Intermediate filaments (IFs) formed by vimentin are less understood than their cytoskeletal partners, microtubules and F‐actin, but the unique physical properties of IFs, especially their resistance to large deformations, initially suggest a mechanical function. Indeed, vimentin IFs help regulate cell mechanics and contractility, and in crowded 3D environments they protect the nucleus during cell migration. Recently, a multitude of studies, often using genetic or proteomic screenings show that vimentin has many non‐mechanical functions within and outside of cells. These include signaling (...) roles in wound healing, lipogenesis, sterol processing, and various functions related to extracellular and cell surface vimentin. Extracellular vimentin is implicated in marking circulating tumor cells, promoting neural repair, and mediating the invasion of host cells by viruses, including SARS‐CoV, or bacteria such as Listeria and Streptococcus. These findings underscore the fundamental role of vimentin in not only cell mechanics but also a range of physiological functions. Also see the video abstract here https://youtu.be/YPfoddqvz-g. (shrink)

Graphical AbstractIn article 2000078, Alison Patteson et al. review the various functions of filamentous and non-filamentous vimentin. While the mechanical and intracellular roles of vimentin – such as providing protection of the nucleus and elasticity to the cytoskeleton – are well documented, recent studies point towards additional, non-mechanical functions for vimentin. These functions include signaling roles in wound healing, lipogenesis and sterol processing as well as a role in pathogen infection.

Humans are capable of extracting recurring patterns from their environment via statistical learning (SL), an ability thought to play an important role in language learning and learning more generally. While much work has examined statistical learning in infants and adults, less work has looked at the developmental trajectory of SL during childhood to see whether it is fully developed in infancy or improves with age, like many other cognitive abilities. A recent study showed modality‐based differences in the effect of age (...) during childhood: While visual SL improved with age, auditory SL did not. This finding was taken as evidence for modality‐based differences in SL. However, since that study used auditory linguistic stimuli (syllables), the differential effect of age may have been driven by stimulus type (linguistic vs. non‐linguistic) rather than modality. Here, we ask whether age will affect performance similarly in the two modalities when non‐linguistic auditory stimuli are used (familiar sounds instead of syllables). We conduct a large‐scale study of children's performance on visual and non‐linguistic auditory SL during childhood (ages 5–12 years). The results show a similar effect of age in both modalities: Unlike previous findings, both visual and non‐linguistic auditory SL improved with age. These findings highlight the stimuli‐sensitive nature of SL and suggest that modality‐based differences may be stimuli‐dependent, and that age‐invariance may be limited to linguistic stimuli. (shrink)

Generative Artificial Intelligence (GenAI), such as ChatGPT, shows great promise and potential and is gradually being used in mental health care, but it also raises ethical concerns. These relate t...

Background: Ethical conflict is a barrier to decision-making process and is a problem derived from ethical responsibilities that nurses assume with care. Intensive care unit nurses are potentially exposed to this phenomenon. A deep study of the phenomenon can help prevent and treat it. Objectives: This study was aimed at determining the frequency, degree, level of exposure, and type of ethical conflict among nurses working in the intensive care units. Research design: This was a descriptive cross-sectional research. Participants and research (...) context: In total, 382 nurses working in the intensive care units in Iranian hospitals were selected using the random sampling method. Data were collected using the Ethical Conflict in Nursing Questionnaire-Critical Care Version (Persian version). Ethical considerations: This study was approved by the Medical Research Ethics Committee. Ethical considerations such as completing the informed consent form, ensuring confidentiality of information, and voluntary participation were observed. Findings: The results showed that the average level of exposure to ethical conflict was 164.39 ± 79.06. The most frequent conflict was related to “using resources despite believing in its futility,” with the frequency of at least once a week or a month (68.6%, n = 262). The most conflictive situation was violation of privacy (76.9%, n = 294). However, the level of exposure to ethical conflict according to the theoretical model followed was the situation of “working with incompetent staff.” The most frequently observed type of conflict was moral dilemma. Conclusion: The moderate level of exposure to ethical conflict was consistent with the results of previous studies. However, the frequency, degree, and type of ethical conflict were different compared to the results of other studies. Recognizing ethical conflict among intensive care unit nurses can be useful as it allows to consolidate those measures that favor low levels of ethical conflict, design appropriate strategies to prevent ethical conflicts, and improve the nursing work environment. (shrink)

Contributors to the recent disagreement debate have sought to provide a uniform response to cases in which epistemic peers disagree about the epistemic import of a shared body of evidence, no matter what kind of evidence they are disagreeing about. The varied cases addressed in the literature have included examples of disagreement about restaurant bills, court verdicts, weather forecasting, chess, morality, religious beliefs, and even disagreements about philosophical disagreements. The equal treatment of these varied cases has motivated the search for (...) a uniform response to peer disagreement wherever it is encountered. In this article I challenge this prevalent approach in the literature. I grant the notion of epistemic peer and accept that being a peer may amount to the same thing in different domains; nonetheless I contend that different domains appear to call for different responses to disagreement. I argue that the appropriate response to finding out about a disagreement with a peer is different in different domains. (shrink)

Rabbi Chaim Hirschensohn was a religious Zionist thinker and one of the founders of the “Mizrachi” movement. The present article aims to trace his approach towards work: did he see work as a need, an obligation imposed upon the human being to sustain his household, or did he, perhaps, associate work with a religious value as an integral part of the theology which he steered by? The conclusion is that R. Hirschensohn's approach towards work is both a must for a (...) livelihood and part of Jewish and national identity, to the point where Redemption itself depends upon it. Work is also part of religious Zionist theology, one of whose proponents and founders Chaim Hirschensohn was. (shrink)

Cells live in dynamic environments that necessitate perpetual adaptation. Since cells have limited resources to monitor external inputs, they are required to maximize the information content of perceived signals. This challenge is not unique to microscopic life: Animals use senses to perceive inputs and adequately respond. Research showed that sensory‐perception is actively shaped by learning and expectation allowing internal cognitive models to “fill in the blanks” in face of limited information. We propose that cells employ analogous strategies and use internal (...) models shaped through the long process of evolutionary adaptation. Given this perspective, we postulate that cells are prone to “misperceptions,” analogous to visual illusions, leading them to incorrectly decode patterns of inputs that lie outside of their evolutionary experience. Mapping cellular misperception can serve as a fundamental approach for dissecting regulatory networks and could be harnessed to modulate cell behavior, a potentially new avenue for therapy. (shrink)

Plagiarism has been on the rise amongst university students in recent decades. This study puts university teachers in the spotlight and investigates their role in raising students’ awareness about plagiarism. To that end, plagiarism policies in 207 Iranian university TEFL teachers’ syllabuses were analyzed. The researchers analyzed the syllabuses to find out if they contain a plagiarism policy, and if so, how the term is defined; whether they approach the issue of plagiarism directly; if they offer students any guidelines on (...) how to avoid plagiarism; and if the consequences of committing plagiarism are specified. The results indicated that the majority of the syllabuses (83.6%) lacked a plagiarism policy and those that did include a policy were often vague in their definition of the phenomenon. However, when there was a plagiarism policy in the syllabuses, the teachers tried to address the issue directly half of the time and offered students brief guidelines on how to avoid plagiaristic behavior, which was a small step in the right direction. It is recommended that other higher education institutions make it obligatory for their academic staff to include a plagiarism policy in their syllabuses if they wish to cultivate academic integrity in students. (shrink)

The existing research on Peshitta has mostly overlooked the translation techniques used in Peshitta Psalms. Prior studies have primarily focused on comparing Peshitta Psalms with the Masoretic Text (MT), the Septuagint and Targum, leaving a gap in the analysis of Peshitta Psalms within the context of Classical Syriac Poetry. This study will delve into how adeptly the Syriac translator employed poetic elements to construct strophic structures and poetic style within the Peshitta Psalm. This article presents an analysis of strophic structure, (...) word repetition, sound figures and versification in the Syriac translation of Psalm 29, comparing them with their Hebrew counterparts. In this study, the utilisation of the Biblia Hebraica Stuttgartensia (BHS) is employed for the MT, while the ‘Leiden edition’ is employed for the Peshitta. The findings from this analysis reveal that the Syriac rendition of Psalm 29 within the Peshitta incorporates numerous poetic elements. This suggests the translator’s familiarity with the strophic arrangement, word repetition, alliteration and various other poetic characteristics utilised by Hebrew scribes. The Peshitta translation of Psalm 29 closely resembles the MT Hebrew text, resulting in a balance of fidelity and aesthetic elegance. The Syriac rendition incorporates poetic elements like strophic arrangement, word repetition and alliteration but employs these features in a distinct manner. The Syriac text has a lower frequency of alliteration and word repetition but still possesses appealing poetic characteristics. The Syriac approach to verse composition closely resembles the Hebrew method, with some exceptions. Contribution: This study explores the Syriac translator’s use of poetic elements in Peshitta Psalms, revealing their familiarity with Hebrew techniques and the unique incorporation of elements. It provides insights into the evolution of Classical Syriac Poetry and contributes to our understanding of Biblical and Syriac poetry. (shrink)

This paper shows how we can plausibly extend the guise of the good thesis in a way that avoids intellectualist challenge, allows animals to be included, and is consistent with the possibility of performing action under the cognition of their badness. The paper also presents some independent arguments for the plausibility of this interpretation of the thesis. To this aim, a teleological conception of practical attitudes as well as a cognitivist account of arational desires is offered.

In recent years, firms have greatly increased the amount of resources allocated to activities classified as Corporate Social Responsibility (CSR). While an increase in CSR expenditure may be consistent with firm value maximization if it is a response to changes in stakeholders' preferences, we argue that a firm's insiders (managers and large blockholders) may seek to overinvest in CSR for their private benefit to the extent that doing so improves their reputations as good global citizens and has a "warm-glow" effect. (...) We test this hypothesis by investigating the relation between firms' CSR ratings and their ownership and capital structures. Employing a unique data set that categorizes the largest 3000 U. S. corporations as either socially responsible (SR) or socially irresponsible (SI), we find that on average, insiders' ownership and leverage are negatively related to the firm's social rating, while institutional ownership is uncorrelated with it. Assuming that higher CSR ratings is associated with higher CSR expenditure level, these results support our hypothesis that insiders induce firms to over-invest in CSR when they bear little of the cost of doing so. (shrink)

How should one write, what words should one select, what forms and structures and organization, if one is pursuing understanding? Sometimes this is taken to be trivial question. I shall claim that it is not.[T]here is nothing that so alters the material qualities of the voice as the presence of thought behind what is being said: the resonance of the diphthongs, the energy of the labials are profoundly affected—as is the diction.philosophy and literature are akin in rich and meaningful ways. (...) Like philosophy, novels make arguments and explicitly engage the range of philosophical questions; and like literature, essential elements of philosophy include... (shrink)

It is obvious that the use of these various terms does not result in a miscellany of ideas such as it occurs in many New Age theories. In perennialists’ writings we have come to realize that this is not an attempt to mix traditions together, but is instead an attempt to utilize existing terminology when it is appropriate. The paper has focused at studying the anthropology of perfection in perennial philosophy. It has addressed issues such as the nature of ‘self (...) and the states of self-realization’, selfessness and selfi shness’, ‘the categories of man’, ‘the process of exaltation’, ‘attributes’, ‘qualities’, ‘rights and obligations of the superior man in traditional worldview. In various places of the paper we have resorted to artworks belonging to various traditions and different times to communicate the ideas and worldviews. They show how essential the role of artists and the art they produce is in keeping alive the reverence for perfection and continuity of tradition through their inspired imagination. The superior qualities are not necessarily those of rulers and conquerors. They are rather to be found in mythical heroes, prophets of God and sages of various traditions; those who, in Ghazali’s words, “possess inner vision”. Such individuals hold attributes of perfection; their bodies die, yet their characters live beyond time and space inspiring generations after generations. After all, to be a superior being means starting a never-ending journey of becoming. (shrink)

The acquaintance principle (AP) and the view it expresses have recently been tied to a debate surrounding the possibility of aesthetic testimony, which, plainly put, deals with the question whether aesthetic knowledge can be acquired through testimony—typically aesthetic and non-aesthetic descriptions communicated from person to person. In this context a number of suggestions have been put forward opting for a restricted acceptance of AP. This paper is an attempt to restrict AP even more.

The Kripkean conception of natural kinds (kinds are defined by essences that are intrinsic to their members and that lie at the microphysical level) indirectly finds support in a certain conception of a law of nature, according to which generalizations must have unlimited scope and be exceptionless to count as laws of nature. On my view, the kinds that constitute the subject matter of special sciences such as biology may very well turn out to be natural despite the fact that (...) their essences fail to be microphysical or micro-based. On the causal conception of natural kinds I privilege, the naturalness of a kind is a function of the fact that it figures prominently in at least one causal law. However, there is a strong tendency prevailing among contemporary philosophers to assume that, in order to count as proper laws generalizations must be expectionless. Since most generalizations tracked down by the special sciences turn out not to fulfill these criteria, what this conception of a law implies is that most of the generalizations the special sciences trade in are not proper laws. It follows that, on this view, most if not all of the kinds the special sciences dealing with turn out not to constitute natural kinds, understood as kinds to which bona fide laws apply. In order to establish that the non-microstructurally defined kinds that fall within the domain of enquiry of the special sciences are eligible for the status of natural kind, I must therefore establish that generalizations needn’t have unlimited scope and be exceptionless to count as laws of nature. This is precisely what I seek to do in this paper. I begin by arguing that the question “what is a law of nature?” is most naturally interpreted as the question “what features must generalizations exhibit in order to ground scientific explanations?” and by offering reasons to believe that generalizations needn’t be exceptionless and have unlimited scope to play the crucial role laws have been thought to play in scientific explanation. Drawing on Sandra Mitchell [Mitchell, S. (2000). Philosophy of Science, 67, 242–265] and James Woodward’s [Woodward, J. (1997). Philosophy of science, 64 (proceedings), 524–541; Woodward, J. (2000). British Journal for the philosophy of science, 51(2), 197–254; Woodward, J. (2001). Philosophy of science, 68, 1–20] work, I subsequently develop an alternative account of the criteria generalizations must satisfy in order to count as laws of nature, which at least some of the generalizations of the special sciences turn out to fulfill. I thus give credence to the idea that at least some of the kinds that fall within the domain of the special sciences figure in laws of nature, and I thereby restore the possibility that some special science kinds deserve to be deemed natural. (shrink)

Ptolemy presents only one argument for the eccentricity in his models of the superior planets, while each one of them has two eccentricities: one for center of the uniform motion, the other for the center of the constant distance. To take into account the first eccentricity, he introduces the equant point, but he provides no argument for the eccentricity of the center of the deferent. Why is the second eccentricity different from the first one? The 13 th century astronomer Quṭb (...) al-Dīn al-Shīrāzī, a member of the famous school of Marāgha, who was interested in this problem, suggests the “retrograde arcs” as the empirical origin of the second eccentricity and develops an argument to justify this conjecture. Although his argument is not without difficulty, his suggestion is in line with the suggestions made by some historians of astronomy in recent decades. Résumé Ptolémée ne donne qu'un seul argument pour expliquer dans son système l'excentricité des planètes supérieures, alors que chacune d'elles a deux excentricités: l'une par rapport au centre du mouvement uniforme, l'autre par rapport au centre de la distance constante. Pour rendre compte de la première excentricité, il introduit le point équant, mais il ne donne en revanche aucun argument pour l'excentricité par rapport au centre du cercle déférent. Or, pourquoi la seconde excentricité est-elle différente de la première? Quṭb al-Dīn al-Shīrāzī, astronome du xiii e siècle membre de l'école de Marāgha, qui s'est intéressé à cette question, a fait l'hypothèse que les “arcs de rétrogradation” constituent l'origine empirique de cette seconde excentricité. Bien que l'argument sur lequel il appuie cette hypothèse ne soit pas exempt de difficultés, sa suggestion rejoint celles faites par des historiens de l'astronomie durant les dernières décennies. (shrink)

A culturally cultivated ignorance with regard to the care and presentation of tightly-curled hair pervades American society. This ignorance masquerades as a discourse of manageability, which supports institutional prohibitions of historically Black American hairstyles. In other words, rather than acknowledging our knowledge deficits, we attribute the medical and aesthetic consequences of our ignorance to the hair itself. The insidious implication is that the display of tightly curled hair is not a matter of taste but indicative of a lack of self-care. (...) I conclude that this trend is racially prejudicial and that laws and education are possible mechanisms of redress. (shrink)

There are two kinds of view in the literature concerning the relevance of intention to permissibility. While subjectivism assumes that an agent acts permissibly if he or she believes that the conduct is necessary for a moral purpose, for objectivism the de facto presence of an objective reason to justify one’s deeds is what matters. Recently, Scanlon and Hanser defend a moderate version of objectivism and subjectivism, respectively. Although I have a degree of sympathy toward both views, I will argue (...) that the truth lies somewhere in between. The view that I suggest in this paper hopefully occupies a space between subjectivism and objectivism and can accommodate the intuitions that neither of those views cannot account for. (shrink)

This paper suggests a critique of the zombie argument that bypasses the need to decide on the truth of its main premises, and specifically, avoids the need to enter the battlefield of whether conceivability entails metaphysical possibility. It is argued that if we accept, as the zombie argument’s supporters would urge us, the assumption that an ideal reasoner can conceive of a complete physical description of the world without conceiving of qualia, the general principle that conceivability entails metaphysical possibility, and (...) the general principle that for any s and t the metaphysical possibility of s & − t entails that s does not necessitate t, we have to conclude not that materialism is false but rather that either materialism or the “mental paint” (or “phenomenist”) conception of phenomenality is false. And further, given the initial advantages of materialism, the fact that proponents of the zombie argument are not allowed to rely on arguments against materialism in confronting this dilemma, and difficulties with arguments in favor of phenomenism, we find ourselves pushed to reject the mental paint conception rather than materialism. Or at any rate, it is hard to see how the proponent of the zombie argument can carry the burden of proof that lies with her. Thus, whether or not those premises of the zombie argument are true, the argument fails to refute materialism. (shrink)

Computable analysis provides ways of representing points in a topological space, and therefore of defining a notion of computable points of the space. In this article, we investigate when two topologies on the same space induce different sets of computable points. We first study a purely topological version of the problem, which is to understand when two topologies are not $\sigma $ -homeomorphic. We obtain a characterization leading to an effective version, and we prove that two topologies satisfying this condition (...) induce different sets of computable points. Along the way, we propose an effective version of the Baire category theorem which captures the construction technique, and enables one to build points satisfying properties that are co-meager with respect to a topology, and are computable with respect to another topology. Finally, we generalize the result to three topologies and give an application to prove that certain sets do not have computable type, which means that they have a homeomorphic copy that is semicomputable but not computable. (shrink)

In "Contents just are in the head" (Erkenntnis 54, pp. 321-4.) I have presented two arguments against the thesis of semantic externalism. In "Contents just aren't in the head" Anthony Brueckner has argued that my arguments are unsuccessful, since they rest upon some misconceptions regarding the nature of this thesis. (Erkenntnis 58, pp. 1-6.) In the present paper I will attempt to clarify and strengthen the case against semantic externalism, and show that Brueckner misses the point of my arguments.

This article aims to understand the concept of work in the teachings of Rabbi Avraham Yitzchak Hacohen Kook. As the person who had the maximum impact on the religious Zionist sector, with its guiding principle of Torah va’avodah, meaning Torah and work, it is necessary to clarify his attitude towards work. Did he perceive work as a necessity, a part of one’s duty to support the members of the household, or perhaps also as an ideological value, part of a worldview (...) that combines religious values with extra-religious values, or then again maybe he perceived work as a religious value? This article shows that R. Kook’s positive attitude towards work differs from traditional perspectives on work because of a pantheistic influence. Pantheism made him redefine the boundaries of Torah and include work and materiality. (shrink)

This book investigates the role of humor in the good life, specifically as discussed by three prominent French intellectuals who were influenced by Nietzsche's thought: Georges Bataille, Gilles Deleuze, and Clément Rosset. Lydia Amir begins by discussing Nietzsche's reception in France, and she explains why and how he came to be considered a "philosopher of laughter" in the French academe. Each of the subsequent three chapters focuses on the significance of humor and laughter in the good life as advocated (...) by Bataille, Deleuze, and Rosset. These chapters also explore the complex relationship between the comic and the tragic, and of humor and laughter to irony, satire, and ridicule. The Legacy of Nietzsche's Philosophy of Laughter makes an invaluable contribution to recent interpretive work done on Bataille and Deleuze, and offers further introduction to the relatively understudied Rosset. It illuminates the philosophies of these three thinkers, their connection to Nietzsche, and, overall, the significant role that humor plays in philosophy. (shrink)

Publication date: 31 January 2018 Source: Author: Amir Abbas Moslemi Ezra Pound’s Shi-Shu: Rats is read Foucauldianly to instantiate an interaction between Confucianism and Western schools of thought in response to the problem of evil. There is a review of Leibniz’s theodicy to clear up confusion, and also to pave the way for a succession of readings of a number of philosophers like Hume and James — foregrounding epistemic inclination of poets like Pope, Wordsworth and Burns. ‘Accidentality’ and ‘essentiality’ (...) are key philosophic terms, without which this problem cannot hold its logical structure, especially in terms of an answer. Epistemo-political ‘docility’ and literal ‘decency’ are employed together for the first time to be reintroducing ancient relationship between cruel politicians and carceral system. Utopia is taken as a mere dream so that ‘the problem’ would tend to keep its identity. What is new in this paper is a ‘gaze’-wise trace of mice in literature supporting the problem of evil in philosophy, based on an actual political background, within a broad sociological realm. (shrink)

Tel-Aviv University and York University, Toronto Plato suggested ways to regulate and integrate slaves within the legal system of his Utopian Cretan polis Magnesia as described in his work, Laws . This text alone invalidates most criticism of Popper's presentation of Plato's political views. His 50-year-old reading of Plato fits the text better than any other. To preserve the noble tradition of classical scholarship, classical scholars should acknowledge explicitly that he was correct, and that by now they have surreptitiously incorporated (...) the substance of his views. Key Words: Plato • slavery • apologetics • classical scholarship • Laws • Popper. (shrink)

The Companion will address the perennial topic of the human condition, which in the last twenty years has become the focus of attention again, first through related topics––such as the renewed interest in tragedy and the tragic sense of life, the problem of evil, the meaning in life, pessimism and joy––and also more directly, as testified by monographs addressing the human condition or the human predicament.

Like the navigation tools that freed ancient sailors from the need to stay close to the shoreline—eventually affording the discovery of new worlds—Big Data might open us up to new sociological possibilities by freeing us from the shackles of hypothesis testing. But for that to happen we need forensic social science: the careful compilation of evidence from unstructured digital traces as a means to generate new theories.

According to an idea which is widespread among philosophers, linguistic entities derive their intentionality from the intentionality of mental entities by virtue of some relation between them. Typically, it is some kind of intention on the speaker’s part – e.g., an intention to produce in the hearer a belief with a certain content – that is supposed to endow words with content. This paper argues that the concept of the derivation of content from one entity to another, if understood realistically, (...) is flawed: derived intentionality, I will argue, is merely ascribed intentionality, not a real property of its possessor. Irrealistic-ascriptivist senses are suggested for the ideas of content derivation, of original intentionality, and of the mind as the source of linguistic intentionality. Thus, endorsing the idea that mental intentionality is the source of non-mental intentionality need not tempt one to intentional realism. In an intentional irrealistic framework, what forms of intentionality are original and what are derived is a deeply contingent matter, determined by our practice of content ascription. But while intentional irrealism accommodates all those ideas, this paper defends “content-derivation irrealism” but not thoroughgoing intentional irrealism – the idea that there is real original intentionality is not ruled out. Still, assuming that some entities possess real intentionality, what can make them endow intentionality upon other entities is also our practice of content ascription. (shrink)

This Article analyzes the composition of the board of directors as a vehicle for state intervention in corporate governance. Such intervention is ubiquitous and often motivated by goals that stray from shareholder wealth maximization, or corporate governance more generally, to promote other national interests such as diversity. Regulating board composition thus is merely the continuation of politics by other means. After briefly discussing direct state ownership in business firms as a way to advance policy goals, the Article explicates the tensions (...) between boards’ dual responsibilities of monitoring and strategy-setting. These oftentimes conflicting missions curb the law’s ability to guide board members’ conduct through the conventional legal duties of loyalty and care or other injunctions. Although the two roles also may entail conflicting implications for board composition, regulation of board composition nonetheless may prove a superior means for promoting policy goals, especially with regard to the objective of the corporation. Composition regulation harnesses board members’ personal attributes — specifically, their values — to facilitate the attainment of these goals. Instead of telling board members what to do, the state may fare better by regulating who they are. (shrink)