Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...) Our article introduces EE into bioethics by translating knowledge from science to ethics and by comparing the risks of EE with those of GE. We, first (I), make the case that a broader ethical debate on EE is due, provide scientific background on EE, compile potential use-cases and recap previous debates. We then (II) compare EE and GE and suggest that the severity of risks of novel gene technologies depends on three factors: (i) the choice of an ex vivo versus an in vivo editing approach, (ii) the time of intervention and intervention windows and (iii) the targeted diseases. Moreover, we show why germline EE is not effective and reject the position of strong epigenetic determinism. We conclude that EE is not always ethically preferable to GE in terms of risks, and end with suggestions for next steps in the current ethical debate on EE by briefly introducing ethical challenges of new areas of preventive applications of EE (III). (shrink)

These volumes will serve as useful resources for anyone interested in philosophy of color perception or color science.

Intersubjectivity refers to the variety of possible relations between perspectives. It is indispensable for understanding human social behaviour. While theoretical work on intersubjectivity is relatively sophisticated, methodological approaches to studying intersubjectivity lag behind. Most methodologies assume that individuals are the unit of analysis. In order to research intersubjectivity, however, methodologies are needed that take relationships as the unit of analysis. The first aim of this article is to review existing methodologies for studying intersubjectivity. Four methodological approaches are reviewed: comparative self-report, (...) observing behaviour, analysing talk and ethnographic engagement. The second aim of the article is to introduce and contribute to the development of a dialogical method of analysis. The dialogical approach enables the study of intersubjectivity at different levels, as both implicit and explicit, and both within and between individuals and groups. The article concludes with suggestions for using the proposed method for researching intersubjectivity both within individuals and between individuals and groups. (shrink)

Slightly modified excerpt from the section 13.4 Zusammenfassung und Ausblick (translated into englisch): This chapter is based on an analysis of ethical debates on epigenetics and genome editing, debates, in which ethical arguments relating to future generations and justice play a central role. The analysis aims to contextualize new developments in genetic engineering, such as genome and epigenome editing, ethically. At the beginning, the assumptions of "genetic determinism," on which "genetic essentialism" is based, of "epigenetic determinism" as well as "genetic" (...) and "epigenetic exceptionalism" are analyzed and critically discussed. The remarks on the ethical discourse on epigenetics show that the notion of "epigenetic determinism" can sometimes be discerned not only in popular scientific discourse but also in ethical discourse. Ethical debates on epigenetics, however, have distanced themselves from this deterministic understanding. As a result, the focus in the ethical discourse on epigenetics shifts from responsibility for one's own health and that of subsequent generations to justice. What is meant here is justice, for example, in terms of access to healthy environmental conditions, regardless of whether these contribute to health with or without epigenetic agency. An analysis of the discourse on genome editing reveals that it is primarily germline interventions that are being ethically examined, with a concentration on the aspect of inheritance. The question is whether this is accompanied by an implicit "genetic determinism" or even a "genetic essentialism": the determinism could lie in the centrality of the aspect of heritability, since only genetic information is inherited. Does the aspect of heritability and genome modification play a more decisive role in debates on genome editing than the safety issue? Is the problem of embryos and their potential offspring not being able to consent to germline intervention given such a high priority because it is a genetic intervention? Under such a premise of "strong genetic determinism" supplemented by "epigenetic determinism," not only genome editing but also epigenome editing would be ethically relevant precisely because it too would have an influence on the genome. How this influence of genome editing and epigenome editing is ethically evaluated in each case therefore depends initially on whether the assumptions of "genetic" and "epigenetic determinism" are advocated. These assumptions are increasingly viewed critically in ethical discourse because they cannot be confirmed from a scientific perspective. In popular scientific debates in particular, however, they seem to persist, which ultimately also influences the public discussion. Since a broad public discussion is required especially on genome editing, a reflective approach to the various "-isms" analyzed in this chapter is central. DOI: 10.5771/9783748927242. (shrink)

Palmer's subjectivity barrier seems to be erected on a popular but highly suspect conception of visual experience, and his color room argument is invalid.

Saul Kripke’s much discussed Wittgenstein on Rules and Private Language has, I believe, been widely misinterpreted. The purpose of this note is to offer a correction. As it happens, on my reading of Kripke’s text Kripke’s Wittgenstein begins to look recognisably like Wittgenstein himself. But I shall not be concerned here with the question of whether Kripke’s Wittgenstein is Wittgenstein. My only aim is to correct the misinterpretation.

This paper presents methodological reflections on power sharing and shifts of power in various interview situations. Narratives are said to be shaped by our attempts to position ourselves within social and cultural circumstances. In an interview situation, power can be seen as something that is created and that shifts between the interviewer and the interviewed. Reflexivity is involved when we as interviewers attempt to look at a situation or a concept from various perspectives. A modified form of discourse analysis inspired (...) by subject positioning was used to reflect on power relations in four different interview situations. The analyses indicate that reflection on the power relations can lead to other forms of understanding of the interviewee. The main conclusion that can be drawn from this study is that power relations are created within an interview situation and therefore it is important to be aware of dominant perspectives. Researchers and nurses face the challenge of constantly raising their level of consciousness about power relationships, and discursive reflexivity is one way of doing this. Thus, reflexivity is an important part of the qualitative research process. (shrink)

Commonly we distinguish the strike of a match, as a cause of the match lighting, from the presence of oxygen, as a mere condition. In this paper I propose an account of this phenomenon, which I call causal selection. I suggest some reasons for taking causal selection seriously, and indicate some shortcomings of the popular contrastive approach. Chief among these is the lack of an account of contrast choice. I propose that contrast choice is often just the counterfactual scenario in (...) which the effect does not occur: I suggest that if c causes e , then if e hadn't occurred, c wouldn't have occurred. I argue that this is a necessary condition on causation which causes meet but mere conditions fail. (shrink)

TheCatalogue of Scientific Papers, published by the Royal Society of London beginning in 1867, projected back to the beginning of the nineteenth century a novel vision of the history of science in which knowledge was built up out of discrete papers each connected to an author. Its construction was an act of canon formation that helped naturalize the idea that scientific publishing consisted of special kinds of texts and authors that were set apart from the wider landscape of publishing. By (...) recovering the decisions and struggles through which theCataloguewas assembled, this essay aims to contribute to current efforts to denaturalize the scientific paper as the dominant genre of scientific life. By privileging a specific representation of the course of a scientific life as a list of papers, theCataloguehelped shape underlying assumptions about the most valuable fruits of a scientific career. Its enumerated lists of authors’ periodical publications were quickly put to use as a means of measuring scientific productivity and reputation, as well as by writers of biography and history. Although it was first conceived as a search technology, this essay locates theCatalogue’s most consequential legacy in its uses as a technology of valuation. (shrink)

An account of Aristotle's syllogistic (including a full square of opposition and allowing for empty nouns) as an integral part of first-order predicate logic is lacking. Some say it is not possible. It is not found in the tradition stemming from ukasiewicz's attempt nor in less formal approaches such as Strawson's. The ukasiewicz tradition leaves Aristotle's syllogistic as an autonomous axiomatized system. In this paper Aristotle's syllogistic is presented within first-order predicate logic with special restricted quantifiers. The theory is not (...) motivated primarily by historical considerations but as an accurate account of categorical sentences along lines suggested by recent work on natural language quantifiers and themes from supposition theory. It provides logical forms which conform to grammatical ones and is intended as a rival to accounts of quantifiers in natural language that appeal to binary quantifiers, for example, Wiggins or to restricted quantifiers, for example, Neale. (shrink)

The revival of classical liberal thought has reignited a debate about economic freedom and social justice. Classical liberals claim to defend expansive economic freedom, while their critics wish to restrict this freedom for other values. However, there are two problems with the role ‘economic freedom’ plays in this debate: inconsistency in the use of the concept and indeterminacy with respect to its definition. Inconsistency in the use of the concept ‘freedom’ has mistakenly made a certain kind of ‘left-wing’ critique of (...) poverty, and of markets generally, appear to be a concern with inequality in means to enjoy freedom, not with freedom itself. Indeterminacy about which beings and doings the basic liberties protect misrepresents the left-wing position as about something other than economic freedom. Inconsistency and indeterminacy lead to artificial narrowness in current debates and to a failure to see that disagreement is based not just on moral differences but also on conceptual confusion. This confusion leads both classical liberals and their critics to claim more than they may legitimately do, and to ignore a position that accepts the standard of definition of freedom but arrives at different institutional conclusions about what secures that freedom. (shrink)

I argue here that the impairment principle requires clarification. It needs to explain what makes one impairment greater than another, otherwise we will be unable to make the comparisons it requires, the ones that enable us to determine whether b really is a greater impairment than a, and as a result, whether causing b is immoral because causing a is. I then develop two of what I think are the most natural accounts of what might make one impairment greater than (...) another. The quantitative understanding of greater impairment is problematic because it leaves the impairment principle vulnerable to counterexamples; just because impairment b impairs a larger number of abilities or the same number of abilities but for a longer period or to a higher degree does not mean that b is a greater impairment than a. The qualitative understanding of greater impairment is problematic because it does not explain examples of greater impairment used in the literature, means that an abortion is always a qualitatively more severe impairment than causing fetal alcohol syndrome regardless of how the organism is affected, and/or entails that lethal impairment is always greater than nonlethal impairment. (shrink)

I argue that we should rethink the nature and scope of Spinoza’s “one and the same” relation. Contrary to the standard reading, the nature of this relation is not identity but a union, and its scope includes all idea-object pairs, even God and the idea of God. A crucial reason we should adopt this dual picture is that the idea of God must be one and the same as something found when Nature is conceived under each of the other attributes. (...) If “one and the same” is interpreted as a relation of identity, this requirement cannot be met. However, maintaining that God and the idea of God are one and the same not only fulfills this requirement, but also is independently motivated. I also briefly consider how the thesis that God and the idea of God are one and the same affords us with positive insights concerning the nature of this relation. (shrink)

If there is any value in the idea that disease is something other than the mere absence of health then that value must lie in the way that diseases are classified. This paper offers further development of a view advanced previously, the 'contrastive model' of disease: it develops the account to handle asymptomatic disease ; and in doing so it relates the model to a broadly biostatistical view of health. The developments are prompted by considering cancers featuring viruses as prominent (...) causes, since these appear to amount to cases where the prescriptions of the contrastive model could be followed, but aren't. The resulting irrelevance objection claims that the contrastive model is irrelevant to medical science and practice. The paper seeks to rebut the irrelevance objection. (shrink)

Within the history of African American struggle against racist oppression that often verges on dystopia, a hidden tradition has depicted a transfigured world. Daring to speculate on a future beyond white supremacy, black utopian artists and thinkers offer powerful visions of ways of being that are built on radical concepts of justice and freedom. They imagine a new black citizen who would inhabit a world that soars above all existing notions of the possible. In Black Utopia, Alex Zamalin offers (...) a groundbreaking examination of African American visions of social transformation and their counterutopian counterparts. Considering figures associated with racial separatism, postracialism, anticolonialism, Pan-Africanism, and Afrofuturism, he argues that the black utopian tradition continues to challenge American political thought and culture. Black Utopia spans black nationalist visions of an ideal Africa, the fiction of W. E. B. Du Bois, and Sun Ra’s cosmic mythology of alien abduction. Zamalin casts Samuel R. Delany and Octavia E. Butler as political theorists and reflects on the antiutopian challenges of George S. Schuyler and Richard Wright. Their thought proves that utopianism, rather than being politically immature or dangerous, can invigorate political imagination. Both an inspiring intellectual history and a critique of present power relations, this book suggests that, with democracy under siege across the globe, the black utopian tradition may be our best hope for combating injustice. (shrink)

In this paper I discuss the dialogues between 'Protagoras', Theodorus and Socrates in "Theaetetus" 161-171 and emphasise the importance for this passage of a dilemma which refutation is shown to pose for relativism at 161e-162a. I argue that the two speeches delivered on Protagoras' behalf contain material that is deeply Socratic and suggest that this feature of the speeches should be interpreted as part of Plato's philosophical case against relativism, reflecting the relativist's own inability to defend his theory from attempts (...) to refute it. I then discuss Theodorus' role in the refutation of Protagoras and argue that his voice is needed to get relativism disproved in the self-refutation argument of 171a-c. I conclude with a brief discussion of the image of Protagoras at 171d. (shrink)

The emergence of a new tissue economy raises issues for the governance of risk and concepts of the body and self. This article explores the development of autologous cell therapies as a form of tissue engineering and considers how and why autologous applications are seen as less risky and more socially and politically acceptable. In a careful analysis of contemporary debates around the need for new international policies to regulate these technologies, we critically assess the discursive strategies employed to support (...) ideas of the body as a natural entity. Central to these debates are assumptions that autologous applications do not threaten the moral or corporeal integrity of the individual and that they are ‘an ethics-free zone’. Analysis reveals that concepts such as intercorporeality need to be refined if they are to assist our understanding of these cell-based therapies. We consider the biopolitics of Autologous Chondrocyte Implantation (ACI) in order to show the linkages between the culturing of cells, regulation and the reproduction of the self. (shrink)

Recent years have seen a revival of interest in Michael Walzer's doctrine of ‘supreme emergency’. Simply put, the doctrine holds that, when a state confronts an opponent who threatens annihilation, it can be morally legitimate to violate one of the cardinal rules of the war convention – the principle of non-combatant immunity. Walzer cites the case of Britain's decision to bomb German cities in 1940 as a case in point. Although the theory of supreme emergency has been scrutinised, the historical (...) case that Walzer refers to has not been looked at in depth. This article seeks to remedy this problem by asking whether the principle actors involved in the decision to bomb German cities understood themselves to be in a supreme emergency. It argues that the British leadership never openly admitted that they were in fact targeting German civilians, and that the principle reason for this was a widespread belief that the British and American publics would not support such a campaign. As a result, throughout the war, the British government publicly maintained the fiction that the devastation of German cities was a collateral product of attacks on its industrial infrastructure. This, in turn, suggests that liberal societies – even those facing imminent destruction – do not tend to support a relaxing of the rules of non-combatant immunity, suggesting that the prohibition on deliberately killing non-combatants may be more embedded than has hitherto been thought. (shrink)

Scholars have paid little attention to the classifications among goods that Epicureans posit. This paper remedies that deficiency. I argue for three claims. First, if we take instrumental goods to be those that are a means or causally lead to the intrinsic good and we take constitutive goods to be those that are part of or amount to the intrinsic good, then the Epicureans probably took reverence for a wise man and wisdom to be instrumental goods but self-sufficiency and phronesis (...) to be constitutive goods. Second, Epicurean personal goods are those that produce eudaimonia but are firmly up to us to achieve rather than owing to chance. Third, Epicurean immortal goods are those that bring about divinely resilient tranquility for those who cultivate them. I then show how positing these classifications enables the Epicureans to claim that godlike happiness is achievable through our own efforts no matter the external circumstances. (shrink)

It is claimed that misrepresentations of Yogācāra Buddhism appeared in older and later works in India, and then in European and other scholarship. The thesis that Yogācāra denies external existence is rejected, the defense being this Buddhist system's own response. Two major sections divide the argument: (1) The Position of the Yogācārins and (2) Three Clarifications of the Position.

G&S describe the radical neuron doctrine in a number of slightly different ways, and we think this hides an important distinction. On the one hand, the radical neuron doctrine is supposed to have the consequence "that a successful theory of the mind will make no reference to anything like the concepts of linguistics or the psychological sciences as we currently understand them", and so Chomskyan linguistics "is doomed from the beginning" (sect. 2.2.2, paras. 2,3).[1] (Note that `a successful theory' must (...) be read as `any successful theory', else the inference will fail.) On the other hand, the radical neuron doctrine is said to be the claim "that emergent psychological properties can be explained by low-level neurobiological properties" (sect. 2.3, para. 3). It is clear from the context that this can be more faithfully rendered as: psychological phenomena can be explained in (solely) neurobiological terms. But this formulation of the doctrine does not have the consequence just mentioned. (shrink)

Scholars are increasingly concerned about social biases in facial analysis systems, particularly with regard to the tangible consequences of misidentification of marginalized groups. However, few have examined how automated facial analysis technologies intersect with the historical genealogy of racialized gender—the gender binary and its classification as a highly racialized tool of colonial power and control. In this paper, we introduce the concept of auto-essentialization: the use of automated technologies to re-inscribe the essential notions of difference that were established under colonial (...) rule. We consider how the face has emerged as a legitimate site of gender classification, despite being historically tied to projects of racial domination. We examine the history of gendering the face and body, from colonial projects aimed at disciplining bodies which do not fit within the European gender binary, to sexology's role in normalizing that binary, to physiognomic practices that ascribed notions of inferiority to non-European groups and women. We argue that the contemporary auto-essentialization of gender via the face is both racialized and trans-exclusive: it asserts a fixed gender binary and it elevates the white face as the ultimate model of gender difference. We demonstrate that imperialist ideologies are reflected in modern automated facial analysis tools in computer vision through two case studies: commercial gender classification and the security of both small-scale and large-scale spaces. Thus, we posit a rethinking of ethical attention to these systems: not as immature and novel, but as mature instantiations of much older technologies. (shrink)

New challenges are constantly emerging in the social sector in South Africa. Various social (non-profit) organisations are developing new and innovative ways to accommodate these challenges and to meet social needs. The aim of this research article is to measure the current social innovation capacity of the Dutch Reformed Church (DR Church), with reference to innovation capabilities, to determine at what level the church is meeting new social needs. Semi-structured interviews were conducted to collect data from six different congregations and (...) a governing body in the Pretoria area, South Africa, was included. Twelve participants were interviewed between August and October 2017. The participants, consisting of ministers and board members, each held a management position. The social innovation capacity measurement of the DR Church showed that the organisation was successfully developing new ways to serve as a social agent in society. There are obstacles that prohibit the DR Church from developing new innovative ways to meet the social needs of its society, for example, entrepreneurial, developmental and leadership change capacities. Recommendations are made to maximise social innovation capacity of the managers (ministers and board members). (shrink)

The article concerns a mediaeval Indian debate over whether, and if so how, we can know that a self exists, understood here as a subject of cognition that outlives individual cognitions, being their common substrate. A passage that has not yet been translated from Sanskrit into a European language, from Jayanta Bhaṭṭa’s Nyāyamañjarī, ‘Blossoms of Reasoning’, is examined. This rich passage reveals something not yet noted in secondary literature, namely that Mīmāṃsakas advanced four different models of what happens when the (...) self perceives itself. The article clarifies the differences between the four, and the historical and logical relationships between them. It also hypothesizes pressures that constituted the need for the creation of the newer views, i.e. perceived problems with the earlier views, which the proponents of the newer views saw themselves as overcoming. (shrink)

A term td is called a ternary deductive term for a variety of algebras V if the identity td≈r holds in V and ∈θ yields td≈td for any A∈V and any principal congruence θ on A. A connective f is called td-distributive if td)≈ f,…,td). If L is a propositional logic and V is a corresponding variety that has a TD term td, then any admissible in L rule, the premises of which contain only td-distributive operations, is derivable, and the (...) substitution r↦td is a projective L-unifier for any formula containing only td-distributive connectives. The above substitution is a generalization of the substitution introduced by T. Prucnal to prove structural completeness of the implication fragment of intuitionistic propositional logic. (shrink)

ABSTRACT Reading the work of Sylvia Wynter and María Lugones together, particularly as it pertains to sex, gender, and sexuality, reveals the limits of popular discourses and frameworks of queer and feminist philosophy that may unwittingly obscure its constructions of sex and gender along the global color line. This article looks at Wynter’s analysis of gender as a category differentially applied across the global color line and Lugones’s analysis of the coloniality of gender. The author concludes to move beyond the (...) coloniality of gender requires intersex liberation, but also that intersex liberation must be understood within a decolonial framework. (shrink)

The American Journal of Bioethics, Volume 11, Issue 6, Page 55-57, June 2011.

Philippe van Parijs (2003) has argued that an egalitarian ethos cannot be part of a post- Political Liberalism Rawlsian view of justice, because the demands of political justice are confined to principles for institutions of the basic structure alone. This paper argues, by contrast, that certain principles for individual conduct—including a principle requiring relatively advantaged individuals to sometimes make their economic choices with the aim of maximising the prospects of the least advantaged—are an integral part of a Rawlsian political conception (...) of justice. It concludes that incentive payments will have a clearly limited role in a Rawlsian theory of justice. (shrink)

This paper takes as its starting point an examination of the current status of some of the concerns that were raised in the mid?1980s about methodological problems faced by educational researchers using the behavioural approach in schools. These concerns included the measurement of agreement between observers, the interpretation of raw data extracted, the potential influences of observers and the inherent properties of research designs. Subsequently, some more wide?ranging concerns are considered, in particular the kinds of behaviour selected for treatment, the (...) lack of analysis of what is involved in teachers? positive responses to pupils? behaviour and the relatively uninvestigated effects of teachers? negative responses. The conclusions are presented as a series of points that are listed, as far as possible, in the order in which they confront the investigator. (shrink)

(2006). Confronting a World without Justice: Brian Barry’s Why Social Justice Matters. Critical Review of International Social and Political Philosophy: Vol. 9, No. 3, pp. 461-472.

A popular interpretation of linguistic theories has it that they should describe the brain at a high level of abstraction. One way this has been understood is as the requirement that the theory’s derivational structure reflect (by being isomorphic to) relevant structural properties of the language user’s brain. An important criticisrn of this idea, made originally by Crispin Wright against Gareth Evans in the 1980s, still has purchase, notwithstanding attempts to reply to it, notably by Martin Davies and, indirectly, Christopher (...) Peacocke. Wright’s objection seems to have been forgotten rather than seen off. (shrink)