Abstract: This working paper focuses on the question whether there is a therapeutic imperative that, in specific situations, would oblige us to perform genome editing at the germline level in the context of assisted reproduction. The answer to this central question is discussed primarily with reference to specific scenarios where preimplantation genetic diagnosis (PGD) does not represent an acceptable alternative to germline genome editing based on either medical, or ethical, or – from the perspective of the potential parents – moral (...) or religious grounds. This article deals with four different types of case constellations that result from these possible reasons against PGD as well as from the necessity or dispensability of a subsequent “control PGD.” These cases are discussed based on hypotheses concerning contextual factors and theoretical assumptions. In conclusion, we point out that if our assumptions are correct, there is probably no therapeutic imperative for genome editing at the germline level. We draw this rationale from the fact that germline interventions are likely not person-affecting. However, we caution the reader that our result is preliminary and needs to be more carefully examined in future work in light of the bioethical debate and potential objections. -/- // Abstract: Im Zentrum dieses Working Papers steht die Frage, ob es einen therapeutischen Imperativ geben kann, der uns, in bestimmten Situationen, verpflichten würde, eine Genomeditierung (genome editing) auf Keimbahnebene im Rahmen der assistierten Befruchtung vorzunehmen. Die Antwort auf diese zentrale Frage wird insbesondere mit Bezug auf Fälle diskutiert, in denen das Verfahren der Präimplantationsdiagnostik (PID) keine aus entweder medizinischen oder ethischen oder – aus Sicht der potentiellen Eltern – moralischen bzw. religiösen Gründen akzeptable Alternative zu einem Keimbahneingriff darstellt. Die möglichen Gründe gegen die PID sowie die Erforderlichkeit oder Verzichtbarkeit einer nachfolgenden «Kontroll-PID» ergeben vier verschiedene Fallkonstellationen, denen sich der Beitrag zuwendet. Auf Grundlage von Hypothesen zu kontextuellen Faktoren und theoretischen Annahmen diskutieren wir diese Fälle. Im Ergebnis verweisen wir darauf, dass es, wenn unsere Annahmen zutreffen, vermutlich keinen therapeutischen Imperativ zum genome editing auf Keimbahnebene gibt. Dies begründet sich daraus, dass der Keimbahneingriff vermutlich nicht als personenbezogen (person-affecting) zu bezeichnen ist. Wir weisen jedoch darauf hin, dass unser Ergebnis vorläufig ist und unter Berücksichtigung der bioethischen Debatte und möglicher Einwände genauer geprüft werden muss. -/- // Résumé: Ce Working Paper se concentre sur la question de l’existence d’un impératif thérapeutique qui, dans des situations spécifiques, nous obligerait à réaliser une édition du génome au niveau de la lignée germinale dans le cadre de la procréation assistée. Afin de répondre à cette question centrale nous développons quatre scénarios spécifiques dans lesquels le diagnostic préimplantatoire (DPI) ne représente pas une alternative acceptable à l’édition du génome germinal pour des raisons médicales, éthiques ou – du point de vue des futurs parents – morales ou religieuses. Cet article traite de quatre constellations différentes de cas résultant des raisons mises en avant pour s'opposer au DPI ainsi que de la nécessité ou de l’inutilité d’un ultérieur « DPI de contrôle » Ces cas sont discutés sur la base d’hypothèses portant sur les facteurs contextuels et sur les présupposés théoriques. En conclusion, nous soulignons que si nos hypothèses sont correctes, il n’y a probablement aucun impératif thérapeutique justifiant l’édition du génome au niveau de la lignée germinale. Nous arrivons à cette conclusion parce qu’une intervention au niveau de la lignée germinale n’est probablement pas susceptible d’affecter la personne. Cependant, nous mettons en garde le lecteur sur le fait que notre conclusion est préliminaire et qu’elle doit être examinée avec soin dans des futurs travaux instruits par le débat bioéthique et par les éventuelles objections. (shrink)

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In order for the so-called strengthened impairment argument to succeed, it must posit some reason R that causing fetal alcohol syndrome is immoral, one that also holds in cases of abortion. In formulating SIA, Blackshaw and Hendricks borrow from Don Marquis to claim that the reason R that causing FAS is immoral lies in the fact that it deprives an organism of a future like ours. I argue here that SIA fails to show that it is immoral to cause FAS (...) and abort fetuses that will not be born because it deprives them of an FLO. This is because fetuses that will not be born have no chance of having an FLO in the first place, so causing FAS for and aborting them cannot deprive them of one. I then consider three responses to my argument. I conclude that each fails. SIA does not accomplish its task of showing why it is immoral to impair fetuses that will not be born. Perhaps it can accomplish the task of showing why it is immoral to impair fetuses that will be born, but not without sacrificing at least some of its alleged significance. (shrink)

This fascinating and thought-provoking book provides much-needed philosophical background for counselors, therapists, and healthcare workers looking for broader, deeper foundations in the struggle to help and make sense of others. While examining the best among 20th century philosophy it shows the wealth of inspiration of earlier centuries, and demonstrates with remarkable clarity the way in which the ideas of, and the relations between, these philosophers can inspire, inform, and underpin much of counseling and psychotherapy.

This paper introduces a symposium on Equality versus Priority. It explains how cases involving risk are key to distinguishing these views and discusses a 'social egalitarian' critique of both 'telic egalitarians' and 'telic prioritarians'.

How should the international community respond when states commit atrocity crimes against sections of their own population? In practice, international responses are rarely timely or decisive. To make matters worse, half-hearted or self-interested interventions can prolong crises and contribute to the growing toll of casualties. Recognizing these brutal realities, it is tempting to adopt the fatalist view that the best that can be done is to minimize harm by letting the state win, allowing the status quo power structure to persist. (...) Indeed, this is how many commentators and states have responded to the tide of human misery in Syria. Could a policy of letting the state perpetrator prevail be a viable alternative to other options, including military intervention? This essay suggests not. It explains the logic behind the fatalist approach and shows that problems of recurrence, precedence, and rights mean that such an approach cannot offer a plausible alternative to measures designed to resist and increase the costs of committing atrocity crimes. (shrink)

For as long as humans have fought wars, we have been beguiled and frustrated by the prospect of world peace. Only a very few of us today believe that world peace is possible. Indeed, the very mention of the term “world peace” raises incredulity. In contrast, as part of the roundtable “World Peace (And How We Can Achieve It),” this essay makes the case for taking world peace more seriously. It argues that world peace is possible, though neither inevitable nor (...) irreversible. World peace, I argue, is something that every generation must strive for, because the ideas, social structures, and practices that make war possible are likely to remain with us. The essay proceeds in three parts. First, I briefly set out what I mean by peace and world peace. Second, I explain why I think that world peace is possible. Third, I examine how the world might be nudged in a more peaceful direction. (shrink)

We contend that a very seductive argument for theological fatalism fails. In the course of our discussion we point out that theological fatalism is incompatible with the existence of a being who is omnipotent, omniscient and infallible. We suggest that ‘possible’ formalized as ‘◊’ is to be understood as ‘can or could have been’ and not simply as ‘can’. The argument we discuss conflates the two. We end by rounding out, hope-fully, some left over corners of serious concern to the (...) theist. (shrink)

The term ‘coherence’ (and its antonym ‘incoherence’) is used in a bewildering variety of ways in epistemology (and in philosophy more broadly). This entry attempts to bring some discipline to uses of the term by offering a taxonomy of notions of coherence (and incoherence), and then surveying which of the resulting notions is (or should be) at work in the various different contexts in which it is deployed.

Migrants invariably and unavoidably experience domination under the nation-state centered concepts, categories, and institutions that structure our political thinking. In response, we need to build new forms of citizenship, including local, regional, transnational, and supranational forms of belonging, accompanied by meaningful, democratic, political power. In this paper, I examine historical and present-day alternative models of political organization as possible viable alternatives to state-centric liberal democracy. It begins the task of assessing these models using radical republican theory that grounds non-domination in (...) the active and equal participation of people subject to power.I have three broad aims. First, we need to break down the native-migrant dichotomy to highlight commonalities and search for solidarities among migrants and other marginalized and oppressed groups, including indigenous groups. Second, I seek to awaken the political imagination. Many people do not believe there are viable alternatives to liberal democracy centered around the nation-state. In response, we should draw attention to the ways in which the nation-state’s hegemony is fragile and fragmented and the ways in which sovereignty is complex and contested. Most importantly, we need to consider alternative models for inspiration. Third, we need tools for assessing the desirability of alternatives and for building new forms of citizenship.In what follows, first I explain why the dominant, nation-state centered model of political organization is unable to deliver justice in today’s world, or, indeed, address the collective dangers that humanity faces. I next provide a sketch of a radical republican vision that provides normative guidance our thinking about alternative institutions. I end by using this radical republic vision to reflect on possibilities to guide efforts to remake the world. (shrink)

I present a puzzle for the standard, propositional semantic account of belief reports by considering novel inferences which it incorrectly predicts to be invalid under assumptions that are plausible by its advocates’ own lights. In response, I propose a conservative departure from the standard view on which certain ‘that’-clauses designate novel devices of semantic type that I call open propositions. After outlining some desiderata for a theory of open propositions, I provide some reasons for advocates of the standard view to (...) treat them as properties of a certain kind. Then I give a bridge principle between the core notions of belief and belief-about before showing how the resulting view can be implemented in accordance with formal theories of syntax and semantics. I bring out some of the consequences this investigation has beyond our semantic theorizing and conclude, more generally, that any response to the puzzle requires paying some surprising cost or another. (shrink)

The key claims of left accelerationism are grounded upon a network of concepts. Crucial here have been the notions of hegemony ; strategy ; and rationality. Though the concepts of hegemony–strategy and strategy–rationality have received wide treatment, the hegemony and rationality pair has received minimal attention. Yet to render the core arguments of left accelerationism explicable requires that these three ideas are placed in some concrete relation. To put the issue another way: what is the relationship between power and rationality? (...) This article will argue that many of the critiques which the left accelerationist position has received are bound up in misunderstanding this relationship. To remedy such misnomers, we will argue that it is a more sophisticated understanding of strategy that can help bridge these two domains. This leads us to delineate a form of strategy-without-a-strategiser, a distributed and emergent strategic orientation which mediates the power/rationality binary. (shrink)

An important motivation for believing in the modal realist’s ontology of other concrete possible worlds and their inhabitants is its theoretical utility, centrally the reduction of ordinary modal talk to counterpart theory as showcased by David Lewis’s 1968 translation scheme. In a recent paper Harold Noonan, following the lead of John Divers, argues that Lewis’s scheme is not strictly adequate by the modal realist’s own lights, and that nothing short of jettisoning de dicto contingency will help. In this paper, I (...) argue that this is a serious overreaction. First, I show that Noonan’s problem does not touch Lewis’s proposal, since his translation scheme is not even concerned with the relevant sentences. Thus, Noonan’s problem only points to a limit in scope. I then go on to propose a straightforward extension of the translation scheme that provides translations for the allegedly problematic sentences, but does so endangering neither adequacy nor de dicto contingency. (shrink)

Through a reading of Kant’s essay, “An Old Question Raised Again: Is the Human Race Constantly Progressing?”, I argue that Kant’s political philosophy fails to adequately engage with the political event in itself, and that Kant’s so-called political writings only provide a theory of the social sphere. First, I present the Kantian political subject as an antinomy between the metaphysically grounded spectator and the physically situated actor. Second, I show that Kant tries to solve the antinomy between the actor and (...) the spectator by attributing primacy to the judgement of the spectator. Third, I show that this move fails because it removes from political judgment what ultimately defines the political, i.e. plurality, spontaneity, and action. I conclude that rather than a theory of the sphere of political life, what Kant achieves is the thinking out of a theory of society (Gesellschaft). (shrink)

This paper explores relational syllogistic logics, a family of logical systems related to reasoning about relations in extensions of the classical syllogistic. These are all decidable logical systems. We prove completeness theorems and complexity results for a natural subfamily of relational syllogistic logics, parametrized by constructors for terms and for sentences.

From Indra’s Net to Internet: Communication, Technology, and the Evolution of Buddhist Ideas, by Daniel Veidlinger. Honolulu: University of Hawai’i Press, 2018. 273pp. Hb $68. ISBN-13: 9780824873400.

Este ensaio pretende analisar a situação atual de confinamento imposta pela pandemia de Covid-19 a partir dos conceitos heideggerianos de técnica, quotidiano e preocupação. Defendemos que o isolamento oferece as condições materiais para que mais pessoas deem atenção a si mesmas e cuidem de se mesmas, do que resulta um deixar-ser tanto a própria liberdade quanto a do outro. Com isso, as possibilidades que somos são encaradas como tais, em especial nosso ser-para-a-morte.

This volume draws on an expanded field of bioethical, sociological and anthropological research, to set a new agenda for discussing the ethics of disclosing prognostic genetic information.

This paper develops an update semantics for weak necessity modals like ‘ought’ and ‘should’. I start with the basic approach to the weak/strong necessity modal distinction developed in Silk 2018: Strong necessity modals are given their familiar semantics of necessity, predicating the necessity of the prejacent of the actual world (evaluation world). The apparent “weakness” of weak necessity modals derives from their bracketing the assumption that the relevant worlds in which the prejacent is necessary (deontically, epistemically, etc.) need be candidates (...) for actuality. ‘Should φ’ can be accepted without needing to settle that the relevant considerations (norms, preferences, expectations, etc.) that actually apply, given the facts, verify the necessity of φ. I formalize these ideas within an Update with Centering framework. The meaning of ‘Should φ’ is explained, fundamentally, in terms of how its use updates attention toward possibilities in which φ is necessary. The semantics is also extended to deontic conditionals. The proposed analyses capture various contrasting logical properties and discourse properties of ‘should’ and ‘must’ — e.g., in sensitivities to standing contextual assumptions, entailingness, and force — and provide an improved treatment of largely neglected data concerning information-sensitivity. (shrink)

An enduring puzzle for theorists of autonomy in the broadly Kantian tradition is how to theorize failures of practical reason. If norms of practical rationality are supposed to be constitutive of agency itself, how can failures to live up them nonetheless be understood as expressions of that agency? Hegelian diagnoses of these difficulties typically emphasize the dichotomies that structure Kantian theories of autonomy, between activity and passivity, reason and nature, norm and desire. They seek to flesh out an alternative that (...) preserves a recognisably post-Kantian notion of autonomy whilst understanding freedom as something that essentially comes in degrees, insisting that self-determination always involves elements of other-determination, and stressing how free subjectivity is inseparable from socio-historically and institutionally bounded character-formation. This article contributes to articulating a Hegelian corrective to Kantian theories of autonomy by beginning to explain the role of habit in Hegel's conception of agency. Building on recent work on Hegel's metaphysics of expression, it shows how he allows us to see conative responses to the world as integral to character development and thus as expressive of free agency, rather than as interruptions to the proper functioning of practical reason. On Hegel's account, the expressive behaviour of mature, reflective agents is grounded in a pre-intentional, affective dimension of subjectivity and presupposes processes of habituation, which he locates at the level of the human ‘soul’. Habit, far from being ‘lifeless, contingent and particular’, is the means by which agents come to make objective contents their own. Understanding the role of habit in Hegel's system is integral to allowing an alternative conceptualization of autonomy to come into view, one on which rational agents express themselves through their affective and emotional responses, rather than merely being a contingent site of those responses. (shrink)

: In this commentary on Sinhababu’s Humean Nature I will explore three lines of inquiry. The first asks about the explanatory power of the Desire-Belief Theory of Reasoning, by way of wondering about how desires and beliefs combine with one another. The second question continues along these lines, asking about the further conditions Sinhababu places on reasoning and whether a theory of reasoning can be normatively neutral. The third points out the need for more clarity in his account of intention (...) by contrasting it with practical reasoning. Keywords: Desire; Belief; Humean Psychology; Intention; Practical Reasoning Meccanica e psicologia del ragionamento pratico Riassunto: In questo commento su Humean Nature di Neil Sinhababu intendo esplorare tre linee di indagine. La prima si interroga sul potere esplicativo della Desire-Belief Theory of Reasoning, indagando come desideri e credenze si combinano reciprocamente. La seconda prosegue su questa strada, interrogando le ulteriori condizioni che Sinhababu pone sul ragionamento e chiedendomi se una teoria del ragionamento possa essere normativamente neutrale. La terza individua il bisogno di maggiore chiarezza nella sua descrizione dell’intenzione, mostrandone le differenze rispetto al ragionamento pratico. Parole chiave: Desiderio; Credenza; Psicologia humeana; Intenzione; Ragionamento pratico. (shrink)

Most of us have grown up with faces on television that look back at us, talk to us, even whenwe ignore them. They smile at us, and seem to address us personally. But they cannot seeor hear us, and we may or may not know who they are. Increasingly, in societies wherescreens are prevalent , our encounters with fellow humanbeings are mediated in ways such as this. Has the ubiquitous intervention of screens in ourlives thus made it harder to understand (...) and communicate directly with one another? Or,have screens extended our capacity to empathise and ‘socialise’, bringing us face-to-facewith people and points of view that we otherwise would never have encountered? In thisessay, I examine the idea that cinematic perception enables us to see the social world froma radically different perspective, and that an experience of this perspective may in itself beethical. I focus on the use of ‘direct address’, and discuss two documentaries by Errol Morriswhere the technique of direct address is used in ways that complicate ideas of mediationand empathy: Mr. Death: The Rise and Fall of Fred A. Leuchter, Jr. and The Fog of War:Eleven Lessons from the Life of Robert S. McNamara . I also draw on the philosophyof Emmanuel Levinas, particularly his work on ethics and the face, to analyse the effects ofMorris’s techniques. The essay highlights the importance of responsibility in human communication, and maintains that by reflecting on the viewing situation we are betterpositioned to empathise with Morris’s controversial subjects. (shrink)

Big data, artificial intelligence, and increasingly precise biometric techniques have given state and private organizations unprecedented scope and power for the surveillance and dataveillance of migrants. In many cases, these technologies have evolved faster than our legal, political, and ethical mechanisms. This paper, drawing on current discussions of justice and non-domination, proposes a non-domination-based ethics of digital surveillance and mobility, in which the legitimacy of these technologies depends on their avoidance of the arbitrary use of power. This allows us to (...) ethically assess new technologies and justify juridical, democratic, and administrative mechanisms. (shrink)

The paper gives an account of Rāmakaṇṭha’s (950–1000) contribution to the Buddhist–Brāhmaṇical debate about the existence or non-existence of a self, by demonstrating how he carves out middle ground between the two protagonists in that debate. First three points of divergence between the Brāhmaṇical (specifically Naiyāyika) and the Buddhist conceptions of subjectivity are identified. These take the form of Buddhist denials of, or re-explanations of (1) the self as the unitary essence of the individual, (2) the self as the substance (...) to which mental properties belong, (3) the self as the agent of both physical actions and cognitions. The difference of Rāmakaṇṭha’s position from both Nyāya and Buddhism is then elaborated. He posits a self, but not one that is an eternally unchanging substance, nor one that is anything other than consciousness. Hence his difference from Nyāya. He falls with Buddhism in holding that consciousness does not require anything other than itself to inhere in, but departs from Buddhism in holding that consciousness is not momentary but enduring. The guiding metaphor here is light, but light considered as a dynamic, qualitatively unchanging repetition of the action of illumination. (shrink)

Suffering exile is more than the knowing the reality of it. It requires embracing it with all the pain this embrace represents… Suffering exile is accepting the tragedy of rupture, which characteri...

Originally published in 1961. The essays in this volume focus on the awareness of science and art, evolution and Freudian psychology. Besides the chapter on Darwin and Freud, the author discusses criticism, the fantasy element in drama and popular literature, the history of the novel, the motivation of science and the function of erotic art.