la institución califal. Por todo ello, la proclamación de Hišām constituye la primera fase en la crisis del califato de Córdoba, que acabó desembocando en su abolición. (shrink)

En este trabajo reconstruyo la concepción tractariana de los números naturales. Muestro cómo Wittgenstein usa su aparato conceptual (operación, conceptoformal, propiedad interna, forma lógica) para elaborar una definición de "número" alternativa a la logicista. Por último, examino brevemente algunas de lascríticas que se han elevado en su contra.

El artículo tiene como finalidad hacer una relectura y una revisión del pensamiento pedagógicode Paulo Freire desde la perspectiva intercultural. El pedagogo brasilero tuvo una extensacarrera como educador, enfrentó distintos contextos y coyunturas políticas y, si bien su arcode reflexión es amplio, no trata explícitamente la cuestión de la educación intercultural.Analizar esta ausencia sin contextualizarla puede hacernos caer en un anacronismo: la reflexiónen torno a la problemática señalada es relativamente reciente. Por tanto, se hacenecesaria una revisión que, paradójicamente, concluirá, más (...) que en una crítica, en una radicalizaciónintercultural de su pensamiento. (shrink)

_ This scholarly article explores the phenomenon of ocean acidification and its detrimental effects on marine ecosystems and biodiversity. It delves into the underlying causes, current trends, and potential future consequences of increasing acidity in the world's oceans. The article also discusses the impact on various marine organisms and ecosystems, emphasizing the urgent need for global awareness and concerted efforts to address this pressing environmental issue._.

Atran conjectures that a triggering algorithm for a living- kind module could involve inputs from other modules that detect animacy and intentionality. Here we further speculate about how algorithms for detecting specific intentions could be used to trigger between- or within-species categorization. Such categorization may be adaptively important in Eldredge's energy and information realms.

The possible linkages among liberty and power is a philosophical issue that gets to special important inside to contemporary political philosophy’s context. During this stage, a notion of legitimacy began to develop on which both freedom and power would be sustained, without being justified in a supposed statalist originin. Neither the legitimate power no the legitime freedom come to be backing by the juristic order up in the first instance, inasmuch up its source would be prior. From Foucault and Marcuse (...) outlooks on this issue, it will treat to inquire on the disquisitions that both their ever speeches propose. (shrink)

Resumen: Este artículo constituye una detallada exploración de la profunda transformación experimentada por el concepto de “historia” a la luz del salto intentado por Martin Heidegger desde la metafísica hacia el ámbito del pensamiento (del Ser). En un primer momento, la exposición sigue de cerca la lógica interna del pensar metafísico para demostrar luego con ello el carácter necesariamente metafísico de sus dos maneras de “procesar” la historia: la filosofía de la historia y la historiografía. Desde ahí, el artículo avanza (...) hacia un modo radicalmente nuevo de entender la naturaleza de la historia: aquello que Heidegger llama “el otro inicio”.Palabras clave: historia del ser; historiografía; filosofía de la historia; metafísica; ‘el otro inicio’. (shrink)

El trabajo que sigue presenta la obra Hiperión o el eremita en Grecia como un intento literario de pensar vías de unificación de la escisión fundamental de la conciencia planteada en el texto Juicio y ser. Partiendo de una diferenciación de los diversos planos narrativos de la novela, mostramos la insuficiencia de las experiencias de unidad vividas por Hiperión como consecuencia de una falta de comprensión del carácter > de la Naturaleza. Asimismo, justificamos la necesidad de un final inconcluso de (...) la novela y la función que desempeña la gratitud como disposición anímica desde la que cantar poéticamente la realidad. (shrink)

La fe en el progreso técnico ha llevado a la liberación de las energías de la naturaleza y con ello, como dice Heidegger, se ha inaugurado el peligro de “ser absorbido por la tecnología”. En esta línea se encuentra las propuestas del transhumanismo, como el biomejoramiento humano, tratando de superar las limitaciones humanas como la salud, el conocimiento, la afectividad y moral, y mortalidad haciendo uso de las nuevas tecnologías NBIC. El filósofo francés, Fabrice Hadjadj, es un nuevo referente en (...) la discusión del transhumanismo con sus análisis sobre la tecnología y la corporeidad humana. Mi propósito es mostrar las críticas que se encuentran en el pensamiento de Hadjadj a los núcleos esenciales del movimiento transhumanista, interpretándolas como desarrollos que continúan y profundizan las ya realizadas por autores como Jürgen Habermas y Michael Sandel; además, pretendo mostrar que son plausibles, tienen consideraciones convincentes y una nueva forma de pensar y responder al transhumanismo. La estructura está dividida en tres partes: 1) la exposición de los argumentos y crítica que Hadjadj hace a esta postura filosófica basándome en las liberaciones de nuestras limitaciones antes mencionadas; 2) centrarme en la propuesta que hace para superar esta postura, cómo complementa las críticas que hacen Habermas y Sandel desde una perspectiva metafísica; y, por último, 3) la defensa del ser humano desde su visión basada en sus “cuatro vueltas”. (shrink)

The modern obsession with safety (which ranges from extreme fear of germs to xenophobia) ends in isolation. In this paper, we explore what is behind of this concern with safety, the metaphors that surround it (which come from immunology), and a way to escape from fear using the Deleuzian idea of nomadic ethics as a point of departure. From a contemporary perspective of how immune systems work, we rethink the metaphors used to describe it: as far as new characterizations of (...) immunity arise, there is a need to approach a notion of non-defensive, non-reactive answers to the ever-changing demands of a world in motion, of becoming. It implies rethinking alterity, the need to embrace it instead of avoiding it, and the need to understand its importance, the way in which it makes us humans. We will argue that nomadic ethics require a nomadic epistemology, an acknowledgement that a full understanding and control of reality may be beyond our reach, and therefore an acceptance of partial, tentative, and diverse forms of knowledge. (shrink)

ABSTRACT The modern obsession with safety (which ranges from extreme fear of germs to xenophobia) ends in isolation. In this paper, we explore what is behind of this concern with safety, the metaphors that surround it (which come from immunology), and a way to escape from fear using the Deleuzian idea of nomadic ethics as a point of departure. From a contemporary perspective of how immune systems work, we rethink the metaphors used to describe it: as far as new characterizations (...) of immunity arise, there is a need to approach a notion of non-defensive, non-reactive answers to the ever-changing demands of a world in motion, of becoming. It implies rethinking alterity, the need to embrace it instead of avoiding it, and the need to understand its importance, the way in which it makes us humans. We will argue that nomadic ethics require a nomadic epistemology, an acknowledgement that a full understanding and control of reality may be beyond our reach, and therefore an acceptance of partial, tentative, and diverse forms of knowledge. RESUMEN La obsesión moderna por la seguridad (desde el miedo extremo a los gérmenes hasta la xenofobia) termina en el aislamiento. En este artículo exploramos qué hay detrás de esta preocupación por la seguridad, las metáforas que la rodean (y que provienen de la inmunología) y una forma de escapar del miedo tomando como punto de partida la idea deleuziana de la ética nómada. Desde una perspectiva contemporánea de cómo funcionan los sistemas inmunológicos, repensamos las metáforas: en la medida en que surgen nuevas caracterizaciones de la inmunidad, existe la necesidad de aproximarnos a las respuestas no defensivas, no reactivas a las demandas del devenir. Implica repensar la alteridad, la necesidad de abrazarla en lugar de evitarla, y su importancia para entender lo que nos hace humanos. Argumentaremos que la ética nómada requiere una epistemología nómada, un reconocimiento de que una comprensión y un control plenos de la realidad pueden estar fuera de nuestro alcance y, por lo tanto, una aceptación de formas de conocimiento parciales, tentativas y diversas. (shrink)

This paper deals with the mental processes of authoritarians. Firstly, we explore these processes from the perspective of the type of metaphors authoritarians embody; we understand those metaphors as a conceptual framework that configurates human thought. This framework is understood as social constructs which are incorporated in the individual as a social being. We inquire about some frameworks to which the authoritarian thought appeals. One of them is the framework of the family, and the father as the main figure, which (...) explains hierarchical relations. Another one is the friend-enemy dualism: through this, authoritarian identity establishes intersubjective relations that correspond to a Manichean vision of the world: friends are those who agree with the metaphors that the authoritarian embodies, enemies are the others. Thus, the authoritarian conceives him or herself as a hero, and so this figure allows us to understand certain imaginaries and their relationship with a personal objective: such an objective ceases to be individual to be the goal of the collective, and the authoritarian person proclaims him or herself as the guarantor of its achievement. Finally, after studying frameworks as social constructs we proceed to inquire about the character of the authoritarian person as a symptom of a particular constitution of identity. Such a constitution reminds us of the figure of the successful psychopath, whose identity is shaped by inflexible agendas and an outlook on the world that even put his or her own integrity at risk. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Del maestro Fernando González Ochoa se han dicho y escrito muchas cosas. Se le hatildado de ateo, rebelde, mal hablado; pero se olvida que fue un místico que buscó llegara una comunión con la Intimidad, un hombre amante de la vida; se olvida sulabor de maestro de escuela que quiso formar hombres auténticos, sacándolos de suvida de rebaño y dándoles el lugar que se merecen. El presente trabajo tiene como objetivo,a partir de la lectura de algunas de sus obras, indagar (...) sobre el pensamientoantropológico y educativo del maestro Fernando González Ochoa. Presento al lector alFernando González que encontré a lo largo de mi lectura de sus obras y del diversomaterial consultado para este trabajo. He sido lo más fiel posible a su pensamiento,realizando una actividad hermenéutica en la que busco presentar la comprensión propiadel autor ante el contexto que le tocó vivir, el cual le sirvió de pretexto para escribir sustextos. (shrink)